CN106075234A - 一种双辛鼻炎丸 - Google Patents

一种双辛鼻炎丸 Download PDF

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CN106075234A
CN106075234A CN201610637730.1A CN201610637730A CN106075234A CN 106075234 A CN106075234 A CN 106075234A CN 201610637730 A CN201610637730 A CN 201610637730A CN 106075234 A CN106075234 A CN 106075234A
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田丰
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Abstract

本发明涉及一种双辛鼻炎丸，它以辛夷10g、细辛3g、蝉衣10g、僵蚕10g、地龙10g、皂夹10g、苍耳子6g、黄芩10g、鹅不食草8g、白芷10g、薄荷10g、路路通10g、百部10g、生黄芪20g、炒白术15g、防风10g、紫芝6g、徐长卿15g为原料，经提辛夷和细辛的芳香精油与其它各药混均，制成丸剂。本发明能对鼻炎病发挥各药物综合调理的治疗作用，达到标本兼治，无毒副作用，且药效作用快，用药省，有良好的治愈效果。

Description

一种双辛鼻炎丸
技术领域
本发明涉及一种双辛鼻炎丸。
背景技术
鼻炎病是一种常见病，包括急、慢性鼻炎，鼻窦炎等多为顽固性疾病，常常数年不愈。患者临床表现为头痛脑胀，鼻塞脓涕，嗅觉和记忆减退，影响学习和工作。
西医不能解释其发病原理，常认为由细菌感染所致。西医采用对症治疗，如用麻黄素药收缩鼻血管，抗菌消炎的组胺类药物如西替利嗪，类固醇激素喷鼻等，这些西药不仅价格昂贵，而且大多为类固醇激素、抗菌性药物，疗效短，毒副作用高，而且多为内服，不能根治，且疗效也不能令人满意。
中医认为鼻炎病由风湿袭表或血虚生风以至气血失调而成。当前，治疗鼻炎病的中药较多，效果各异。但能充分发挥各药物综合调理的治疗作用，能达到标本兼治的中药较少。
发明内容
本发明的目的是提供一种双辛鼻炎丸，能对鼻炎病发挥各药物综合调理的治疗作用，达到标本兼治，无毒副作用，且药效作用快，用药省，有良好的治愈效果。
本发明是由下述重量配比的原料组分组成的：
本发明优选的各原料组分的重量配比是：
本发明最佳的各原料组分的重量配比是：
本发明的制备方法包括如下步骤：
(1)、把辛夷10g、细辛3g、白芷10g、薄荷10g和苍耳子6g，打粗粉过40目筛，放入400m L水装入烧瓶中，利用水蒸气蒸馏装置蒸馏3h，馏出液加入氯化钠至溶液饱和，再加入定量的乙醚摇匀，静置，去掉水层，用无水硫酸钠吸收水分后过滤，将滤液中乙醚回收，得到芳香精油；
(2)、将蝉衣10g、僵蚕10g和地龙10g，粉碎，过80目筛，置入压力罐内，杀菌，压力罐内压力103.4kPa，温度121℃，时间20min，处理得杀菌物，在杀菌物加入0.5mol/L乙酸溶液及胃蛋白酶，乙酸溶液600ml，胃蛋白酶质量0.15g，4℃溶胀12h，再匀浆搅拌36h，过滤，滤液9000r/min离心30min，得到酸性蛋白粗溶液；上清液中加入NaCl，至0.9mol/L，过夜离心收集沉淀物，将沉淀物溶于0.5mol/L乙酸溶液中；先用Na2HPO4透析2天，再用蒸馏水透析两天，冻干得酸性胶原蛋白；将胶原蛋白溶于水中，胶原蛋白与水用量比为30mg/ml，PH调至6.5，加入胶原蛋白酶0.1％的木瓜蛋白酶，水浴45℃反应4h，即酶解程度DH≤2.0，将反应液加热10min灭酶，过滤液冷冻干燥得胶原蛋白肽；
(3)、将皂夹10g、黄芩10g、鹅不食草8g、路路通10g、百部10g、生黄芪20g、炒白术15g、防风10g、紫芝6g和徐长卿15g，粉碎过200-300目筛，得细粉；
(4)、将步骤(1)至(3)得到的芳香精油、胶原蛋白肽和细粉混合均匀泛水为丸，每丸直径6mm；
(5)、采用Co60照射消毒法，对丸剂消毒后，分装。
所述的丸剂重量为3～3.5克。
本发明能对鼻炎病发挥各药物综合调理的治疗作用，达到标本兼治，无毒副作用，且药效作用快，用药省，有良好的治愈效果。
本发明中的中药：辛夷有祛风、通窍的功效。治头痛、鼻渊、鼻塞不通、齿痛。细辛别名辽细辛、北细辛、小辛，含拨发油，有辟秽、化浊、清暑、调经的作用。蝉衣别名蝉蜕，有散风热，宣肺和定痉的功效。僵蚕别名白僵蚕，有祛风解痉，化痰散结的功效。地龙别名蚯蚓，入肝、脾、肺经，清热，平肝，止喘，通络。皂夹、百部和苍耳子祛风痰，除湿毒，杀出，治头风头痛、咳嗽痰喘、鼻塞不通。黄芩泻实火，除湿热，治肺热咳嗽。白芷、防风和鹅不食草有祛风、散寒，胜湿，通鼻塞，治感冒，鼻渊、百日咳的功效。薄荷和路路通疏风，散热，辟秽，解毒。生黄芪别名黄耆，生黄芪益卫固表，利水消肿，托毒，生肌。炒白术补脾，益胃，燥湿，和中。紫芝《本经》称木芝，别名灵芝草，治虚劳，咳嗽，气喘，失眠，消化不良。徐长卿镇痛，止咳，利水消肿，活血解毒。
本发明上述各药相互作用，加之有效提取各药物的有效成份，能起到综合调理的治疗作用，达到标本兼治鼻炎病的目的，
本发明为丸剂，口服，每次1丸，每丸重3～3.5克，早晚各一次，15天为一个疗程，经临床150人次使用(年龄12～75岁)，诊断标准参照国家《实用耳鼻喉科学》《中医病症诊断疗效标准》本发明疗效如下：
1、治疗急性鼻炎，一个疗程有效率85～88％；二个疗程有效率87～90％。
2、治疗慢性鼻炎，一个疗程有效率75～80％；二个疗程有效率82～85％。
3、治疗急性鼻窦炎，一个疗程有效率82～84％；二个疗程有效率85～88％。
4、治疗慢性鼻窦炎，一个疗程有效率72～75％；二个疗程有效率77～80％。
典型病例：张某某、男、52岁，在医院确诊为急性鼻炎，该患者2014年9月用药前，头痛脑胀，鼻塞脓涕，嗅觉和记忆减退。服用本发明药2天，头痛脑胀止，鼻通气，服用四日后脓涕止，嗅觉和记忆恢复，饮食正常，继用15日，病灶区消失，无不适应，复查为痊愈。
华某某、女、25岁，在某中医院确诊为慢性鼻窦炎，头痛、鼻渊、鼻塞不通，服用本发明药7天，鼻通，疼痛即止，痊愈。
具体实施方式
实施例1：按下述配比称取原料：辛夷10g、细辛3g、蝉衣10g、僵蚕10g、地龙10g、皂夹10g、苍耳子6g、黄芩10g、鹅不食草8g、白芷10g、薄荷10g、路路通10g、百部10g、生黄芪20g、炒白术15g、防风10g、紫芝6g、徐长卿15g。
制备方法是：
(1)、把辛夷10g、细辛3g、白芷10g、薄荷10g和苍耳子6g，打粗粉过40目筛，放入400m L水装入烧瓶中，利用水蒸气蒸馏装置蒸馏3h。馏出液加入氯化钠至溶液饱和。再加入定量的乙醚摇匀，静置，去掉水层。用无水硫酸钠吸收水分后过滤。将滤液中乙醚回收，得到芳香精油。
(2)、将蝉衣10g、僵蚕10g和地龙10g，粉碎，过80目筛，置入压力罐内杀菌，压力罐内压力103.4kPa，温度121℃，时间20min，处理得杀菌物。在杀菌物加入0.5mol/L乙酸溶液及胃蛋白酶，乙酸溶液600ml，胃蛋白酶质量0.15g，4℃溶胀12h。再匀浆搅拌36h。过滤，滤液9000r/min离心30min，得到酸性蛋白粗溶液。上清液中加入NaCl，至0.9mol/L，过夜离心收集沉淀物。将沉淀物溶于0.5mol/L乙酸溶液中。先用Na2HPO4透析2天，再用蒸馏水透析两天，冻干得酸性胶原蛋白。将胶原蛋白溶于水中，胶原蛋白与水用量比为30mg/ml，PH调至6.5，加入胶原蛋白酶0.1％的木瓜蛋白酶，水浴45℃反应4h，即酶解程度DH≤2.0，将反应液加热10min灭酶，过滤液冷冻干燥得胶原蛋白肽。
(3)、将皂夹10g、黄芩10g、鹅不食草8g、路路通10g、百部10g、生黄芪20g、炒白术15g、防风10g、紫芝6g和徐长卿15g，粉碎过200-300目筛，得细粉。
(4)、将步骤(1)至(3)得到的芳香精油、胶原蛋白肽和细粉混合均匀泛水为丸，每丸直径6mm，约3克。
(5)、采用Co60照射消毒法(25KGY)，对丸剂消毒后，分装。
实施例2：按下述配比称取原料：辛夷12g、细辛5g、蝉衣8g、僵蚕12g、地龙8g、皂夹12g、苍耳子8g、黄芩12g、鹅不食草8g、白芷10g、薄荷10g、路路通12g、百部8g、生黄芪21g、炒白术13g、防风10g、紫芝6g、徐长卿15g。制备方法同上，加入的添加剂与实施例1等比。
总之，本发明能对鼻炎病发挥各药物综合调理的治疗作用，达到标本兼治，无毒副作用，且药效作用快，用药省，有良好的治愈效果。

Claims (5)

1.一种双辛鼻炎丸，其特征在于它是由下述重量配比的原料组分组成的：
2.根据权利要求1所述的一种双辛鼻炎丸，其特征在于其中各原料组分的重量配比是：
3.根据权利要求1所述的一种闻剂中草药，其特征在于其中各原料组分的重量配比是：
4.一种制备如权利要求1至3所述的一种双辛鼻炎丸的方法，其特征在于包括如下步骤：
(1)、把辛夷10g、细辛3g、白芷10g、薄荷10g和苍耳子6g，打粗粉过40目筛，放入400mL水装入烧瓶中，利用水蒸气蒸馏装置蒸馏3h，馏出液加入氯化钠至溶液饱和，再加入定量的乙醚摇匀，静置，去掉水层，用无水硫酸钠吸收水分后过滤，将滤液中乙醚回收，得到芳香精油；
(2)、将蝉衣10g、僵蚕10g和地龙10g，粉碎，过80目筛，置入压力罐内，杀菌，压力罐内压力103.4kPa，温度121℃，时间20min，处理得杀菌物，在杀菌物加入0.5mol/L乙酸溶液及胃蛋白酶，乙酸溶液600ml，胃蛋白酶质量0.15g，4℃溶胀12h，再匀浆搅拌36h，过滤，滤液9000r/min离心30min，得到酸性蛋白粗溶液；上清液中加入NaCl，至0.9mol/L，过夜离心收集沉淀物，将沉淀物溶于0.5mol/L乙酸溶液中；先用Na2HPO4透析2天，再用蒸馏水透析两天，冻干得酸性胶原蛋白；将胶原蛋白溶于水中，胶原蛋白与水用量比为30mg/ml，PH调至6.5，加入胶原蛋白酶0.1％的木瓜蛋白酶，水浴45℃反应4h，即酶解程度DH≤2.0，将反应液加热10min灭酶，过滤液冷冻干燥得胶原蛋白肽；
(3)、将皂夹10g、黄芩10g、鹅不食草8g、路路通10g、百部10g、生黄芪20g、炒白术15g、防风10g、紫芝6g和徐长卿15g，粉碎过200-300目筛，得细粉；
(4)、将步骤(1)至(3)得到的芳香精油、胶原蛋白肽和细粉混合均匀泛水为丸，每丸直径6mm；
(5)、采用Co60照射消毒法，对丸剂消毒后，分装。
5.根据权利要求4所述的方法，其特征在于：所述的丸剂重量为3～3.5克。
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