CN105999246A - Hirudin and dried-leech medicinal liquor and preparation method and application thereof - Google Patents
Hirudin and dried-leech medicinal liquor and preparation method and application thereof Download PDFInfo
- Publication number
- CN105999246A CN105999246A CN201610422962.5A CN201610422962A CN105999246A CN 105999246 A CN105999246 A CN 105999246A CN 201610422962 A CN201610422962 A CN 201610422962A CN 105999246 A CN105999246 A CN 105999246A
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- CN
- China
- Prior art keywords
- hirudin
- carbon dioxide
- solid carbon
- chinese liquor
- medicated wine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
Provided are a medicinal hirudin and dried-leech liquor. 400-600 g of fresh hirudin extracted from leeches and dried leeches from are soaked in 30-40 degrees of 500 ML baijiu, sealed storage is performed to obtain a mother liquor, and then the mother liquor is diluted with the baijiu into the medicinal hirudin and dried-leech liquor. The baijiu can be baijiu of various degrees, the baijiu of more than 40 degrees is more ideal, and the baijiu of more than 50 degrees is recommended. The medicinal hirudin and dried-leech liquor can be used for treatment of thrombosis, hyperlipidemia and hypertension.
Description
Technical field
The present invention relates to a kind of medicated wine, the medicine prepared more particularly to a kind of hirudin and solid carbon dioxide trematodiasis
Wine.
The invention still further relates to above-mentioned hirudin and the preparation method of solid carbon dioxide trematodiasis medicated wine.
The invention still further relates to above-mentioned hirudin and solid carbon dioxide trematodiasis medicated wine at treatment thrombotic disease, high fat of blood, height
Application in terms of blood pressure diseases.
Background technology
Hirudin is the activity with the strongest blood coagulation resisting function extracted from Hirudo (being commonly called as Hirudo)
Composition, has been used for extensively carrying out the research treating various thrombus diseases, such as:
Anticoagulation and antithrombotic；
Reduce surface activity of blood platelet, suppress platelet aggregation, reduce platelet adhesion reaction；
Reduce blood viscosity；
Reduce blood fat etc..
From the point of view of comprehensive existing report, owing to the hirudin extracted is generally liquid, it is therefore desirable to
It is processed making dry powdery or lamellar by liquid hirudin, during to preserving longer
Between, then make injection and oral agents etc. further according to demand.
During hirudin is processed, inevitably reduce biological activity in hirudin,
Thus reduce the curative effect of hirudin.
Hirudin in Hirudo cannot all be extracted totally, Hirudo by the technique extracting hirudin at present
The internal part hirudin that also leaves, simultaneously for ease of long-time preservation, after the most all extracting hirudin
Hirudo make dry raw trematodiasis (such as dry, oven drying at low temperature, lyophilizing etc.).
Although solid carbon dioxide trematodiasis also remains with part hirudin, but its negligible amounts, if being intended to use known
Its second time is extracted by technology, then DeGrain, if given it up, causes waste.
Therefore this part hirudin should be utilized fully.
Summary of the invention
It is an object of the invention to provide a kind of hirudin and solid carbon dioxide trematodiasis medicated wine.
It is yet another object of the invention to provide a kind of method preparing above-mentioned hirudin and solid carbon dioxide trematodiasis medicated wine.
For achieving the above object, the present invention provides hirudin and solid carbon dioxide trematodiasis medicated wine are by following method
Obtain:
1) fresh hirudin 400g-600g Hirudo extracted and the solid carbon dioxide trematodiasis of 1000g-2000g steep in
Sealed type storage in the 500ML Chinese liquor of 30-40 degree, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to hirudin and the solid carbon dioxide trematodiasis medicated wine of arbitrary proportion.
In described hirudin and solid carbon dioxide trematodiasis medicated wine, step 1 is the fresh water extracted by 500g Hirudo
The solid carbon dioxide trematodiasis of trematodiasis element and 1500g steeps sealed type storage in the 500ML Chinese liquor of 35 degree.
In described hirudin and solid carbon dioxide trematodiasis medicated wine, the Chinese liquor of step 2 is the Chinese liquor of more than 50 degree.
The method preparing above-mentioned hirudin and solid carbon dioxide trematodiasis medicated wine that the present invention provides is；
1) fresh hirudin 400g-600g Hirudo extracted and the solid carbon dioxide trematodiasis of 1000g-2000g steep in
Sealed type storage in the 500ML Chinese liquor of 30-40 degree, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to hirudin and the solid carbon dioxide trematodiasis medicated wine of arbitrary proportion.
In described preparation method, step 1 is the fresh hirudin and 1500g extracted by 500g Hirudo
Solid carbon dioxide trematodiasis steep sealed type storage in the 500ML Chinese liquor of 35 degree.
In described preparation method, the Chinese liquor of step 2 is the Chinese liquor of more than 50 degree.
The hirudin of the present invention and solid carbon dioxide trematodiasis medicated wine may be used for treating thrombotic disease, high fat of blood, high blood
Pressure disease.
The hirudin of the present invention and solid carbon dioxide trematodiasis medicated wine can keep the biological of hirudin to live to greatest extent
Property, it is used for regulating blood fat, elimination fatty liver, directly dissolving thrombosis, elimination atherosclerosis, anti-
Only apoplexy and again apoplexy, the corroded rock mass of human activin self, it is to avoid again produce thrombolytic etc., with
And maximally utilise hirudin.
Detailed description of the invention
Fresh hirudin and solid carbon dioxide trematodiasis are dissolved in Chinese liquor by the present invention, make hirudin and solid carbon dioxide trematodiasis medicine
Wine, had both overcome the strange taste of hirudin, and can retain again the biological activity of hirudin.
Hirudin itself has a kind of fishy smell, and Chinese liquor then taste is pure and sweet, and end opening makes us aftertaste, simultaneously wine
Also it is a kind of good organic solvent, there is preferable penetrance.Wine can make major part water-soluble substances,
And some water can not dissolve the Cucumber maybe needing could to dissolve with nonpolar solvent and be dissolved in wine (second
Alcohol) in.This effect can make wine be easier to enter in Chinese crude drug histiocyte, by portion big in Chinese crude drug
Various different organic substances are divided to be dissolved out, to play the original therapeutical effect of crude drug.
The medicated wine that wine is made after also having antisepsis, wine and Chinese Medicine and Clavicular, can play to greatest extent
The effect of Chinese medicine, has again preferable stability.Scientific investigations showed that, when ethanol content is more than 18%
Time, the hydrolytic spoilage of medicine can be delayed, strengthen the stability of medicament.The highest containing amount of alcohol, medicament
Anti-corrosive properties the highest.So, medicated wine is easier long-term storage, is suitable for old and chronic disease
The long-term taking of patient.
Chinese liquor itself be food be also a herb, the most just have " length that wine is hundred medicines "
Saying.The research of modern medicine shows: the ethanol (ethanol) in wine can be by the dehydrogenase of alcohol in human body
It is oxidized to acetaldehyde, is then oxidized to acetic acid.This oxidizing process can promote internal blood circulation, makes
Blood flow is accelerated, pulse accelerates, accelerated breathing.Therefore, responsible drinking can increase cell viability, solves
Except fatigue, increase body temperature；Gastrointestinal secretion can also be promoted, help digest.
The present invention is integrated the most molten to hirudin and Chinese liquor, forms a kind of existing therapeutical effect, again
There is the beverage of health care.The hirudin medicated wine made both can treat disease, may be used for again after being ill
Auxiliary treatment, moreover it is possible to play diseases prevention and be healthy and strong, the anti-ageing effect prolonged life.
Hereinafter the invention will be further described in citing:
Fresh hirudin is extracted, then with the solid carbon dioxide utilizing known method to prepare by known method
Trematodiasis (solid carbon dioxide trematodiasis can be shredded) joins in low alcohol white spirit together and shakes up, when bottle sealing stores one section
Chien shih hirudin is thoroughly dissolved in Chinese liquor, makes mother solution, then when needs are taken again with Chinese liquor by reality
The needs that border is drunk are diluted, and i.e. obtain fresh hirudin and the medicated wine of dry hirudin.
It is the low alcohol white spirit with 30-40 degree that the present invention prepares the low alcohol white spirit of mother solution, the fresh water of addition
The amount of trematodiasis element is to occur without saturated being as the criterion, and the present invention preferably scheme is to be extracted by 400g-600g Hirudo
Fresh hirudin and the solid carbon dioxide trematodiasis of 1000g-2000g steep in 35 degree of 500ML low alcohol white spirits in the moon
Liang Chu stores more than three months.Preferably every 500ML low alcohol white spirit adds the extraction of 500g Hirudo
Hirudin and the solid carbon dioxide trematodiasis of 1500g, be diluted to arbitrary proportion with Chinese liquor again after storing four months and take.
The number of degrees of the present invention Chinese liquor for diluting mother solution do not have considered critical, can be the various number of degrees
Grain neutral spirit (such as jowar wine, corn wine etc.), specifically can be according to the tolerance ethanol ability of drinking person
Fixed, the drinking person that tolerance ethanol ability is relatively low can be used low alcohol white spirit, higher to tolerance ethanol ability
Drinking person can use high spirit.For the effect of medicated wine, preferably more than 40 degree
Chinese liquor, it is recommended that use the Chinese liquor of more than 50 degree.
The hirudin of following example and dry hirudin medicated wine are the fresh waters first extracted by 500g Hirudo
The solid carbon dioxide trematodiasis (solid carbon dioxide trematodiasis can be shredded) of trematodiasis element and 1000g-2000g is steeped in 35 degree of 500ML low
After in Chinese liquor, at cool place, storage makes mother solution in four months, it is 56 degree white according still further to 400ML concentration
As a example by wine adds the hirudin made of 100ML mother solution and dry hirudin medicated wine.
Embodiment 1
Obtaining sufferers themselves to agree to, 4 suffer from slight thrombus sequela and limbs inconvenience (mainly one
Lower limb or the arm of side have feeling of numbness) the patient every day of each 50ML sooner or later.4 people's limbs sensations after 7 days
There is raising in various degree.
Embodiment 2
Obtaining sufferers themselves to agree to, the patient that 5 blood fat are higher respectively takes the 50ML present invention every day sooner or later
Medicated wine, after 5 days detect blood fat all have decline in various degree.
Embodiment 3
Obtain sufferers themselves to agree to, 4 are suffered from hypertension and the most dizzy patient is the most each for every day
Take the medicated wine of the 50ML present invention.Take dizzy sense in 4 days substantially to alleviate, measure blood pressure and tend to normal.
Claims (9)
1. hirudin and a solid carbon dioxide trematodiasis medicated wine, is obtained by following method:
1) fresh hirudin 400g-600g Hirudo extracted and the solid carbon dioxide trematodiasis of 1000g-2000g steep in
Sealed type storage in the 500ML Chinese liquor of 30-40 degree, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to hirudin and solid carbon dioxide trematodiasis medicated wine.
Hirudin the most according to claim 1 and solid carbon dioxide trematodiasis medicated wine, wherein, step 1 be by
Fresh hirudin and the solid carbon dioxide trematodiasis of 1500g that 500g Hirudo is extracted are steeped in the 500ML Chinese liquor of 35 degree
Sealed type storage.
Hirudin the most according to claim 1 and solid carbon dioxide trematodiasis medicated wine, wherein, step 2 white
Wine is the Chinese liquor of more than 50 degree.
4. hirudin described in claim 1 and the preparation method of solid carbon dioxide trematodiasis medicated wine；
1) fresh hirudin 400g-600g Hirudo extracted and the solid carbon dioxide trematodiasis of 1000g-2000g steep in
Sealed type storage in the 500ML Chinese liquor of 30-40 degree, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to hirudin medicated wine.
Preparation method the most according to claim 4, wherein, step 1 is to be carried by 500g Hirudo
The fresh hirudin taken and the solid carbon dioxide trematodiasis of 1500g steep sealed type storage in the 500ML Chinese liquor of 35 degree.
Preparation method the most according to claim 4, wherein, the Chinese liquor of step 2 be 50 degree with
On Chinese liquor.
7. hirudin described in claim 1 and solid carbon dioxide trematodiasis medicated wine are in preparation treatment thrombotic disease medicine
Application.
8. hirudin described in claim 1 and solid carbon dioxide trematodiasis medicated wine are in preparation treatment high fat of blood medicine
Application.
9. hirudin described in claim 1 and solid carbon dioxide trematodiasis medicated wine are in preparing Hypertension medicine
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610422962.5A CN105999246A (en) | 2016-06-14 | 2016-06-14 | Hirudin and dried-leech medicinal liquor and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610422962.5A CN105999246A (en) | 2016-06-14 | 2016-06-14 | Hirudin and dried-leech medicinal liquor and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999246A true CN105999246A (en) | 2016-10-12 |
Family
ID=57087616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610422962.5A Pending CN105999246A (en) | 2016-06-14 | 2016-06-14 | Hirudin and dried-leech medicinal liquor and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999246A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107674805A (en) * | 2017-11-22 | 2018-02-09 | 广西远程水蛭养殖有限公司 | Honeysuckle wine and preparation method |
| CN107714952A (en) * | 2017-09-27 | 2018-02-23 | 黄新年 | A kind of leech health liquor and preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3432596A (en) * | 1967-10-13 | 1969-03-11 | Dresden Arzneimittel | Method for producing highly pure hirudine |
| CN101019964A (en) * | 2007-02-05 | 2007-08-22 | 周维海 | Health wine with leech and its production process |
| CN102085357A (en) * | 2011-01-14 | 2011-06-08 | 重庆时珍阁普生药业有限公司 | Purpose of medicine adopting hirudin and hementerin as raw materials |
| CN102964446A (en) * | 2012-11-28 | 2013-03-13 | 周维官 | Method for repeatedly extracting natural hirudin from live vampire leech |
-
2016
- 2016-06-14 CN CN201610422962.5A patent/CN105999246A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3432596A (en) * | 1967-10-13 | 1969-03-11 | Dresden Arzneimittel | Method for producing highly pure hirudine |
| CN101019964A (en) * | 2007-02-05 | 2007-08-22 | 周维海 | Health wine with leech and its production process |
| CN102085357A (en) * | 2011-01-14 | 2011-06-08 | 重庆时珍阁普生药业有限公司 | Purpose of medicine adopting hirudin and hementerin as raw materials |
| CN102964446A (en) * | 2012-11-28 | 2013-03-13 | 周维官 | Method for repeatedly extracting natural hirudin from live vampire leech |
Non-Patent Citations (3)
| Title |
|---|
| 吴渊清: "怎样浸制药酒", 《老友》 * |
| 周进科；刘翠萍: "凝血酶抑制剂——水蛭素", 《中国新药杂志》 * |
| 欧兴长等: "水蛭素的研究概况", 《中国药学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714952A (en) * | 2017-09-27 | 2018-02-23 | 黄新年 | A kind of leech health liquor and preparation method and application |
| CN107674805A (en) * | 2017-11-22 | 2018-02-09 | 广西远程水蛭养殖有限公司 | Honeysuckle wine and preparation method |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161012 |
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| RJ01 | Rejection of invention patent application after publication |