CN106109639A - A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING - Google Patents
A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING Download PDFInfo
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- CN106109639A CN106109639A CN201610839471.0A CN201610839471A CN106109639A CN 106109639 A CN106109639 A CN 106109639A CN 201610839471 A CN201610839471 A CN 201610839471A CN 106109639 A CN106109639 A CN 106109639A
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- fructus rosae
- rosae laevigatae
- herba euphorbiae
- euphorbiae humifusae
- lijunjing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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Abstract
The present invention relates to a kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING, be made up of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10 20:1 5.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae are used in combination with specific part by weight, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING
Poultry compound medicine, infected, by colon bacillus, the disease that causes for treating poultry.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, florfenicol etc. are to prevent and treat commonly using of this type of disease
Western medicine, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but therapeutic effect and
Drug resistance situation is not taken a turn for the better, and goes from bad to worse on the contrary.
Through retrieval, do not inquire and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and Western medicine are combined for treating poultry by colon bacillus
Infect the relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicines containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING
Thing, its synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to LIJUNJING, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING
Poultry compound medicine, be made up of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is
1:10-20:1-5。
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae are with specific weight
Amount ratio is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Herba Euphorbiae Humifusae of the present invention, Fructus Rosae Laevigatae weight are dry weight.
One, Herba Euphorbiae Humifusae, the Fructus Rosae Laevigatae mensuration to the drug resistance elimination effect of Western medicine
1. assay method
According to the weight ratio of Western medicine and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae be 1:10:1,1:20:2,1:20:5,1:30:5,1:25:4,
1:40:5 prepares Western medicine and Herba Euphorbiae Humifusae, the admixing medical solutions of Fructus Rosae Laevigatae respectively；Choose the bacterial strain to Western medicine drug resistance as subjects,
Utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid MIC situation of change to Resistant strain；Set Radix seu Caulis Parthenocissi tricuspidatae simultaneously
Grass, Fructus Rosae Laevigatae, each Western medicine single dose are sun comparison, compare as the moon if being not added with any medicine.
Above-mentioned process was cultivated for 3 generations the most continuously.
2. result of the test
After cultivating for 3 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
Can be concluded that by upper table
1. when the weight ratio of amoxicillin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, amoxicillin
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 32 times, it is seen then that drug resistance colon bacillus is to A Moxi
The drug resistance of woods substantially reduces.And when the weight ratio of amoxicillin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5
Time, amoxicillin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
2. when the weight ratio of florfenicol and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, florfenicol
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 32 times, it is seen then that drug resistance colon bacillus is to fluorobenzene Buddhist nun
The drug resistance examined substantially reduces.And when the weight ratio of florfenicol and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5
Time, florfenicol to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
3. when the weight ratio of colistin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, colistin
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 64 times, it is seen then that drug resistance colon bacillus is to Bacillus adhaerens
The drug resistance of element substantially reduces.And when the weight ratio of colistin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5
Time, colistin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
4., when the weight ratio of amikacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:5,1:25:4, amikacin is big to drug resistance
The minimal inhibitory concentration of intestinal Escherichia all reduces more than 128 times, it is seen then that the drug resistance colon bacillus drug resistance to amikacin
Property substantially reduces.And when the weight ratio of amikacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:30:5 and 1:40:5
Time, amikacin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
5. when the weight ratio of sulfamonomethoxine sodium and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4,
Sulfamonomethoxine sodium all reduces more than 64 times to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance large intestine
The drug resistance of sulfamonomethoxine sodium is substantially reduced by Escherichia.And when sulfamonomethoxine sodium and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae
When the weight ratio of son is 1:10:1,1:30:5 and 1:40:5, the sulfamonomethoxine sodium minimum to drug resistance colon bacillus
Mlc, compared with sun comparison (pure Western medicine) being not added with Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, does not has significant change.
6., when the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:20:5, LIJUNJING is to resistance to
The minimal inhibitory concentration of medicine colon bacillus all reduces more than 4 times, it is seen then that the drug resistance colon bacillus drug resistance to LIJUNJING
Property substantially reduces.And when the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is and when 1:25:4,1:30:5,1:40:5, LIJUNJING
To the minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, do not have
Significant change.
7., when the weight ratio of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5, norfloxacin is big to drug resistance
The minimal inhibitory concentration of intestinal Escherichia all reduces more than 8 times, it is seen then that the drug resistance colon bacillus drug resistance to norfloxacin
Substantially reduce.And when the weight ratio of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5,1:25:4 and 1:40:5,
Norfloxacin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure Western medicine) phase
Ratio, does not has significant change.
8. the combination weight ratio working as ceftiofur sodium and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:20:5,1:25:
4, when 1:30:5,1:40:5, to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares
(pure Western medicine) is compared, and does not has significant change.
9., when the weight ratio of fosfomycin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:5, fosfomycin is to drug resistance large intestine angstrom
The minimal inhibitory concentration of uncommon Salmonella all reduces more than 16 times, it is seen then that drug resistance colon bacillus is obvious to the drug resistance of fosfomycin
Reduce.And when the weight ratio of fosfomycin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:25:4,1:30:5 and 1:40:5, fosfomycin
To the minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, do not have
Significant change.
Two, the experiment in vitro that Western medicine and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae are used in combination
By amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine sodium, LIJUNJING, promise fluorine sand
Star, 8 kinds of Western medicine of ceftiofur sodium are that 1:20:5 mixes with Herba Euphorbiae Humifusae (powder) and Fructus Rosae Laevigatae (powder) according to weight ratio respectively, make scattered
Agent, respectively as test group 1#-8#；Separately set amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine
Sodium, LIJUNJING, norfloxacin, ceftiofur sodium, Herba Euphorbiae Humifusae single dose, Fructus Rosae Laevigatae single dose, Herba Euphorbiae Humifusae+Fructus Rosae Laevigatae (20:5) make respectively
For matched group 1#-11#.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 19 groups of administrations.The equal SM of each group 5 days.
Dosage and result of the test are as shown in the table:
| Group | Dosage (g) | Situation after sick chicken medication 5 days |
| Test group 1# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 2# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 3# | 8 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 4# | 6 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 5# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 6# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 7# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 8# | 10 | Feed intake increased, and without dead, chicken group be almost recovered |
| Matched group 1# | 0.2 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 2# | 0.2 | Great majority still wan, has the sick chicken death of 5% |
| Matched group 3# | 0.4 | Great majority still wan, has the sick chicken death of 3% |
| Matched group 4# | 0.3 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 5# | 0.2 | Great majority still wan, has the sick chicken death of 6% |
| Matched group 6# | 0.2 | Great majority still wan, has the sick chicken death of 6% |
| Matched group 7# | 0.2 | Great majority still wan, has the sick chicken death of 8% |
| Matched group 8# | 0.5 | Great majority still wan, has the sick chicken death of 5% |
| Matched group 9# | 10 | Great majority still wan, has the sick chicken death of 12% |
| Matched group 10# | 10 | Great majority still wan, has the sick chicken death of 19% |
| Matched group 11# | 10 | Great majority still wan, has the sick chicken death of 13% |
Claims (2)
1. one kind contains Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and the poultry compound medicine of LIJUNJING, it is characterised in that by LIJUNJING and Radix seu Caulis Parthenocissi tricuspidatae
Grass, Fructus Rosae Laevigatae composition, the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10-20:1-5.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839471.0A CN106109639A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839471.0A CN106109639A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING |
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| Publication Number | Publication Date |
|---|---|
| CN106109639A true CN106109639A (en) | 2016-11-16 |
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| CN201610839471.0A Withdrawn CN106109639A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989727A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and mequindox containing compound medicine for livestock and poultry |
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2016
- 2016-09-21 CN CN201610839471.0A patent/CN106109639A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989727A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and mequindox containing compound medicine for livestock and poultry |
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