CN106729304B - A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof - Google Patents
A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention provides a kind of Chinese medicines for mitigating fasting or side reaction of dieting and preparation method thereof.Said preparation ingredient is ginseng, the fruit of Chinese wolfberry, arillus longan, Semen Lablab Album, jujube, Chinese cassia tree, fructus amomi, dried orange peel, Pogostemon cablin, sealwort, Radix Glycyrrhizae.Full side links closely the interpretation of the cause, onset and process of an illness variation under fasting state, all medicine reasonable compatibilities, gather altogether Wen Yang, tonifying Qi, change turbid, replenishing essence work(.Receive hunger and other side reactions that the crowd of fasting is likely to occur in the fasted state for mitigating.Preliminary clinical test shows inventive formulation definite effect, and effect is rapid, no toxicity, can receive the ability and compliance of the resistance to starvation of fasting crowd with significant increase.
Description
Technical field
The present invention relates to medicine preparation and heat limitation field, more particularly, in a kind of mitigation fasting or diet side reaction
Medicine and preparation method thereof.
Background technology
Medically described fasting refers to be daily zero by the heat of alimentary canal dietary intake.But as a kind of health care
Method, the definition of fasting is more wide in range, and the definition with very low calorie diet, which has, to intersect, and refers to the heat taken in daily from alimentary canal
Less than 200-400 kilocalories, so following fasting includes very low calorie diet.
Fasting has been carried out more than 100 years in Europe as a kind of health care therapeutic method, can treat fatty liver, high blood
Press disease, blood fat disorder, obesity and overweight, diabetes B, sleep apnea syndrome, metabolic syndrome；Rheumatism joint
Inflammation, psoriasis, allergy, allergic rhinitis；Constipation, enterogastric diseases, irritable bowel syndrome；Osteoarthritis, tendon disease, back
Bitterly；Asthma, flu, influenza, bronchitis；Candidiasis, headache, menopausal syndrome, smoking, excessive drinking, acne；Etc..
Appropriate fasting can find evidence, mechanism bag in the above-mentioned disease of clinical treatment from many laboratory researches
Autophagy is included, inhibits inflammatory factor, anti-oxidant, stem cell regenerating, be immunized and restart, inhibit tumor growth factor, improve cognitive function,
Etc..
Fasting is not Europe original creation, just has " warding off paddy " health preserving method in the epoch China in even more time immemorial, from road
" not eating five cereals " in family's health, is a kind of common Curing Method of ancients.It starts from the pre-Qin days, is popular in the Tang Dynasty, also known as but paddy,
Go paddy, exhausted paddy, go without food, but grain, stop grain etc..
The earliest record of paddy is warded off to be derived from《The carefree trip of village》：" here the mountain that small aunt penetrates has extraordinary person residence.If skin ice and snow, mire
If about virgin does not eat five cereals, inhale wind and drink dew, multiply thin clouds, drive flying dragon, and swim outside the four seas ... " as a kind of macrobiosis benefit
It is also on the books in many ancient book ancient books and records to ward off paddy for the health rule in longevity.For example,《Wash you》Have " deficiency of food and it is convinced, be that must enjoy day
Year " is said；《Dadailiji easily this life》It says：" food meat person is brave and brave, eats paddy person wisdom and skilful, eats gas person gods and the longevity, no
Trencherman is not dead and refreshing." illustrate that warding off paddy plays the role of promoting longevity.
After Taoism is founded, this art is followed, paddy person is warded off in cultivation, for not incapable persons.Record sweet wormwood application method《Preemergency after elbow
Side》, mono- Taoist priests of author Ge Hongnai,《Baopuzi neipian is miscellaneous should》Middle theory：" remainder is shown in that 2 years 3 years persons of disconnected paddy people are more, all
The light color of body is good.”
Ancients have also spoken of the side reaction for warding off paddy and its solution party in addition to finding to ward off the health cultivation and rehabilitation positive effect of paddy
Case.Western Han Dynastry's book copied on silk that Changsha Mawangdui is unearthed《(but) paddy is gone to eat a gas piece》Cloud：" (but) paddy person is gone to eat pyrrosia lingua.Head weights, foot are light, body
It is cooked a meal and (blown) to sorrowful , Ze Xu (Xu), stops depending on profit." mean the hunger phenomenon that top-heavy limbs fatigue is often generated when warding off paddy,
Solution has two aspects, when the pyrrosia lingua that takes traditional Chinese medicine, first, with " blowing Xu " food gas (convinced), i.e., soft slow elongated breath is received.
The convinced principle for warding off paddy is explained：Saliva, empty gas and water are by swallowing, correct Breathing Method, into alimentary canal
It is interior, nutriment is synthesized in vivo, is sustained life so as to not eat five cereals for a long time.This method may look like psychology
Hint mitigate hunger, it is but incompatible with modern scientific theory.
On using Chinese medicine,《Cloud book box seven is signed》Volume five carries, and Sun You high mountains " eat art but grain, take paddy celestial being ball 67 years, face is color light
Profit, essence are refreshing elegant clean." ward off the medicine that paddy takes, have glutinous rehmannia, sealwort, the fleece-flower root, the fruit of Chinese wolfberry, lucid asparagus, the tuber of dwarf lilyturf, chrysanthemum, Poria cocos,
Rhizoma Atractylodis Macrocephalae, pine nut, cedar seed, the seed of jog's tears, Chinese yam, almond, Radix Paeoniae Alba, calamus, rhizoma alismatis, pyrrosia lingua etc..The Chinese medicine preparation five of each utilization spends eight
Door, but be to carry out the thinking of principle-method-recipe-medicines by the tcm symptom sign occurred to patient during fasting and distinguish without one
Card treats, and effect leaves a question open.
At present in addition to applicant and Chen Dingsheng (the cooperation post-doctor of applicant), almost without for fasting side reaction
Chinese prescription invention.And my previous invention is made of Chinese medicine, can only declare Chinese medicine preparation is made exists by new drug
Hospital circulates, it is impossible to is widely used as food.
According to the research of Chinese fasting treatment founder Qin Jian et al., fasting or diet can ward off paddy and gone out with being similar to
Existing side reaction：Limb is cold, chilly, tired, weak, dizzy bored, thick greasy fur.The core of these side reactions is hunger, can be compeled
The people that fasting in need carries out health care is made to be difficult to adhere to or give up halfway.
We by occur during fasting tcm symptom analysis and Dialectical thought, fasting crowd occur limb it is cold, fear
It is cold, belong to YANG QI deficiency；It is tired, weak, belong to the deficiency of vital energy；It is general that giddy is bored, thick greasy fur belongs to phlegm wet Inner.Fasting process is carried out
Pathogenic analysis, after heat limitation, body is the warm body of yang-energy by cream fat (adipose tissue) change accumulated usually is enabled, but
Substantial amounts of lipid material can be generated during conversion.In theory of traditional Chinese medical science, lipid material is cream fat under physiological status, in disease
It is that phlegm is turbid under reason state.Phlegm is turbid not to be changed, and first cannot switch to the gentle warm body of sun, be second jammed mechanism of qi blood vessels.Thus may be used
See, the turbid Inner of phlegm is general not to be changed, and is that the interpretation of the cause, onset and process of an illness of fasting process is crucial..
The content of the invention
In order to mitigate the hunger of people under fasting state, the relevant side reaction of fasting is eliminated, the present invention provides one kind
Mitigate Chinese medicine of fasting or side reaction of dieting and preparation method thereof.The said preparation principles of formulating prescriptions and the pervious patent phase of the applicant
Seemingly, but medicament selection is entirely different, all by the Chinese medicine system of food and medicament dual-purpose, the prescription of doctor is not required, can exist as food
Market circulate, safety and can extensive use, curative for effect, no toxicity.
Department of Pharmacy applicant of the present invention carries out Syndrome Differentiation of Chinese Medicine according to the symptom occurred during fasting (or stringent diet control)
Card is understood, and then passes through the new Chinese medicine compound preparation of traditional Chinese medical science principle-method-recipe-medicines flow development.By the ginseng, fruit of Chinese wolfberry, arillus longan, white
Ten a herb such as hyacinth bean, jujube, Chinese cassia tree, fructus amomi, dried orange peel, Pogostemon cablin, sealwort, Radix Glycyrrhizae is prepared.Full side link closely fasting or
The interpretation of the cause, onset and process of an illness variation that diet occurs, all medicine compatibilities are reasonable, gather warming YANG and invigorating QI, the work(of clearing damp resolving sputum altogether.Available for fasting prevention it is overweight/
The pair occurred during the metabolic diseases such as fat and associated diabetes, hypertension, hyperlipidemia, fatty liver is anti-
It should.
Drug of the present invention is that acceptable excipient is prepared on bulk pharmaceutical chemicals and pharmacy by following weight parts：
Ginseng 1-3 fructus amomi 1-6 fruit of Chinese wolfberry 10-100 arillus longans 10-100
Semen Lablab Album 10-100 jujube 10-200 Chinese cassia tree 5-50 dried orange peels 5-50
Pogostemon cablin 10-200 sealwort 10-100 Radix Glycyrrhizaes 10-60
The turbid Inner of phlegm is general not to be changed, and is that the interpretation of the cause, onset and process of an illness of fasting process is crucial, so it is emphasis that warm resolving sputum is turbid.Full side is made a general survey of, ten simply
The pharmacological property that Chinese medicine has eight tastes belongs to warm nature, agrees with the interpretation of the cause, onset and process of an illness in the old maxim and feeding process of " sick phlegm and retained fluid person, when with warm medicine and it "
It is crucial.
Wrinkled giant hyssop acrid flavour, tepor can be with dampness elimination, relieving summer-heat, preventing or arresting vomiting；Fructus amomi acrid flavour, it is warm-natured, it can be with dampness elimination promoting the circulation of qi, middle benefit gas；Dried orange peel
Acrid flavour, hardship, it is warm-natured, it can be eliminating dampness and eliminating phlegm；More than three herbal medicines the effect of direct at that phlegm is turbid not to be changed sick and crucial, be altogether monarch drug in a prescription.
Chinese cassia tree acrid flavour, sweet, property heat, mends fire supporing yang, eliminating cold to stop pain, warming meridian in side；Arillus longan is sweet in flavor, warm-natured, can with tonifying heart and spleen,
Nourishing blood and tranquilization；Jujube is sweet in flavor, warm-natured, can be with tonifying middle-Jiao and Qi, nourishing blood and tranquilization, mitigation pharmacological property.This three taste, warming YANG and invigorating QI assist phlegm
Turbid temperature, ministerial drug.Ginseng is sweet in flavor, slight bitter, mild-natured, return lung, spleen, the heart channel of Hang-Shaoyin, can reinforce vital energy, reinforce the spleen to benefit the lung, promoting the production of body fluid, benefit of calming the nerves
Intelligence；Semen Lablab Album is sweet in flavor, slightly warm in nature, can be with tonifying spleen and middle dampness elimination；Sealwort is sweet in flavor, mild-natured, can be with boosting qi and nourishing yin, invigorating the spleen, moistening lung, benefit
Kidney；The fruit of Chinese wolfberry is sweet in flavor, mild-natured, can nourishing liver and kidney, benefiting shrewd head.This four taste mends profit parallel, is for adjutant.Radix Glycyrrhizae is sweet in flavor, property
It is flat, it can invigorate the spleen and benefit qi, relieving spasm to stop pain, can be to make medicine with coordinating the drug actions of a prescription.
Chinese cassia tree, arillus longan, jujube can yang-tonic tongmai, wet dampness elimination, in addition to aversion to cold and cold limbs symptom is released, can also help phlegm turbidity
Solution.Ginseng, Semen Lablab Album, Radix Glycyrrhizae tonifying Qi improve lassitude and weak.The warm and humid resolving sputum of fructus amomi, dried orange peel, wrinkled giant hyssop is dispelled turbid, and is phlegm with qi-regulating
Turbidity solution is opened a way.Sealwort, the fruit of Chinese wolfberry can seek sun by tonifying yin, can not only make full side warm but not dry, but also can make the fountainhead of yang-energy
It is inexhaustible.In addition, person sweet in flavor is more in side, Gan Zhehuan can alleviate the various side reactions occurred during fasting, make fasting process
It is steady smooth.
The weight of above-mentioned raw materials medicine is preferred：
3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry, 100 arillus longan 100
100 jujube of Semen Lablab Album, 200 Chinese cassia tree, 50 dried orange peel 50
200 sealwort of Pogostemon cablin, 100 Radix Glycyrrhizae 60
The weight of above-mentioned raw materials medicine is further preferably：
1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 15 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10
The weight of above-mentioned raw materials medicine is further preferably：
1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry, 60 arillus longan 60
60 jujube of Semen Lablab Album, 150 Chinese cassia tree, 30 dried orange peel 60
200 sealwort of Pogostemon cablin, 60 Radix Glycyrrhizae 30
The weight of above-mentioned raw materials medicine is further preferably：
2 fructus amomi of ginseng, 3 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 10 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10
The weight of above-mentioned raw materials medicine is further preferably：
3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 10 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10
Drug of the present invention can be prepared into acceptable oral formulations in any pharmacy according to the common process of this field
Dosage form.Wherein preferred powder, oral liquid, tablet, the water-bindered pill, honeyed bolus, capsule.
The powder of the present invention can be prepared as follows method and be made：
By the bulk pharmaceutical chemicals separate or merge add water to cook twice, for the first time plus 5-10 times of water measure, boil 1.5-3 it is small when,
Collect volatile oil；Second plus 4-8 times of water measure, boil 0.5-1.5 it is small when, collect volatile oil.Collecting decoction, filtering, by filtrate
Proportion is concentrated into 60 DEG C as 1.10-1.35, concentrate is released, is diluted with water, when standing 24 is small, supernatant is taken to cross 300-400
Day strainer, concentration, is mixed into the volatile oil of collection, adds appropriate excipient, be spray dried to particle；Pouch is distributed into get powder.
Other preferred dosage forms of the present invention can also be prepared as follows method and be made：
By the bulk pharmaceutical chemicals separate or merge add water to cook twice, for the first time plus 5-10 times of water measure, boil 1.5-3 it is small when,
Collect volatile oil；Second plus 4-8 times of water measure, boil 0.5-1.5 it is small when, collect volatile oil.Collecting decoction, filtering, by filtrate
Proportion is concentrated into 60 DEG C as 1.10-1.35, concentrate is released, is diluted with water, when standing 24 is small, supernatant is taken to cross 300-400
Day strainer, concentration, is mixed into the volatile oil of collection, then routinely oral liquid, tablet, the water answered ability day is respectively prepared in preparation process
Ball, honeyed bolus or capsule.
Beneficial effects of the present invention：The medication combined fasting of the present invention has metabolic syndrome good therapeutic effect, and
Without obvious adverse reaction；The ability of the resistance to starvation of patient can be greatly improved and receive the compliance of diet control.
Description of the drawings
Fig. 1 is that the severity felt corresponds to corresponding score axis.
Specific embodiment
The clinical observation of drug therapy weekend fasting in two days of the present invention
Clinically 33 weekend fasting patients of observed drug of the present invention, are overweight/obesity person.33 patients adhere to
Hunger after this preparation, aversion to cold and cold limbs, lassitude and weak, dizzy self sense such as bored are taken in the weekend fasting of surrounding during fasting
Feel that symptom is commented to be decreased obviously, weight is also decreased obviously, the results showed that the side reaction adjoint to fasting of this drug has apparent slow
Solution acts on, and patient is enable to adhere to 0 heat or extremely low heat two days or more, and can lose weight, and hypoglycemia is had no during use
Reaction and other adverse reactions.
(1) overweight and (or) fat diagnostic criteria：BMI≥25kg/m2；
(2) case inclusion criteria
1. meet the diagnostic criteria of overweight/obesity.
2. between age 18-70 Sui.
(3) case exclusion criteria
1. the age is in under-18s or the patient of 70 years old or more；
2. have in nearly 1 month Diabetic Acute complications (including diabetic Hypoglycemia, diabetic hyperosmolar coma,
Diabetic ketosis and ketoacidosis, diabetic lactoacidosis, Diabetic Acute infection)；
3. merge severe cardiac, the infull patient of Liver and kidney function；
4. mental disease fails partner；
5. gestation or nursing period and preparation gravid woman；
6. loner (refer to cannot coordinate fasting or Chinese medicine cannot be taken by regulation and the person of affecting the treatment；
7. malignant tumour and inpatient with haematological diseases；
8. active tuberculosis patient；
9. the ulcers of serious helmet bleeding；
10.1 diabetes mellitus types；
The control of 11.2 patients with type Ⅰ DM is bad, it is necessary to insulin injection patient；
12. the control of essential hypertension enalapril meleate is not waitd upon, secondary hypertension patient；
13. researcher is deemed unsuitable for enrolled other situations.
(4) all patients of therapy sign informed consent form before treatment is started, if there is high blood pressure, sugar are resistance to
Exception/New-Onset Diabetes Mellitus, dyslipidemia are measured on the basis of former treatment is maintained, weekend fasting is carried out and adds this Chinese medicine, the course for the treatment of
Four weekends.
(5) observation index
1. curative effect index：Hunger before and after this preparation, aversion to cold and cold limbs, lassitude and weak, dizzy bored etc. is taken during fasting
Feel symptom score, before fasting and surrounding fasting at the end of changes of weight.
2. safety indexes：Hypoglycemic incidence, curative compliance, hepatic and renal function, blood routine.
(6) Comprehensive Clinical the standard of curative effect evaluation
Feel the scoring that ten grades are carried out according to 0-9 point, it is hunger, aversion to cold and cold limbs, lassitude and weak, dizzy bored etc.
No
The suitable severity correspondence felt is scored accordingly, as shown in Figure 1,0 point is no any discomfort sense, 9 points
For not tolerable sense of discomfort, feed food is carried out to alleviate.
Curative effect judges
It is 1. effective：Symptom is felt during fasting and declines 3 points or more, after fasting in 4 weeks than expected severity
3.5 kilograms of weight loss or more.
2. effectively：Relatively expected 1 point or more of the decline of symptom is felt during fasting, weight loss 2 is public after fasting in 4 weeks
Jin or more.
It is 3. invalid：More than standard person is not achieved.
It is it is recommended that as follows：
(7) result
1. feel symptom variation (one)
Hunger lassitude and weak
Before taking medicine before number of cases medication after medication after medication
33 7.31±1.23 3.04±0.82 6.57±1.21 2.14±0.52
Patient is present with apparent hunger and lassitude and weak symptom during fasting, and scoring is higher before taking medicine, and takes this
It is decreased obviously after preparation, reaches significant levels.
2. feel symptom variation (two)
Aversion to cold and cold limbs giddy is bored
Before taking medicine before number of cases medication after medication after medication
33 4.28±0.53 1.33±0.23 7.33±1.22 2.14±0.55
Patient is present with apparent aversion to cold and cold limbs and dizzy bored symptom during fasting, and scoring is higher before taking medicine, and takes
It is decreased obviously after this preparation.
3. changes of weight (kilogram)
Before number of cases treatment after treatment
33 82.3±7.9 78.4±6.5
For patient before and after fasting, changes of weight is apparent.
5. Evaluation of Synthetic Effect of Holistic
Clinically drug of the present invention is used for weekend fasting, observes 33 overweight/obesity patients, wherein effective 28, have
Effect 5, invalid 0.
6. safety evaluatio
B ultrasound, which prompts 21, in 33 overweight/obesity patients different degrees of fatty liver, wherein 12 are being treated for the first time
Transaminase index rises during treatment, and more than normal range (NR), but without clinical meaning, transaminase is down to originally after recovering diet
It is below horizontal.Renal function index and blood routine examination no abnormality seen.
33 patients are without apparent hunger, equal finished chemoradiotherapy, and compliance is good.
(8) conclusion
The medication combined fasting of the present invention has good therapeutic effect to metabolic syndrome, and without obvious adverse reaction；It can
With the compliance for the ability of the resistance to starvation of patient being greatly improved He receiving diet control.
Embodiment 1
0.1 fructus amomi of ginseng, 0.1 fruit of Chinese wolfberry, 6 arillus longan 6
6 jujube of Semen Lablab Album, 15 Chinese cassia tree, 3 dried orange peel 3
9 sealwort of Pogostemon cablin, 6 Radix Glycyrrhizae 6
Routinely powder of the present invention is made in formulation method.
Embodiment 2
1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 15 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10
Oral liquid of the present invention is made according to a conventional method.
Embodiment 3
1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry, 60 arillus longan 60
60 jujube of Semen Lablab Album, 150 Chinese cassia tree, 30 dried orange peel 60
200 sealwort of Pogostemon cablin, 60 Radix Glycyrrhizae 60
Tablets are made according to a conventional method.
Embodiment 4
2 fructus amomi of ginseng, 3 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 10 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10
The water-bindered pill of the present invention is made according to a conventional method.
Embodiment 5
3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 10 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10
Honeyed bolus of the present invention is made according to a conventional method.
Embodiment 6
3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry, 100 arillus longan 100
100 jujube of Semen Lablab Album, 200 Chinese cassia tree, 50 dried orange peel 50
200 sealwort of Pogostemon cablin, 100 Radix Glycyrrhizae 100
Capsule of the present invention is made according to a conventional method.
Claims (6)
1. it is a kind of mitigate fasting or diet side reaction Chinese medicine, it is characterised in that it be by following weight parts proportioning bulk pharmaceutical chemicals with
Acceptable excipient is prepared in pharmacy：
Ginseng 1-3 fructus amomi 1-6 fruit of Chinese wolfberry 10-100 arillus longans 10-100
Semen Lablab Album 10-100 jujube 10-200 Chinese cassia tree 5-50 dried orange peels 5-50
Pogostemon cablin 10-200 sealwort 10-100 Radix Glycyrrhizaes 10-60.
2. Chinese medicine according to claim 1, it is characterised in that the parts by weight of bulk pharmaceutical chemicals are：
3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry, 100 arillus longan 100
100 jujube of Semen Lablab Album, 200 Chinese cassia tree, 50 dried orange peel 50
200 sealwort of Pogostemon cablin, 100 Radix Glycyrrhizae 60.
3. Chinese medicine according to claim 1, it is characterised in that the parts by weight of bulk pharmaceutical chemicals are：
1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 15 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10.
4. Chinese medicine according to claim 1, it is characterised in that the parts by weight of bulk pharmaceutical chemicals are：
2 fructus amomi of ginseng, 3 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 10 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10.
5. Chinese medicine according to claim 1, it is characterised in that the parts by weight of bulk pharmaceutical chemicals are：
3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry, 10 arillus longan 10
10 jujube of Semen Lablab Album, 10 Chinese cassia tree, 5 dried orange peel 5
10 sealwort of Pogostemon cablin, 10 Radix Glycyrrhizae 10.
6. according to claim 1-5 any one of them Chinese medicines, it is characterised in that：The Chinese medicine is powder, oral liquid, tablet, water
Ball, honeyed bolus or capsule.
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