CN104862528B - A kind of blood pump in operative cardiac - Google Patents
A kind of blood pump in operative cardiac Download PDFInfo
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- CN104862528B CN104862528B CN201510207456.XA CN201510207456A CN104862528B CN 104862528 B CN104862528 B CN 104862528B CN 201510207456 A CN201510207456 A CN 201510207456A CN 104862528 B CN104862528 B CN 104862528B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0211—Ceramics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Abstract
The present invention discloses a kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, the pump housing includes: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide series ceramic material layer of pump housing inner surface, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body, by at the kind surface-coated titanium nitride series ceramic material layer at impeller different with speed according to impeller contact human body cell, improve material and blood compatibility, by according to the pump housing contact kind inner surface at the pump housing different with speed of human body cell and outer surface titanium carbide series ceramic material and zirconium oxide series ceramic material layer, the performance requirements such as the anti-hemolysis of raising material and antithrombotic.
Description
Technical field
The present invention relates to a kind of blood pump in operative cardiac, belongs to implantable pump, belongs to technical field of medical instruments.
Background technology
Clinically, the patient for heart failure typically requires and treats by artificial mechanical's auxiliary device.The most main
The heart assistance therapy equipment wanted has blood pump.The existing blood pump in home and abroad is mainly implantable auxiliary blood pump, confirmed blood pump
Damage to blood constituent is mainly haemolysis and thrombosis two kinds, and the former refers to erythrocytic rupturing, and causes intracellular blood red egg
Dissociate in vain in blood plasma；The latter refers to that platelet is assembled after being activated, and is deposited on blood contacting surface.Haemolysis and thrombosis all can be made
Become the physiologic derangement of receptor, crisis life time serious.The existing pump housing and impeller material have been difficult to meet anti-hemolysis and antithrombotic
Deng performance requirement.
Summary of the invention
A kind of technique that the present invention is aiming at the problems referred to above and proposes is simple, low cost, anti-hemolysis and antithrombotic property
The good blood pump in operative cardiac.
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag
Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface
The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14-15, Al:6-7, Fe:4-5, Si:
1-2, Mg 1-2, Ni 0.7-0.8, Cu:0.5-0.6, Cd:0.2-0.3, Zr:0.07-0.08, Ce:0.03-
0.04, Mn: 0.05-0.06, V:0.06-0.07, B:0.08-0.09, surplus is Ti and the most miscellaneous
Matter；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C；After the demoulding, the pump housing obtained is carried out at heat
Reason: first the pump housing is heated, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C,
Rate of temperature fall 100 DEG C/h, is incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after again
Secondary be cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/little
Time, be incubated 6 hours, rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO440-50 part, HCL 15-20 part of 36.5%, propanoic acid 1-3
Part, ethylenediamine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part；Water 10-20 part；
Passivating solution consists of (weight): polyimides 10-15 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane
4-10 part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2-3 part, Sodium fluoroborate 10-13 part, sulphuric acid 1-4
Part, dialkyl dithiophosphoric acid oxygen molybdenum 6-7 part, water 25-35 part；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 50-60 part, titanium boride 20-30 part, titanium carbide 20-30 part, silicon oxide 1-2 part, the pump housing after coating is heated, rises
Temperature to 750 DEG C, heating rate 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation 3
Hour, after be again cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 15-20 part, chromium carbide 10 parts, titanium oxide 5-8 part, the pump housing after coating is heated, is warming up to 600
DEG C, heating rate 200 DEG C/h, be incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after
Again it is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8-9, Al:5-6, Si:3-4, Cu:
2-3, Fe:0.6-0.7, Mg:0.5-0.6, Ag:0.5-0.7, Cr:0.1-0.2, Zr:0.05-0.08, La:
0.03-0.04, Ta:0.03-0.04, B:0.02-0.03, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C；After the demoulding, the impeller body obtained enters
Row heat treatment: first heated by impeller, is warming up to 850 DEG C, heating rate 300 DEG C/h, is incubated 7 hours, after be cooled to
700 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, insulation is 5 little
Time, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40
DEG C/h, be incubated 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO460-70 part, HCL 1-10 part of 36.5%, propanoic acid 5-10 part, second two
Amine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part；Water 10-20 part；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 4-10 part,
N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 8-15 part, Sodium fluoroborate 10-13 part, sulphuric acid 8-9 part, two
Alkyl dithiophosphoric acid oxygen molybdenum 20-25 part, water 25-35 part；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 60-70 part, titanium carbide, 20-30 part, zirconium oxide 10 parts, silicon oxide 1-2 part, the impeller after coating is heated, rises
Temperature to 800 DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation 3
Hour, after be again cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, be incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Described a kind of blood pump in operative cardiac, cast titanium alloy pump housing chemical composition is: Zn:14, Al:
6, Fe:4, Si:1, Mg 1, Ni 0.7, Cu:0.5, Cd:0.2, Zr:0.07, Ce:0.03, Mn:
0.05, V:0.06, B:0.08, surplus is Ti and inevitable impurity.
Described a kind of blood pump in operative cardiac, cast titanium alloy pump housing chemical composition is: Zn:15,
Al:7, Fe:5, Si:2, Mg 2, Ni 0.8, Cu:0.6, Cd:0.3, Zr:0.08, Ce:
0.04, Mn: 0.06, V:0.07, B:0.09, surplus is Ti and inevitable impurity.
Described a kind of blood pump in operative cardiac, cast titanium alloy pump housing chemical composition is: Zn:14.5,
Al:6.5, Fe:4.5, Si:1.5, Mg 1.5, Ni 0.75, Cu:0.55, Cd:0.25, Zr:0.075,
Ce:0.035, Mn: 0.055, V:0.065, B:0.085, surplus is Ti and inevitable impurity.
Described a kind of blood pump in operative cardiac, cast titanium alloy impeller body chemical composition be Zn:8,
Al:5, Si:3, Cu:2, Fe:0.6, Mg:0.5, Ag:0.5, Cr:0.1, Zr:0.05, La:0.03,
Ta:0.03, B:0.02, surplus is Ti and inevitable impurity.
Described a kind of blood pump in operative cardiac, cast titanium alloy impeller body chemical composition be Zn:9,
Al:6, Si:4, Cu:3, Fe:0.7, Mg:0.6, Ag:0.7, Cr:0.2, Zr:0.08,
La:0.04, Ta:0.04, B:0.03, surplus is Ti and inevitable impurity.
Described a kind of blood pump in operative cardiac, cast titanium alloy impeller body chemical composition is Zn:
8.5, Al:5.5, Si:3.5, Cu:2.5, Fe:0.65, Mg:0.55, Ag:0.6, Cr:0.15, Zr:
0.06, La:0.035, Ta:0.035, B:0.025, surplus is Ti and inevitable impurity.
A kind of blood pump in operative cardiac stated, titanium nitride series ceramic material composition of layer includes: titanium nitride 60 parts,
Titanium carbide, 20 parts, zirconium oxide 10 parts, silicon oxide 1 part.
Described a kind of blood pump in operative cardiac, titanium nitride series ceramic material composition of layer includes: titanium nitride 70
Part, titanium carbide, 30 parts, zirconium oxide 10 parts, silicon oxide 2 parts.
Described a kind of blood pump in operative cardiac, titanium nitride series ceramic material composition of layer includes: titanium nitride 65
Part, titanium carbide 25 parts, zirconium oxide 10 parts, silicon oxide 1.5 parts.
The manufacture method of a kind of blood pump in operative cardiac, blood pump includes the leaf in a pump housing and the described pump housing
Wheel, the pump housing includes: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide of pump housing inner surface
Series ceramic material layer, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14-15, Al:6-7, Fe:4-5, Si:
1-2, Mg 1-2, Ni 0.7-0.8, Cu:0.5-0.6, Cd:0.2-0.3, Zr:0.07-0.08, Ce:0.03-
0.04, Mn: 0.05-0.06, V:0.06-0.07, B:0.08-0.09, surplus is Ti and the most miscellaneous
Matter；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C；After the demoulding, the pump housing obtained is carried out at heat
Reason: first the pump housing is heated, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C,
Rate of temperature fall 100 DEG C/h, is incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after again
Secondary be cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/little
Time, be incubated 6 hours, rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO440-50 part, HCL 15-20 part of 36.5%, propanoic acid 1-3
Part, ethylenediamine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part；Water 10-20 part；
Passivating solution consists of (weight): polyimides 10-15 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane
4-10 part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2-3 part, Sodium fluoroborate 10-13 part, sulphuric acid 1-4
Part, dialkyl dithiophosphoric acid oxygen molybdenum 6-7 part, water 25-35 part；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 50-60 part, titanium boride 20-30 part, titanium carbide 20-30 part, silicon oxide 1-2 part, the pump housing after coating is heated, rises
Temperature to 750 DEG C, heating rate 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation 3
Hour, after be again cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 15-20 part, chromium carbide 10 parts, titanium oxide 5-8 part, the pump housing after coating is heated, is warming up to 600
DEG C, heating rate 200 DEG C/h, be incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after
Again it is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8-9, Al:5-6, Si:3-4, Cu:
2-3, Fe:0.6-0.7, Mg:0.5-0.6, Ag:0.5-0.7, Cr:0.1-0.2, Zr:0.05-0.08, La:
0.03-0.04, Ta:0.03-0.04, B:0.02-0.03, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C；After the demoulding, the impeller body obtained enters
Row heat treatment: first heated by impeller, is warming up to 850 DEG C, heating rate 300 DEG C/h, is incubated 7 hours, after be cooled to
700 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, insulation is 5 little
Time, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40
DEG C/h, be incubated 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO460-70 part, HCL 1-10 part of 36.5%, propanoic acid 5-10 part, second two
Amine 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part；Water 10-20 part；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 4-10 part,
N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 8-15 part, Sodium fluoroborate 10-13 part, sulphuric acid 8-9 part, two
Alkyl dithiophosphoric acid oxygen molybdenum 20-25 part, water 25-35 part；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 60-70 part, titanium carbide, 20-30 part, zirconium oxide 10 parts, silicon oxide 1-2 part, the impeller after coating is heated, rises
Temperature to 800 DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation 3
Hour, after be again cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, be incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Upper described pump housing inner surface is that blood passes through to touch the part on pump body surface when pump is internal, the pump housing its
Remaining part is divided into pump housing outer surface.
State summary of the invention having the beneficial effects that relative to prior art: 1) composition of titanium alloy is simple；Intensity is higher；2)
Titanium alloy to this composition carries out the surface treatment procedure of pickling and passivation, it is to avoid the problems such as any surface stain occurs, makes to obtain
Obtain surface clean and tidy；3) by the kind surface-coated titanium nitride at impeller different with speed according to impeller contact human body cell
Series ceramic material layer, improves material and blood compatibility.4) by according to the pump housing contact kind of human body cell and speed not
With at the inner surface of the pump housing and outer surface titanium carbide series ceramic material and zirconium oxide series ceramic material layer, improve the anti-of material
The performance requirement such as haemolysis and antithrombotic.
Detailed description of the invention
In order to the technical characteristic of the present invention, purpose and effect are more clearly understood from, now describe the present invention's in detail
Detailed description of the invention.
Embodiment 1
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag
Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface
The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14, Al:6, Fe:4, Si:1, Mg
1, Ni 0.7, Cu:0.5, Cd:0.2, Zr:0.07, Ce:0.03, Mn: 0.05, V:0.06, B:
0.08, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1810 DEG C, pouring temperature is 1750 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first by pump
Body heats, and is warming up to 950 DEG C, heating rate 300 DEG C/h, is incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100
DEG C/h, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450
DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours,
Rear air cooling to room temperature,
Afterwards its surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO440 parts, the HCL of 36.5% 15 parts, propanoic acid 1 part, ethylenediamine 1
Part, alkyl imidazoline quaternary ammonium salt 10 parts；10 parts of water；
Passivating solution consists of (weight): polyimides 10 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 4
Part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2 parts, Sodium fluoroborate 10 parts, 1 part of sulphuric acid, dialkyl group two
D2EHDTPA oxygen molybdenum 6 parts, 25 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 50 parts, titanium boride 20 parts, titanium carbide 20 parts, silicon oxide 1 part, heats the pump housing after coating, is warming up to 750 DEG C, rise
Temperature speed 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again
Be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 15 parts, chromium carbide 10 parts, titanium oxide 5 parts, heats the pump housing after coating, is warming up to 600 DEG C, heat up
Speed 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again drop
Warm to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8, Al:5, Si:3, Cu:2,
Fe:0.6, Mg:0.5, Ag:0.5, Cr:0.1, Zr:0.05, La:0.03, Ta:0.03, B:0.02, remaining
Amount is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1810 DEG C, pouring temperature is 1750 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first
First impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling
Speed 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again drop
Temperature to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, guarantor
Temperature 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO460 parts, the HCL of 36.5% 1 part, propanoic acid 5 parts, ethylenediamine 1 part, alkane
Base imidazoline quaternary ammonium salt 10 parts；10 parts of water；
Passivating solution consists of: polyimides 7 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 4 parts, N-(2-
Amino-ethyl)-3-amino propyl methyl dimethoxysilane 8 parts, Sodium fluoroborate 10 parts, 8 parts of sulphuric acid, dialkyl dithiophosphoric acid
Oxygen molybdenum 20 parts, 25 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 60 parts, titanium carbide, 20 parts, zirconium oxide 10 parts, silicon oxide 1 part, heats the impeller after coating, is warming up to 800
DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 2
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag
Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface
The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:15, Al:7, Fe:5, Si:2,
Mg 2, Ni 0.8, Cu:0.6, Cd:0.3, Zr:0.08, Ce:0.04, Mn: 0.06, V:
0.07, B:0.09, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1820 DEG C, pouring temperature is 1760 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first will
The pump housing heats, and is warming up to 950 DEG C, heating rate 300 DEG C/h, is incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall
100 DEG C/h, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to
450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, insulation is 6 little
Time, rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO450 parts, the HCL of 36.5% 20 parts, propanoic acid 3 parts, ethylenediamine 5
Part, alkyl imidazoline quaternary ammonium salt 15 parts；20 parts of water；
Passivating solution consists of (weight): polyimides 15 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 10
Part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 3 parts, Sodium fluoroborate 13 parts, 4 parts of sulphuric acid, dialkyl group two
D2EHDTPA oxygen molybdenum 7 parts, 35 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 60 parts, titanium boride 30 parts, titanium carbide 30 parts, silicon oxide 2 parts, heats the pump housing after coating, is warming up to 750 DEG C, rise
Temperature speed 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again
Be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 20 parts, chromium carbide 10 parts, titanium oxide 8 parts, heats the pump housing after coating, is warming up to 600 DEG C, heat up
Speed 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again drop
Warm to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:9, Al:6, Si:4, Cu:
3, Fe:0.7, Mg:0.6, Ag:0.7, Cr:0.2, Zr:0.08, La:0.04, Ta:0.04,
B:0.03, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1820 DEG C, pouring temperature is 1760 DEG C；After the demoulding, the impeller body obtained carries out heat treatment:
First impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, fall
Temperature speed 100 DEG C/h, be incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again
Be cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h,
Be incubated 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO470 parts, the HCL of 36.5% 10 parts, propanoic acid 10 parts, ethylenediamine 5 parts,
Alkyl imidazoline quaternary ammonium salt 15 parts；20 parts of water；
Passivating solution consists of: polyimides 8 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 10 parts, N-(2-
Amino-ethyl)-3-amino propyl methyl dimethoxysilane 15 parts, Sodium fluoroborate 13 parts, 9 parts of sulphuric acid, dialkyl dithio phosphorus
Acid oxygen molybdenum 25 parts, 35 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 70 parts, titanium carbide, 30 parts, zirconium oxide 10 parts, silicon oxide 2 parts, heats the impeller after coating, is warming up to 800
DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 3
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag
Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface
The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14.5, Al:6.5, Fe:4.5, Si:
1.5, Mg 1.5, Ni 0.75, Cu:0.55, Cd:0.25, Zr:0.075, Ce:0.035, Mn:
0.055, V:0.065, B:0.085, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1815 DEG C, pouring temperature is 1755 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first by pump
Body heats, and is warming up to 950 DEG C, heating rate 300 DEG C/h, is incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100
DEG C/h, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450
DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours,
Rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO445 parts, the HCL of 36.5% 17 parts, propanoic acid 2 parts, ethylenediamine 3
Part, alkyl imidazoline quaternary ammonium salt 13 parts；15 parts of water；
Passivating solution consists of (weight): polyimides 13 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 7
Part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.5 parts, Sodium fluoroborate 12 parts, 3 parts of sulphuric acid, dialkyl group
Phosphordithiic acid oxygen molybdenum 6.5 parts, 30 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 55 parts, titanium boride 25 parts, titanium carbide 25 parts, silicon oxide 1.5 parts, the pump housing after coating is heated, is warming up to 750 DEG C,
Heating rate 250 DEG C/h, is incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again
Secondary be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 17 parts, chromium carbide 10 parts, titanium oxide 6 parts, heats the pump housing after coating, is warming up to 600 DEG C, heat up
Speed 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again drop
Warm to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8.5, Al:5.5, Si:3.5, Cu:
2.5, Fe:0.65, Mg:0.55, Ag:0.6, Cr:0.15, Zr:0.07, La:0.035, Ta:0.035,
B:0.025, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1815 DEG C, pouring temperature is 1755 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first
First impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling
Speed 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again drop
Temperature to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, guarantor
Temperature 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO465 parts, the HCL of 36.5% 5 parts, propanoic acid 7 parts, ethylenediamine 3 parts, alkane
Base imidazoline quaternary ammonium salt 13 parts；15 parts of water；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 7 parts, N-
(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 12 parts, Sodium fluoroborate 12 parts, 8.5 parts of sulphuric acid, dialkyl disulfides
For phosphoric acid oxygen molybdenum 23 parts, 30 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 65 parts, titanium carbide, 25 parts, zirconium oxide 10 parts, silicon oxide 1.5 parts, heats the impeller after coating, is warming up to
800 DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation is 3 little
Time, after be again cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, be incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 4
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag
Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface
The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14.2, Al:6.3, Fe:4.4, Si:
1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.25, Zr:0.074, Ce:0.033, Mn:
0.052, V:0.061, B:0.082, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first by pump
Body heats, and is warming up to 950 DEG C, heating rate 300 DEG C/h, is incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100
DEG C/h, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450
DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours,
Rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO443 parts, the HCL of 36.5% 17 parts, propanoic acid 1.3 parts, second two
Amine 1.4 parts, alkyl imidazoline quaternary ammonium salt 11 parts；11 parts of water；
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5
Part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.4 parts, Sodium fluoroborate 10.2 parts, 1.3 parts of sulphuric acid, two
Alkyl dithiophosphoric acid oxygen molybdenum 6.4 parts, 26 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 52 parts, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.4 parts, the pump housing after coating is heated, is warming up to 750 DEG C,
Heating rate 250 DEG C/h, is incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again
Secondary be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 5.4 parts, heats the pump housing after coating, is warming up to 600 DEG C, rise
Temperature speed 200 DEG C/h, be incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again
It is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8.3, Al:5.2, Si:3.1, Cu:
2.4, Fe:0.63, Mg:0.51, Ag:0.54, Cr:0.12, Zr:0.054, La:0.033, Ta:
0.032, B:0.024, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1814 DEG C, pouring temperature is 1753 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first
First impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling
Speed 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again drop
Temperature to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, guarantor
Temperature 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO462 parts, the HCL of 36.5% 3 parts, propanoic acid 6 parts, ethylenediamine 1.3 parts, alkane
Base imidazoline quaternary ammonium salt 11.3 parts；11 parts of water；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-
(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 9 parts, Sodium fluoroborate 11 parts, 8.3 parts of sulphuric acid, dialkyl disulfides
For phosphoric acid oxygen molybdenum 21 parts, 27 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 68 parts, titanium carbide 29 parts, zirconium oxide 10 parts, silicon oxide 1.8 parts, heats the impeller after coating, is warming up to 800
DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Embodiment 5
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag
Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface
The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14.7, Al:6.8, Fe:4.9, Si:
1.6, Mg 1.7, Ni 0.78, Cu:0.59, Cd:0.26, Zr:0.077, Ce:0.038, Mn:
0.058, V:0.067, B:0.088, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1819 DEG C, pouring temperature is 1757 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first by pump
Body heats, and is warming up to 950 DEG C, heating rate 300 DEG C/h, is incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100
DEG C/h, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450
DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours,
Rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO448 parts, the HCL of 36.5% 19 parts, propanoic acid 2.4 parts, second two
Amine 4 parts, alkyl imidazoline quaternary ammonium salt 14 parts；19 parts of water；
Passivating solution consists of (weight): polyimides 14 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 9
Part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.9 parts, Sodium fluoroborate 12.7 parts, 3.8 parts of sulphuric acid, two
Alkyl dithiophosphoric acid oxygen molybdenum 6.8 parts, 34 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Oxygen is formed by being coated in pump housing outer surface
Changing zirconium series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: oxidation
Zirconium 58 parts, titanium boride 29 parts, titanium carbide 27 parts, silicon oxide 1.7 parts, the pump housing after coating is heated, is warming up to 750 DEG C,
Heating rate 250 DEG C/h, is incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again
Secondary be cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Carbonization is formed by being coated in pump housing inner surface
Titanium series ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide
90 parts, titanium nitride 18 parts, chromium carbide 10 parts, titanium oxide 7.8 parts, heats the pump housing after coating, is warming up to 600 DEG C, rise
Temperature speed 200 DEG C/h, be incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again
It is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing.
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8.7, Al:5.9, Si:3.7, Cu:
2.6, Fe:0.67, Mg:0.57, Ag:0.58, Cr:0.18, Zr:0.057, La:0.038, Ta:
0.039, B:0.028, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material
Melting, cast: smelting temperature: 1817 DEG C, pouring temperature is 1757 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first
First impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling
Speed 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again drop
Temperature to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, guarantor
Temperature 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO469 parts, the HCL of 36.5% 9 parts, propanoic acid 9 parts, ethylenediamine 4 parts, alkane
Base imidazoline quaternary ammonium salt 14 parts；18 parts of water；
Passivating solution consists of: polyimides 7.8 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 9 parts, N-
(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 14 parts, Sodium fluoroborate 12.9 parts, 8.7 parts of sulphuric acid, dialkyl group two
D2EHDTPA oxygen molybdenum 24 parts, 34 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Formed by being coated in impeller surface
Outer titanium nitride series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes:
Titanium nitride 68 parts, titanium carbide 28 parts, zirconium oxide 10 parts, silicon oxide 1.7 parts, heats the impeller after coating, is warming up to 800
DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after
Again it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Claims (1)
1. the blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, and the pump housing includes:
The cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide series ceramic material of pump housing inner surface
Layer, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is (percentage by weight): Zn:14-15, Al:6-7, Fe:4-
5, Si:1-2, Mg 1-2, Ni 0.7-0.8, Cu:0.5-0.6, Cd:0.2-0.3, Zr:0.07-0.08,
Ce:0.03-0.04, Mn: 0.05-0.06, V:0.06-0.07, B:0.08-0.09, surplus is Ti and can not keep away
The impurity exempted from；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters
Note: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first
First the pump housing is heated, is warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, cooling
Speed 100 DEG C/h, is incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after again drop
Temperature to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, guarantor
Temperature 6 hours, rear air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO440-50 part, hydrochloric acid 15-20 part of 36.5%, propanoic acid 1-3 part, second
Diamidogen 1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part；Water 10-20 part；
Passivating solution consists of (weight): polyimides 10-15 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 4-10
Part, N-(2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2-3 part, Sodium fluoroborate 10-13 part, sulphuric acid 1-4 part,
Dialkyl dithiophosphoric acid oxygen molybdenum 6-7 part, water 25-35 part；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Zirconium oxide is formed by being coated in pump housing outer surface
Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer is by zirconium oxide 50-
60 parts, titanium boride 20-30 part, titanium carbide 20-30 part, silicon oxide 1-2 part forms, and is heated by the pump housing after coating, heats up
To 750 DEG C, heating rate 250 DEG C/h, be incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation is 3 little
Time, after be again cooled to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Titanium carbide system is formed by being coated in pump housing inner surface
Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide 90
Part, titanium nitride 15-20 part, chromium carbide 10 parts, titanium oxide 5-8 part, the pump housing after coating is heated, is warming up to 600 DEG C,
Heating rate 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again
Secondary it is cooled to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing,
It is characterized in that, cast titanium alloy impeller body chemical composition is (percentage by weight): Zn:8-9, Al:5-6, Si:
3-4, Cu:2-3, Fe:0.6-0.7, Mg:0.5-0.6, Ag:0.5-0.7, Cr:0.1-0.2, Zr:0.05-
0.08, La:0.03-0.04, Ta:0.03-0.04, B:0.02-0.03, surplus is Ti and the most miscellaneous
Matter；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts
Refining, cast: smelting temperature: 1810-1820 DEG C, pouring temperature is 1750-1760 DEG C；After the demoulding, the impeller body obtained is carried out
Heat treatment: first heated by impeller, is warming up to 850 DEG C, heating rate 300 DEG C/h, is incubated 7 hours, after be cooled to
700 DEG C, rate of temperature fall 100 DEG C/h, be incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, insulation is 5 little
Time, after be again cooled to 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40
DEG C/h, be incubated 5 hours, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense H2SO460-70 part, hydrochloric acid 1-10 part of 36.5%, propanoic acid 5-10 part, ethylenediamine
1-5 part, alkyl imidazoline quaternary ammonium salt 10-15 part；Water 10-20 part；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 4-10 part, N-(2-
Amino-ethyl)-3-amino propyl methyl dimethoxysilane 8-15 part, Sodium fluoroborate 10-13 part, sulphuric acid 8-9 part, dialkyl group two
D2EHDTPA oxygen molybdenum 20-25 part, water 25-35 part；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Outer nitrogen is formed by being coated in impeller surface
Changing titanium series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes: nitridation
Titanium 60-70 part, titanium carbide 20-30 part, zirconium oxide 10 parts, silicon oxide 1-2 part, the impeller after coating is heated, is warming up to
800 DEG C, heating rate 200 DEG C/h, be incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, insulation is 3 little
Time, after be again cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, be incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510207456.XA CN104862528B (en) | 2015-04-28 | 2015-04-28 | A kind of blood pump in operative cardiac |
| CN201610360528.9A CN106075621A (en) | 2015-04-28 | 2015-04-28 | A kind of implantation blood pump in operative cardiac |
| CN201610370562.4A CN105833370A (en) | 2015-04-28 | 2015-04-28 | Blood pump having good anti-hemolysis and anti-thrombosis properties and used in surgical heart |
Applications Claiming Priority (1)
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| CN201510207456.XA CN104862528B (en) | 2015-04-28 | 2015-04-28 | A kind of blood pump in operative cardiac |
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| CN201610360528.9A Division CN106075621A (en) | 2015-04-28 | 2015-04-28 | A kind of implantation blood pump in operative cardiac |
| CN201610370562.4A Division CN105833370A (en) | 2015-04-28 | 2015-04-28 | Blood pump having good anti-hemolysis and anti-thrombosis properties and used in surgical heart |
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| CN104862528A CN104862528A (en) | 2015-08-26 |
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| CN201610370562.4A Pending CN105833370A (en) | 2015-04-28 | 2015-04-28 | Blood pump having good anti-hemolysis and anti-thrombosis properties and used in surgical heart |
| CN201610360528.9A Pending CN106075621A (en) | 2015-04-28 | 2015-04-28 | A kind of implantation blood pump in operative cardiac |
| CN201510207456.XA Active CN104862528B (en) | 2015-04-28 | 2015-04-28 | A kind of blood pump in operative cardiac |
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| CN201610370562.4A Pending CN105833370A (en) | 2015-04-28 | 2015-04-28 | Blood pump having good anti-hemolysis and anti-thrombosis properties and used in surgical heart |
| CN201610360528.9A Pending CN106075621A (en) | 2015-04-28 | 2015-04-28 | A kind of implantation blood pump in operative cardiac |
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| CA3066361A1 (en) | 2017-06-07 | 2018-12-13 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
| CN111556763B (en) | 2017-11-13 | 2023-09-01 | 施菲姆德控股有限责任公司 | Intravascular fluid movement device and system |
| CN107955167B (en) * | 2017-12-07 | 2020-08-18 | 陕西科技大学 | Preparation method of high-performance polyimide titanium carbide nanosheet composite material |
| EP3746149A4 (en) | 2018-02-01 | 2021-10-27 | Shifamed Holdings, LLC | Intravascular blood pumps and methods of use and manufacture |
| WO2021011473A1 (en) | 2019-07-12 | 2021-01-21 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
| WO2021016372A1 (en) | 2019-07-22 | 2021-01-28 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
| US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
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| US5477864A (en) * | 1989-12-21 | 1995-12-26 | Smith & Nephew Richards, Inc. | Cardiovascular guidewire of enhanced biocompatibility |
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| CN101015716A (en) * | 2007-03-09 | 2007-08-15 | 清华大学 | Implanted non-contact minisize axial-flow blood pump |
| FR2982618B1 (en) * | 2011-11-10 | 2014-08-01 | Institut Nat Des Sciences Appliquees De Rennes Insa De Rennes | METHOD FOR MANUFACTURING TITANIUM ALLOY FOR BIOMEDICAL DEVICES |
| CN103331584B (en) * | 2013-07-16 | 2016-01-20 | 富威科技（吴江）有限公司 | A kind of production technology of photovoltaic solar copper strips |
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|---|---|---|---|---|
| CN203822654U (en) * | 2014-04-15 | 2014-09-10 | 高涵文 | Stainless steel magnetic drive pump capable of approximate zero inner leakage |
| CN104072137A (en) * | 2014-05-24 | 2014-10-01 | 芜湖浙鑫新能源有限公司 | Ceramic core for water pump impeller |
| CN104373357A (en) * | 2014-11-14 | 2015-02-25 | 中国科学院苏州生物医学工程技术研究所 | Medical magnetic drive centrifugal pump based on logarithmic spiral impeller and sliding bearings |
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| CN105833370A (en) | 2016-08-10 |
| CN106075621A (en) | 2016-11-09 |
| CN104862528A (en) | 2015-08-26 |
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