CN103710264B - A kind of broken wall supplementary additive of Ganoderma spore - Google Patents
A kind of broken wall supplementary additive of Ganoderma spore Download PDFInfo
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- CN103710264B CN103710264B CN201310674828.0A CN201310674828A CN103710264B CN 103710264 B CN103710264 B CN 103710264B CN 201310674828 A CN201310674828 A CN 201310674828A CN 103710264 B CN103710264 B CN 103710264B
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Abstract
The invention discloses a kind of broken wall supplementary additive of Ganoderma spore, its component by weight, diethylamine 100 parts, citric acid 45-48 part, oxalic acid 20-24 part, vitamin-E? 10-13 part, yeast nucleic acid 1-5 part, amylase 0.5-2 part.The broken wall supplementary additive of Ganoderma spore provided by the present invention, can make the cell walls of Ganoderma spore form vesicular structure fast when ultrasonication, thus the effective constituent in cell is discharged fast, and sporoderm-broken rate can reach 98%.
Description
Technical field
The present invention relates to a kind of plant tissue decomposition agent.
Background technology
Glossy ganoderma, property is sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Cure mainly consumptive disease, cough, asthma, insomnia, maldigestion, malignant tumour etc.Animal pharmacology shows experiment: glossy ganoderma has restraining effect to neural system, and the recycle system has step-down and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, protects liver in addition, improves immunologic function, antibacterially waits effect.According to animal experiment, there are calmness, analgesic activity to small white mouse.Can improve that small white mouse is cold-resistant, hypoxia-bearing capability, and postpone its death time.Be that master is equipped with the Chinese medicines such as the bighead atractylodes rhizome, pseudo-ginseng, Ligusticum wallichii with glossy ganoderma, then can significantly improve the survival rate of animal, and animal can be helped to tide over radiation syndrome crisis, and white corpuscle is comparatively early recovered.Can improve a poor appetite after exposure animal takes glossy ganoderma, improve the mental status.The oral glossy ganoderma of normal people 20 grams, can reduce heart rate.Main Function has:
Low or the imbalance of antitumor action autoimmune function is why tumour can occur and the major reason expanded.Glossy ganoderma is best Immunity regulation and activator, and it can significantly improve the immunologic function of body, strengthens the anti-cancer ability of patient self.Glossy ganoderma can by promoting the generation of interleukin II, by promoting the phagocytic function of mononuclear macrophage, by promoting the especially leukocytic index level of hematopoietic potential of human body, and by wherein some effective constituent to the restraining effect of cancer cells, become antitumor, the preferred agents of anti-cancer and assistant treating cancer.Glossy ganoderma to human body almost without any toxic side effect.The advantage of this avirulent immune activation agent, many tumor chemotherapeutic drugs and other immunopotentiating agent do not have exactly.Two, protecting liver and detoxication effect glossy ganoderma has provide protection to the liver injury that multiple physics and chemistry and biotic factor cause.No matter before liver damage occurs or after generation, take glossy ganoderma and all can protect liver, alleviate liver injury.Glossy ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Especially chronic hepatitis, glossy ganoderma obviously can eliminate the symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and effectively can improve liver function, makes indices be tending towards normal.So glossy ganoderma can be used for treating chronic poisoning, all kinds of chronic hepatitis, liver cirrhosis, hepatic insufficiency.Three, the effect experimentation on animals of cardiovascular systems and clinical trial are all shown; glossy ganoderma can coronary artery dilator effectively; increase coronary flow; improve Myocardial Microcirculation; strengthen the supply of myocardium oxygen and energy; therefore, to myocardial ischemia, there is provide protection, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.To high fat of blood patient, glossy ganoderma can obviously reduce blood cholesterol, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, then there are reduction Arterial Cholesterol content, vessel softening, prevent the effect of damage further.And can local microcirculation be improved, stop platelet aggregation.These effects have good preventive and therapeutic effect for polytype apoplexy.Four, the polysaccharide contained by anti-aging effects glossy ganoderma, polypeptide etc. have obvious function of delaying senility.This effect is mainly based on following mechanism: 1, promote and adjustment immunologic function.For grownup and the elderly, this promotion and adjustment can obviously delay senility.For the children being in growth and development stage, then can promote the perfect of its immunologic function, strengthen resistance against diseases, guarantee that it is grown up healthy and sound.2, regulate metabolic balance, promote the synthesis of nucleic acid and protein.Research shows, the nucleic acid of serum, liver and marrow and the biosynthesizing of protein when glossy ganoderma can be urged, therefore can be effectively disease-resistant anti-aging.Observation shows, takes glossy ganoderma with anti-ageing, not only useful to the elderly, all applicable to the personage of business age level, because the process of growing, namely moves towards old and feeble process.3, anti-radical action.The interior originality defence antioxidant of radical damage that organism produces or the reduction of antioxidant enzyme material (as superoxide-dismutase, SOD) are reasons of human senility.Ganoderan has significant plan SOD active, significantly can remove the free radical that body produces, thus stop the damage of radical pair body, prevent the peroxidation of fat body, protect cell, delayed cell aging.4, ganoderan can show chopsticks promotion cell nuclear dna synthesis capability, and can increase the division algebraically of cell, thus has delayed the aging of body.Five, neurasthenia effect glossy ganoderma is just for neurasthenia and insomnia, therefore it plays good effect to maincenter.Extract energy exciting motion suppresses, mobility is reduced, coordinated movement is lacked of proper care, presents the sick effect in dose-dependent town, hexobarbital sleep interaction energy is curtailed sleep, the time that central nervous system stimulants caffeine causes spasm and death can be extended, these results show, glossy ganoderma is inhibition effect to maincenter.The motherland contained glossy ganoderma of medicine can " be calmed the nerves ", " increasing wisdom ", " not forgetting ".It is reported, Ganoderma preparation has significant curative effect to neurasthenia insomnia, and total effective rate is up to 87.14% ~ 100%.Within after general medication 10 ~ 15 days, namely occur obvious curative effects, be indicated as sleep improvement, appetite, body weight increase, and palpitaition, headache, dizziness alleviate or disappear, in high spirits, hypermnesia.Belong to qi-blood deficiency person's better efficacy.So glossy ganoderma has stronger regulating effect for central nervous system, having effect of tranquilizing and allaying excitement, is indispensable good merchantable brand for the weak and insomniac of remarkable ability, and in state-promulgated pharmacopoeia, glossy ganoderma is exactly effective sleeping medicine of allaying excitement.Shennong's Herbal is classified as glossy ganoderma top grade, and " protect god's benefit essence, hard muscles and bones, good color, clothes are made light of one's life by commiting suicide and always do not prolonged life for a long time for main deafness, sharp joint to call purple sesame." " master ties in the heart, the beneficial motive, and bowl spares increases wisdom and do not forget, and food is made light of one's life by commiting suicide old for a long time, prolongs life and becomes an immortal to call red sesame." in recent years; to the research of Ganoderma lucidum seu Japonicum as emerged rapidly in large numbersBamboo shoots after a spring rain; clinical report is a lot of; be summed up following several respects: (1) controls chronic bronchitis: take Investigation of Lingzhi Tablets, day 3 times, each 1 (content is equivalent to crude drug 0.5 gram); or with glossy ganoderma tincture (20% concentration); day 3 times, each 10 milliliters (every feed ration is equivalent to crude drug 6 grams), general 15 ~ 30 days start to take effect.(2) bronchial asthma is controlled: pediatric patient intramuscular injection every day 1 ~ 2 milliliter (every milliliter containing 0.5 ~ 1 gram of crude drug), injection about 1 month continuously.(3) leukopenia is controlled: once treat leukopenia 52 example because the various factorss such as chemistry, physics, medicine and chronic disease cause, efficient is in the recent period 84.6%, and total white blood cells is on average increased to 1028/ cubic millimeter.It within 10 ~ 20 days, is a course for the treatment of.(4) coronary heart disease is treated: to stenocardia, that pareordia is swollen is vexed, or the remission rate of sense of compression is about 72%, be about 65% to the improvement rate of the symptom such as palpitaition, shortness of breath, reflect during patient consumes more than half: appetite, sleep, spirit take a turn for the better, reducing blood triglyceride has good therapeutic effect.Clinical trial all shows, glossy ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is provide protection, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.To high fat of blood patient, glossy ganoderma can obviously reduce blood cholesterol, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, then there are reduction Arterial Cholesterol content, vessel softening, prevent the effect of damage further.And can local microcirculation be improved, stop platelet aggregation.These effects have good preventive and therapeutic effect for polytype apoplexy.(5) treat irregular pulse: in the process by glossy ganoderma treatment coronary heart disease, find while coronary heart disease is improved, adjoint irregular pulse, also along with improvement and disappearance, so adopt Ganoderma Ludicum Injection to treat various irregular pulse, obtains certain effect.(6) acute viral hepatitis is controlled, better than traditional " protecting liver " curative effect of medication.In addition, also atrophic gastritis is used for the treatment of, malignant tumour etc.(7) neurasthenia.The contained glossy ganoderma of motherland's medical science can " be calmed the nerves ", " increasing wisdom ", " not forgetting ".It is reported, Ganoderma preparation is had a sleepless night to have to neurasthenia and is shown curative effect, and total effective rate is up to 87.14% ~ 100%.Within after general medication 10 ~ 15 days, namely occur obvious curative effects, be indicated as sleep improvement, appetite, body weight increase, and palpitaition, headache, dizziness alleviate or disappear, in high spirits, hypermnesia.Belong to qi-blood deficiency person's better efficacy.So glossy ganoderma has stronger regulating effect for central nervous system, having effect of tranquilizing and allaying excitement, is indispensable good merchantable brand for neurasthenia and insomniac, and in state-promulgated pharmacopoeia, glossy ganoderma is exactly effective sleeping medicine of allaying excitement.(8) diabetes are treated: the hypoglycemic principle of glossy ganoderma is owing to promoting the utilization of tissue to sugar.Regular Insulin can be replaced after taking glossy ganoderma and suppress disengaging of lipid acid, the symptom such as blood sugar, glucose in urine can be improved.Blood sugar is down to 116 by 173, and cholesterol is down to 179, β-albumen by 233 and is down to 465 by 580.Water-soluble polysaccharide in glossy ganoderma, can alleviate the occurring degree of non insulin dependent diabetes.The ganoderma health-care food that Japan Numata Kenji produces, has widely used treatment diabetic subject.(9) anti-allergic effects: when body causes immunologic function hyperfunction by certain antigen challenge, when producing various transformation reactions or autoimmune pathology infringement, glossy ganoderma can suppress hyperfunction immune level, keeps the stable of body self.Experiment proves: the release of glossy ganoderma anaphylaxis medium capable of blocking, prevents anaphylactoid generation, therefore, for treating more difficult allergy or autoimmune disorder at present.As: allergic asthma, lupus erythematosus, hyperthyroidism, allergic rhinitis, multiple refractory skin etc. all can play good effect, and can the toxic side effect that occurs because of life-time service hormone of some Disease of partial agonistic.(10) rheumatic and rheumatoid is treated: glossy ganoderma has in rheumatism and similar rheumatism clinical application must curative effect, glossy ganoderma is to playing a role clearly in the adjustment of autoimmunity and physiological function, complicated according to the theory of traditional Chinese medical science rheumatoid arthritis cause of disease, belong to Chinese medical ' arthralgia syndrome ' category.Numbness is that resistance closes obstructed meaning, the heresy that chill is damp and hot, attacks human body in an opponent's defence, and cause QI-blood circulation not smooth, meridian stasis is stagnant; The generation of numbness disease also has substantial connection with the prosperity and decline of physique and climatic condition, living environment in addition.The aspects such as the difference of our Endocrine, metabolism, nutrition, geography, occupation, psychology and society environment, the relation of falling ill with rheumatoid arthrosis all once had research.Bacterium and virus infection and heredity, because of rope, may also have certain relation with morbidity.Generally acknowledge that rheumatoid arthritis is a kind of autoimmune disorder at present.Wall breaking technology Ganoderma powder is taken in clinical patients has obvious improvement to rheumatic and rheumatoid 2 ~ 3 courses for the treatment of, and obvious effective rate is about 78%.As can be seen here, the disease of Ganoderma lucidum seu Japonicum treatment, major part is senile, intractable, degenerative illness.
Ganoderma spore brown, avette, one end is truncate, (8.5 ~ ll.2) um × (5. 2-6. 9) um, tool double wall.Produce many needle-like pimples at the brown internal layer of each spore, stretch into the transparent outer layer of conidial cell wall dearly, outer sporoderm is smooth.The two layers of walls of Ganoderma spore parcel is very tough and tensile, general chemistry, and physical method is difficult to be broken, therefore limits the research to its chemical composition, bioactive ingredients.Set up effective wall-breaking method, the research of extraction to its bioactive ingredients and pharmaceutical use can be promoted.
The chemical composition of Ganoderma spore can be divided into following a few class: protein and amino acids, glycopeptide class, vitamins, carotene, sterols, triterpenes, alkaloids, fatty acid, lactone and mineral ion etc.Glossy ganoderma spore gives protein content and reaches 18%, and wherein the content of the body indispensable amino acid such as Isoleucine, leucine Methionin, α-amino-isovaleric acid, methionine(Met), phenylalanine is very abundant, all from reaching 10 g/kg.Vitamins is vitamin-E (VE) mainly, and in every 100 g spores, VE content, more than 60mg, also contains a small amount of vitamins C in addition.Be rich in polysaccharide and oligosaccharides in Ganoderma spore, wherein the content of disaccharides, trisaccharide, tetrose is 1. 94,1.67 and 2.5 mg/g respectively.Steroid has ergot steroid-7,22-ethene-3 β alcohol (ergosta-7,22-diene-3-ol) and β-sitosterol.Also be separated from the acidic extraction thing of red Ganoderma lucidum spore powder and obtain some triterpene compounds, they are Ganosporeric acid A, B, C, E (ganosporeic acid A, B, C, E) and ganodenn anon-Trol.And constantly find new triterpene substance in Ganoderma spore, these materials have good biological activity.Fatty acid in the exhausted son of glossy ganoderma has Lignoceric acid, stearic acid, palmitinic acid, docosoic acid etc.Its lactone generic pentacyclic triterpene lactones, has ganosporelactione A and B.Alkaloids has amine salt in choline, trimethyl-glycine and sulphur Histidine methyl.Inorganic elements has calcium, phosphorus, iron, magnesium, sodium, zinc, germanium selenium etc., and wherein the key health of organic germanium and the mankind and the control of disease have substantial connection.
The wall breaking technology of Ganoderma spore is the determinative of its drug effect quality, in prior art, whether can differentiate the broken wall of spore by opticmicroscope.The conidial cell wall of non-broken wall is smooth complete, and after broken wall treatment, conidial cell wall is imperfect, and content is irregular bulk.External multipurpose high-pressure air-flow method broken wall, its equipment one-time investment is large and fragile.The method time of this broken wall is long, broken wall damage is large, and sporoderm-broken rate is low.
Summary of the invention
The technical problem to be solved in the present invention overcomes existing defect, provides the broken wall supplementary additive of the high Ganoderma spore of sporoderm-broken rate.
Object of the present invention carrys out specific implementation by the following technical programs:
A broken wall supplementary additive for Ganoderma spore, its component by weight, diethylamine 100 parts, citric acid 45-48 part, oxalic acid 20-24 part, vitamin-E 10-13 part, yeast nucleic acid 1-5 part, amylase 0.5-2 part.
Preferably, the broken wall supplementary additive of above-mentioned Ganoderma spore, its component by weight, diethylamine 100 parts, citric acid 46.5 parts, oxalic acid 21 parts, vitamin-E 12.5 parts, yeast nucleic acid 4.5 parts, amylase 0.5 part.
The broken wall supplementary additive of above-mentioned Ganoderma spore, is generally applied in supersonic wave wall breaking process, will the material of broken wall be needed to be immersed in broken wall supplementary additive, and ultrasonic vibration limit, limit is stirred.
Beneficial effect of the present invention:
The broken wall supplementary additive of Ganoderma spore provided by the present invention, can make the cell walls of Ganoderma spore form vesicular structure fast when ultrasonication, thus the effective constituent in cell is discharged fast, and sporoderm-broken rate can reach 98%.
Embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein is only for instruction and explanation of the present invention, is not intended to limit the present invention.
embodiment 1:
A broken wall supplementary additive for Ganoderma spore, its component by weight, diethylamine 100 parts, citric acid 46.5 parts, oxalic acid 21 parts, vitamin-E 12.5 parts, yeast nucleic acid 4.5 parts, amylase 0.5 part.
embodiment 2:
A broken wall supplementary additive for Ganoderma spore, its component by weight, diethylamine 100 parts, citric acid 45 parts, oxalic acid 24 parts, vitamin-E 10 parts, yeast nucleic acid 5 parts, amylase 0.5 part.
embodiment 3:
A broken wall supplementary additive for Ganoderma spore, its component by weight, diethylamine 100 parts, citric acid 48 parts, oxalic acid 20 parts, vitamin-E 13 parts, yeast nucleic acid 1 part, amylase 2 part.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. a broken wall supplementary additive for Ganoderma spore, is characterized in that: its component by weight, diethylamine 100 parts, citric acid 45-48 part, oxalic acid 20-24 part, vitamin-E 10-13 part, yeast nucleic acid 1-5 part, amylase 0.5-2 part.
2. the broken wall supplementary additive of Ganoderma spore according to claim 1, is characterized in that: its component by weight, diethylamine 100 parts, citric acid 46.5 parts, oxalic acid 21 parts, vitamin-E 12.5 parts, yeast nucleic acid 4.5 parts, amylase 0.5 part.
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| CN104073344B (en) * | 2014-07-16 | 2016-08-24 | 江苏斯威森生物医药工程研究中心有限公司 | A kind of extracting method of Ganoderma spore oil |
| CN108148677B (en) * | 2017-12-28 | 2021-06-08 | 晨光生物科技集团股份有限公司 | Continuous extraction method of pepper oleoresin |
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