CN106018783A - 用于评估肾毒性的手段和方法 - Google Patents

用于评估肾毒性的手段和方法 Download PDF

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Publication number
CN106018783A
CN106018783A CN201610451174.9A CN201610451174A CN106018783A CN 106018783 A CN106018783 A CN 106018783A CN 201610451174 A CN201610451174 A CN 201610451174A CN 106018783 A CN106018783 A CN 106018783A
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China
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nephrotoxicity
biomarker
subject
acid
subjects
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CN201610451174.9A
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English (en)
Chinese (zh)
Inventor
H·坎普
T·B·沃克
B·V·拉文兹韦
W·梅勒特
E·法比安
V·施特劳斯
J·C·威尔莫
R·洛塞
M·M·赫罗尔德
A·普奥考汀
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BASF SE
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BASF SE
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/62—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/171538—Urea or blood urea nitrogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201610451174.9A 2011-09-14 2012-09-14 用于评估肾毒性的手段和方法 Pending CN106018783A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161534402P 2011-09-14 2011-09-14
EP11181219.4 2011-09-14
US61/534,402 2011-09-14
EP11181219 2011-09-14
EP11187016.8 2011-10-28
EP11187016 2011-10-28
CN201280044868.0A CN103814295B (zh) 2011-09-14 2012-09-14 用于评估肾毒性的手段和方法

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CN201280044868.0A Expired - Fee Related CN103814295B (zh) 2011-09-14 2012-09-14 用于评估肾毒性的手段和方法

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US (1) US20150011423A1 (enExample)
EP (1) EP2756304A4 (enExample)
JP (1) JP2014530350A (enExample)
KR (1) KR20140074293A (enExample)
CN (2) CN106018783A (enExample)
CA (1) CA2845117A1 (enExample)
IL (1) IL230937A0 (enExample)
WO (1) WO2013038369A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN107422062A (zh) * 2017-05-26 2017-12-01 广东产品质量监督检验研究院 一种同时测定保健食品中苯溴马隆、别嘌醇和丙磺舒含量的方法
CN112639477A (zh) * 2018-09-29 2021-04-09 诺码锐思股份公司 用于精确预测肾小球滤过率和用于指示肾小球滤过率受损的病理生理因素的生物标志物

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CA3184836A1 (en) * 2013-05-14 2014-11-20 Metabolon, Inc. Biomarkers related to kidney function and methods using the same
CN104614291B (zh) * 2015-01-13 2018-01-16 江苏普瑞姆纳米科技有限公司 评估大气细颗粒物暴露对生物体毒性作用的标志物和方法
CN107589200B (zh) * 2017-09-15 2020-06-16 山东省科学院生物研究所 一种利用诊断标志物评价微量外源化学物早期毒性的方法及其应用
CN108426956B (zh) * 2018-04-13 2020-10-09 郑州泰丰制药有限公司 一种高效液相色谱法测定卡托普利片中杂质f的方法
CN115469026B (zh) * 2022-07-14 2023-10-20 中日友好医院(中日友好临床医学研究所) 用于检测环孢素a肾毒性相关标志物的检测试剂、试剂盒及其用途

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CN1355885A (zh) * 1999-05-14 2002-06-26 昂科俄勒特控股有限公司 预测和/或诊断发展成胃癌危险性的方法

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EP1941274B1 (en) * 2005-09-09 2015-08-19 Medizinische Universität Innsbruck Method for predicting the progression of chronic kidney disease by measuring apolipoprotein a-iv
US8084262B2 (en) * 2006-04-05 2011-12-27 Hoffmann-La Roche Inc. Biomarker for farnesyl pathway
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US8658427B2 (en) * 2008-05-28 2014-02-25 Basf Se Means and methods for assessing increased peroxisomal proliferation
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107422062A (zh) * 2017-05-26 2017-12-01 广东产品质量监督检验研究院 一种同时测定保健食品中苯溴马隆、别嘌醇和丙磺舒含量的方法
CN107422062B (zh) * 2017-05-26 2019-06-25 广东产品质量监督检验研究院 一种同时测定保健食品中苯溴马隆、别嘌醇和丙磺舒含量的方法
CN112639477A (zh) * 2018-09-29 2021-04-09 诺码锐思股份公司 用于精确预测肾小球滤过率和用于指示肾小球滤过率受损的病理生理因素的生物标志物
CN112639477B (zh) * 2018-09-29 2024-04-09 诺码锐思股份公司 用于精确预测肾小球滤过率和用于指示肾小球滤过率受损的病理生理因素的生物标志物

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CN103814295B (zh) 2016-08-24
IL230937A0 (en) 2014-03-31
KR20140074293A (ko) 2014-06-17
CN103814295A (zh) 2014-05-21
EP2756304A4 (en) 2015-06-10
JP2014530350A (ja) 2014-11-17
EP2756304A1 (en) 2014-07-23
US20150011423A1 (en) 2015-01-08
CA2845117A1 (en) 2013-03-21
WO2013038369A1 (en) 2013-03-21

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Application publication date: 20161012