CN105816832A - 治疗风寒腰痛的中药凝胶膏帖及其制备方法 - Google Patents

治疗风寒腰痛的中药凝胶膏帖及其制备方法 Download PDF

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CN105816832A
CN105816832A CN201610211623.2A CN201610211623A CN105816832A CN 105816832 A CN105816832 A CN 105816832A CN 201610211623 A CN201610211623 A CN 201610211623A CN 105816832 A CN105816832 A CN 105816832A
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王华荣
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Abstract

本发明公开了一种治疗风寒腰痛的中药凝胶膏贴及其制备方法,所述中药凝胶膏帖包含以下重量份的组分:桂枝13‑18、炒杜仲8‑12、骨碎补13‑18、金毛狗脊8‑12、高良姜5‑8、茴香8‑11、川芎8‑12、牛膝8‑11、鸡血藤8‑12、巴戟天8‑11、补骨脂5‑8、萆薢8‑11、乌药2‑4、桑寄生8‑12、千年健8‑12、黄芪18‑25、萹蓄8‑12、桑枝8‑12、桃仁8‑12、干姜2‑5、艾叶30‑50、明胶20‑60、二氧化硅15‑40、聚丙烯酸钠10‑30、聚维酮10‑30、羧甲基纤维素钠6‑16、卡波姆2‑6、羟苯乙酯0.2‑1以及甘油100‑200。

Description

治疗风寒腰痛的中药凝胶膏帖及其制备方法
技术领域
[0001]本发明涉及中医药领域,尤其涉及一种治疗风寒腰痛的中药凝胶膏帖及其制备方法。
背景技术
[0002]腰痛为中医病症名,一般是指因外感、内伤或挫闪导致腰部气血运行不畅,或失于濡养,引起腰脊或脊旁部位疼痛为主要症状的一种病证。一般将腰痛归为风寒腰痛、寒湿腰痛、湿热腰痛、肾虚腰痛、瘀血腰痛等几类,按照虚实标本兼顾,对症下药。风寒腰痛为风邪伤于肾经所致腰痛,一般症状为:腰痛拘急,或连脊背,或引腰膝,或见寒热,腰间觉冷,得温痛减,脉浮而紧。对于风寒腰痛,治宜祛风、通络、活血,一般采用独活寄生汤、五积散、小续命汤等方治疗,但是治疗效果往往不理想。
[0003]西医中将腰肌纤维炎、强直性脊柱炎、腰椎骨质增生、腰椎间盘病变、腰肌劳损等以腰痛为主要症状者统称为腰痛。目前,西医中治疗腰痛一般采取消炎止痛等化学、抗生素药物,重症者采取手术的疗法,副作用大,恢复期长。
[0004]日常生活中,人们常用贴膏药的方法治疗或缓解腰痛,具有使用方便,药效可直接到达患处的优点,但是现有技术中的膏药对风寒腰痛的治疗效果往往不理想。
发明内容
[0005]本发明针对现有技术中存在的上述问题,提供一种治疗风寒腰痛的中药凝胶膏帖,治疗方便,针对风寒腰痛进行有效治疗,无副作用。
[0006]本发明还有一个目的是提供一种治疗腰痛的中药凝胶膏帖的制备方法,能够得到使用方便的,能够有效治疗风寒腰痛的凝胶膏帖。
[0007]为实现上述目的和一些其他的目的,本发明采用如下技术方案:
[0008] —种治疗风寒腰痛的中药凝胶膏贴,其中,包含以下重量份的组分:
[0009] 桂枝13-18、炒杜仲8-12、骨碎补13-18、金毛狗脊8-12、高良姜5-8、茴香8-11、川芎
8-12、牛膝8-11、鸡血藤8-12、巴戟天8-11、补骨脂5-8、萆蘚8-11、乌药2-4、桑寄生8-12、千年健8-12、黄芪18-25、篇蓄8-12、桑枝8-12、桃仁8-12、干姜2-5、艾叶30-50、明胶20-60、二氧化硅15-40、聚丙烯酸钠10-30、聚维酮10-30、羧甲基纤维素钠6-16、卡波姆2-6、羟苯乙酯0.2-1 以及甘油 100-200。
[0010]优选的是,所述的治疗风寒腰痛的中药凝胶膏帖中,包含以下重量份的组分:
[0011] 桂枝15、炒杜仲10、骨碎补15、金毛狗脊10、高良姜6、茴香9、川芎10、牛膝9、鸡血藤
10、巴戟天9、补骨脂6、萆蘚9、乌药3、桑寄生10、千年健10、黄芪20、篇蓄10、桑枝10、桃仁10、干姜3、艾叶40、明胶30、二氧化硅20、聚丙烯酸钠20、聚维酮20、羧甲基纤维素钠13、卡波姆
4、羟苯乙酯0.5以及甘油160。
[0012] —种治疗风寒腰痛的中药凝胶膏帖的制备方法,其中,包括以下步骤:
[0013]步骤一、将桂枝、炒杜仲、骨碎补、金毛狗脊、高良姜、茴香、川芎、牛膝、鸡血藤、巴戟天、补骨脂、萆蘚、乌药、桑寄生、千年健、黄芪、篇蓄、桑枝、桃仁、干姜以及艾叶干燥粉碎,研磨至120目以上,得到药粉,将所得药粉与20-30倍体积的质量浓度为50-80%的乙醇混合浸提,得到浸提液;
[0014]步骤二、将浸提液加热熬制成粘稠状,得到稠膏;
[0015]步骤三、将明胶加8-12倍水稀释,然后与稠膏及二氧化硅混合搅拌,得到混合药液;
[0016]步骤四、将聚丙烯酸钠、聚维酮、羧甲基纤维素钠、卡波姆、羟苯乙酯、甘油混合后与所得混合药液混合加热,得到中药膏;
[0017]步骤五、将所得中药膏涂布在棉布上,中药膏涂层厚度为2-3毫米,密封,即得所述中药凝胶膏帖。
[0018]本发明至少包括以下有益效果:首先,本发明利用中医五行及辨证理论,认为风寒腰痛为寒邪侵于腰肾,下焦寒冷,气血凝结,阻滞经络运行不通所致。本发明采用桂枝祛风寒湿邪,温经通络而缓解疼痛;炒杜仲温补肝肾、强筋骨;骨碎补补肾、活血;金毛狗脊补肝肾、强腰膝、祛风湿;高良姜祛寒湿;茴香温肾祛寒、止痛;川芎活血行气、祛风止痛;牛膝活血、补肝肾、强筋骨;鸡血藤行血补血、舒筋活络;巴戟天补肾助阳、祛风除湿;补骨脂补肾壮阳;萆蘚祛风湿、舒筋通络;乌药行气止痛、温肾散寒;桑寄生祛风湿、补肝肾、强筋骨;千年健祛风湿、健筋骨;黄芪益元气、壮脾胃;篇蓄利寒湿;桑枝祛风通络、利关节;桃仁活血祛瘀;干姜祛寒、温中;艾叶散寒止痛。本发明将以上多种中药合理配伍,温肾祛寒、活血通经,使风寒腰痛得以治愈。
[0019]其次,本发明通过把治疗风寒腰痛的中药组合物制备成中药凝胶膏帖的形式,可延长药物的作用时间长,使药物有效成分通过毛孔直接渗透入人体,方便使用。并且,中药凝胶膏帖相对于普通的膏药,用后容易去除,使用舒适性好,且不会污染衣物,使用更加方便。
[0020]根据临床统计,本发明所述中药凝胶膏帖对风寒腰痛的治愈率高,治愈率85%,总有效率达到97 %。
[0021]本发明的其它优点、目标和特征将部分通过下面的说明体现,部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
[0022]下面对本发明做详细说明,以令本领域普通技术人员参阅本说明书后能够据以实施。
[0023] —种治疗风寒腰痛的中药凝胶膏贴,其中,包含以下重量份的组分:桂枝13-18、炒杜仲8-12、骨碎补13-18、金毛狗脊8-12、高良姜5-8、茴香8-11、川芎8-12、牛膝8-11、鸡血藤8-12、巴戟天8-11、补骨脂5-8、萆蘚8-11、乌药2-4、桑寄生8-12、千年健8-12、黄芪18-25、篇蓄8-12、桑枝8-12、桃仁8-12、干姜2-5、艾叶30-50、明胶20-60、二氧化硅15-40、聚丙烯酸钠10-30、聚维酮10-30、羧甲基纤维素钠6-16、卡波姆2-6、羟苯乙酯0.2-1以及甘油100-200。
[0024]本发明利用中医五行及辨证理论,认为风寒腰痛为寒邪侵于腰肾,下焦寒冷,气血凝结,阻滞经络运行不通所致。本发明将多种中药合理配伍,温肾祛寒、活血通经,使风寒腰痛得以治愈。
[0025]本发明所述中药凝胶膏帖的具体药理为:
[0026]桂枝,祛风寒湿邪,温经通络而缓解疼痛;
[0027]炒杜仲,温补肝肾、强筋骨;
[0028] 骨碎补,补肾、活血;
[0029]金毛狗脊,补肝肾、强腰膝、祛风湿;
[0030]高良姜,祛寒湿;
[0031]茴香,温肾祛寒、止痛;
[0032 ]川;,活血行气、祛风止痛;
[0033]牛膝,活血、补肝肾、强筋骨;
[0034]鸡血藤,行血补血、舒筋活络;
[0035]巴戟天,补肾助阳、祛风除湿;
[0036]补骨脂,补肾壮阳;
[0037]萆蘚,祛风湿、舒筋通络;
[0038]乌药,行气止痛、温肾散寒;
[0039]桑寄生,祛风湿、补肝肾、强筋骨;
[0040]千年健,祛风湿、健筋骨;
[0041]黄芪,益元气、壮脾胃;
[0042] 篇蓄,利寒湿;
[0043]桑枝,祛风通络、利关节;
[0044]桃仁,活血祛瘀;
[0045]干姜,祛寒、温中;
[0046]本发明制备所述中药凝胶膏帖所用原料中所用艾叶较多,充分利用艾叶中散寒止痛的功效,将艾叶与其他组分的原料配合,制备为凝胶膏帖的形式,直接作用于腰部疼痛部位,使药效直达患处,充分吸收,提高治疗效果。
[0047]本发明所述治疗风寒腰痛的中药凝胶膏帖的制备方法主要包括以下步骤:步骤一、将桂枝、炒杜仲、骨碎补、金毛狗脊、高良姜、茴香、川芎、牛膝、鸡血藤、巴戟天、补骨脂、萆蘚、乌药、桑寄生、千年健、黄芪、篇蓄、桑枝、桃仁、干姜以及艾叶干燥粉碎,研磨至120目以上,得到药粉,将所得药粉与20-30倍体积的质量浓度为50-80%的乙醇混合浸提,得到浸提液;步骤二、将浸提液加热熬制成粘稠状,得到稠膏;步骤三、将明胶加8-12倍水稀释,然后与稠膏及二氧化硅混合搅拌,得到混合药液;步骤四、将聚丙烯酸钠、聚维酮、羧甲基纤维素钠、卡波姆、羟苯乙酯、甘油混合后与所得混合药液混合加热,得到中药膏;步骤五、将所得中药膏涂布在棉布上,中药膏涂层厚度为2-3毫米,密封,即得所述中药凝胶膏帖。
[0048]使用时,将所述中药凝胶膏帖直接贴于腰部疼痛部位,每贴保持20-24小时,每3-7天为一疗程,连续2-5个疗程。
[0049] 实施例1
[0050]步骤1、将以下重量份的原料干燥、粉碎、研磨:桂枝15、炒杜仲1、骨碎补15、金毛狗脊10、高良姜6、茴香9、川芎10、牛膝9、鸡血藤10、巴戟天9、补骨脂6、萆蘚9、乌药3、桑寄生10、千年健10、黄芪20、篇蓄10、桑枝10、桃仁10、干姜3以及艾叶40。
[0051]步骤2、将研磨得到的药粉与25倍体积的质量浓度为60%的乙醇混合浸提,得到浸提液,浸提温度为50-70摄氏度;
[0052]步骤3、浸提液加热熬制,得到稠膏;
[0053] 步骤4、将30重量份明胶加10倍水稀释,然后与稠膏及20重量份二氧化硅混合搅拌,得到混合药液;
[0054]步骤5、将聚丙烯酸钠20重量份、聚维酮20重量份、羧甲基纤维素钠13重量份、卡波姆4重量份、羟苯乙酯0.5重量份以及甘油160重量份混合,然后与所得混合药液混合加热,得到中药膏;
[0055]步骤6、将所得中药膏涂布在棉布上,中药膏涂层厚度为2-3毫米,密封,即得所述中药凝胶膏帖。
[0056]患者田某,女,54岁,患腰痛6个月,中医临床诊断为风寒腰痛,采用本实施例所述中药凝胶膏帖进行治疗,贴于腰部疼痛部位,每24小时更换一贴,每7贴为一疗程,I个疗程后症状明显减轻,三个疗程后疫愈。
[0057] 实施例2
[0058]步骤1、将以下重量份的原料干燥、粉碎、研磨:桂枝16、炒杜仲11、骨碎补16、金毛狗脊11、高良姜7、茴香10、川芎11、牛膝10、鸡血藤11、巴戟天11、补骨脂8、萆蘚8、乌药4、桑寄生11、千年健12、黄芪25、篇蓄12、桑枝12、桃仁8、干姜4以及艾叶45。
[0059]步骤2、将研磨得到的药粉与22倍体积的质量浓度为65%的乙醇混合浸提,得到浸提液,浸提温度为55摄氏度;
[0060]步骤3、浸提液加热熬制,得到稠膏;
[0061]步骤4、将40重量份明胶加12倍水稀释,然后与稠膏及25重量份二氧化硅混合搅拌,得到混合药液;
[0062]步骤5、将聚丙烯酸钠22重量份、聚维酮22重量份、羧甲基纤维素钠10重量份、卡波姆3重量份、羟苯乙酯0.8重量份以及甘油140重量份混合,然后与所得混合药液混合加热,得到中药膏;
[0063]步骤6、将所得中药膏涂布在棉布上,中药膏涂层厚度为2-3毫米,密封,即得所述中药凝胶膏帖。
[0064]患者王某,男,62岁,患腰痛3个月,中医临床诊断为风寒腰痛,采用本实施例所述中药凝胶膏帖进行治疗,贴于腰部疼痛部位,每24小时左右更换一贴,每5贴为一疗程,I个疗程后症状明显减轻,三个疗程后疫愈。
[0065]临床资料
[0066] 1、疗效评价标准:
[0067]治愈:腰痛症状消失。
[0068]显效:腰痛症状明显减轻。
[0069]有效:腰痛症状较治疗前减轻。
[0070]无效:病情无任何改善的表现。
[0071] 2、治疗方案:
[0072]将本发明所述中药凝胶膏帖贴于腰部疼痛部位,每24小时更换一贴,5-7贴为一个疗程,连续治疗2-5个疗程。
[0073] 3、治疗效果统计:
[0074]采用所述治疗方案对100例风寒腰痛患者进行治疗,并依据诊断标准进行统计。100例临床患者中,男性患者45例,女性患者55例,患者中年龄最小31岁,最大68岁,平均年龄43岁。经临床治疗,治愈85例,显效8例,有效4例,无效3例,总有效率97%,治愈率85%。
[0075]尽管本发明的实施方案已公开如上,但其并不仅仅限于说明书和实施方式中所列运用,它完全可以被适用于各种适合本发明的领域,对于熟悉本领域的人员而言,可容易地实现另外的修改,因此在不背离权利要求及等同范围所限定的一般概念下,本发明并不限于特定的细节。

Claims (3)

1.一种治疗风寒腰痛的中药凝胶膏贴,其特征在于,包含以下重量份的组分: 桂枝13-18、炒杜仲8-12、骨碎补13-18、金毛狗脊8-12、高良姜5-8、茴香8-11、川芎8-12、牛膝8-11、鸡血藤8-12、巴戟天8-11、补骨脂5-8、萆蘚8-11、乌药2-4、桑寄生8-12、千年健8-12、黄芪18-25、篇蓄8-12、桑枝8-12、桃仁8-12、干姜2-5、艾叶30-50、明胶20-60、二氧化硅15-40、聚丙烯酸钠10-30、聚维酮10-30、羧甲基纤维素钠6-16、卡波姆2-6、羟苯乙酯0.2-1 以及甘油 100-200。
2.如权利要求1所述的治疗风寒腰痛的中药凝胶膏帖,其特征在于,包含以下重量份的组分: 桂枝15、炒杜仲10、骨碎补15、金毛狗脊10、高良姜6、茴香9、川芎10、牛膝9、鸡血藤10、巴戟天9、补骨脂6、萆蘚9、乌药3、桑寄生10、千年健10、黄芪20、篇蓄10、桑枝10、桃仁10、干姜3、艾叶40、明胶30、二氧化硅20、聚丙烯酸钠20、聚维酮20、羧甲基纤维素钠13、卡波姆4、羟苯乙酯0.5以及甘油160。
3.—种如权利要求2所述的治疗风寒腰痛的中药凝胶膏帖的制备方法,其特征在于,包括以下步骤: 步骤一、将桂枝、炒杜仲、骨碎补、金毛狗脊、高良姜、茴香、川芎、牛膝、鸡血藤、巴戟天、补骨脂、萆蘚、乌药、桑寄生、千年健、黄芪、篇蓄、桑枝、桃仁、干姜以及艾叶干燥粉碎,研磨至120目以上,得到药粉,将所得药粉与20-30倍体积的质量浓度为50-80%的乙醇混合浸提,得到浸提液; 步骤二、将浸提液加热熬制成粘稠状,得到稠膏; 步骤三、将明胶加8-12倍水稀释,然后与稠膏及二氧化硅混合搅拌,得到混合药液; 步骤四、将聚丙烯酸钠、聚维酮、羧甲基纤维素钠、卡波姆、羟苯乙酯、甘油混合后与所得混合药液混合加热,得到中药膏; 步骤五、将所得中药膏涂布在棉布上,中药膏涂层厚度为2-3毫米,密封,即得所述中药凝胶膏帖。
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