CN106075329A

CN106075329A - A kind of Chinese medicine treating osteitis condensans ilium

Info

Publication number: CN106075329A
Application number: CN201610434853.5A
Authority: CN
Inventors: 陈帅; 高超; 于立芹
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-06-20
Filing date: 2016-06-20
Publication date: 2016-11-09

Abstract

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine treating osteitis condensans ilium and preparation method thereof.This Chinese medicine is made up of the raw material of Chinese medicine medicine of following weight portion: Semen Trigonellae 6 14 parts, Lignum Aquilariae Resinatum 37 parts, Fructus Foeniculi 6 14 parts, Radix Morindae Officinalis 6 14 parts, Cortex Eucommiae (parched) 6 14 parts, Semen Pharbitidis (parched) 15 parts, succinum 15 parts, Cortex Cinnamomi 15 parts, Fructus Evodiae 6 12 parts, Radix Ophiopogonis 6 12 parts, Radix Angelicae Sinensis 48 parts, Radix Paeoniae Rubra 48 parts, Rhizoma Chuanxiong 48 parts, Radix Ginseng 48 parts, Ramulus Cinnamomi 48 parts, 48 parts of Colla Corii Asini, Cortex Moutan 48 parts, 48 parts of Rhizoma Zingiberis Recens, 48 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 48 parts.This medicine has the sun of temperature compensation Liver and kidney, and cold expelling relieves the pain, channel warming and blood nourishing, effect of Huatan Zhuyu.For treating osteitis condensans ilium, there is cure rate and total effective rate is high, the advantage that untoward reaction is few.

Description

A kind of Chinese medicine treating osteitis condensans ilium

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine treating osteitis condensans ilium.

Background technology

Osteitis condensans ilium is bone density the increasing property disease betiding ilium ear articular portion.Main pathology changes Become ilium ear articular portion bone density to increase, mostly be unilateral, it is possible to bilateral is fallen ill.Its clinical manifestation and general waist sacrum disease Sick similar, easily obscure.It is reported, in the women of lumbosacral pain morbidity, recall rate reaches 18.82%.

Gestation, childbirth and wound are to cause the Etiological of osteitis condensans ilium, and this disease occurs in the woman given birth to more Female.First sacroiliac joint condensing osteitis is found in nineteen twenty-four by Braisford, adds up its sickness rate according to documents and materials and accounts for waist sacrum The 2.2% of portion's pathological changes.The cause of disease of primary disease is failed to understand so far, may think this in recent years with gestation, strain and Focal inflammation-related Disease is a kind of special ischemic necrosis.At latter half of gestation, and in birth process, due to the impact that endocrine is not normal, sacrum can be made The periarticular laxity of ligament of ilium, weakens the stability of sacroiliac joint；After whole body or half body anesthesia, it is possible to make around sacroiliac joint Laxity of ligament and cause primary disease.Mainly use nonsteroidal antiinflammatory drug symptomatic treatment, it is impossible to reach improvement office , there is the shortcoming that long-term taking side effect is big, curative effect is not good enough in the purpose of portion's blood supply.

It is, thus, sought for for the good effect treating osteitis condensans ilium, the medicine that untoward reaction is few.

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that Yi Zhongzhi Treating the Chinese medicine of osteitis condensans ilium, this medicine has the sun of temperature compensation Liver and kidney, and cold expelling relieves the pain, channel warming and blood nourishing, the merit of Huatan Zhuyu Effect.For treating osteitis condensans ilium, there is cure rate and total effective rate is high, the advantage that untoward reaction is few.

Another technical problem dosage form being to provide this Chinese medicine to be solved by this invention and preparation method thereof.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine treating osteitis condensans ilium, is made up of the raw material of Chinese medicine medicine of following weight portion:

Semen Trigonellae 6-14 part, Lignum Aquilariae Resinatum 3-7 part, Fructus Foeniculi 6-14 part, Radix Morindae Officinalis 6-14 part, Cortex Eucommiae (parched) 6-14 part, Semen Pharbitidis (parched) 1-5 Part, succinum 1-5 part, Cortex Cinnamomi 1-5 part, Fructus Evodiae 6-12 part, 6-12 part Radix Ophiopogonis, Radix Angelicae Sinensis 4-8 part, Radix Paeoniae Rubra 4-8 part, Rhizoma Chuanxiong 4-8 part, Radix Ginseng 4-8 part, Ramulus Cinnamomi 4-8 part, Colla Corii Asini 4-8 part, Cortex Moutan 4-8 part, Rhizoma Zingiberis Recens 4-8 part, Radix Glycyrrhizae 4-8 part, Rhizoma Pinelliae 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment osteitis condensans ilium, it is made up of the raw material of Chinese medicine medicine of following weight portion:

Semen Trigonellae 8-12 part, Lignum Aquilariae Resinatum 4-6 part, Fructus Foeniculi 8-12 part, Radix Morindae Officinalis 8-12 part, Cortex Eucommiae (parched) 8-12 part, Semen Pharbitidis (parched) 2-4 Part, succinum 2-4 part, Cortex Cinnamomi 2-4 part, Fructus Evodiae 8-10 part, 8-10 part Radix Ophiopogonis, Radix Angelicae Sinensis 5-7 part, Radix Paeoniae Rubra 5-7 part, Rhizoma Chuanxiong 5-7 part, Radix Ginseng 5-7 part, Ramulus Cinnamomi 5-7 part, Colla Corii Asini 5-7 part, Cortex Moutan 5-7 part, Rhizoma Zingiberis Recens 5-7 part, Radix Glycyrrhizae 5-7 part, Rhizoma Pinelliae 5-7 part.

It is furthermore preferred that the Chinese medicine of above-mentioned treatment osteitis condensans ilium, it is made up of the raw material of Chinese medicine medicine of following weight portion:

Semen Trigonellae 10 parts, Lignum Aquilariae Resinatum 5 parts, Fructus Foeniculi 10 parts, Radix Morindae Officinalis 10 parts, Cortex Eucommiae (parched) 10 parts, Semen Pharbitidis (parched) 3 parts, succinum 3 parts, Cortex Cinnamomi 3 parts, Fructus Evodiae 9 parts, Radix Ophiopogonis 9 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Chuanxiong 6 parts, Radix Ginseng 6 parts, Ramulus Cinnamomi 6 parts, 6 parts of Colla Corii Asini, male Cortex Moutan 6 parts, 6 parts of Rhizoma Zingiberis Recens, 6 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 6 parts.

The Chinese medicine of above-mentioned treatment osteitis condensans ilium, the dosage form of this Chinese medicine composition is oral formulations, permissible For decoction, tablet, pill, capsule, granule, the peroral dosage form that oral solution etc. is common.

The Chinese medicine of above-mentioned treatment osteitis condensans ilium, the preparation method of its decoction is: according to above-mentioned weight ratio Weighing medical material, (1) Lignum Aquilariae Resinatum, that Succinum powder is broken into fine powder is standby；Colla Corii Asini is pulverized standby；(2) in addition to Lignum Aquilariae Resinatum, succinum, Colla Corii Asini, other medicine Material adds the water of medical material volume 7-8 times together and decocts, and decocts 1-1.5 hour for the first time；Add medical material volume 5-6 times Water carries out second time and decocts, and second time decocts 1-1.5 hour, and collecting decoction is concentrated into 500-800ml.Divide and take for 2-3 time.Ah With medicinal liquid decoction liquor, Lignum Aquilariae Resinatum, succinum fine powder with clothes after glue molten.

Other peroral dosage forms can pharmaceutically may be used by independent after the extracting method extraction of pharmaceutical field routine or addition Oral formulations made by the adjuvant accepted,

Described pharmaceutically acceptable adjuvant is selected from: sucrose, starch, magnesium stearate, mannitol, sorbitol, sorbic acid or potassium Salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, dimension are raw Element C, vitamin E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or Its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, Fructus Vitis viniferae Sugar, fructose, dextran, glycine, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, Polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60～80, Span～80, Cera Flava, lanoline, liquid paraffin, 16 Alcohol, gallate ester, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, poly- Ethylene glycol, cyclodextrin, β～cyclodextrin, phospholipid material, Kaolin, Pulvis Talci, calcium stearate etc..

The Chinese medicine of the treatment osteitis condensans ilium of the present invention has the sun of temperature compensation Liver and kidney, and cold expelling relieves the pain, channel warming and blood nourishing, changes Effect of expectorant removing blood stasis, is clinically used for treating osteitis condensans ilium.

Osteitis condensans ilium belongs to " lumbago adds arthromyodynia " category, and its cause of disease is ferritic innate deficiency, or blood and essence asthenia, damages Cut down kidney qi." waist is house of kidney ", waist venation lose in warm, moisten foster, cause muscle impaired through, channels, obstruction of collaterals by blood stasis, and produce waist Bitterly." Plain Questions regulating menstruation opinion " is said: " cold solely staying then blood clotting tears, solidifying then arteries and veins is the most bitterly." " Jin Guiyi " say: " and expectorant blood lumbago person, sprain and contusion and Strongly weight lifting obtains it, the waist of lid waist person's ear, bends and stretches pitching, invariably by it.If one has damage, then blood vessels stagnate, and meridians are stopped up stagnant, order People's soldier's pain can not be changed one's position, and its hesitant pulse, day at light night is heavily also." errors in Medicine Corrected there is saying of " arthromyodynia having blood stasis ".Therefore ancients' treatment Lumbago is many starts with from temperature compensation Liver and kidney, cold relieving removing blood stasis pain relieving.

In the present invention, Semen Trigonellae, Fructus Foeniculi, Radix Morindae Officinalis, Cortex Eucommiae (parched), Cortex Cinnamomi enter kidney channel, power kidney-replenishing, the warm gate of vitality it Fire；Lignum Aquilariae Resinatum, Fructus Evodiae, Ramulus Cinnamomi dispelling cold by warming the meridian, promoting blood circulation, wherein Fructus Evodiae merit arrogates to oneself dispersing cold for relieving pain, and Ramulus Cinnamomi is longer than temperature promoting blood circulation, Lignum Aquilariae Resinatum enters spleen, stomach, kidney channel, helps Fructus Evodiae, Ramulus Cinnamomi cold expelling promoting the circulation of QI to relieve pain；It is monarch drug altogether.Radix Angelicae Sinensis, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, nourish blood tune Warp；Succinum dissipating blood stasis stops blooding；Cortex Moutan had both helped all medicine promoting blood circulation to remove blood stasis, and can purify the blood again a point deficiency-heat, was ministerial drug altogether.Colla Corii Asini is sweet flat, only nourishes blood Blood is nourshing Yin and drynsessmoistening prescription；The Radix Paeoniae Alba is bitter to be slightly cold, and nourish blood yin fluid astringing, easing the affected liver to relieve pain；Radix Ophiopogonis, sweetness and bitterness was slightly cold, replenishing YIN and removing heat.Three medicines share, and support Blood adjusts liver, nourshing Yin and drynsessmoistening prescription, and clearind deficient heat, and the warm-dryness syndrome of Fructus Evodiae (processed), Ramulus Cinnamomi.Radix Ginseng, Radix Glycyrrhizae replenishing QI to invigorate the spleen, as a means of biochemistry Source, Yin grows while yang is generating, the prosperous blood of gas fills；The Rhizoma Pinelliae, Rhizoma Zingiberis Recens are pungent opens eliminating stagnation, and logical fall gastric qi, to help promoting blood circulation by removing blood stasis；Wherein Rhizoma Zingiberis Recens stomach warming gas again To help biochemistry, and help Fructus Evodiae, Ramulus Cinnamomi with dispelling cold by warming the meridian；Semen Pharbitidis enters kidney and reduces phlegm, and lets out expectorant in kidney turbid；More than it is adjuvant drug.Sweet Grass still can coordinating the actions of various ingredients in a prescription, hold concurrently as making medicine.All medicines share, and play the sun of temperature compensation Liver and kidney altogether, and cold expelling relieves the pain, channel warming and blood nourishing, Huatan Zhuyu Effect, full side and reinforcing and reducing concurrently, lift the people having the same aspiration and interest, kept away, had benefit to have clearly so that QI and blood row, the expectorant stasis of blood is scattered, life-gate fire excess, Ensure patient nephroyin and nephroyang source without cease, make again blood vessels meridians unblocked, make extremity bones of the body collectively obtain vital essence nourish, warm, Reach the purpose for the treatment of.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about The present invention, but and it is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine treating osteitis condensans ilium, is made up of the raw material of Chinese medicine medicine of following weight:

Semen Trigonellae 10g, Lignum Aquilariae Resinatum 5g, Fructus Foeniculi 10g, Radix Morindae Officinalis 10g, Cortex Eucommiae (parched) 10g, Semen Pharbitidis (parched) 8g, Succinum powder 3g, Cortex Cinnamomi 3g, Fructus Evodiae 9g, 9g Radix Ophiopogonis, Radix Angelicae Sinensis 6g, Radix Paeoniae 6g, Rhizoma Chuanxiong 6g, Radix Ginseng 6g, Ramulus Cinnamomi 6g, Colla Corii Asini 6g, Cortex Moutan 6g, Rhizoma Zingiberis Recens 6g, Radix Glycyrrhizae 6g, Rhizoma Pinelliae 6g.

Embodiment 2

Semen Trigonellae 8 parts, Lignum Aquilariae Resinatum 4 parts, Fructus Foeniculi 12 parts, Radix Morindae Officinalis 8 parts, Cortex Eucommiae (parched) 12 parts, Semen Pharbitidis (parched) 4 parts, succinum 2 parts, meat 4 parts of osmanthus, Fructus Evodiae 8 parts, Radix Ophiopogonis 10 parts, Radix Angelicae Sinensis 5 parts, Radix Paeoniae Rubra 7 parts, Rhizoma Chuanxiong 5 parts, Radix Ginseng 7 parts, Ramulus Cinnamomi 5 parts, 7 parts of Colla Corii Asini, Paeonia suffruticosa Skin 5 parts, 7 parts of Rhizoma Zingiberis Recens, 5 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 7 parts.

Embodiment 3

Semen Trigonellae 12 parts, Lignum Aquilariae Resinatum 4 parts, Fructus Foeniculi 12 parts, Radix Morindae Officinalis 8 parts, Cortex Eucommiae (parched) 12 parts, Semen Pharbitidis (parched) 2 parts, succinum 4 parts, meat 2 parts of osmanthus, Fructus Evodiae 10 parts, Radix Ophiopogonis 8 parts, Radix Angelicae Sinensis 7 parts, Radix Paeoniae Rubra 5 parts, Rhizoma Chuanxiong 7 parts, Radix Ginseng 5 parts, Ramulus Cinnamomi 7 parts, 5 parts of Colla Corii Asini, Paeonia suffruticosa Skin 7 parts, 5 parts of Rhizoma Zingiberis Recens, 7 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 5 parts.

Embodiment 4

Semen Trigonellae 6 parts, Lignum Aquilariae Resinatum 7 parts, Fructus Foeniculi 14 parts, Radix Morindae Officinalis 6 parts, Cortex Eucommiae (parched) 4 parts, Semen Pharbitidis (parched) 1 part, succinum 1 part, Cortex Cinnamomi 5 parts, Fructus Evodiae 6 parts, Radix Ophiopogonis 12 parts, Radix Angelicae Sinensis 4 parts, Radix Paeoniae Rubra 8 parts, Rhizoma Chuanxiong 4 parts, Radix Ginseng 8 parts, Ramulus Cinnamomi 4 parts, 8 parts of Colla Corii Asini, Cortex Moutan 4 parts, 8 parts of Rhizoma Zingiberis Recens, 4 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 8 parts.

Embodiment 5

Semen Trigonellae 14 parts, Lignum Aquilariae Resinatum 3 parts, Fructus Foeniculi 14 parts, Radix Morindae Officinalis 6 parts, Cortex Eucommiae (parched) 14 parts, Semen Pharbitidis (parched) 1 part, succinum 5 parts, meat 1 part of osmanthus, Fructus Evodiae 12 parts, Radix Ophiopogonis 6 parts, Radix Angelicae Sinensis 8 parts, Radix Paeoniae Rubra 4 parts, Rhizoma Chuanxiong 8 parts, Radix Ginseng 4 parts, Ramulus Cinnamomi 8 parts, 4 parts of Colla Corii Asini, Paeonia suffruticosa Skin 8 parts, 4 parts of Rhizoma Zingiberis Recens, 8 parts of Radix Glycyrrhizae, the Rhizoma Pinelliae 4 parts.

The granule of the embodiment of the present invention 1 preparation has been carried out clinical trial, and Details as Follows:

1 clinical data

1 physical data chooses women osteitis condensans ilium patient 134 example, uses random digits table to be divided into treatment group and right According to organizing 2 groups: treatment group 82 example, year at age 22～40 (28.56 ± 5.52), multiparity 71 example, do not educate 11 examples, the course of disease is the shortest 6 days, Long 7 years.Matched group 52 example, year at age 20～42 (29.87 ± 5.03), multiparity, 44 examples, do not educate 8 examples, the course of disease is the shortest 5 days, the longest Nearly 8 years.Difference that 2 groups of physical data compare that there are no significant, has comparability.

2 Clinical symptoms young womens, multiparity person's onset are in the majority；Most of patients medical history 1～2 years, 1 example is 8 years；Starting disease Shape mostly is sacroiliac joint pain, then can have deadlock symptom in morning, the dyskinesia occurs；Lab testing HLA-B27 is negative；X-ray Triangle high density hardening zone seen from performance prompting sacroiliac joint ilium face, neat in edge, joint space is clear, and articular surface is smooth Sharp keen, pathological changes facies auricularis ossis ilii lower density increases uniformity, and without lucent area, bilateral morbidity is in the majority, and side performance is substantially；CT table Now prompting pathological changes involves sacroiliac joint ilium face, and pathological changes is fine and close, and uniformity, pathological changes inner edge is facies auricularis ossis ilii, and outer rim is the most whole Together, sacroiliac joint is smooth sharp keen, and joint space is without changing, and osteoporosis changes inconspicuous.

3 Therapeutic Method took celecoxib capsules (Pfizer, traditional Chinese medicines quasi-word J20120063), each 200mg, often Day 2 times.Continuous use 4 weeks.

Treatment group gives the Chinese medicine composition decoction of the embodiment of the present invention 1, weighs medical material according to above-mentioned weight ratio, (1) Lignum Aquilariae Resinatum, that Succinum powder is broken into fine powder is standby；Colla Corii Asini is pulverized standby；(2) in addition to Lignum Aquilariae Resinatum, succinum, Colla Corii Asini, other medical material is together The water adding medical material volume 7-8 times decocts, and decocts 1-1.5 hour for the first time；Add 5-6 times of water of medical material volume and carry out Secondary decocts, and second time decocts 1-1.5 hour, and collecting decoction is concentrated into 500-800ml.Divide and take for 2-3 time.After Colla Corii Asini molten With medicinal liquid decoction liquor, Lignum Aquilariae Resinatum, succinum fine powder with clothes.

4 observation index observe the impact of drugs on patients's pain degree, and pain degree uses NRS evaluation, with numeral 0-10 Represent pain in various degree, allow patient oneself iris out a numeral that can represent pain degree.0, painless；1-3, slightly aches Bitterly；4-6, moderate pain；7-10, severe pain.Record patient before treatment and after treatment 3,7,14,28d and drug withdrawal 2 weeks NRS marks, and detects patients' blood, heart rate, observes gastrointestinal reaction, anaphylaxis etc., serious adverse reaction once occurs, immediately Termination test, takes measure to the ill to treat.

" the Chinese medical disease Standardization of diagnosis and curative effect " that 5 efficacy assessment standards are promulgated according to State Administration of Traditional Chinese Medicine.Cure: Cardinal symptom disappears, and takes action, runs accessible, recovers normal work.Effective: pain disappears substantially, only do taskwork or long-time Work has discomfort, extensive recovery operation.Effective: pain relief more than half, slight obstacle of taking action, it is impossible to adapt to former work completely Make.Invalid: symptom, sign are not improved.

6 statistical methods use SPSS19.0 software to carry out statistical analysis.Measurement data, to represent, compares employing t between group Inspection, the measurement data not meeting normal distribution uses rank test；Enumeration data uses χ²Inspection.Inspection level be α= 0.05。

7 results

Matched group 1 example is not because Intolerance reaction exiting test, and remaining patient all obtains and follows up a case by regular visits to.

7.1 liang of group Clinical efficacy comparison treatment group total effective rates are better than matched group, and two groups are compared, and difference has statistics to anticipate Justice.It is shown in Table 1.

1 liang of table group Clinical efficacy comparison example

Group	n	Recovery from illness (example)	Effective (example)	Effectively (example)	Invalid (example)	Cure rate (%)	Total effective rate (%)
								Treatment group	82	39	20	11	2	47.56**	97.56**
Matched group	52	4	24	7	17	7.69	67.31

Note: compare with matched group, * * P ＜ 0.01

Before and after 7.2 liang of group treatments after each time period NRS scoring comparison therapy, two groups of pain degrees all have alleviation, and NRS marks fall Low.Treatment 3, the scoring of 7d treatment group NRS is higher than matched group, and two groups are compared, difference statistically significant (P < 0.05)；Treatment 14, 28d, two groups are compared, no significant difference (P > 0.05)；Treatment is followed up a case by regular visits to after terminating 2 weeks, and treatment group is less than matched group, difference Statistically significant (P < 0.05).It is shown in Table 2.

Before and after the group treatment of 2 liang of table, each time period NRS scoring is compared point

Group

n

Before treatment

Treatment 3d

Treatment 7d

Treatment 14d

Treatment 28d

Drug withdrawal 2 weeks

Treatment group

82

5.5±0.7

4.4±5.0

4.0±0.8

3.6±0.8

3.3±0.5

2.7±0.3

Matched group

52

5.6±1.3

3.9±1.1

3.5±1.0

3.4±0.9

3.3±0.4

3.8±0.6

T value

-0.242

3.569

3.035

1.249

0.775

-2.545

P value

0.853

0.001

0.005

0.203

0.521

0.012

7.3 untoward reaction treatment groups have no untoward reaction.There are the digestive system such as abdominal distention, dyspepsia, constipation in matched group 11 example Reaction, alleviates after anti symptom treatment, does not affect observation.

Claims

1. treat a Chinese medicine for osteitis condensans ilium, be made up of the raw material of Chinese medicine medicine of following weight portion:

The Chinese medicine for the treatment of osteitis condensans ilium the most according to claim 1, it is characterised in that by following weight portion Medicine crude drug forms:

The Chinese medicine for the treatment of osteitis condensans ilium the most according to claim 3, it is characterised in that by following weight portion Medicine crude drug forms:

4. according to the Chinese medicine of the treatment osteitis condensans ilium described in claim 1 or 2 or 3, it is characterised in that this Chinese medicine composition The dosage form of thing is oral formulations.