CN106266060A - A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin - Google Patents
A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin Download PDFInfo
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- CN106266060A CN106266060A CN201610841111.4A CN201610841111A CN106266060A CN 106266060 A CN106266060 A CN 106266060A CN 201610841111 A CN201610841111 A CN 201610841111A CN 106266060 A CN106266060 A CN 106266060A
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- cortex cinnamomi
- fructus rosae
- rosae laevigatae
- amikacin
- drug resistance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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Abstract
The present invention relates to a kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin, be made up of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae, the weight ratio of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20 25:4 5.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae are used in combination with specific part by weight, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin
Poultry compound medicine, infected, by colon bacillus, the disease that causes for treating poultry.
Background technology
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, florfenicol etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire and Cortex Cinnamomi, Fructus Rosae Laevigatae and Western medicine are combined for treating poultry by colon bacillus sense
The relevant report of the disease that dye causes.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicines containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin
Thing, its synergism is obvious, it is possible to eliminate the colon bacillus drug resistance to amikacin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin
Poultry compound medicine, be made up of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae, the weight ratio of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is
1:20-25:4-5。
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae are with specific weight
Amount ratio is used in combination, and has synergism obvious, and curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Cortex Cinnamomi of the present invention, Fructus Rosae Laevigatae weight are dry weight.
One, Cortex Cinnamomi, the Fructus Rosae Laevigatae mensuration to the drug resistance elimination effect of Western medicine
1. assay method
According to the weight ratio of Western medicine and Cortex Cinnamomi, Fructus Rosae Laevigatae be 1:10:1,1:20:2,1:20:5,1:30:5,1:25:4,1:
40:5 prepares Western medicine and Cortex Cinnamomi, the admixing medical solutions of Fructus Rosae Laevigatae respectively；Choose the bacterial strain to Western medicine drug resistance as subjects, utilization
Plate dilution method carries out Secondary Culture, measures each process medicinal liquid MIC situation of change to Resistant strain；Set Cortex Cinnamomi, Fructus Rosae Laevigatae simultaneously
Western medicine single dose sub, each is sun comparison, compares as the moon if being not added with any medicine.
Above-mentioned process was cultivated for 3 generations the most continuously.
2. result of the test
After cultivating for 3 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC (μ g/mL) of uncommon Salmonella is as shown in table 1:
Can be concluded that by upper table
1. when the weight ratio of amoxicillin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:5,1:25:4,1:30:5, amoxicillin pair
The minimal inhibitory concentration of drug resistance colon bacillus all reduces more than 32 times, it is seen then that drug resistance colon bacillus is to amoxicillin
Drug resistance substantially reduce.And when the weight ratio of amoxicillin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:20:2 and 1:40:5,
Amoxicillin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Cortex Cinnamomi, the sun of Fructus Rosae Laevigatae compares (pure Western medicine) phase
Ratio, does not has significant change.
2. when the weight ratio of florfenicol and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:5,1:25:4,1:30:5, florfenicol pair
The minimal inhibitory concentration of drug resistance colon bacillus all reduces more than 64 times, it is seen then that drug resistance colon bacillus is to florfenicol
Drug resistance substantially reduce.And when the weight ratio of florfenicol and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:20:2 and 1:40:5,
Florfenicol to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Cortex Cinnamomi, the sun of Fructus Rosae Laevigatae compares (pure Western medicine) phase
Ratio, does not has significant change.
3. when the weight ratio of colistin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, colistin pair
The minimal inhibitory concentration of drug resistance colon bacillus all reduces more than 128 times, it is seen then that drug resistance colon bacillus is to colistin
Drug resistance substantially reduce.And when the weight ratio of colistin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:30:5 and 1:40:5,
Colistin to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Cortex Cinnamomi, the sun of Fructus Rosae Laevigatae compares (pure Western medicine) phase
Ratio, does not has significant change.
4., when the weight ratio of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:5,1:25:4, amikacin is to drug resistance large intestine
The minimal inhibitory concentration of Escherichia all reduces more than 128 times, it is seen then that the drug resistance colon bacillus drug resistance to amikacin
Substantially reduce.And when the weight ratio of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:20:2,1:30:5 and 1:40:5, Ah
Meter Ka Xing to the minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Cortex Cinnamomi, Fructus Rosae Laevigatae,
There is no significant change.
5. when the weight ratio of sulfamonomethoxine sodium and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:2,1:20:5,1:25:4, sulphur
Between amine, Sulfamonomethoxine sodium all reduces more than 128 times to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance large intestine angstrom
The drug resistance of sulfamonomethoxine sodium is substantially reduced by uncommon Salmonella.And when sulfamonomethoxine sodium and Cortex Cinnamomi, Fructus Rosae Laevigatae
When weight ratio is 1:10:1,1:30:5 and 1:40:5, sulfamonomethoxine sodium is antibacterial to the minimum of drug resistance colon bacillus
Concentration, compared with sun comparison (pure Western medicine) being not added with Cortex Cinnamomi, Fructus Rosae Laevigatae, does not has significant change.
6., when the weight ratio of LIJUNJING and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:20:5, drug resistance large intestine angstrom is wished by LIJUNJING
The minimal inhibitory concentration of Salmonella all reduces more than 32 times, it is seen then that the drug resistance of LIJUNJING is substantially dropped by drug resistance colon bacillus
Low.And when the weight ratio of LIJUNJING and Cortex Cinnamomi, Fructus Rosae Laevigatae is and when 1:25:4,1:20:2,1:30:5,1:40:5, LIJUNJING pair
The minimal inhibitory concentration of drug resistance colon bacillus is compared with sun comparison (pure Western medicine) being not added with Cortex Cinnamomi, Fructus Rosae Laevigatae, the most substantially
Change.
7., when the weight ratio of norfloxacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:2,1:20:5, norfloxacin is to drug resistance large intestine
The minimal inhibitory concentration of Escherichia all reduces more than 8 times, it is seen then that drug resistance colon bacillus is bright to the drug resistance of norfloxacin
Aobvious reduction.And when the weight ratio of norfloxacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:30:5,1:25:4 and 1:40:5, promise fluorine
The minimal inhibitory concentration of drug resistance colon bacillus compared with sun comparison (pure Western medicine) being not added with Cortex Cinnamomi, Fructus Rosae Laevigatae, is not had by Sha Xing
There is significant change.
8. when the weight ratio of ceftiofur sodium and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20:5,1:25:4 and 1:30:5, ceftiofur
Sodium all reduces more than 16 times to the minimal inhibitory concentration of drug resistance colon bacillus, it is seen then that drug resistance colon bacillus is to cephalo
The drug resistance of ceftiofur sodium substantially reduces.And when the weight ratio of ceftiofur sodium and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:10:1,1:20:2 and 1:
During 40:5, ceftiofur sodium to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Cortex Cinnamomi, the sun of Fructus Rosae Laevigatae compares (pure
Western medicine) compare, there is no significant change.
9. when the combination weight ratio of fosfomycin and Cortex Cinnamomi, Fructus Rosae Laevigatae be 1:10:1,1:20:2,1:20:5,1:25:4,1:
When 30:5,1:40:5, to the minimal inhibitory concentration of drug resistance colon bacillus be not added with Cortex Cinnamomi, the sun of Fructus Rosae Laevigatae compares (pure west
Medicine) compare, there is no significant change.
Two, the experiment in vitro that Western medicine and Cortex Cinnamomi, Fructus Rosae Laevigatae are used in combination
By amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine sodium, LIJUNJING, promise fluorine sand
Star, 8 kinds of Western medicine of ceftiofur sodium are that 1:20:5 mixes with Cortex Cinnamomi (powder) and Fructus Rosae Laevigatae (powder) according to weight ratio respectively, make scattered
Agent, respectively as test group 1#-8#；Separately set amoxicillin, florfenicol, colistin, amikacin, sulfamonomethoxine
Sodium, LIJUNJING, norfloxacin, ceftiofur sodium, Cortex Cinnamomi single dose, Fructus Rosae Laevigatae single dose, Cortex Cinnamomi+Fructus Rosae Laevigatae (20:5) are respectively as right
According to group 1#-11#.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 19 groups of administrations.The equal SM of each group 5 days.
Dosage and result of the test are as shown in the table:
| Group | Dosage (g) | Situation after sick chicken medication 5 days |
| Test group 1# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 2# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 3# | 8 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 4# | 6 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 5# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 6# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 7# | 4 | Feed intake increased, and without dead, chicken group be almost recovered |
| Test group 8# | 10 | Feed intake increased, and without dead, chicken group be almost recovered |
| Matched group 1# | 0.2 | Great majority still wan, has the sick chicken death of 3% |
| Matched group 2# | 0.2 | Great majority still wan, has the sick chicken death of 5% |
| Matched group 3# | 0.4 | Great majority still wan, has the sick chicken death of 2% |
| Matched group 4# | 0.3 | Great majority still wan, has the sick chicken death of 6% |
| Matched group 5# | 0.2 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 6# | 0.2 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 7# | 0.2 | Great majority still wan, has the sick chicken death of 1% |
| Matched group 8# | 0.5 | Great majority still wan, has the sick chicken death of 4% |
| Matched group 9# | 10 | Great majority still wan, has the sick chicken death of 13% |
| Matched group 10# | 10 | Great majority still wan, has the sick chicken death of 11% |
| Matched group 11# | 10 | Great majority still wan, has the sick chicken death of 10% |
Claims (2)
1. one kind contains Cortex Cinnamomi, Fructus Rosae Laevigatae and the poultry compound medicine of amikacin, it is characterised in that by amikacin and meat
Osmanthus, Fructus Rosae Laevigatae composition, the weight ratio of amikacin and Cortex Cinnamomi, Fructus Rosae Laevigatae is 1:20-25:4-5.
2. by the compound preparation become prepared by the poultry compound medicine described in claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610841111.4A CN106266060A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin |
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| CN201610841111.4A CN106266060A (en) | 2016-09-21 | 2016-09-21 | A kind of poultry compound medicine containing Cortex Cinnamomi, Fructus Rosae Laevigatae and amikacin |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989725A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and amikacin containing compound medicine for livestock and poultry |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989725A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and amikacin containing compound medicine for livestock and poultry |
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