CN106236885A - A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin - Google Patents
A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin Download PDFInfo
- Publication number
- CN106236885A CN106236885A CN201610839491.8A CN201610839491A CN106236885A CN 106236885 A CN106236885 A CN 106236885A CN 201610839491 A CN201610839491 A CN 201610839491A CN 106236885 A CN106236885 A CN 106236885A
- Authority
- CN
- China
- Prior art keywords
- fructus rosae
- rosae laevigatae
- herba euphorbiae
- euphorbiae humifusae
- norfloxacin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 35
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 229960001180 norfloxacin Drugs 0.000 title claims abstract description 20
- 244000144977 poultry Species 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 title claims abstract description 14
- 244000025254 Cannabis sativa Species 0.000 claims description 2
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 description 36
- 241000193830 Bacillus <bacterium> Species 0.000 description 26
- 210000001072 colon Anatomy 0.000 description 25
- 241000287828 Gallus gallus Species 0.000 description 23
- 235000013330 chicken meat Nutrition 0.000 description 23
- 230000002401 inhibitory effect Effects 0.000 description 16
- 235000013594 poultry meat Nutrition 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 235000021050 feed intake Nutrition 0.000 description 8
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 7
- 229960004821 amikacin Drugs 0.000 description 7
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 7
- 229960003022 amoxicillin Drugs 0.000 description 7
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 7
- 229960003760 florfenicol Drugs 0.000 description 7
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 7
- IZJAOWYNDLDRKM-UHFFFAOYSA-N sodium;(4-aminophenyl)sulfonyl-(6-methoxypyrimidin-4-yl)azanide Chemical compound [Na+].C1=NC(OC)=CC([N-]S(=O)(=O)C=2C=CC(N)=CC=2)=N1 IZJAOWYNDLDRKM-UHFFFAOYSA-N 0.000 description 7
- 108010078777 Colistin Proteins 0.000 description 6
- 229960003346 colistin Drugs 0.000 description 6
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 6
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 6
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 6
- 229960000308 fosfomycin Drugs 0.000 description 5
- YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- RFLHUYUQCKHUKS-JUODUXDSSA-M Ceftiofur sodium Chemical compound [Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 RFLHUYUQCKHUKS-JUODUXDSSA-M 0.000 description 3
- 241000588722 Escherichia Species 0.000 description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- 229960004467 ceftiofur sodium Drugs 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 241000607142 Salmonella Species 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000008155 medical solution Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- -1 LIJUNJING Chemical compound 0.000 description 1
- 101100346764 Mus musculus Mtln gene Proteins 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin, be made up of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, the weight ratio of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2 5.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae are used in combination with specific part by weight, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of husky containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and promise fluorine
The poultry compound medicine of star, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, florfenicol etc. are to prevent and treat commonly using of this type of disease
Western medicine, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but therapeutic effect and
Drug resistance situation is not taken a turn for the better, and goes from bad to worse on the contrary.
Through retrieval, do not inquire and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and Western medicine are combined for treating poultry by colon bacillus
Infect the relevant report of the disease caused.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound recipe containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin
Medicine, its synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to norfloxacin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of husky containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and promise fluorine
The poultry compound medicine of star, is made up of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, norfloxacin and Herba Euphorbiae Humifusae, the weight of Fructus Rosae Laevigatae
Amount ratio is 1:20:2-5.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: proving through experimental study, norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae are with specifically
Part by weight is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Herba Euphorbiae Humifusae of the present invention, Fructus Rosae Laevigatae weight are dry weight.
One, Herba Euphorbiae Humifusae, the Fructus Rosae Laevigatae mensuration to the drug resistance elimination effect of Western medicine
1. assay method
According to the weight ratio of Western medicine and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae be 1:10:1,1:20:2,1:20:5,1:30:5,1:25:4,
1:40:5 prepares Western medicine and Herba Euphorbiae Humifusae, the admixing medical solutions of Fructus Rosae Laevigatae respectively；Choose the bacterial strain to Western medicine drug resistance as subjects,
Utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid MIC situation of change to Resistant strain；Set Radix seu Caulis Parthenocissi tricuspidatae simultaneously
Grass, Fructus Rosae Laevigatae, each Western medicine single dose are sun comparison, compare as the moon if being not added with any medicine.
Above-mentioned process was cultivated for 3 generations the most continuously.
2. result of the test
After cultivating for 3 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
Can be concluded that by upper table
1. when the weight ratio of amoxicillin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, amoxicillin
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 32 times, it is seen then that drug resistance colon bacillus is to A Moxi
The drug resistance of woods substantially reduces.And when the weight ratio of amoxicillin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5
Time, amoxicillin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
2. when the weight ratio of florfenicol and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, florfenicol
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 32 times, it is seen then that drug resistance colon bacillus is to fluorobenzene Buddhist nun
The drug resistance examined substantially reduces.And when the weight ratio of florfenicol and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5
Time, florfenicol to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
3. when the weight ratio of colistin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, colistin
The minimal inhibitory concentration of drug resistance colon bacillus is all reduced more than 64 times, it is seen then that drug resistance colon bacillus is to Bacillus adhaerens
The drug resistance of element substantially reduces.And when the weight ratio of colistin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5
Time, colistin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
4., when the weight ratio of amikacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:5,1:25:4, amikacin is big to drug resistance
The minimal inhibitory concentration of intestinal Escherichia all reduces more than 128 times, it is seen then that the drug resistance colon bacillus drug resistance to amikacin
Property substantially reduces.And when the weight ratio of amikacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:30:5 and 1:40:5
Time, amikacin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
5. when the weight ratio of sulfamonomethoxine sodium and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4,
Sulfamonomethoxine sodium all reduces more than 64 times to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance large intestine
The drug resistance of sulfamonomethoxine sodium is substantially reduced by Escherichia.And when sulfamonomethoxine sodium and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae
When the weight ratio of son is 1:10:1,1:30:5 and 1:40:5, the sulfamonomethoxine sodium minimum to drug resistance colon bacillus
Mlc, compared with sun comparison (pure Western medicine) being not added with Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, does not has significant change.
6., when the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:20:5, LIJUNJING is to resistance to
The minimal inhibitory concentration of medicine colon bacillus all reduces more than 4 times, it is seen then that the drug resistance colon bacillus drug resistance to LIJUNJING
Property substantially reduces.And when the weight ratio of LIJUNJING and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is and when 1:25:4,1:30:5,1:40:5, LIJUNJING
To the minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, do not have
Significant change.
7., when the weight ratio of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:20:5, norfloxacin is big to drug resistance
The minimal inhibitory concentration of intestinal Escherichia all reduces more than 8 times, it is seen then that the drug resistance colon bacillus drug resistance to norfloxacin
Substantially reduce.And when the weight ratio of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:30:5,1:25:4 and 1:40:5,
Norfloxacin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares (pure Western medicine) phase
Ratio, does not has significant change.
8. the combination weight ratio working as ceftiofur sodium and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:20:5,1:25:
4, when 1:30:5,1:40:5, to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Herba Euphorbiae Humifusae, the sun of Fructus Rosae Laevigatae compares
(pure Western medicine) is compared, and does not has significant change.
9., when the weight ratio of fosfomycin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:10:1,1:20:5, fosfomycin is to drug resistance large intestine angstrom
The minimal inhibitory concentration of uncommon Salmonella all reduces more than 16 times, it is seen then that drug resistance colon bacillus is obvious to the drug resistance of fosfomycin
Reduce.And when the weight ratio of fosfomycin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2,1:25:4,1:30:5 and 1:40:5, fosfomycin
To the minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae, do not have
Significant change.
Two, the experiment in vitro that Western medicine and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae are used in combination
By amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine sodium, LIJUNJING, promise fluorine sand
Star, 8 kinds of Western medicine of ceftiofur sodium are that 1:20:5 mixes with Herba Euphorbiae Humifusae (powder) and Fructus Rosae Laevigatae (powder) according to weight ratio respectively, make scattered
Agent, respectively as test group 1#-8#；Separately set amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine
Sodium, LIJUNJING, norfloxacin, ceftiofur sodium, Herba Euphorbiae Humifusae single dose, Fructus Rosae Laevigatae single dose, Herba Euphorbiae Humifusae+Fructus Rosae Laevigatae (20:5) make respectively
For matched group 1#-11#.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 19 groups of administrations.The equal SM of each group 5 days.
Dosage and result of the test are as shown in the table:
| Group | Dosage (g) | Situation after sick chicken medication 5 days |
| Test group 1# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 2# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 3# | 8 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 4# | 6 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 5# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 6# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 7# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 8# | 10 | Feed intake increased, and without dead, chicken group be almost recovered |
| Matched group 1# | 0.2 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 2# | 0.2 | Great majority still wan, has the sick chicken death of 5% |
| Matched group 3# | 0.4 | Great majority still wan, has the sick chicken death of 3% |
| Matched group 4# | 0.3 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 5# | 0.2 | Great majority still wan, has the sick chicken death of 6% |
| Matched group 6# | 0.2 | Great majority still wan, has the sick chicken death of 6% |
| Matched group 7# | 0.2 | Great majority still wan, has the sick chicken death of 8% |
| Matched group 8# | 0.5 | Great majority still wan, has the sick chicken death of 5% |
| Matched group 9# | 10 | Great majority still wan, has the sick chicken death of 12% |
| Matched group 10# | 10 | Great majority still wan, has the sick chicken death of 19% |
| Matched group 11# | 10 | Great majority still wan, has the sick chicken death of 13% |
Claims (2)
1. one kind contains Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and the poultry compound medicine of norfloxacin, it is characterised in that by norfloxacin and ground
Brocade grass, Fructus Rosae Laevigatae composition, the weight ratio of norfloxacin and Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae is 1:20:2-5.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839491.8A CN106236885A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839491.8A CN106236885A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106236885A true CN106236885A (en) | 2016-12-21 |
Family
ID=57599126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610839491.8A Withdrawn CN106236885A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106236885A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989730A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and fluoroquinolone antibacterial medicine containing compound medicine for livestock and poultry |
-
2016
- 2016-09-21 CN CN201610839491.8A patent/CN106236885A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989730A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and fluoroquinolone antibacterial medicine containing compound medicine for livestock and poultry |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106139121A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and colistin | |
| CN106236885A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and norfloxacin | |
| CN106236882A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and florfenicol | |
| CN106266053A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and amoxicillin | |
| CN106267154A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and colistin | |
| CN106266051A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and amikacin | |
| CN106266052A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and fosfomycin | |
| CN106109639A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae, Fructus Rosae Laevigatae and LIJUNJING | |
| CN106138318A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and amoxicillin | |
| CN106138320A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and norfloxacin | |
| CN106109638A (en) | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and LIJUNJING | |
| CN106109549A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and norfloxacin | |
| CN106176897A (en) | A kind of poultry compound medicine containing Herba Euphorbiae Humifusae and LIJUNJING | |
| CN106237311A (en) | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and colistin | |
| CN106266057A (en) | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and amoxicillin | |
| CN106266058A (en) | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and amikacin | |
| CN106309634A (en) | Composite medicine containing cinnamon, cherokee rose fruit and ceftiofur sodium for beasts and birds | |
| CN106309631A (en) | Livestock and poultry compound drug with Radix Glycyrrhizae, Fructus Rosae Laevigatae and norfloxacin | |
| CN106266054A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and LIJUNJING | |
| CN106138321A (en) | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and LIJUNJING | |
| CN106334011A (en) | Liquorice, fructus rosae laevigatae and florfenicol-containing compound medicine for livestock | |
| CN106266056A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amoxicillin | |
| CN106236883A (en) | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and sulfamonomethoxine sodium | |
| CN106266055A (en) | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and sulfamonomethoxine sodium | |
| CN106236884A (en) | A kind of poultry compound medicine containing Radix Glycyrrhizae, Fructus Rosae Laevigatae and ceftiofur sodium |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161221 |
|
| WW01 | Invention patent application withdrawn after publication |