CN103710264A - Auxiliary additive for wall breaking of Mythic Fungus spores - Google Patents
Auxiliary additive for wall breaking of Mythic Fungus spores Download PDFInfo
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- CN103710264A CN103710264A CN201310674828.0A CN201310674828A CN103710264A CN 103710264 A CN103710264 A CN 103710264A CN 201310674828 A CN201310674828 A CN 201310674828A CN 103710264 A CN103710264 A CN 103710264A
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Abstract
The invention discloses an auxiliary additive for the wall breaking of Mythic Fungus spores. The auxiliary additive comprises, by weight, 100 parts of diethylamine, 45-48 parts of citric acid, 20-24 parts of oxalic acid, 10-13 parts of vitamin E, 1-5 parts of yeast nucleic acid and 0.5-2 parts of amylase. The auxiliary additive for the wall breaking of Mythic Fungus spores allows cell walls of the Mythic Fungus spores to rapidly form a porous structure during ultrasonic wall breaking, so effective components in cells are rapidly released, and the wall breaking rate can reach 98%.
Description
Technical field
The present invention relates to a kind of plant tissue decomposition agent.
Background technology
Glossy ganoderma, property is sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Cure mainly consumptive disease, cough, asthma, insomnia, maldigestion, malignant tumour etc.Animal pharmacology shows experiment: glossy ganoderma has restraining effect to neural system, and the recycle system has step-down and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, protects in addition liver, improves immunologic function, antibacterially waits effect.According to animal experiment, small white mouse is had to calmness, analgesic activity.Can improve that small white mouse is cold-resistant, hypoxia-bearing capability, and postpone its death time.The glossy ganoderma of take is equipped with the Chinese medicines such as the bighead atractylodes rhizome, pseudo-ginseng, Ligusticum wallichii as main, can significantly improve the survival rate of animal, and can help animal to tide over radiation syndrome crisis, and white corpuscle is early recovered.Exposure animal can improve a poor appetite after taking glossy ganoderma, improves the mental status.20 grams of the oral glossy ganodermas of normal people, can reduce heart rate.Main Function has:
Low or the imbalance of antitumor action autoimmune function is the major reason why tumour can occur and expand.Glossy ganoderma is that best immunologic function regulates and activator, and it can significantly improve the immunologic function of body, strengthens patient's self anti-cancer ability.Glossy ganoderma can be by promoting the generation of interleukin II, by the phagocytic function of promotion mononuclear macrophage, by promoting the especially leukocytic index level of hematopoietic potential of human body, and by the restraining effect of some effective constituent to cancer cells wherein, become the preferred agents of antitumor, anti-cancer and assistant treating cancer.Glossy ganoderma to human body almost without any toxic side effect.The advantage of this avirulent immune activation agent, many tumor chemotherapeutic drugs and other immunopotentiating agent do not have exactly.Two, the liver injury that protecting liver and detoxication effect glossy ganoderma causes multiple physics and chemistry and biotic factor has provide protection.After no matter still occurring before liver damage occurs, take glossy ganoderma and all can protect liver, alleviate liver injury.Glossy ganoderma can promote the metabolism of liver to medicine, poisonous substance, for toxic hepatitis, has definite curative effect.Especially chronic hepatitis, glossy ganoderma can obviously be eliminated the symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and can effectively improve liver function, makes indices be tending towards normal.So glossy ganoderma can be used for treating chronic poisoning, all kinds of chronic hepatitis, liver cirrhosis, hepatic insufficiency.Three, effect experimentation on animals and the clinical trial of cardiovascular systems are all shown; glossy ganoderma is coronary artery dilator effectively; increase coronary flow; improve Myocardial Microcirculation; strengthen the supply of myocardium oxygen and energy; therefore, myocardial ischemia is had to provide protection, can be widely used in treatment and the prevention of coronary heart diseases and angina pectoris etc.To high fat of blood patient, glossy ganoderma can obviously reduce blood cholesterol, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, have and reduce Arterial Cholesterol content, vessel softening, prevent the further effect of damage.And can improve local microcirculation, stop platelet aggregation.These effects have good preventive and therapeutic effect for polytype apoplexy.Four, the contained polysaccharide of anti-aging effects glossy ganoderma, polypeptide etc. have obvious function of delaying senility.This effect is mainly based on following mechanism: 1, promote and adjustment immunologic function.For grownup and the elderly, this promotion and adjustment can obviously delay senility.For the children in growth and development stage, can promote the perfect of its immunologic function, strengthen resistance against diseases, guarantee that it grows up healthy and sound.2, regulate metabolic balance, promote the synthetic of nucleic acid and protein.Research shows, serum, liver and the nucleic acid of marrow and the biosynthesizing of protein when glossy ganoderma can be urged therefore can be effectively disease-resistant anti-aging.Observation shows, takes glossy ganoderma with anti-ageing, not only useful to the elderly, the personage of business age level is suitable for, because the process of growing is namely moved towards old and feeble process.3, anti-radical action.(as superoxide-dismutase, reduction SOD), is a reason of human senility for the antioxidant of the interior originality defence radical damage that organism produces or antioxidant enzyme material.Ganoderan has significant plan SOD active, can significantly remove the free radical that body produces, thereby stops the damage of radical pair body, has prevented the peroxidation of fat body, has protected cell, has delayed cell aging.4, ganoderan can show chopsticks promotion cell nuclear dna synthesis capability, and can increase the division algebraically of cell, thereby has delayed the aging of body.Five, neurasthenia effect glossy ganoderma is just for neurasthenia and insomnia, therefore it plays good effect to maincenter.Extract energy exciting motion suppresses, mobility is reduced, make coordinated movement imbalance, present the sick effect in dose-dependent town, hexobarbital sleep interaction energy is curtailed sleep, central nervous system stimulants caffeine be can extend and spasm and dead time caused, these results show, glossy ganoderma is inhibition effect to maincenter.The motherland contained glossy ganoderma of medicine can " be calmed the nerves ", " increasing wisdom ", " not forgetting ".It is reported, to neurasthenia, insomnia has significant curative effect to Ganoderma preparation, and total effective rate is up to 87.14%～100%.After general medication, within 10～15 days, occur obvious curative effects, be indicated as sleep improvement, appetite, body weight increase, and palpitaition, headache, dizziness alleviate or disappear, in high spirits, hypermnesia.Belong to qi-blood deficiency person's better efficacy.So glossy ganoderma has stronger regulating effect for central nervous system, there is the effect of tranquilizing and allaying excitement, for the weak and insomniac of remarkable ability, be indispensable good merchantable brand, in state-promulgated pharmacopoeia, glossy ganoderma is exactly the medicine of effectively sleeping peacefully and allaying excitement.< < Shennong Bencaojing > > classifies glossy ganoderma as top grade, and " clothes are made light of one's life by commiting suicide and always do not prolonged life for a long time for main deafness, sharp joint; protect god's benefit essence; hard muscles and bones, good color to call purple sesame." " bowl spares increases wisdom not to be forgotten for main knot in the heart, the beneficial motive, and food of a specified duration is made light of one's life by commiting suicide not old, prolongs life and becomes an immortal to call red sesame." in recent years; to the research of Ganoderma lucidum seu Japonicum as emerged rapidly in large numbersBamboo shoots after a spring rain; clinical report is a lot of; be summed up following several respects: (1) controls chronic bronchitis: take Investigation of Lingzhi Tablets, days 3 times, each 1 (content is equivalent to 0.5 gram of crude drug); or with glossy ganoderma tincture (20% concentration); day 3 times, each 10 milliliters (every feed ration is equivalent to 6 grams of crude drugs), general 15～30 days start to take effect.(2) control bronchial asthma: 1～2 milliliter of pediatric patient intramuscular injection every day (every milliliter containing 0.5～1 gram of crude drug), inject about 1 month continuously.(3) control leukopenia: once treat leukopenia 52 examples that cause because of various factorss such as chemistry, physics, medicine and chronic diseases, in the recent period efficient is 84.6%, and total white blood cells is on average increased to 1028/ cubic millimeter.It within 10～20 days, is a course for the treatment of.(4) treatment coronary heart disease: to stenocardia, that pareordia is swollen is vexed, or the remission rate of sense of compression is about 72%, the improvement rate of the symptoms such as palpitaition, shortness of breath is about to 65%, patient's period in a medicine reflections more than half: appetite, sleep, spirit take a turn for the better, reducing blood triglyceride has good therapeutic effect.Clinical trial all shows, glossy ganoderma is coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; myocardial ischemia is had to provide protection, can be widely used in treatment and the prevention of coronary heart diseases and angina pectoris etc.To high fat of blood patient, glossy ganoderma can obviously reduce blood cholesterol, lipoprotein and triglyceride, and the formation of energy prevention of arterial atherosclerotic plaque.For atherosclerotic plaque former, have and reduce Arterial Cholesterol content, vessel softening, prevent the further effect of damage.And can improve local microcirculation, stop platelet aggregation.These effects have good preventive and therapeutic effect for polytype apoplexy.(5) treatment irregular pulse: in the process by glossy ganoderma treatment coronary heart disease, find when coronary heart disease is improved, the irregular pulse of following also, along with taking a turn for the better and disappearing, so adopt Ganoderma Ludicum Injection to treat various irregular pulse, obtains certain effect.(6) control acute viral hepatitis, better than traditional " protecting liver " curative effect of medication.In addition, be also used for the treatment of atrophic gastritis, malignant tumour etc.(7) neurasthenia.The contained glossy ganoderma of motherland's medical science can " be calmed the nerves ", " increasing wisdom ", " not forgetting ".It is reported, Ganoderma preparation is had a sleepless night to have to neurasthenia and is being shown curative effect, and total effective rate is up to 87.14%～100%.After general medication, within 10～15 days, occur obvious curative effects, be indicated as sleep improvement, appetite, body weight increase, and palpitaition, headache, dizziness alleviate or disappear, in high spirits, hypermnesia.Belong to qi-blood deficiency person's better efficacy.So glossy ganoderma has stronger regulating effect for central nervous system, there is the effect of tranquilizing and allaying excitement, for neurasthenia and insomniac, be indispensable good merchantable brand, in state-promulgated pharmacopoeia, glossy ganoderma is exactly the medicine of effectively sleeping peacefully and allaying excitement.(8) treatment diabetes: the hypoglycemic principle of glossy ganoderma is owing to promoting tissue to sugared utilization.After taking glossy ganoderma, disengaging of Regular Insulin inhibition lipid acid can be replaced, the symptoms such as blood sugar, glucose in urine can be improved.Blood sugar is down to 116 by 173, and cholesterol is down to 179, β-albumen by 233 and is down to 465 by 580.Water-soluble polysaccharide in glossy ganoderma, can alleviate the occurring degree of non insulin dependent diabetes.The ganoderma health-care food that Japan Numata Kenji produces, has been widely used treatment diabetic subject.(9) anti-allergic effects: cause immunologic function hyperfunction when body is subject to certain antigen invasion and attack, while producing various transformation reactions or autoimmune pathology infringement, glossy ganoderma can suppress hyperfunction immune level, keeps the stable of body self.Experimental results show that: the release of glossy ganoderma anaphylaxis medium capable of blocking, prevent anaphylactoid generation, therefore, for the more difficult allergy of current treatment or autoimmune disorder.As: allergic asthma, lupus erythematosus, hyperthyroidism, allergic rhinitis, multiple refractory skin etc. all can play good effect, and can partly resist the toxic side effect that some Disease occurs because of life-time service hormone.(10) treatment rheumatic and rheumatoid: glossy ganoderma has in rheumatism and similar rheumatism clinical application must curative effect, glossy ganoderma is to playing a role clearly in the adjusting of autoimmunity and physiological function, complicated according to the theory of traditional Chinese medical science rheumatoid arthritis cause of disease, belong to Chinese medical ' arthralgia syndrome ' category.Numbness is that obstructed meaning is closed in resistance, and the heresy that chill is damp and hot, attacks human body in an opponent's defence, causes QI-blood circulation not smooth, and meridian stasis is stagnant; The generation of numbness disease also has substantial connection with the prosperity and decline of physique and climatic condition, living environment in addition., all once there was research the aspects such as difference of our Endocrine, metabolism, nutrition, geography, occupation, psychology and society environment with the relation of rheumatoid arthrosis morbidity.Bacterium and virus infection and heredity, because of rope, may also have certain relation with morbidity.Generally acknowledge that at present rheumatoid arthritis is a kind of autoimmune disorder.Wall breaking technology Ganoderma powder is taken and 2 ~ 3 courses for the treatment of rheumatic and rheumatoid is had to obvious improvement in clinical patients, and obvious effective rate is in 78% left and right.As can be seen here, the disease of Ganoderma lucidum seu Japonicum treatment, major part is the illness of senile, intractable, degenerative.
Ganoderma spore brown, avette, one end is truncate, (8.5～ll.2) um * (5. 2-6. 9) um, tool double wall.Brown internal layer at each spore produces many needle-like pimples, stretches into dearly the transparent outer layer of conidial cell wall, and outer sporoderm is smooth.Very tough and tensile, the general chemistry of two layers of walls of Ganoderma spore parcel, physical method is difficult to be broken, therefore limited the research to its chemical composition, bioactive ingredients.Set up effective wall-breaking method, can promote the research to the extraction of its bioactive ingredients and pharmaceutical use.
The chemical composition of Ganoderma spore can be divided into following a few class: protein and amino acids, glycopeptide class, vitamins, carotene, sterols, triterpenes, alkaloids, fatty acid, lactone and mineral ion etc.Glossy ganoderma spore gives protein content and reaches 18%, and wherein the content of the body indispensable amino acid such as Isoleucine, leucine Methionin, α-amino-isovaleric acid, methionine(Met), phenylalanine is very abundant, all from reaching 10 g/kg.Vitamins is mainly vitamin-E (VE), and in every 100 g spores, VE content surpasses 60mg, also contains in addition a small amount of vitamins C.In Ganoderma spore, be rich in polysaccharide and oligosaccharides, wherein the content of disaccharides, trisaccharide, tetrose is respectively 1. 94,1.67 and 2.5 mg/g.Steroid has ergot steroid-7,22-ethene-3 β alcohol (ergosta-7,22-diene-3-ol) and β-sitosterol.From the acidic extraction thing of red Ganoderma lucidum spore powder, also separation has obtained some triterpene compounds, and they are Ganosporeric acid A, B, C, E (ganosporeic acid A, B, C, E) and ganodenn anon-Trol.And constantly in Ganoderma spore, find new triterpene substance, these materials have good biological activity.Fatty acid in the exhausted son of glossy ganoderma has Lignoceric acid, stearic acid, palmitinic acid, docosoic acid etc.Its lactone generic pentacyclic triterpene lactones, has ganosporelactione A and B.Alkaloids has amine salt in choline, trimethyl-glycine and sulphur Histidine methyl.Inorganic elements has calcium, phosphorus, iron, magnesium, sodium, zinc, germanium selenium etc., and wherein organic germanium and the mankind's key health and the control of disease have substantial connection.
The wall breaking technology of Ganoderma spore is the determinative of its drug effect quality, and in prior art, the broken wall that can differentiate spore by opticmicroscope whether.The conidial cell wall of broken wall is smooth not complete, and after broken wall treatment, conidial cell wall is imperfect, and content is irregular bulk.External multipurpose high-pressure air-flow method broken wall, its equipment one-time investment is large and fragile.Method time length, the broken wall damage of this broken wall are large, and sporoderm-broken rate is low.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defect, and the broken wall supplementary additive of the Ganoderma spore that sporoderm-broken rate is high is provided.
Object of the present invention is carried out specific implementation by the following technical programs:
A broken wall supplementary additive for Ganoderma spore, its component by weight, 100 parts of diethylamine, citric acid 45-48 part, oxalic acid 20-24 part, vitamin-E 10-13 part, yeast nucleic acid 1-5 part, amylase 0.5-2 part.
As preferred version, the broken wall supplementary additive of above-mentioned Ganoderma spore, its component by weight, 100 parts of diethylamine, 46.5 parts of citric acids, 21 parts of oxalic acid, 12.5 parts of vitamin-Es, 4.5 parts of yeast nucleic acids, 0.5 part of amylase.
The broken wall supplementary additive of above-mentioned Ganoderma spore, is generally applied in supersonic wave wall breaking process, and the material that needs broken wall is immersed in broken wall supplementary additive, and stir on ultrasonic concussion limit, limit.
Beneficial effect of the present invention:
The broken wall supplementary additive of Ganoderma spore provided by the present invention, can make the cell walls of Ganoderma spore in ultrasonication, form fast vesicular structure, thereby the effective constituent in cell is discharged fast, and sporoderm-broken rate can reach 98%.
Embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
embodiment 1:
A broken wall supplementary additive for Ganoderma spore, its component by weight, 100 parts of diethylamine, 46.5 parts of citric acids, 21 parts of oxalic acid, 12.5 parts of vitamin-Es, 4.5 parts of yeast nucleic acids, 0.5 part of amylase.
embodiment 2:
A broken wall supplementary additive for Ganoderma spore, its component by weight, 100 parts of diethylamine, 45 parts of citric acids, 24 parts of oxalic acid, 10 parts of vitamin-Es, 5 parts of yeast nucleic acids, 0.5 part of amylase.
embodiment 3:
A broken wall supplementary additive for Ganoderma spore, its component by weight, 100 parts of diethylamine, 48 parts of citric acids, 20 parts of oxalic acid, 13 parts of vitamin-Es, 1 part of yeast nucleic acid, amylase 2 part.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (2)
1. a broken wall supplementary additive for Ganoderma spore, is characterized in that: its component by weight, 100 parts of diethylamine, citric acid 45-48 part, oxalic acid 20-24 part, vitamin-E 10-13 part, yeast nucleic acid 1-5 part, amylase 0.5-2 part.
2. the broken wall supplementary additive of Ganoderma spore according to claim 1, is characterized in that: its component by weight, 100 parts of diethylamine, 46.5 parts of citric acids, 21 parts of oxalic acid, 12.5 parts of vitamin-Es, 4.5 parts of yeast nucleic acids, 0.5 part of amylase.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104073344A (en) * | 2014-07-16 | 2014-10-01 | 江苏斯威森生物医药工程研究中心有限公司 | Extracting method for ganoderma lucidum spore oil |
| CN108148677A (en) * | 2017-12-28 | 2018-06-12 | 晨光生物科技集团股份有限公司 | A kind of continuous extraction method of pepper oleoresin |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104073344A (en) * | 2014-07-16 | 2014-10-01 | 江苏斯威森生物医药工程研究中心有限公司 | Extracting method for ganoderma lucidum spore oil |
| CN104073344B (en) * | 2014-07-16 | 2016-08-24 | 江苏斯威森生物医药工程研究中心有限公司 | A kind of extracting method of Ganoderma spore oil |
| CN108148677A (en) * | 2017-12-28 | 2018-06-12 | 晨光生物科技集团股份有限公司 | A kind of continuous extraction method of pepper oleoresin |
| CN108148677B (en) * | 2017-12-28 | 2021-06-08 | 晨光生物科技集团股份有限公司 | Continuous extraction method of pepper oleoresin |
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