CN106039183A - 一种用于尿频、尿失禁的中药组合物 - Google Patents

一种用于尿频、尿失禁的中药组合物 Download PDF

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CN106039183A
CN106039183A CN201610657487.XA CN201610657487A CN106039183A CN 106039183 A CN106039183 A CN 106039183A CN 201610657487 A CN201610657487 A CN 201610657487A CN 106039183 A CN106039183 A CN 106039183A
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radix
fructus
semen
rhizoma
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姜晓华
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Abstract

本发明涉及一种用于尿频、尿失禁的中药组合物，它是由下列重量配比的原料药物组成的：党参、白术、熟地、山药、山茱萸、补骨脂、益智仁、陈皮、升麻、牡蛎、黄芪、杜仲、覆盆子、金樱子、肉桂、芡实、茯苓、车前子、沉香、当归、沙苑子、菟丝子、甘草、龙骨、萹蓄、白茅根、灯芯草、防己。本发明的中药组合物均采用天然的中草药，具有利水通淋、补益肝肾、健脾益气、清热凉血、补血益精、固精缩尿、活血通经的功效，总有效率达95.35%，治愈率达64.65%。

Description

一种用于尿频、尿失禁的中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医用配制品，具体地说是一种用于尿频、尿失禁的中药组合物。
背景技术
正常成人白天排尿4~6次，夜间0~2次，次数明显增多称尿频。尿失禁是不能由意识控制排尿功能、尿液不自主地流出，尿失禁是排尿障碍性疾患的常见症状，本质上是膀胱贮尿机能障碍的表现，尿失禁并非一个独立的疾病，而是某些疾患累及膀胱、尿道功能的结果。伴随着社会的老龄化，尿频、尿失禁已成为社会问题，特别是尿频和尿失禁限制病人的行动范围，显著降低他们的生活质量，且西药治疗效果不佳，复发比例高，副作用大，给病人带来沉重的负担。
中医认为，肾主水，肾司二阴，主二便，肾与膀胱相表里，膀胱的开合与尿液的排泄有关，而膀胱的开合，依赖于肾的气化，肾的气化正常，则膀胱开合正常，浊液得泄，若肾的气化失常，则影响膀胱的开合，导致膀胱开合不利，而见尿少、水肿等症；或致膀胱约束无权，而见多尿、遗尿等症。肾气的盛衰，直接影响膀胱的气化与开合。夏秋之交，湿热邪盛，侵袭机体，湿热之邪困阻三焦，气机不利，或湿热伤中，中焦不运，升降失司，浊阴不降，下焦不利，湿热内郁，发为此病。淋证日久，过服寒凉，伤中败胃，或劳倦过度，损伤脾土，或膀胱湿热久蕴，内伤于肾，致脾肾气虚，脾不运化，肾失开阖，水道不利，湿浊留恋不去，则淋沥不已，时作时止；湿热久蕴，或渗湿利尿太过，伤及肾阴，肾阴不足，水不涵木，致肝肾阴虚；阴虚而湿热留恋，膀胱气化不利，则小便淋沥不已，或阴虚火旺，虚火灼络，络伤血溢，则血随溺出；淋病治不得法，显证虽去，余邪未尽，停蓄下焦，暗耗气阴，若清利太过，湿热虽去，但正气受伤，或失治，久病不愈，湿热不除，气阴两伤。
发明内容
本发明的目的就是为了克服上述现有的技术不足，根据中医理论，通过数年的药物筛选和反复临床验证，提供一种具有利水通淋、补益肝肾、健脾益气、清热凉血、补血益精、固精缩尿、活血通经的功能，配伍合理，药源广，成本低，疗效显著，无副作用的治疗尿频、尿失禁的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种用于尿频、尿失禁的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：党参10-20g，白术10-20g，熟地10-20g，山药10-30g，山茱萸10-20g，补骨脂10-20g，益智仁10-20g，陈皮5-15g，升麻10-20g，牡蛎20-35g，黄芪20-60g，杜仲10-20g，覆盆子10-20g，金樱子5-15g，肉桂5-10g，芡实10-20g，茯苓10-20g，车前子10-20g，沉香3-8g，当归10-20g，沙苑子10-20g，菟丝子10-20g，甘草20-40g，龙骨15-30g，萹蓄10-20g，白茅根10-30g，灯芯草2-5g，防己5-14g。
本发明的优选技术方案是：一种用于尿频、尿失禁的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：党参15g，白术12g，熟地15g，山药20g，山茱萸12g，补骨脂10g，益智仁10g，陈皮10g，升麻10g，牡蛎30g，黄芪30g，杜仲12g，覆盆子10g，金樱子10g，肉桂6g，芡实15g，茯苓12g，车前子15g，沉香5g，当归10g，沙苑子10g，菟丝子12g，甘草30g，龙骨20g，萹蓄15g，白茅根20g，灯芯草3g，防己9g。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方，其原料成本低，治疗尿频、尿失禁疗效高，无毒副作用。本发明中药组合物中：党参【性味】甘，平【归经】归脾、肺经【功能主治】补中益气，健脾益肺。用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。白术【性味】甘、苦，温【归经】归脾、胃经【功能主治】补脾，益胃，燥湿，和中，安胎，主治脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。熟地【性味】甘，微温【归经】归肝、肾经【功能主治】补血滋润，益精填髓，用于血虚萎黄，眩晕心悸，月经不调，崩不止，肝肾阴亏，潮热盗汗，遗精阳痿，不育不孕，月经不调，崩漏下血，腰膝酸软，耳鸣耳聋，头目昏花，须发早白，消渴，便秘，肾虚喘促。山药【性味】甘，平【归经】归脾、肺、肾经【功能主治】具有健脾补肺、益胃补肾、固肾益精、聪耳明目、助五脏、强筋骨、长志安神、延年益寿的功效。主治脾胃虚弱、倦怠无力、食欲不振、久泄久痢、肺气虚燥、痰喘咳嗽、肾气亏耗、腰膝酸软、下肢痿弱、消渴尿频、遗精早泄、带下白浊、皮肤赤肿、肥胖等病症。山茱萸【性味】酸、涩，微温【归经】归肝、肾经【功能主治】补益肝肾，收敛固涩，固精缩尿，止带止崩，生津止渴，止汗。主治腰膝酸痛，头晕耳鸣，健忘，遗精、滑精，遗尿尿频，崩漏带下、月经不调，大汗虚脱 ，内热消渴。补骨脂【性味】辛、苦，温【归经】归肾、脾经【功能主治】补肾助阳，纳气平喘，温脾止泻。主治肾虚冷泻，遗尿，滑精，小便频数，阳痿，腰膝冷痛，虚寒喘嗽，外用治白癜风。益智仁【性味】辛，温【归经】归脾、肾经【功能主治】温脾暖肾，固气涩精。主治冷气腹痛，中寒吐泻，多唾，遗精，小便余沥，夜多小便。陈皮【性味】温、苦，辛【归经】归脾、肺经【功能主治】理气健脾，燥湿化痰，主治脘腹胀满，食少吐泻，咳嗽痰多。升麻【性味】辛、甘，微寒【归经】归肺、脾、大肠、胃经【功能主治】发表透疹，清热解毒，升阳举陷。主治时气疫疠，头痛寒热，喉痛，口疮，斑疹不透，中气下陷，久泻久痢，脱肛，妇女崩、带，子宫下坠，痈肿疮毒。牡蛎【性味】味咸，性微寒【归经】归肝、胆、肾经【功能主治】有重镇安神、平肝潜阳、收敛固涩作用，可用治心神不安、惊悸失眠、阴虚阳亢、头晕目眩及各种滑脱证。黄芪【性味】甘，温【归经】归肺、脾经【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴，慢性肾炎蛋白尿，糖尿病。杜仲【性味】甘、微辛，温【归经】归肝、肾经【功能主治】补肝肾，强筋骨，安胎。主治腰脊酸疼，阳痿，尿频，小便余沥，风湿痹痛，胎动不安，习惯性流产。覆盆子【性味】甘、酸，温【归经】归肾、膀胱经【功能主治】益肾，固精，缩尿。用于肾虚遗尿，小便频数，阳痿早泄，遗精滑精。金樱子【性味】酸、甘、涩，平【归经】归肾、膀胱、大肠经【功能主治】固精缩尿，固崩止带，涩肠止泻。主治遗精滑精，遗尿尿频，崩漏带下，久泻久痢。肉桂【性味】辛、甘，大热【归经】归心、肝、脾、肾经【功能主治】补火助阳，引火归源，散寒止痛，活血通经。用于阳痿，宫冷，腰膝冷痛，肾虚作喘，阳虚眩晕，目赤咽痛，心腹冷痛，虚寒吐泻，寒疝，奔豚，经闭，痛经。芡实【性味】甘、涩，平【归经】归脾、肾经【功能主治】益肾固精，补脾止泻，祛湿止带。用于梦遗滑精，遗尿尿频，脾虚久泻，白浊，带下。茯苓【性味】甘、淡，平【归经】归心、脾、肾经【功能主治】利水消肿，渗湿，健脾，宁心，主治小便不利，水肿胀满，痰饮咳逆，呕逆，恶阻，泄泻，遗精，淋浊，惊悸，健忘等症。车前子【性味】甘，寒【归经】归肾，肝，肺经【功能主治】利水通淋，利湿止泻，清肝明目，清肺化痰。用于小便不利，水肿，淋证，暑湿泄泻，肝热目赤肺热咳嗽。沉香【性味】辛、苦，温【归经】归脾、胃、肺、肾经【功能主治】降气温中，暖肾纳气。治气逆喘息，呕吐呃逆，脘腹胀痛，腰膝虚冷，大肠虚秘，小便气淋，男子精冷。当归【性味】甘、辛、温【归经】归肝、心、脾经【功能主治】具有补血，活血，调经止痛，润肠通便的功效。主治血虚、血瘀诸症，眩晕头痛，心悸肢麻，月经不调，经闭，痛经，崩漏，结聚，虚寒腹痛，痿痹，赤痢后重，肠燥便难，跌打肿痛，痈疽疮疡。沙苑子【性味】甘，温【归经】归肝、肾经【功能主治】补肝，益肾，明目，固精。治肝肾不足，腰膝酸痛，目昏，遗精早泄，小便频数，遗尿，尿血，白带。菟丝子【性味】辛、甘，平【归经】归肝、脾、肾经，【功能主治】补肾益精，养肝明目，固胎止泄。主治腰膝酸痛，遗精，阳痿早泄，不育，消渴，淋浊，遗尿，目昏耳鸣，胎动不安，流产，泄泻。甘草【性味】甘，平【归经】归心、脾、肺、胃经【功能主治】有补脾益气，润肺止咳，清热解毒，缓解止痛，缓和药性的功效。龙骨【性味】甘涩，平【归经】归心、肝、肾、大肠经【功能主治】镇惊安神，敛汗固精，止血涩肠，生肌敛疮。治惊痫癫狂，怔忡健忘，失眠多梦，自汗盗汗，遗精淋浊，吐衄便血，崩漏带下，泻痢脱肛，溃疡久不收口。萹蓄【性味】苦，微寒【归经】归膀胱经【功能主治】利尿通淋，杀虫，止痒。主治膀胱热淋，小便短赤，淋沥涩痛，皮肤湿疹，阴痒带下。白茅根【性味】甘，寒【归经】归肺、胃、膀胱经【功能主治】凉血止血，清热利尿。用于血热吐血，衄血，尿血，热病烦渴，肺热咳嗽，胃热呕吐，湿热黄疸，水肿尿少，热淋涩痛，急性肾炎水肿。灯芯草【性味】微寒，甘，淡【归经】归心、肺、小肠经【功能主治】有利水通淋，清心除烦的功效。用于小便不利，淋沥涩痛，心热烦躁，小儿夜啼。防己【性味】辛、苦，寒【归经】归肺、膀胱经【功能主治】祛风止痛，利水消肿。主治风湿痹痛，水肿脚气，小便不利，湿疹疮毒。本发明具有利水通淋、补益肝肾、健脾益气、清热凉血、补血益精、固精缩尿、活血通经的功效，对尿频、尿失禁达到标本兼治的目的。
本发明组合物的组分均采用天然的中草药，其配制简便、药源广、成本低。其遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证，其疗效显著，作用可靠，药性平和，未出现毒副作用，总有效率95.35%，治愈率达64.65%。
具体实施方式
实施例1：一种用于尿频、尿失禁的中药组合物，它是由下列重量配比的原料药物组成的：党参10g，白术10g，熟地10g，山药30g，山茱萸10g，补骨脂10g，益智仁10g，陈皮15g，升麻10g，牡蛎20g，黄芪60g，杜仲20g，覆盆子10g，金樱子12g，肉桂5g，芡实14g，茯苓12g，车前子20g，沉香3g，当归10g，沙苑子10g，菟丝子10g，甘草40g，龙骨18g，萹蓄20g，白茅根18g，灯芯草5g，防己13g。
实施例2：一种用于尿频、尿失禁的中药组合物，它是由下列重量配比的原料药物组成的：党参16g，白术20g，熟地16g，山药10g，山茱萸16g，补骨脂12g，益智仁12g，陈皮13g，升麻12g，牡蛎22g，黄芪50g，杜仲14g，覆盆子16g，金樱子5g，肉桂7g，芡实16g，茯苓10g，车前子16g，沉香4g，当归14g，沙苑子14g，菟丝子14g，甘草35g，龙骨15g，萹蓄10g，白茅根30g，灯芯草4g，防己14g。
实施例3：一种用于尿频、尿失禁的中药组合物，它是由下列重量配比的原料药物组成的：党参18g，白术14g，熟地12g，山药15g，山茱萸14g，补骨脂14g，益智仁14g，陈皮11g，升麻14g，牡蛎35g，黄芪40g，杜仲16g，覆盆子12g，金樱子8g，肉桂8g，芡实10g，茯苓20g，车前子10g，沉香5g，当归20g，沙苑子20g，菟丝子20g，甘草32g，龙骨24g，萹蓄14g，白茅根10g，灯芯草3g，防己10g。
实施例4：一种用于尿频、尿失禁的中药组合物，它是由下列重量配比的原料药物组成的：党参20g，白术16g，熟地20g，山药25g，山茱萸12g，补骨脂16g，益智仁16g，陈皮5g，升麻16g，牡蛎33g，黄芪30g，杜仲12g，覆盆子14g，金樱子15g，肉桂9g，芡实18g，茯苓16g，车前子12g，沉香6g，当归16g，沙苑子16g，菟丝子16g，甘草25g，龙骨28g，萹蓄18g，白茅根15g，灯芯草2g，防己5g。
实施例5：一种用于尿频、尿失禁的中药组合物，它是由下列重量配比的原料药物组成的：党参17g，白术18g，熟地18g，山药28g，山茱萸18g，补骨脂18g，益智仁18g，陈皮8g，升麻18g，牡蛎30g，黄芪20g，杜仲18g，覆盆子18g，金樱子13g，肉桂10g，芡实20g，茯苓18g，车前子18g，沉香8g，当归18g，沙苑子18g，菟丝子18g，甘草20g，龙骨30g，萹蓄12g，白茅根25g，灯芯草5g，防己6g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：取本发明组方的原料药物药物放入容器中，先加水浸泡，加冷水漫过药面，浸泡20～30分钟，再加水没过药面约15厘米，进行第一次煎煮，先用武火煎煮，煮沸后用文火煎煮35～40分钟，滤出取药液汁200ml；第二煎煮，加水没过药面约12厘米，水沸后煎煮30～35分钟，滤出取药液汁200ml。两次煎煮取得药液汁合并。
一种用于尿频、尿失禁的中药组合物，临床疗效总结：
一、一般性资料：
本中药组合物应用于临床观察病72例，其中男36例，女36例，年龄26～65岁。病程最短者3个月，最长者达4年。
二、用法用量：
临床应用时，组合物中的组分、用量根据患者的体重、年龄及症状酌情增减。10剂为一疗程，一天一剂，水煎两遍取汁约400ml，分早、晚两次饭前半小时温热服用。
三、疗效标准：
完全缓解：临床症状完全消失。
部分缓解：临床症状改善。
无效：临床症状无变化或加重。
四、治疗效果：临床观察病例中，服药1-5个疗程，治愈46例，有效22例，无效4例。治疗期间未发生毒副作用。
六、典型病例：
1、高某，男，60岁，右侧肢体麻木，第二天右侧肢体活动不便，医院检查，诊断为左基底节脑梗塞，入院治疗，半个月后右侧肢体仍感无力，腰痛酸软，小便失禁，经常尿裤子，使用导尿器定时开放，一周后全身发烧，控制感染后，尿失禁更加严重，尤其是晚上，被子、褥子都被尿湿，后服用本发明的中药组合物制备的药剂4个疗程，患者临床症状消失，排尿正常。
2、张某，男，55岁，患者“慢性前列腺炎”多年。尿频，尿细，有抽痛，夜尿4-5次，晚上起夜后身热、汗出，口干，腰酸膝软，双下肢乏力，下肢及腰部发凉，后服用本发明的中药组合物制备的药剂3个疗程，尿频、抽痛等症状明显好转，起夜减少至1-2次。
3、李某，女，33岁，两年无明显诱因尿频，尿急，每15-40分钟上厕所一次，夜间睡眠时多尿床。后来症状加重，尿频、尿急难忍，时有尿失禁，夜间多尿床，困倦不敢睡，精神恍惚，无法正常工作。后服用本发明的中药组合物制备的药剂2个疗程，尿频症状明显好转，一天去7-8次厕所，晚上2-3次，继续服药2个疗程，排尿量和次数恢复正常。

Claims (2)

1.一种用于尿频、尿失禁的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：党参10-20g，白术10-20g，熟地10-20g，山药10-30g，山茱萸10-20g，补骨脂10-20g，益智仁10-20g，陈皮5-15g，升麻10-20g，牡蛎20-35g，黄芪20-60g，杜仲10-20g，覆盆子10-20g，金樱子5-15g，肉桂5-10g，芡实10-20g，茯苓10-20g，车前子10-20g，沉香3-8g，当归10-20g，沙苑子10-20g，菟丝子10-20g，甘草20-40g，龙骨15-30g，萹蓄10-20g，白茅根10-30g，灯芯草2-5g，防己5-14g。
2.根据权利要求1所述的一种用于尿频、尿失禁的中药组合物，其特征在于它是由下列重量配比的原料药物组成的：党参15g，白术12g，熟地15g，山药20g，山茱萸12g，补骨脂10g，益智仁10g，陈皮10g，升麻10g，牡蛎30g，黄芪30g，杜仲12g，覆盆子10g，金樱子10g，肉桂6g，芡实15g，茯苓12g，车前子15g，沉香5g，当归10g，沙苑子10g，菟丝子12g，甘草30g，龙骨20g，萹蓄15g，白茅根20g，灯芯草3g，防己9g。
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CN117180382A (zh) * 2023-11-08 2023-12-08 首都医科大学宣武医院 一种治疗尿失禁的中药组合物、制备方法及应用
CN117180382B (zh) * 2023-11-08 2024-02-06 首都医科大学宣武医院 一种治疗尿失禁的中药组合物、制备方法及应用

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