CN106074368B - Pfkfb3抑制剂和用作抗癌治疗剂的方法 - Google Patents
Pfkfb3抑制剂和用作抗癌治疗剂的方法 Download PDFInfo
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- CN106074368B CN106074368B CN201610578370.2A CN201610578370A CN106074368B CN 106074368 B CN106074368 B CN 106074368B CN 201610578370 A CN201610578370 A CN 201610578370A CN 106074368 B CN106074368 B CN 106074368B
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
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- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US201261617073P | 2012-03-29 | 2012-03-29 | |
| US61/617,073 | 2012-03-29 | ||
| CN201380024610.9A CN104520274B (zh) | 2012-03-29 | 2013-03-14 | Pfkfb3抑制剂和用作抗癌治疗剂的方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380024610.9A Division CN104520274B (zh) | 2012-03-29 | 2013-03-14 | Pfkfb3抑制剂和用作抗癌治疗剂的方法 |
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| CN106074368A CN106074368A (zh) | 2016-11-09 |
| CN106074368B true CN106074368B (zh) | 2019-01-22 |
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| CN201380024610.9A Expired - Fee Related CN104520274B (zh) | 2012-03-29 | 2013-03-14 | Pfkfb3抑制剂和用作抗癌治疗剂的方法 |
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| US (2) | US9649305B2 (https=) |
| EP (1) | EP2831047B1 (https=) |
| JP (1) | JP6075903B2 (https=) |
| CN (2) | CN106074368B (https=) |
| AU (1) | AU2013240340B2 (https=) |
| CA (1) | CA2868787A1 (https=) |
| ES (1) | ES2629932T3 (https=) |
| IN (1) | IN2014DN08886A (https=) |
| WO (1) | WO2013148228A1 (https=) |
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| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| EP4245376A3 (en) | 2014-10-14 | 2023-12-13 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
| CA2979302A1 (en) * | 2015-05-13 | 2016-11-17 | Selvita S.A. | Substituted quinoxaline derivatives |
| WO2016191660A1 (en) * | 2015-05-28 | 2016-12-01 | University Of Louisville Research Foundation, Inc. | Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| EP3328418A1 (en) | 2015-07-29 | 2018-06-06 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
| HRP20211058T8 (hr) | 2015-07-29 | 2021-11-26 | Novartis Ag | Kombinirane terapije koje sadrže molekule antitijela protiv lag-3 |
| ES2986067T3 (es) | 2015-12-17 | 2024-11-08 | Novartis Ag | Moléculas de anticuerpos frente a PD-1 y usos de las mismas |
| AU2017357488A1 (en) * | 2016-11-08 | 2019-06-20 | Merck Patent Gmbh | Substituted quinoxaline derivatives as inhibitors of PFKFB |
| CN109136206B (zh) * | 2017-06-15 | 2021-07-23 | 厦门大学 | Pfkfb3蛋白的第194位酪氨酸的磷酸化及其应用 |
| CN109134434B (zh) * | 2017-11-06 | 2021-02-19 | 北京大学深圳研究生院 | 喹啉或喹唑啉类化合物及其制备方法和应用 |
| EP4010332A4 (en) * | 2019-08-06 | 2023-03-15 | The University of North Carolina at Chapel Hill | RNA TARGETED LIGANDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USE THEREOF |
| CN111228265A (zh) * | 2020-02-10 | 2020-06-05 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | p38γ抑制剂在制备治疗胰腺癌药物中的应用 |
| KR102344676B1 (ko) * | 2020-02-12 | 2021-12-30 | 한국과학기술연구원 | 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법 |
| CN111996247B (zh) * | 2020-08-27 | 2021-09-10 | 北京大学人民医院 | 糖酵解抑制剂及其在修复内皮细胞损伤中的应用 |
| CN114617884B (zh) * | 2020-12-10 | 2023-06-02 | 中国科学院大连化学物理研究所 | Pfk-158在制备抗冠状病毒药物中的应用及药物 |
| AU2022277294A1 (en) * | 2021-05-16 | 2023-12-07 | Metanoia Bio Inc. | Methods and compositions for treating pancreatic and hepatic disease |
| WO2023147161A2 (en) * | 2022-01-31 | 2023-08-03 | New Frontier Bio, Inc. | Nicotinate and nicotinamide riboside-based compounds and derivatives thereof |
| CN120695195A (zh) * | 2025-06-20 | 2025-09-26 | 华中科技大学同济医学院附属协和医院 | 靶向cdc20和糖酵解通路双靶点抑制剂在治疗子宫内膜癌中的应用 |
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| CN1182846C (zh) * | 2003-03-14 | 2005-01-05 | 南开大学 | 水溶性抗癌药紫杉醇复合物及其制备方法 |
| CN1554336A (zh) * | 2003-12-23 | 2004-12-15 | 广州国桥医药研究有限公司 | 水溶性青蒿素制剂的制备方法 |
| BRPI0509799A (pt) * | 2004-04-12 | 2007-11-13 | Torrent Pharmaceuticals Ltd | 2-propen-1-onas como indutores de hsp 70 |
| CN101020060A (zh) * | 2007-03-10 | 2007-08-22 | 杨喜鸿 | 恩替卡韦的环糊精包合物及其制备方法和药物应用 |
| AU2008266856A1 (en) * | 2007-06-18 | 2008-12-24 | University Of Louisville Research Foundation, Inc. | Family of PFKFB3 inhibitors with anti-neoplastic activities |
| EP2488533B1 (en) * | 2009-10-13 | 2014-07-23 | Council of Scientific & Industrial Research | Imidazothiazole-chalcone derivatives as potential anticancer agents and process for the preparation thereof |
| CN102000080A (zh) * | 2010-09-21 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种喜树碱类化合物的增溶方法 |
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- 2013-03-14 CA CA2868787A patent/CA2868787A1/en not_active Abandoned
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2017
- 2017-05-09 US US15/482,956 patent/US10010542B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN106074368A (zh) | 2016-11-09 |
| ES2629932T3 (es) | 2017-08-16 |
| CN104520274A (zh) | 2015-04-15 |
| AU2013240340A1 (en) | 2014-10-23 |
| EP2831047A1 (en) | 2015-02-04 |
| CA2868787A1 (en) | 2013-10-03 |
| US20170258783A1 (en) | 2017-09-14 |
| IN2014DN08886A (https=) | 2015-05-22 |
| WO2013148228A1 (en) | 2013-10-03 |
| US10010542B2 (en) | 2018-07-03 |
| AU2013240340B2 (en) | 2016-11-10 |
| JP6075903B2 (ja) | 2017-02-08 |
| JP2015512398A (ja) | 2015-04-27 |
| CN104520274B (zh) | 2016-08-24 |
| US20150064175A1 (en) | 2015-03-05 |
| US9649305B2 (en) | 2017-05-16 |
| EP2831047A4 (en) | 2015-09-02 |
| EP2831047B1 (en) | 2017-05-03 |
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