CN105999248A - Hirudin medicinal liquor and preparation method and application thereof - Google Patents
Hirudin medicinal liquor and preparation method and application thereof Download PDFInfo
- Publication number
- CN105999248A CN105999248A CN201610423007.3A CN201610423007A CN105999248A CN 105999248 A CN105999248 A CN 105999248A CN 201610423007 A CN201610423007 A CN 201610423007A CN 105999248 A CN105999248 A CN 105999248A
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- CN
- China
- Prior art keywords
- hirudin
- chinese liquor
- medicated wine
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- preparation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Provided is a hirudin medicinal liquor. 400-600 g of fresh hirudin extracted from leeches is soaked in 30-40 degrees of 500 ML baijiu, sealed storage is performed to obtain a mother liquor, and then the mother liquor is diluted with the baijiu into the hirudin medicinal liquor. The baijiu can be baijiu of various degrees, the baijiu of more than 40 degrees is more ideal, and the baijiu of more than 50 degrees is recommended. The hirudin medicinal liquor can be used for treatment of thrombosis, hyperlipidemia and hypertension.
Description
Technical field
The present invention relates to a kind of medicated wine, more particularly to the medicated wine of a kind of hirudin preparation.
The invention still further relates to the preparation method of above-mentioned hirudin medicated wine.
The invention still further relates to above-mentioned Hirudo vegetarian feast in terms for the treatment of thrombotic disease, high fat of blood, hypertension
Application.
Background technology
Hirudin is the activity with the strongest blood coagulation resisting function extracted from Hirudo (being commonly called as Hirudo)
Composition, has been used for extensively carrying out the research treating various thrombus diseases, such as:
Anticoagulation and antithrombotic；
Reduce surface activity of blood platelet, suppress platelet aggregation, reduce platelet adhesion reaction；
Reduce blood viscosity；
Reduce blood fat etc..
From the point of view of comprehensive existing report, owing to the hirudin extracted is generally liquid, it is therefore desirable to
It is processed making dry powdery or lamellar by liquid hirudin, during to preserving longer
Between, then make injection and oral agents etc. further according to demand.
During hirudin is processed, inevitably reduce biological activity in hirudin,
Thus reduce the curative effect of hirudin.
Summary of the invention
It is an object of the invention to provide a kind of hirudin medicated wine.
It is yet another object of the invention to provide a kind of method preparing above-mentioned hirudin medicated wine.
For achieving the above object, the hirudin medicated wine that the present invention provides is to be obtained by following method:
1) the fresh hirudin that 400g-600g Hirudo is extracted is steeped the 500ML Chinese liquor in 30-40 degree
Middle sealed type storage, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to the hirudin medicated wine of arbitrary proportion.
In described hirudin medicated wine, step 1 be by 500g Hirudo extract fresh hirudin steep in
Sealed type storage in the 500ML Chinese liquor of 30 degree.
In described hirudin medicated wine, the Chinese liquor of step 2 is the Chinese liquor of more than 50 degree.
The method preparing above-mentioned hirudin medicated wine that the present invention provides is；
1) the fresh hirudin that 400g-600g Hirudo is extracted is steeped the 500ML Chinese liquor in 30-40 degree
Middle sealed type storage, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to the hirudin medicated wine of arbitrary proportion.
In described preparation method, step 1 is to steep the fresh hirudin that 500g Hirudo is extracted in 30
Sealed type storage in the 500ML Chinese liquor of degree.
In described preparation method, the Chinese liquor of step 2 is the Chinese liquor of more than 50 degree.
The hirudin medicated wine of the present invention may be used for treating thrombotic disease, high fat of blood, hypertension.
The hirudin medicated wine of the present invention can keep the biological activity of hirudin to greatest extent, is used for adjusting
Joint blood fat, eliminate fatty liver, directly dissolve thrombosis, eliminate atherosclerosis, prevent apoplexy and again
Secondary apoplexy, the corroded rock mass of human activin self, it is to avoid again produce thrombolytic etc..
Detailed description of the invention
Fresh hirudin is dissolved in Chinese liquor by the present invention, makes hirudin medicated wine, had both overcome Hirudo
The strange taste of element, can retain again the biological activity of hirudin.
Hirudin itself has a kind of fishy smell, and Chinese liquor then taste is pure and sweet, and end opening makes us aftertaste, simultaneously wine
Also it is a kind of good organic solvent, there is preferable penetrance.Wine can make major part water-soluble substances,
And some water can not dissolve the Cucumber maybe needing could to dissolve with nonpolar solvent and be dissolved in wine (second
Alcohol) in.This effect can make wine be easier to enter in Chinese crude drug histiocyte, by portion big in Chinese crude drug
Various different organic substances are divided to be dissolved out, to play the original therapeutical effect of crude drug.
The medicated wine that wine is made after also having antisepsis, wine and Chinese Medicine and Clavicular, can play to greatest extent
The effect of Chinese medicine, has again preferable stability.Scientific investigations showed that, when ethanol content is more than 18%
Time, the hydrolytic spoilage of medicine can be delayed, strengthen the stability of medicament.The highest containing amount of alcohol, medicament
Anti-corrosive properties the highest.So, medicated wine is easier long-term storage, is suitable for old and chronic disease
The long-term taking of patient.
Chinese liquor itself be food be also a herb, the most just have " length that wine is hundred medicines "
Saying.The research of modern medicine shows: the ethanol (ethanol) in wine can be by the dehydrogenase of alcohol in human body
It is oxidized to acetaldehyde, is then oxidized to acetic acid.This oxidizing process can promote internal blood circulation, makes
Blood flow is accelerated, pulse accelerates, accelerated breathing.Therefore, responsible drinking can increase cell viability, solves
Except fatigue, increase body temperature；Gastrointestinal secretion can also be promoted, help digest.
The present invention is integrated the most molten to hirudin and Chinese liquor, forms a kind of existing therapeutical effect, again
There is the beverage of health care.The hirudin medicated wine made both can treat disease, may be used for again after being ill
Auxiliary treatment, moreover it is possible to play diseases prevention and be healthy and strong, the anti-ageing effect prolonged life.
Hereinafter the invention will be further described in citing:
Joining in low alcohol white spirit by the known method fresh hirudin of extraction and shake up, bottle sealing is stored
A period of time makes hirudin thoroughly be dissolved in Chinese liquor, makes mother solution, then takes Shi Zaiyong at needs white
Wine is diluted by the actual needs drunk, and i.e. obtains the medicated wine of fresh hirudin.
It is the low alcohol white spirit with 30-40 degree that the present invention prepares the low alcohol white spirit of mother solution, the fresh water of addition
The amount of trematodiasis element is to occur without saturated being as the criterion, and the present invention preferably scheme is to be extracted by 400g-600g Hirudo
Fresh hirudin steep in 30 degree of 500ML low alcohol white spirits and to store more than three months at cool place.Relatively
It is preferably every 500ML low alcohol white spirit and adds the hirudin that 500g Hirudo is extracted, after storing four months
It is diluted to arbitrary proportion with Chinese liquor again take.
The number of degrees of the present invention Chinese liquor for diluting mother solution do not have considered critical, can be the various number of degrees
Grain neutral spirit (such as jowar wine, corn wine etc.), specifically can be according to the tolerance ethanol ability of drinking person
Fixed, the drinking person that tolerance ethanol ability is relatively low can be used low alcohol white spirit, higher to tolerance ethanol ability
Drinking person can use high spirit.For the effect of medicated wine, preferably more than 40 degree
Chinese liquor, it is recommended that use the Chinese liquor of more than 50 degree.
The hirudin medicated wine of following example is first to steep the fresh hirudin that 500g Hirudo is extracted in 30
After in degree 500ML low alcohol white spirit, at cool place, storage makes mother solution in four months, dense according still further to 400ML
Degree be the Chinese liquor of 56 degree adds the hirudin medicated wine that 100ML mother solution is made as a example by.
Embodiment 1
Obtain sufferers themselves to agree to, 8 are suffered from slight thrombus sequela and limbs inconvenience (mainly
Lower limb or the arm of side have feeling of numbness) patient compare.Comparison group 1 is that three people control according to known
Treatment method takes the commercially available medicine containing hirudin, and comparison group 2 is the water that remaining five people drinks the present invention
Trematodiasis element medicated wine, morning and evening every day each 50ML.After 5 days, five people's limbs of comparison group 2 feel there is different journey
The raising of degree, comparison group 1 limbs after nine days feel the raising having in various degree.
Embodiment 2
Obtaining sufferers themselves to agree to, the patient that 5 blood fat are higher respectively takes the 50ML present invention every day sooner or later
Hirudin medicated wine, after 7 days detect blood fat all have decline in various degree.
Embodiment 3
Obtain sufferers themselves to agree to, 6 are suffered from hypertension and the most dizzy patient is the most each for every day
Take the hirudin medicated wine of the 50ML present invention.Take dizzy sense in 3 days substantially to alleviate, after 5 days, measure blood
Pressure tends to normal.
Claims (9)
1. a hirudin medicated wine, is obtained by following method:
1) the fresh hirudin that 400g-600g Hirudo is extracted is steeped the 500ML Chinese liquor in 30-40 degree
Middle sealed type storage, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to hirudin medicated wine.
Hirudin medicated wine the most according to claim 1, wherein, step 1 is by 500g Hirudo
The fresh hirudin extracted steeps sealed type storage in the 500ML Chinese liquor of 30 degree.
Hirudin medicated wine the most according to claim 1, wherein, the Chinese liquor of step 2 is 50 degree
Above Chinese liquor.
4. the preparation method of hirudin medicated wine described in claim 1；
1) the fresh hirudin that 400g-600g Hirudo is extracted is steeped the 500ML Chinese liquor in 30-40 degree
Middle sealed type storage, makes mother solution；
2) the mother solution Chinese liquor of step 1 is diluted to hirudin medicated wine.
Preparation method the most according to claim 4, wherein, step 1 is to be carried by 500g Hirudo
The fresh hirudin taken steeps sealed type storage in the 500ML Chinese liquor of 30 degree.
Preparation method the most according to claim 4, wherein, the Chinese liquor of step 2 be 50 degree with
On Chinese liquor.
7. the application in preparation treatment thrombotic disease medicine of the hirudin medicated wine described in claim 1.
8. the application in preparation treatment high fat of blood medicine of the hirudin medicated wine described in claim 1.
9. hirudin medicated wine application in preparing Hypertension medicine described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610423007.3A CN105999248A (en) | 2016-06-14 | 2016-06-14 | Hirudin medicinal liquor and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610423007.3A CN105999248A (en) | 2016-06-14 | 2016-06-14 | Hirudin medicinal liquor and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999248A true CN105999248A (en) | 2016-10-12 |
Family
ID=57087628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610423007.3A Pending CN105999248A (en) | 2016-06-14 | 2016-06-14 | Hirudin medicinal liquor and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999248A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3432596A (en) * | 1967-10-13 | 1969-03-11 | Dresden Arzneimittel | Method for producing highly pure hirudine |
| CN101019964A (en) * | 2007-02-05 | 2007-08-22 | 周维海 | Health wine with leech and its production process |
| CN102085357A (en) * | 2011-01-14 | 2011-06-08 | 重庆时珍阁普生药业有限公司 | Purpose of medicine adopting hirudin and hementerin as raw materials |
| CN102964446A (en) * | 2012-11-28 | 2013-03-13 | 周维官 | Method for repeatedly extracting natural hirudin from live vampire leech |
-
2016
- 2016-06-14 CN CN201610423007.3A patent/CN105999248A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3432596A (en) * | 1967-10-13 | 1969-03-11 | Dresden Arzneimittel | Method for producing highly pure hirudine |
| CN101019964A (en) * | 2007-02-05 | 2007-08-22 | 周维海 | Health wine with leech and its production process |
| CN102085357A (en) * | 2011-01-14 | 2011-06-08 | 重庆时珍阁普生药业有限公司 | Purpose of medicine adopting hirudin and hementerin as raw materials |
| CN102964446A (en) * | 2012-11-28 | 2013-03-13 | 周维官 | Method for repeatedly extracting natural hirudin from live vampire leech |
Non-Patent Citations (3)
| Title |
|---|
| 吴渊清: "怎样浸制药酒", 《老友》 * |
| 周进科；刘翠萍: "凝血酶抑制剂——水蛭素", 《中国新药杂志》 * |
| 欧兴长等: "水蛭素的研究概况", 《中国药学杂志》 * |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161012 |