CN105833370A - Blood pump having good anti-hemolysis and anti-thrombosis properties and used in surgical heart - Google Patents

Blood pump having good anti-hemolysis and anti-thrombosis properties and used in surgical heart Download PDF

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CN105833370A
CN105833370A CN201610370562.4A CN201610370562A CN105833370A CN 105833370 A CN105833370 A CN 105833370A CN 201610370562 A CN201610370562 A CN 201610370562A CN 105833370 A CN105833370 A CN 105833370A
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parts
incubated
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pump housing
ceramic material
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傅风荣
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0211—Ceramics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)

Abstract

The invention provides a blood pump having good anti-hemolysis and anti-thrombosis properties and used in a surgical heart. The blood pump comprises a pump body and an impeller in the pump body, wherein the pump body comprises a casting titanium alloy pump body; the impeller comprises a casting titanium alloy impeller body and a titanium nitride series ceramic material layer outside the impeller body; a titanium carbide series ceramic material layer and a zirconium oxide series ceramic material layer are coated on the inner surface and the outer surface of the pump body according to types of human body cells contacted with the pump body at different speeds, so that the requirements on the anti-hemolysis and anti-thrombosis properties and the like of materials are improved.

Description

A kind of anti-hemolysis and the good blood pump in operative cardiac of antithrombotic property
Technical field
The present invention relates to a kind of blood pump in operative cardiac, belongs to implantable pump, belongs to technical field of medical instruments.
Background technology
Clinically, the patient for heart failure typically requires and treats by artificial mechanical's auxiliary device.The most main The heart assistance therapy equipment wanted has blood pump.The existing blood pump in home and abroad is mainly implantable auxiliary blood pump, confirmed blood pump Damage to blood constituent is mainly haemolysis and thrombosis two kinds, and the former refers to erythrocytic rupturing, and causes intracellular blood red egg Dissociate in vain in blood plasma；The latter refers to that platelet is assembled after being activated, and is deposited on blood contacting surface.Haemolysis and thrombosis all can be made Become the physiologic derangement of receptor, crisis life time serious.The existing pump housing and impeller material have been difficult to meet anti-hemolysis and antithrombotic Deng performance requirement.
Summary of the invention
A kind of technique that the present invention is aiming at the problems referred to above and proposes is simple, low cost, anti-hemolysis and antithrombotic property The good blood pump in operative cardiac.
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, pump housing bag Include: the cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide system pottery material of pump housing inner surface The bed of material, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14.2, Al:6.3, Fe:4.4, Si:1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.25, Zr:0.074, Ce:0.033, Mn: 0.052, V: 0.061, B:0.082, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters Note: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first entered by the pump housing Row heating, be warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100 DEG C/ Hour, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450 DEG C, Rate of temperature fall 50 DEG C/h, is incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours, after Air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO443 parts, the HCL of 36.5% 17 parts, propanoic acid 1.3 parts, ethylenediamine 1.4 parts, alkyl imidazoline quaternary ammonium salt 11 parts；11 parts of water；
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N- (2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.4 parts, Sodium fluoroborate 10.2 parts, 1.3 parts of sulphuric acid, dialkyl group Phosphordithiic acid oxygen molybdenum 6.4 parts, 26 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Zirconium oxide is formed by being coated in pump housing outer surface Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: zirconium oxide 52 Part, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.4 parts, heats the pump housing after coating, is warming up to 750 DEG C, heat up Speed 250 DEG C/h, is incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again drop Temperature to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Titanium carbide system is formed by being coated in pump housing inner surface Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide 90 Part, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 5.4 parts, heats the pump housing after coating, is warming up to 600 DEG C, heat up Speed 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again drop Warm to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing,
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8.3, Al:5.2, Si:3.1, Cu: 2.4, Fe:0.63, Mg:0.51, Ag:0.54, Cr:0.12, Zr:0.054, La:0.033, Ta: 0.032, B:0.024, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts Refining, cast: smelting temperature: 1814 DEG C, pouring temperature is 1753 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first Impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling speed Rate 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again lower the temperature To 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, be incubated 5 Hour, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense (H2SO4) 62 parts, (HCL) of 36.5% 3 parts, propanoic acid 6 parts, ethylenediamine 1.3 parts, Alkyl imidazoline quaternary ammonium salt 11.3 parts；11 parts of water；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-(2-ammonia Base ethyl)-3-amino propyl methyl dimethoxysilane 9 parts, Sodium fluoroborate 11 parts, 8.3 parts of sulphuric acid, dialkyl dithiophosphoric acid Oxygen molybdenum 21 parts, 27 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Outer nitrogen is formed by being coated in impeller surface Changing titanium series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes: nitridation Titanium 68 parts, titanium carbide 29 parts, zirconium oxide 10 parts, silicon oxide 1.8 parts, the impeller after coating is heated, is warming up to 800 DEG C, Heating rate 200 DEG C/h, is incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again Secondary it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
Upper described pump housing inner surface is that blood passes through to touch the part on pump body surface when pump is internal, the pump housing its Remaining part is divided into pump housing outer surface.
State summary of the invention having the beneficial effects that relative to prior art: 1) composition of titanium alloy is simple；Intensity is higher；2) Titanium alloy to this composition carries out the surface treatment procedure of pickling and passivation, it is to avoid the problems such as any surface stain occurs, makes to obtain Obtain surface clean and tidy；3) by the kind surface-coated titanium nitride at impeller different with speed according to impeller contact human body cell Series ceramic material layer, improves material and blood compatibility.4) by according to the pump housing contact kind of human body cell and speed not With at the inner surface of the pump housing and outer surface titanium carbide series ceramic material and zirconium oxide series ceramic material layer, improve the anti-of material The performance requirement such as haemolysis and antithrombotic.
Detailed description of the invention
In order to the technical characteristic of the present invention, purpose and effect are more clearly understood from, now describe the present invention's in detail Detailed description of the invention.
Embodiment 1
A kind of blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, and the pump housing includes: casting Make the titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide series ceramic material layer of pump housing inner surface, Impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14.2, Al:6.3, Fe:4.4, Si:1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.25, Zr:0.074, Ce:0.033, Mn: 0.052, V: 0.061, B:0.082, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters Note: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first entered by the pump housing Row heating, be warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100 DEG C/ Hour, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450 DEG C, Rate of temperature fall 50 DEG C/h, is incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours, after Air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO443 parts, the HCL of 36.5% 17 parts, propanoic acid 1.3 parts, ethylenediamine 1.4 parts, alkyl imidazoline quaternary ammonium salt 11 parts；11 parts of water；
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N- (2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.4 parts, Sodium fluoroborate 10.2 parts, 1.3 parts of sulphuric acid, dialkyl group Phosphordithiic acid oxygen molybdenum 6.4 parts, 26 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Zirconium oxide is formed by being coated in pump housing outer surface Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: zirconium oxide 52 Part, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.4 parts, heats the pump housing after coating, is warming up to 750 DEG C, heat up Speed 250 DEG C/h, is incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again drop Temperature to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Titanium carbide system is formed by being coated in pump housing inner surface Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide 90 Part, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 5.4 parts, heats the pump housing after coating, is warming up to 600 DEG C, heat up Speed 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again drop Warm to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing,
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8.3, Al:5.2, Si:3.1, Cu: 2.4, Fe:0.63, Mg:0.51, Ag:0.54, Cr:0.12, Zr:0.054, La:0.033, Ta: 0.032, B:0.024, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts Refining, cast: smelting temperature: 1814 DEG C, pouring temperature is 1753 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first Impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling speed Rate 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again lower the temperature To 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, be incubated 5 Hour, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense (H2SO4) 62 parts, (HCL) of 36.5% 3 parts, propanoic acid 6 parts, ethylenediamine 1.3 parts, Alkyl imidazoline quaternary ammonium salt 11.3 parts；11 parts of water；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-(2-ammonia Base ethyl)-3-amino propyl methyl dimethoxysilane 9 parts, Sodium fluoroborate 11 parts, 8.3 parts of sulphuric acid, dialkyl dithiophosphoric acid Oxygen molybdenum 21 parts, 27 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Outer nitrogen is formed by being coated in impeller surface Changing titanium series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes: nitridation Titanium 68 parts, titanium carbide 29 parts, zirconium oxide 10 parts, silicon oxide 1.8 parts, the impeller after coating is heated, is warming up to 800 DEG C, Heating rate 200 DEG C/h, is incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again Secondary it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.

Claims (1)

1. the blood pump in operative cardiac, blood pump includes the impeller in a pump housing and the described pump housing, and the pump housing includes: The cast titanium alloy pump housing, the zirconium oxide series ceramic material layer of pump housing outer surface and the titanium carbide series ceramic material of pump housing inner surface Layer, impeller includes cast titanium alloy impeller body and the outer titanium nitride series ceramic material layer of impeller body,
It is characterized in that, cast titanium alloy pump housing chemical composition is: Zn:14.2, Al:6.3, Fe:4.4, Si:1.1, Mg 1.2, Ni 0.73, Cu:0.54, Cd:0.25, Zr:0.074, Ce:0.033, Mn: 0.052, V: 0.061, B:0.082, surplus is Ti and inevitable impurity；
Cast titanium alloy pump housing preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melting, waters Note: smelting temperature: 1813 DEG C, pouring temperature is 1754 DEG C；After the demoulding, the pump housing obtained carries out heat treatment: first entered by the pump housing Row heating, be warming up to 950 DEG C, heating rate 300 DEG C/h, be incubated 6 hours, after be cooled to 650 DEG C, rate of temperature fall 100 DEG C/ Hour, be incubated 7 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 4 hours, after be again cooled to 450 DEG C, Rate of temperature fall 50 DEG C/h, is incubated 9 hours, after be again cooled to 250 DEG C, rate of temperature fall 40 DEG C/h, be incubated 6 hours, after Air cooling to room temperature,
Afterwards pump housing surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of (weight): take 98% dense H2SO443 parts, the HCL of 36.5% 17 parts, propanoic acid 1.3 parts, ethylenediamine 1.4 Part, alkyl imidazoline quaternary ammonium salt 11 parts；11 parts of water；
Passivating solution consists of (weight): polyimides 11 parts, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N- (2-amino-ethyl)-3-amino propyl methyl dimethoxysilane 2.4 parts, Sodium fluoroborate 10.2 parts, 1.3 parts of sulphuric acid, dialkyl group Phosphordithiic acid oxygen molybdenum 6.4 parts, 26 parts of water；
Pump housing outer surface after passivation is coated zirconium oxide series ceramic material；Zirconium oxide is formed by being coated in pump housing outer surface Series ceramic material layer, zirconium oxide series ceramic material layer thickness 0.4mm, zirconium oxide series ceramic material composition of layer includes: zirconium oxide 52 Part, titanium boride 23 parts, titanium carbide 24 parts, silicon oxide 1.4 parts, heats the pump housing after coating, is warming up to 750 DEG C, heat up Speed 250 DEG C/h, is incubated 4 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again drop Temperature to 250 DEG C, rate of temperature fall 75 DEG C/h, be incubated 7 hours, rear air cooling to room temperature,
Afterwards pump housing inner surface is coated titanium carbide series ceramic material；Titanium carbide system is formed by being coated in pump housing inner surface Ceramic material layer, titanium carbide series ceramic material layer thickness 0.5mm, titanium carbide series ceramic material composition of layer includes: titanium carbide 90 Part, titanium nitride 16 parts, chromium carbide 10 parts, titanium oxide 5.4 parts, heats the pump housing after coating, is warming up to 600 DEG C, heat up Speed 200 DEG C/h, is incubated 3 hours, after be cooled to 400 DEG C, rate of temperature fall 100 DEG C/h, be incubated 7 hours, after again drop Warm to 100 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 12 hours, rear air cooling, to room temperature, obtains the final pump housing,
It is characterized in that, cast titanium alloy impeller body chemical composition is Zn:8.3, Al:5.2, Si:3.1, Cu: 2.4, Fe:0.63, Mg:0.51, Ag:0.54, Cr:0.12, Zr:0.054, La:0.033, Ta: 0.032, B:0.024, surplus is Ti and inevitable impurity；
Cast titanium alloy impeller body preparation method: comprise the following steps: according to aforementioned proportion alloyage, alloy material melts Refining, cast: smelting temperature: 1814 DEG C, pouring temperature is 1753 DEG C；After the demoulding, the impeller body obtained carries out heat treatment: first Impeller is heated, is warming up to 850 DEG C, heating rate 300 DEG C/h, be incubated 7 hours, after be cooled to 700 DEG C, cooling speed Rate 100 DEG C/h, is incubated 5 hours, after be warming up to 800 DEG C, heating rate 100 DEG C/h, be incubated 5 hours, after again lower the temperature To 450 DEG C, rate of temperature fall 50 DEG C/h, be incubated 4 hours, after be again cooled to 200 DEG C, rate of temperature fall 40 DEG C/h, be incubated 5 Hour, rear air cooling to room temperature,
Afterwards impeller body surface is carried out pickling and Passivation Treatment, wherein:
Pickle consists of: take 98% dense (H2SO4) 62 parts, (HCL) of 36.5% 3 parts, propanoic acid 6 parts, ethylenediamine 1.3 parts, alkane Base imidazoline quaternary ammonium salt 11.3 parts；11 parts of water；
Passivating solution consists of: polyimides 7-8 part, 2-(3,4-epoxycyclohexyl) ethyl trimethoxy silane 5 parts, N-(2-ammonia Base ethyl)-3-amino propyl methyl dimethoxysilane 9 parts, Sodium fluoroborate 11 parts, 8.3 parts of sulphuric acid, dialkyl dithiophosphoric acid Oxygen molybdenum 21 parts, 27 parts of water；
Impeller body after passivation is coated outer titanium nitride series ceramic material layer；Outer nitrogen is formed by being coated in impeller surface Changing titanium series ceramic material layer, titanium nitride series ceramic material layer thickness 0.5mm, titanium nitride series ceramic material composition of layer includes: nitridation Titanium 68 parts, titanium carbide 29 parts, zirconium oxide 10 parts, silicon oxide 1.8 parts, the impeller after coating is heated, is warming up to 800 DEG C, Heating rate 200 DEG C/h, is incubated 5 hours, after be cooled to 550 DEG C, rate of temperature fall 100 DEG C/h, be incubated 3 hours, after again Secondary it is cooled to 200 DEG C, rate of temperature fall 50 DEG C/h, it is incubated 7 hours, rear air cooling, to room temperature, obtains final impeller.
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