CN106038946A - Plaster special for child virus diarrhea - Google Patents
Plaster special for child virus diarrhea Download PDFInfo
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- CN106038946A CN106038946A CN201610385965.6A CN201610385965A CN106038946A CN 106038946 A CN106038946 A CN 106038946A CN 201610385965 A CN201610385965 A CN 201610385965A CN 106038946 A CN106038946 A CN 106038946A
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- 239000011505 plaster Substances 0.000 title claims abstract description 31
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 18
- 241000700605 Viruses Species 0.000 title claims abstract description 18
- 239000000284 extract Substances 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 240000009206 Hemerocallis fulva Species 0.000 claims abstract 4
- 235000002941 Hemerocallis fulva Nutrition 0.000 claims abstract 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract 4
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960003556 aminophylline Drugs 0.000 claims abstract 2
- 239000003813 safflower oil Substances 0.000 claims abstract 2
- 229960003080 taurine Drugs 0.000 claims abstract 2
- 238000000605 extraction Methods 0.000 claims description 133
- 239000000706 filtrate Substances 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 18
- 235000011201 Ginkgo Nutrition 0.000 claims description 16
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 16
- 244000134336 Malus baccata Species 0.000 claims description 16
- 235000005079 Malus baccata Nutrition 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 9
- 239000000395 magnesium oxide Substances 0.000 claims description 9
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 9
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 9
- 239000011726 vitamin B6 Substances 0.000 claims description 9
- 235000019158 vitamin B6 Nutrition 0.000 claims description 9
- 229940011671 vitamin b6 Drugs 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims 4
- 239000006071 cream Substances 0.000 claims 2
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- 235000019485 Safflower oil Nutrition 0.000 claims 1
- 229940057193 black draught Drugs 0.000 claims 1
- 239000010460 hemp oil Substances 0.000 claims 1
- 238000002386 leaching Methods 0.000 claims 1
- 235000005713 safflower oil Nutrition 0.000 claims 1
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 239000004615 ingredient Substances 0.000 abstract description 2
- 230000002147 killing effect Effects 0.000 abstract description 2
- 230000035699 permeability Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 240000000530 Alcea rosea Species 0.000 abstract 2
- 235000017334 Alcea rosea Nutrition 0.000 abstract 2
- 235000017303 Althaea rosea Nutrition 0.000 abstract 2
- 241000530075 Clerodendrum bungei Species 0.000 abstract 2
- 240000000569 Musa basjoo Species 0.000 abstract 2
- 235000000139 Musa basjoo Nutrition 0.000 abstract 2
- 241001530121 Trollius Species 0.000 abstract 2
- 241000709661 Enterovirus Species 0.000 abstract 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 1
- 239000004927 clay Substances 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 241000218628 Ginkgo Species 0.000 description 15
- 241000700159 Rattus Species 0.000 description 8
- 230000000968 intestinal effect Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- -1 Gu Wei Element Chemical compound 0.000 description 4
- 235000008216 herbs Nutrition 0.000 description 4
- 210000001562 sternum Anatomy 0.000 description 4
- 210000001198 duodenum Anatomy 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 241000252983 Caecum Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 210000004534 cecum Anatomy 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000019637 Infantile Diarrhea Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000025507 digestive system development Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to an externally applied plaster, in particular to a plaster special for child virus diarrhea. The plaster is prepared from, by weight, 140-160 parts of flowers of hollyhock, 30-50 parts of roots of hemerocallis fulva L., 80-100 parts of leaves of Japanese bananas, 30-50 parts of stems and leaves of rose glorybower, 10-15 parts of folium sennae, 80-100 parts of Chinese globeflower flowers, 18-20 parts of safflower seed oil, 6-8 parts of activated clay, 2-3 parts of taurine and 1-2 parts of aminophylline, and flowers of hollyhock, roots of hemerocallis fulva L., leaves of Japanese bananas, stems and leaves of rose glorybower, folium sennae and Chinese globeflower flowers are extracted to obtain concentrated extracts for use; the plaster for treating colds in children directly act on the affected part, the permeability of effectively ingredients is high, the effects of relieving an exterior syndrome, removing cold-evil, draining moisture and clearing inner heat are achieved, a high killing effect on rhinovirus, influenza viruses, respiratory syncytial viruses is particularly achieved, and the plaster is low in raw material cost, convenient to use and significant in curative effect; it is proved through clinical tests that the effect on treating the colds in children can be achieved by conducting smearing continuously four times, use is safe, and neither irritation nor toxic and side effects on the children exist.
Description
Technical field
The present invention relates to a kind of external application medical ointment, be specifically related to a kind of special plaster of child virus diarrhea.
Background technology
Infantile diarrhea is the common frdquently encountered disease being only second to respiratory tract infection in department of pediatrics, especially important with child virus diarrhea,
Not only number of the infected is numerous, and the vaccine that there is no at present, again without medicine special, effective, it mainly due to
Child's digestive system development is immature, body defenses function is poor, and the probability infecting virus is the highest for adult, with
Time treatment can not use above the medicine of adult, because the ability to bear of children's torso is more weak, it should select gentle, in
Property medicine treat, but the most all repel due to child and drink medicine, adds somewhat to treat difficulty.
Summary of the invention
It is an object of the invention to provide that a kind of cost is relatively low, easy to use, curative effect children's cold plaster faster.
The technical solution used in the present invention is, a kind of special plaster of child virus diarrhea, this plaster is by following weight portion
The raw material of number is made,
Radix Folium Allii tuberosi 115-120 part, Malus baccata (Linn.) Borkh. 20-30 part, Folium Clerodendri Trichotomi 70-80 part, Folium Ginkgo 20-30 part, Oleum sesami 15-18
Part, medical grade magnesium oxide 3-5 part, oryzanol 2-2.5 part, vitamin B6 2-3 part.
During making,
Radix Folium Allii tuberosi being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 420-for the first time
430W, extraction time is 80s, and second time extraction power is 380-385W, and extraction time is 100s, extraction for the first time and second time
Extraction time interval 50-55s, takes extract, filters, and it is the extractum of 1.22-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
Malus baccata (Linn.) Borkh. being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 450-for the first time
480W, extraction time is 60s, and second time extraction power is 400-420W, and extraction time is 30s, extraction for the first time and second time
Extraction time interval 60-70s, takes extract, filters, and it is the extractum of 1.2-1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Clerodendri Trichotomi being broken to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-400W for the first time,
Extraction time is 120s, and second time extraction power is 320-330W, and extraction time is 80s, extraction for the first time and second time extraction
Time interval 60-70s, takes extract, filters, and it is the extractum of 1.16-1.18 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Ginkgo being broken to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-400W for the first time, extraction
The time of taking is 90s, and second time extraction power is 340-350W, and extraction time is 70s, extraction for the first time and second time extraction time
Interval 60-70s, takes extract, filters, and it is the extractum of 1.23-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
By Oleum sesami and Radix Folium Allii tuberosi extractum, Malus baccata (Linn.) Borkh. extractum, Folium Clerodendri Trichotomi extractum, Folium Ginkgo extractum, medical grade magnesium oxide, Gu Wei
Element, vitamin B6 mixing and stirring, obtain the special plaster of child virus diarrhea.
Children's cold plaster with plaster in use, is coated on infant abdominal part by this children's cold, uses after 20-30 minute
Hot towel is wiped.
The special plaster of child virus diarrhea of the present invention directly acts on affected part, and effective ingredient permeability is strong, takes turns in digestive tract
Shape virus has an effect of killing more by force, and can improve content and the activity of intestinal mucosa Lactose enzyme, this plaster low raw-material cost, makes
With convenient, evident in efficacy, through clinical trial certificate, stick four times the most continuously and just can play antidiarrheal efficacy, use safety, to youngster
Virgin non-stimulated and toxic and side effects.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be described:
Embodiment 1, a kind of special plaster of child virus diarrhea, this plaster is made up of the raw material of following parts by weight,
Radix Folium Allii tuberosi 115 parts, Malus baccata (Linn.) Borkh. 20 parts, Folium Clerodendri Trichotomi 70 parts, Folium Ginkgo 20 parts, Oleum sesami 15 parts, medical grade magnesium oxide 3
Part, oryzanol 2 parts, vitamin B6 2 parts.
During making,
Radix Folium Allii tuberosi being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8 times, extraction power is 420W for the first time, extraction
Time is 80s, and second time extraction power is 380W, and extraction time is 100s, extraction for the first time and second time extraction time interval
50s, takes extract, filters, and it is the extractum of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Malus baccata (Linn.) Borkh. being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8 times, extraction power is 450W for the first time, extraction
Time is 60s, and second time extraction power is 400W, and extraction time is 30s, extraction for the first time and second time extraction time interval
60s, takes extract, filters, and it is the extractum of 1.2 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Clerodendri Trichotomi being broken to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380W for the first time, extraction
Time is 120s, and second time extraction power is 320W, and extraction time is 80s, extraction for the first time and second time extraction time interval
60s, takes extract, filters, and it is the extractum of 1.16 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Ginkgo being broken to 80 mesh, adds the water microwave extracting of its weight 6 times, extraction power is 380 for the first time, and extraction time is
90s, second time extraction power is 340W, and extraction time is 70s, extraction for the first time and second time extraction time interval 60s, takes extraction
Taking liquid, filter, it is the extractum of 1.23 that filtrate is concentrated into the relative density when 65 DEG C；
By Oleum sesami and Radix Folium Allii tuberosi extractum, Malus baccata (Linn.) Borkh. extractum, Folium Clerodendri Trichotomi extractum, Folium Ginkgo extractum, medical grade magnesium oxide, Gu Wei
Element, vitamin B6 mixing and stirring, obtain the special plaster of child virus diarrhea.
Embodiment 2, a kind of special plaster of child virus diarrhea, this plaster is made up of the raw material of following parts by weight,
Radix Folium Allii tuberosi 120 parts, Malus baccata (Linn.) Borkh. 30 parts, Folium Clerodendri Trichotomi 80 parts, Folium Ginkgo 30 parts, Oleum sesami 18 parts, medical grade magnesium oxide 5
Part, oryzanol 2.5 parts, vitamin B6 3 parts.
During making,
Radix Folium Allii tuberosi being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 10 times, extraction power is 430W for the first time, extraction
Time is 80s, and second time extraction power is 385W, and extraction time is 100s, extraction for the first time and second time extraction time interval
55s, takes extract, filters, and it is the extractum of 1.25 that filtrate is concentrated into the relative density when 65 DEG C；
Malus baccata (Linn.) Borkh. being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 10 times, extraction power is 480W for the first time, extraction
Time is 60s, and second time extraction power is 420W, and extraction time is 30s, extraction for the first time and second time extraction time interval
70s, takes extract, filters, and it is the extractum of 1.22 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Clerodendri Trichotomi being broken to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 400W for the first time, extraction
Time is 120s, and second time extraction power is 330W, and extraction time is 80s, extraction for the first time and second time extraction time interval
70s, takes extract, filters, and it is the extractum of 1.18 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Ginkgo being broken to 80 mesh, adds the water microwave extracting of its weight 8 times, extraction power is 400W for the first time, extraction time
For 90s, second time extraction power is 350W, and extraction time is 70s, extraction for the first time and second time extraction time interval 70s, takes
Extract, filters, and it is the extractum of 1.25 that filtrate is concentrated into the relative density when 65 DEG C；
By Oleum sesami and Radix Folium Allii tuberosi extractum, Malus baccata (Linn.) Borkh. extractum, Folium Clerodendri Trichotomi extractum, Folium Ginkgo extractum, medical grade magnesium oxide, Gu Wei
Element, vitamin B6 mixing and stirring, obtain the special plaster of child virus diarrhea.
Embodiment 3, a kind of special plaster of child virus diarrhea, this plaster is made up of the raw material of following parts by weight,
Radix Folium Allii tuberosi 118 parts, Malus baccata (Linn.) Borkh. 25 parts, Folium Clerodendri Trichotomi 75 parts, Folium Ginkgo 25 parts, Oleum sesami 16 parts, medical grade magnesium oxide 4
Part, oryzanol 2.3 parts, vitamin B6 2.5 parts.
During making,
Radix Folium Allii tuberosi being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 9 times, extraction power is 425W for the first time, extraction
Time is 80s, and second time extraction power is 382W, and extraction time is 100s, extraction for the first time and second time extraction time interval
53s, takes extract, filters, and it is the extractum of 1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Malus baccata (Linn.) Borkh. being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 9 times, extraction power is 460W for the first time, extraction
Time is 60s, and second time extraction power is 410W, and extraction time is 30s, extraction for the first time and second time extraction time interval
65s, takes extract, filters, and it is the extractum of 1.21 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Clerodendri Trichotomi being broken to 80 mesh, adds the water microwave extracting of its weight 7 times, extraction power is 390W for the first time, during extraction
Between be 120s, second time extraction power is 325W, and extraction time is 80s, and for the first time extraction is spaced with second time extraction time
65s, takes extract, filters, and it is the extractum of 1.17 that filtrate is concentrated into the relative density when 65 DEG C；
Folium Ginkgo being broken to 80 mesh, adds the water microwave extracting of its weight 7 times, extraction power is 390W for the first time, extraction time
For 90s, second time extraction power is 345W, and extraction time is 70s, extraction for the first time and second time extraction time interval 65s, takes
Extract, filters, and it is the extractum of 1.24 that filtrate is concentrated into the relative density when 65 DEG C；
By Oleum sesami and Radix Folium Allii tuberosi extractum, Malus baccata (Linn.) Borkh. extractum, Folium Clerodendri Trichotomi extractum, Folium Ginkgo extractum, medical grade magnesium oxide, Gu Wei
Element, vitamin B6 mixing and stirring, obtain the special plaster of child virus diarrhea.
Choose health, the rat 80 of close 15 ages in days of body weight, every lumbar injection 1.8 hundred million escherichia coli O101Induction
Diarrhoea, after 12 hours, is randomly divided into A, B, C, D tetra-groups, often group 20 by rat, and A group clear water is applied in rat breastbone
Place；B group child of the present invention be applied at rat breastbone with plaster for cold；C group herbs ' water-decoctum is applied at rat breastbone,
The raw material of the following parts by weight of this herbs ' water-decoctum is made, Radix Folium Allii tuberosi 115-120 part, Malus baccata (Linn.) Borkh. 20-30 part, Folium Clerodendri Trichotomi 70-
80 parts, Folium Ginkgo 20-30 part, Radix Folium Allii tuberosi, Malus baccata (Linn.) Borkh., Folium Clerodendri Trichotomi, Folium Ginkgo, when making, are added 60-by this herbs ' water-decoctum
80 times of soak by water 30 minutes, D group Chinese medical concrete is applied at rat breastbone, the raw material system of the following parts by weight of this Chinese medical concrete
Becoming, Radix Folium Allii tuberosi 115-120 part, Malus baccata (Linn.) Borkh. 20-30 part, Folium Clerodendri Trichotomi 70-80 part, Folium Ginkgo 20-30 part, this Chinese medical concrete makes
Method is identical with matched group B.
Tri-groups of rats by intraperitoneal injection 1.8 hundred million escherichia coli O of A, B, C, D101After 12 hours, it be observed that tetra-groups of rats of A, B, C, D all go out
Existing spirit is depressed, diet reduces, the symptom of row's yellow loose stool, A, B, C, D tri-groups respectively with clear water, plaster, herbs ' water-decoctum, in
After medicine extractum processes 2 days, carrying out anatomic observation, two groups of mouse livers of A, C, kidney, spleen enlargement, duodenum is kermesinus,
Back segment intestinal tube is congested serious, and intestinal wall is thinning, and be translucent shape, is full of the thin content of yellow in intestinal tube, and caecum air-blowing, D group is little
Hepar Mus is dirty, the slightly enlargement of kidney, spleen, and duodenum is kermesinus, and hyperemia is not serious, and intestinal tube end has the thin content of yellow
Thing, caecum air-blowing, intestinal tube stage casing feces starts molding, and B group mouse liver, kidney, spleen have no that enlargement, duodenum are red
Color, intestinal tube is without hyperemia, and Di feces starts molding, and intestinal pathological changes is inconspicuous.
Claims (2)
1. the special plaster of child virus diarrhea, it is characterised in that this plaster is made up of the raw material of following parts by weight,
Radix Folium Allii tuberosi 115-120 part, Malus baccata (Linn.) Borkh. 20-30 part, Folium Clerodendri Trichotomi 70-80 part, Folium Ginkgo 20-30 part, Oleum sesami 15-18
Part, medical grade magnesium oxide 3-5 part, oryzanol 2-2.5 part, vitamin B6 2-3 part.
A kind of special plaster of child virus diarrhea the most according to claim 1, it is characterised in that this children's cold pastes
Cream making step is as follows:
Folium Musae being crushed to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 320-for the first time
350W, extraction time is 80s, and second time extraction power is 250-260W, and extraction time is 60s, extraction for the first time and second time
Extraction time interval 60-80s, takes extract, filters, and it is the extractum of 1.21-1.23 that filtrate is concentrated into the relative density when 65 DEG C；
Garfields Tea being broken to 80 mesh, adds the ethanol microwave extracting of its weight 8-10 times, extraction power is 380-for the first time
400W, extraction time is 100s, and second time extraction power is 300-320W, and extraction time is 50s, extraction for the first time and second time
Extraction time interval 60-80s, takes extract, filters, and it is the extractum of 1.18-1.2 that filtrate is concentrated into the relative density when 65 DEG C；
Flos althaeae roseae being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 420-430W for the first time,
Extraction time is 100s, and second time extraction power is 320-350W, and extraction time is 50s, extraction for the first time and second time extraction
Time interval 60-65s, takes extract, filters, and it is the extractum of 1.22-1.25 that filtrate is concentrated into the relative density when 65 DEG C；
Hemerocallis fulva L. being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-385W for the first time, extraction
The time of taking is 80s, and second time extraction power is 320-330W, and extraction time is 50s, extraction for the first time and second time extraction time
Interval 60-70s, takes extract, filters, and it is the extractum of 1.23-1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Caulis et folium clerodendri bungei being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 380-400W for the first time,
Extraction time is 60s, and second time extraction power is 230-250W, and extraction time is 30s, when extraction for the first time and second time extraction
Between be spaced 130-145s, take extract, filter, it is the extractum of 1.22-1.24 that filtrate is concentrated into the relative density when 65 DEG C；
Flos Trollii being crushed to 80 mesh, adds the water microwave extracting of its weight 6-8 times, extraction power is 345-350W for the first time,
Extraction time is 75s, and second time extraction power is 260-280W, and extraction time is 50s, when extraction for the first time and second time extraction
Between be spaced 65-70s, take extract, filter, it is the extractum of 1.21-1.22 that filtrate is concentrated into the relative density when 65 DEG C；
By hemp seed oil and Flos althaeae roseae extractum, Hemerocallis fulva L. extractum, Folium Musae extractum, Caulis et folium clerodendri bungei extractum, Black Draught, Flos Trollii leaching
Cream, safflower oil extractum, active hargil extractum, taurine extractum, aminophylline extractum mixing and stirring, obtain children's cold and use
Plaster.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610385965.6A CN106038946A (en) | 2016-06-03 | 2016-06-03 | Plaster special for child virus diarrhea |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610385965.6A CN106038946A (en) | 2016-06-03 | 2016-06-03 | Plaster special for child virus diarrhea |
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| CN106038946A true CN106038946A (en) | 2016-10-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610385965.6A Pending CN106038946A (en) | 2016-06-03 | 2016-06-03 | Plaster special for child virus diarrhea |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940891A (en) * | 2015-07-30 | 2015-09-30 | 太仓优活生物技术有限公司 | Medicine for treating diarrhea |
| CN105250639A (en) * | 2015-10-20 | 2016-01-20 | 张军 | Traditional Chinese medicine infantile navel plaster for treating infantile diarrhea |
-
2016
- 2016-06-03 CN CN201610385965.6A patent/CN106038946A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940891A (en) * | 2015-07-30 | 2015-09-30 | 太仓优活生物技术有限公司 | Medicine for treating diarrhea |
| CN105250639A (en) * | 2015-10-20 | 2016-01-20 | 张军 | Traditional Chinese medicine infantile navel plaster for treating infantile diarrhea |
Non-Patent Citations (3)
| Title |
|---|
| 宛志沪等编著: "《药用动植物种养加工技术 23 银杏》", 31 January 2001, 中国中医药出版社 * |
| 朱俊义等著: "《中国长白山木本植物彩色图志》", 30 September 2013, 吉林大学出版社 * |
| 李华龙主编: "《实用奇效良方》", 30 June 2013, 中原农民出版社 * |
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Application publication date: 20161026 |