KR20130010922A - Crude-drug composites for hypoglycemic effect and manufacturing method thereof - Google Patents

Abstract

PURPOSE: A crude drug composition which reduces blood glucose and a method for manufacturing the same are provided to prevent and treat diabetes(type 1 and type 2) and to reduce low density lipoprotein(LDL). CONSTITUTION: A crude drug composition contains 100 parts by weight of black garlic, 62.5-850 parts by weight of balsam pear, 250-2500 parts by weight of edible snail, 0.375-4.5 parts by weight of cocoon protein hydrolysate, 7.5 parts by weight of a ginkgo leaf extract, and 0.0075-0.4 parts by weight of L-lysine. A method for manufacturing the composition comprises: a step of adding black garlic, balsam pear, and yam to an ethanol solution and maturing the mixture at 0-5 deg. C.(S10); a step of adding the ginkgo leaf extract and edible snail to the supernatant of the mixture and maturing at 0-5 deg.C.(S20); a step of adding L-lysine and maturing at 0-5 deg.C.(S30); a step of adding cocoon protein hydrolysate and maturing at 0-5 deg.C.(S40); and a step of volatilizing and removing the ethanol ingredients(S50). [Reference numerals] (S10) First maturing step of adding black garlic, balsam pear, and yam to an ethanol solution and maturing; (S20) Second maturing step of adding ginkgo leaf extract and edible snail to the supernatant of the mixture, manufactured from the first maturing step, and maturing; (S30) Third maturing step of adding L-lysine to the supernatant of the mixture, manufactured from the second maturing step, and maturing; (S40) Fourth maturing step of adding cocoon protein hydrolysate to the supernatant of the mixture, manufactured from the third maturing step, and maturing; (S50) Step of obtaining a crude drug composition by volatilizing and removing ethanol ingredients manufactured from the fourth maturing step

Description

Crude-drug Composites for Hypoglycemic Effect and Manufacturing Method

The present invention relates to a herbal composition and a method for producing the same, and more particularly, black garlic, bitter gourd, yam, edible snail, cocoon protein hydrolyzate, ginkgo biloba extract, and L-Lysine, which are natural animal and plant herbals. It acts on the pathogenesis of hyperglycemia, which is the main cause of diabetic complications, including macrovascular complications (arteriosclerosis, stroke, myocardial infarction and lower limb artery obstruction) and small vessel complications (diabetic retinopathy, diabetic nephropathy, The present invention relates to a herbal composition having a hypoglycemic effect effective for the prevention of diabetic neuropathy) and a preparation method thereof.

The number of diabetics in the world has already surpassed 200 million, and is expected to double by 2025. Diabetes Mellitus is a symptom of hyperglycemia with abnormally high blood glucose levels. This symptom is mainly caused by problems with insulin secretion in the pancreas, resulting in long-term abnormalities in the metabolism of nutrients such as carbohydrates, fats and proteins. Representative symptoms include Daum (다, 多 뇨), Dasik (多 食).

Because of hyperglycemia in the blood, glucose and large amounts of water are excreted in the urine due to osmotic pressure, and the discharge of urine becomes frequent, resulting in dehydration, thirst and fasting.

In type 1 diabetes, the beta-cell of the pancreas is damaged and there is little or no insulin secretion.It is related to the HLA antigen, which is a gene, and is caused by infections such as viruses and bacteria as antigenic factors. It alters the immunogen of the surface antigen of insulin secreting cells and has an autoimmune mechanism.

It occurs mainly in people under 40, and the disease progresses rapidly. This can lead to serious symptoms such as ketoacidosis. In this case, the only way is to supply insulin from the outside.

The causes of type 1 diabetes are genetic, as well as stress, viral and pancreatic damage. In the United States, about 5 to 10% of diabetics correspond to type 1 diabetes, but type 1 diabetes is rare in Korea. Recently, attempts have been made to delay the onset of prevention before type 1 diabetes occurs.

Type 2 diabetes is insulin independent diabetes and usually develops after 40s. It is caused by pancreatic impairment due to aging and a decrease in insulin efficiency, called adult disease diabetes. The cause of the disease is not known yet, but it is caused by genetic and environmental factors.

Genetic factors include family history, environmentally high calorie ingestion of the pancreas, excessive stress, drug abuse, hormonal imbalance, lack of exercise and obesity.

Type 2 diabetes is mainly caused by insulin resistance, and long-term high levels of insulin in the blood accelerate carbohydrate-to-fat conversion, leading to hyperlipidemia and hypertension. Therefore, special care should be taken for obesity. For example, waist circumference has been reported to be useful for predicting adult disease diabetes.

In Korea, type 2 diabetes can be said. In this case, the treatment does not use insulin, and ketoacidosis does not occur. If these symptoms are mild, food control and exercise alone can be controlled. In addition to weight loss to increase physical activity, stimulating insulin receptors to relieve insulin resistance has great significance in the treatment of chronic diseases.

It is no exaggeration to say that diabetes is a fight against complications. Since complications develop in proportion to the number of years of illness, they often progress until they are discovered. Another case occurs by chance five to six years after diabetes.

Diabetic complication refers to blood vessel damage. It causes problems with the heart, brain and feet, leading to large-vascular complications (cardiovascular diseases such as angina pectoris and hypertension) and small-vascular complications (retinal, neurodegenerative and renal inflammation). It is important to lower the high blood sugar serious injury, which is the main cause, to lower the normal blood sugar level.

In the treatment of diabetes, hypoglycemic agents include sulfonylureas, biguanides and acarbose, but sulfonylureas frequently cause complications related to hypoglycemia, vomiting, jaundice, It may cause hot flashes and sweating, and it may cause heart and hematopoietic dysfunction in long-term use.A biguanide-based drug causes side effects such as anorexia, nausea and diarrhea and gastric acidosis. Inhibitors of α-Glucosidase have been reported to cause vomiting, diarrhea and bloating.

In the case of NPH (Neutral Protamine Hagedorn) insulin in the form of an injection, the blood sugar lowering effect is excellent, but there is an inconvenience in using the method, and the use of glucose in the blood may cause a sharp drop in the concentration.

In addition to such drug therapy, there are folk remedies, and simple and effective diabetic regulators using natural resources herbal medicines have been reported to date, and many studies have recently been conducted on treatments using immunosuppressants.

Therefore, an object of the present invention is to promote insulin secretion of pancreatic cells to treat type 1 diabetes, to increase insulin resistance, and to treat type 2 diabetes. To provide a herbal composition having an antihyperglycemic effect, including an edible snail, cocoon protein hydrolyzate, ginkgo biloba extract, and L-lysine, and a method for preparing the same.

The present invention for achieving the above object provides a herbal composition comprising black garlic, bitter gourd, yam, edible snail, cocoon protein hydrolyzate, ginkgo leaf extract, and L-lysine.

Here, based on 100 parts by weight of the black garlic, the gourd 62.5 to 850 parts by weight, the yam is 75 to 1200 parts by weight, the edible snail is 250 to 2500 parts by weight, the cocoon protein hydrolyzate is 0.375 to 4.5 parts by weight , The ginkgo leaf extract may be 7.5 to 200 parts by weight and the el-lysine may be 0.0075 to 0.4 parts by weight.

And the herbal composition further includes vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, arginine, glutathione and apple juice, woody liquor, propolis and fragrance It may further include at least one additive selected from the group consisting of.

Meanwhile, the present invention adds black garlic, bitter gourd and yam to an ethanol aqueous solution, and then, ginkgo biloba extract and edible snail in the supernatant of the mixture prepared in the first aging step and the first aging step of aging at 0-5 ° C. After the addition, the second aging step of maturing at the condition of 0 to 5 ℃, El-lysine is added to the supernatant of the mixture prepared in the second aging step, and then aged at 0 to 5 ℃ After the third aging step, the cocoon protein hydrolyzate is added to the supernatant of the mixture prepared in the third aging step, the fourth aging step of aging under conditions of 0 to 5 ℃, and the fourth aging It provides a method for producing a liquid herbal composition comprising an ethanol removal step of volatilizing and removing the ethanol component of the mixture prepared in the step to obtain a liquid herbal composition.

Wherein in the third aging step, the supernatant of the mixture prepared in the second aging step of vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, Arginine, glutathione and apple juice may be further added.

And further adding at least one additive selected from the group consisting of wood vinegar, propolis, and incense in the fourth ripening step, and further comprising a fifth ripening step of ripening under conditions of 0 to 5 ° C. .

After the ethanol removal step, the liquid herbal composition is sterilized by boiling water for 0.5 to 1 hour under conditions of 80 to 90 ° C., or heat treated for 0.5 to 1 hour under conditions of 100 to 110 ° C. using an autoclave. It may further comprise the step.

On the other hand, the present invention provides a herbal composition in the form of a solid powder further comprising the step of reducing, heating and drying the obtained liquid herbal composition.

The herbal composition according to the present invention has a prophylactic and therapeutic effect of diabetes mellitus (types 1 and 2), increases blood vessel damage and pancreatic insulin secretion ability for diabetic complications, and is superior to immune strengthening. As an herbal composition, various secondary effects such as improvement of intestinal environment, reduction of low density lipoprotein (LDL), promotion of digestive absorption, prevention and improvement of constipation, and immunity enhancement can be expected by unidentified fermentation products.

In addition, the herbal composition according to the present invention contributes to protein metabolism and synthesis, and may exhibit an effect of minimizing side effects due to diabetes by inhibiting pain expression.

1 is a flow chart showing a method for preparing a herbal composition having a hypoglycemic effect according to the present invention.

In the following description, only parts necessary for understanding the operation according to the embodiment of the present invention will be described, it should be noted that the description of other parts will be omitted so as not to obscure the subject matter of the present invention.

Also, the terms and words used in the present specification and claims should not be construed to be limited to ordinary or dictionary meanings, and the inventor is not limited to the concept of terms in order to describe his invention in the best way. It should be construed in accordance with the meaning and concept consistent with the technical idea of the present invention based on the principle that it can be properly defined. Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely one preferred embodiment of the present invention, and not all of the technical ideas of the present invention are described. Therefore, It is to be understood that equivalents and modifications are possible.

The present invention is a composition for lowering blood sugar using natural animal and plant herbal medicines, and more specifically, black garlic, bitter gourd, yam, edible snail, cocoon protein hydrolyzate, ginkgo leaf extract, and L-lysine (L-lysine). A herbal composition and a method for producing the same.

The herbal composition is a mixed extract containing a single extract of a drug which is a raw material thereof, and may be a liquid extract. The liquid extract may be obtained as a solid powder by depressurizing, heating and drying the liquid extract, and lyophilized. It may be.

As black garlic used in the present invention, black garlic obtained by ripening and fermenting fresh garlic at a temperature of 60 to 70 ° C. and a humidity of 85 to 95% for at least 40 days is used.

Garlic is a perennial plant of the genus Allium belonging to the family Liliaceae. It is estimated to originate from Central Asia and the Mediterranean, and it is known to Korea through China. Traditional medicines such as hypertension, heart disease, diabetes and cancer have alliin, an organic sulfur compound useful for the human body.

Garlic has been reported to exhibit physiological activities such as lowering cholesterol, inhibiting platelet aggregation, lowering blood pressure, and antioxidants. Allyin is garlic's unique volatile fragrance, which is broken down into Allicin by Alliinase. Decompose to Raw garlic removes reactive oxygen species as an antioxidant and enhances the effects of lipid peroxidation, low density lipoprotein (LDL) oxidation and antioxidants.

On the other hand, allicin, known as the main active ingredient of raw garlic, is extremely unstable to heat and can damage normal cells and their tissues when ingested. Therefore, raw garlic is aged and fermented by garlic processing at a temperature of 60 to 70 ° C. and a humidity of 85 to 95% for at least 40 days by spontaneous short-term fermantation, and the alpha-amino (α-Amino) group in the protein The non-enzymatic browning reaction caused by sulfur reaction occurs and the whole garlic is blackened by enzymes of raw garlic itself during aging of garlic, and is commercially available in the market.

In black garlic, the enzyme activity due to heat is reduced, and the content of allicin is reduced, and the antioxidant activity, polyphenols, flavonoids and sugars are increased.

In addition, the odorous components are removed during the aging process and contain s-allycysteine and fat-soluble substances which are stable and have no unpleasant odors.

When the above-mentioned extract of black garlic is ingested for 7 days, it has been reported that the sensitivity of low-density lipoproteins to the oxidation is reduced, and it suppresses the elevation of hyperglycemia and cortosterone. Anti-diabetic action of black garlic helps insulin resistance and normalizes beta cells, and activates beta-cells after prolonged ingestion, thus preventing the occurrence of type 1 diabetes.

Litchi used in the present invention may include all of the fruit, leaves and seeds of the bitter gourd, and may also include the bitter gourd ethanol and the bitter methanol extract.

Yeoju is a gourd and plant, and it is called Yeoju or woman in Korea and bears fruit in June ~ August, and is used as a vegetable or as an ornamental. Growing under the sunshine of summer, the green is dark and humps are bumpy. The more the bitterness is, the more active ingredients are contained. It is used in a wide range of fruits, leaves, seeds, roots, etc. and is harvested less ripe.

Yeoju's typical efficacy is anti-cancer, anti-necrosis, anti-hyperglycemic action, hypoglycemia can prevent diabetes, and has good efficacy for parasites, night blindness, gout, peptic ulcer, pneumonia, malaria and skin disease. Yeasts include glucoside, saponin, alkaloid, protein and sterol compounds, vitamin C, beta-carotene, potassium, iron and Minerals, etc. are included.

Plant insulin and charantin, which have been found to have antidiabetic effects, are two types of peptides that function similarly to insulin in the body, and are contained in the fruit and seeds of yeast. Phytoinsulin helps to burn sugar in the liver, prevents glucose from resynthesizing in the body, and caranthine is a fat-soluble component that raises the function of the pancreas to secrete insulin, thereby lowering blood sugar. Yeoju also contains many antioxidants such as beta-carotene, which can prevent diabetic complications such as retinopathy, neurodegeneration and cardiovascular diseases.

In particular, the immature fruit is a major source of vitamin C, vitamin A and iron, and vitamin C contained in the yeast is hardly destroyed even when heated.

Yeoju has such various physiological and pharmacological effects, and further increases its availability as well as its development as a natural antioxidant.

Yam used in the present invention is rich in mucus, and contains a variety of amino acids such as arginine and various nutrients such as sugars, nourishing tonic action in herbal medicine to protect the body, enhance energy, and strengthen muscles. Digestive enzymes such as amylase are included to help digestion, supply sperm to respiratory mucosa, relieve senile age, and effective for expectoration.

Yam has been shown to reduce fat metabolism and muscle glycolysis (Glycolysis), lowering insulin resistance. In addition, the inclusion of Sapogenin and Diosgenin relatively alleviates the dominant action of estrogens, improves hormone imbalance, helps normalize blood sugar levels, and normalizes thyroid hormone function. Prevent the development of type diabetes.

Edible snail used in the present invention may include an edible snail extract enzyme-treated edible snail, may be treated with beta-galactosidase (β-Galactosidase).

Edible snail is a mollusk belonging to the hexagon, scientific name Achatina Fulica. It is surrounded by a spiral shell and has been used for food and medicine because of its excellent functionality. Carbohydrase is included in the digestive fluid of the snail, and it contains enzymes such as cellulase, beta-galactosidase, and chitinase. It is highly applicable as a development material.

According to the herbaceous tree (本草綱目) edible snail is used as a blood pressure lowering agent and diuretic, used as a treatment for laryngitis, surgically used for boils and dermatitis. In addition, it is rich in calcium, potassium and magnesium, and the essential amino acid content accounts for 45% of the total amino acids, which is a balanced protein source.

Beta-galactosidase among the enzymes included in edible snails is an enzyme that hydrolyzes β-D-galactose bonds in which D-galactose and alcohol are bound, and has D-galactose and β-D-galacttoside bonds. Hydrolyze the aligosaccharides present. Beta-galactosidase is an enzyme that has not only hydrolysis but also a metabolic reaction, which is optimal at pH 3.0, is unstable in heat, and is present in the flesh of peaches, apricots and apples in plants. Enzymes that promote the softening of the cell wall by decomposing β-1,4-galactan or arabino galactan, which are side chain bonds of hemicellulose to be. Its activity increases during maturation and softening of fruits.

Water-soluble dietary fiber and complex oligosaccharides prepared using edible snails are not degraded by digestive enzymes, but reach the large intestine to promote the growth of bifidus, an intestinal useful bacterium, to normalize the intestinal bacteria and to cause cavities (Glucan). ) Has the effect of inhibiting the synthesis of insulin, which does not affect insulin secretion.

Ginkgo biloba extract used in the present invention may contain 20 to 30wt% flavonoids.

Ginkgo biloba has been used in oriental medicine for thousands of years, especially as a treatment for heart and lung diseases. In 1965, Ginkgo Biloba extract has been reported for its effects on the treatment of circulatory disorders, cerebrovascular diseases, etc., and has been developed and sold as a medicinal herb.

Ginkgo biloba extract contains 4 to 8 wt% Terpene Lactones in addition to 20 to 30 wt% flavonoids. In the cardiovascular system, there is a function of inhibiting platelet aggregation to increase blood flow and increase cerebral blood volume. At this time, aggregation of platelets is inhibited by Ginkgolide-B, which acts on the antagonism of platelet synthesis factors.

Ginkgo biloba extract also has antioxidant activity, its function directly eliminates free radicals and reactive oxygen species, and inhibits the development of vascular diseases. For example, it is effective in diabetic retinopathy. Ginkgo biloba extract improves insulin resistance, reduces lipid peroxide caused by oxidative stress, lowers triglyceride levels, and increases HDL-cholesterol.

Ginkgo biloba extracts include Amentoflavone, Apigenin, β-Carotene, Bilobalide, Tannin, Amino Acid, Calcium, Iron, Magnesium, Manganese, Zinc, Phosphorus , Vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5 and vitamin C and the like.

The cocoon protein hydrolyzate used in the present invention may include an enzymatic hydrolyzate or an acid hydrolyzate.

Silk produced from silkworms is composed of fibroin, a fibrous protein, and sericin, a rubbery protein to which it is attached.Amino acid content is 40 to 50wt% of glycine and 25 to 35wt% of alanine. Serine (Serine) 10-15wt% and tyrosine (Tyrosine) 3-7wt%, etc., the major amino acids occupy more than 90wt%. This facilitates digestion and absorption through acid, alkali or enzymatic hydrolysis.

The biological activities of cocoon protein hydrolyzate include alcohol metabolism promotion, hypoglycemia, blood cholesterol lowering action and anti-dementia, which are currently applied to functional plants, cosmetics and pharmaceuticals.

In particular, it has been found to have a close effect on leptin hormone, which is associated with obesity-type diabetes. Leptin is a hormone produced and secreted by fat cells and is an appetite regulator that stimulates the satiety center.

Increasing the amount of body fat and the concentration of insulin in the serum increases proportionally, it is more effective for obesity-type diabetes. The cocoon acid hydrolyzate is high and the specific arginine content, the glycine content is here bar the relatively lower reported, NO ^- to help create promotion and activity is possible for prevention and healing of diabetic complications caused by cancer efficacy and hyperglycemia .

L-lysine used in the present invention is an essential amino acid, acts as an energy source, is also a carnitine precursor, and is an amino acid necessary for the synthesis of proteins. It affects the development and growth of children, promotes calcium absorption and improves concentration. It combines collagen with vitamin C and has excellent wound healing after surgery. In herpes simplex, antiviral action.

Insufficient hair loss, lack of energy, loss of appetite, weight loss and poor growth may occur. Foods containing this include cheese, milk, potatoes, meat, soy milk, eggs and fish, especially bitter buckwheat. It is contained. However, excessive intake can give a strain to the kidneys.

The herbal composition according to the present invention is based on 100 parts by weight of black garlic, 62.5 to 850 parts by weight, yam is 75 to 1200 parts by weight, edible snails are 250 to 2500 parts by weight, cocoon protein hydrolyzate is 0.375 to 4.5 parts by weight , Ginkgo biloba extract is 7.5 to 200 parts by weight and L- lysine may be 0.0075 to 0.4 parts by weight, but is not limited thereto.

The herbal composition prepared by the above-mentioned composition ratio contains balanced nutrients, has a preventive and therapeutic effect on diabetes, increases blood vessel damage and increases pancreatic insulin secretion against diabetic complications, and is superior to immune strengthening. It is effective.

The herbal composition according to the present invention may further include vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, arginine, glutathione and apple juice, It may further include, but is not limited to, at least one additive selected from the group consisting of wood vinegar, propolis and aromas.

Here, vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, arginine and glutathione are recommended based on the daily dose of the herbal composition according to the present invention. It may be to include.

As the recommended daily amount of each ingredient, 2000 to 10000 mg of vitamin C, 1 to 100 mg of vitamin B1, 1 to 100 mg of vitamin B2, 1 to 100 mg of vitamin B3, 100 to 500 mg of vitamin B5, 1 to 100 mg of vitamin B6, vitamin 100 to 400 μg of B12, 10 to 100 mg of zinc, 300 to 500 mg of magnesium, 50 to 100 mg of betaine, 500 to 1000 mg of arginine and 500 to 1000 mg of glutathione.

In addition, the apple juice used in the present invention may be prepared only from apple seeds and apple peel, and serves to control the sugar content of the herbal composition. In addition, wood vinegar, propolis and aromas used as additives serve as preservatives.

1 is a flow chart according to the preparation method of the herbal composition having a hypoglycemic effect according to an embodiment of the present invention.

In step S10, black garlic, bitter gourd and yam are added to the ethanol aqueous solution, and then aged. More specifically, black garlic, bitter gourd and yam are immersed in an ethanol aqueous solution and then aged for 2 weeks or more under conditions of 0 to 5 ° C.

The ethanol aqueous solution used herein may include 30 to 65 wt% of distilled water and 35 to 70 wt% of ethanol prepared by distilling raw ore. Ethanol acts as a solvent.

Subsequently, in step S20, after adding the ginkgo leaf extract and edible snail to the mixture prepared in step S10, it is aged. More specifically, after adding the ginkgo leaf extract and edible snail extract to the supernatant of the mixture aged in step S10, it is aged for 2 weeks or more under conditions of 0 to 5 ℃.

Subsequently, in step S30, el-lysine is added to the mixture prepared in step S20, and then aged. More specifically, after the addition of L-lysine to the supernatant of the mixture aged in S20 step, it is aged for 2 weeks or more under conditions of 0 to 5 ℃.

Here, vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, arginine, glutathione and apple juice in addition to L-lysine in the supernatant of the mixture aged in step S20. More may be added.

Subsequently, in step S40, the cocoon protein hydrolyzate is added to the mixture prepared in step S30, and then aged. More specifically, after the cocoon protein hydrolyzate is added to the supernatant of the mixture aged in step S30, it is aged for 2 weeks or more under conditions of 0 to 5 ℃.

Here, after the step S40, after adding at least one or more additives selected from the group consisting of wood vinegar, propolis and fragrance, may further comprise a fifth aging step of aging under conditions of 0 to 5 ℃.

Subsequently, in step S50, the ethanol component of the mixture prepared in step S40 is volatilized and removed to obtain a liquid herbal composition.

After step S50, the obtained liquid herbal composition is sterilized by boiling water for 0.5 to 1 hour under conditions of 80 to 90 ℃, or 0.5 to 1 hours under conditions of 100 to 110 ℃ using an autoclave It may further comprise the step of heat treatment.

And the obtained liquid herbal composition can be filled and packed in a vinyl polyethylene or plastic polyethylene container.

In addition, the crude liquid composition obtained under reduced pressure, heating and drying may be further performed to prepare the herbal composition in the form of a solid powder.

Claims (8)

A herbal composition comprising black garlic, bitter gourd, yam, edible snail, cocoon protein hydrolyzate, ginkgo leaf extract, and L-lysine. The method of claim 1,
Based on 100 parts by weight of the black garlic, 62.5 to 850 parts by weight of the gourd, 75 to 1200 parts by weight of the yam, 250 to 2500 parts by weight of the edible snail, 0.375 to 4.5 parts by weight of the cocoon protein hydrolyzate, Herbal extract of ginkgo biloba extract is 7.5 to 200 parts by weight and the L- lysine is 0.0075 to 0.4 parts by weight. The method of claim 1,
Further includes vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, arginine, glutathione and apple juice,
Herbal medicine, propolis and herbal medicine composition characterized in that it further comprises at least one additive selected from the group consisting of aroma. A first aging step of adding black garlic, bitter melon and yam to an ethanol aqueous solution and then aging at 0 to 5 ° C .;
Adding a ginkgo leaf extract and an edible snail to the supernatant of the mixture prepared in the first aging step, followed by a second aging step of aging under conditions of 0 to 5 ° C .;
A third aging step of adding el-lysine to the supernatant of the mixture prepared in the second aging step, and then aging at 0 to 5 ° C .;
Adding a cocoon protein hydrolyzate to the supernatant of the mixture prepared in the third aging step, followed by a fourth aging step of aging at 0 to 5 ° C .; And
Ethanol removal step of volatilizing and removing the ethanol component of the mixture prepared in the fourth aging step to obtain a liquid herbal composition;
Method for producing a liquid herbal composition comprising a. The method of claim 4, wherein in the third aging step,
Vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, zinc, magnesium, betaine, arginine, glutathione and apple juice are further added to the supernatant of the mixture prepared in the second aging step. Method for producing a liquid herbal composition, characterized in that. The method of claim 4, wherein in the fourth aging step,
After further adding at least one additive selected from the group consisting of wood vinegar, propolis and fragrance, the method of producing a liquid herbal composition further comprises a fifth aging step of aging at 0 to 5 ℃ conditions . According to claim 4, After the ethanol removal step,
The liquid herbal composition is sterilized by boiling in 0.5 to 1 hour under conditions of 80 to 90 ℃,
Heat treatment at 100 to 110 ° C. using an autoclave for 0.5 to 1 hour;
Method for producing a liquid herbal composition, characterized in that it further comprises. 8. The method according to any one of claims 4 to 7,
Decompressing, heating and drying the obtained liquid herbal composition;
Method of producing a herbal composition in the form of a solid powder further comprising.

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