CN104771797A - Blood pump in heart - Google Patents

Blood pump in heart Download PDF

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Publication number
CN104771797A
CN104771797A CN201510207488.XA CN201510207488A CN104771797A CN 104771797 A CN104771797 A CN 104771797A CN 201510207488 A CN201510207488 A CN 201510207488A CN 104771797 A CN104771797 A CN 104771797A
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parts
impeller
incubated
hours
ceramic material
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孙胜
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    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C14/00—Alloys based on titanium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/16—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon
    • C22F1/18—High-melting or refractory metals or alloys based thereon
    • C22F1/183—High-melting or refractory metals or alloys based thereon of titanium or alloys based thereon
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
    • C23C22/06—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6
    • C23C22/34—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6 containing fluorides or complex fluorides
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C28/00—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
    • C23C28/04—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material
    • C23C28/042—Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material including a refractory ceramic layer, e.g. refractory metal oxides, ZrO2, rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
    • C23G1/00—Cleaning or pickling metallic material with solutions or molten salts
    • C23G1/02—Cleaning or pickling metallic material with solutions or molten salts with acid solutions
    • C23G1/10—Other heavy metals
    • C23G1/106—Other heavy metals refractory metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C2222/00—Aspects relating to chemical surface treatment of metallic material by reaction of the surface with a reactive medium
    • C23C2222/20—Use of solutions containing silanes

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Ceramic Engineering (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)

Abstract

The invention discloses a blood pump in a heart. The blood pump comprises an impeller, wherein the impeller comprises a cast titanium alloy impeller body and an impeller body external zirconia system ceramic material layer, the blood pump is characterized in that the surface of the impeller is coated with an zirconia system ceramic material layer according to the difference of the kinds and the speeds of human cells which are in contact with the impeller, so that the compatibility of the materials and blood is improved.

Description

A kind of intracardiac blood pump
Technical field
The present invention relates to a kind of intracardiac blood pump, belongs to technical field of medical instruments.
Background technology
The statistics of World Health Organization (WHO) shows, heart failure disease and cardiogenic shock disease are day by day seriously threaten the health of the mankind.Therefore, if can artificial heart auxiliary device be developed, then can make very large contribution for the cause of healing the wounded and rescue the dying, social benefit and the prospect of marketing widely must be had.The countries such as U.S., day, Europe all develop rotary blood pump unexpectedly mutually.Use mechanical pump pumping blood, require that pump has biocompatibility, and in prior art, hemolysis is all not so good.This just requires that we manufacture impeller to meet the operation technique requirement of people's medical apparatus and instruments blood pump device.
Summary of the invention
The present invention is exactly that a kind of technique proposed for the problems referred to above is simple, cost is low, the intracardiac blood pump good with blood compatibility.
A kind of intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is Cu:12-13 ﹪, Al:9-10 ﹪, Si:5-6 ﹪, Zn:1-2 ﹪, Co:0.5-0.6 ﹪, Fe:0.2-0.3 ﹪, Ag:0.1-0.2 ﹪, Cr:0.1-0.2 ﹪, Zr:0.05-0.08 ﹪, La:0.05-0.08 ﹪, Ta:0.03-0.04 ﹪, B:0.02-0.03 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of: take 98% dense H 2sO 410-35 part, HCL 20-30 part of 36.5%, propanoic acid 1-3 part, ethylenediamine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part; Water 10-20 part;
Passivating solution consists of: polyimides 1-3 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 15-18 part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1-2 part, Sodium fluoroborate 10-13 part, sulphuric acid 1-4 part, dialkyl dithiophosphoric acid oxygen molybdenum 20-25 part, water 50-60 part;
Coating external oxidation zirconium series ceramic material is carried out to the impeller body after passivation, zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 70-90 part, titanium nitride 30-40 part, titanium carbide, 20-30 part, chromium oxide 10-15 part, impeller after coating is heated, be warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling is to room temperature, obtain final impeller.
Described a kind of intracardiac blood pump, cast titanium alloy impeller body chemical composition is Cu:12 ﹪, Al:9 ﹪, Si:5 ﹪, Zn:1 ﹪, Co:0.5 ﹪, Fe:0.2 ﹪, Ag:0.1 ﹪, Cr:0.1 ﹪, Zr:0.05 ﹪, La:0.05 ﹪, Ta:0.03 ﹪, B:0.02 ﹪, surplus is Ti and inevitable impurity.
Described a kind of intracardiac blood pump, cast titanium alloy impeller body chemical composition is Cu:13 ﹪, Al:10 ﹪, Si:6 ﹪, Zn:2 ﹪, Co:0.6 ﹪, Fe:0.3 ﹪, Ag:0.2 ﹪, Cr:0.2 ﹪, Zr:0.08 ﹪, La:0.08 ﹪, Ta:0.04 ﹪, B:0.03 ﹪, surplus is Ti and inevitable impurity.
Described a kind of intracardiac blood pump, cast titanium alloy impeller body chemical composition is Cu:12.5 ﹪, Al:9.5 ﹪, Si:5.5 ﹪, Zn:1.5 ﹪, Co:0.55 ﹪, Fe:0.25 ﹪, Ag:0.15 ﹪, Cr:0.15 ﹪, Zr:0.06 ﹪, La:0.06 ﹪, Ta:0.035 ﹪, B:0.025 ﹪, surplus is Ti and inevitable impurity.
Described a kind of intracardiac blood pump, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 70 parts, titanium nitride 30 parts, titanium carbide, 20 parts, chromium oxide 10 parts.
Described a kind of intracardiac blood pump, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 90 parts, titanium nitride 40 parts, titanium carbide 30 parts, chromium oxide 15 parts.
Described a kind of intracardiac blood pump, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 80 parts, titanium nitride 35 parts, titanium carbide, 25 parts, chromium oxide 13 parts.
Described a kind of intracardiac blood pump, pickle consists of: take 98% dense H 2sO 420 parts, the HCL of 36.5% 25 parts, propanoic acid 2 parts, ethylenediamine 3 parts, alkyl imidazoline quaternary ammonium salt 13 parts; 15 parts, water.
Described a kind of intracardiac blood pump, passivating solution consists of: polyimides 2 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 17 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1.5 parts, Sodium fluoroborate 12 parts, 3 parts, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 23 parts, 55 parts, water.
A kind of intracardiac blood pump preparation method, intracardiac blood pump comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is (quality): Cu:12-13 ﹪, Al:9-10 ﹪, Si:5-6 ﹪, Zn:1-2 ﹪, Co:0.5-0.6 ﹪, Fe:0.2-0.3 ﹪, Ag:0.1-0.2 ﹪, Cr:0.1-0.2 ﹪, Zr:0.05-0.08 ﹪, La:0.05-0.08 ﹪, Ta:0.03-0.04 ﹪, B:0.02-0.03 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of (quality): take 98% dense H 2sO 410-35 part, HCL 20-30 part of 36.5%, propanoic acid 1-3 part, ethylenediamine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part; Water 10-20 part;
Passivating solution consists of (quality): polyimides 1-3 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 15-18 part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1-2 part, Sodium fluoroborate 10-13 part, sulphuric acid 1-4 part, dialkyl dithiophosphoric acid oxygen molybdenum 20-25 part, water 50-60 part;
Coating external oxidation zirconium series ceramic material is carried out to the impeller body after passivation, zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises (quality): zirconium oxide 70-90 part, titanium nitride 30-40 part, titanium carbide, 20-30 part, chromium oxide 10-15 part, impeller after coating is heated, be warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling is to room temperature, obtain final impeller.
Foregoing invention content is relative to the beneficial effect of prior art: 1) composition of titanium alloy is simple; Intensity is higher; 2) titanium alloy of this composition is carried out to the surface treatment procedure of pickling and passivation, avoid occurring the problems such as any surperficial stain, make acquisition surface clean and tidy; 3) by the surface-coated zirconium oxide series ceramic material layer of the impeller that do not coexist in the kind and speed that contact human body cell according to impeller, material and blood compatibility is improved.
Detailed description of the invention
In order to there be understanding clearly to technical characteristic of the present invention, object and effect, now describe the specific embodiment of the present invention in detail.
Embodiment 1
A kind of intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is Cu:12 ﹪, Al:9 ﹪, Si:5 ﹪, Zn:1 ﹪, Co:0.5 ﹪, Fe:0.2 ﹪, Ag:0.1 ﹪, Cr:0.1 ﹪, Zr:0.05 ﹪, La:0.05 ﹪, Ta:0.03 ﹪, B:0.02 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1810 DEG C, pouring temperature is 1750 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of: take 98% dense H 2sO 410 parts, the HCL of 36.5% 20 parts, propanoic acid 1 part, ethylenediamine 1 part, alkyl imidazoline quaternary ammonium salt 10 parts; 10 parts, water;
Passivating solution consists of: polyimides 1 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 15 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1 part, Sodium fluoroborate 10 parts, 1 part, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 20 parts, 50 parts, water;
Coating external oxidation zirconium series ceramic material layer is carried out to the impeller body after passivation; Zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 70 parts, titanium nitride 30 parts, titanium carbide, 20 parts, chromium oxide 10 parts, heats the impeller after coating, is warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 2
A kind of intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is Cu:13 ﹪, Al:10 ﹪, Si:6 ﹪, Zn:2 ﹪, Co:0.6 ﹪, Fe:0.3 ﹪, Ag:0.2 ﹪, Cr:0.2 ﹪, Zr:0.08 ﹪, La:0.08 ﹪, Ta:0.04 ﹪, B:0.03 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1820 DEG C, pouring temperature is 1760 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of: take 98% dense H 2sO 435 parts, the HCL of 36.5% 30 parts, propanoic acid 3 parts, ethylenediamine 5 parts, alkyl imidazoline quaternary ammonium salt 15 parts; 20 parts, water;
Passivating solution consists of: polyimides 3 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 18 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2 parts, Sodium fluoroborate 13 parts, 4 parts, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 25 parts, 60 parts, water;
Coating external oxidation zirconium series ceramic material layer is carried out to the impeller body after passivation; Zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 90 parts, titanium nitride 40 parts, titanium carbide 30 parts, chromium oxide 15 parts, impeller after coating is heated, be warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, is incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 3
A kind of intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is Cu:12.5 ﹪, Al:9.5 ﹪, Si:5.5 ﹪, Zn:1.5 ﹪, Co:0.55 ﹪, Fe:0.25 ﹪, Ag:0.15 ﹪, Cr:0.15 ﹪, Zr:0.06 ﹪, La:0.07 ﹪, Ta:0.035 ﹪, B:0.025 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1815 DEG C, pouring temperature is 1755 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of: take 98% dense H 2sO 420 parts, the HCL of 36.5% 25 parts, propanoic acid 2 parts, ethylenediamine 3 parts, alkyl imidazoline quaternary ammonium salt 13 parts; 15 parts, water;
Passivating solution consists of: polyimides 2 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 16 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1.5 parts, Sodium fluoroborate 12 parts, 3 parts, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 23 parts, 55 parts, water;
Coating external oxidation zirconium series ceramic material layer is carried out to the impeller body after passivation; Zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 80 parts, titanium nitride 35 parts, titanium carbide 25 parts, chromium oxide 13 parts, impeller after coating is heated, be warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, is incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 4
A kind of intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is Cu:12.2 ﹪, Al:9.3 ﹪, Si:5.1 ﹪, Zn:1.4 ﹪, Co:0.52 ﹪, Fe:0.22 ﹪, Ag:0.11 ﹪, Cr:0.14 ﹪, Zr:0.06, La:0.06 ﹪, Ta:0.034 ﹪, B:0.023 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1812 DEG C, pouring temperature is 1753 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of: take 98% dense H 2sO 415 parts, the HCL of 36.5% 22 parts, propanoic acid 1.5 parts, ethylenediamine 2 parts, alkyl imidazoline quaternary ammonium salt 12 parts; 13 parts, water;
Passivating solution consists of: polyimides 1.5 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 15.5 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1.4 parts, Sodium fluoroborate 10.5 parts, 1.5 parts, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 22 parts, 52 parts, water;
Coating external oxidation zirconium series ceramic material layer is carried out to the impeller body after passivation; Zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 75 parts, titanium nitride 32 parts, titanium carbide, 21 parts, chromium oxide 11 parts, heats the impeller after coating, is warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 5
A kind of intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is Cu:12.9 ﹪, Al:9.7 ﹪, Si:5.6 ﹪, Zn:1.9 ﹪, Co:0.57 ﹪, Fe:0.26 ﹪, Ag:0.18 ﹪, Cr:0.19 ﹪, Zr:0.07 ﹪, La:0.07 ﹪, Ta:0.039 ﹪, B:0.028 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1816 DEG C, pouring temperature is 1759 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of: take 98% dense H 2sO 430 parts, the HCL of 36.5% 28 parts, propanoic acid 2.5 parts, ethylenediamine 4.5 parts, alkyl imidazoline quaternary ammonium salt 14 parts; 19 parts, water;
Passivating solution consists of: polyimides 2.5 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 17 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1.8 parts, Sodium fluoroborate 12.5 parts, 3.5 parts, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 24 parts, 58 parts, water;
Coating external oxidation zirconium series ceramic material layer is carried out to the impeller body after passivation; Zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 85 parts, titanium nitride 37 parts, titanium carbide 28 parts, chromium oxide 14.5 parts, impeller after coating is heated, be warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, is incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling, to room temperature, obtains final impeller.

Claims (9)

1. an intracardiac blood pump, it comprises an impeller, and described impeller comprises cast titanium alloy impeller body and impeller body external oxidation zirconium series ceramic material layer,
It is characterized in that, cast titanium alloy impeller body chemical composition is (mass percent): Cu:12-13 ﹪, Al:9-10 ﹪, Si:5-6 ﹪, Zn:1-2 ﹪, Co:0.5-0.6 ﹪, Fe:0.2-0.3 ﹪, Ag:0.1-0.2 ﹪, Cr:0.1-0.2 ﹪, Zr:0.05-0.08 ﹪, La:0.05-0.08 ﹪, Ta:0.03-0.04 ﹪, B:0.02-0.03 ﹪, surplus is Ti and inevitable impurity;
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C; After the demoulding, the impeller body obtained is heat-treated: first heated by impeller, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 9 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 9 hours, after be warming up to 700 DEG C, heating rate 100 DEG C/h, be incubated 7 hours, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 3 hours, after be again cooled to 150 DEG C, rate of temperature fall 40 DEG C/h, be incubated 7 hours, rear air cooling is to room temperature
Afterwards pickling and Passivation Treatment are carried out to impeller body surface, wherein:
Pickle consists of (quality): take 98% dense H 2sO 410-35 part, HCL 20-30 part of 36.5%, propanoic acid 1-3 part, ethylenediamine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part; Water 10-20 part;
Passivating solution consists of (quality): polyimides 1-3 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 15-18 part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1-2 part, Sodium fluoroborate 10-13 part, sulphuric acid 1-4 part, dialkyl dithiophosphoric acid oxygen molybdenum 20-25 part, water 50-60 part;
Coating external oxidation zirconium series ceramic material is carried out to the impeller body after passivation, zirconium oxide series ceramic material layer is formed by being coated in impeller surface, zirconium oxide series ceramic material layer thickness 0.5mm, zirconium oxide series ceramic material composition of layer comprises (quality): zirconium oxide 70-90 part, titanium nitride 30-40 part, titanium carbide 20-30 part, chromium oxide 10-15 part, impeller after coating is heated, be warming up to 750 DEG C, heating rate 200 DEG C/h, be incubated 1 hour, after be cooled to 450 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be again cooled to 150 DEG C, rate of temperature fall 50 DEG C/h, be incubated 8 hours, rear air cooling is to room temperature, obtain final impeller.
2. a kind of intracardiac blood pump as claimed in claim 1, cast titanium alloy impeller body chemical composition is Cu:12 ﹪, Al:9 ﹪, Si:5 ﹪, Zn:1 ﹪, Co:0.5 ﹪, Fe:0.2 ﹪, Ag:0.1 ﹪, Cr:0.1 ﹪, Zr:0.05 ﹪, La:0.05 ﹪, Ta:0.03 ﹪, B:0.02 ﹪, surplus is Ti and inevitable impurity.
3. a kind of intracardiac blood pump as claimed in claim 1, cast titanium alloy impeller body chemical composition is Cu:13 ﹪, Al:10 ﹪, Si:6 ﹪, Zn:2 ﹪, Co:0.6 ﹪, Fe:0.3 ﹪, Ag:0.2 ﹪, Cr:0.2 ﹪, Zr:0.08 ﹪, La:0.08 ﹪, Ta:0.04 ﹪, B:0.03 ﹪, surplus is Ti and inevitable impurity.
4. a kind of intracardiac blood pump as claimed in claim 1, cast titanium alloy impeller body chemical composition is Cu:12.5 ﹪, Al:9.5 ﹪, Si:5.5 ﹪, Zn:1.5 ﹪, Co:0.55 ﹪, Fe:0.25 ﹪, Ag:0.15 ﹪, Cr:0.15 ﹪, Zr:0.06 ﹪, La:0.06 ﹪, Ta:0.035 ﹪, B:0.025 ﹪, surplus is Ti and inevitable impurity.
5. a kind of intracardiac blood pump as claimed in claim 1, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 70 parts, titanium nitride 30 parts, titanium carbide 20 parts, chromium oxide 10 parts.
6. a kind of intracardiac blood pump as claimed in claim 1, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 90 parts, titanium nitride 40 parts, titanium carbide 30 parts, chromium oxide 15 parts.
7. a kind of intracardiac blood pump as claimed in claim 1, zirconium oxide series ceramic material composition of layer comprises: zirconium oxide 80 parts, titanium nitride 35 parts, titanium carbide 25 parts, chromium oxide 13 parts.
8. a kind of intracardiac blood pump as claimed in claim 1, pickle consists of: take 98% dense H 2sO 420 parts, the HCL of 36.5% 25 parts, propanoic acid 2 parts, ethylenediamine 3 parts, alkyl imidazoline quaternary ammonium salt 13 parts; 15 parts, water.
9. a kind of intracardiac blood pump as described in claim 1-9, passivating solution consists of: polyimides 2 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 17 parts, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 1.5 parts, Sodium fluoroborate 12 parts, 3 parts, sulphuric acid, dialkyl dithiophosphoric acid oxygen molybdenum 23 parts, 55 parts, water.
CN201510207488.XA 2015-04-28 2015-04-28 Blood pump in heart Pending CN104771797A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
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US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US20210378678A1 (en) * 2020-06-08 2021-12-09 White Swell Medical Ltd Non-thrombogenic devices for treating edema
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11717670B2 (en) 2017-06-07 2023-08-08 Shifamed Holdings, LLP Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US11229784B2 (en) 2018-02-01 2022-01-25 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US20210378678A1 (en) * 2020-06-08 2021-12-09 White Swell Medical Ltd Non-thrombogenic devices for treating edema

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