CN101780119B - Cordyceps militaris and Agaricus blazei medicated wine and preparation method thereof - Google Patents
Cordyceps militaris and Agaricus blazei medicated wine and preparation method thereof Download PDFInfo
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- CN101780119B CN101780119B CN2010101385465A CN201010138546A CN101780119B CN 101780119 B CN101780119 B CN 101780119B CN 2010101385465 A CN2010101385465 A CN 2010101385465A CN 201010138546 A CN201010138546 A CN 201010138546A CN 101780119 B CN101780119 B CN 101780119B
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Abstract
The invention provides a Cordyceps militaris and Agaricus blazei medicated wine which is prepared from the following raw materials in parts by weight: 1 part of Cordyceps militaris, 0.1-0.5 part of Agaricus blazei and 5-10 parts of wine the concentration of which is higher than 50%. The invention also provides a preparation method of the medicated wine. The invention takes Cordyceps militaris and Agaricus blazei which are pharmaceutical/food resource fungi as raw materials, can improve the autoimmunity function, enhances the anti-disease capacity, performing the efficacies of preventing cold, and the like, and is a good auxiliary health food in the treating and recovering processes of patients with various tumors and cancer, such as liver cancer, lung cancer, stomach cancer, leukaemia and the like. The invention introduces modern biological technology and method in the pretreating process of raw materials, and by carrying out enzymolysis and freeze thawing treatment on the raw materials, not only improves the dissolution efficiency of the raw materials in a soaking process and shortens the soaking time, but also enables the raw materials to generate physiological biochemical reaction in the pretreating process to generate new components and improves the product quality.
Description
Technical field
The present invention relates to a kind ofly can improve autoimmune function, strengthen the healthy medicated wine of resistance against diseases, specifically, relating to a kind of is the Chinese medicine medicated wine of raw material with Cordyceps militaris (L.) Link., Agaricus blazei Murrill.
Background technology
Medicated wine is the treasured in the Chinese medicine treasure-house, and it can be used as aftercare and the daily use of drinking, and has the effect of health care, beauty treatment skin moistening, preventing and treating diseases.Characteristics such as medicated wine has wide accommodation, be convenient to take, absorb rapidly, can effectively grasp dosage, instant effect, curative effect height, easy storing, people are taken like a shot.And medicated wine can produce different effects according to the difference of its fill a prescription difference and compound method.
Had big quantity research to show that the chemical constituent of tame Cordyceps militaris (L.) Link. and pharmacological action are similar with Cordyceps at present, but price is well below Cordyceps, therefore, the Application and Development of Cordyceps militaris (L.) Link. has great potential market.Prove that after deliberation Cordyceps militaris (L.) Link. has antiviral, antitumor, resisting fatigue, treatment arrhythmia, increase immunity, adjusting and effects such as reduction hyperlipidemia, the liver protecting function.
Agaricus blazei Murrill (Agaricus blazei) has another name called Brazilian mushroom, is a kind of large-scale saprophytic fungus of eating the medicine dual-purpose.Agaricus blazei Murrill has brain-strengthening, antiinflammatory, kidney tonifying, blood sugar lowering, improves diabetes, cholesterol reducing, improves effects such as arteriosclerosis, can be used for suppressing tumor (especially ehrlich ascites carcinoma), medical hemorrhoid complicated by anal fistula, strengthens energy, prevents and treats cardiovascular disease etc.
The present invention is a raw material with these the two kinds funguses of treasuring food medicine dual-purpose, cooperates a kind of varieties of medicinal liquor compound method production Cordyceps militaris and Agaricus blazei medicated wine, and this method can make the effective ingredient stripping to greatest extent of raw material.
Summary of the invention
The object of the present invention is to provide and a kind ofly can improve autoimmune function, strengthen the medicated wine of resistance against diseases, it is that raw material is processed with Cordyceps militaris (L.) Link., Agaricus blazei Murrill.
Another object of the present invention is to provide the method for preparing of said medicated wine.
In order to realize the object of the invention, Cordyceps militaris and Agaricus blazei medicated wine of the present invention, its raw material by following weight portion is processed: 1 part of Cordyceps militaris (L.) Link., 0.1～0.5 part of Agaricus blazei Murrill, 5～10 parts of the above wine of 50 degree.
Preferably 0.2 part of 1 part of Cordyceps militaris (L.) Link., Agaricus blazei Murrill, 8 parts of the above wine of 50 degree.
Cordyceps militaris and Agaricus blazei medicated wine of the present invention adopts following method preparation: with Cordyceps militaris (L.) Link. and Agaricus blazei Murrill section, and freeze thawing after enzymolysis, drying then, and then dry, at last with the above steeping in wine bubble of 50 degree.
The fungus that medicated wine of the present invention is treasured food medicine dual-purpose with two kinds of Cordyceps militaris (L.) Link., Agaricus blazei Murrill etc. is a raw material; Can produce good synergism; Can improve autoimmune function, strengthen resistance against diseases, play effects such as preventing cold; And it also plays auxiliary health-care effect to kinds of tumors such as hepatocarcinoma, pulmonary carcinoma, gastric cancer, leukemia and cancer patient in treatment and rehabilitation course, improve life quality.
The method for preparing of Cordyceps militaris and Agaricus blazei medicated wine of the present invention comprises the steps:
1) section: Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are cut into the section that thickness is 2～3mm respectively, mix then;
2) enzymolysis: according to the unit of activity of variety classes enzyme, be mixed with the enzymolysis solution of best enzyme activity concentration, the raw material section that step 1) is obtained joins in the enzymolysis solution enzymolysis 1～2h;
Said enzyme is one or more in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease;
3) drying: the mixture behind the enzymolysis is dry under 80 ℃ of temperature,, water content stops drying when being reduced to 50%～60% (weight), be cooled to room temperature;
4) freeze thawing:, at room temperature thaw naturally then to room temperature with above-mentioned dried mixture under-60～-20 ℃ of temperature freezing 10～20 hours;
5) drying: the mixture that will return to room temperature is dry under 80 ℃ of temperature once more, when water content is reduced to 20%～30%, stops drying, is cooled to room temperature;
6) soak: the dried mixture of step 5) is steeped with the above steeping in wine of 50 degree.
Wherein, the raw material section is 1: 3～5 with the weight ratio of enzymolysis solution step 2).Hydrolysis temperature is selected the optimum activity temperature or the average optimum activity temperature of compound enzyme (two or more enzyme) of single enzyme.
Soak time in the step 6) is 10～30 days.Specifically, soak time can suitably be regulated according to the height of temperature, when temperature more than 20 ℃ the time, soak time is preferably 10～15 days; When temperature during at 10～20 ℃, soak time is preferably 20～30 days.
Especially, if be raw material, before with the raw material section,, and then cut into slices so earlier with fresh Cordyceps militaris (L.) Link. and Agaricus blazei Murrill freezing 8～24h under-4～-10 ℃ of temperature with the fresh Cordyceps militaris (L.) Link. and the Agaricus blazei Murrill of freshly harvested.Since section more easily after bright article are freezing, and the cross section under the freezing state is big and complete, contact surface is big during enzymolysis, and hydrolysis result is better.
If be raw material with exsiccant Cordyceps militaris (L.) Link. and Agaricus blazei Murrill, can directly cut into slices, and after section, it fully mixed with enzymolysis solution, making its rehydration to water content is 50%～60% (weight), carries out enzymolysis simultaneously.If there is not rehydration, the substrate of enzyme under can't the enzymolysis drying regime.
The present invention adopts microtome that raw material is cut into slices, and is broken end but must guard against strand; If strand then can cause leachate muddy for broken end, messenger drug colours of wine and mouthfeel variation.
Medicated wine of the present invention is raw material with Cordyceps militaris (L.) Link. and Agaricus blazei Murrill; Because Cordyceps militaris (L.) Link. and Agaricus blazei Murrill all belong to fungus; Its cell wall has stopped the stripping of effective ingredient to a certain extent, therefore, if with traditional medicated wine method for preparing preparation; Then the dissolution rate of effective ingredient is not high, needs long-time soak (soak time is generally 50～60 days).In order to improve dissolution rate; The present invention carries out pretreatment through modern biological enzymolysis technology to raw material; Through making the multiple enzyme of fungus breaking cellular wall; Like in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease etc. one or more, the cell wall of these two kinds of funguses of Cordyceps militaris (L.) Link. and Agaricus blazei Murrill is degraded under the enzyme effect, hydrolysis temperature is selected the optimum activity temperature or the average optimum activity temperature of compound enzyme (two or more enzyme) of single enzyme; Through freeze thawing treatment, thoroughly destroy the cell wall structure of Cordyceps militaris (L.) Link. and Agaricus blazei Murrill again, made farthest stripping of effective ingredient, improved dissolution rate, shortened soak time.
In addition, because the solvable effective ingredient stripping of part has been arranged in enzymolysis process, the enzymolysis solution that therefore directly will be mixed with raw material carries out drying.
The present invention selects to use the above wine of 50 degree (Chinese liquor or yellow wine all can) to use wine as soaking; This is because the above wine of 50 degree can kill antibacterial and harmful microorganism, parasite and the worm's ovum etc. that attach in the Chinese herbal medicine to a great extent in the process of soaking, and makes it under safety condition, to drink.In addition, the concentration of medicated wine and mouthfeel can blend, prepare according to traditional method after soak completion.
The container of steeping in wine among the present invention preferably uses vial or crock etc., can not use canister, in order to avoid metal effusion noxious substance or toxigenicity chemical reaction in immersion process.After soaking completion, get limpid supernatant and be distributed into finished product; Medicinal residues and muddy part can be separated through methods such as centrifugal or filtrations.
The invention has the advantages that:
1, the present invention is a raw material with the fungus of Cordyceps militaris (L.) Link. and two kinds of food and medicament dual-purposes of Agaricus blazei Murrill, can produce synergism, can improve autoimmune function, strengthens resistance against diseases, plays effects such as preventing cold; And be kinds of tumors and the excellent auxiliary health foods of cancer patient in treatment and rehabilitation course such as hepatocarcinoma, pulmonary carcinoma, gastric cancer, leukemia;
2, the present invention utilizes modern biotechnology and methods such as enzymolysis, freeze thawing treatment; Destroyed the cell wall structure of Cordyceps militaris (L.) Link. and Agaricus blazei Murrill; Make farthest stripping of effective ingredient, shortened soak time, and make raw material that biochemical reactions take place in preprocessing process; Produce new component, improved product quality; Compare with the medicated wine of traditional method preparation, darker from seeing color in appearance, show that leachable obviously increases, in addition, mouthfeel is more mellow.
The specific embodiment
Embodiment 1
Prescription: the cordyceps fresh article 100g of freshly harvested, the agaricus brasiliensis fresh article 20g of freshly harvested, 52 degree Chinese liquor 800g.
Method for preparing:
1) with fresh Cordyceps militaris (L.) Link. and Agaricus blazei Murrill freezing 16h under-4 ℃ of temperature, use microtome to be cut into the section of thickness respectively then, must guard against strand and be broken end as 2mm, subsequent use after mixing;
2) the Limax digestive enzyme being configured to concentration expressed in percentage by weight is 0.5% enzymolysis solution 360g, adds the section that step 1) obtains then, at 40 ℃ of enzymolysis 2h;
3) raw material behind the enzymolysis is put into baking oven together with enzymolysis solution, dry under 80 ℃ of temperature,, the mixture water content stops drying when being reduced to 60% (weight), be cooled to room temperature;
4) above-mentioned dried mixture is put into cryogenic refrigerator, freezing 20h under-60 ℃ of temperature at room temperature thaws to room temperature then naturally;
The mixture that 5) will return to room temperature is put into baking oven once more, and is dry under 80 ℃ of temperature, when water content is reduced to 30% (weight), stops drying, is cooled to room temperature;
6) add then 52 the degree Chinese liquor, soak 10 days (temperature during immersion is 25 ℃) drinkable.
Embodiment 2
Prescription: Cordyceps militaris (L.) Link. dry product 100g, Agaricus blazei Murrill dry product 50g, 52 degree Chinese liquor 1000g.
Method for preparing:
1) Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are done is used microtome to be cut into the section of thickness respectively, must guard against strand and be broken end as 2mm, subsequent use after mixing;
2) papain is configured to the enzymolysis solution 500g of concentration expressed in percentage by weight 0.6%, adds the section that step 1) obtains then, at 60 ℃ of enzymolysis 2h;
3) raw material behind the enzymolysis is put into baking oven together with enzymolysis solution, dry under 80 ℃ of temperature,, water content stops drying when being reduced to 50% (weight), be cooled to room temperature;
4) above-mentioned dried mixture is put into cryogenic refrigerator, freezing 10h under-50 ℃ of temperature at room temperature thaws to room temperature then naturally;
The mixture that 5) will return to room temperature is put into baking oven once more, and is dry under 80 ℃ of temperature, when water content is reduced to 30%, stops drying, is cooled to room temperature;
6) add then 52 the degree Chinese liquor, soak 15 days (temperature during immersion is 25 ℃) drinkable.
Embodiment 3
Prescription: Cordyceps militaris (L.) Link. dry product 100g, Agaricus blazei Murrill dry product 10g, 65 degree Chinese liquor 500g.
Method for preparing:
1) use microtome to be cut into the section of thickness respectively Cordyceps militaris (L.) Link. and Agaricus blazei Murrill dry product, must guard against strand and be broken end as 2mm, subsequent use after mixing;
2) Limax digestive enzyme and cellulase are configured to concentration expressed in percentage by weight and are 0.5% complex enzyme hydrolysis liquid 500g, add the section that step 1) obtains then, at 55 ℃ of enzymolysis 2h;
3) raw material behind the enzymolysis is put into baking oven together with enzymolysis solution, dry under 80 ℃ of temperature,, water content stops drying when being reduced to 60% (weight), be cooled to room temperature;
4) above-mentioned dried mixture is put into cryogenic refrigerator, freezing 20h under-20 ℃ of temperature at room temperature thaws to room temperature then naturally;
The mixture that 5) will return to room temperature is put into baking oven once more, and is dry under 80 ℃ of temperature, when water content is reduced to 30% (weight), stops drying, is cooled to room temperature;
6) add then 65 the degree Chinese liquor, soak 10 days (temperature during immersion is 25 ℃) drinkable.
Though; The present invention has been done detailed description in the preceding text with general explanation and specific embodiments; But on basis of the present invention, the those of ordinary skill in affiliated field can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (7)
1. a Cordyceps militaris and Agaricus blazei medicated wine is characterized in that, its raw material by following weight portion is processed: 1 part of Cordyceps militaris (L.) Link., 0.1～0.5 part of Agaricus blazei Murrill, 5～10 parts of the above wine of 50 degree; It specifically is the method for preparing preparation by following sequential steps:
1) section: Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are cut into the section that thickness is 2～3mm respectively, mix then;
2) enzymolysis: according to the unit of activity of variety classes enzyme, be mixed with the enzymolysis solution of best enzyme activity concentration, the raw material section that step 1) is obtained joins in the enzymolysis solution enzymolysis 1～2h;
Said enzyme is one or more in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease;
3) drying: the mixture behind the enzymolysis is dry under 80 ℃ of temperature,, water content stops drying when being reduced to 50%～60% (weight), be cooled to room temperature;
4) freeze thawing:, at room temperature thaw naturally then to room temperature with above-mentioned dried mixture under-60～-20 ℃ of temperature freezing 10～20 hours;
5) drying: the mixture that will return to room temperature is dry under 80 ℃ of temperature once more, when water content is reduced to 20%～30% (weight), stops drying, is cooled to room temperature;
6) soak: the dried mixture of step 5) is steeped with the above steeping in wine of 50 degree.
2. medicated wine according to claim 1 is characterized in that, its raw material by following weight portion is processed: 1 part of Cordyceps militaris (L.) Link., 0.2 part of Agaricus blazei Murrill, 8 parts of the above wine of 50 degree.
3. prepare the method for claim 1 or 2 said medicated wine, it is characterized in that, comprise the steps:
1) section: Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are cut into the section that thickness is 2～3mm respectively, mix then;
2) enzymolysis: according to the unit of activity of variety classes enzyme, be mixed with the enzymolysis solution of best enzyme activity concentration, the raw material section that step 1) is obtained joins in the enzymolysis solution enzymolysis 1～2h;
Said enzyme is one or more in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease;
3) drying: the mixture behind the enzymolysis is dry under 80 ℃ of temperature,, water content stops drying when being reduced to 50%～60% (weight), be cooled to room temperature;
4) freeze thawing:, at room temperature thaw naturally then to room temperature with above-mentioned dried mixture under-60～-20 ℃ of temperature freezing 10～20 hours;
5) drying: the mixture that will return to room temperature is dry under 80 ℃ of temperature once more, when water content is reduced to 20%～30% (weight), stops drying, is cooled to room temperature;
6) soak: the dried mixture of step 5) is steeped with the above steeping in wine of 50 degree.
4. method for preparing according to claim 3 is characterized in that step 2) middle raw material is cut into slices and the weight ratio of enzymolysis solution is 1: 3～5.
5. method for preparing according to claim 3 is characterized in that, soak time is 10～30 days in the step 6).
6. method for preparing according to claim 3 is characterized in that, first Cordyceps militaris (L.) Link. and Agaricus blazei Murrill freezing 8～24h under-4～-10 ℃ of temperature with freshly harvested, and then cut into slices.
7. method for preparing according to claim 3 is characterized in that, after the section of exsiccant Cordyceps militaris (L.) Link. and Agaricus blazei Murrill, with step 2) in enzymolysis solution fully mix, making its rehydration to water content is 50%～60% (weight), carries out enzymolysis simultaneously.
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| CN104432362A (en) * | 2013-09-16 | 2015-03-25 | 苏坚宏 | Cordyceps militaris and Agaricus blazei beverage and preparation method thereof |
| CN104644767A (en) * | 2014-12-04 | 2015-05-27 | 郭士平 | Medicine for tonifying kidney, protecting calcium and preventing osteoporosis and preparation process thereof |
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| CN105886288A (en) * | 2016-06-06 | 2016-08-24 | 孙立民 | Agaricus blazei murill healthcare liquor and preparation method thereof |
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| CN108208811A (en) * | 2018-01-29 | 2018-06-29 | 江苏阜丰生物科技有限公司 | A kind of preparation method of Cordyceps militaris pectase |
| CN108165434A (en) * | 2018-02-28 | 2018-06-15 | 普安县应宏酒厂 | It is a kind of to accelerate to reduce thorn pear wine of blood fat and preparation method thereof |
| CN111073785A (en) * | 2019-12-04 | 2020-04-28 | 泸州品创科技有限公司 | Cordyceps militaris health wine and preparation method and application thereof |
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