CN105998997A - Oral liquid and preparation method thereof - Google Patents
Oral liquid and preparation method thereof Download PDFInfo
- Publication number
- CN105998997A CN105998997A CN201610326269.8A CN201610326269A CN105998997A CN 105998997 A CN105998997 A CN 105998997A CN 201610326269 A CN201610326269 A CN 201610326269A CN 105998997 A CN105998997 A CN 105998997A
- Authority
- CN
- China
- Prior art keywords
- herba cistanches
- water
- slag
- distilled water
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses an oral liquid and a preparation method thereof and relates to the field of processing of healthcare products. The method comprises steps as follows: weighed raw materials are crushed and mixed, and a mixture is obtained; the mixture is put into distilled water, soaked at the normal temperature firstly, then heated to be boiling, cooled and kept at the temperature, and a water extract of the mixture and water extract residues of the mixture are obtained after temperature keeping ends; the water extract of the mixture, the water extract residues of the mixture, a desertliving cistanche alcohol extract and origin pulp liquor are mixed, and a solid-liquid mixture is obtained; the solid-liquid mixture is placed at the normal temperature for 25-35 days, and mixed residues and a mixed liquid are obtained through solid-liquid separation; the mixed liquid is subjected to static settlement, and a supernatant is taken; ethanol in the supernatant is removed, and the oral liquid is obtained after dilution with water. The oral liquid prepared with the method can resist fatigue and enhance immunity and particularly has the good gestation promoting effect.
Description
Technical field
The present invention relates to health care product manufacture field, particularly relate to a kind of oral liquid and preparation method thereof.
Background technology
In the epoch developed rapidly now, young people, as the main activity crowd of society, is responsible for the heavy burden of cause and family,
Time be often accompanied by overtime work, go on business, be busy with work of fighting, the male that especially sitting computer is other, owing to operating pressure is big, exercise machine meeting
Few, there are various sub-health states in health, as fatigue and weak, lassitude, be too tired to deal with, negative emotions is serious and suffers from a deficiency of the kidney;
Some ages slightly larger middle age also because of work, life, physiology and age reason suffered from hypertension, hyperlipidemia, hyperglycemia,
Arthralgia and the disease such as function of male is impaired.For another example, along with the relieving of national two tire policies, proper quadragenarian family examines
Consider two tires, have no alternative unable to do what one wants very much to do, the most infertile.
For above-mentioned realistic problem, various health preserving wine, health-preserving beverage, health-caring capsule and various fertility drugs etc. occur on the market;Its
In be no lack of some perfunctory products, and it is not expensive for truly having its product, the unable consumption of ordinary people, it is simply that
Have compared with big side effect or sense of discomfort can be produced after taking or medical value is little, DeGrain etc.;Therefore, health preserving is protected by people
Strong product is hung back or is difficult to believe.
Summary of the invention
In view of this, embodiments provide a kind of oral liquid and preparation method thereof, main purpose be to provide a kind of resisting fatigue,
The oral liquid that enhancing immunity, gravidity assisting and side effect are little.
For reaching above-mentioned purpose, invention broadly provides following technical scheme:
On the one hand, embodiments provide the preparation method of a kind of oral liquid, comprise the following steps:
By the raw material pulverizing weighed and mix, obtain compound;
Described compound being put into first soak at room temperature in distilled water, is again heated to boiling, lowers the temperature afterwards and be incubated, insulation obtains after terminating
Slag is carried to the Aqueous extracts of described compound and the water of described compound;
The Aqueous extracts of described compound, the water of described compound are proposed slag, Herba Cistanches alcohol extract and original plasm wine mixing, obtains solid-liquid
Mixture;
Described solidliquid mixture room temperature carries out solid-liquid separation after placing 25-35 days, obtains mixing slag and mixed liquor;
Described mixed liquor, after staticly settling, takes its supernatant;
Remove the ethanol in described supernatant, after dilute with water, obtain oral liquid.
As preferably, described compound time of soak at room temperature in distilled water is 0.5h-1.5h hour, and described compound is steaming
Holding temperature in distilled water is 55 DEG C-65 DEG C, and described compound temperature retention time in distilled water is 0.5h-1.5h;
During described solidliquid mixture room temperature is placed 25-35 days, within every 2-3 days, shake up once;
The time that described mixed liquor staticly settles is 10h-15h;
The described method taking its supernatant is siphonage;Described supernatant is the black liquor without muddy float;
Use rotary film evaporator to pump the ethanol in described supernatant, obtain dark solution, with black described in distilled water diluting
Solution obtains dilute solution;Wherein, the volume ratio of described distilled water and described dark solution is 40-50:1;
Adding edible sodium chloride in dilute solution, the weight ratio of described dilute solution and described edible sodium chloride is 100:15.
As preferably, described original plasm wine is pure corn primary-pulp wine, and in described pure corn primary-pulp wine, the volumn concentration of ethanol is
65%-75%;The adding proportion of described compound, described pure corn primary-pulp wine and described Herba Cistanches alcohol extract is
2200g-2600g:9500mL-10500mL:4500mL-5500mL;The outward appearance of described oral liquid is red.
As preferably, the raw material of described oral liquid includes: total side 1 and Herba Cistanches alcohol extract;Described total side 1 and described Herba Cistanches
The adding proportion of alcohol extract is 2200g-2600g:4500mL-5500mL;
By weight, described total side 1 includes: Maca 250-270 part, Fructus Aurantii 45-55 part, Radix Platycodonis 70-80 part, Radix Glycyrrhizae
55-65 part, Fructus Jujubae 240-260 part, Poria 95-105 part, Japanese raisintree fruit 70-80 part, Semen Lablab Album 55-65 part, Fructus Alpiniae Oxyphyllae
45-55 part, Rhizoma Polygonati 95-105 part, Rhizoma Polygonati Odorati 55-65 part, Radix Puerariae 55-65 part, Fructus Mori 95-105 part, Semen Ziziphi Spinosae 95-105
Part, Concha Ostreae 95-105 part, Fructus Citri Sarcodactylis 45-55 part, Flos Rosae Rugosae 28-32 part, Herba Cirsii 65-75 part, Herba portulacae 70-80 part,
Fructus Lycii 70-80 part, Radix Angelicae Sinensis 45-55 part, Radix Rehmanniae 68-85 part, Semen Persicae 55-65 part, Flos Carthami 45-55 part, Rhizoma Chuanxiong 45-55
Part, Radix Paeoniae Rubra 45-55 part, Radix Achyranthis Bidentatae 50-60 part, Rhizoma Gastrodiae 45-55 part, Radix Salviae Miltiorrhizae 45-55 part, Fructus Ligustri Lucidi 45-55 part.
As preferably, described total side 1 is 2300g-2500g:4800mL-5200mL with the adding proportion of described Herba Cistanches alcohol extract;
By weight, described total side 1 includes: Maca 255-265 part, Fructus Aurantii 48-52 part, Radix Platycodonis 72-78 part, Radix Glycyrrhizae
58-62 part, Fructus Jujubae 245-255 part, Poria 97-103 part, Japanese raisintree fruit 72-78 part, Semen Lablab Album 57-63 part, Fructus Alpiniae Oxyphyllae
48-52 part, Rhizoma Polygonati 97-103 part, Rhizoma Polygonati Odorati 58-62 part, Radix Puerariae 58-62 part, Fructus Mori 97-103 part, Semen Ziziphi Spinosae 97-103
Part, Concha Ostreae 97-103 part, Fructus Citri Sarcodactylis 48-52 part, Flos Rosae Rugosae 29-31 part, Herba Cirsii 68-72 part, Herba portulacae 72-78 part,
Fructus Lycii 72-78 part, Radix Angelicae Sinensis 48-52 part, Radix Rehmanniae 70-78 part, Semen Persicae 58-63 part, Flos Carthami 48-53 part, Rhizoma Chuanxiong 48-53
Part, Radix Paeoniae Rubra 48-53 part, Radix Achyranthis Bidentatae 52-58 part, Rhizoma Gastrodiae 48-52 part, Radix Salviae Miltiorrhizae 48-52 part, Fructus Ligustri Lucidi 45-55 part.
As preferably, described Herba Cistanches alcohol extract is to prepare by comprising the steps:
Herba Cistanches fleshy stem is put in distilled water and carry out soak at room temperature, soak and obtain pretreatment fluid and meat through solid-liquid separation after terminating
Herba Cistanches pretreatment product;
Putting into be heated in distilled water seething with excitement by described Herba Cistanches pretreatment product and be incubated, insulation obtains through solid-liquid separation after terminating
Carrying slag to Herba Cistanches Aqueous extracts and Herba Cistanches water, give up described Herba Cistanches Aqueous extracts, described Herba Cistanches water of selecting and remain carries slag;
Described Herba Cistanches water carries slag put into edible ethanol carries out soak at room temperature, soak and obtain Herba Cistanches through solid-liquid separation after terminating
Alcohol extraction slag and Herba Cistanches alcohol extract, described Herba Cistanches alcohol extract is transparent brown liquid.
As preferably, described Herba Cistanches pretreatment product are put into the process carrying out again being incubated that is heated in distilled water seething with excitement and are specifically included:
First being put into by described Herba Cistanches pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out solid-liquid separation, obtain the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carry slag;
Again described first Herba Cistanches water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out solid-liquid separation after terminating, obtains the second Herba Cistanches Aqueous extracts and the second Herba Cistanches water carries slag;
Giving up described first Herba Cistanches Aqueous extracts and described second Herba Cistanches Aqueous extracts, described second Herba Cistanches water of selecting and remain carries slag;
Described second Herba Cistanches water is carried slag and puts into soak at room temperature in edible ethanol.
As preferably, described Herba Cistanches is dry product Cistanche Tubulosa;The weight of dry product Cistanche Tubulosa fleshy stem is 180g-220g,
The volume of the distilled water used of insulation for the first time is 3000mL-5000mL, and temperature retention time is 1.5h-2.5h for the first time, and second time is protected
The volume of temperature distilled water used is 3000mL-5000mL, and temperature retention time is 2.5h-3.5h for the second time.
As preferably, described Herba Cistanches pretreatment product are put into the process being heated to seething with excitement and be incubated in distilled water and are specifically included:
First being put into by described Herba Cistanches pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out solid-liquid separation, obtain the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carry slag;
Again described first Herba Cistanches water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out solid-liquid separation after terminating, obtains the second Herba Cistanches Aqueous extracts and the second Herba Cistanches water carries slag;
Described second Herba Cistanches water finally carries slag put into distilled water is heated to boiling, be first cooled to 50 DEG C-60 DEG C and carry out the again
Three insulations, third time insulation carries out solid-liquid separation after terminating, obtains the 3rd Herba Cistanches Aqueous extracts and the 3rd Herba Cistanches water carries slag;
Give up described first Herba Cistanches Aqueous extracts, described second Herba Cistanches Aqueous extracts and described 3rd Herba Cistanches Aqueous extracts, institute of selecting and remain
State the 3rd Herba Cistanches water and carry slag;
Described 3rd Herba Cistanches water is carried slag and puts into soak at room temperature in edible ethanol.
As preferably, described Herba Cistanches is dry product Cistanche Tubulosa;Dry product Cistanche Tubulosa fleshy stem soak at room temperature in distilled water
Time be 46h-50h;The dry product Cistanche Tubulosa fleshy stem of every 180g-220g places into after room temperature distilled water immersion
Being heated to boiling in the distilled water of 3000mL-5000mL and be incubated, temperature retention time is 4h-6h;The body of described edible ethanol
Amassing as 4500mL-5500mL, in described edible ethanol, the volumn concentration of ethanol is 65%-75%, and described Herba Cistanches water carries slag
In edible ethanol, the time of soak at room temperature is 25 days-35 days.
On the other hand, the embodiment of the present invention uses said method to prepare a kind of oral liquid.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is directed to health preserving goods propose in the problem that the aspect effects such as resisting fatigue, enhancing immunity, gravidity assisting and side effect are poor
A kind of oral liquid, its active component relates to raw material and the Herba Cistanches alcohol extract of multiple integration of edible and medicinal herbs, by rational proportioning, respectively
Composition passes through synergism, works in coordination, and the oral liquid obtained has no side effect, without sense of discomfort after taking, and can resisting fatigue, enhancing
Immunity, especially gravidity assisting effect is especially good.
Detailed description of the invention
By further illustrating the technological means and effect that the present invention taked by reaching predetermined goal of the invention, below preferably to implement
Example, to the foundation detailed description of the invention of the present patent application, technical scheme, feature and effect thereof, after describing in detail such as.Under state
Special characteristic, structure or feature in multiple embodiments in bright can be combined by any suitable form.
Embodiment 1
Choose Cistanche Tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche Tubulosa fleshy stem of 180g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche Tubulosa fleshy stem out, obtain pre-
Treatment fluid and Herba Cistanches pretreatment product, Herba Cistanches pretreatment product now absorbed water swell quality increase, above-mentioned Herba Cistanches is located in advance
Reason product are cut into the lamellar that thickness is 1cm, obtain lamellar Herba Cistanches pretreatment product;Above-mentioned lamellar Herba Cistanches pretreatment product are put into
The normal-temperature distilled water of 3000mL is heated to boiling, and constantly boiling 4 hours together, i.e. under fluidized state, is incubated 4 hours,
Insulation separates liquid and solid after terminating, and obtains Herba Cistanches Aqueous extracts and Herba Cistanches water carries slag, give up Herba Cistanches Aqueous extracts, select and remain
Herba Cistanches water carries slag, uses manpower that above-mentioned Herba Cistanches water carries slag and dries, removes Herba Cistanches water and carry the excessive moisture on slag surface;Again
Above-mentioned Herba Cistanches water is carried slag put into volume be 4500mL alcoholic strength be 65% edible alcohol solution in (second in edible alcohol solution
The volumn concentration of alcohol is 65%) soak at room temperature takes out after 25 days, obtains Herba Cistanches alcohol extraction slag and transparent reddish brown through solid-liquid separation
The Herba Cistanches alcohol extract of color.
Embodiment 2
Choose Cistanche Tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche Tubulosa fleshy stem of 200g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche Tubulosa fleshy stem out, obtain pre-
Treatment fluid and Herba Cistanches pretreatment product, Herba Cistanches pretreatment product now absorbed water swell quality increase, above-mentioned Herba Cistanches is located in advance
Reason product are cut into the lamellar that thickness is 1cm, obtain lamellar Herba Cistanches pretreatment product;Above-mentioned lamellar Herba Cistanches pretreatment product are put into
The normal-temperature distilled water of 4000mL is heated to boiling, and constantly boiling 2 hours, i.e. insulation 2 for the first time under fluidized state together
Hour, insulation for the first time carries out solid-liquid separation after terminating, and obtains the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carries slag, give up
First Herba Cistanches Aqueous extracts, the first Herba Cistanches water of selecting and remain carries slag, more above-mentioned first Herba Cistanches water is carried slag puts into the normal of 4000mL
First being heated to boiling in temperature distilled water, be cooled to 60 DEG C the most again, above-mentioned first Herba Cistanches water carries slag in the steaming that temperature is 60 DEG C
Soaking in distilled water 3 hours, i.e. second time insulation 3 hours, second time insulation carries out solid-liquid separation after terminating, obtains the second meat desert
Rong's Aqueous extracts and the second Herba Cistanches water carry slag;Giving up above-mentioned second Herba Cistanches Aqueous extracts, above-mentioned second Herba Cistanches water of selecting and remain carries slag,
Use manpower that above-mentioned second Herba Cistanches water carries slag to dry, remove the second Herba Cistanches water and carry the excessive moisture on slag surface;Again by above-mentioned
Second Herba Cistanches water carries slag and puts into edible alcohol solution that 5000mL alcoholic strength the is 71% (volume hundred of ethanol in edible alcohol solution
Point content is 71%) in soak at room temperature take out after 30 days, obtain Herba Cistanches alcohol extraction slag and transparent henna meat desert through solid-liquid separation
Rong's alcohol extract.
Embodiment 3
Choose Cistanche Tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche Tubulosa fleshy stem of 200g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche Tubulosa fleshy stem out, obtain pre-
Treatment fluid and Herba Cistanches pretreatment product, Herba Cistanches pretreatment product now absorbed water swell quality increase, above-mentioned Herba Cistanches is located in advance
Reason product are cut into the lamellar that thickness is 1.5cm, obtain lamellar Herba Cistanches pretreatment product;Above-mentioned lamellar Herba Cistanches pretreatment product are put into
The normal-temperature distilled water of 4500mL is heated to boiling, and constantly boiling 2.5 hours, i.e. insulation for the first time under fluidized state together
2.5 hours, insulation for the first time carried out solid-liquid separation after terminating, and obtains the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carries slag,
Giving up the first Herba Cistanches Aqueous extracts, the first Herba Cistanches water of selecting and remain carries slag, more above-mentioned first Herba Cistanches water is carried slag puts into 4500mL
Normal-temperature distilled water in first be heated to boiling, be cooled to 62 DEG C the most again, it is 62 DEG C that above-mentioned first Herba Cistanches water carries slag in temperature
Distilled water in soak 3 hours, i.e. second time insulation 3 hours, second time insulation terminate after carry out solid-liquid separation, obtain second
Herba Cistanches Aqueous extracts and the second Herba Cistanches water carry slag;Giving up above-mentioned second Herba Cistanches Aqueous extracts, above-mentioned second Herba Cistanches water of selecting and remain carries
Slag, uses manpower that above-mentioned second Herba Cistanches water carries slag and dries, remove the second Herba Cistanches water and carry the excessive moisture on slag surface;Again will
Above-mentioned second Herba Cistanches water carries slag and puts into edible alcohol solution that 5000mL alcoholic strength the is 70% (body of ethanol in edible alcohol solution
Long-pending percentage composition is 70%) in soak at room temperature take out after 32 days, obtain Herba Cistanches alcohol extraction slag and transparent henna through solid-liquid separation
Herba Cistanches alcohol extract.
Embodiment 4
Choose Cistanche Tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche Tubulosa fleshy stem of 220g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche Tubulosa fleshy stem out, obtain pre-
Treatment fluid and Herba Cistanches pretreatment product, Herba Cistanches pretreatment product now absorbed water swell quality increase, above-mentioned Herba Cistanches is located in advance
Reason product are cut into the lamellar that thickness is 2cm, obtain lamellar Herba Cistanches pretreatment product;Above-mentioned lamellar Herba Cistanches pretreatment product are put into
The normal-temperature distilled water of 5000mL is heated to boiling, and constantly boiling 2 hours, i.e. insulation 2 for the first time under fluidized state together
Hour, insulation for the first time carries out solid-liquid separation after terminating, and obtains the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carries slag, give up
First Herba Cistanches Aqueous extracts, the first Herba Cistanches water of selecting and remain carries slag, more above-mentioned first Herba Cistanches water is carried slag puts into the normal of 5000mL
First being heated to boiling in temperature distilled water, be cooled to 65 DEG C the most again, above-mentioned first Herba Cistanches water carries slag in the steaming that temperature is 65 DEG C
Soaking in distilled water 2 hours, i.e. second time insulation 2 hours, second time insulation carries out solid-liquid separation after terminating, obtains the second meat desert
Rong's Aqueous extracts and the second Herba Cistanches water carry slag, give up above-mentioned second Herba Cistanches Aqueous extracts, and above-mentioned second Herba Cistanches water of selecting and remain carries slag;
Above-mentioned second Herba Cistanches water carries slag again put into the normal-temperature distilled water of 5000mL is first heated to boiling, is cooled to 60 DEG C the most again,
Above-mentioned second Herba Cistanches water carries slag and soaks in the distilled water that temperature is 60 DEG C 2 hours, i.e. third time insulation 2 hours, for the third time
Insulation carries out solid-liquid separation after terminating, and obtains the 3rd Herba Cistanches Aqueous extracts and the 3rd Herba Cistanches water carries slag;Use manpower by above-mentioned the
Three Herba Cistanches water carry slag and dry, and remove the 3rd Herba Cistanches water and carry the excessive moisture on slag surface;Again above-mentioned 3rd Herba Cistanches water is carried slag
Put in the edible alcohol solution (in edible alcohol solution, the volumn concentration of ethanol is 75%) that 5500mL alcoholic strength is 75%
Soak at room temperature took out after 35 days, obtained Herba Cistanches alcohol extraction slag and transparent henna Herba Cistanches alcohol extract through solid-liquid separation.
Embodiment 5
Cistanche Tubulosa extracting solution embodiment 1-embodiment 4 prepared is diluted to the liquid that alcoholic strength is 40 degree, and (ethanol is at liquid
Volumn concentration in body is 40%), obtain No. 1 liquid, No. 2 liquid, No. 3 liquid and No. 4 liquid, ask 20 one-tenth
Year, male took aforesaid liquid before sleep, 20 male is divided into four groups, often organizes 5 people, and first group of male takes 100mL
No. 1 liquid, second group of male takes No. 2 liquid of 100mL, and the 3rd group of male takes No. 3 liquid of 100mL, the 4th
Group male takes No. 4 liquid of 100mL, within second day, investigates the physiology impression of these four groups of people, all represents that sleep quality is preferable, body
The heart is without sense of discomfort, and second day hale and hearty, and state is preferable.
Embodiment 6
Accurately weigh following raw material: Maca 250g, Fructus Aurantii 45g, Radix Platycodonis 70g, Radix Glycyrrhizae 55g, Fructus Jujubae 240g, Poria 95g,
Japanese raisintree fruit 70g, Semen Lablab Album 55g, Fructus Alpiniae Oxyphyllae 45g, Rhizoma Polygonati 95g, Rhizoma Polygonati Odorati 55g, Radix Puerariae 55g, Fructus Mori 95g, Semen Ziziphi Spinosae
95g, Concha Ostreae 95g, Fructus Citri Sarcodactylis 45g, Flos Rosae Rugosae 28g, Herba Cirsii 65g, Herba portulacae 70g, Fructus Lycii 70g, Radix Angelicae Sinensis 48g, the Radix Rehmanniae
70g, Semen Persicae 58g, Flos Carthami 48g, Rhizoma Chuanxiong 48g, Radix Paeoniae Rubra 48g, Radix Achyranthis Bidentatae 52g, Rhizoma Gastrodiae 48g, Radix Salviae Miltiorrhizae 48g, Fructus Ligustri Lucidi
45g, the mixing of above-mentioned each raw material is as total side 1;
By above-mentioned each raw material pulverizing and mix, obtain compound, above-mentioned compound is put into room temperature leaching in the distilled water of 5000mL
After steeping 1 hour, being further continued for being heated to boiling, be cooled to 55 DEG C subsequently and be incubated 1 hour at such a temperature, insulation obtains after terminating
Slag is carried to the Aqueous extracts of compound and the water of compound;The Aqueous extracts of above-mentioned compound and the water of compound are carried slag and puts into glass jar
In, then in glass jar, add the pure corn primary-pulp wine that 9500mL alcoholic strength is 65% (volumn concentration of ethanol is 65%),
Adding the Herba Cistanches alcohol extract of 5500mL again in glass jar, obtain solidliquid mixture, above-mentioned Herba Cistanches alcohol extract is above-mentioned reality
Execute the Herba Cistanches alcohol extract that example 1 prepares, above-mentioned solidliquid mixture room temperature in glass jar is placed, during placement every three days
Shake up once, shake up again once after 25 days, the solidliquid mixture in glass jar is filtered, obtain mixing slag and mixed liquor,
Above-mentioned mixed liquor poured in glass container and staticly settles 11 hours, after being layered, taking its supernatant with siphonage, on this
Clear liquid is the black liquor without muddy float, uses rotary film evaporator to pump the ethanol in above-mentioned supernatant, obtains black
Solution, is the ratio of 40:1 according to volume ratio, obtains dilute solution by the above-mentioned dark solution of distilled water diluting, to above-mentioned dilution
Solution adds the edible sodium chloride of its weight 15%, (i.e. the weight ratio of dilute solution and edible sodium chloride is 100:15), mixed
Closing and uniformly obtain oral liquid, this oral liquid outward appearance is red, the breath of micro-hardship, slightly sweet taste and direction;Fill according to 15mL every
Entering in ampere bottle, obtain bottled oral liquid, this oral liquid is primarily adapted for use in alcohol intolerance crowd.
Embodiment 7
Accurately weigh following raw material: Maca 260g, Fructus Aurantii 50g, Radix Platycodonis 75g, Radix Glycyrrhizae 60g, Fructus Jujubae 250g, Poria 100g,
Japanese raisintree fruit 75g, Semen Lablab Album 60g, Fructus Alpiniae Oxyphyllae 50g, Rhizoma Polygonati 100g, Rhizoma Polygonati Odorati 60g, Radix Puerariae 60g, Fructus Mori 100g, Semen Ziziphi Spinosae
100g, Concha Ostreae 100g, Fructus Citri Sarcodactylis 50g, Flos Rosae Rugosae 30g, Herba Cirsii 70g, Herba portulacae 75g, Fructus Lycii 75g, Radix Angelicae Sinensis 50g,
Radix Rehmanniae 75g, Semen Persicae 60g, Flos Carthami 50g, Rhizoma Chuanxiong 50g, Radix Paeoniae Rubra 50g, Radix Achyranthis Bidentatae 55g, Rhizoma Gastrodiae 50g, Radix Salviae Miltiorrhizae 50g, Fructus Ligustri Lucidi
Sub-50g, the mixing of above-mentioned each raw material is as total side 1;
By above-mentioned each raw material pulverizing and mix, obtain compound, above-mentioned compound is put into room temperature leaching in the distilled water of 5000mL
After steeping 1 hour, being further continued for being heated to boiling, be cooled to 60 DEG C subsequently and be incubated 1 hour at such a temperature, insulation obtains after terminating
Slag is carried to the Aqueous extracts of compound and the water of compound;The Aqueous extracts of above-mentioned compound and the water of compound are carried slag and puts into glass jar
In, then in glass jar, add the pure corn primary-pulp that 10000mL alcoholic strength is 71% (volumn concentration of ethanol is 71%)
Wine, then in glass jar, add the Herba Cistanches alcohol extract of 5000mL, obtaining solidliquid mixture, above-mentioned Herba Cistanches alcohol extract is upper
State the Herba Cistanches alcohol extract that embodiment 2 prepares, above-mentioned solidliquid mixture room temperature in glass jar is placed, every during placement
Within three days, shake up once, shake up again once after 30 days, the solidliquid mixture in glass jar is filtered, obtain mixing slag and mixing
Liquid, pours in glass container by above-mentioned mixed liquor and staticly settles 12 hours, after being layered, taking its supernatant with siphonage,
This supernatant is the black liquor without muddy float, uses rotary film evaporator to pump the ethanol in above-mentioned supernatant, obtains
Dark solution, is the ratio of 45:1 according to volume ratio, obtains dilute solution by the above-mentioned dark solution of distilled water diluting, to above-mentioned
Dilute solution adds the edible sodium chloride of its weight 15%, (i.e. the weight ratio of dilute solution and edible sodium chloride is 100:15),
Mix homogeneously obtains oral liquid, and this oral liquid outward appearance is red, the breath of micro-hardship, slightly sweet taste and direction;According to 15mL every
Loading in ampere bottle, obtain bottled oral liquid, this oral liquid is primarily adapted for use in alcohol intolerance crowd.
Embodiment 8
Accurately weigh following raw material: Maca 270g, Fructus Aurantii 55g, Radix Platycodonis 80g, Radix Glycyrrhizae 65g, Fructus Jujubae 260g, Poria 105g,
Japanese raisintree fruit 80g, Semen Lablab Album 65g, Fructus Alpiniae Oxyphyllae 55g, Rhizoma Polygonati 105g, Rhizoma Polygonati Odorati 65g, Radix Puerariae 65g, Fructus Mori 105g, Semen Ziziphi Spinosae
105g, Concha Ostreae 105g, Fructus Citri Sarcodactylis 55g, Flos Rosae Rugosae 32g, Herba Cirsii 75g, Herba portulacae 80g, Fructus Lycii 80g, Radix Angelicae Sinensis 55g are raw
Ground 85g, Semen Persicae 65g, Flos Carthami 55g, Rhizoma Chuanxiong 55g, Radix Paeoniae Rubra 55g, Radix Achyranthis Bidentatae 60g, Rhizoma Gastrodiae 55g, Radix Salviae Miltiorrhizae 55g, Fructus Ligustri Lucidi
50g, the mixing of above-mentioned each raw material is as total side 1;
By above-mentioned each raw material pulverizing and mix, obtain compound, above-mentioned compound is put into room temperature leaching in the distilled water of 5000mL
After steeping 1 hour, being further continued for being heated to boiling, be cooled to 65 DEG C subsequently and be incubated 1 hour at such a temperature, insulation obtains after terminating
Slag is carried to the Aqueous extracts of compound and the water of compound;The Aqueous extracts of above-mentioned compound and the water of compound are carried slag and puts into glass jar
In, then in glass jar, add the pure corn primary-pulp that 10500mL alcoholic strength is 75% (volumn concentration of ethanol is 75%)
Wine, then in glass jar, add the Herba Cistanches alcohol extract of 4500mL, obtaining solidliquid mixture, above-mentioned Herba Cistanches alcohol extract is upper
State the Herba Cistanches alcohol extract that embodiment 3 prepares, above-mentioned solidliquid mixture room temperature in glass jar is placed, every during placement
Within three days, shake up once, shake up again once after 35 days, the solidliquid mixture in glass jar is filtered, obtain mixing slag and mixing
Liquid, pours in glass container by above-mentioned mixed liquor and staticly settles 13 hours, after being layered, taking its supernatant with siphonage,
This supernatant is the black liquor without muddy float, uses rotary film evaporator to pump the ethanol in above-mentioned supernatant, obtains
Dark solution, is the ratio of 50:1 according to volume ratio, obtains dilute solution by the above-mentioned dark solution of distilled water diluting, to above-mentioned
Dilute solution adds the edible sodium chloride of its weight 15%, (i.e. the weight ratio of dilute solution and edible sodium chloride is 100:15),
Mix homogeneously obtains oral liquid, and this oral liquid outward appearance is red, the breath of micro-hardship, slightly sweet taste and direction;According to 15mL every
Loading in ampere bottle, obtain bottled oral liquid, this oral liquid is primarily adapted for use in alcohol intolerance crowd.
Embodiment 9
Select the effect of the oral liquid that four representative women are prepared with testing example 7 as subject, above-mentioned four
Name subject before the oral liquid taking the present invention in sub-health state or have some common senile disease etc., concrete condition
As follows:
First case: 46 years old women Wang, government civilian, drinks oral liquid more than 50 sky, and period reaction lumbago phenomenon disappears,
The leg gonalgia significantly alleviates, and has cut out arthritis oral medicine, and skin of face becomes full smooth, and body weight increases
Two kilograms, there are acne in scalp;
Second case: women defended so-and-so in 76 years old, retired employees of enterprise people from Shandong, take oral liquid half a year, myalgia transference cure,
Muscle power energy takes a turn for the better, and thinking is apparent from, and the light of change of walking, half a year does not catches a cold;
3rd example: 75 years old women clump so-and-so, enterprise retired worker, live Tianshan District, Urumchi, take oral liquid more than 60 sky,
Night sweat phenomenon disappears, and face is ruddy, and arthralgia significantly alleviates, hip joint, and during leg joint motions, abnormal sound disappears;
4th example: 74 years old Liu women so-and-so, enterprise retired worker, live Shuimogou District, Urumchi, take oral liquid 3 months,
Face by sallow transfer to ruddy full, reaction audition increase, energetic.
Comparative example 1
200g main flower herba cistanches is soaked in the ethanol solution that 5000mL alcoholic strength is 71%, takes out after soaking 30 days,
To Cistanche Tubulosa extracting solution, then this extracting solution is diluted to liquid (the ethanol volume hundred in a liquid that alcoholic strength is 40 degree
Dividing content is 40%), obtain No. 5 liquid;
Comparative example 2
From a kind of Herba Cistanches oral liquid of market buying, processing method is: Herba Cistanches drying and crushing sieved, and adds filtering residue weight
6-8 times of volume pure water, supersound extraction 1 hour, after filtration, filtering residue is carried out second extraction, the Extraction solvent of twice extraction,
Extraction time is all identical with extraction process for the first time with extracting method, merges twice filtrate, concentrates the filtrate to the 1/5 of original volume,
Obtain the aqueous extract of Herba Cistanches;By filtering residue with the ethanol ultrasonic extraction 2 times of 70%, each 1 hour, refilter, merge filter
Liquid is also concentrated into the 1/5 of original volume, obtains the alcohol extract of Herba Cistanches;By aqueous extract and the alcohol of Herba Cistanches of above-mentioned Herba Cistanches
Extracting solution merges, liquid liquid (the ethanol volumn concentration in a liquid being diluted to alcoholic strength 40 degree after merging
It is 40%), obtain No. 6 liquid.
Comparative example 3
No. 5 and No. 6 liquid comparative example 1-comparative example 3 prepared, ask 20 adult males same in embodiment 5 to be tried out
Personnel take above-mentioned diluent before sleep, and first group of male takes No. 5 liquid of 100mL, and second group of male takes 100mL
No. 6 liquid, within second day, investigate the physiology impression of these three groups of people, all represent that head makes a sound in a grand fashion when just starting, dizzy dizzy heavy,
As flood tide, head two vascellum laterale sudden distension in the abdomen, and then heart touches and beats rapidly, extremely feels bad, falls asleep night some hours
After more have heart to accelerate suddenly to beat, make people wake up with a start from sleep state, heart again bang bang make a sound, after general ten a few minutes, slightly return
Calmness, falls asleep again, the most twice or thrice after tranquil just now fall asleep.
Provide commercially available of above-mentioned comparative example 1 and comparative example 2 or from Herba Cistanches Deserticolae (processed) goods, all can be by human consumption, taking dose
All in the range of safety using amount, its effect is mainly used in building body.Therefore, the present inventor is by comparative example 1 and comparative example 2
Herba Cistanches goods allow person on probation take, by embodiment 5 and the personal experiences of the person on probation of comparative example 3, the present invention
The Herba Cistanches extracting solution sense of discomfort of preparation is less, the most non-stimulated to heart, does not affect ortho sleep, edible rear hale and hearty;
And human heart is stimulated relatively big by the Herba Cistanches goods of comparative example 1 and comparative example 2 preparation after eating, have a strong impact on ortho sleep,
After edible, emotion is restless.
Herba Cistanches is powerful well-known with function for tonifying kidney, Compendium of Material Medica record: time treasure say this thing mend and the highest, therefore have from
Appearance number.Calmly, gentle looks;But this book is recorded with a piece the most simultaneously: good Gu says gate of vitality fire deficiency person mutually, mends it with this,
Be kidney channel blood system medicine also.All Herba Cistanchess that takes, to control kidney, must hamper the heart (modern explanation: harm the function of heart).Ancients early have research,
Take Herba Cistanches the kidney invigorating can but be unfavorable for human heart simultaneously;For another example containing Herba Cistanches in certain whole nation famous brand name health promoting wine, its note
This wine is not suitable for Patients with Cardiovascular/Cerebrovascular Diseases just to have one to show in meaning item;Understand, the most in ancient times or modern times, people
All recognize that Herba Cistanches the kidney invigorating can be unfavorable for human heart simultaneously, and in the preparation technology of modern health wine product, all fail solution make
Herba Cistanches can weaken again its technical problem stimulating human heart while reaching the kidney invigorating.But, Herba Cistanches has activation kidney
Upper gland, the function of release 17-hydroxy-11-dehydrocorticosterone, its mechanism of action is the function strengthening Hypothalamus-pituitary, and Herba Cistanches can make animal red carefully
The activity of born of the same parents' superoxide dismutase (SOD) is remarkably reinforced, and can repair heart, liver damage cell, and cerebral tissue can be delayed to decline
Old degeneration, has the liver protecting and promotes the effect of physical efficiency recovery, can obviously improve myocardial infarction phenomenon, improving in cardiac muscular tissue
Creatine phosphokinase vigor, has protection ischemic myocardium effect, can the recovery of hemopoietic;In sum, meat desert
Rong, in addition to having the tradition effects such as kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation, also has antioxidation, radioprotective, improves memory
Deng effect, to the most protected effects such as the heart, brain, lung, liver, kidney and immune systems.And for Patients with Cardiovascular/Cerebrovascular Diseases, meat
Above-mentioned effect in Herba Cistanches is conducive to treating cardiovascular and cerebrovascular disease, but because the defect of prior art also cannot overcome Herba Cistanches to be unfavorable for
The technical problem of human heart, causes Herba Cistanches originally to can be used for helping treatment cardiovascular and cerebrovascular disease, but makes because of the defect of prior art
Herba Cistanches goods stimulate human heart, and make Patients with Cardiovascular/Cerebrovascular Diseases cannot take Herba Cistanches goods, and then make it lose one
The approach for the treatment of cardiovascular and cerebrovascular disease, the most unfortunately.
The present invention is directed to limit due to Herba Cistanches goods cardiac stimulus Patients with Cardiovascular/Cerebrovascular Diseases can not use Herba Cistanches goods with
For treating the technical problem of its disease, by confrontational technological design, the extraction process of Herba Cistanches extracting solution is improved, first
Herba Cistanches fleshy stem is soaked in water, then carries out water carry with the distilled water of boiling, give up Aqueous extracts, Herba Cistanches medicinal residues of selecting and remain, then
Medicinal residues are put into edible ethanol carries out alcohol extraction, obtain the Herba Cistanches extracting solution of the present invention;Wherein, make with recovery Herba Cistanches filtrate
The present invention unlike the traditional handicraft of extracting solution the Aqueous extracts of Herba Cistanches is given up need not, and directly utilize the medicinal residues after water carries
Carry out alcohol extraction again, use above-mentioned technique, by Herba Cistanches immersion and water are carried, can be by large number of biological alkali and inorganic salt in Herba Cistanches
Carry in composition water and isolate, greatly reduce the alkaloid in Herba Cistanches medicinal residues and inorganic salt content, also reduce alkaloid and
Inorganic salts ingredients is to the intense stimulus of heart and remains the organic compound ingredient in Herba Cistanches simultaneously;Therefore, the meat of the present invention
Herba Cistanches extracting solution is less to cardiac stimulation, is applicable to cardiovascular and cerebrovascular vessel crowd, and can increase Herba Cistanches interpolation in its goods
Ratio;Such as, owing to fearing the Herba Cistanches intense stimulus to heart, generally, in 5000mL71 degree medicated wine, Herba Cistanches is former
Material safety using amount is 30g-50g, and can be containing the Herba Cistanches raw material of 180-220g in the edible ethanol of 5000mL of the present invention, phase
Under Bi, by the process modification of the present invention, in the edible ethanol of same volume, its safe handling amount is greatly improved;Due to meat desert
The raising of Rong's safe handling amount, making to be suitable for crowd's scope increases, and has also given full play to its bigger medical value, has better met
The demand of people, especially meets the demand of Patients with Cardiovascular/Cerebrovascular Diseases, helps treatment cardiovascular and cerebrovascular disease for which increasing one
Approach, the most preferably promote the development of Herba Cistanches industry.
The preparation method of a kind of Herba Cistanches extracting solution that the embodiment of the present invention provides, wherein puts into distillation by Herba Cistanches fleshy stem dry product
Water carries out soak at room temperature, in order to biltong Herba Cistanches is bubbled open, and remove be mixed in various surface impurity therein, its water consumption without
Particular requirement, as long as fully bubbling open Herba Cistanches fleshy stem dry product.
Herba Cistanches pretreatment product put into normal-temperature distilled water be heated to the mistake being incubated again of seething with excitement together in embodiment of the present invention method
Journey, can be carried out once;Such as, Herba Cistanches pretreatment product are put into after normal-temperature distilled water is heated to boiling together, and constantly boiling
4-6 hour, obtain Herba Cistanches water and carry slag;This technique can meet the alkaloid in Herba Cistanches and inorganic salts material water are carried and divided
The requirement separated out.
Herba Cistanches pretreatment product put into normal-temperature distilled water be heated to the mistake being incubated again of seething with excitement together in embodiment of the present invention method
Journey, can be carried out twice;Such as, Herba Cistanches pretreatment product are put into after normal-temperature distilled water is heated to boiling together, and carry out first
Secondary insulation, temperature retention time is 1.5h-2.5h hour, obtains the first Herba Cistanches water and carries slag, the first Herba Cistanches water is carried slag and puts into often
After temperature distilled water is heated to boiling together, then it is cooled to 55 DEG C-65 DEG C, carries out second time at such a temperature and be incubated, during insulation
Between be 2.5h-3.5h hour, obtain the second Herba Cistanches water and carry slag;Wherein, temperature retention time preferably 2 hours for the first time, for the second time
Temperature retention time preferably 3 hours;Use above-mentioned twice extraction process by water, can be fully by the alkaloid in Herba Cistanches and inorganic salts material
Water carries and isolates;Wherein, the purpose of second time cooling is major part alkaloid and inorganic after boiled water puies forward process through first time
Salts substances is proposed by water, then carries out second time water and carry, if also using boiled water to carry, and may also can be by a small amount of organic substance
Water proposes, in order to retain the organic substance in Herba Cistanches as far as possible, in second time water carries, by near for water temperature 55 DEG C-65 DEG C,
At a temperature of Gai, i.e. can reach abundant water and carry alkaloid remaining in Herba Cistanches and inorganic salts material, it is possible to retain Herba Cistanches as possible
In organic substance.
Herba Cistanches pretreatment product put into normal-temperature distilled water be heated to the mistake being incubated again of seething with excitement together in embodiment of the present invention method
Journey, also can be carried out three times;After the insulation of above-mentioned second time terminates, the second Herba Cistanches water is carried slag and puts in distilled water and heat together
To seething with excitement and being cooled to 50 DEG C-60 DEG C, be incubated at such a temperature, separated after obtain the 3rd Herba Cistanches water and carry slag;Pass through
Three water carries and overwhelming majority alkaloids and inorganic salts material water can be proposed and filter out by the technique progressively lowered the temperature, greatly reduces
Water carries alkaloid and the content of inorganic salts material in slag, also remains the organic substance in Herba Cistanches, in order to Herba Cistanches fills
Its medical value is waved in distribution.
Above-mentioned twice water puies forward process and three water put forward process, and the water of even more than three times puies forward process all can meet technology requirement, but examines
Consider to Cost Problems, it is preferred to use twice and the water lowered the temperature step by step put forward process and can preferably meet the requirement of the present invention.
In embodiment of the present invention method by the 180g-220g Herba Cistanches frequent warm water soaking of fleshy stem dry product 48 hours, place into
The distilled water of 3000mL-5000mL is heated to boiling and carries out being incubated for the first time, in said process, and Herba Cistanches fleshy stem dry product weight
Amount and the distilled water soaked have certain proportionate relationship, it is desirable to alkaloid and inorganic salts material in dry product can not be at distilled water
In reach saturated, this saturation can by specialty detection analytical equipment obtain, if distilled water is very few, the most saturated, in Herba Cistanches
Alkaloid and inorganic salts material fully can not be carried by water and filter out, and affect the medicinal effects of later stage extracting solution, to cardiac stimulation
Degree may also can exist, and therefore, the present inventor obtains using above-mentioned adding proportion by great many of experiments and data analysis, not only
Saving the water yield can avoid again the alkaloid in distilled water and inorganic salts material to reach saturated, dry product and steaming in insulating process for the second time
The ratio of distilled water is identical with first time.
In the method for the embodiment of the present invention, Herba Cistanches water is carried slag and puts into soak at room temperature 25-35 days in edible ethanol, wherein, food
Being 65%-75% with the volumn concentration of ethanol in ethanol, the present inventor selects the alcohol concentration of above-mentioned 65%-75%, is because
The organic principle in Herba Cistanches dissolution rate in the ethanol solution that concentration is 65%-75% is maximum, in above-mentioned concentration range, and meat
The main component the working health i.e. organic compound that Herba Cistanches contains can be proposed by alcohol fully in a large number from Herba Cistanches,
To Herba Cistanches alcohol extract in organic principle i.e. medicinal ingredient more, medical value is maximum;The present inventor is divided by great many of experiments
Analysis, Herba Cistanches water preferably carrying slag and is soaked in the volumn concentration of ethanol is the Herba Cistanches obtained time in the edible ethanol of 71%
Organic matter content in alcohol extract is maximum, and this content can be obtained by specialty detection analytical equipment.
The method of the embodiment of the present invention is applicable to polytype Herba Cistanches, due to the local Cistanche Tubulosa yield of the present inventor relatively
The most more typically, the present inventor only carries out the extraction process of the present invention with Cistanche Tubulosa for representing raw material.
Cistanche Tubulosa in the embodiment of the present invention can be the most freezing, or dry, or fresh, it is contemplated that fresh
Herba Cistanches be difficult to preserve and cost is relatively big, present invention preferably employs air-dried Cistanche Tubulosa and carry out technique extraction.
The Herba Cistanches extracting solution prepared by Particular craft of the present invention is the most non-stimulated to human heart, improves the safety of Herba Cistanches
Usage amount, has given full play to the medical value of Herba Cistanches, extends the application crowd of Herba Cistanches goods, promotes sending out of Herba Cistanches
Exhibition, has driven the economic development in the Herba Cistanches place of production.
The present invention is directed to health care product in the poor problem of the aspect effects such as resisting fatigue, enhancing immunity, gravidity assisting and side effect,
Propose the preparation method of a kind of oral liquid, the method the oral liquid prepared can resisting fatigue and enhancing immunity, side effect is less,
Especially gravidity assisting effect is especially good.The method comprises the following steps: weigh each raw material by formula, is pulverized and mixes, being mixed
Close material;Compound being put into first soak at room temperature in distilled water, is again heated to boiling, lowers the temperature afterwards and be incubated, insulation obtains after terminating
The Aqueous extracts of compound and the water of compound carry slag;The water of the Aqueous extracts of compound, compound is carried slag, Herba Cistanches alcohol extract and
Original plasm wine mixes, and obtains solidliquid mixture;Solidliquid mixture room temperature carries out solid-liquid separation after placing 25-35 days, obtains mixing slag
And mixed liquor;Mixed liquor, after staticly settling, takes its supernatant;Remove the ethanol in supernatant, be administered orally after dilute with water
Liquid.
Preferred as above-described embodiment, the oral liquid of the present invention is formulated, wherein, always by total side 1 and Herba Cistanches alcohol extract
Side 1 is 2200g-2600g:4500mL-5500mL, preferably 2400g:5000mL with the mixed proportion of Herba Cistanches alcohol extract;Press
Weight portion meter, Maca 250-270 part, Fructus Aurantii 45-55 part, Radix Platycodonis 70-80 part, Radix Glycyrrhizae 55-65 part, Fructus Jujubae 240-260
Part, Poria 95-105 part, Japanese raisintree fruit 70-80 part, Semen Lablab Album 55-65 part, Fructus Alpiniae Oxyphyllae 45-55 part, Rhizoma Polygonati 95-105 part,
Rhizoma Polygonati Odorati 55-65 part, Radix Puerariae 55-65 part, Fructus Mori 95-105 part, Semen Ziziphi Spinosae 95-105 part, Concha Ostreae 95-105 part, Fructus Citri Sarcodactylis
45-55 part, Flos Rosae Rugosae 28-32 part, Herba Cirsii 65-75 part, Herba portulacae 70-80 part, Fructus Lycii 70-80 part, Radix Angelicae Sinensis 45-55
Part, Radix Rehmanniae 68-85 part, Semen Persicae 55-65 part, Flos Carthami 45-55 part, Rhizoma Chuanxiong 45-55 part, Radix Paeoniae Rubra 45-55 part, Radix Achyranthis Bidentatae 50-60
Part, Rhizoma Gastrodiae 45-55 part, Radix Salviae Miltiorrhizae 45-55 part, Fructus Ligustri Lucidi 45-55 part.
Above-mentioned active component relates to the raw material of multiple integration of edible and medicinal herbs, and itself and Herba Cistanches alcohol extract are by rational proportion, logical between each composition
Cross synergism, work in coordination, especially good for resisting fatigue, enhancing immunity and gravidity assisting effect;Owing to this oral liquid using
Medical material major part be pharmaceutically acceptable and edible raw material, it is to avoid various side effect, the oral liquid of preparation also has no side effect;
Herba Cistanches alcohol extract in the present invention can be selected for the technique of routine to be prepared, it is possible to select commercially available Herba Cistanches alcohol extract configuration oral
Liquid, it is mainly composed of Herba Cistanches, and it has and activates adrenal gland, the function of release 17-hydroxy-11-dehydrocorticosterone.
Present invention preferably employs Herba Cistanches alcohol extract prepared by above-mentioned Particular craft, this alcohol extract uses Particular craft to extract, and reduces
Stimulation to heart, is applicable to more crowd.
The Herba Cistanches alcohol extract that the oral liquid of the present invention uses this Particular craft to prepare coordinates other integration of edible and medicinal herbs compositions again, after taking
Without sense of discomfort, hale and hearty, long-term taking can building body, especially good particularly with gravidity assisting effect.Such as, in above-mentioned enforcement
In example 9, four women subjects, by short-term or the oral liquid of the long-term taking present invention, improve sub-health state, improve
Resistance, improves skin.
Oral liquid outward appearance of the present invention is red, micro-hardship, slightly sweet taste and fragrance breath, is primarily adapted for use in alcohol intolerance crowd.
In the oral liquid of the present invention, majority of plant is that industrial crops are produced in Xinjiang, mostly sells as raw material at present, cheap,
Make the oral liquid advantage of lower cost of the present invention, come out by the research of oral liquid of the present invention, perfect Economy in Xinjiang crop industry
Chain, lays the first stone for industrial crops deep processing.
The detailed description of the invention being only the present invention disclosed above, but protection scope of the present invention is not limited thereto, any familiar
Those skilled in the art, in the technical scope that the invention discloses, can readily occur in change or replace, should contain at this
Within the protection domain of invention.Therefore, protection scope of the present invention should be as the criterion with above-mentioned scope of the claims.
Claims (11)
1. the preparation method of an oral liquid, it is characterised in that comprise the following steps:
By the raw material pulverizing weighed and mix, obtain compound;
Described compound being put into first soak at room temperature in distilled water, is again heated to boiling, lowers the temperature afterwards and be incubated, insulation obtains after terminating
Slag is carried to the Aqueous extracts of described compound and the water of described compound;
The Aqueous extracts of described compound, the water of described compound are proposed slag, Herba Cistanches alcohol extract and original plasm wine mixing, obtains solid-liquid
Mixture;
Described solidliquid mixture room temperature carries out solid-liquid separation after placing 25-35 days, obtains mixing slag and mixed liquor;
Described mixed liquor, after staticly settling, takes its supernatant;
Remove the ethanol in described supernatant, after dilute with water, obtain oral liquid.
The preparation method of a kind of oral liquid the most according to claim 1, it is characterised in that described compound is in distilled water
The time of soak at room temperature is 0.5h-1.5h hour, and described compound holding temperature in distilled water is 55 DEG C-65 DEG C, described
Compound temperature retention time in distilled water is 0.5h-1.5h;
During described solidliquid mixture room temperature is placed 25-35 days, within every 2-3 days, shake up once;
The time that described mixed liquor staticly settles is 10h-15h;
The described method taking its supernatant is siphonage;Described supernatant is the black liquor without muddy float;
Use rotary film evaporator to pump the ethanol in described supernatant, obtain dark solution, with black described in distilled water diluting
Solution obtains dilute solution;Wherein, the volume ratio of described distilled water and described dark solution is 40-50:1;
Adding edible sodium chloride in dilute solution, the weight ratio of described dilute solution and described edible sodium chloride is 100:15.
The preparation method of a kind of oral liquid the most according to claim 1, it is characterised in that described original plasm wine is that pure Semen Maydis is former
Slurry wine, in described pure corn primary-pulp wine, the volumn concentration of ethanol is 65%-75%;Described compound, described pure corn primary-pulp
The adding proportion of wine and described Herba Cistanches alcohol extract is 2200g-2600g:9500mL-10500mL:4500mL-5500mL;Described mouth
The outward appearance taking liquid is redness.
4. according to the preparation method of a kind of oral liquid described in any one of claim 1-3, it is characterised in that described oral liquid
Raw material includes: total side 1 and Herba Cistanches alcohol extract;Described total side 1 with the adding proportion of described Herba Cistanches alcohol extract is
2200g-2600g:4500mL-5500mL;
By weight, described total side 1 includes: Maca 250-270 part, Fructus Aurantii 45-55 part, Radix Platycodonis 70-80 part, Radix Glycyrrhizae
55-65 part, Fructus Jujubae 240-260 part, Poria 95-105 part, Japanese raisintree fruit 70-80 part, Semen Lablab Album 55-65 part, Fructus Alpiniae Oxyphyllae
45-55 part, Rhizoma Polygonati 95-105 part, Rhizoma Polygonati Odorati 55-65 part, Radix Puerariae 55-65 part, Fructus Mori 95-105 part, Semen Ziziphi Spinosae 95-105
Part, Concha Ostreae 95-105 part, Fructus Citri Sarcodactylis 45-55 part, Flos Rosae Rugosae 28-32 part, Herba Cirsii 65-75 part, Herba portulacae 70-80 part,
Fructus Lycii 70-80 part, Radix Angelicae Sinensis 45-55 part, Radix Rehmanniae 68-85 part, Semen Persicae 55-65 part, Flos Carthami 45-55 part, Rhizoma Chuanxiong 45-55
Part, Radix Paeoniae Rubra 45-55 part, Radix Achyranthis Bidentatae 50-60 part, Rhizoma Gastrodiae 45-55 part, Radix Salviae Miltiorrhizae 45-55 part, Fructus Ligustri Lucidi 45-55 part.
The preparation method of a kind of oral liquid the most according to claim 4, it is characterised in that described total side 1 and described meat desert
The adding proportion of Rong's alcohol extract is 2300g-2500g:4800mL-5200mL;
By weight, described total side 1 includes: Maca 255-265 part, Fructus Aurantii 48-52 part, Radix Platycodonis 72-78 part, Radix Glycyrrhizae
58-62 part, Fructus Jujubae 245-255 part, Poria 97-103 part, Japanese raisintree fruit 72-78 part, Semen Lablab Album 57-63 part, Fructus Alpiniae Oxyphyllae
48-52 part, Rhizoma Polygonati 97-103 part, Rhizoma Polygonati Odorati 58-62 part, Radix Puerariae 58-62 part, Fructus Mori 97-103 part, Semen Ziziphi Spinosae 97-103
Part, Concha Ostreae 97-103 part, Fructus Citri Sarcodactylis 48-52 part, Flos Rosae Rugosae 29-31 part, Herba Cirsii 68-72 part, Herba portulacae 72-78 part,
Fructus Lycii 72-78 part, Radix Angelicae Sinensis 48-52 part, Radix Rehmanniae 70-78 part, Semen Persicae 58-63 part, Flos Carthami 48-53 part, Rhizoma Chuanxiong 48-53
Part, Radix Paeoniae Rubra 48-53 part, Radix Achyranthis Bidentatae 52-58 part, Rhizoma Gastrodiae 48-52 part, Radix Salviae Miltiorrhizae 48-52 part, Fructus Ligustri Lucidi 45-55 part.
6. according to the preparation method of a kind of oral liquid described in any one of claim 1-3, it is characterised in that described Herba Cistanches alcohol
Extract is to prepare by comprising the steps:
Herba Cistanches fleshy stem is put in distilled water and carry out soak at room temperature, soak and obtain pretreatment fluid and meat through solid-liquid separation after terminating
Herba Cistanches pretreatment product;
Putting into be heated in distilled water seething with excitement by described Herba Cistanches pretreatment product and be incubated, insulation obtains through solid-liquid separation after terminating
Carrying slag to Herba Cistanches Aqueous extracts and Herba Cistanches water, give up described Herba Cistanches Aqueous extracts, described Herba Cistanches water of selecting and remain carries slag;
Described Herba Cistanches water carries slag put into edible ethanol carries out soak at room temperature, soak and obtain Herba Cistanches through solid-liquid separation after terminating
Alcohol extraction slag and Herba Cistanches alcohol extract, described Herba Cistanches alcohol extract is transparent brown liquid.
The preparation method of a kind of oral liquid the most according to claim 6, it is characterised in that described Herba Cistanches pretreatment product
Put into the process carrying out again being incubated that is heated in distilled water seething with excitement to specifically include:
First being put into by described Herba Cistanches pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out solid-liquid separation, obtain the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carry slag;
Again described first Herba Cistanches water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out solid-liquid separation after terminating, obtains the second Herba Cistanches Aqueous extracts and the second Herba Cistanches water carries slag;
Giving up described first Herba Cistanches Aqueous extracts and described second Herba Cistanches Aqueous extracts, described second Herba Cistanches water of selecting and remain carries slag;
Described second Herba Cistanches water is carried slag and puts into soak at room temperature in edible ethanol.
The preparation method of a kind of oral liquid the most according to claim 7, it is characterised in that described Herba Cistanches is dry product pipe
Flower herba cistanches;The weight of dry product Cistanche Tubulosa fleshy stem is 180g-220g, and the volume of the distilled water used of insulation for the first time is
3000mL-5000mL, temperature retention time is 1.5h-2.5h for the first time, and the volume of second time insulation distilled water used is
3000mL-5000mL, temperature retention time is 2.5h-3.5h for the second time.
The preparation method of a kind of oral liquid the most according to claim 6, it is characterised in that described Herba Cistanches pretreatment product
Put into the process being heated to seething with excitement and be incubated in distilled water to specifically include:
First being put into by described Herba Cistanches pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out solid-liquid separation, obtain the first Herba Cistanches Aqueous extracts and the first Herba Cistanches water carry slag;
Again described first Herba Cistanches water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out solid-liquid separation after terminating, obtains the second Herba Cistanches Aqueous extracts and the second Herba Cistanches water carries slag;
Described second Herba Cistanches water finally carries slag put into distilled water is heated to boiling, be first cooled to 50 DEG C-60 DEG C and carry out the again
Three insulations, third time insulation carries out solid-liquid separation after terminating, obtains the 3rd Herba Cistanches Aqueous extracts and the 3rd Herba Cistanches water carries slag;
Give up described first Herba Cistanches Aqueous extracts, described second Herba Cistanches Aqueous extracts and described 3rd Herba Cistanches Aqueous extracts, institute of selecting and remain
State the 3rd Herba Cistanches water and carry slag;
Described 3rd Herba Cistanches water is carried slag and puts into soak at room temperature in edible ethanol.
The preparation method of a kind of oral liquid the most according to claim 6, it is characterised in that described Herba Cistanches is dry product pipe
Flower herba cistanches;Dry product Cistanche Tubulosa fleshy stem time of soak at room temperature in distilled water is 46h-50h;Every 180g-220g's
Dry product Cistanche Tubulosa fleshy stem places into after room temperature distilled water immersion in the distilled water of 3000mL-5000mL and is heated to seething with excitement also
Being incubated, temperature retention time is 4h-6h;The volume of described edible ethanol is 4500mL-5500mL, second in described edible ethanol
The volumn concentration of alcohol is 65%-75%, and it is 25 days-35 that described Herba Cistanches water carries slag time of soak at room temperature in edible ethanol
My god.
11. 1 kinds of oral liquids, it is characterised in that described oral liquid is to use the method described in any one of claim 1-10 to prepare
Obtain.
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CN108936654A (en) * | 2018-06-12 | 2018-12-07 | 北京筑元吉康医药科技有限责任公司 | A kind of health food of strengthen immunity and its application |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107789616A (en) * | 2017-11-13 | 2018-03-13 | 河南工业大学 | A kind of oral liquid of the albumin containing wheat germ and preparation method thereof |
CN108936654A (en) * | 2018-06-12 | 2018-12-07 | 北京筑元吉康医药科技有限责任公司 | A kind of health food of strengthen immunity and its application |
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