CN106063954A - A kind of medical apparatus and instruments implants blood pump - Google Patents
A kind of medical apparatus and instruments implants blood pump Download PDFInfo
- Publication number
- CN106063954A CN106063954A CN201610449844.3A CN201610449844A CN106063954A CN 106063954 A CN106063954 A CN 106063954A CN 201610449844 A CN201610449844 A CN 201610449844A CN 106063954 A CN106063954 A CN 106063954A
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- CN
- China
- Prior art keywords
- pump housing
- parts
- incubated
- hours
- ceramic material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008280 blood Substances 0.000 title claims abstract description 15
- 210000004369 blood Anatomy 0.000 title claims abstract description 15
- 239000007943 implant Substances 0.000 title description 2
- 229910010293 ceramic material Inorganic materials 0.000 claims abstract description 34
- MTPVUVINMAGMJL-UHFFFAOYSA-N trimethyl(1,1,2,2,2-pentafluoroethyl)silane Chemical class C[Si](C)(C)C(F)(F)C(F)(F)F MTPVUVINMAGMJL-UHFFFAOYSA-N 0.000 claims abstract description 20
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical class [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910001069 Ti alloy Inorganic materials 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 238000002161 passivation Methods 0.000 claims abstract description 8
- 238000005554 pickling Methods 0.000 claims abstract description 5
- 238000010438 heat treatment Methods 0.000 claims description 18
- 238000010792 warming Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 9
- 239000010936 titanium Substances 0.000 claims description 9
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 6
- -1 alkyl imidazoline quaternary ammonium salt Chemical class 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 229910052719 titanium Inorganic materials 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 3
- 239000004642 Polyimide Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000003723 Smelting Methods 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 3
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 claims description 3
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000956 alloy Substances 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 238000003763 carbonization Methods 0.000 claims description 3
- UFGZSIPAQKLCGR-UHFFFAOYSA-N chromium carbide Chemical compound [Cr]#C[Cr]C#[Cr] UFGZSIPAQKLCGR-UHFFFAOYSA-N 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- MQWFLKHKWJMCEN-UHFFFAOYSA-N n'-[3-[dimethoxy(methyl)silyl]propyl]ethane-1,2-diamine Chemical compound CO[Si](C)(OC)CCCNCCN MQWFLKHKWJMCEN-UHFFFAOYSA-N 0.000 claims description 3
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims description 3
- PQQKPALAQIIWST-UHFFFAOYSA-N oxomolybdenum Chemical compound [Mo]=O PQQKPALAQIIWST-UHFFFAOYSA-N 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 235000021110 pickles Nutrition 0.000 claims description 3
- 229920001721 polyimide Polymers 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- 229910052814 silicon oxide Inorganic materials 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 235000011149 sulphuric acid Nutrition 0.000 claims description 3
- 239000001117 sulphuric acid Substances 0.000 claims description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 3
- 229910003470 tongbaite Inorganic materials 0.000 claims description 3
- DQZNLOXENNXVAD-UHFFFAOYSA-N trimethoxy-[2-(7-oxabicyclo[4.1.0]heptan-4-yl)ethyl]silane Chemical compound C1C(CC[Si](OC)(OC)OC)CCC2OC21 DQZNLOXENNXVAD-UHFFFAOYSA-N 0.000 claims description 3
- 239000003643 water by type Substances 0.000 claims description 3
- 229910052726 zirconium Inorganic materials 0.000 claims description 3
- 229910001928 zirconium oxide Inorganic materials 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 3
- 238000004381 surface treatment Methods 0.000 abstract description 2
- 206010018910 Haemolysis Diseases 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 3
- 230000002785 anti-thrombosis Effects 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 1
- 210000004712 air sac Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008337 systemic blood flow Effects 0.000 description 1
- 150000003754 zirconium Chemical class 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C14/00—Alloys based on titanium
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- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/48—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on zirconium or hafnium oxides, zirconates, zircon or hafnates
- C04B35/481—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on zirconium or hafnium oxides, zirconates, zircon or hafnates containing silicon, e.g. zircon
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- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/515—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics
- C04B35/56—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbides or oxycarbides
- C04B35/5607—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbides or oxycarbides based on refractory metal carbides
- C04B35/5611—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbides or oxycarbides based on refractory metal carbides based on titanium carbides
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- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/62222—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products obtaining ceramic coatings
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- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
- C21D9/00—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor
- C21D9/0068—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor for particular articles not mentioned below
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- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/02—Making non-ferrous alloys by melting
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- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/16—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon
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- C22F1/183—High-melting or refractory metals or alloys based thereon of titanium or alloys based thereon
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- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
- C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
- C23C22/06—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6
- C23C22/34—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6 containing fluorides or complex fluorides
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- C23C24/00—Coating starting from inorganic powder
- C23C24/08—Coating starting from inorganic powder by application of heat or pressure and heat
- C23C24/082—Coating starting from inorganic powder by application of heat or pressure and heat without intermediate formation of a liquid in the layer
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- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C28/00—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
- C23C28/04—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material
- C23C28/042—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material including a refractory ceramic layer, e.g. refractory metal oxides, ZrO2, rare earth oxides
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- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G1/00—Cleaning or pickling metallic material with solutions or molten salts
- C23G1/02—Cleaning or pickling metallic material with solutions or molten salts with acid solutions
- C23G1/10—Other heavy metals
- C23G1/106—Other heavy metals refractory metals
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0211—Ceramics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
- C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
- C04B2235/30—Constituents and secondary phases not being of a fibrous nature
- C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
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- C04B2235/34—Non-metal oxides, non-metal mixed oxides, or salts thereof that form the non-metal oxides upon heating, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
- C04B2235/3418—Silicon oxide, silicic acids or oxide forming salts thereof, e.g. silica sol, fused silica, silica fume, cristobalite, quartz or flint
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Abstract
A kind of medical apparatus and instruments blood pump, blood pump includes that a pump housing, the pump housing pump housing include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide series ceramic material layer of pump housing inner surface, the composition of titanium alloy is simple;Titanium alloy to this composition carries out the surface treatment procedure of pickling and passivation, it is to avoid the problems such as any surface stain occurs, makes acquisition surface clean and tidy.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments blood pump, belongs to implantable pump, belongs to technical field of medical instruments.
Background technology
At present, apply extracorporeal circulation equipment to carry out heart surgery department and have become as the one for the treatment of heart disease
Conventional method.Cardiac insufficiency in various degree likely occurs after before surgery, needs the means such as heart-assist device to replace
For the pump function of heart, maintain systemic blood circulation, improve native heart function.Blood pump is the core group of ventricular assist device
Become part, provide power for ventricular assist device.Ventricular assist device blood pump many employings air sac pressing of at present commercialization or
, there is the complication such as aeroembolism, haemolysis in centrifugal driving principle.Existing pump housing material has been difficult to meet anti-hemolysis and antithrombotic etc. property
Can requirement.
Summary of the invention
A kind of technique that the present invention is aiming at the problems referred to above and proposes is simple, low cost, anti-hemolysis doctor of good performance
Treat apparatus blood pump.
A kind of medical apparatus and instruments blood pump, blood pump includes a pump housing, and the pump housing includes: the cast titanium alloy pump housing, pump housing outer surface
The titanium carbide series ceramic material layer of zirconium oxide series ceramic material layer and pump housing inner surface,
It is characterized in that, cast titanium alloy pump housing chemical composition is (weight): Zn:14.3, Al:6.2, Fe:4.4, Si:
1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.22, Zr:0.072, Ce:0.033, Mn:
0.051, V:0.062, B:0.084, surplus is Ti and inevitable impurity;
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters
Note: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C;After the demoulding, the pump housing obtained carries out heat treatment: first entered by the pump housing
Row heating, be warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100 DEG C/
Hour, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450 DEG C,
Rate of temperature fall 50 DEG C/h, is incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours, after
Air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO444 parts, the HCL of 36.5% 16 parts, propanoic acid 1.4 parts, ethylenediamine
1.3 parts, alkyl imidazoline quaternary ammonium salt 11 parts;12 parts of water;
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-
(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.3 parts, Sodium fluoroborate 11 parts, 1.5 parts of sulphuric acid, dialkyl group two
D2EHDTPA oxygen molybdenum 6.2 parts, 27 parts of water;
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material;Zirconium oxide is formed by being coated in pump housing outer surface
Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes (weight): oxygen
Change zirconium 52 parts, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.1 parts, the pump housing after coating is heated, is warming up to 750
DEG C, heating rate 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material;Titanium carbide system is formed by being coated in pump housing inner surface
Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes (weight): carbonization
Titanium 90 parts, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 6 parts, the pump housing after coating is heated, is warming up to 600 DEG C,
Heating rate 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again
Secondary it is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
Described pump housing inner surface is that blood passes through to touch the part on pump body surface when pump is internal, the pump housing remaining
Part is pump housing outer surface
Foregoing invention content having the beneficial effects that relative to prior art: 1) composition of titanium alloy is simple;2) to this composition
Titanium alloy carries out the surface treatment procedure of pickling and passivation, it is to avoid the problems such as any surface stain occurs, makes acquisition surface clean and tidy;
3) by the kind inner surface at the pump housing different with speed according to pump housing contact human body cell and outer surface titanium carbide
Series ceramic material and zirconium oxide series ceramic material layer, improve the performances such as the anti-hemolysis of material and antithrombotic.
Detailed description of the invention
In order to the technical characteristic of the present invention, purpose and effect are more clearly understood from, now describe the present invention's in detail
Detailed description of the invention.
Embodiment 1
A kind of medical apparatus and instruments blood pump, blood pump includes a pump housing, and the pump housing includes: the cast titanium alloy pump housing, the oxidation of pump housing outer surface
The titanium carbide series ceramic material layer of zirconium series ceramic material layer and pump housing inner surface,
It is characterized in that, cast titanium alloy pump housing chemical composition is (weight): Zn:14.3, Al:6.2, Fe:4.4, Si:
1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.22, Zr:0.072, Ce:0.033, Mn:
0.051, V:0.062, B:0.084, surplus is Ti and inevitable impurity;
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters
Note: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C;After the demoulding, the pump housing obtained carries out heat treatment: first entered by the pump housing
Row heating, be warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100 DEG C/
Hour, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450 DEG C,
Rate of temperature fall 50 DEG C/h, is incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours, after
Air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO444 parts, the HCL of 36.5% 16 parts, propanoic acid 1.4 parts, ethylenediamine
1.3 parts, alkyl imidazoline quaternary ammonium salt 11 parts;12 parts of water;
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-
(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.3 parts, Sodium fluoroborate 11 parts, 1.5 parts of sulphuric acid, dialkyl group two
D2EHDTPA oxygen molybdenum 6.2 parts, 27 parts of water;
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material;Zirconium oxide is formed by being coated in pump housing outer surface
Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes (weight): oxygen
Change zirconium 52 parts, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.1 parts, the pump housing after coating is heated, is warming up to 750
DEG C, heating rate 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material;Titanium carbide system is formed by being coated in pump housing inner surface
Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes (weight): carbonization
Titanium 90 parts, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 6 parts, the pump housing after coating is heated, is warming up to 600 DEG C,
Heating rate 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again
Secondary it is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
Claims (1)
1. a medical apparatus and instruments blood pump, blood pump include one (pump housing _, the pump housing pump housing includes: the cast titanium alloy pump housing, pump housing appearance
The zirconium oxide series ceramic material layer in face and the titanium carbide series ceramic material layer of pump housing inner surface,
It is characterized in that, cast titanium alloy pump housing chemical composition is (weight): Zn:14.3, Al:6.2, Fe:4.4, Si:
1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.22, Zr:0.072, Ce:0.033, Mn:
0.051, V:0.062, B:0.084, surplus is Ti and inevitable impurity;
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters
Note: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C;After the demoulding, the pump housing obtained carries out heat treatment: first entered by the pump housing
Row heating, be warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100 DEG C/
Hour, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450 DEG C,
Rate of temperature fall 50 DEG C/h, is incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours, after
Air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO444 parts, the HCL of 36.5% 16 parts, propanoic acid 1.4 parts, ethylenediamine 1.3
Part, alkyl imidazoline quaternary ammonium salt 11 parts;12 parts of water;
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-
(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.3 parts, Sodium fluoroborate 11 parts, 1.5 parts of sulphuric acid, dialkyl group two
D2EHDTPA oxygen molybdenum 6.2 parts, 27 parts of water;
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material;Zirconium oxide is formed by being coated in pump housing outer surface
Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes (weight): oxygen
Change zirconium 52 parts, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.1 parts, the pump housing after coating is heated, is warming up to 750
DEG C, heating rate 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material;Titanium carbide system is formed by being coated in pump housing inner surface
Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes (weight): carbonization
Titanium 90 parts, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 6 parts, the pump housing after coating is heated, is warming up to 600 DEG C,
Heating rate 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again
Secondary it is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
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US5477864A (en) * | 1989-12-21 | 1995-12-26 | Smith & Nephew Richards, Inc. | Cardiovascular guidewire of enhanced biocompatibility |
US6290640B1 (en) * | 1999-11-02 | 2001-09-18 | International Business Machines Corporation | Uncoupled rotary linear pump |
US8091556B2 (en) * | 2001-04-20 | 2012-01-10 | V-Wave Ltd. | Methods and apparatus for reducing localized circulatory system pressure |
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