CN106975003A - A kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application - Google Patents
A kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application Download PDFInfo
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- 230000002218 hypoglycaemic effect Effects 0.000 title claims abstract description 47
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 17
- 235000005340 Asparagus officinalis Nutrition 0.000 claims abstract description 17
- 240000005528 Arctium lappa Species 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 14
- 238000012805 post-processing Methods 0.000 claims abstract description 9
- 238000002203 pretreatment Methods 0.000 claims abstract description 9
- 238000000605 extraction Methods 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 239000006187 pill Substances 0.000 claims abstract description 4
- 239000003826 tablet Substances 0.000 claims abstract description 4
- 244000003416 Asparagus officinalis Species 0.000 claims abstract 3
- 239000000706 filtrate Substances 0.000 claims description 28
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- 229940079593 drug Drugs 0.000 claims description 9
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- 238000007873 sieving Methods 0.000 claims description 5
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- 238000007598 dipping method Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
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- 238000005303 weighing Methods 0.000 claims description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application.The pharmaceutical composition of described hypoglycemic includes 100~300 parts of Pachyrhizua angulatus, 50~250 parts of lucid asparagus, 50~150 parts of the great burdock achene of parts by weight of raw materials, is prepared through pre-treatment, extraction and post-processing step.Preparation is adds tablet, powder, capsule, granule and pill prepared by pharmaceutically acceptable auxiliary material in the pharmaceutical composition of described hypoglycemic.Using application of the pharmaceutical composition for described hypoglycemic in hypoglycemic medicine is prepared.The all medicine joints of the present invention, synergy plays clearing heat and moistening dryness, the effect of nourishing Yin and promoting production of body fluid is clinically used for the treatment of diabetes altogether.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation
With application.
Background technology
Diabetes are one group and are increased the metabolic disease group being characterized with chronic blood glucose (abbreviation blood glucose) level.High blood
Sugar is due to that defect of insulin secretion and (or) insulin action defect cause.In addition to carbohydrate, still there are protein, fat
Metabolic disorder.Prolonged illness can cause multiple organ, the infringement of multisystem, cause the tissues such as eye, kidney, nerve, heart, blood vessel it is chronic enter
Row venereal disease becomes, and causes functional defect and exhaustion.Be in a bad way or stress when can occur the acute metablize confusion, such as DKA,
Hyperosmolar coma etc..This disease reduces patients ' life quality, and life time shortens, case fatality rate increase.
Diabetes are common diseases, frequently-occurring disease, and its illness rate is just with the improvement of people's living standards, aging population, raw
The change of mode living and increase sharply.Estimate according to the World Health Organization (WHO), the whole world has more than 1.5 hundred million diabetics at present,
By 2025, this numeral will be doubled.Current China diabetic about 3,000 ten thousand, occupies 2, the world (the 1st India, the 3rd
The position U.S.).The morbidity forward direction of diabetes B is become younger, and general population is spread, especially in developing country, and 2 types sugar is found in recent years
Urine disease incidence of disease in children also begins to rise, and it is the third-largest non-after cardiovascular and tumour that diabetes have turned into developed country
Infectious disease disease, white elephant is carried out to society and economy-zone, is the worldwide public health problem of serious threat human health,
The preventing and treating of diabetes is very urgent.
The cause of disease and pathogenesis of diabetes not yet fully understand, lack etiotropic treatment, current OHA
It is two big Main Means for the treatment of diabetes with injected Forms of Insulin, insulin therapy resistance phenomenon happens occasionally, and takes
Band inconvenience, is difficult keeping, thus it is very urgent to find the new medicinal preparation for the treatment of diabetes.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition of hypoglycemic；Second purpose is the drop described in offer
The preparation method of the pharmaceutical composition of sugar；3rd purpose is the preparation of the pharmaceutical composition of the hypoglycemic described in offer；4th mesh
Be provide described in hypoglycemic pharmaceutical composition application.
The first object of the present invention is achieved in that the pharmaceutical composition of described hypoglycemic includes the powder of parts by weight of raw materials
100~300 parts of Pueraria lobota, 50~250 parts of lucid asparagus, 50~150 parts of great burdock achene, are prepared into through pre-treatment, extraction and post-processing step
Arrive.
The second object of the present invention is achieved in that including pre-treatment, extraction and post-processing step, is specifically included：
A, selected and clean bulk drug, are then uniformly mixed so as to obtain material a standby by formulation ratio weighing bulk drug；
B, alcohol solution dipping 7~10 days will be added in material a, and be filtrated to get filtrate b and filter residue c；
C, the water that 8~12 times of filter residue c weight is added in filter residue c boiled carry 3~4 times, every time 0.5~1.5h, merging filtrate,
It is concentrated to give thick paste d；
D, filtrate b is concentrated to give thick paste e, thick paste d and thick paste e is well mixed, drying and crushing sieving obtains object
The pharmaceutical composition of hypoglycemic.
The third object of the present invention be achieved in that in the pharmaceutical composition of described hypoglycemic add it is pharmaceutically acceptable
Auxiliary material prepare tablet, powder, capsule, granule and pill.
The fourth object of the present invention is achieved in that the pharmaceutical composition of described hypoglycemic in hypoglycemic medicine is prepared
Using.
Inventor thinks：Diabetes spp motherland medical science " quenching one's thirst " disease category, early in 2nd century of Christian era,《The Yellow Emperor's Canon of Internal Medicine》It is existing
The discussion of " quenching one's thirst " disease, it is believed that it is insufficiency of natural endowment to quench one's thirst, disorder of emotion, eating and drinking without temperance etc. causes YIN fluid deficiency, it is scorching it is inclined contain, because
Treated in lung, taste, kidney with clear a kind of many drinks, many foods, diuresis, disease that body becomes thin weak grade mainly to show, its sick position
Heat is moisturized, and nourishing Yin and promoting production of body fluid is the rules for the treatment of.
Pachyrhizua angulatus relieving restlessness is quenched the thirst in side of the present invention, lucid asparagus enriching yin, is moisturized, clearing lung-heat, fall fire, great burdock achene wind-dispelling heat-dissipating, modern
Pharmacological research, plays the role of to reduce blood glucose.All medicine joints, synergy plays clearing heat and moistening dryness altogether, and the effect of nourishing Yin and promoting production of body fluid, clinic is used
In the treatment of diabetes.
Pachyrhizua angulatus in prescription of the present invention,【Base】For the root tuber of legume Pueraria lobota.【Meridian distribution of property and flavor】It is Gan Xin, flat.Enter spleen, stomach
Through.【Function is cured mainly】Rising Yang expelling pathogenic factors from muscles and skin, promoting eruption antidiarrheal, relieving restlessness is quenched the thirst.Modern pharmacology research shows that Pueraria lobata is oral to rabbit,
Start the rising of 2 hours blood glucoses, decline immediately, the 3rd, 4 hours decline it is most fast.
Lucid asparagus,【Base】For the root tuber of liliaceous plant lucid asparagus.【Meridian distribution of property and flavor】Sweetness and bitterness, trembles with fear.Enter lung, kidney channel.【Work(
With curing mainly】Enriching yin, moisturizes, clearing lung-heat, fall fire.Fever due to yin deficiency is controlled, cough is spitted blood, and lung carbuncle, consumptive lung disease, abscess of throat is quenched one's thirst, constipation.
《Haigoushen》：The main lung qi of lucid asparagus coughs inverse, rush of panting urgency, except heat, leads to kidney qi, treats consumptive lung disease, lung carbuncle, abscess of throat is quenched one's thirst, just
It is secret.
Great burdock achene,【Base】For the fruit of feverfew burdock.【Meridian distribution of property and flavor】It is arduous, it is cool.Attach to the lung and stomach meridians.【Function master
Control】Wind-dispelling heat-dissipating, facilitaing lung promoting eruption, swelling and pain relieving.Cough due to wind-heat evil is treated, abscess of throat, macula is impermeable, and rubella is had an itch, carbuncle swells sore
Poison.【Modern pharmacological research is pointed out】Burdock extract can significantly and enduringly reduce rat blood sugar, to carbohydrate tolerance
Increase.
The invention has the advantages that：
Inventor is observed by the clinical application of 150 diabetics, and the medicine plays the role of to reduce blood glucose, always has
Efficiency 94%, can preferably reduce the generation of diabetes, while improving " three-many-one-little " symptom of diabetic, clinical observation
Toxicity is not found, it is shown that pharmaceutical composition of the present invention is easy to carry, safely controllable, determined curative effect, no toxicity
Advantage.
Embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention is not any limitation as in any way,
Based on present invention teach that any conversion or replacement made, belong to protection scope of the present invention.
100~300 parts of the Pachyrhizua angulatus of the pharmaceutical composition of described hypoglycemic including parts by weight of raw materials, 50~250 parts of lucid asparagus,
50~150 parts of great burdock achene, is prepared through pre-treatment, extraction and post-processing step.
The pharmaceutical composition of described hypoglycemic includes 150~300 parts of the Pachyrhizua angulatus of parts by weight of raw materials, lucid asparagus 100~200
Part, 50~100 parts of great burdock achene, are prepared through pre-treatment, extraction and post-processing step.
The preparation method of the pharmaceutical composition of hypoglycemic of the present invention, including pre-treatment, extraction and post-processing step, tool
Body includes：
A, selected and clean bulk drug, are then uniformly mixed so as to obtain material a standby by formulation ratio weighing bulk drug；
B, alcohol solution dipping 7~10 days will be added in material a, and be filtrated to get filtrate b and filter residue c；
C, the water that 8~12 times of filter residue c weight is added in filter residue c boiled carry 3~4 times, every time 0.5~1.5h, merging filtrate,
It is concentrated to give thick paste d；
D, filtrate b is concentrated to give thick paste e, thick paste d and thick paste e is well mixed, drying and crushing sieving obtains object
The pharmaceutical composition of hypoglycemic.
The concentration expressed in percentage by volume of ethanol solution described in step B is 60~80%.
The concentration expressed in percentage by volume of described ethanol solution is 70%.
The temperature soaked in step B is 20~40 DEG C.
Pulverizing and sieving described in D steps is to crush 200 mesh sieves.
The preparation of the pharmaceutical composition of hypoglycemic of the present invention for described hypoglycemic pharmaceutical composition in add pharmacy
Tablet, powder, capsule, granule and pill prepared by upper acceptable auxiliary material.
The application of the pharmaceutical composition of hypoglycemic of the present invention is preparing hypoglycemic for the pharmaceutical composition of described hypoglycemic
Application in medicine.
Method concrete operations prepared by the pharmaceutical composition of hypoglycemic of the present invention are as follows：
(1) selected and clean medicine used, weighs Pachyrhizua angulatus, lucid asparagus, great burdock achene, adds 70% ethanol immersion 7~10
It filters to obtain alcohol liquid, and alcohol liquid is concentrated under reduced pressure to obtain thick paste.
(2) the remaining dregs of a decoction of step (1) are added water to boil and carried 3-4 times, 1 hour every time, filtering was collected filtrate, is concentrated to give thick
Cream.
(3) thick paste obtained by step (1) and (2) is well mixed, dry, pulverize to obtain semi-finished product powder.
(4) semi-finished product are dispensed into obtain finished product, packing specification is 6g/ bags, and 100g/ bottles, every gram of finished product is equivalent to primary crude drug
10 grams.
(5) application method and the course for the treatment of：Warm water takes, each 6g, and 3 times a day, is a course for the treatment of per 15-30 days.
So that case is embodied, the present invention will be further described below：
Embodiment 1
Raw material Pachyrhizua angulatus 100g, lucid asparagus 50g, great burdock achene 50g are taken, the concentration expressed in percentage by volume of 5 times of raw material gross weight is added
80% ethanol solution, in being soaked 10 days at 20 DEG C of temperature, is filtrated to get filtrate and filter residue, filtrate is concentrated to give thick paste e；Filter residue
The middle water for adding 12 times of filter residue, which is boiled, to be carried 4 times, and 1 hour every time, filtering collected filtrate, thick paste d is concentrated to give, by thick paste d and thick paste e
It is well mixed to crush the pharmaceutical composition that 200 mesh sieves obtain object hypoglycemic.
Embodiment 2
Raw material Pachyrhizua angulatus 300g, lucid asparagus 250g, great burdock achene 150g are taken, the concentration expressed in percentage by volume of 3 times of raw material gross weight is added
60% ethanol solution, in being soaked 10 days at 40 DEG C of temperature, is filtrated to get filtrate and filter residue, filtrate is concentrated to give thick paste e；Filter residue
The middle water for adding 8 times of filter residue, which is boiled, to be carried 3 times, and 1 hour every time, filtering collected filtrate, is concentrated to give thick paste d, thick paste d and thick paste e are mixed
Conjunction uniformly crushed the pharmaceutical composition that 200 mesh sieves obtain object hypoglycemic.
Embodiment 3
Raw material Pachyrhizua angulatus 200g, lucid asparagus 150g, great burdock achene 100g are taken, the concentration expressed in percentage by volume of 4 times of raw material gross weight is added
70% ethanol solution, in being soaked 8 days at 30 DEG C of temperature, is filtrated to get filtrate and filter residue, filtrate is concentrated to give thick paste e；Filter residue
The middle water for adding 10 times of filter residue, which is boiled, to be carried 4 times, and 1 hour every time, filtering collected filtrate, thick paste d is concentrated to give, by thick paste d and thick paste e
It is well mixed to crush the pharmaceutical composition that 200 mesh sieves obtain object hypoglycemic.
Embodiment 4
Raw material Pachyrhizua angulatus 150g, lucid asparagus 100g, great burdock achene 100g are taken, the concentration expressed in percentage by volume of 5 times of raw material gross weight is added
80% ethanol solution, in being soaked 7 days at 40 DEG C of temperature, is filtrated to get filtrate and filter residue, filtrate is concentrated to give thick paste e；Filter residue
The middle water for adding 8 times of filter residue, which is boiled, to be carried 4 times, and 1 hour every time, filtering collected filtrate, is concentrated to give thick paste d, thick paste d and thick paste e are mixed
Conjunction uniformly crushed the pharmaceutical composition that 200 mesh sieves obtain object hypoglycemic.
Embodiment 5
Raw material Pachyrhizua angulatus 300g, lucid asparagus 200g, great burdock achene 200g are taken, the concentration expressed in percentage by volume of 3 times of raw material gross weight is added
60% ethanol solution, in being soaked 10 days at 40 DEG C of temperature, is filtrated to get filtrate and filter residue, filtrate is concentrated to give thick paste e；Filter residue
The middle water for adding 12 times of filter residue, which is boiled, to be carried 4 times, and 1 hour every time, filtering collected filtrate, thick paste d is concentrated to give, by thick paste d and thick paste e
It is well mixed to crush the pharmaceutical composition that 200 mesh sieves obtain object hypoglycemic.
Embodiment 6
Raw material Pachyrhizua angulatus 150g, lucid asparagus 200g, great burdock achene 100g are taken, the concentration expressed in percentage by volume of 4 times of raw material gross weight is added
70% ethanol solution, in being soaked 7 days at 30 DEG C of temperature, is filtrated to get filtrate and filter residue, filtrate is concentrated to give thick paste e；Filter residue
The middle water for adding 10 times of filter residue, which is boiled, to be carried 4 times, and 1 hour every time, filtering collected filtrate, thick paste d is concentrated to give, by thick paste d and thick paste e
It is well mixed to crush the pharmaceutical composition that 200 mesh sieves obtain object hypoglycemic.
Embodiment 7
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition of the hypoglycemic prepared with embodiment 2 to prepare in flakes
Agent.
Embodiment 8
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition of the hypoglycemic prepared with embodiment 1 and is prepared into capsule
Agent.
Embodiment 9
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition of the hypoglycemic prepared with embodiment 4 and is prepared into particle
Agent.
Embodiment 10
Pharmaceutically acceptable auxiliary material is added in the pharmaceutical composition of the hypoglycemic prepared with embodiment 6 and prepares pelletization
Agent.
Embodiment 11
The pharmaceutical composition prepared respectively with 1~embodiment of embodiment 6 carries out clinical test, and total effective rate reaches
94.00%.It is described further below with part real case：
Patient Xu certain, man, 56 years old, height 1.75m, because of " dry, many drinks with become thin half a year " medical, body weight 80KG, the past
Body is good for, symptoms include, dry, many drinks, daily amount of drinking water about 3500ml, over the past half year closely Body weight loss 6KG, random blood sugar 11.5mmoL/
L, next day fasting blood-glucose 9.50mmoL/L, postprandial blood sugar 11.00mmoL/L, thorax abdomen coherence check return is without exception, diagnosis：Sugar
Urine disease.Take the pharmaceutical composition that the embodiment of the present invention 1 is prepared, each 6g, 3 times a day, treats the 3rd day and surveys fasting blood-glucose
8.00mmoL/L, postprandial blood sugar 9.10mmoL/L, treatment are effective, and fasting blood-glucose 7.00mmoL/L, postprandial blood sugar are surveyed after one week
8.00mmoL/L, treatment first quarter moon surveys fasting blood-glucose 6.10mmoL/L, postprandial blood sugar 7.20mmoL/L, controls patient and is showed without discomfort,
Advise the same scheme glucose-lowering treatment of patient, regular follow-up.
Patient Ma, man, 47 years old, because " polyorexia with enuresis nocturna frequency March " goes to a doctor, ferritic was healthy, symptoms include：Polyorexia,
Enuresis nocturna 4-6 times, random blood sugar 12.00mmoL/L, fasting blood-glucose 8.34mmoL/L, postprandial blood sugar 10.20mmoL/L, diagnosis：Sugar
Urine disease.Patient refuses insulin and oral western medicine glucose-lowering treatment, takes the pharmaceutical composition that the embodiment of the present invention 3 is prepared,
Each 6g, 3 times a day, and medication next day starts to monitor patient blood glucose, blood sugar monitoring result show patient's fasting blood-glucose fluctuate in
5.00-6.00mmoL/L, post-prandial glucose excursions are in 7.00-8.10mmoL/L, and follow-up patient tests oneself fasting blood-glucose after treatment first quarter moon
5.50mmoL/L, post-prandial glucose excursions are in 6.50mmoL/L, and patient's treatment is effective, regular follow-up.
Patient Mr. Wang, man, 59 years old, because " find high blood glucose companion eye-blurred 2 years " goes to a doctor.Height 1.6m, body weight
70KG, patient pointed out fasting blood-glucose 8.00mmoL/L before 2 years in outer court's physical examination, and postprandial blood sugar 10.50mmoL/L, patient feels drink
Food, sleep and body weight are as usual, eye-blurred over nearly 2 years, admission day fasting blood-glucose 8.50mmoL/L, postprandial blood sugar
11.00mmoL/L, diagnosis：Diabetes.The pharmaceutical composition that the embodiment of the present invention 6 is prepared is taken, 3 times a day, each 6g,
Fasting blood-glucose 7.20mmoL/L, postprandial blood sugar 9.00mmoL/L are surveyed from morning next day, treats 3 days and surveys fasting blood-glucose 6.00mmoL/L,
January is surveyed fasting blood-glucose 5.80mmoL/L in postprandial blood sugar 7.50mmoL/L, treatment, and postprandial blood sugar 6.00mmoL/L, patient's treatment has
Effect, continues follow-up.
The present invention is not limited to the above embodiments, simply illustrates the present invention described in above-described embodiment and specification
Principle, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, and these change and changed
Enter all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
Define.
Claims (9)
1. a kind of pharmaceutical composition of hypoglycemic, it is characterised in that the pharmaceutical composition of described hypoglycemic includes the powder of parts by weight of raw materials
100~300 parts of Pueraria lobota, 50~250 parts of lucid asparagus, 50~150 parts of great burdock achene, are prepared into through pre-treatment, extraction and post-processing step
Arrive.
2. the pharmaceutical composition of hypoglycemic according to claim 1, it is characterised in that the pharmaceutical composition bag of described hypoglycemic
Include 150~300 parts of Pachyrhizua angulatus, 100~200 parts of lucid asparagus, 50~100 parts of the great burdock achene of parts by weight of raw materials, through pre-treatment, extract and
Post-processing step is prepared.
3. a kind of preparation method of the pharmaceutical composition of the hypoglycemic described in claim 1 or 2, it is characterised in that including pre-treatment,
Extract and post-processing step, specifically include：
A, selected and clean bulk drug, are then uniformly mixed so as to obtain material a standby by formulation ratio weighing bulk drug；
B, alcohol solution dipping 7~10 days will be added in material a, and be filtrated to get filtrate b and filter residue c；
C, the water that 8~12 times of filter residue c weight is added in filter residue c boiled carry 3~4 times, every time 0.5~1.5h, merging filtrate, concentration
Obtain thick paste d；
D, filtrate b is concentrated to give thick paste e, thick paste d and thick paste e is well mixed, drying and crushing sieving obtains object hypoglycemic
Pharmaceutical composition.
4. preparation method according to claim 3, it is characterised in that the volume basis of the ethanol solution described in step B is dense
Spend for 60~80%.
5. the preparation method according to claim 3 or 4, it is characterised in that the concentration expressed in percentage by volume of described ethanol solution is
70%.
6. preparation method according to claim 3, it is characterised in that the temperature soaked in step B is 20~40 DEG C.
7. preparation method according to claim 3, it is characterised in that pulverizing and sieving described in D steps is to crush 200
Mesh sieve.
8. a kind of preparation of the pharmaceutical composition of the hypoglycemic described in claim 1 or 2, it is characterised in that the medicine of described hypoglycemic
Tablet, powder, capsule, granule and pill prepared by pharmaceutically acceptable auxiliary material are added in composition.
9. a kind of application of the pharmaceutical composition of the hypoglycemic described in claim 1 or 2, it is characterised in that the medicine of described hypoglycemic
Application of the composition in hypoglycemic medicine is prepared.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710156692.2A CN106975003A (en) | 2017-03-16 | 2017-03-16 | A kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710156692.2A CN106975003A (en) | 2017-03-16 | 2017-03-16 | A kind of pharmaceutical composition of hypoglycemic and preparation method thereof, preparation and application |
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| CN106975003A true CN106975003A (en) | 2017-07-25 |
Family
ID=59339772
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179328A (en) * | 1997-11-14 | 1998-04-22 | 王辉 | Medicine and food for treating diabetes and producing method thereof |
| RU2161039C1 (en) * | 2000-06-01 | 2000-12-27 | Научно-исследовательский центр традиционной фитотерапии | Method of treatment of patients with insulin-dependent diabetes mellitus and medicinal species for treatment of patients with insulin-dependent diabetes mellitus |
| CN104873877A (en) * | 2015-06-09 | 2015-09-02 | 张保全 | Blood-sugar-lowering and body-constitution-conditioning traditional Chinese medicinal composition |
| CN106038668A (en) * | 2016-05-28 | 2016-10-26 | 杨本雷 | Medicine for controlling blood glucose concentration |
-
2017
- 2017-03-16 CN CN201710156692.2A patent/CN106975003A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179328A (en) * | 1997-11-14 | 1998-04-22 | 王辉 | Medicine and food for treating diabetes and producing method thereof |
| RU2161039C1 (en) * | 2000-06-01 | 2000-12-27 | Научно-исследовательский центр традиционной фитотерапии | Method of treatment of patients with insulin-dependent diabetes mellitus and medicinal species for treatment of patients with insulin-dependent diabetes mellitus |
| CN104873877A (en) * | 2015-06-09 | 2015-09-02 | 张保全 | Blood-sugar-lowering and body-constitution-conditioning traditional Chinese medicinal composition |
| CN106038668A (en) * | 2016-05-28 | 2016-10-26 | 杨本雷 | Medicine for controlling blood glucose concentration |
Non-Patent Citations (1)
| Title |
|---|
| 李浩等: "《中华药膳防治糖尿病》", 28 February 2001, 科学技术文献出版社 * |
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