CN103705547A - Mythic Fungus spore wall breaking treatment agent - Google Patents
Mythic Fungus spore wall breaking treatment agent Download PDFInfo
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- CN103705547A CN103705547A CN201310674071.5A CN201310674071A CN103705547A CN 103705547 A CN103705547 A CN 103705547A CN 201310674071 A CN201310674071 A CN 201310674071A CN 103705547 A CN103705547 A CN 103705547A
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Abstract
The invention discloses a Mythic Fungus spore wall breaking treatment agent. The Mythic Fungus spore wall breaking treatment agent comprises, by weight, 100 parts of ethanol, 15-20 parts of calcium oxalate, 9-13 parts of cholinesterase, 6-10 parts of glycogen phosphorylase, 5-10 parts of citric acid, 2-5 parts of VE, 0.1-0.5 parts of 1-hydroxyethylidene-1,1-diphosphonic acid, and 0.01-0.5 parts of zinc sulfate. The Mythic Fungus spore wall breaking treatment agent pertinently dissociates the tissues of cell walls according to the structural tissues of Mythic Fungus spores to make the cell walls of the Mythic Fungus spores thoroughly disintegrated under general mechanical wall breaking conditions, so the effective components in the cells can be completely and rapidly released, and the wall breaking rate can reach above 90%. The addition of the VE and calcium oxalate improves the effects of the Mythic Fungus spores.
Description
Technical field
The present invention relates to a kind of plant tissue distintegrant.
Background technology
Ganoderma, property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.According to animal experiment, white mice is had to calmness, analgesic activity.Can improve that white mice is cold-resistant, hypoxia-bearing capability, and postpone its death time.The Ganoderma of take is equipped with the Chinese medicines such as the Rhizoma Atractylodis Macrocephalae, Radix Notoginseng, Rhizoma Chuanxiong as main, can significantly improve the survival rate of animal, and can help animal to tide over radiation sickness crisis, and leukocyte is early recovered.Exposure animal takes after Ganoderma can appetite stimulator, improves the mental status.20 grams of the oral Ganodermas of normal person, can reduce heart rate.Main Function has:
One, the low or imbalance of antitumor action autoimmune function, is the major reason why tumor can occur and expand.Ganoderma is that best immunologic function regulates and activator, and it can significantly improve the immunologic function of body, strengthens patient's self anti-cancer ability.Ganoderma can be by promoting the generation of interleukin II, by the phagocytic function of promotion mononuclear phagocyte, by promoting the especially leukocytic index level of hematopoietic potential of human body, and pass through the wherein inhibitory action of some effective ingredient to cancerous cell, become the preferred agents of antitumor, anti-cancer and assistant treating cancer.Ganoderma to human body almost without any toxic and side effects.The advantage of this avirulent immune activation agent, many tumor chemotherapeutic drugs and other immunopotentiating agent do not have exactly.Two, the hepatic injury that protecting liver and detoxication effect Ganoderma causes multiple physics and chemistry and biological factor has protective effect.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote the metabolism of liver to medicine, poisonous substance, for toxic hepatitis, has definite curative effect.Especially chronic hepatitis, Ganoderma can obviously be eliminated the symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and can effectively improve liver function, makes indices be tending towards normal.So Ganoderma can be used for treating chronic poisoning, all kinds of chronic hepatitis, liver cirrhosis, hepatic insufficiency.Three, effect zoopery and the clinical trial of cardiovascular system are all shown; Ganoderma is coronary artery dilator effectively; increase coronary flow; improve Myocardial Microcirculation; strengthen the supply of myocardium oxygen and energy; therefore, myocardial ischemia is had to protective effect, can be widely used in treatment and the prevention of coronary heart diseases and angina pectoris etc.To high fat of blood patient, Ganoderma can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, have and reduce Arterial Cholesterol content, vessel softening, prevent the further effect of damage.And can improve local microcirculation, stop platelet aggregation.These effects have good preventive and therapeutic effect for polytype apoplexy.Four, the contained polysaccharide of anti-aging effects Ganoderma, polypeptide etc. have obvious function of delaying senility.This effect is mainly based on following mechanism: 1, promote and adjustment immunologic function.For adult and old people, this promotion and adjustment be slow down aging obviously.For the children in growth and development stage, can promote the perfect of its immunologic function, strengthen resistance against diseases, guarantee that it grows up healthy and sound.2, regulate metabolic balance, promote the synthetic of nucleic acid and protein.Research shows, serum, liver and the nucleic acid of bone marrow and the biosynthesis of protein when Ganoderma can be urged therefore can be effectively disease-resistant anti-aging.Observation shows, takes Ganoderma with defying age, not only useful to old people, the personage of business age level is suitable for, because the process of growth promoter is namely moved towards old and feeble process.3, anti-radical action.(as superoxide dismutase, reduction SOD), is a reason of human senility for the antioxidant of the interior originality defence radical damage that organism produces or antioxidant enzyme material.Ganoderan has significant plan SOD active, can significantly remove the free radical that body produces, thereby stops the damage of radical pair body, has prevented the peroxidating of fat body, has protected cell, has delayed cell ageing.4, ganoderan can show chopsticks promotion cell nuclear dna synthesis capability, and can increase the division algebraically of cell, thereby has delayed the aging of body.Five, neurasthenia effect Ganoderma is just for neurasthenia and insomnia, therefore it plays good effect to maincenter.Extract energy exciting motion suppresses, mobility is reduced, make coordination exercise imbalance, present the sick effect in dose-dependent town, hexobarbital sleep interaction energy is curtailed sleep, central stimulants caffeine be can extend and spasm and dead time caused, these results show, Ganoderma is inhibition effect to maincenter.The motherland contained Ganoderma of medicine can " be calmed the nerves ", " increasing wisdom ", " not forgetting ".It is reported, Ganoderma preparation has significant curative effect to neurasthenia's insomnia, and total effective rate is up to 87.14%～100%.After general medication, within 10～15 days, occur obvious curative effects, be indicated as sleep improvement, appetite, body weight increase, and cardiopalmus, headache, dizziness alleviate or disappear, in high spirits, hypermnesia.Belong to QI and blood deficiency person's better efficacy.So Ganoderma has stronger regulating action for central nervous system, there is the effect of tranquillizing and allaying excitement, for the weak and insomniac of remarkable ability, be indispensable good merchantable brand, in state-promulgated pharmacopoeia, Ganoderma is exactly the medicine of effectively sleeping peacefully and allaying excitement.< < Sheng Nong's herbal classic > > classifies Ganoderma as top grade, and meaning Ganoderma " make light of one's life by commiting suicide and always do not prolong life for a long time for main deafness, sharp joint; protect god's benefit essence; hard muscles and bones, good color by clothes." " invigorating middle warmer increases wisdom not to be forgotten meaning Ganoderma lucidum (Leyss. Ex Fr.) Karst. for main knot in the heart, the beneficial motive, and food of a specified duration is made light of one's life by commiting suicide not old, prolongs life and becomes an immortal." in recent years; to the research of Ganoderma lucidum seu Japonicum as emerged rapidly in large numbersBamboo shoots after a spring rain; clinical report is a lot of; be summed up following several respects: (1) controls chronic bronchitis: take Ganoderma tablet, days 3 times, each 1 (content is equivalent to 0.5 gram of crude drug); or with Ganoderma tincture (20% concentration); day 3 times, each 10 milliliters (every feed ration is equivalent to 6 grams of crude drugs), general 15～30 days start to take effect.(2) control bronchial asthma: 1～2 milliliter of pediatric patient intramuscular injection every day (every milliliter containing 0.5～1 gram of crude drug), inject about 1 month continuously.(3) control leukopenia: once treat leukopenia 52 examples that cause because of various factorss such as chemistry, physics, medicine and chronic diseases, effective percentage is 84.6% in the recent period, and total white blood cells is on average increased to 1028/ cubic millimeter.It within 10～20 days, is a course for the treatment of.(4) treatment coronary heart disease: to angina pectoris, pareordia feeling of distension and oppression, or the remission rate of sense of compression is about 72%, the improvement rate of the symptoms such as cardiopalmus, tachypnea is about to 65%, patient's period in a medicine reflections more than half: appetite, sleep, spirit take a turn for the better, reducing blood triglyceride has good therapeutic effect.Clinical trial all shows, Ganoderma is coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; myocardial ischemia is had to protective effect, can be widely used in treatment and the prevention of coronary heart diseases and angina pectoris etc.To high fat of blood patient, Ganoderma can obviously reduce cholesterolemia, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, have and reduce Arterial Cholesterol content, vessel softening, prevent the further effect of damage.And can improve local microcirculation, stop platelet aggregation.These effects have good preventive and therapeutic effect for polytype apoplexy.(5) treatment arrhythmia: in the process by Ganoderma treatment coronary heart disease, find when coronary heart disease is improved, the arrhythmia of following also, along with taking a turn for the better and disappearing, so adopt Ganoderma Ludicum Injection to treat various arrhythmia, obtains certain effect.(6) control acute viral hepatitis, better than traditional " hepatoprotective " curative effect of medication.In addition, be also used for the treatment of atrophic gastritis, malignant tumor etc.(7) neurasthenia.The contained Ganoderma of motherland's medical science can " be calmed the nerves ", " increasing wisdom ", " not forgetting ".It is reported, Ganoderma preparation has and is showing curative effect neurasthenia's insomnia, and total effective rate is up to 87.14%～100%.After general medication, within 10～15 days, occur obvious curative effects, be indicated as sleep improvement, appetite, body weight increase, and cardiopalmus, headache, dizziness alleviate or disappear, in high spirits, hypermnesia.Belong to QI and blood deficiency person's better efficacy.So Ganoderma has stronger regulating action for central nervous system, there is the effect of tranquillizing and allaying excitement, for neurasthenia and insomniac, be indispensable good merchantable brand, in state-promulgated pharmacopoeia, Ganoderma is exactly the medicine of effectively sleeping peacefully and allaying excitement.(8) treatment diabetes: the principle of Ganoderma blood sugar lowering is owing to promoting tissue to sugared utilization.After taking Ganoderma, disengaging of insulin inhibition fatty acid can be replaced, the symptoms such as blood glucose, glucose in urine can be improved.Blood glucose is down to 116 by 173, and cholesterol is down to 179, β-albumen by 233 and is down to 465 by 580.Water soluble polysaccharide in Ganoderma, can alleviate the occurring degree of non-insulin-dependent diabetes mellitus.The ganoderma health-care food that Japan Numata Kenji produces, has been widely used treatment diabetics.(9) anti-allergic effects: cause immunologic function hyperfunction when body is subject to certain antigen invasion and attack, while producing various allergy or autoimmune pathology infringement, Ganoderma can suppress hyperfunction immune level, keeps the stable of body self.Experimental results show that: the release of Ganoderma anaphylaxis medium capable of blocking, prevent anaphylactoid generation, therefore, for the more difficult allergy of current treatment or autoimmune disease.As: allergic asthma, lupus erythematosus, hyperthyroidism, allergic rhinitis, multiple refractory skin etc. all can play good effect, and can partly resist the toxic and side effects that some Disease occurs because of life-time service hormone.(10) treatment rheumatic and rheumatoid: Ganoderma has in rheumatism and rheumatoid clinical practice must curative effect, Ganoderma is to playing a role clearly in the adjusting of autoimmune and physiological function, complicated according to the theory of Chinese medical science rheumatoid arthritis cause of disease, belong to Chinese medical ' arthralgia syndrome ' category.Numbness is that obstructed meaning is closed in resistance, and the heresy that wind and cold is damp and hot, attacks human body in an opponent's defence, causes QI-blood circulation not smooth, and meridian stasis is stagnant; The generation of numbness disease also has substantial connection with the prosperity and decline of body constitution and climatic condition, living environment in addition., all once there was research the aspects such as difference of our Endocrine, metabolism, nutrition, geography, occupation, psychology and society environment with the relation of rheumatoid arthrosis morbidity.Antibacterial and viral infection and heredity, because of rope, may also have certain relation with morbidity.Generally acknowledge that at present rheumatoid arthritis is a kind of autoimmune disease.Wall breaking technology Ganoderma powder is taken and 2 ~ 3 courses for the treatment of rheumatic and rheumatoid is had to obvious improvement in clinical patients, and obvious effective rate is in 78% left and right.As can be seen here, the disease of Ganoderma lucidum seu Japonicum treatment, major part is the illness of senile, intractable, degenerative.
Ganoderma spore brown, avette, one end is truncate, (8.5～ll.2) um * (5. 2-6. 9) um, tool double wall.Brown internal layer at each spore produces many needle-like kicks, stretches into dearly the transparent outer layer of conidial cell wall, and outer sporoderm is smooth.Very tough and tensile, the general chemistry of two layers of walls of Ganoderma spore parcel, physical method is difficult to be broken, therefore limited the research to its chemical composition, bioactive ingredients.Set up effective wall-breaking method, can promote the research to the extraction of its bioactive ingredients and medical value.
The chemical composition of Ganoderma spore can be divided into following a few class: protein and amino acids, glycopeptide class, vitamins, carotene, sterols, triterpenes, alkaloids, fatty acid, lactone and inorganic ions etc.Ganoderma spore gives protein content and reaches 18%, and wherein the content of the body essential amino acids such as isoleucine, leucine lysine, valine, methionine, phenylalanine is very abundant, all from reaching 10 g/kg.Vitamins is mainly vitamin E (VE), and in every 100 g spores, VE content surpasses 60mg, also contains in addition a small amount of vitamin C.In Ganoderma spore, be rich in polysaccharide and oligosaccharide, wherein the content of disaccharide, trisaccharide, tetrose is respectively 1. 94,1.67 and 2.5 mg/g.Steroid has Ergota steroid-7,22-ethylene-3 β alcohol (ergosta-7,22-diene-3-ol) and cupreol.From the acidic extraction thing of Ganoderma lucidum (Leyss. Ex Fr.) Karst. spore powder, also separation has obtained some triterpenoid compound, and they are Ganosporeric acid A, B, C, E (ganosporeic acid A, B, C, E) and ganodenn anon-Trol.And constantly in Ganoderma spore, find new triterpene substance, these materials have good biological activity.Fatty acid in Ganoderma sterilization has lignoceric acid, stearic acid, Palmic acid, behenic acid etc.Its lactone generic pentacyclic triterpene lactone, has ganosporelactione A and B.Alkaloids has amine salt in choline, betanin and sulfur histidine methyl.Inorganic elements has calcium, phosphorus, ferrum, magnesium, sodium, zinc, germanium selenium etc., and wherein organic germanium and the mankind's key health and the control of disease have substantial connection.
The wall breaking technology of Ganoderma spore is the determiner of its drug effect quality, and in prior art, the breaking cellular wall that can differentiate spore by optical microscope whether.The conidial cell wall of breaking cellular wall is smooth not complete, and after broken wall treatment, conidial cell wall is imperfect, and content is irregular bulk.External multipurpose high-pressure air-flow method breaking cellular wall, its equipment one-time investment is large and fragile.The domestic people of having adopts enzymatic shell-broken. and first, with using combinative enzyme hydrolysis 4 days after alcohol-pickled 3 days, sporoderm-broken rate reaches 52% again., for the valuable ingredients of traditional Chinese medicine like this, or most effective ingredient has been wasted, and therefore, needs a kind of birth of wall breaking technology of better effects if.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defect, and the broken wall treatment agent of the Ganoderma spore that sporoderm-broken rate is high is provided.
Object of the present invention is carried out specific implementation by the following technical programs:
A kind of broken wall treatment agent of Ganoderma spore, its component by weight, its component by weight, 100 parts of ethanol, calcium oxalate 15-20 part, acetylcholine esterase 9-13 part, glycogen phosphorylase 6-10 part, citric acid 5-10 part, VE2-5 part, HEDP 0.1-0.5 part, zinc sulfate 0.01-0.5 part.
As preferred version, the broken wall treatment agent of above-mentioned Ganoderma spore, its component by weight, 100 parts of ethanol, 15 parts of calcium oxalates, 12 parts of acetylcholine esterase, 7.5 parts of glycogen phosphorylases, 6 parts of citric acids, 3 parts of VE, 0.3 part of HEDP, 0.05 part, zinc sulfate.
The broken wall treatment agent of above-mentioned Ganoderma spore only need to be soaked Ganoderma spore wherein 1-3 days before at mechanical breaking-wall method (generally adopting supersonic wave wall breaking) at 30-40 ℃.
Beneficial effect of the present invention:
The broken wall treatment agent of Ganoderma spore provided by the present invention, according to the structure organization of Ganoderma spore, carrying out targetedly cell wall tissue dissociates, can make the cell wall of Ganoderma spore just can thoroughly disintegrate under the condition of general mechanical breaking-wall method, the part that effectively has in cell is discharged completely fast, and sporoderm-broken rate can reach more than 90%.And adding of VE, calcium oxalate, can also improve the drug effect of Ganoderma spore.
The specific embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
embodiment 1:
A kind of broken wall treatment agent of Ganoderma spore, its component by weight, its component by weight, 100 parts of ethanol, 15 parts of calcium oxalates, 12 parts of acetylcholine esterase, 7.5 parts of glycogen phosphorylases, 6 parts of citric acids, 3 parts of VE, 0.3 part of HEDP, 0.05 part, zinc sulfate.
embodiment 2:
A kind of broken wall treatment agent of Ganoderma spore, its component by weight, its component by weight, 100 parts of ethanol, 15 parts of calcium oxalates, 13 parts of acetylcholine esterase, 6 parts of glycogen phosphorylases, 10 parts of citric acids, 2 parts of VE, 0.5 part of HEDP, 0.01 part, zinc sulfate.
embodiment 3:
A kind of broken wall treatment agent of Ganoderma spore, its component by weight, its component by weight, 100 parts of ethanol, 20 parts of calcium oxalates, 9 parts of acetylcholine esterase, 10 parts of glycogen phosphorylases, 5 parts of citric acids, 5 parts of VE, 0.1 part of HEDP, 0.5 part, zinc sulfate.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (2)
1. the broken wall treatment agent of a Ganoderma spore, it is characterized in that: its component by weight, 100 parts of ethanol, calcium oxalate 15-20 part, acetylcholine esterase 9-13 part, glycogen phosphorylase 6-10 part, citric acid 5-10 part, VE2-5 part, HEDP 0.1-0.5 part, zinc sulfate 0.01-0.5 part.
2. the broken wall treatment agent of Ganoderma spore according to claim 1, it is characterized in that: its component by weight, 100 parts of ethanol, 15 parts of calcium oxalates, 12 parts of acetylcholine esterase, 7.5 parts of glycogen phosphorylases, 6 parts of citric acids, 3 parts of VE, 0.3 part of HEDP, 0.05 part, zinc sulfate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430523A (en) * | 2014-11-17 | 2015-03-25 | 柳州市天姿园艺有限公司 | Germination accelerating treatment agent of Brazilian cherry seeds |
| CN104488967A (en) * | 2014-11-17 | 2015-04-08 | 柳州市天姿园艺有限公司 | Germination accelerating processing agent having antibiosis function for Brazilian cherry seeds |
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| CN101113429A (en) * | 2007-06-25 | 2008-01-30 | 沈阳市航达科技有限责任公司 | Plant spore extrusion wall breaking method |
| CN101380340A (en) * | 2008-10-14 | 2009-03-11 | 广东南台药业有限公司 | Wall-broken glossy ganoderma spore powder antioxidation method |
| CN101991615A (en) * | 2009-08-14 | 2011-03-30 | 安徽同泰药业有限公司 | Method for producing ganoderma spore by breaking wall |
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2013
- 2013-12-13 CN CN201310674071.5A patent/CN103705547A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101113429A (en) * | 2007-06-25 | 2008-01-30 | 沈阳市航达科技有限责任公司 | Plant spore extrusion wall breaking method |
| CN101380340A (en) * | 2008-10-14 | 2009-03-11 | 广东南台药业有限公司 | Wall-broken glossy ganoderma spore powder antioxidation method |
| CN101991615A (en) * | 2009-08-14 | 2011-03-30 | 安徽同泰药业有限公司 | Method for producing ganoderma spore by breaking wall |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430523A (en) * | 2014-11-17 | 2015-03-25 | 柳州市天姿园艺有限公司 | Germination accelerating treatment agent of Brazilian cherry seeds |
| CN104488967A (en) * | 2014-11-17 | 2015-04-08 | 柳州市天姿园艺有限公司 | Germination accelerating processing agent having antibiosis function for Brazilian cherry seeds |
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Application publication date: 20140409 |