CN106038668A - Medicine for controlling blood glucose concentration - Google Patents

Medicine for controlling blood glucose concentration Download PDF

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Publication number
CN106038668A
CN106038668A CN201610363719.0A CN201610363719A CN106038668A CN 106038668 A CN106038668 A CN 106038668A CN 201610363719 A CN201610363719 A CN 201610363719A CN 106038668 A CN106038668 A CN 106038668A
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Prior art keywords
medicine
radix trichosanthis
concentrated solution
radix
filtrate
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CN201610363719.0A
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CN106038668B (en
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杨本雷
杨舒雅
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Chuxiong Yi Autonomous Prefecture Yi medicine Research Institute
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杨本雷
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a medicine for controlling blood glucose concentration. The medicine is prepared from the following raw materials in parts by weight: 150-300 parts of radix trichosanthis, 100-200 parts of medicated leaven and 50-100 parts of wingedstem inula root. A preparation method comprises the following steps: (1) finely selecting and cleaning the adopted medicinal materials, weighing the radix trichosanthis and the medicated leaven, adding distilled water which is 2-4 times the total weight of the radix trichosanthis and the medicated leaven, decocting the materials together for 1-2h, boiling and extracting the materials and filtering medicine liquid by virtue of a screen which is 50-70 meshes, so that a filtrate is obtained; (2) concentrating the filtrate obtained in the step (1) until relative density is 1.25-1.35, so that a concentrated solution is obtained; and (3) weighting the wingedstem inula root, crushing the wingedstem inula root into fine powder of 100-140 meshes; adding the fine powder to the concentrated solution obtained in the step (2), uniformly mixing the fine powder and the concentrated solution, so that an appropriate soft material is obtained, drying the soft material, filling the dried soft material in capsules, so that the medicine is obtained. The medicine disclosed by the invention, by regulating spleen and stomach functions, can boost organism immunity; and the medicine has the advantages of being safe in treatment, concrete in curative effect, being capable of controlling the blood glucose concentration without rebound and the like.

Description

A kind of medicine controlling blood sugar concentration
Technical field
The present invention relates to Yi nationality's medicine technical field, a kind of medicine controlling blood sugar concentration.
Background technology
Diabetes are one group and increase the metabolic disease group being characterized with chronic blood glucose levels, and hyperglycemia is due to pancreas Island element hyposecretion and (or) insulin action defect cause.Diabetes can cause multiple organ, the infringement of multisystem, causes The chronic progressive external pathological changes of the tissue such as eye, kidney, nerve, heart, blood vessel, causes functional defect and exhaustion.
Diabetes are commonly encountered diseases, frequently-occurring disease, and its prevalence is just along with the raising of living standards of the people, aged tendency of population, life Live the change of mode and increase sharply, be a worldwide public health difficult problem for serious threat human health, according to incompletely statistics, mesh Front China diabetics about 3,000 ten thousand, the morbidity occupying 2, the world (the 1st India, the 3rd U.S.) type 2 diabetes mellitus is just tending to low In age, especially in developing country, in recent years finding that type 2 diabetes mellitus sickness rate in child also begins to rise, diabetes become The developed country's the third-largest non-infective disease disease after cardiovascular and tumor, brings white elephant to society and economy, sugar The preventing and treating of urine disease is very urgent.
Oral antidiabetic drug and insulin preparation blood sugar lowering are two big means for the treatment of diabetes at present, and oral antidiabetic drug is because of difference There is hepato-enteric circulation in degree, happening occasionally of insulin treatment drug resistance phenomenon, insulin is inconvenient to carry in addition, grinds from ethnic drug The preparation sending out blood sugar reducing function definite is imperative.
Summary of the invention
Technical problem solved by the invention is to provide a kind of medicine controlling blood sugar concentration, thus solves above-mentioned background Problem in technology.
Technical problem solved by the invention realizes by the following technical solutions:
A kind of medicine controlling blood sugar concentration, the raw material including following weight portion is prepared from:
Radix Trichosanthis 150-300, Massa Medicata Fermentata 100-200, Radix Inulae Pterocaulae 50-100.
In the present invention, as the preferred technical scheme of one, a kind of medicine controlling blood sugar concentration, including following weight portion Raw material be prepared from:
Radix Trichosanthis 170-270, Massa Medicata Fermentata 120-180, Radix Inulae Pterocaulae 70-80.
In the present invention, as the preferred technical scheme of one, a kind of medicine controlling blood sugar concentration, including following weight portion Raw material be prepared from:
Radix Trichosanthis 225, Massa Medicata Fermentata 150, Radix Inulae Pterocaulae 75.
In the present invention, as the preferred technical scheme of one, the preparation method of this medicine is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds 2-4 times of weight (Radix Trichosanthis, the gross weight of Massa Medicata Fermentata Amount) distilled water, decoct altogether 1-2 hour, boil carry rear medicinal liquid 50-70 eye mesh screen filter, obtain filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.25-1.35 obtain To concentrated solution;
(3) weigh Radix Inulae Pterocaulae, grind to form the fine powder of 100-140 mesh, and add in the concentrated solution of step (2), mixing, make Suitable soft material, is dried, and loads capsule, obtains this medicine.
In the present invention, as a kind of preferred technical scheme, preparation method is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds 3 times of weight (Radix Trichosanthis, gross weights of Massa Medicata Fermentata Amount) distilled water, decoct altogether 1.5 hours, boil and carry rear medicinal liquid and filter with 60 eye mesh screens, obtain filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.3 concentrated Liquid;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 120 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
In the present invention, Radix Trichosanthis [nature and flavor] hardship sweet, micro-, it is slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] clearing away heat and promoting production of body fluid, Detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat quenches one's thirst, sore swollen toxin.
Massa Medicata Fermentata [nature and flavor] sweet, acrid, warm.[return through] enters spleen, stomach warp.[function cures mainly] invigorating the spleen and regulating the stomach, helps digestion in tune.Control diet Stagnating, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point amasss.
Radix Inulae Pterocaulae [nature and flavor] is bitter, flat.[return through] attaches to the lung and stomach meridians.[function cures mainly] qi-restoratives, heat-clearing and toxic substances removing, treatment dizziness, the heart Unbearably, tinnitus, cold perspiration, carbuncle and ulcer toxic swelling etc..
Inventor thinks: diabetes motherland's medical science of coincideing " is quenched one's thirst " sick category, and Yi nationality doctor thinks that diabetes are innate deficiency, Disorder of emotion, eating and drinking without temperance etc. causes YIN fluid deficiency, scorching inclined Sheng, and with polydipsia, polyphagia, polyuria, emaciated physique, weak etc. is main A kind of disease to be showed, its sick position is at lung, taste, kidney, and treatment is with clearing heat and moistening dryness, and YIN nourishing and the production of body fluid promoting is the rule for the treatment of, and taste are the day after tomorrow Originally, the spleen and stomach function of Yi nationality doctor has contained the function of modern medicine pancreas, Massa Medicata Fermentata strengthening the spleen to promote digestion in preparation, and Radix Trichosanthis yin nourishing increases Liquid, big bitter medicine heat-clearing and toxic substances removing, closes square tube and overregulates spleen and stomach function, repair impaired pancreas, thus recover pancreatic secretion β cell merit And then can regulate and control internal blood glucose, this medicine changes exogenous supply insulin and the pattern of single antidiabetic drug glucose-lowering treatment.
Owing to have employed above technical scheme, the method have the advantages that
The present invention observes through 120 example diabetics clinical applications, and this medicine is to controlling diabetics on an empty stomach and after the meal blood Sugar determined curative effect, total effective rate 94%, clinical observation also finds that this medicine, without toxicity, and can well improve diabetics Three-many-one-little symptom, part of diabetes mellitus patient blood glucose stablize Hou Gaifu Yi nationality medicine Phenformin capsule after on an empty stomach and post-prandial glycemia is still put down Surely, this medicine is by regulation spleen and stomach function and then enhancing human body immunity power, and in clinical observation, this medicine has highlighted easy to carry, treatment peace Entirely, determined curative effect, the advantage such as glycemic control not bounce-back.
Detailed description of the invention
For the technological means making the present invention realize, creation characteristic, reach purpose and be easy to understand with effect, below knot Close specific embodiment, the present invention is expanded on further.
Embodiment 1
A kind of medicine controlling blood sugar concentration, the raw material including following weight portion is prepared from: Radix Trichosanthis 150 weight portion, Massa Medicata Fermentata 100 weight portion, Radix Inulae Pterocaulae 50 weight portion.
The preparation method of this medicine is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the distillation of 2 times of weight (i.e. 500 weight portion) Water, decocts 1 hour altogether, boils and carries rear medicinal liquid and filter with 50 eye mesh screens, obtains filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.25 concentrated Liquid;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 100 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
Embodiment 2
A kind of medicine controlling blood sugar concentration, the raw material including following weight portion is prepared from: Radix Trichosanthis 300 weight portion, Massa Medicata Fermentata 200 weight portion, Radix Inulae Pterocaulae 100 weight portion.
The preparation method of this medicine is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the distillation of 4 times of weight (2000 weight portion) Water, decocts 2 hours altogether, boils and carries rear medicinal liquid and filter with 70 eye mesh screens, obtains filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.35 concentrated Liquid;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 140 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
Embodiment 3
A kind of medicine controlling blood sugar concentration, the raw material including following weight portion is prepared from: Radix Trichosanthis 225 weight portion, Massa Medicata Fermentata 150 weight portion, Radix Inulae Pterocaulae 75 weight portion.
The preparation method of this medicine is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the distillation of 3 times of weight (i.e. 1125 weight portion) Water, decocts 1.5 hours altogether, boils and carries rear medicinal liquid and filter with 60 eye mesh screens, obtains filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.3 concentrated Liquid;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 120 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
Embodiment 4
A kind of medicine controlling blood sugar concentration, the raw material including following weight portion is prepared from: Radix Trichosanthis 170 weight portion, Massa Medicata Fermentata 180 weight portion, Radix Inulae Pterocaulae 70 weight portion.
The preparation method of this medicine is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the distillation of 2 times of weight (i.e. 700 weight portion) Water, decocts 1.5 hours altogether, boils and carries rear medicinal liquid and filter with 70 eye mesh screens, obtains filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.3 concentrated Liquid;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 140 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
Embodiment 5
A kind of medicine controlling blood sugar concentration, the raw material including following weight portion is prepared from: Radix Trichosanthis 270 weight portion, Massa Medicata Fermentata 120 weight portion, Radix Inulae Pterocaulae 75 weight portion.
The preparation method of this medicine is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the steaming of 2.5 times of weight (i.e. 975 weight portion) Distilled water, decocts 2 hours altogether, boils and carries rear medicinal liquid and filter with 65 eye mesh screens, obtains filtrate;
(2) filtrate that step (1) obtains is concentrated into (measuring when 45 DEG C-50 DEG C) when relative density is 1.35 concentrated Liquid;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 120 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
Treatment embodiment 1
Patient Xu certain, man, 54 years old, because " xerostomia, polydipsia companion become thin half a year " goes to a doctor, weight in patients 80K weight portion, previously body Strong, disease of being admitted to hospital is seen, xerostomia, polydipsia, every day amount of drinking water about 4000ml, weight loss 5K weight portion the most over the past half year, random blood of being admitted to hospital Sugar 33.5mmoL/L, next day fasting glucose 18.00mmoL/L, post-prandial glycemia 25.50mmoL/L, patient chest abdominal part coherence check returns Reporting without exception, it is considered to patient system diabetes, treatment is given insulin aspart 30 spy and is filled morning 25u, evening 15uGlucose-lowering treatment, after treating 3 days Patient blood glucose's monitoring result shows, patient's fasting glucose fluctuates in 8.00-9.50mmoL/L, and post-prandial glucose excursions is in 10.50- 11.00mmoL/L, patient treatment adds with Phenformin capsule each 5 on the 4th day, and three times a day, after add-on 3 days, monitoring is suffered from Fasting glucose of showing person's blood glucose fluctuates in 6.00-6.50mmoL/L, and post-prandial glucose excursions is in 7.00-8.50mmoL/L, patient blood glucose Control ideal, advise patient to abide by advise and continue to add Phenformin capsule.
Treatment embodiment 2
Patient Ma, man, 47 years old, because " polyorexia companion's nocturia March frequently " is medical, previously body was good for, and patient is admitted to hospital disease as many Food is easily hungry, nocturia 4-6 time, and be admitted to hospital random blood sugar 15.00mmoL/L, next day fasting glucose 8.34mmoL/L, post-prandial glycemia 14.20mmoL/L, it is considered to patient system diabetes, patient refuses row insulin and orally-taken blood sugar reducing sheet glucose-lowering treatment, is admitted to hospital and gives patient Each 5 of row orally-taken blood sugar reducing curing capsule, three times a day, starts to monitor patient blood glucose, blood sugar monitoring result display patient next day of taking medicine Fasting glucose fluctuates in 5.00-6.00mmoL/L, and post-prandial glucose excursions, in 7.00-8.10mmoL/L, advises patient to continue to abide by and advise clothes Use Phenformin capsule glucose-lowering treatment.
Treatment embodiment 3
Patient king so-and-so, man, 59 years old, because " find high blood glucose companion blurred vision 2 years " goes to a doctor.Body weight 70K weight portion, suffers from Person's private prosecution showed fasting glucose 8.00mmoL/L, post-prandial glycemia 10.50mmoL/L, the conscious diet of patient in outer court's health check-up before 2 years, slept Sleep and body weight is as usual, blurred vision over nearly 2 years, admission day fasting glucose 8.50mmoL/L, post-prandial glycemia 11.00mmoL/L, Consider that patient system diabetes, treatment are given insulin aspart 30 spy and filled morning 20u, evening 15uMerge Phenformin capsule three times a day, each 5 Grain glucose-lowering treatment, plays monitoring blood glucose display fasting glucose 6.00mmoL/L next day, and post-prandial glycemia 8.00mmoL/L, treatment continues 3 Use with patient insulin's decrement after it and fill morning 14 for insulin aspart 30 spyu, evening 10uAnd it is the most front to continue to be aided with Phenformin capsule Dosage, monitors patient blood glucose subsequently, and display fasting glucose fluctuates in 5.50-6.50mmoL/L, and post-prandial glucose excursions is in 7.00- 8.20mmoL/L。
The ultimate principle of the present invention and principal character and advantages of the present invention have more than been shown and described.The technology of the industry Personnel, it should be appreciated that the present invention is not restricted to the described embodiments, simply illustrating this described in above-described embodiment and description The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these become Change and improvement both falls within scope of the claimed invention.Claimed scope by appending claims and Equivalent defines.

Claims (5)

1. the medicine controlling blood sugar concentration, it is characterised in that: include that the raw material of following weight portion is prepared from:
Radix Trichosanthis 150-300, Massa Medicata Fermentata 100-200, Radix Inulae Pterocaulae 50-100.
A kind of medicine controlling blood sugar concentration the most according to claim 1, it is characterised in that: include the former of following weight portion Material is prepared from:
Radix Trichosanthis 170-270, Massa Medicata Fermentata 120-180, Radix Inulae Pterocaulae 70-80.
A kind of medicine controlling blood sugar concentration the most according to claim 1, it is characterised in that: include the former of following weight portion Material is prepared from:
Radix Trichosanthis 225, Massa Medicata Fermentata 150, Radix Inulae Pterocaulae 75.
A kind of medicine controlling blood sugar concentration the most according to claim 1, it is characterised in that: preparation method is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the distilled water of 2-4 times of weight, decoct altogether 1-2 hour, Boil and propose the filtration of rear medicinal liquid 50-70 eye mesh screen, obtain filtrate;
(2) filtrate that step (1) obtains is concentrated into when relative density is 1.25-1.35 obtains concentrated solution;
(3) weighing Radix Inulae Pterocaulae, grind to form the fine powder of 100-140 mesh, and add in the concentrated solution of step (2), mixing, it is suitable to make Soft material, be dried, load capsule, obtain this medicine.
A kind of medicine controlling blood sugar concentration the most according to claim 4, it is characterised in that: preparation method is:
(1) selected and clean medicine used, weighs Radix Trichosanthis, Massa Medicata Fermentata, adds the distilled water of 3 times of weight, decoct altogether 1.5 hours, boil Carry rear medicinal liquid to filter with 60 eye mesh screens, obtain filtrate;
(2) filtrate that step (1) obtains is concentrated into when relative density is 1.3 obtains concentrated solution;
(3) weigh Radix Inulae Pterocaulae, grind to form the fine powder of 120 mesh, and add in the concentrated solution of step (2), mixing, make suitable soft Material, is dried, and loads capsule, obtains this medicine.
CN201610363719.0A 2016-05-28 2016-05-28 A kind of medicine for controlling blood sugar concentration Active CN106038668B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106975003A (en) * 2017-03-16 2017-07-25 杨本雷 A kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application

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CN1294912A (en) * 1999-11-05 2001-05-16 中国人民解放军军事医学科学院放射医学研究所 Blood sugar reducing compound
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106975003A (en) * 2017-03-16 2017-07-25 杨本雷 A kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application

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