CN106038927A - Plaster for cold of children - Google Patents

Plaster for cold of children Download PDF

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Publication number
CN106038927A
CN106038927A CN201610385957.1A CN201610385957A CN106038927A CN 106038927 A CN106038927 A CN 106038927A CN 201610385957 A CN201610385957 A CN 201610385957A CN 106038927 A CN106038927 A CN 106038927A
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time
extraction
extractum
parts
plaster
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陈瑞
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K9/00—Medicinal preparations characterised by special physical form
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Abstract

The invention relates to an external application unguent, in particular to a plaster for a cold of children. The plaster is prepared from, by weight, 140-160 parts of hollyhock flowers, 30-50 parts of roots of hemerocallis fulva, 80-100 parts of leaves of Japanese banana, 30-50 parts of rhizomes of clerodendrum bungei, 10-15 parts of folium sennae, 80-100 parts of flos trollii, 18-20 parts of safflower seed oil, 6-8 parts of activated clay, 2-3 parts of taurine and 1-2 parts of aminophylline, wherein concentrated extract solutions of hollyhock flowers, roots of hemerocallis fulva, leaves of Japanese banana, rhizomes of clerodendrum bungei, folium sennae and flos trollii are taken for use. The plaster for a cold of children directly acts to an affected part, the permeability of effective ingredients is high, and the plaster has the effects of relieving exterior syndromes, removing cold-evil, discharging damp and clearing away internal heat, and especially has a strong killing effect on rhinoviruses, influenza viruses and respiratory syncytial viruses; the plaster is low in raw material cost, convenient and safe to use, remarkable in treatment effect and free of irritation and toxic or side effects on children, and clinical experiments show that the effect on the cold of children can be achieved when the plaster is smeared to children four continuous times in general.

Description

A kind of children's cold plaster
Technical field
The present invention relates to a kind of external application medical ointment, be specifically related to a kind of children's cold plaster.
Background technology
Flu is a kind of slight upper respiratory tract (nose and throat) viral infection, and extra symptom includes heating, ague And muscular soreness, systemic symptoms is more apparent, and the flu of children's cold and adult is different, and it is mainly due to children's torso Resistance is the most weak, and the probability infecting virus is the highest for adult, and treatment simultaneously can not use adult's above Medicine, because the ability to bear of children's torso is more weak, it should select gentleness, neutral medicine to treat, but due to youngster Virgin mostly all the repulsion drinks medicine, adds somewhat to treat difficulty.
Summary of the invention
It is an object of the invention to provide that a kind of cost is relatively low, easy to use, curative effect children's cold plaster faster.
The technical solution used in the present invention is, a kind of children's cold plaster, this plaster is by the raw material of following parts by weight Make,
Flos althaeae roseae 140-160 part, Hemerocallis fulva L. 30-50 part, Folium Musae 80-100 part, Caulis et folium clerodendri bungei 30-50 part, Folium Sennae 10-15 part, gold Flos Nelumbinis 80-100 part, safflower oil 18-20 part, active hargil 6-8 part, taurine 2-3 part, aminophylline 1-2 part.
During making,
Folium Musae being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 320-for the first time 350W, extraction time is 80s, and second time extraction power is 250-260W, and extraction time is 60s, extraction for the first time and second time Extraction time interval 60-80s, takes extract, filters, and it is the extractum of 1.21-1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Garfields Tea being broken to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 380-for the first time 400W, extraction time is 100s, and second time extraction power is 300-320W, and extraction time is 50s, extraction for the first time and second time Extraction time interval 60-80s, takes extract, filters, and it is the extractum of 1.18-1.2 that filtrate is concentrated into the relative density when 65 DEG C；
Flos althaeae roseae being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 420-430W for the first time, Extraction time is 100s, and second time extraction power is 320-350W, and extraction time is 50s, extraction for the first time and second time extraction Time interval 60-65s, takes extract, filters, and it is the extractum of 1.22-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
Hemerocallis fulva L. being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-385W for the first time, extraction The time of taking is 80s, and second time extraction power is 320-330W, and extraction time is 50s, extraction for the first time and second time extraction time Interval 60-70s, takes extract, filters, and it is the extractum of 1.23-1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Caulis et folium clerodendri bungei being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-400W for the first time, Extraction time is 60s, and second time extraction power is 230-250W, and extraction time is 30s, when extraction for the first time and second time extraction Between be spaced 130-145s, take extract, filter, it is the extractum of 1.22-1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Flos Trollii being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 345-350W for the first time, Extraction time is 75s, and second time extraction power is 260-280W, and extraction time is 50s, when extraction for the first time and second time extraction Between be spaced 65-70s, take extract, filter, it is the extractum of 1.21-1.22 that filtrate is concentrated into the relative density when 65 DEG C；
By safflower oil and Flos althaeae roseae extractum, Hemerocallis fulva L. extractum, Folium Musae extractum, Caulis et folium clerodendri bungei extractum, Black Draught, Flos Trollii leaching Cream, active hargil, taurine, aminophylline mixing and stirring, obtain children's cold plaster.
Children's cold plaster with plaster in use, is coated at infant breastbone, after 20-30 minute by this children's cold Wiping with hot towel, if any nasal obstruction, rhinorrhea symptom, available cotton swab dips this plaster wiping nasal cavity.
Children's cold plaster of the present invention directly acts on affected part, and effective ingredient permeability is strong, has and induces sweat, drives away and tremble with fear Heresy, excretion dampness, the effect of removing interior-heat, especially kill more by force effect to rhinovirus, influenza virus, respiratory syncytial virus, This plaster low raw-material cost, easy to use, evident in efficacy, through clinical trial certificate, smear four times the most continuously and just can play Children's cold effect, uses safety, the non-stimulated and toxic and side effects to child.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described:
Embodiment 1, a kind of children's cold plaster, this plaster is made up of the raw material of following parts by weight,
Flos althaeae roseae 140 parts, Hemerocallis fulva L. 30 parts, Folium Musae 80 parts, Caulis et folium clerodendri bungei 30 parts, Folium Sennae 10 parts, Flos Trollii 80 parts, safflower oil 18 parts, active hargil 6 parts, taurine 2 parts, aminophylline 1 part.
During making,
Folium Musae being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8 times, extraction power is 320W for the first time, extraction Time is 80s, and second time extraction power is 250W, and extraction time is 60s, extraction for the first time and second time extraction time interval 60s, takes extract, filters, and it is the extractum of 1.21 that filtrate is concentrated into the relative density when 65 DEG C；
Garfields Tea being broken to 80 mesh, adds the ethanol microwave extracting of its weight 8 times, extraction power is 380W for the first time, extraction Time is 100s, and second time extraction power is 300W, and extraction time is 50s, extraction for the first time and second time extraction time interval 60s, takes extract, filters, and it is the extractum of 1.18 that filtrate is concentrated into the relative density when 65 DEG C；
Flos althaeae roseae being crushed to 80 mesh, adds the water microwave extracting of its weight 6 times, extraction power is 420W for the first time, during extraction Between be 100s, second time extraction power is 320W, and extraction time is 50s, and for the first time extraction is spaced with second time extraction time 60s, takes extract, filters, and it is the extractum of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Hemerocallis fulva L. being crushed to 80 mesh, adds the water microwave extracting of its weight 6 times, extraction power is 380W for the first time, extraction time For 80s, second time extraction power is 320W, and extraction time is 50s, extraction for the first time and second time extraction time interval 60s, takes Extract, filters, and it is the extractum of 1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Caulis et folium clerodendri bungei being crushed to 80 mesh, adds the water microwave extracting of its weight 6 times, extraction power is 380W for the first time, during extraction Between be 60s, second time extraction power is 230W, and extraction time is 30s, and for the first time extraction is spaced with second time extraction time 130s, takes extract, filters, and it is the extractum of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Flos Trollii being crushed to 80 mesh, adds the water microwave extracting of its weight 6 times, extraction power is 345W for the first time, during extraction Between be 75s, second time extraction power is 260W, and extraction time is 50s, and for the first time extraction is spaced 65s with second time extraction time, Taking extract, filter, it is the extractum of 1.21 that filtrate is concentrated into the relative density when 65 DEG C；
By safflower oil and Flos althaeae roseae extractum, Hemerocallis fulva L. extractum, Folium Musae extractum, Caulis et folium clerodendri bungei extractum, Black Draught, Flos Trollii leaching Cream, active hargil, taurine, aminophylline mixing and stirring, obtain children's cold plaster.
Embodiment 2, a kind of children's cold plaster, this plaster is made up of the raw material of following parts by weight,
Flos althaeae roseae 160 parts, Hemerocallis fulva L. 50 parts, Folium Musae 100 parts, Caulis et folium clerodendri bungei 50 parts, Folium Sennae 15 parts, Flos Trollii 100 parts, Semen Flos Carthami Oil 20 parts, active hargil 8 parts, taurine 3 parts, aminophylline 2 parts.
During making,
Folium Musae being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 10 times, extraction power is 350W for the first time, extraction Time is 80s, and second time extraction power is 260W, and extraction time is 60s, extraction for the first time and second time extraction time interval 80s, takes extract, filters, and it is the extractum of 1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Garfields Tea being broken to 80 mesh, adds the ethanol microwave extracting of its weight 10 times, extraction power is 400W for the first time, extraction Time is 100s, and second time extraction power is 320W, and extraction time is 50s, extraction for the first time and second time extraction time interval 80s, takes extract, filters, and it is the extractum of 1.2 that filtrate is concentrated into the relative density when 65 DEG C；
Flos althaeae roseae being crushed to 80 mesh, adds the water microwave extracting of its weight 8 times, extraction power is 430W for the first time, during extraction Between be 100s, second time extraction power is 350W, and extraction time is 50s, and for the first time extraction is spaced with second time extraction time 65s, takes extract, filters, and it is the extractum of 1.25 that filtrate is concentrated into the relative density when 65 DEG C；
Hemerocallis fulva L. being crushed to 80 mesh, adds the water microwave extracting of its weight 8 times, extraction power is 385W for the first time, extraction time For 80s, second time extraction power is 330W, and extraction time is 50s, extraction for the first time and second time extraction time interval 70s, takes Extract, filters, and it is the extractum of 1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Caulis et folium clerodendri bungei being crushed to 80 mesh, adds the water microwave extracting of its weight 8 times, extraction power is 400W for the first time, during extraction Between be 60s, second time extraction power is 250W, and extraction time is 30s, and for the first time extraction is spaced with second time extraction time 145s, takes extract, filters, and it is the extractum of 1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Flos Trollii being crushed to 80 mesh, adds the water microwave extracting of its weight 8 times, extraction power is 350W for the first time, during extraction Between be 75s, second time extraction power is 280W, and extraction time is 50s, and for the first time extraction is spaced 70s with second time extraction time, Taking extract, filter, it is the extractum of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
By safflower oil and Flos althaeae roseae extractum, Hemerocallis fulva L. extractum, Folium Musae extractum, Caulis et folium clerodendri bungei extractum, Black Draught, Flos Trollii leaching Cream, active hargil, taurine, aminophylline mixing and stirring, obtain children's cold plaster.
Embodiment 3, a kind of children's cold plaster, this plaster is made up of the raw material of following parts by weight,
Flos althaeae roseae 150 parts, Hemerocallis fulva L. 40 parts, Folium Musae 900 parts, Caulis et folium clerodendri bungei 40 parts, Folium Sennae 12 parts, Flos Trollii 90 parts, Semen Flos Carthami Oil 19 parts, active hargil 7 parts, taurine 2.5 parts, aminophylline 1.5 parts.
During making,
Folium Musae being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 9 times, extraction power is 330W for the first time, extraction Time is 80s, and second time extraction power is 255W, and extraction time is 60s, extraction for the first time and second time extraction time interval 70s, takes extract, filters, and it is the extractum of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Garfields Tea being broken to 80 mesh, adds the ethanol microwave extracting of its weight 9 times, extraction power is 390W for the first time, extraction Time is 100s, and second time extraction power is 310W, and extraction time is 50s, extraction for the first time and second time extraction time interval 70s, takes extract, filters, and it is the extractum of 1.19 that filtrate is concentrated into the relative density when 65 DEG C；
Flos althaeae roseae being crushed to 80 mesh, adds the water microwave extracting of its weight 7 times, extraction power is 425W for the first time, during extraction Between be 100s, second time extraction power is 330W, and extraction time is 50s, and for the first time extraction is spaced with second time extraction time 62s, takes extract, filters, and it is the extractum of 1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Hemerocallis fulva L. being crushed to 80 mesh, adds the water microwave extracting of its weight 7 times, extraction power is 382W for the first time, extraction time For 80s, second time extraction power is 325W, and extraction time is 50s, extraction for the first time and second time extraction time interval 65s, takes Extract, filters, and it is the extractum of 1.235 that filtrate is concentrated into the relative density when 65 DEG C；
Caulis et folium clerodendri bungei being crushed to 80 mesh, adds the water microwave extracting of its weight 7 times, extraction power is 390W for the first time, during extraction Between be 60s, second time extraction power is 240W, and extraction time is 30s, and for the first time extraction is spaced with second time extraction time 140s, takes extract, filters, and it is the extractum of 1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Flos Trollii being crushed to 80 mesh, adds the water microwave extracting of its weight 7 times, extraction power is 348W for the first time, during extraction Between be 75s, second time extraction power is 270W, and extraction time is 50s, and for the first time extraction is spaced 68s with second time extraction time, Taking extract, filter, it is the extractum of 1.215 that filtrate is concentrated into the relative density when 65 DEG C；
By safflower oil and Flos althaeae roseae extractum, Hemerocallis fulva L. extractum, Folium Musae extractum, Caulis et folium clerodendri bungei extractum, Black Draught, Flos Trollii leaching Cream, active hargil, taurine, aminophylline mixing and stirring, obtain children's cold plaster.
Choose health, the rat 80 of close 15 ages in days of body weight, respectively with l/ influenza virus collunarium inoculation DABAI of 30 μ Mus, l/ rhinovirus collunarium inoculation rat of 25 μ, l/ respiratory syncytial virus collunarium inoculation rat of 20 μ, after 1 day, will be big White mouse is randomly divided into A, B, C, D tetra-groups, often group 20, and A group clear water is applied at rat breastbone；B group is used with child of the present invention Plaster for cold is applied at rat breastbone；C group herbs ' water-decoctum is applied at rat breastbone, the following weight of this herbs ' water-decoctum The raw material of number is made, Flos althaeae roseae 140-160 part, Hemerocallis fulva L. 30-50 part, Folium Musae 80-100 part, Caulis et folium clerodendri bungei 30-50 part, Senna fruit Leaf 10-15 part, Flos Trollii 80-100 part, this herbs ' water-decoctum is when making, by Fructus Cnidii, wild oat, Radix Habenariae Dentatae, Herba Schizonepetae, soil Melon root adds 60-80 times of soak by water 30 minutes；D group is with being applied at rat breastbone with Chinese medical concrete liquid, heavy below this Chinese medical concrete Amount number raw material make, Flos althaeae roseae 140-160 part, Hemerocallis fulva L. 30-50 part, Folium Musae 80-100 part, Caulis et folium clerodendri bungei 30-50 part, kind Rushing down leaf 10-15 part, Flos Trollii 80-100 part, this Chinese medical concrete manufacture method is identical with B group.
After tri-groups of rat process of A, B, C, D terminate, it be observed that two groups of rats of A, C have sneeze, nose of scratching, dyspneic disease Shape, D group rat is even sneeze symptom, breathes slightly difficulty, and B group, without above-mentioned symptom, is observed and all put to death by three groups of rats after terminating, The aseptic lungs that take make lung homogeneous slurry (by lung is heavy and normal saline is placed in refiner homogenate by the weight ratio of 1:9, after homogenate It is placed in test tube at 4 DEG C centrifugal, takes supernatant and be lung homogeneous slurry), take rat blood and prepare serum according to a conventional method, adopt With IL-2 and TNF-α content in double-antibody sandwich Enzyme immunoassay method experiments of measuring rat blood serum, and cytokine in lung IL-2 and TNF-α content.
As a result, in B group rat blood serum, IL-2 content is apparently higher than A, C two groups (P ＜ 0.01), higher than D group (P ＜ 0.05)；B In group rat blood serum, TNF-α content is significantly lower than A, C two groups (P ＜ 0.01), less than D group (P ＜ 0.05)；
In B group induced lung, cytokine IL-2 content is apparently higher than A, C two groups (P ＜ 0.01), higher than D group (P ＜ 0.05)；B group In induced lung, cytokine TNF-alpha content is significantly lower than A, C two groups (P ＜ 0.01), less than D group (P ＜ 0.05).

Claims (2)

1. a children's cold plaster, it is characterised in that this plaster is made up of the raw material of following parts by weight,
Flos althaeae roseae 140-160 part, Hemerocallis fulva L. 30-50 part, Folium Musae 80-100 part, Caulis et folium clerodendri bungei 30-50 part, Folium Sennae 10-15 part, gold Flos Nelumbinis 80-100 part, safflower oil 18-20 part, active hargil 6-8 part, taurine 2-3 part, aminophylline 1-2 part.
A kind of children's cold plaster the most according to claim 1, it is characterised in that this children's cold plaster makes step Rapid as follows:
Folium Musae being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 320-for the first time 350W, extraction time is 80s, and second time extraction power is 250-260W, and extraction time is 60s, extraction for the first time and second time Extraction time interval 60-80s, takes extract, filters, and it is the extractum of 1.21-1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Garfields Tea being broken to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 380-for the first time 400W, extraction time is 100s, and second time extraction power is 300-320W, and extraction time is 50s, extraction for the first time and second time Extraction time interval 60-80s, takes extract, filters, and it is the extractum of 1.18-1.2 that filtrate is concentrated into the relative density when 65 DEG C；
Flos althaeae roseae being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 420-430W for the first time, Extraction time is 100s, and second time extraction power is 320-350W, and extraction time is 50s, extraction for the first time and second time extraction Time interval 60-65s, takes extract, filters, and it is the extractum of 1.22-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
Hemerocallis fulva L. being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-385W for the first time, extraction The time of taking is 80s, and second time extraction power is 320-330W, and extraction time is 50s, extraction for the first time and second time extraction time Interval 60-70s, takes extract, filters, and it is the extractum of 1.23-1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Caulis et folium clerodendri bungei being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-400W for the first time, Extraction time is 60s, and second time extraction power is 230-250W, and extraction time is 30s, when extraction for the first time and second time extraction Between be spaced 130-145s, take extract, filter, it is the extractum of 1.22-1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Flos Trollii being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 345-350W for the first time, Extraction time is 75s, and second time extraction power is 260-280W, and extraction time is 50s, when extraction for the first time and second time extraction Between be spaced 65-70s, take extract, filter, it is the extractum of 1.21-1.22 that filtrate is concentrated into the relative density when 65 DEG C；
By hemp seed oil and Flos althaeae roseae extractum, Hemerocallis fulva L. extractum, Folium Musae extractum, Caulis et folium clerodendri bungei extractum, Black Draught, Flos Trollii leaching Cream, safflower oil extractum, active hargil extractum, taurine extractum, aminophylline extractum mixing and stirring, obtain children's cold and use Plaster.
CN201610385957.1A 2016-06-03 2016-06-03 Plaster for cold of children Pending CN106038927A (en)

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CN108619465A (en) * 2017-03-22 2018-10-09 赖彦君 It is a kind of specially to control Chinese medicine patch of baby cold and preparation method thereof

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Application publication date: 20161026