CN106729304A - A kind of Chinese medicine for mitigating fasting or side reaction of going on a diet and preparation method thereof - Google Patents

A kind of Chinese medicine for mitigating fasting or side reaction of going on a diet and preparation method thereof Download PDF

Info

Publication number
CN106729304A
CN106729304A CN201611115616.9A CN201611115616A CN106729304A CN 106729304 A CN106729304 A CN 106729304A CN 201611115616 A CN201611115616 A CN 201611115616A CN 106729304 A CN106729304 A CN 106729304A
Authority
CN
China
Prior art keywords
chinese
fasting
chinese medicine
sealwort
fruit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201611115616.9A
Other languages
Chinese (zh)
Other versions
CN106729304B (en
Inventor
秦朗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qin Jian
Original Assignee
秦朗
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 秦朗 filed Critical 秦朗
Priority to CN201611115616.9A priority Critical patent/CN106729304B/en
Publication of CN106729304A publication Critical patent/CN106729304A/en
Application granted granted Critical
Publication of CN106729304B publication Critical patent/CN106729304B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/77Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9064Amomum, e.g. round cardamom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a kind of Chinese medicine for mitigating fasting or side reaction of going on a diet and preparation method thereof.Said preparation composition is ginseng, the fruit of Chinese wolfberry, arillus longan, Semen Lablab Album, date, Chinese cassia tree, fructus amomi, dried orange peel, Pogostemon cablin, sealwort, Radix Glycyrrhizae.Full side links closely the interpretation of the cause, onset and process of an illness change under fasting state, all medicine reasonable compatibilities, gather altogether Wen Yang, tonifying Qi, change turbid, replenishing essence work(.Receive hunger and other side reactions that the crowd of fasting is likely to occur in the fasted state for mitigating.Preliminary clinical test shows that inventive formulation definite effect, effect is rapid, without toxicity, can receive fasting crowd resistance to hungry ability and compliance with significant increase.

Description

A kind of Chinese medicine for mitigating fasting or side reaction of going on a diet and preparation method thereof
Technical field
The present invention relates to medicine preparation and heat limitation field, more particularly, in a kind of mitigation fasting or side reaction of going on a diet Medicine and preparation method thereof.
Background technology
Medically described fasting, it is daily zero by the heat of alimentary canal dietary intake to refer to.But as a kind of health care Method, the definition of fasting is more wide in range, has with the definition of very low calorie diet and intersects, and refers to the heat taken in from alimentary canal daily Less than 200-400 kilocalories, so following fasting includes very low calorie diet.
Fasting has been carried out more than 100 years as a kind of health care therapeutic method in Europe, can treat fatty liver, blood high Pressure disease, blood fat disorder, fat and overweight, diabetes B, OSAS, metabolic syndrome;Rheumatism joint Inflammation, psoriasis, allergy, allergic rhinitis;Constipation, enterogastric diseases, IBS;Osteoarthritis, tendon disease, back Bitterly;Asthma, flu, influenza, bronchitis;Candidiasis, headache, menopausal syndrome, smoking, excessive drinking, acne;Etc..
Appropriate fasting can find evidence in the above-mentioned disease of clinical treatment from many laboratory researches, its mechanism bag Autophagy is included, is suppressed inflammatory factor, anti-oxidant, stem cell regenerating, is immunized and restarts, suppress TGF, improve cognitive function, Etc..
Fasting not Europe original creation, just has " warding off paddy " health preserving method, from road in the epoch China in even more time immemorial " not eating five cereals " in family's health, is a kind of Curing Method that ancients commonly use.It starts from the pre-Qin days, is popular in the Tang Dynasty, also known as but paddy, Go paddy, exhausted paddy, go without food, but grain, stop grain etc..
The earliest record of paddy is warded off to be derived from《The carefree trip of village》:" here the mountain that small aunt penetrates has extraordinary person residence.If skin ice and snow, mire If about virgin, does not eat five cereals, inhale wind and drink dew, multiply thin clouds, drive flying dragon, and swim outside the four seas ... " as a kind of macrobiosis benefit The health rule in longevity, wards off paddy also on the books in many ancient book ancient books and records.For example,《Wash you》Have " deficiency of food and it is convinced, be that must enjoy day Year " say;《Dadailiji easily this life》Say:" food meat person is brave and brave, eats paddy person wisdom and skilful, eats gas person gods and the longevity, no Trencherman is not extremely refreshing." illustrate that warding off paddy plays the role of to promote longevity.
After Taoism is founded, this art is followed, paddy person is warded off in cultivation, for not incapable persons.Record sweet wormwood application method《Preemergency after elbow Side》, its Taoist priest of author Ge Hongnai mono-,《Baopuzi neipian is miscellaneous should》Middle theory:" remainder is shown in that 2 years persons of disconnected paddy people three year are more, all The light color of body is good.”
Ancients have also spoken of the side reaction and its solution party for warding off paddy in addition to the health cultivation and rehabilitation positive effect that paddy is warded off in discovery Case.The unearthed Western Han Dynastry's book copied on silk in Changsha Mawangdui《(but) paddy is gone to eat gas》Cloud:" (but) paddy person is gone to eat pyrrosia lingua.Head weights, foot are light, body Sorrowful , Ze Xu (Xu) cooks a meal (blow) it, stops depending on profit." hunger phenomenon that top-heavy limbs fatigue is often produced when warding off paddy is meant, Solution has two aspects, and one is the pyrrosia lingua that takes traditional Chinese medicine, and one is to eat gas (convinced) with " blowing Xu ", i.e., soft slow elongated breath is received.
The convinced principle for warding off paddy is explained and is probably:Saliva, empty gas and water are by swallowing, correct Breathing Method, into alimentary canal It is interior, nutriment is synthesized in vivo, sustained life such that it is able to not eat five cereals for a long time.This method may look like psychology Hint mitigate hunger, it is but incompatible with modern scientific theory.
On using Chinese medicine,《Cloud book box seven is signed》Volume five is carried, and Sun You high mountains " are eaten art but grain, take paddy celestial being ball 67 years, face is color light Profit, essence is refreshing elegant clean." ward off the medicine that paddy takes, have glutinous rehmannia, sealwort, the fleece-flower root, the fruit of Chinese wolfberry, lucid asparagus, the tuber of dwarf lilyturf, chrysanthemum, Poria cocos, The bighead atractylodes rhizome, pine nut, cedar seed, the seed of jog's tears, Chinese yam, almond, the root of herbaceous peony, calamus, rhizoma alismatis, pyrrosia lingua etc..The Chinese medicine preparation five of each utilization spends eight Door, but to be the tcm symptom sign that occurs by patient during to fasting without one carry out the thinking of principle-method-recipe-medicines and distinguish Card is treated, and its effect leaves a question open.
At present in addition to applicant and Chen Dingsheng (the cooperation post-doctor of applicant), fasting side reaction is not almost directed to Chinese prescription invention.And my previous invention is made up of Chinese medicine, can only declare being made Chinese medicine preparation and exist by new drug Hospital circulates, it is impossible to be widely used as food.
According to the research of Chinese fasting treatment founder Qin Jian et al., fasting or go on a diet, can be gone out with similar to warding off paddy Existing side reaction:Limb is cold, chilly, tired, weak, dizzy vexed, the tongue is coated.The core of these side reactions is hunger, can be compeled The people that making fasting in need carries out health care are difficult to adhere to, or give up halfway.
We are analyzed and Dialectical thought by the tcm symptom occurred during to fasting, and the limb that fasting crowd occurs is cold, fear It is cold, belong to YANG QI deficiency;It is tired, weak, belong to the deficiency of vital energy;It is general that dizzy vexed, the tongue is coated belongs to phlegm wet Inner.Fasting process is carried out Pathogenic analysis, after heat limitation, body will enable the cream fat (adipose tissue) for accumulating usually and change and be the warm body of yang-energy, but Substantial amounts of lipid material can be produced during conversion.In theory of traditional Chinese medical science, lipid material is cream fat under physiological status, in disease Phlegm is under reason state turbid.Phlegm is turbid not to be changed, and first can not switch to the gentle warm body of sun, and be second jammed mechanism of qi blood vessels.Thus may be used See, the turbid Inner of phlegm is general not to be changed, be that the interpretation of the cause, onset and process of an illness of fasting process is crucial..
The content of the invention
In order to mitigate the hunger of people under fasting state, the related side reaction of fasting is eliminated, the invention provides one kind Mitigate Chinese medicine of fasting or side reaction of going on a diet and preparation method thereof.Patent phase before the said preparation principles of formulating prescriptions and the applicant Seemingly, but medicament selection is entirely different, all by the Chinese medicine system of food and medicament dual-purpose, it is not necessary to the prescription of doctor, can exist as food Market circulate, safety and can extensive use, determined curative effect, without toxicity.
Department of Pharmacy applicant of the present invention carries out Syndrome Differentiation of Chinese Medicine according to the symptom occurred during fasting (or strict diet control) Card is understood, and then the new Chinese medicine compound preparation developed by traditional Chinese medical science principle-method-recipe-medicines flow.By the ginseng, fruit of Chinese wolfberry, arillus longan, white The a herb of French beans, date, Chinese cassia tree, fructus amomi, dried orange peel, Pogostemon cablin, sealwort, Radix Glycyrrhizae etc. ten is prepared from.Full side link closely fasting or Go on a diet the interpretation of the cause, onset and process of an illness change of appearance, all medicine compatibilities rationally, gather warming YANG and invigorating QI, the work(of clearing damp resolving sputum altogether.Can be used for fasting preventing and treating it is overweight/ The pair occurred during the metabolic diseases such as fat and associated diabetes, hypertension, hyperlipidemia, fatty liver is anti- Should.
Medicine of the present invention is that acceptable excipient is prepared from bulk drug and pharmacy by following weight parts:
Ginseng 1-3 fructus amomi 1-6 fruit of Chinese wolfberry 10-100 arillus longans 10-100
Semen Lablab Album 10-100 date 10-200 Chinese cassia tree 5-50 dried orange peels 5-50
Pogostemon cablin 10-200 sealwort 10-100 Radix Glycyrrhizaes 10-60
The turbid Inner of phlegm is general not to be changed, and is that the interpretation of the cause, onset and process of an illness of fasting process is crucial, so it is emphasis that warm resolving sputum is turbid.Full side is made a general survey of, ten simply The property of medicine that Chinese medicine has eight tastes belongs to warm nature, agree with " sick phlegm and retained fluid person, when with warm medicine and it " old maxim and feeding process in the interpretation of the cause, onset and process of an illness It is crucial.
Wrinkled giant hyssop taste is pungent, tepor can be with dampness elimination, relieving summer-heat, preventing or arresting vomiting;Fructus amomi taste is pungent, it is warm in nature, can be with dampness elimination promoting the circulation of qi, middle benefit gas;Dried orange peel Taste is pungent, hardship, it is warm in nature, can be with eliminating dampness and eliminating phlegm;Effect of the herbal medicine of the above three directs at the turbid sick and key do not changed of phlegm, is altogether monarch drug in a prescription. Chinese cassia tree taste is pungent, sweet, property heat, mends fire supporing yang, eliminating cold to stop pain, warming meridian in side;Arillus longan is sweet, warm in nature, can with tonifying heart and spleen, Nourishing blood and tranquilization;Date is sweet, warm in nature, can be with tonifying middle-Jiao and Qi, nourishing blood and tranquilization, the mitigation property of medicine.This three taste, warming YANG and invigorating QI assists phlegm Turbid temperature, ministerial drug.Ginseng is sweet, slight bitter, mild-natured, return lung, spleen, the heart channel of Hang-Shaoyin, can reinforce vital energy, reinforce the spleen to benefit the lung, promoting the production of body fluid, benefit of calming the nerves Intelligence;Semen Lablab Album is sweet, slightly warm in nature, can be with tonifying spleen and middle dampness elimination;Sealwort is sweet, mild-natured, can be with boosting qi and nourishing yin, invigorating the spleen, moistening lung, benefit Kidney;The fruit of Chinese wolfberry is sweet, mild-natured, can be with nourishing liver and kidney, benefiting shrewd head.This four taste, mends profit parallel, and it is adjutant to be.Radix Glycyrrhizae is sweet, property It is flat, can invigorate the spleen and benefit qi, relieving spasm to stop pain, can be to make medicine with coordinating the drug actions of a prescription.
Chinese cassia tree, arillus longan, date can yang-tonic tongmai, wet dampness elimination, except release aversion to cold and cold limbs symptom in addition to, can also help phlegm turbidity Solution.Ginseng, Semen Lablab Album, Radix Glycyrrhizae tonifying Qi, improve lassitude and weak.The warm and humid resolving sputum of fructus amomi, dried orange peel, wrinkled giant hyssop is dispelled turbid, is phlegm and with qi-regulating Turbidity solution is opened a way.Sealwort, the fruit of Chinese wolfberry can seek sun by tonifying yin, can both make full side warm but not dry, and the fountainhead of yang-energy can be made again It is inexhaustible.In addition, sweet person is more in side, Gan Zhehuan can alleviate the various side reactions occurred during fasting, make fasting process It is steady smooth.
The weight of above-mentioned raw materials medicine is preferred:
The arillus longan 100 of 3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry 100
The dried orange peel 50 of 100 date of Semen Lablab Album, 200 Chinese cassia tree 50
The Radix Glycyrrhizae 60 of 200 sealwort of Pogostemon cablin 100
The weight of above-mentioned raw materials medicine is further preferably:
The arillus longan 10 of 1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 15 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10
The weight of above-mentioned raw materials medicine is further preferably:
The arillus longan 60 of 1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry 60
The dried orange peel 60 of 60 date of Semen Lablab Album, 150 Chinese cassia tree 30
The Radix Glycyrrhizae 30 of 200 sealwort of Pogostemon cablin 60
The weight of above-mentioned raw materials medicine is further preferably:
The arillus longan 10 of 2 fructus amomi of ginseng, 3 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 10 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10
The weight of above-mentioned raw materials medicine is further preferably:
The arillus longan 10 of 3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 10 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10
Medicine of the present invention can be prepared into acceptable oral formulations in any pharmacy according to the common process of this area Formulation.Wherein preferred powder, oral liquid, tablet, the water-bindered pill, honeyed bolus, capsule.
Powder of the invention can be prepared as follows method and be made:
The bulk drug is separated or merging is added water to cook twice, added water for the first time 5-10 times and measure, boiled 1.5-3 hours, Collect volatile oil;Add water for the second time 4-8 times and measure, boil 0.5-1.5 hours, collect volatile oil.Collecting decoction, filtering, by filtrate Proportion is concentrated into 60 DEG C for 1.10-1.35, concentrate is released, is diluted with water, stand 24 hours, taken supernatant and cross 300-400 Day filter screen, concentration is mixed into the volatile oil of collection, plus appropriate excipient, is spray dried to particle;Pouch is distributed into, powder is obtained final product.
Other preferred dosage forms of the invention can also be prepared as follows method and be made:
The bulk drug is separated or merging is added water to cook twice, added water for the first time 5-10 times and measure, boiled 1.5-3 hours, Collect volatile oil;Add water for the second time 4-8 times and measure, boil 0.5-1.5 hours, collect volatile oil.Collecting decoction, filtering, by filtrate Proportion is concentrated into 60 DEG C for 1.10-1.35, concentrate is released, is diluted with water, stand 24 hours, taken supernatant and cross 300-400 Day filter screen, concentration, is mixed into the volatile oil of collection, and then routinely preparation process is respectively prepared oral liquid, tablet, the water answered ability day Ball, honeyed bolus or capsule.
Beneficial effects of the present invention:The medication combined fasting of the present invention has good therapeutic effect to metabolic syndrome, and Without obvious adverse reaction;The resistance to hungry ability of patient can be greatly improved and receives the compliance of diet control.
Brief description of the drawings
Fig. 1 is the corresponding score axis of order of severity correspondence for feeling.
Specific embodiment
The clinical observation of fasting of two days drug therapy weekends of the present invention
Clinically 33 weekend fasting patientses of observed drug of the present invention, are overweight/obesity person.33 patients adhere to The weekend fasting of surrounding, takes hunger after this preparation, aversion to cold and cold limbs, lassitude and weak, dizzy self sense such as vexed during fasting Feel that symptom is commented to be decreased obviously, body weight is also decreased obviously, as a result show that the side reaction adjoint to fasting of this medicine has obvious slow Solution is acted on, and patient is adhered to 0 heat or extremely low heat more than two days, and can be lost weight, and hypoglycemia is had no during use Reaction and other adverse reactions.
(1) overweight and (or) fat diagnostic criteria:BMI≥25kg/m2;
(2) case inclusive criteria
1. the diagnostic criteria of overweight/obesity is met.
2. between age 18-70 Sui.
(3) case exclusion standard
1. the age is in under-18s or the patient of more than 70 years old;
2. have in nearly 1 month Diabetic Acute complications (including diabetic Hypoglycemia, diabetic hyperosmolar coma,
Diabetic ketosis and DKA, diabetic lactoacidosis, Diabetic Acute infection);
3. severe cardiac, the infull patient of Liver and kidney function are merged;
4. mental disease fails partner;
5. gestation or nursing period and prepare gravid woman;
6. loner (referring to can not coordinate fasting or can not take Chinese medicine and the person of affecting the treatment by regulation;
7. malignant tumour and inpatient with haematological diseases;
8. active tuberculosis patient;
9. ulcers of serious helmet bleeding;
10.1 diabetes mellitus types;
The control of 11.2 patients with type Ⅰ DM is bad, it is necessary to insulin injection patient;
The control of 12. essential hypertension enalapril meleates is not waitd upon, secondary hypertension patient;
13. researchers are deemed unsuitable for enrolled other situations.
(4) all patients for the treatment of method sign Informed Consent Form before treatment is started, if high blood pressure, sugar are resistance to Amount exception/New-Onset Diabetes Mellitus, dyslipidemia carry out weekend fasting and add this Chinese medicine, the course for the treatment of on the basis of former treatment is maintained Four weekends.
(5) observation index
1. curative effect index:Hunger before and after this preparation, aversion to cold and cold limbs, lassitude and weak, dizzy vexed etc. is taken during fasting Feel symptom score, before fasting and surrounding fasting at the end of changes of weight.
2. safety indexes:Hypoglycemic incidence, curative compliance, hepatic and renal function, blood routine.
(6) Comprehensive Clinical the standard of curative effect evaluation
Feel to divide according to 0-9 and carry out ten scorings of grade, hunger, aversion to cold and cold limbs, lassitude and weak, giddy are vexed etc. No
The suitable order of severity correspondence for feeling is scored accordingly, as shown in figure 1,0 point is no any discomfort sense, 9 points It is not tolerable sense of discomfort, carries out feed food to alleviate.
Outcome measure
1. effective:Symptom is felt during fasting and declines more than 3 points, after fasting in 4 weeks terminates than the expected order of severity More than 3.5 kilograms of Body weight loss.
2. effective:Feel symptom during fasting to be relatively expected to decline more than 1 point, it is public that fasting in 4 weeks terminates rear Body weight loss 2 It is more than jin.
3. invalid:Above standard person is not reached.
Suggestion is as follows:
(7) result
1. symptom change () is felt
Hunger lassitude and weak
Before number of cases medication after medication after the preceding medication of medication
337.31±1.233.04±0.826.57±1.212.14±0.52
Patient occurs obvious hunger and lassitude and weak symptom during fasting, and scoring is higher before medication, takes this It is decreased obviously after preparation, reaches significant levels.
2. symptom change (two) is felt
Aversion to cold and cold limbs giddy is vexed
Before number of cases medication after medication after the preceding medication of medication
334.28±0.531.33±0.237.33±1.222.14±0.55
Patient occurs obvious aversion to cold and cold limbs and dizzy vexed symptom during fasting, and scoring is higher before medication, takes It is decreased obviously after this preparation.
3. changes of weight (kilogram)
Before number of cases treatment after treatment
3382.3±7.978.4±6.5
Patient is before and after fasting, and changes of weight is obvious.
5. Evaluation of Synthetic Effect of Holistic
Clinically medicine of the present invention is used for weekend fasting, observes 33 overweight/obesity patients, wherein effective 28, have Effect 5, invalid 0.
6. safety evaluatio
B ultrasonic points out 21 in 33 overweight/obesity patients different degrees of fatty liver, wherein 12 in treatment first time Transaminase index rises during treatment, and more than normal range (NR), but without clinical meaning, transaminase is down to originally after recovering diet It is below horizontal.Renal function index and blood routine examination no abnormality seen.
33 patients are without obvious hunger, and equal finished chemoradiotherapy, compliance is good.
(8) conclusion
The medication combined fasting of the present invention has good therapeutic effect to metabolic syndrome, and without obvious adverse reaction;Can
With the compliance for the resistance to hungry ability of patient being greatly improved and receiving diet control.
Embodiment 1
The arillus longan 6 of 0.1 fructus amomi of ginseng, 0.1 fruit of Chinese wolfberry 6
The dried orange peel 3 of 6 date of Semen Lablab Album, 15 Chinese cassia tree 3
The Radix Glycyrrhizae 6 of 9 sealwort of Pogostemon cablin 6
Routinely formulation method is made powder of the present invention.
Embodiment 2
The arillus longan 10 of 1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 15 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10
Oral liquid of the present invention is made according to a conventional method.
Embodiment 3
The arillus longan 60 of 1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry 60
The dried orange peel 60 of 60 date of Semen Lablab Album, 150 Chinese cassia tree 30
The Radix Glycyrrhizae 60 of 200 sealwort of Pogostemon cablin 60
Tablets are made according to a conventional method.
Embodiment 4
The arillus longan 10 of 2 fructus amomi of ginseng, 3 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 10 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10
The water-bindered pill of the present invention is made according to a conventional method.
Embodiment 5
The arillus longan 10 of 3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 10 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10
Honeyed bolus of the present invention is made according to a conventional method.
Embodiment 6
The arillus longan 100 of 3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry 100
The dried orange peel 50 of 100 date of Semen Lablab Album, 200 Chinese cassia tree 50
The Radix Glycyrrhizae 100 of 200 sealwort of Pogostemon cablin 100
Capsule of the present invention is made according to a conventional method.

Claims (9)

1. a kind of Chinese medicine preparation for mitigating fasting or side reaction of going on a diet, it is characterised in that it is the raw material matched by following weight parts Medicine is prepared from acceptable excipient in pharmacy:
Ginseng 1-3 fructus amomi 1-6 fruit of Chinese wolfberry 10-100 arillus longans 10-100
Semen Lablab Album 10-100 date 10-200 Chinese cassia tree 5-50 dried orange peels 5-50
Pogostemon cablin 10-200 sealwort 10-100 Radix Glycyrrhizaes 10-60.
2. Chinese medicine according to claim 1, it is characterised in that part of measuring again of bulk drug is:
The arillus longan 100 of 3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry 100
The dried orange peel 50 of 100 date of Semen Lablab Album, 200 Chinese cassia tree 50
The Radix Glycyrrhizae 60 of 200 sealwort of Pogostemon cablin 100.
3. Chinese medicine according to claim 1, it is characterised in that the weight portion of bulk drug is:
The arillus longan 10 of 1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 15 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10.
4. Chinese medicine according to claim 1, its feature, the weight portion for being bulk drug is:
The arillus longan 60 of 1 fructus amomi of ginseng, 1 fruit of Chinese wolfberry 60
The dried orange peel 60 of 60 date of Semen Lablab Album, 150 Chinese cassia tree 30
The Radix Glycyrrhizae 30 of 200 sealwort of Pogostemon cablin 60.
5. Chinese medicine according to claim 1, it is characterised in that the weight portion of bulk drug is:
The arillus longan 10 of 2 fructus amomi of ginseng, 3 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 10 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10.
6. Chinese medicine according to claim 1, it is characterised in that the weight portion of bulk drug is:
The arillus longan 10 of 3 fructus amomi of ginseng, 6 fruit of Chinese wolfberry 10
The dried orange peel 5 of 10 date of Semen Lablab Album, 10 Chinese cassia tree 5
The Radix Glycyrrhizae 10 of 10 sealwort of Pogostemon cablin 10.
7. the Chinese medicine according to claim any one of 1-6, it is characterised in that:The Chinese medicine is powder, oral liquid, tablet, water Ball, honeyed bolus or capsule.
8. the preparation method of Chinese medicine according to claim 7, it is characterised in that comprise the following steps:
The bulk drug is separated or merging is added water to cook twice, added water for the first time 5-10 times and measure, boiled 1.5-3 hours, collected Volatile oil;Add water for the second time 4-8 times and measure, boil 0.5-1.5 hours, collect volatile oil;Collecting decoction, filtering, by filtrate in 60 Proportion DEG C is concentrated into for 1.10-1.35, concentrate is released, is diluted with water, stand 24 hours, taken supernatant and cross filter in 300-400 days Net, concentration is mixed into the volatile oil of collection, plus appropriate excipient, is spray dried to particle;Pouch is distributed into, powder is obtained final product.
9. the preparation method of Chinese medicine according to claim 7, it is characterised in that comprise the following steps:
The bulk drug is separated or merging is added water to cook twice, added water for the first time 5-10 times and measure, boiled 1.5-3 hours, collected Volatile oil;Add water for the second time 4-8 times and measure, boil 0.5-1.5 hours, collect volatile oil;Collecting decoction, filtering, by filtrate in 60 Proportion DEG C is concentrated into for 1.10-1.35, concentrate is released, is diluted with water, stand 24 hours, taken supernatant and cross filter in 300-400 days Net, concentration, be mixed into the volatile oil of collection, then routinely preparation process be respectively prepared answer ability day oral liquid, tablet, the water-bindered pill, Honeyed bolus or capsule.
CN201611115616.9A 2016-12-07 2016-12-07 A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof Active CN106729304B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611115616.9A CN106729304B (en) 2016-12-07 2016-12-07 A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611115616.9A CN106729304B (en) 2016-12-07 2016-12-07 A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof

Publications (2)

Publication Number Publication Date
CN106729304A true CN106729304A (en) 2017-05-31
CN106729304B CN106729304B (en) 2018-05-22

Family

ID=58877015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201611115616.9A Active CN106729304B (en) 2016-12-07 2016-12-07 A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106729304B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111184814A (en) * 2020-03-25 2020-05-22 明昌平 A Chinese medicinal composition for treating obesity and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101073408A (en) * 2007-06-15 2007-11-21 刘志钊 Nourishing Yuan and removing Gu pills

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101073408A (en) * 2007-06-15 2007-11-21 刘志钊 Nourishing Yuan and removing Gu pills

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
梁润英: ""《千金翼方》辟谷养生方药探析"", 《中医文献杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111184814A (en) * 2020-03-25 2020-05-22 明昌平 A Chinese medicinal composition for treating obesity and preparation method thereof

Also Published As

Publication number Publication date
CN106729304B (en) 2018-05-22

Similar Documents

Publication Publication Date Title
CN104509619B (en) A kind of Chinese medical health slimming tea and preparation method thereof
CN102028900B (en) Traditional Chinese medicine for treating metabolic syndrome and preparation method thereof
CN100435831C (en) Preparation for treating high blood pressure, high blood fat, obesity, and climacteric syndrome, and preparation method
CN101107995A (en) Traditional Chinese medicine health care beverage bag
CN102293273A (en) Health tea capable of adjusting blood pressure, blood sugar and blood fat and preventing thrombus and apoplexy
CN108524814A (en) A kind of Chinese medicine composition and preparation method thereof for reducing blood glucose
CN103445170A (en) Spleen-tonifying and stomach-nourishing powder
CN102113534B (en) Moon cake with function of treating diabetes and preparation method thereof
CN100493572C (en) Composition of medication for treating diabetes
CN102813870B (en) Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof
CN104208425B (en) A kind of Chinese medicine preparation for being used to nurse one's health critical hypertension
CN105395706A (en) Health care product for diabetes
CN102512591B (en) Composition with functions of losing weight and reducing blood glucose and lipid
CN106729304B (en) A kind of Chinese medicine for mitigating fasting or side reaction of dieting and preparation method thereof
CN107927781B (en) Traditional Chinese medicine weight-losing meal replacement
CN106913626B (en) A kind of pharmaceutical composition for treating enterogastritis and preparation method thereof, preparation and application
CN109528968A (en) A kind of Chinese medicine composition and its preparation method and application for treating diabetes B
CN101352552B (en) Capsules for promoting children's intelligence, growth and development
CN104189038B (en) Chinese medicine preparation for nursing one's health female pathology health and immunologic function
CN102048146A (en) Healthcare food with functions of beautifying, skin-care, yellow-removing, antiagingand preparation method thereof
CN105853505A (en) Qi-and-lung-tonifying healthcare medicine composition containing five-leaf gynostemma herb
CN102861223A (en) Seven-medicament diabetes treating capsule
CN108478739A (en) A kind of health products and preparation method thereof adjusting equilibrium between yin and yang
CN107596327A (en) A kind of medicine for treating intermingling cold and heat functional dyspepsia FD
CN100400090C (en) Medicine composition for treating myasthenia gravis and prepn. method therefor

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: Qin Lang

Inventor after: Qin Jian

Inventor before: Qin Lang

TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20180403

Address after: Room 1005, room 699, Dongfeng East Road, Guangzhou, Guangdong Province

Applicant after: Qin Lang

Applicant after: Qin Jian

Address before: Room 1005, room 699, Dongfeng East Road, Guangzhou, Guangdong Province

Applicant before: Qin Lang

GR01 Patent grant
GR01 Patent grant