CN101433329B - Nutritive composition with health-care function - Google Patents
Nutritive composition with health-care function Download PDFInfo
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- CN101433329B CN101433329B CN2008102435233A CN200810243523A CN101433329B CN 101433329 B CN101433329 B CN 101433329B CN 2008102435233 A CN2008102435233 A CN 2008102435233A CN 200810243523 A CN200810243523 A CN 200810243523A CN 101433329 B CN101433329 B CN 101433329B
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Abstract
The invention relates to a nutritive composition which consists of resveratrol and yeast glucan and has the function of health protection. The nutritive composition overcomes the defects of poor treatment effect and toxic and side effects by adopting Western medicines for hyperglycemic and hypolipemic treatment in the prior art. The resveratrol is an important plant antitoxin and has the functions of antioxidation, prevention and treatment of cardiovascular diseases, prevention of cancer, antivirus and immunoloregulation; the yeast glucan has the functions of clearing intestine, regulating the blood sugar, reducing cholesterin, improving the immunity and so on; and when the two types of immunomodulator, namely the resveratrol and the yeast glucan, are combined and applied, Cdc42 expression is obviously improved, and the resveratrol and the yeast glucan have stronger synergism. For example, the resveratrol and the yeast glucan express obvious synergistic effect in monocytes and neutrophilic granulocytes, and three cytokines (IL-1, IL-6 and TNF-alpha) are obviously lifted; and the nutritive composition influences the restoring activity of spleen cells and fluorouracil-induced leucocytopenia.
Description
Technical field
The present invention relates to a kind of alimentation composition, particularly a kind of alimentation composition of forming by resveratrol and yeast dextran with health care with health care.
Background technology
Along with the develop rapidly of global economy, existent environment of people is faced with unprecedented crisis and challenge.Intense market competition, the increase of society and operating pressure, bad life and dietary habit; The environmental pollution that the industry develop rapidly is brought, the physical and mental health of wrecking people is destroyed and the weakening body's immunity; Make that the defence capability of human body self is weakened greatly, cause tumor patient every year, add the tumor patient of survival accumulation with 3.5% speed increase; Be used for the tumor treatment expense every year up to more than 3000 hundred million; Enhancing immunity is the fundamental means that the protection cell does not receive extraneous cause of disease infringement, thereby the body of avoiding virus to get into us thus causes the generation of excessive free radicals, simultaneously; The pernicious variation of cell more can monitored and prevent to the immune system that has strengthened, and prevents fundamentally that cell from " getting rusty ".
Hyperglycemia, hyperlipemia have become a kind of commonly encountered diseases of middle-aged and elderly people, and along with growth in the living standard, sickness rate has obvious ascendant trend.Hyperglycemia, hyperlipidemia, fatty liver are the common diseases in the modern life, and the trend of rejuvenation is arranged.Hyperlipidemia can cause multiple cardiovascular disease, and fatty liver then can cause the infringement of liver function, develops into fatty liver hepatopathy and hepatic fibrosis, even causes fatty cirrhosis or its relevant disease.Hyperglycemia is bigger to body harm, mainly shows as to cause blood vessel, neural complication, and the β cell function is depleted, electrolyte disturbance, and serious dehydration, osmotic pressure increases, malaise, visual deterioration causes functional disorders of brain, claims hyperosmolar coma clinically.Blood glucose, blood lipid metabolism imbalance, endocrine regulation, alcoholic liver injury, drinking and eating irregularly etc. are the main causes that causes hyperlipidemia, fatty liver.
Before the present invention, adopt western medicine hyperglycemia, hyperlipemia clinically, yet take the many untoward reaction of meeting generation in the Western medicine for a long time, treat weak curative effect, and toxic side effect as simple with Western medicine blood sugar lowering, blood fat reducing.Nearly all Western medicine all has Liver and kidney toxicity, and most of Western medicine have gastrointestinal reaction; The good more toxic and side effects of effect is big more; The clothes Western medicine decreases liver for a long time, is impairment of the kidney, and the stimulating gastrointestinal road brings side effect to let the patient suffer untold misery.
Western medicine is startling to the infringement of human body, and medical research shows that human body when taking Western medicine blood sugar lowering, blood fat reducing treatment in a large number, has also shortened the human life-span greatly! With a patient who takes Western medicine for a long time is example, and one day three times, once two, the quantity that each year takes is 2190, and the weight of Western medicine approximates 65.7 jin, and it is half the to be equivalent to the human body normal type.Blood sugar lowering, blood fat reducing Western medicine, whenever taking once will be to the organ injury 5%-15% of health, especially huge to the infringement of kidney, liver, heart.The person more than 2 years that takes medicine, its immunity of human body itself sharply reduces, and immunologic function degression is obviously or basic forfeiture.And take Western medicine for a long time, and can produce dependency to Western medicine, cause dose to eat bigger and bigger, kind is more and more, causes some patient to take medicine all the life, stands the hardship of huge side effect murder by poisoning all the life.
Summary of the invention
The objective of the invention is to overcome the prior art defective, develop a kind of alimentation composition that is used for health care.
Technical scheme of the present invention is:
A kind of alimentation composition that is used for health care, its major technique are characterised in that by resveratrol, yeast dextran to be formed.
Its further technical scheme is:
Resveratrol, yeast dextran compatibility relationship are resveratrol 20～350mg, yeast dextran 50～1500mg.
Advantage of the present invention and effect are that yeast dextran cooperates with resveratrol; Adopt suitable compatible combination; Collaborative playing a role provides one can be comprehensive to have effects such as enhancing immunity, blood fat reducing, blood sugar lowering, antioxidation to a plurality of links a kind of, and effect is more obvious.
The present invention compares prior art and has following advantage: this prescription safely, have no side effect.
Composition in this prescription has following function:
1, resveratrol, chemical name are resvertrol, molecular formula C
14H
12O
3, molecular weight 228.25 results from grape leaf epidermis and the berry peel, is plant infects reaction to fungal disease result.It exists with two kinds of forms of free state (cis-, trans-) and glucosides combined state (cis-, trans-), and all has antioxidation usefulness, is a kind of important phytoalexin in the Fructus Vitis viniferae.Pharmacological action: the generation of anti-bacteria and anti-virus, antitumor, anti-hepatitis, inhibition platelet aggregation and thromboxane B2.It can stop the oxidation of low density lipoprotein, LDL, has potential cardiovascular disease, anti-cancer, antiviral and the immunoregulation effect prevented and treated, and its effect mainly shows as its anti-oxidation characteristics.Clinical practice: be used for the acute icteric infectious hepatitis, blood stasis amenorrhea, rheumatism type arthralgia, bones and muscles pain, sand Stranguria, stranguria with blood, tracheitis, damp-heat type gall stone; Be used for cholesterolemia and triglyceride is too high; Be used for antioxidation, slow down aging.Safety: discharge lactic acid dehydrogenase with leukocyte and detect the safety of resveratrol, find that its LD50 is per kilogram of body weight 1000mg as the index of cell injury.5 * 10-7 is lower than 7% to the release of the lactic acid dehydrogenase that the resveratrol of putting 10-3M causes.Make veratryl alcohol clear and have very high safety.
2, yeast dextran is from the cell wall of pure natural bakery yeast, to separate to make; Be rich in 1; 3 and 1, the 6-beta glucan, biomedical boundary generally believes that beta glucan has four big physiological actions such as bowel relieving, blood sugar regulation, cholesterol reducing, raising immunity; Beta glucan can improve the metaboilic level of fat, reduces the cholesterol in serum level.Can also improve of the impression of tip tissue, reduce requirement, promote glucose to recover normal, diabetes are had obvious suppression and preventive effect insulin to insulin.Safety testing: (standard dose is that human body is taken 100mg for one kilogram in the toxicologic research of chronic mice in 90 days; Continued to take 90 days); No mortality rate and sickness rate; Do not have the growth of promotion and weight gaining effect,, can accomplish responsive toxicity Journal of Sex Research smoothly at 2000mg/kg BW to clinical symptoms, ophthalmology, nerve, physiology, immunologic function and pathological findings moment-less influence.
Description of drawings
-------monomer and compositions are to the phagocytosis sketch map of synthetic HEMA microsphere for Fig. 1.
-------monomer and compositions are to the sketch map that influences of several cell membrane labelled molecule expression for Fig. 2.
-------monomer and compositions are to the sketch map that influences of 3 kinds of release of cytokines in the body for Fig. 3.
-------monomer and compositions are to influence (bone marrow) sketch map of the inductive leukopenia of fluorouracil for Fig. 4.
-------monomer and compositions are to influence (splenocyte) sketch map of the inductive leukopenia of fluorouracil for Fig. 5.
Fig. 6-------monomer and compositions be to the NF-κ B2 of ZR-75-1 cell, Cdc42 and Bcl-2 expression influence sketch map.
Annotate: Control matched group, Glucan glucosan, Resveratrol resveratrol, Combination compositions.
The specific embodiment
The present invention presses Chinese medical theory and modern medicine study; Adopt suitable compatible combination; Collaborative playing a role; Provide one can be comprehensive to have effects such as enhancing immunity, blood fat reducing, blood sugar lowering, antioxidation, with natural constituents and health product of being mixed with and uses thereof to a plurality of links a kind of.
Particularly:
The present invention is made up of resveratrol, yeast dextran.
Embodiment 1:
Get resveratrol 40mg, yeast dextran 1000mg, mix homogeneously; Can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 2:
Get resveratrol 60mg, yeast dextran 500mg, mix homogeneously; Can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 3:
Get resveratrol 150mg, yeast dextran 250mg, mix homogeneously; Can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 4:
Get resveratrol 300mg, yeast dextran 250mg, mix homogeneously; Can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 5:
Get resveratrol 20mg, yeast dextran 1500mg, mix homogeneously; Can be made into oral liquid, capsule, tablet, granule, powder.
Embodiment 6:
Get resveratrol 350mg, yeast dextran 50mg, mix homogeneously; Can be made into oral liquid, capsule, tablet, granule, powder.
Experiment proof: estimate glucosan and resveratrol composition possible synergism in immunoreation.
Method: we adopt poly hydroxy ethyl acrylate (HEMA) particle to estimate phagocytosis; Applying flow cytometry detects the expression of cell surface marker; Detect cytokine expression through ELISA; Observing fluorouracil induces the reparation of cell after the leukopenia and detects the influence for gene expression through RT-PCR.
The result shows that glucosan and resveratrol composition all can excite leukocytic phagocytosis, increases the expression of CD+ splenocyte surface molecular, the repair ability of spleen after the inductive leukopenia of raising experiment.Under the situation of all these, all observed their strong synergism.When detect these materials for breast cancer cell in NF-κ B2, find that only when Combined application glucosan and these two kinds of immunomodulators of resveratrol, the expression of Cdc42 just has tangible rise during the influencing of the expression of Cdc42 and Bcl-2.
Conclusion: these two kinds of natural immunity regulators have significant synergism in the challenge process.
We have confirmed the effect to macrophage of multiple glucosan and resveratrol.Yet, there is immunoregulatory characteristic in order to prove immune modulator composition, also must observe it to phagocytotic influence.We have detected glucosan and/or the resveratrol composition phagocytosis to synthetic HEMA microsphere, and are as shown in Figure 1.
Glucosan and resveratrol composition can both excite the endocytosis of synthetic microsphere.Yet combination preparation shows significant cooperative effect in mononuclear cell and neutrophilic granulocyte.Subsequently, we have observed the influence that glucosan and resveratrol composition are expressed for several cell membrane labelled molecule.After the intraperitoneal injection 24 hours, detect splenocyte surface molecular CD4 (T assists lymphocyte), CD8 (T inhibition lymphocyte), and the expression of CD19 (bone-marrow-derived lymphocyte).The result is as shown in Figure 2, has only the CD4+ lymphocyte to be influenced.Glucosan and resveratrol composition show the obvious synergistic effect again.Opposite, abdominal cavity (transudate) cell just receives slight influence.
We have compared the influence that single intraperitoneal injection glucosan and resveratrol composition discharge for 3 kinds of cytokines (IL-1, IL-6 and TNF-α) in the body.Inject and gather peripheral blood after 60 minutes and deposit in-80 ℃, the resting period is no more than a week.The dosage of injection and time point are to establish according to former experiment.The result is as shown in Figure 3, and the level of three kinds of cytokines significantly rises behind glucosan and the resveratrol composition joint injection.Simple resveratrol composition stimulates the release of IL-6 and IL-1, and glucosan does not then have this effect.
Similar with cyclophosphamide, press down the cancer drug 5-fluorouracil and significantly suppress immune system.We have studied the influence to the inductive leukopenia of fluorouracil of oral glucosan and resveratrol composition.The result shows that though glucosan increases the reparation of bone marrow greatly, the resveratrol application 1 just shows significant stimulation after 0 day.And the compositions Combined application of two kinds of materials, it is as shown in Figure 4 that glucosan and resveratrol demonstrate slight synergism.
But having found condition of different at spleen, though glucosan has shown the activity higher than resveratrol composition once more, also is just to show obviously high splenocyte repairing activity from the 4th day.Unite and use glucosan and resveratrol composition promptly to demonstrate intensive synergism since the 11st day, as shown in Figure 5.
Fig. 6 is RT-PCR figure (annotating: A matched group, B glucosan, C resveratrol, D compositions), and it shows that glucosan and/or resveratrol composition are to the NF-κ B2 of ZR-75-1 cell, the influence of Cdc42 and Bcl-2 expression.Glucosan and resveratrol effect have tangible rise to the expression of NF-κ B2 and Bcl-2, and the effect of resveratrol composition is compared with cellular control unit then has only slight enhancing.In addition, Combined application is similar with resveratrol for the effect of these expression of gene.Yet, have only when Combined application, the just obviously expression of rise Cdc42 simultaneously of two kinds of immunomodulators.
Particularly:
As everyone knows, panimmunity regulator, particularly glucosan can excite phagocytosis.Therefore, any the effectiveness of bioactive immunomodulator is arranged is very important for proof to estimate this basic immunoreation.We have observed the phagocytotic variation of PBL.Use synthetic HEMA microgranule, we find that glucosan and resveratrol all cause phagocytotic remarkable increase, and still, composite preparation demonstrates the obvious synergistic effect for mononuclear cell and neutrophilic granulocyte.The result shows, is that the injection of glucosan or resveratrol all has effect.These effects were kept 3 days after our preliminary experiment showed injection.This with the application of delivering before not the experimental data of glucosan of the same race be consistent.
The influence that observation is expressed the splenocyte surface molecular shows to have only the CD4+ lymphocyte to be influenced.The composite preparation of glucosan and resveratrol again demonstrates synergism.Use that affected CD4+ lymphocyte returns to normal level after 3 days.
Except the direct effect to the immune system various kinds of cell, the immunoregulation effect of beta glucan is owing to cytokine such as TNF α, IFN γ, and the synthetic and release of IL-1 produces.The activity of this activated cell factor depends on the triple helix structure.The generation that most glucosan can both stimulate TNF-α in the experiment in vitro in vivo.We infer that glucosan is to strengthen lymphocyte function through the secretion that increases TNF α, are particularly infecting in early days.There is research to think that some IL-2 of mechanism of resveratrol inhibiting or the alpha mediated function of TNF-are the interactional circumstantial evidence of resveratrol-cytokine.Therefore, especially meaningful for the evaluation of three kinds of potential systematic effects of pattern cytokine.Dosage and the time point confirmed before adopting, we have observed the release of resveratrol and inductive IL-1 of glucan composition and IL-6.In addition, the associating reagent of glucosan and resveratrol composition not only demonstrates synergism, also stimulates the release of TNF-α, and this has more than is to receive the resveratrol composition result of effect separately.
The traditional chemotherapy and/or the side effect of radiotherapy are that leukopenia and significant immune system suppress, and this is serious problem for tumour patient.These side effects limit the treatment dosage and frequency.We are verified, and oral glucosan can be strengthened the cytothesis of experimental leukopenia, and the treatment after the radiotherapy also obtains similar experimental data.Have experiment to show recently, the glucosan in oral yeast source can improve the reparation leukopenia.According to the strong cooperative effect that laboratory observation before us arrives, adopt the model of the immune cell destruction of 5-fluorouracil foundation, we have found a strong preventive effect of oral glucosan, these effects are likely what CR-3 mediated.Glucosan is to the effect of hematopoietic cell: at bone marrow, singly use with the resveratrol composition influence limitedly, synergism is not obvious.At spleen, we observe condition of different.Though glucosan shows higher activity than resveratrol, also be to show the repairing activity higher from the 4th day to the splenocyte structure.Combined application glucosan and resveratrol then demonstrate stronger synergism.
The purposes of prescription of the present invention is used for enhancing immunity, blood fat reducing, blood sugar lowering, anti-oxidation function.Be specially adapted to the old and feeble crowd's of hyperglycemia, hyperlipidemia, cancer and needs prevention dietetic therapy and prevention and health care.
The present invention is raw materials used can both to buy from market; Used resveratrol raw material is a trans-resveratrol; The effective ingredient of yeast dextran is 1-3; The 6-beta glucan (with patented technology with extractings such as the most of protein in the thalline, fat after, appoint the right complete cellular morphology of yeast that keeps, the natural physiological active function that is had of performance beta glucan).
The present invention requires to protect scope to be not limited only to the description of the foregoing description.
Claims (7)
1. an alimentation composition that is used for health care is characterized in that being made up of resveratrol, yeast dextran; Resveratrol, yeast dextran compatibility relationship are resveratrol 20～350mg, yeast dextran 50～1500mg.
2. a kind of alimentation composition that is used for health care according to claim 1 is characterized in that resveratrol 40mg, yeast dextran 1000mg.
3. a kind of alimentation composition that is used for health care according to claim 1 is characterized in that resveratrol 60mg, yeast dextran 500mg.
4. a kind of alimentation composition that is used for health care according to claim 1 is characterized in that resveratrol 150mg, yeast dextran 250mg.
5. a kind of alimentation composition that is used for health care according to claim 1 is characterized in that resveratrol 300mg, yeast dextran 150mg.
6. a kind of alimentation composition that is used for health care according to claim 1 is characterized in that resveratrol 20mg, yeast dextran 1500mg.
7. a kind of alimentation composition that is used for health care according to claim 1 is characterized in that resveratrol 350mg, yeast dextran 50mg.
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| CN106806380A (en) * | 2017-01-03 | 2017-06-09 | 汉济生物科技（武汉）有限公司 | A kind of pharmaceutical composition with reduction blood sugar effect |
| CN114796259B (en) * | 2022-02-17 | 2024-06-07 | 泉州雷恩生化有限公司 | Medicine for inhibiting pulmonary nodule and inflammation and its prepn |
| CN115530289A (en) * | 2022-09-27 | 2022-12-30 | 深圳壹零捌生物工程科技有限公司 | Compound life cell nutrient for pets |
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| CN1439377A (en) * | 2002-02-21 | 2003-09-03 | 北京龙兴科技股份有限公司 | Composition for improvement of osteoporosis |
| CN101249081A (en) * | 2008-02-15 | 2008-08-27 | 南京大渊美容保健有限公司 | Administer orally controlled release drug administration pharmaceutical tablet |
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| CN1439377A (en) * | 2002-02-21 | 2003-09-03 | 北京龙兴科技股份有限公司 | Composition for improvement of osteoporosis |
| CN101249081A (en) * | 2008-02-15 | 2008-08-27 | 南京大渊美容保健有限公司 | Administer orally controlled release drug administration pharmaceutical tablet |
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