CN101780119A - Cordyceps militaris and Agaricus blazei medicated wine and preparation method thereof - Google Patents
Cordyceps militaris and Agaricus blazei medicated wine and preparation method thereof Download PDFInfo
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- CN101780119A CN101780119A CN 201010138546 CN201010138546A CN101780119A CN 101780119 A CN101780119 A CN 101780119A CN 201010138546 CN201010138546 CN 201010138546 CN 201010138546 A CN201010138546 A CN 201010138546A CN 101780119 A CN101780119 A CN 101780119A
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Abstract
The invention provides a Cordyceps militaris and Agaricus blazei medicated wine which is prepared from the following raw materials in parts by weight: 1 part of Cordyceps militaris, 0.1-0.5 part of Agaricus blazei and 5-10 parts of wine the concentration of which is higher than 50%. The invention also provides a preparation method of the medicated wine. The invention takes Cordyceps militaris and Agaricus blazei which are pharmaceutical/food resource fungi as raw materials, can improve the autoimmunity function, enhances the anti-disease capacity, performing the efficacies of preventing cold, and the like, and is a good auxiliary health food in the treating and recovering processes of patients with various tumors and cancer, such as liver cancer, lung cancer, stomach cancer, leukaemia and the like. The invention introduces modern biological technology and method in the pretreating process of raw materials, and by carrying out enzymolysis and freeze thawing treatment on the raw materials, not only improves the dissolution efficiency of the raw materials in a soaking process and shortens the soaking time, but also enables the raw materials to generate physiological biochemical reaction in the pretreating process to generate new components and improves the product quality.
Description
Technical field
The present invention relates to a kind ofly can improve autoimmune function, strengthen the healthy medicated wine of resistance against diseases, specifically, relating to a kind of is the Chinese medicine medicated wine of raw material with Cordyceps militaris (L.) Link., Agaricus blazei Murrill.
Background technology
Medicated wine is the treasured in the Chinese medicine treasure-house, and it can be used as aftercare and the daily use of drinking, and has the effect of health care, beauty treatment skin moistening, preventing and treating diseases.Characteristics such as medicated wine has wide accommodation, be convenient to take, absorb rapidly, can effectively grasp dosage, instant effect, curative effect height, preserve easily, people take like a shot.And medicated wine can produce different effects according to the difference of its fill a prescription difference and compound method.
Had in a large number at present to studies show that the chemical constituent of tame Cordyceps militaris (L.) Link. and pharmacological action are similar to Cordyceps, but price is well below Cordyceps, therefore, the Application and Development of Cordyceps militaris (L.) Link. has great potential market.Prove that after deliberation Cordyceps militaris (L.) Link. has antiviral, antitumor, resisting fatigue, treatment arrhythmia, increase immunity, adjusting and effects such as reduction hyperlipidemia, the liver protecting function.
Agaricus blazei Murrill (Agaricus blazei) has another name called Brazilian mushroom, is a kind of large-scale saprophytic fungus of eating the medicine dual-purpose.Agaricus blazei Murrill has brain-strengthening, antiinflammatory, kidney tonifying, blood sugar lowering, improves diabetes, cholesterol reducing, improves effects such as arteriosclerosis, can be used for suppressing tumor (especially ehrlich ascites carcinoma), medical hemorrhoid complicated by anal fistula, strengthens energy, prevents and treats cardiovascular disease etc.
The present invention is a raw material with these the two kinds funguses of treasuring food medicine dual-purpose, cooperates a kind of varieties of medicinal liquor compound method production Cordyceps militaris and Agaricus blazei medicated wine, and this method can make the effective ingredient stripping to greatest extent of raw material.
Summary of the invention
The object of the present invention is to provide and a kind ofly can improve autoimmune function, strengthen the medicated wine of resistance against diseases, it is that raw material is made with Cordyceps militaris (L.) Link., Agaricus blazei Murrill.
Another object of the present invention is to provide the preparation method of described medicated wine.
In order to realize purpose of the present invention, Cordyceps militaris and Agaricus blazei medicated wine of the present invention, its raw material by following weight portion is made: 1 part of Cordyceps militaris (L.) Link., 0.1～0.5 part of Agaricus blazei Murrill, 5～10 parts of the above wine of 50 degree.
Preferably 0.2 part of 1 part of Cordyceps militaris (L.) Link., Agaricus blazei Murrill, 8 parts of the above wine of 50 degree.
Cordyceps militaris and Agaricus blazei medicated wine of the present invention adopts following method preparation: with Cordyceps militaris (L.) Link. and Agaricus blazei Murrill section, and freeze thawing after enzymolysis, drying then, and then dry, at last with the above steeping in wine bubble of 50 degree.
The fungus that medicated wine of the present invention is treasured food medicine dual-purpose with two kinds of Cordyceps militaris (L.) Link., Agaricus blazei Murrill etc. is a raw material, can produce good synergism, can improve autoimmune function, strengthen resistance against diseases, play effects such as preventing cold, and it also plays auxiliary health-care effect to kinds of tumors such as hepatocarcinoma, pulmonary carcinoma, gastric cancer, leukemia and cancer patient in treatment and rehabilitation course, improve life quality.
The preparation method of Cordyceps militaris and Agaricus blazei medicated wine of the present invention comprises the steps:
1) section: Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are cut into the section that thickness is 2～3mm respectively, mix then;
2) enzymolysis: according to the unit of activity of variety classes enzyme, be mixed with the enzymolysis solution of best enzyme activity concentration, the raw material section that step 1) is obtained joins in the enzymolysis solution enzymolysis 1～2h;
Described enzyme is one or more in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease;
3) drying: the mixture behind the enzymolysis is dry under 80 ℃ of temperature, when being reduced to 50%～60% (weight), water content stops drying, be cooled to room temperature;
4) freeze thawing:, at room temperature thaw naturally then to room temperature with above-mentioned dried mixture under-60～-20 ℃ of temperature freezing 10～20 hours;
5) drying: the mixture that will return to room temperature is dry under 80 ℃ of temperature once more, stops drying when water content is reduced to 20%～30%, is cooled to room temperature;
6) soak: the dried mixture of step 5) is steeped with the above steeping in wine of 50 degree.
Wherein, the raw material section is 1: 3～5 with the weight ratio of enzymolysis solution step 2).Hydrolysis temperature is selected the optimum activity temperature or the average optimum activity temperature of compound enzyme (two or more enzyme) of single enzyme.
Soak time in the step 6) is 10～30 days.Specifically, soak time can suitably be regulated according to the height of temperature, when temperature more than 20 ℃ the time, soak time is preferably 10～15 days; When temperature during at 10～20 ℃, soak time is preferably 20～30 days.
Especially, if be raw material with the fresh Cordyceps militaris (L.) Link. and the Agaricus blazei Murrill of freshly harvested, so before with the raw material section, freezing 8～24h under-4～-10 ℃ of temperature with fresh Cordyceps militaris (L.) Link. and Agaricus blazei Murrill earlier, and then cut into slices.Since easier section after bright product are freezing, and the cross section under the freezing state is big and complete, contact surface is big during enzymolysis, and hydrolysis result is better.
If be raw material with exsiccant Cordyceps militaris (L.) Link. and Agaricus blazei Murrill, can directly cut into slices, and after section, it fully be mixed with enzymolysis solution, making its rehydration to water content is 50%～60% (weight), carries out enzymolysis simultaneously.If there is not rehydration, the substrate of enzyme under can't the enzymolysis drying regime.
The present invention adopts microtome that raw material is cut into slices, and is broken end but must guard against strand; If strand then can cause the leachate muddiness for broken end, messenger drug colours of wine and mouthfeel variation.
Medicated wine of the present invention is raw material with Cordyceps militaris (L.) Link. and Agaricus blazei Murrill, because Cordyceps militaris (L.) Link. and Agaricus blazei Murrill all belong to fungus, its cell wall has stopped the stripping of effective ingredient to a certain extent, therefore, if with traditional medicated wine preparation method preparation, then the dissolution rate of effective ingredient is not high, needs long-time soak (soak time is generally 50～60 days).In order to improve dissolution rate, the present invention carries out pretreatment by modern biological enzymolysis technology to raw material, by making the multiple enzyme of fungus breaking cellular wall, as in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease etc. one or more, the cell wall of these two kinds of funguses of Cordyceps militaris (L.) Link. and Agaricus blazei Murrill is degraded under the enzyme effect, and hydrolysis temperature is selected the optimum activity temperature or the average optimum activity temperature of compound enzyme (two or more enzyme) of single enzyme; By freeze thawing treatment, thoroughly destroy the cell wall structure of Cordyceps militaris (L.) Link. and Agaricus blazei Murrill again, made farthest stripping of effective ingredient, improved dissolution rate, shortened soak time.
In addition, because the solvable effective ingredient stripping of part has been arranged in enzymolysis process, the enzymolysis solution that therefore directly will be mixed with raw material carries out drying.
The present invention selects to use the above wine of 50 degree (Chinese liquor or yellow wine all can) to use wine as soaking, this is because the above wine of 50 degree can kill antibacterial and harmful microorganism, parasite and the worm's ovum etc. that attach in the Chinese herbal medicine to a great extent in the process of soaking, and makes it to drink under safety condition.In addition, the concentration of medicated wine and mouthfeel can blend, prepare according to traditional method after immersion be finished.
The container of steeping in wine among the present invention preferably uses vial or crock etc., can not use canister, in order to avoid metal effusion noxious substance or toxigenicity chemical reaction in immersion process.After immersion is finished, get limpid supernatant and be distributed into finished product; Medicinal residues and muddy part can be separated by methods such as centrifugal or filtrations.
The invention has the advantages that:
1, the present invention is a raw material with the fungus of Cordyceps militaris (L.) Link. and two kinds of food and medicament dual-purposes of Agaricus blazei Murrill, can produce synergism, can improve autoimmune function, strengthens resistance against diseases, plays effects such as preventing cold; And be kinds of tumors and the excellent auxiliary health foods of cancer patient in treatment and rehabilitation course such as hepatocarcinoma, pulmonary carcinoma, gastric cancer, leukemia;
2, the present invention utilizes modern biotechnology and methods such as enzymolysis, freeze thawing treatment, destroyed the cell wall structure of Cordyceps militaris (L.) Link. and Agaricus blazei Murrill, make farthest stripping of effective ingredient, shortened soak time, and make raw material that biochemical reactions take place in preprocessing process, produce new component, improved product quality; Compare with the medicated wine of traditional method preparation, darker from seeing color in appearance, show that leachable obviously increases, in addition, mouthfeel is more mellow.
The specific embodiment
Embodiment 1
Prescription: the cordyceps fresh product 100g of freshly harvested, the agaricus brasiliensis fresh product 20g of freshly harvested, 52 degree Chinese liquor 800g.
Preparation method:
1) the freezing 16h under-4 ℃ of temperature with fresh Cordyceps militaris (L.) Link. and Agaricus blazei Murrill is cut into the section that thickness is 2mm respectively with microtome then, must guard against strand and is broken end, and is standby after mixing;
2) the Limax digestive enzyme being configured to concentration expressed in percentage by weight is 0.5% enzymolysis solution 360g, adds the section that step 1) obtains then, at 40 ℃ of enzymolysis 2h;
3) raw material behind the enzymolysis is put into baking oven together with enzymolysis solution, dry under 80 ℃ of temperature, when being reduced to 60% (weight), the mixture water content stops drying, be cooled to room temperature;
4) above-mentioned dried mixture is put into cryogenic refrigerator, freezing 20h under-60 ℃ of temperature at room temperature thaws then naturally to room temperature;
5) mixture that will return to room temperature is put into baking oven once more, and is dry under 80 ℃ of temperature, stops drying when water content is reduced to 30% (weight), is cooled to room temperature;
6) add then 52 the degree Chinese liquor, soak 10 days (temperature during immersion is 25 ℃) drinkable.
Embodiment 2
Prescription: Cordyceps militaris (L.) Link. dry product 100g, Agaricus blazei Murrill dry product 50g, 52 degree Chinese liquor 1000g.
Preparation method:
1) Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are done be cut into the section that thickness is 2mm respectively with microtome, must guard against strand and be broken end, it is standby to mix the back;
2) papain is configured to the enzymolysis solution 500g of concentration expressed in percentage by weight 0.6%, adds the section that step 1) obtains then, at 60 ℃ of enzymolysis 2h;
3) raw material behind the enzymolysis is put into baking oven together with enzymolysis solution, dry under 80 ℃ of temperature, when being reduced to 50% (weight), water content stops drying, be cooled to room temperature;
4) above-mentioned dried mixture is put into cryogenic refrigerator, freezing 10h under-50 ℃ of temperature at room temperature thaws then naturally to room temperature;
5) mixture that will return to room temperature is put into baking oven once more, and is dry under 80 ℃ of temperature, stops drying when water content is reduced to 30%, is cooled to room temperature;
6) add then 52 the degree Chinese liquor, soak 15 days (temperature during immersion is 25 ℃) drinkable.
Embodiment 3
Prescription: Cordyceps militaris (L.) Link. dry product 100g, Agaricus blazei Murrill dry product 10g, 65 degree Chinese liquor 500g.
Preparation method:
1) Cordyceps militaris (L.) Link. and Agaricus blazei Murrill dry product are cut into the section that thickness is 2mm respectively with microtome, must guard against strand and be broken end, standby after mixing;
2) Limax digestive enzyme and cellulase are configured to concentration expressed in percentage by weight and are 0.5% complex enzyme hydrolysis liquid 500g, add the section that step 1) obtains then, at 55 ℃ of enzymolysis 2h;
3) raw material behind the enzymolysis is put into baking oven together with enzymolysis solution, dry under 80 ℃ of temperature, when being reduced to 60% (weight), water content stops drying, be cooled to room temperature;
4) above-mentioned dried mixture is put into cryogenic refrigerator, freezing 20h under-20 ℃ of temperature at room temperature thaws then naturally to room temperature;
5) mixture that will return to room temperature is put into baking oven once more, and is dry under 80 ℃ of temperature, stops drying when water content is reduced to 30% (weight), is cooled to room temperature;
6) add then 65 the degree Chinese liquor, soak 10 days (temperature during immersion is 25 ℃) drinkable.
Though, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, those of ordinary skill in the field can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. a Cordyceps militaris and Agaricus blazei medicated wine is characterized in that, its raw material by following weight portion is made: 1 part of Cordyceps militaris (L.) Link., 0.1～0.5 part of Agaricus blazei Murrill, 5～10 parts of the above wine of 50 degree.
2. medicated wine according to claim 1 is characterized in that, its raw material by following weight portion is made: 1 part of Cordyceps militaris (L.) Link., 0.2 part of Agaricus blazei Murrill, 8 parts of the above wine of 50 degree.
3. medicated wine according to claim 1 and 2 is characterized in that, described medicated wine adopts following method preparation: with Cordyceps militaris (L.) Link. and Agaricus blazei Murrill section, and freeze thawing after enzymolysis, drying then, and then dry, at last with the above steeping in wine bubble of 50 degree.
4. prepare the method for any described medicated wine of claim 1-3, it is characterized in that, comprise the steps:
1) section: Cordyceps militaris (L.) Link. and Agaricus blazei Murrill are cut into the section that thickness is 2～3mm respectively, mix then;
2) enzymolysis: according to the unit of activity of variety classes enzyme, be mixed with the enzymolysis solution of best enzyme activity concentration, the raw material section that step 1) is obtained joins in the enzymolysis solution enzymolysis 1～2h;
Described enzyme is one or more in Limax digestive enzyme, lywallzyme, cellulase, chitinase or the protease;
3) drying: the mixture behind the enzymolysis is dry under 80 ℃ of temperature, when being reduced to 50%～60% (weight), water content stops drying, be cooled to room temperature;
4) freeze thawing:, at room temperature thaw naturally then to room temperature with above-mentioned dried mixture under-60～-20 ℃ of temperature freezing 10～20 hours;
5) drying: the mixture that will return to room temperature is dry under 80 ℃ of temperature once more, stops drying when water content is reduced to 20%～30% (weight), is cooled to room temperature;
6) soak: the dried mixture of step 5) is steeped with the above steeping in wine of 50 degree.
5. preparation method according to claim 4 is characterized in that step 2) middle raw material is cut into slices and the weight ratio of enzymolysis solution is 1: 3～5.
6. preparation method according to claim 4 is characterized in that, soak time is 10～30 days in the step 6).
7. preparation method according to claim 4 is characterized in that, first Cordyceps militaris (L.) Link. and Agaricus blazei Murrill freezing 8～24h under-4～-10 ℃ of temperature with freshly harvested, and then cut into slices.
8. preparation method according to claim 4 is characterized in that, after the section of exsiccant Cordyceps militaris (L.) Link. and Agaricus blazei Murrill, with step 2) in enzymolysis solution fully mix, making its rehydration to water content is 50%～60% (weight), carries out enzymolysis simultaneously.
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| CN2010101385465A CN101780119B (en) | 2010-03-22 | 2010-03-22 | Cordyceps militaris and Agaricus blazei medicated wine and preparation method thereof |
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| CN2010101385465A CN101780119B (en) | 2010-03-22 | 2010-03-22 | Cordyceps militaris and Agaricus blazei medicated wine and preparation method thereof |
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| CN101780119B CN101780119B (en) | 2012-02-29 |
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| CN102726569A (en) * | 2012-06-21 | 2012-10-17 | 何园素 | Chinese caterpillar fungus tea composition |
| CN102839107A (en) * | 2012-09-20 | 2012-12-26 | 中华全国供销合作总社昆明食用菌研究所 | Preparation method of truffle wine |
| CN102911849A (en) * | 2012-11-16 | 2013-02-06 | 湖北省农业科学院农产品加工与核农技术研究所 | Method for preparing agaricus blazei murrill wine through agaricus blazei murrill liquid fermentation products added with pueraria lobota slag |
| CN102994305A (en) * | 2012-10-17 | 2013-03-27 | 徐州鸿宇农业科技有限公司 | Method for preparing health-care food (therapy) product (nutrient juice wine) by use of extracts from cordyceps militaris and cocoon |
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| CN1462591A (en) * | 2003-06-26 | 2003-12-24 | 薛丽贞 | Food and substrate of cordyceps militatris, and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102726569A (en) * | 2012-06-21 | 2012-10-17 | 何园素 | Chinese caterpillar fungus tea composition |
| CN102839107A (en) * | 2012-09-20 | 2012-12-26 | 中华全国供销合作总社昆明食用菌研究所 | Preparation method of truffle wine |
| CN102994305A (en) * | 2012-10-17 | 2013-03-27 | 徐州鸿宇农业科技有限公司 | Method for preparing health-care food (therapy) product (nutrient juice wine) by use of extracts from cordyceps militaris and cocoon |
| CN102994305B (en) * | 2012-10-17 | 2013-11-06 | 徐州鸿宇农业科技有限公司 | Method for preparing health-care food (therapy) product (nutrient juice wine) by use of extracts from cordyceps militaris and cocoon |
| CN102911849A (en) * | 2012-11-16 | 2013-02-06 | 湖北省农业科学院农产品加工与核农技术研究所 | Method for preparing agaricus blazei murrill wine through agaricus blazei murrill liquid fermentation products added with pueraria lobota slag |
| CN102911849B (en) * | 2012-11-16 | 2013-08-21 | 湖北省农业科学院农产品加工与核农技术研究所 | Method for preparing agaricus blazei murrill wine through agaricus blazei murrill liquid fermentation products added with pueraria lobota slag |
| CN103937646A (en) * | 2013-09-02 | 2014-07-23 | 咸宁市黄道核农科技有限公司 | Agaricus blazei juice wine having sweet-scented osmanthus flavor and preparation method thereof |
| CN104432362A (en) * | 2013-09-16 | 2015-03-25 | 苏坚宏 | Cordyceps militaris and Agaricus blazei beverage and preparation method thereof |
| CN104644767A (en) * | 2014-12-04 | 2015-05-27 | 郭士平 | Medicine for tonifying kidney, protecting calcium and preventing osteoporosis and preparation process thereof |
| CN105707618A (en) * | 2014-12-05 | 2016-06-29 | 钟虹光 | Hericium erinaceus beverage capable of invigorating stomach and nourishing stomach and preparation method of hericium erinaceus beverage |
| CN104606271A (en) * | 2015-02-10 | 2015-05-13 | 吉林大学 | Ginseng antler grass composite preparation for improving immunity |
| CN105886288A (en) * | 2016-06-06 | 2016-08-24 | 孙立民 | Agaricus blazei murill healthcare liquor and preparation method thereof |
| CN106544256A (en) * | 2016-12-22 | 2017-03-29 | 西南林业大学 | A kind of dendrobium officinale health wine and preparation method thereof |
| CN108208811A (en) * | 2018-01-29 | 2018-06-29 | 江苏阜丰生物科技有限公司 | A kind of preparation method of Cordyceps militaris pectase |
| CN108165434A (en) * | 2018-02-28 | 2018-06-15 | 普安县应宏酒厂 | It is a kind of to accelerate to reduce thorn pear wine of blood fat and preparation method thereof |
| CN111073785A (en) * | 2019-12-04 | 2020-04-28 | 泸州品创科技有限公司 | Cordyceps militaris health wine and preparation method and application thereof |
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