CN106031414A - Konjak powdery particle, preparation method and applications thereof - Google Patents
Konjak powdery particle, preparation method and applications thereof Download PDFInfo
- Publication number
- CN106031414A CN106031414A CN201510106163.2A CN201510106163A CN106031414A CN 106031414 A CN106031414 A CN 106031414A CN 201510106163 A CN201510106163 A CN 201510106163A CN 106031414 A CN106031414 A CN 106031414A
- Authority
- CN
- China
- Prior art keywords
- rhizoma amorphophalli
- granule
- amorphophalli powder
- powder granule
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a konjak powdery particle, which comprises konjak powder and a solid adhesive. The konjak powdery particle does not contain any liquid adhesive, and the average diameter or diameter of the particle is 0.5 to 5 mm. The particle is user-friendly, and compliance is good. The provided particle can well stabilize the peak blood sugar content after dinner, can reduce blood sugar and blood fat, is capable of reducing the weight, is user-friendly, and is easy to carry. The invention also discloses a preparation method and applications of the konjak powdery particle.
Description
Technical field
The present invention relates to food technology field, particularly to a kind of Rhizoma amorphophalli powder granule and its production and use.
Background technology
Rhizoma amorphophalli (Amorphophallus Konjac C.Koch) is a kind of ancient Traditional health care food.In China, the history of plantation Rhizoma amorphophalli on the books away from modern more than 1700 year.Amorphophallus aroid, medicine-food two-purpose, its medical value, the most on the books in Compendium of Material Medica: " warm in nature, sweet in the mouth is pungent ", " cure mainly carbuncle pathogenic wind toxic ... main quench one's thirst (diabetes) ".Edible then mainly make gel food, such as Rhizoma amorphophalli bean curd etc..Rhizoma amorphophalli be mainly composed of glucomannoglycan (Konjac Glucomannan is referred to as KGM), be non-starch plant polysaccharide.It is by the molecular ratios of 1:1:6 by D-Glucose and D-MANNOSE, is polymerized with β-(1-4) glycosidic bond.Feature the most prominent for KGM is that molecular weight is very big, reaches 60-200 ten thousand dalton.The viscosity of industrial products, up to more than 20000mpa.s, is that in vegetable polysaccharides, viscosity is maximum " king of viscosity ".China's Rhizoma amorphophalli polish, deep processing originate from the eighties, progressive the fastest.At present the purification of Rhizoma amorphophalli powder, refinement, KGM separating-purifying in terms of met or exceeded the advanced level of Japan, can produce the Rhizoma amorphophalli powder highly become more meticulous.The content of KGM>90% (butt), granularity<120 mesh.
KGM is the excellent soluble cellulose that function is unique.Confirming according to more than 100 piece research reports published both at home and abroad found, KGM has following health care: 1, regulate blood glucose, particularly post-prandial glycemia；2, regulation blood fat, reduction cholesterol, suppression triglyceride raises, and removes fatty liver effect notable；3, satiety is obvious, is highly resistant to hunger, is substantially free of heat, is preferably to help control diet food；4, constipation relieving, prevents intestinal cancer；Additionally, it also has enhancing immunity, discharge the functions such as harmful heavy metal.KGM is neutral polysaccharide, is not combined with positively charged metallic, does not affect the absorption to trace element.In today of " rich man's disease " Outbreak, many research medical science of KGM, nutritionist are all advocated, and widely popularize universal KGM food fibres, to regulate nutritive equilibrium, reduce overnutrition healthhazard.Allow people eat KGM more, first it is considered that add in food by KGM, make fiber diet.But owing to KGM viscosity is too big, even if addition the lowest (such as 1%), also can change the edible quality of food, difficulty is the biggest.Mostly advocate individually to eat KGM as dietary fiber complementary goods both at home and abroad.
Further investigations have shown that, giving full play to of the above-mentioned health care of KGM is very big with its food form or dosage form relation, the most crucial.Japanese Scientists is pointed out, the performance of KGM physiologically active must keep its solubility (gel impact activity), and has sufficient moisture content, and KGM powder can be dispersed after entering stomach, fully imbibition, discharge viscosity to greatest extent, wrap up food, increase the viscosity of food paste, thus delay digestion process, reduce the digestion peak demand to insulin, reduce the small intestinal absorption to glucose with fat, effectively regulate blood glucose, blood fat.The food form of KGM dietary fiber complementary goods or dosage form, it is necessary to can meet KGM and play the prerequisite condition of physiologically active, this point is particularly important.
At present, on domestic and international market, one of Main Foods form of KGM dietary fiber complementary goods is Rhizoma amorphophalli powder, and owing to the performance of KGM physiologically active needs 2 conditions: (1) must keep its solubility, (2) are with the presence of sufficient moisture content.Problem is, when the two condition is provided simultaneously with, will Rhizoma amorphophalli powder when being poured into water, in whipping process, Rhizoma amorphophalli powder the most i.e. discharges viscosity and forms gel, more edible cannot food mixing in stomach function regulating, have impact on the performance of KGM effect.
Gel is formed owing to Rhizoma amorphophalli powder contact moisture content i.e. discharges viscosity, so Rhizoma amorphophalli powder cannot be pelletized (typically with certain density aquiferous ethanol or water in conventional method pelletization according to a conventional method, Rhizoma amorphophalli powder surface all can be made to form gel) and it is pressed into tablet, therefore on market, rarely have Rhizoma amorphophalli powder sheet previous generation, sell one of Main Foods form of KGM dietary fiber complementary goods on domestic and international market at present and also have capsule.The shortcoming of capsule is: after swallowing stomach, in capsule shells course of dissolution, moisture content can touch the Rhizoma amorphophalli powder of dress in capsule, Rhizoma amorphophalli powder one touches water, i.e. starting to discharge viscosity, now capsule shells is not yet dissolved, and sticking together of capsule shape formed by result Rhizoma amorphophalli powder, fully cannot contact with food, be unfavorable for giving full play to of KGM physiologically active.The shortcoming of tablet is: swallow dispersibility in stomach poor, and outer coating powder water suction is faster than internal layer, easily lumps after release viscosity, spawn is formed on its surface, cause internal layer powder fully not contact with water, it is difficult to dispersion, be also unfavorable for giving full play to of KGM physiologically active.
Based on problem above, inventor applied for konjaku flour dispersible tablet patent (patent No.: ZL200610020242.2) in 2006, disadvantage mentioned above has been had certain improvement, but find in actual production process, konjaku flour dispersible tablet is the strictest to the pressure requirements of tabletting, pressure is the biggest, there will be the problem the same with ordinary tablet, in water the most fully dispersed, outer coating powder surface i.e. forms gelling material, the release of the internal layer KGM stoped, pressure is the least, slice, thin piece not easy-formation, and it is frangible, and for tablet machine, pressure often changes in process of production, this situation makes the higher and very difficult control of requirement in the production process of konjaku flour dispersible tablet to craft precision, its quality control cost is the highest.
It addition, also convenience and take the problem of compliance, blood glucose to be reduced, reducing blood fat, the effect of fat-reducing, a dose of Rhizoma amorphophalli powder typically will be at more than 3g.For taking Rhizoma amorphophalli powder, if directly swallowing, because its surface area is big, contacting with liquid in oral cavity and i.e. quickly forming gel, volumetric expansion, block esophagus and trachea, therefore cannot directly swallow；The most first pour in water tumbler, take after the stirring that adds water, whipping process is easily formed gel and significantly affects and take effect；And cup need to be had just to take, cannot use in the case of without cup and stirring tool, be inconvenient for any personnel who go out.For taking capsule, every seed lac capsule dress 0.3g Rhizoma amorphophalli powder, the most also to take 10, the amount accepted far beyond common people, poor compliance.For taking tablet (including dispersible tablet), the every Rhizoma amorphophalli powder Han 0.3g, the most also to take 10, the amount also accepted beyond common people, compliance is the poorest.
Summary of the invention
It is an object of the invention to provide a kind of Rhizoma amorphophalli powder granule, this granule is swallowed by taking after mixing it with water, and taking convenience is simple, will not be stuck in the position such as oral cavity and esophagus, it scatter under one's belt after swallowing and imbibition, release viscosity, wraps up food, thus delays digestion process, play the good effect stabilizing Postprandial peak glucose, eater can be made simultaneously to produce satiety, reduce the absorption of food total amount, reduce blood glucose, reduce blood fat, the effect of fat-reducing.
It is a further object to provide the preparation method of above-mentioned Rhizoma amorphophalli powder granule.
A further object of the present invention is to provide the purposes of a kind of above-mentioned Rhizoma amorphophalli powder granule.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of Rhizoma amorphophalli powder granule, it includes Rhizoma amorphophalli powder and solid binder, does not contains liquid adhesive, it is characterised in that: the diameter of described granule or average diameter are 0.5-5mm, preferably 1-4mm；More preferably 1.5-3mm, more preferably 1.8-2.5mm.
Preferably, any one or a few in polyvinylpyrrolidone, carboxymethyl cellulose sodium, low-substituted hydroxypropyl cellulose, pregelatinized Starch, microcrystalline cellulose, the Polyethylene Glycol of described solid binder.
Typically, the moisture of Rhizoma amorphophalli powder granule is less than 5wt%, preferably shorter than 3wt%.
In general, the weight of described solid binder accounts for the 5-50wt% of Rhizoma amorphophalli powder granule gross weight, preferably 7-45wt%, more preferably 9-40wt%, more preferably 10-30wt%, more preferably 12-25wt%.
Preferably, possibly together with disintegrating agent in described granule；Disintegrating agent is selected from any one or a few in microcrystalline cellulose, carboxymethyl starch sodium, super sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, HPMC, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, pregelatinized Starch, chitin.The weight of disintegrating agent accounts for the 3-30wt% of Rhizoma amorphophalli powder granule gross weight, preferably 5-25wt%, more preferably 7-20wt%, more preferably 8-18wt%, more preferably 10-15wt%.
Preferably, possibly together with fluidizer in described granule；One or more in silicon dioxide, magnesium stearate, Pulvis Talci of fluidizer.The weight of fluidizer accounts for the 0.3-5wt% of Rhizoma amorphophalli powder granule gross weight, preferably 0.5-4.5wt%, more preferably 0.7-4.0wt%, more preferably 0.8-3wt%, more preferably 1.0-2wt%.
In general, described granule is spherical or class is spherical or draw ratio is the cylinder of 1:0.8-1.It addition, described granule can also have film coating.
The present invention also provides for preparing the preparation method of above-mentioned Rhizoma amorphophalli powder granule, and the method includes: takes the mixture comprising Rhizoma amorphophalli powder and solid binder and is directly compressed into granule as raw material, employing press.Preferably, described mixture also includes disintegrating agent.Typically, the content of disintegrating agent accounts for the 3-30wt% of total weight of the mixture, preferably 5-25wt%, more preferably 7-20wt%, more preferably 8-18wt%, more preferably 10-15wt%.It may further be preferable that described mixture also includes fluidizer.Typically, the content of fluidizer accounts for the 0.3-5wt% of total weight of the mixture, preferably 0.5-4.5wt%, more preferably 0.7-4.0wt%, more preferably 0.8-3wt%, more preferably 1.0-2wt%.
Preferably, press used above is a kind of press of the red seat with the drift of hemispheric notch and hemispheric notch.It is further preferred that the two recess is combined one spherical or class spherical hollow space of composition.Even more preferably, the size of the hemispheric notch of the hemispheric notch of drift and red seat meets Rhizoma amorphophalli powder particle diameter requirement.Or, press used above is a kind of press of the drift with cylindrical recess.Preferably, the draw ratio of this cylindrical recess is 1:0.8-1.It may further be preferable that the size of cylindrical recess meets Rhizoma amorphophalli powder particle diameter requirement.Particularity due to Rhizoma amorphophalli powder character, it is impossible to adding liquid binding agent, therefore be not suitable for using conventional wet granulation method to prepare.The present invention also provides for above-described Rhizoma amorphophalli powder granule or the purposes of Rhizoma amorphophalli powder granule prepared by said method, is: is used for described granule preparing and has fat-reducing, reduces blood glucose, the medicine reducing blood fat or health product.
Above-mentioned Rhizoma amorphophalli powder refers to the extraction of substance containing glucomannoglycan (KGM) extracted from Rhizoma amorphophalli.There are the materials such as Rhizoma amorphophalli powder, konjaku powder, Rhizoma amorphophalli fine powder, Rhizoma amorphophalli fine powder, Rhizoma amorphophalli extract, glucomannoglycan in the market, within these are all contained in the Rhizoma amorphophalli powder category of indication of the present invention.
Compared with prior art, the invention has the beneficial effects as follows: the Rhizoma amorphophalli powder granule instructions of taking of (1) present invention is simple, after pouring oral cavity into, takes after mixing it with water by edible liquid such as water, soup, beverages and swallows；Ideal at the dispersion dynamics of gastric, this granule can be not required to through disintegrate, it scatter the most under one's belt, can be fully contacted with food paste, during imbibition, discharge viscosity, wrap up food simultaneously, increase the viscosity of food paste, thus delay digestion process, play the good effect stabilizing Postprandial peak glucose.(2) after the granule during each enters stomach absorbs moisture content, its volume is expandable to about self 100 times, occupy gastric volume, so that eater produces satiety, reduce the absorption of food total amount, and KGM self empty calory, belong to pure plant fiber element, thus reduce blood glucose, reduce blood fat, the effect of fat-reducing.(3) granule is the least, and diameter is less than 5mm, takes after mixing it with water 3g-5g by edible liquid, will not be stuck in esophagus in oral cavity, and compliance is good.(4) being convenient to use and carry, granule is filled with amount every time with every bottle, directly pours oral cavity water into or beverage pours, i.e. can reach ideal effect when taking, and goes out to be also convenient for using.It is believed that Rhizoma amorphophalli powder granule of the present invention is KGM dietary fiber complementary goods one preferably food form or dosage form, also will assist in popularizing of KGM.
Especially, if using currently preferred Rhizoma amorphophalli powder preparation method of granules, using various Rhizoma amorphophalli powders as raw material, after adding suitable auxiliary materials and mixing, the press using drift size to meet Rhizoma amorphophalli powder particle diameter requirement is directly compressed into granule, traditional dry granulation method can also be greatly simplified, need not first material is compressed into tablet form thing cut again, the generation of amount of heat can be avoided, and material will not be caused significantly waste, improve production efficiency further, reduce production cost.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.
Embodiment 1-12
Press used in embodiment 1-6 and 10-12 is a kind of press of the red seat with the drift of hemispheric notch and hemispheric notch, and the two recess is combined one spherical hollow space of composition.The hemispheric notch of drift is corresponding with the diameter of Rhizoma amorphophalli powder granule with the size of the hemispheric notch of red seat.
The press that embodiment 7-9 is used is a kind of press of the drift with cylindrical recess.The draw ratio of this cylindrical recess is 1:0.9.The size of cylindrical recess is corresponding with the diameter of Rhizoma amorphophalli powder granule.
Component and the proportioning thereof of each embodiment see table, and its percentage ratio all represents percentage by weight.
Table 1
Various embodiments above all can be prepared by following various preparation methoies:
According to above-mentioned each enforcement component and proportioning thereof, respectively supplementary material is mixed, the press device using punch diameter (i.e. recess diameter) to be 0.5-5mm different size, be pressed into the granule of 0.5-5mm, to obtain final product.
For confirming the technique effect of the present invention, inventor has selected the granule made according to above-described embodiment 1 and 11 component and proportioning thereof directly for the Rhizoma amorphophalli powder granule of 2mm at random, carries out curative effect on obesity observation.Meanwhile, for ease of comparing, inventor has also selected following comparative example.
Comparative example 1
Rhizoma amorphophalli powder is the most treated, and direct packaging becomes the specification of every pouch 3g.
Comparative example 2
Rhizoma amorphophalli powder is packed into capsule, every seed lac capsule dress 0.3g.
Comparative example 3
By the patent No.: ZL200610020242.2 embodiment 11 prepares dispersible tablet, wherein containing 80% Rhizoma amorphophalli powder, 5% pregelatinized Starch, 15% microcrystalline cellulose, every tablet weight is 0.375g.
Curative effect and the advantage thereof of medicine of the present invention are proved by following clinical observation:
1, crowd is observed:
Select Body Mass Index BMI (body weight (kilogram)/height (rice2)) > crowd 250 example of 30 (are more than 30 fat), it is divided into 5 experimental grouies, each experimental group 50 people.
2, instructions of taking:
First group of Rhizoma amorphophalli powder taking comparative example 1, dose is each 3g, pours in water tumbler by Rhizoma amorphophalli powder when taking, add 300ml warm water, stir, together take down together with the gel formed, every day Chinese meal and dinner within first 5 minutes, respectively take once, appetite as usual is not made to control.
Taking the capsule that comparative example 2 prepares, each take 10, be equivalent to Rhizoma amorphophalli powder 3g for second group, capsule is put into when taking oral cavity by several times, gradation 300ml warm water is taken after mixing it with water, every day Chinese meal and dinner within first 5 minutes, respectively take once, appetite does as usual and does not makees to control.
Taking the dispersible tablet that comparative example 3 prepares for 3rd group, dose is each 10, is equivalent to Rhizoma amorphophalli powder 3g, and dispersible tablet is put into when taking oral cavity by several times, and gradation 300ml warm water is taken after mixing it with water, every day Chinese meal and dinner within first 5 minutes, respectively take once, appetite does as usual and does not makees to control.
Taking the granule prepared according to the embodiment of the present invention 1 component and proportioning thereof for 4th group, dose is each 3.6g, is equivalent to Rhizoma amorphophalli powder 3g, granule is poured into oral cavity when taking, take after mixing it with water with 300ml warm water, every day Chinese meal and dinner within first 5 minutes, respectively take once, appetite as usual is not made to control.
Taking the granule prepared according to the embodiment of the present invention 11 component and proportioning thereof for 5th group, dose is each 3.6g, is equivalent to Rhizoma amorphophalli powder 3g, granule is poured into oral cavity when taking, take after mixing it with water with 300ml warm water, every day Chinese meal and dinner within first 5 minutes, respectively take once, appetite as usual is not made to control.
3, efficacy evaluation:
Weigh before taking, be re-weighed after taking 30 days, using the weight of 2 minimizings of front and back as evaluation index, calculate the meansigma methods of each group of people group's loss of weight.
4, therapeutic effect is shown in Table 2:
Table 2
In table 2, (1) fourth, fifth group: compare with first group,##P ＜ 0.05；Compare with second group,***P ＜ 0.01；Compare with the 3rd group,◆◆P ＜ 0.05；(2) the 3rd groups: compare with second group,※※P ＜ 0.05.
Learnt by statistical data in table 2, take the granule that the present invention prepares the 4th group, 5th group of patient, take 30 days continuously, owing to particles with water is taken after mixing it with water after stomach, fully dispersed at gastric, quickly absorb moisture content, volume fully expands generation satiety, decrease the human body absorption to food, gel can be thoroughly mixed to form with food again simultaneously, decrease the human body absorption to food, so weight loss effect is best, with first, compare p ＜ 0.05 for three groups, there is significant difference, compared with second group, p ＜ 0.01, there is pole significant difference.Take the Rhizoma amorphophalli powder of comparative example 1, have satiety, decrease the absorption of food, although cannot be sufficiently mixed with food, but fat-reducing effect is well；Take the konjaku capsule of comparative example 2, owing to cannot disperse at gastric, without satiety after taking, the absorption of food will not be reduced, also cannot mix with food, it is impossible to reduce the absorption to food, so effect is worst.Taking the Rhizoma amorphophalli dispersible tablet of comparative example 3, disperse at stomach, have satiety, food intake dose reduces, and fat-reducing effect is better than first group, second group, compares p ＜ 0.05 with second group especially, has significant difference.
Experimental section
One, dispersibility compares
The dispersibility of medicine of the present invention is proved by tests below:
1, sample:
The granule that the Rhizoma amorphophalli powder of comparative example 1, the prepared capsule of comparative example 2, the prepared dispersible tablet of comparative example 3, the prepared granule of the embodiment of the present invention 1, the embodiment of the present invention 11 prepare.
2, test method:
Take each 3g of above sample (in terms of konjaku powder), put in 500ml beaker, add 50 DEG C of warm water 300ml, do not stir, stand, observe deployment conditions.The results are shown in Table 3.
Table 3
As shown in Table 3, the granule that the present invention prepares, dispersion is rapid and uniform, i.e. dispersibles complete during adding water, this point is particularly important, so user is during directly taking after mixing it with water with water, it is ensured that after granule enters stomach, i.e. dispersible, if and other dosage forms cannot be uniformly dispersed during adding water, even if the time longer also cannot redispersion, so granule is compared with other dosage forms, therapeutic effect has marked improvement.
Two, the parcel of food is compared
The parcel to food of medicine of the present invention is proved by tests below:
1, sample:
The granule that the Rhizoma amorphophalli powder of comparative example 1, the prepared capsule of comparative example 2, the prepared dispersible tablet of comparative example 3, the prepared granule of the embodiment of the present invention 1, the embodiment of the present invention 11 prepare.
2, test method:
(1) take each 3g of above sample (in terms of konjaku powder), put in 500ml beaker, add 50 DEG C of warm water 150ml.
(2) it is separately added into rice paste 50g and amylase, stirs 30 minutes (50 revs/min), take stirring thing 10g, add iodine liquid, the blue display degree of observation (without-, the most blue+, light blue ++, dark blue +++, royal purple ++++).The results are shown in Table 4.
Table 4
As shown in Table 4, the granule that the present invention prepares, dispersion is rapid and uniform, after adding rice paste, can it be wrapped up rapidly, even if by amylase hydrolysis, due to good package action, the glucose of hydrolysis also only spills on a small quantity and detected by iodine.Other dosage forms are all difficult good package action, and the glucose after hydrolysis can spill, so the granule that the present invention prepares is significant for diabetics, can reduce the post-prandial glycemia after diet.
Three, post-prandial glycemia comparitive study is reduced
Curative effect and the advantage thereof of medicine of the present invention reduction post-prandial glycemia are proved by following clinical observation:
1, crowd is observed:
Usually noon post-prandial glycemia is the patient of more than 13mmol/l.
2, instructions of taking:
First group of the 1st day normal lunch break, measures blood glucose after 2 hours；The Rhizoma amorphophalli powder taking comparative example 1 on 2nd day, dose is each 3g, pours in water tumbler by Rhizoma amorphophalli powder when taking, add 300ml warm water, stir, together take down together with the gel formed, after 5 minutes, normal lunch break (canteen kind is consistent with the 1st day with amount), measures blood glucose after 2 hours.
Second group of the 1st day normal lunch break, measures blood glucose after 2 hours；Within 2nd day, take the capsule that comparative example 2 prepares, each take 10, be equivalent to Rhizoma amorphophalli powder 3g, by several times capsule is put into oral cavity when taking, gradation 300ml warm water is taken after mixing it with water, and after 5 minutes, normal lunch break (canteen kind is consistent with the 1st day with amount), measures blood glucose after 2 hours.
3rd group of the 1st day normal lunch break, measures blood glucose after 2 hours；Within 2nd day, taking the dispersible tablet that comparative example 3 prepares, dose is each 10, is equivalent to Rhizoma amorphophalli powder 3g, by several times dispersible tablet is put into oral cavity when taking, gradation 300ml warm water is taken after mixing it with water, and after 5 minutes, normal lunch break (canteen kind is consistent with the 1st day with amount), measures blood glucose after 2 hours.
4th group of the 1st day normal lunch break, measures blood glucose after 2 hours；Within 2nd day, taking the granule that the embodiment of the present invention 1 prepares, dose is each 3.6g, is equivalent to Rhizoma amorphophalli powder 3g, granule is poured into oral cavity when taking, taking after mixing it with water with 300ml warm water, after 5 minutes, normal lunch break (canteen kind is consistent with the 1st day with amount), measures blood glucose after 2 hours.
5th group of the 1st day normal lunch break, measures blood glucose after 2 hours；Within 2nd day, taking the granule that the embodiment of the present invention 11 prepares, dose is each 3.6g, is equivalent to Rhizoma amorphophalli powder 3g, granule is poured into oral cavity when taking, taking after mixing it with water with 300ml warm water, after 5 minutes, normal lunch break (canteen kind is consistent with the 1st day with amount), measures blood glucose after 2 hours.
3, efficacy evaluation:
Measure often 2 blood glucose differences before and after group.
4, therapeutic effect is shown in Table 5:
Table 5
In table 5, (1) fourth, fifth group: compare with first group,##P ＜ 0.05；Compare with second group,***P ＜ 0.01；Compare with the 3rd group,◆◆P ＜ 0.05；(2) the 3rd groups: compare with second group,※※P ＜ 0.05.
Learnt by statistical data in table 5, take the 4th group of the granule that the present invention prepares, the 5th group of patient, the difference of post-prandial glycemia, p ＜ 0.05, has significant difference compared with first and third group, compared with second group, p ＜ 0.01, has pole significant difference, and effect is best；Take Rhizoma amorphophalli powder and the konjaku capsule of comparative example 2 of comparative example 1, owing to cannot effectively wrap up food, so effect is worst.Take the Rhizoma amorphophalli dispersible tablet of comparative example 3, better than second group of effect, but still it is inferior to medicine of the present invention.
Claims (9)
1. a Rhizoma amorphophalli powder granule, it includes Rhizoma amorphophalli powder and solid binder, does not contains liquid adhesive, it is characterised in that: the diameter of described granule or average diameter are 0.5-5mm, preferably 1-4mm；More preferably 1.5-3mm, more preferably 1.8-2.5mm.
Rhizoma amorphophalli powder granule the most according to claim 1, it is characterised in that: described solid binder is selected from any one or a few in polyvinylpyrrolidone, carboxymethyl cellulose sodium, low-substituted hydroxypropyl cellulose, pregelatinized Starch, microcrystalline cellulose, Polyethylene Glycol；And/or
The moisture of granule is less than 5wt%, preferably shorter than 3wt%.
Rhizoma amorphophalli powder granule the most according to claim 1 and 2, it is characterised in that: the weight of described solid binder accounts for the 5-50wt% of Rhizoma amorphophalli powder granule gross weight, preferably 7-45wt%, more preferably 9-40wt%, more preferably 10-30wt%, more preferably 12-25wt%.
4. according to the Rhizoma amorphophalli powder granule according to any one of claim 1-3, it is characterised in that: possibly together with disintegrating agent in described granule；Disintegrating agent is selected from any one or a few in microcrystalline cellulose, carboxymethyl starch sodium, super sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, HPMC, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, pregelatinized Starch, chitin；The weight of disintegrating agent accounts for the 3-30wt% of Rhizoma amorphophalli powder granule gross weight, preferably 5-25wt%, more preferably 7-20wt%, more preferably 8-18wt%, more preferably 10-15wt%.
5. according to the Rhizoma amorphophalli powder granule according to any one of claim 1-4, it is characterised in that: possibly together with fluidizer in described granule；One or more in silicon dioxide, magnesium stearate, Pulvis Talci of fluidizer；The weight of fluidizer accounts for the 0.3-5wt% of Rhizoma amorphophalli powder granule gross weight, preferably 0.5-4.5wt%, more preferably 0.7-4.0wt%, more preferably 0.8-3wt%, more preferably 1.0-2wt%.
6. according to the Rhizoma amorphophalli powder granule according to any one of claim 1-5, it is characterised in that: described granule is spherical or class is spherical or draw ratio is the cylinder of 1:0.8-1；And/or
Described granule has film coating.
7. the preparation method of the Rhizoma amorphophalli powder granule according to any one of claim 1-6, it is characterised in that: take the mixture comprising Rhizoma amorphophalli powder and solid binder and be directly compressed into granule as raw material, employing press；Preferably, described mixture also includes disintegrating agent, and the content of disintegrating agent accounts for the 3-30wt% of total weight of the mixture, preferably 5-25wt%, more preferably 7-20wt%, more preferably 8-18wt%, more preferably 10-15wt%；It may further be preferable that described mixture also includes fluidizer；The content of fluidizer accounts for the 0.3-5wt% of total weight of the mixture, preferably 0.5-4.5wt%, more preferably 0.7-4.0wt%, more preferably 0.8-3wt%, more preferably 1.0-2wt%.
Method the most according to claim 7, the press used in it is a kind of press of the red seat with the drift of hemispheric notch and hemispheric notch；Preferably, the two recess is combined one spherical hollow space of composition；It is further preferred that the size of the hemispheric notch of the hemispheric notch of drift and red seat meets Rhizoma amorphophalli powder particle diameter requirement；Or,
Press used in it is a kind of press of the drift with cylindrical recess, and the draw ratio of this cylindrical recess is 1:0.8-1；Preferably, the size of cylindrical recess meets Rhizoma amorphophalli powder particle diameter requirement.
9. Rhizoma amorphophalli powder granule according to any one of claim 1-8 or the purposes of Rhizoma amorphophalli powder granule prepared by the method described in claim 7-9, it is characterised in that: it is used for described granule preparing and there is fat-reducing, reduces blood glucose, the medicine reducing blood fat or health product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510106163.2A CN106031414A (en) | 2015-03-11 | 2015-03-11 | Konjak powdery particle, preparation method and applications thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510106163.2A CN106031414A (en) | 2015-03-11 | 2015-03-11 | Konjak powdery particle, preparation method and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106031414A true CN106031414A (en) | 2016-10-19 |
Family
ID=57151087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510106163.2A Pending CN106031414A (en) | 2015-03-11 | 2015-03-11 | Konjak powdery particle, preparation method and applications thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106031414A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112293735A (en) * | 2020-11-11 | 2021-02-02 | 内蒙古曼德拉生物科技有限公司 | Prinsepia utilis royle granules capable of benefiting smooth and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806671A (en) * | 2006-01-26 | 2006-07-26 | 罗克柱 | Konjaku flour dispersible tablet |
| CN1820775A (en) * | 2005-12-19 | 2006-08-23 | 余内逊 | Process for preparing micrometer yinlanzha, konjak, sugar, fat reaucing and weight reducing granule, capsule and tablet |
| CN101176553A (en) * | 2007-05-15 | 2008-05-14 | 刘五一 | Fresh fruit konjak functional food and preparation method thereof |
| CN102258494A (en) * | 2010-05-31 | 2011-11-30 | 北京理工大学 | Intra-gastric floating sustained-release tablets containing floating konjac glucomannan and preparation method thereof |
| CN103549422A (en) * | 2013-10-31 | 2014-02-05 | 贵州神奇药物研究院 | Konjac controlled-release colloidal particle |
-
2015
- 2015-03-11 CN CN201510106163.2A patent/CN106031414A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820775A (en) * | 2005-12-19 | 2006-08-23 | 余内逊 | Process for preparing micrometer yinlanzha, konjak, sugar, fat reaucing and weight reducing granule, capsule and tablet |
| CN1806671A (en) * | 2006-01-26 | 2006-07-26 | 罗克柱 | Konjaku flour dispersible tablet |
| CN101176553A (en) * | 2007-05-15 | 2008-05-14 | 刘五一 | Fresh fruit konjak functional food and preparation method thereof |
| CN102258494A (en) * | 2010-05-31 | 2011-11-30 | 北京理工大学 | Intra-gastric floating sustained-release tablets containing floating konjac glucomannan and preparation method thereof |
| CN103549422A (en) * | 2013-10-31 | 2014-02-05 | 贵州神奇药物研究院 | Konjac controlled-release colloidal particle |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112293735A (en) * | 2020-11-11 | 2021-02-02 | 内蒙古曼德拉生物科技有限公司 | Prinsepia utilis royle granules capable of benefiting smooth and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101926891B (en) | Composition for losing weight | |
| CN107518418A (en) | Application of the dietary fiber as metabolism regulators | |
| CN101416747A (en) | A kind of solid low-energy food that is rich in dietary fiber and preparation method thereof | |
| CN101999713B (en) | Spirulina tablets and preparation method thereof | |
| CN102919964A (en) | Mixed product comprising beta-glucan and preparation method of mixed product | |
| WO2018077275A1 (en) | Composition for protecting eyesight and preparation method therefor | |
| CN101912110B (en) | Composite with effects of losing weight and lowering blood sugar and blood lipid | |
| CN102077955B (en) | Soluble konjac dietary fiber tablets and preparation method thereof | |
| CN111228238B (en) | Pharmaceutical composition containing orlistat and oligosaccharide | |
| CN103083560A (en) | Tall gastrodia tuber and wild jujube seed composite capsules | |
| CN106031414A (en) | Konjak powdery particle, preparation method and applications thereof | |
| CN105380918A (en) | Acanthopanax trifoliatus polysaccharide tablet with blood sugar-reducing and health-care functions and preparation method thereof | |
| CN102018801B (en) | Novel digestion promoting tablets and preparation method thereof | |
| CN204568460U (en) | A kind of Chinese medicinal granule controlled release bubble drink device | |
| CN103734726A (en) | Soft-capsule type weight-losing food and preparation method thereof | |
| CN102895202A (en) | Cefetamet pivoxil hydrochloride dispersible tablet and preparation method thereof | |
| CN103564507B (en) | Weight losing granules | |
| CN101589806A (en) | A kind of solid low-energy food that is rich in dietary fiber and polyethylene glycol and preparation method thereof | |
| RU2792108C1 (en) | Thermostable filling for flour confectionery products based on components of plant origin (versions) | |
| CN108308500A (en) | A kind of konjaku, which relieves the effect of alcohol, reconstitutes drink and preparation method thereof | |
| CN108124991A (en) | A kind of corn stigma tea and preparation method thereof | |
| CN107242426A (en) | The sugared solid beverage of one kind control | |
| JP4647524B2 (en) | Dried konjac | |
| CN107158046A (en) | A kind of total ganoderma spore powder removes wall micropill | |
| CN107373275A (en) | Glucomannan effervescent tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161019 |
|
| RJ01 | Rejection of invention patent application after publication |