CN105832822A - Herba cistanches extracting solution and preparing method thereof - Google Patents
Herba cistanches extracting solution and preparing method thereof Download PDFInfo
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- CN105832822A CN105832822A CN201610326267.9A CN201610326267A CN105832822A CN 105832822 A CN105832822 A CN 105832822A CN 201610326267 A CN201610326267 A CN 201610326267A CN 105832822 A CN105832822 A CN 105832822A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a herba cistanches extracting solution and a preparing method thereof, and relates to the field of plant processing. The problem that a herba cistanches product greatly irritates the heart is solved. The method includes the steps that succulent stems of herba cistanches are put into distilled water and soaked at normal temperature, and after soaking is completed, pretreatment liquid and a herba cistanches pretreatment product are obtained through solid-liquid separation; the herba cistanches pretreatment product is added into distilled water and heated to boiling, then heat preservation is conducted, after heat preservation, a herba cistanches water extracting solution and herba cistanches water extract residues are obtained through solid-liquid separation, the herba cistanches water extracting solution is abandoned, and the herba cistanches water extract residues are selected and reserved; the herba cistanches water extract residues are put into edible alcohol and soaked at normal temperature, after soaking is completed, a herba cistanches alcohol extracting solution and herba cistanches water extract residues are obtained through solid-liquid separation, and the herba cistanches alcohol extracting solution is the herba cistanches extracting solution. The herba cistanches extracting solution prepared through the method has little irritation to the human heart, safe dosage of herba cistanches is increased, and application groups of herba cistanches products are increased.
Description
Technical field
The present invention relates to plant manufacture field, particularly relate to a kind of saline cistanche extract and preparation method thereof.
Background technology
Saline cistanche have the good reputation of desert " ginseng ", is the conventional tonifying kidney and strengthening yang medicine of the successive dynasties traditional Chinese medical science.Saline cistanche is parasitic for many years
Herbaceous plant, happiness parasitizes desert, sand ground, sand dune, the root of salt-soda soil plant, and medicinal part takes its plump fleshy stem.Meat
Desert cistanche is a traditional Chinese medicine, has tonifying kidney and benefiting sperm establishing-Yang effect, and successive dynasties medicine book is the most on the books.Shennong's Herbal is classified as top grade,
" property of medicine opinion " is referred to as benefit marrow, happy color, prolongs life, establishing-Yang, big help." Bencao Jingshu " is referred to as wanting of nourshing kidney replenishing vital essence and blood
Medicine, clothes then fertilizer is good for and is made light of one's life by commiting suicide for a long time, and the effect of kidney-nourishing liver replenishing vital essence and blood is also.Saline cistanche is powerful well-known with function for tonifying kidney, " book on Chinese herbal medicine guiding principle
Mesh " record: time treasure say this thing and mend and the highest, therefore have calm number.Calmly, gentle looks；But this book is remembered with a piece the most simultaneously
Carry: good Gu say the gate of vitality mutually fire deficiency person, mend it with this, be kidney channel blood system medicine also.All desert cistanches that takes, to control kidney, must hamper the heart (existing
In generation, explains: harm the function of heart).
Saline cistanche has corrective action to the regulation of human nerve internal system and control centre-hypothalamic are aging, can improve sun
The empty nutrition of animal, body weight, endurance and cold hardiness etc..Yang deficiency patient is had obvious strong effect and therapeutic action.Meat desert
Rong can improve learning memory disorder, strengthens memory, significantly improves the senile symptom of body, recovers the experience of the elderly, body
Power, delays senility, and promotes the recovery of hemopoietic function of bone marrow, radioresistance；Can diuresis defaecation, improve urinary function, promote that intestines are compacted
Dynamic, suppress large intestine moisture absorption, shorten defecation time；Saline cistanche can promote that hepatic glycogen synthesizes, and has protection liver and promotes body
The effect that can recover.
Based on the application prospect that above-mentioned saline cistanche is good, in order to make full use of its medical value, can first saline cistanche be extracted
To cistanche extracts, it is as intermediate products, can continue to be processed into desertliving cistanche wine, saline cistanche beverage, desertliving cistanche sheet or meat
Desert cistanche powder etc..Wherein, cistanche extracts frequently with technique be that saline cistanche is first pulverized, then add edible wine by a certain percentage
Progress greatly row cold soaking 2-4 days, and through filtering, after merging filtrate, recovered under reduced pressure obtains desertliving cistanche alcohol extract again；The most such as, in system
First prepare saline cistanche aqueous extract during standby saline cistanche beer, saline cistanche drying and crushing is sieved, then addition pure water enters by a certain percentage
The row ultrasonic extraction of twice 60 minutes, finally merges twice filtrate and is concentrated into finite concentration and obtains the aqueous extract of saline cistanche；
The most such as, dry saline cistanche fleshy stem is clayed into power, adds water, refluxing extraction 2 hours, filter, add water backflow 2 times,
Refluxing extraction 1 hour, merges No. 3 extracts, is finally dried to brown ceramic powder, obtains cistanche extracts every time.For upper
Stating and obtaining the common ground of its extract method from saline cistanche fleshy stem is filtrate or the aqueous extract directly recycling saline cistanche.
But the cistanche extracts prepared by above-mentioned technique, can allow people produce sense of discomfort after taking, and especially night can not be normal
Falling asleep, often occur that heart accelerates suddenly to beat, blood flow accelerates, and the most repeatedly could tranquil fall asleep, and this is due to saline cistanche
The discomfort that cardiac stimulation is produced relatively greatly；If adding the saline cistanche of larger proportion in the product, it is not properly suited for suffers from
The crowd of cardiovascular and cerebrovascular disease；Therefore, manufacturer also reduces saline cistanche to the intense stimulus of heart and exists because fearing saline cistanche
Adding proportion in its goods, makes saline cistanche can not give full play to its medical value, and the crowd of use can not be from saline cistanche product
Obtain more beneficiating ingredient, it is impossible to meet the health requirements of people, have impact on the industry development of saline cistanche.
Summary of the invention
In view of this, embodiments providing a kind of saline cistanche extract and preparation method thereof, main purpose is to provide one
The saline cistanche extract less to cardiac stimulation effect.
For reaching above-mentioned purpose, invention broadly provides following technical scheme:
On the one hand, embodiments provide the preparation method of a kind of saline cistanche extract, comprise the following steps:
Saline cistanche fleshy stem is put in distilled water and carry out soak at room temperature, soak and obtain pretreatment fluid and meat through separation of solid and liquid after terminating
Desert cistanche pretreatment product；
Putting into be heated in distilled water seething with excitement by described saline cistanche pretreatment product and be incubated, insulation obtains through separation of solid and liquid after terminating
Carrying slag to saline cistanche Aqueous extracts and saline cistanche water, give up described saline cistanche Aqueous extracts, described saline cistanche water of selecting and remain carries slag；
Described saline cistanche water carries slag put into edible alcohol carries out soak at room temperature, soak and obtain saline cistanche through separation of solid and liquid after terminating
Alcohol extract and saline cistanche alcohol extracting slag, described saline cistanche alcohol extract is saline cistanche extract.
As preferably, described saline cistanche pretreatment product are put into the process carrying out again being incubated that is heated in distilled water seething with excitement and are specifically included:
First being put into by described saline cistanche pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out separation of solid and liquid, obtain the first saline cistanche Aqueous extracts and the first saline cistanche water carry slag；
Again described first saline cistanche water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out separation of solid and liquid after terminating, obtains the second saline cistanche Aqueous extracts and the second saline cistanche water carries slag；
Giving up described first saline cistanche Aqueous extracts and described second saline cistanche Aqueous extracts, described second saline cistanche water of selecting and remain carries slag；
Described second saline cistanche water is carried slag and puts into soak at room temperature in edible alcohol.
As preferably, described saline cistanche is Cistanche tubulosa dry product；The weight of Cistanche tubulosa fleshy stem dry product is 180g-220g,
The volume of the distilled water used of insulation for the first time is 3000mL-5000mL, and temperature retention time is 1.5h-2.5h for the first time, and second time is protected
The volume of temperature distilled water used is 3000mL-5000mL, and temperature retention time is 2.5h-3.5h for the second time.
As preferably, described saline cistanche pretreatment product are put into the process being heated to seething with excitement and be incubated in distilled water and are specifically included:
First being put into by described saline cistanche pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out separation of solid and liquid, obtain the first saline cistanche Aqueous extracts and the first saline cistanche water carry slag；
Again described first saline cistanche water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out separation of solid and liquid after terminating, obtains the second saline cistanche Aqueous extracts and the second saline cistanche water carries slag；
Described second saline cistanche water finally carries slag put into distilled water is heated to boiling, be first cooled to 50 DEG C-60 DEG C and carry out the again
Three insulations, third time insulation carries out separation of solid and liquid after terminating, obtains the 3rd saline cistanche Aqueous extracts and the 3rd saline cistanche water carries slag；
Give up described first saline cistanche Aqueous extracts, described second saline cistanche Aqueous extracts and described 3rd saline cistanche Aqueous extracts, institute of selecting and remain
State the 3rd saline cistanche water and carry slag；
Described 3rd saline cistanche water is carried slag and puts into soak at room temperature in edible alcohol.
As preferably, described saline cistanche is Cistanche tubulosa dry product；Cistanche tubulosa fleshy stem dry product soak at room temperature in distilled water
Time be 46h-50h.
As preferably, described saline cistanche is Cistanche tubulosa dry product；Described saline cistanche pretreatment product are first processed to thickness and are
Place into after the sheet saline cistanche pretreatment product of 0.5cm-2.5cm and distilled water is heated to boiling and is incubated.
As preferably, described saline cistanche is Cistanche tubulosa dry product；The Cistanche tubulosa fleshy stem dry product of every 180g-220g is frequent
Placing into after temperature distilled water immersion and be heated to boiling in the distilled water of 3000mL-5000mL and be incubated, temperature retention time is
4h-6h。
As preferably, described saline cistanche is Cistanche tubulosa dry product；The quality of Cistanche tubulosa fleshy stem dry product is 180g-220g,
The volume of described edible alcohol is 4500mL-5500mL, and in described edible alcohol, the volumn concentration of ethanol is 65%-75%,
It is 25 days-35 days that described saline cistanche water carries slag time of soak at room temperature in edible alcohol.
On the other hand, embodiments providing a kind of saline cistanche extract, described saline cistanche extract is by said method system
For obtaining.
As preferably, described saline cistanche extract is transparent brown liquid.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is directed to saline cistanche goods relatively big to cardiac stimulation, be particularly unsuitable for the technical problem of cardiovascular and cerebrovascular crowd, pass through
Confrontational technological design, improves the extraction process of saline cistanche extract, is first soaked in water by saline cistanche fleshy stem, then uses
The distilled water of boiling carries out water and carries, and gives up Aqueous extracts, the saline cistanche dregs of a decoction of selecting and remain, then is put into by the dregs of a decoction and carry out alcohol extracting in edible alcohol,
Obtain the saline cistanche extract of the present invention；Wherein, from reclaim saline cistanche filtrate as unlike the traditional handicraft of extract this
Bright the Aqueous extracts of saline cistanche is given up need not, and directly utilize the dregs of a decoction after water carries and carry out alcohol extracting again, use above-mentioned technique, pass through
Saline cistanche is soaked and water carries, the composition water such as large number of biological alkali and inorganic salts in saline cistanche can be carried and isolates, greatly reduce
Alkaloid in the saline cistanche dregs of a decoction and inorganic salt content, the most therefore reduce alkaloid and the inorganic salts ingredients intense stimulus to heart
And remain the organic compound ingredient in saline cistanche simultaneously；Therefore, the saline cistanche extract of the present invention is less to cardiac stimulation,
It is applicable to cardiovascular and cerebrovascular crowd, and saline cistanche adding proportion in its goods can be increased, and then it is bigger to give full play to it
Medical value, meets people's demand, promotes the industry development of saline cistanche.
Detailed description of the invention
By further illustrating the technological means and effect that the present invention taked by reaching predetermined goal of the invention, below preferably to implement
Example, to the foundation detailed description of the invention of the present patent application, technical scheme, feature and effect thereof, after describing in detail such as.Under state
Special characteristic, structure or feature in multiple embodiments in bright can be combined by any suitable form.
Embodiment 1
Choose Cistanche tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche tubulosa fleshy stem of 180g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche tubulosa fleshy stem out, obtain pre-
Treatment fluid and saline cistanche pretreatment product, now saline cistanche pretreatment product absorbed water swell quality increase, above-mentioned saline cistanche is located in advance
Reason product are cut into the sheet that thickness is 1cm, obtain sheet saline cistanche pretreatment product；Above-mentioned sheet saline cistanche pretreatment product are put into
The normal-temperature distilled water of 3000mL is heated to boiling, and constantly boiling 4 hours together, i.e. under fluidized state, is incubated 4 hours,
Insulation separates liquid and solid after terminating, and obtains saline cistanche Aqueous extracts and saline cistanche water carries slag, give up saline cistanche Aqueous extracts, select and remain
Saline cistanche water carries slag, uses manpower that above-mentioned saline cistanche water carries slag and dries, removes saline cistanche water and carry the excessive moisture on slag surface；Again
Above-mentioned saline cistanche water is carried slag put into volume be 4500mL alcoholic strength be 65% edible alcohol solution in (second in edible alcohol solution
The volumn concentration of alcohol is 65%) soak at room temperature takes out after 25 days, obtains saline cistanche alcohol extracting slag and transparent reddish brown through separation of solid and liquid
The saline cistanche alcohol extract of look, above-mentioned transparent henna saline cistanche alcohol extract is Cistanche tubulosa extract.
Embodiment 2
Choose Cistanche tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche tubulosa fleshy stem of 200g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche tubulosa fleshy stem out, obtain pre-
Treatment fluid and saline cistanche pretreatment product, now saline cistanche pretreatment product absorbed water swell quality increase, above-mentioned saline cistanche is located in advance
Reason product are cut into the sheet that thickness is 1cm, obtain sheet saline cistanche pretreatment product；Above-mentioned sheet saline cistanche pretreatment product are put into
The normal-temperature distilled water of 4000mL is heated to boiling, and constantly boiling 2 hours, i.e. insulation 2 for the first time under fluidized state together
Hour, insulation for the first time carries out separation of solid and liquid after terminating, and obtains the first saline cistanche Aqueous extracts and the first saline cistanche water carries slag, give up
First saline cistanche Aqueous extracts, the first saline cistanche water of selecting and remain carries slag, more above-mentioned first saline cistanche water is carried slag puts into the normal of 4000mL
First being heated to boiling in temperature distilled water, be cooled to 60 DEG C the most again, above-mentioned first saline cistanche water carries slag in the steaming that temperature is 60 DEG C
Soaking in distilled water 3 hours, i.e. second time insulation 3 hours, second time insulation carries out separation of solid and liquid after terminating, obtains the second meat desert
Rong's Aqueous extracts and the second saline cistanche water carry slag；Giving up above-mentioned second saline cistanche Aqueous extracts, above-mentioned second saline cistanche water of selecting and remain carries slag,
Use manpower that above-mentioned second saline cistanche water carries slag to dry, remove the second saline cistanche water and carry the excessive moisture on slag surface；Again by above-mentioned
Second saline cistanche water carries slag and puts into edible alcohol solution that 5000mL alcoholic strength the is 71% (volume hundred of ethanol in edible alcohol solution
Point content is 71%) in soak at room temperature take out after 30 days, obtain saline cistanche alcohol extracting slag and transparent henna meat desert through separation of solid and liquid
Rong's alcohol extract, above-mentioned transparent henna saline cistanche alcohol extract is Cistanche tubulosa extract.
Embodiment 3
Choose Cistanche tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche tubulosa fleshy stem of 200g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche tubulosa fleshy stem out, obtain pre-
Treatment fluid and saline cistanche pretreatment product, now saline cistanche pretreatment product absorbed water swell quality increase, above-mentioned saline cistanche is located in advance
Reason product are cut into the sheet that thickness is 1.5cm, obtain sheet saline cistanche pretreatment product；Above-mentioned sheet saline cistanche pretreatment product are put into
The normal-temperature distilled water of 4500mL is heated to boiling, and constantly boiling 2.5 hours, i.e. insulation for the first time under fluidized state together
2.5 hours, insulation for the first time carried out separation of solid and liquid after terminating, and obtains the first saline cistanche Aqueous extracts and the first saline cistanche water carries slag,
Giving up the first saline cistanche Aqueous extracts, the first saline cistanche water of selecting and remain carries slag, more above-mentioned first saline cistanche water is carried slag puts into 4500mL
Normal-temperature distilled water in first be heated to boiling, be cooled to 62 DEG C the most again, it is 62 DEG C that above-mentioned first saline cistanche water carries slag in temperature
Distilled water in soak 3 hours, i.e. second time insulation 3 hours, second time insulation terminate after carry out separation of solid and liquid, obtain second
Saline cistanche Aqueous extracts and the second saline cistanche water carry slag；Giving up above-mentioned second saline cistanche Aqueous extracts, above-mentioned second saline cistanche water of selecting and remain carries
Slag, uses manpower that above-mentioned second saline cistanche water carries slag and dries, remove the second saline cistanche water and carry the excessive moisture on slag surface；Again will
Above-mentioned second saline cistanche water carries slag and puts into edible alcohol solution that 5000mL alcoholic strength the is 70% (body of ethanol in edible alcohol solution
Long-pending percentage composition is 70%) in soak at room temperature take out after 32 days, obtain saline cistanche alcohol extracting slag and transparent henna through separation of solid and liquid
Saline cistanche alcohol extract, above-mentioned transparent henna saline cistanche alcohol extract is Cistanche tubulosa extract.
Embodiment 4
Choose Cistanche tubulosa fleshy stem, remove its surface sandy soil and clean up, the Cistanche tubulosa fleshy stem of 220g is put
Enter in the normal-temperature distilled water of about 3000mL and soak, after soaking 48 hours, pull Cistanche tubulosa fleshy stem out, obtain pre-
Treatment fluid and saline cistanche pretreatment product, now saline cistanche pretreatment product absorbed water swell quality increase, above-mentioned saline cistanche is located in advance
Reason product are cut into the sheet that thickness is 2cm, obtain sheet saline cistanche pretreatment product；Above-mentioned sheet saline cistanche pretreatment product are put into
The normal-temperature distilled water of 5000mL is heated to boiling, and constantly boiling 2 hours, i.e. insulation 2 for the first time under fluidized state together
Hour, insulation for the first time carries out separation of solid and liquid after terminating, and obtains the first saline cistanche Aqueous extracts and the first saline cistanche water carries slag, give up
First saline cistanche Aqueous extracts, the first saline cistanche water of selecting and remain carries slag, more above-mentioned first saline cistanche water is carried slag puts into the normal of 5000mL
First being heated to boiling in temperature distilled water, be cooled to 65 DEG C the most again, above-mentioned first saline cistanche water carries slag in the steaming that temperature is 65 DEG C
Soaking in distilled water 2 hours, i.e. second time insulation 2 hours, second time insulation carries out separation of solid and liquid after terminating, obtains the second meat desert
Rong's Aqueous extracts and the second saline cistanche water carry slag, give up above-mentioned second saline cistanche Aqueous extracts, and above-mentioned second saline cistanche water of selecting and remain carries slag；
Above-mentioned second saline cistanche water carries slag again put into the normal-temperature distilled water of 5000mL is first heated to boiling, is cooled to 60 DEG C the most again,
Above-mentioned second saline cistanche water carries slag and soaks in the distilled water that temperature is 60 DEG C 2 hours, i.e. third time insulation 2 hours, for the third time
Insulation carries out separation of solid and liquid after terminating, and obtains the 3rd saline cistanche Aqueous extracts and the 3rd saline cistanche water carries slag；Use manpower by above-mentioned the
Three saline cistanche water carry slag and dry, and remove the 3rd saline cistanche water and carry the excessive moisture on slag surface；Again above-mentioned 3rd saline cistanche water is carried slag
Put in the edible alcohol solution (in edible alcohol solution, the volumn concentration of ethanol is 75%) that 5500mL alcoholic strength is 75%
Soak at room temperature took out after 35 days, obtained saline cistanche alcohol extracting slag and transparent henna saline cistanche alcohol extract through separation of solid and liquid, above-mentioned
Transparent henna saline cistanche alcohol extract is Cistanche tubulosa extract.
Embodiment 5
Cistanche tubulosa extract embodiment 1-embodiment 4 prepared is diluted to the liquid that alcoholic strength is 40 degree, and (ethanol is at liquid
Volumn concentration in body is 40%), obtain No. 1 liquid, No. 2 liquid, No. 3 liquid and No. 4 liquid, ask 20 one-tenth
Year, the male sex took aforesaid liquid before sleep, 20 male sex is divided into four groups, often organizes 5 people, and first group of male sex takes 100mL
No. 1 liquid, second group of male sex takes No. 2 liquid of 100mL, and the 3rd group of male sex takes No. 3 liquid of 100mL, the 4th
The group male sex takes No. 4 liquid of 100mL, within second day, recognizes the physiology impression of these four groups of people, all represents that sleep quality is preferable,
Body and mind is without sense of discomfort, and second day hale and hearty, and state is preferable.
Comparative example 1
200g main flower herba cistanches is soaked in the ethanol solution that 5000mL alcoholic strength is 71%, takes out after soaking 30 days,
To Cistanche tubulosa extract, then this extract is diluted to liquid (the ethanol volume hundred in a liquid that alcoholic strength is 40 degree
Dividing content is 40%), obtain No. 5 liquid；
Comparative example 2
From a kind of saline cistanche medicinal liquor of market buying, processing method is: saline cistanche drying and crushing sieved, and adds filter residue weight
6-8 times of volume pure water, ultrasonic extraction 1 hour, after filtration, filter residue is carried out second extraction, the Extraction solvent of twice extraction, carry
Take the time all identical with extraction process for the first time with extracting method, merge twice filtrate, concentrate the filtrate to the 1/5 of original volume,
Obtain the aqueous extract of saline cistanche；Filter residue is extracted 2 times with the EtOH Sonicate of 70%, each 1 hour, refilters, merge filter
Liquid is also concentrated into the 1/5 of original volume, obtains the alcohol extract of saline cistanche；By aqueous extract and the alcohol of saline cistanche of above-mentioned saline cistanche
Extract merges, liquid liquid (the ethanol volumn concentration in a liquid being diluted to alcoholic strength 40 degree after merging
It is 40%), obtain No. 6 liquid.
Comparative example 3
No. 5 and No. 6 liquid comparative example 1-comparative example 3 prepared, ask 20 adult males same in embodiment 5 to be tried out
Personnel take above-mentioned dilution before sleep, and first group of male sex takes No. 5 liquid of 100mL, and second group of male sex takes 100mL
No. 6 liquid, within second day, recognize the physiology impression of these three groups of people, all represent that head makes a sound in a grand fashion when just starting, dizzy dizzy heavy
Heavy, as flood tide, head two vascellum laterale is the most swollen, and and then heart touches and beats rapidly, extremely feels bad, and night falls asleep some
More have heart to accelerate suddenly to beat after hour, make people wake up with a start from sleep state, heart again bang bang make a sound, after general ten a few minutes,
Slightly return calmness, again fall asleep, the most twice or thrice after tranquil just now fall asleep.
Commercially available or the self-control saline cistanche goods that above-mentioned comparative example 1 and comparative example 2 provide, all can be by human consumption, and taking dose is equal
In the range of safety using amount, it is mainly used in improving the health.Therefore, the present inventor is by comparative example 1 and the saline cistanche of comparative example 2
Goods allow person on probation take, and by embodiment 5 and the personal experiences of the person on probation of comparative example 3, prepared by the present invention
Saline cistanche extract sense of discomfort is less, the most non-stimulated to heart, does not affect ortho, edible rear hale and hearty；And contrast
Human heart is stimulated relatively big by the saline cistanche goods of example 1 and comparative example 2 preparation after eating, have a strong impact on ortho, after eating
Mood is restless.
Saline cistanche is powerful well-known with function for tonifying kidney, Compendium of Material Medica record: time treasure say this thing mend and the highest, therefore have from
Appearance number.Calmly, gentle looks；But this book is recorded with a piece the most simultaneously: good Gu says gate of vitality fire deficiency person mutually, mends it with this,
Be kidney channel blood system medicine also.All desert cistanches that takes, to control kidney, must hamper the heart (modern explanation: harm the function of heart).Ancients early have research,
Take saline cistanche kidney tonifying can but be unfavorable for human heart simultaneously；For another example containing saline cistanche in certain whole nation famous brand name health liquor, its note
This wine is not suitable for Patients with Cardiovascular/Cerebrovascular Diseases just to have one to show in meaning item；Understand, the most in ancient times or modern times, people
All recognize that saline cistanche kidney tonifying can be unfavorable for human heart simultaneously, and in the preparation technology of modern health wine product, all fail solution make
Saline cistanche can weaken again its technical problem stimulating human heart while reaching kidney tonifying.But, saline cistanche has activation kidney
Upper gland, the function of release cortin, its mechanism of action is the function strengthening Hypothalamus-pituitary, and saline cistanche can make animal red carefully
The activity of born of the same parents' superoxide dismutase (SOD) is remarkably reinforced, and can repair heart, liver damage cell, and brain tissue can be delayed to decline
Old degeneration, has protection liver and promotes the effect of physical efficiency recovery, can obviously improve myocardial infarction phenomenon, improving in cardiac muscular tissue
Creatine phosphokinase vigor, has protection ischemic myocardium effect, can promote the recovery of hemopoietic function of bone marrow；In sum, meat desert
Rong, in addition to having kidney-replenishing, benefiting essence-blood, the tradition such as relax bowel effect, also has anti-oxidant, radioresistance, improves memory
Deng effect, to the most protected effects such as the heart, brain, lung, liver, kidney and immune systems.And for Patients with Cardiovascular/Cerebrovascular Diseases, meat
Above-mentioned effect in desert cistanche is conducive to treating cardiovascular and cerebrovascular disease, but because the defect of prior art also cannot overcome saline cistanche to be unfavorable for
The technical problem of human heart, causes saline cistanche originally to can be used for helping treatment cardiovascular and cerebrovascular disease, but makes because of the defect of prior art
Saline cistanche goods stimulate human heart, and make Patients with Cardiovascular/Cerebrovascular Diseases cannot take saline cistanche goods, and then make it lose one
The approach for the treatment of cardiovascular and cerebrovascular disease, the most unfortunately.
The present invention is directed to limit due to saline cistanche goods cardiac stimulus Patients with Cardiovascular/Cerebrovascular Diseases can not use saline cistanche goods with
For treating the technical problem of its disease, by confrontational technological design, the extraction process of saline cistanche extract is improved, first
Saline cistanche fleshy stem is soaked in water, then carries out water carry with the distilled water of boiling, give up Aqueous extracts, the saline cistanche dregs of a decoction of selecting and remain, then
The dregs of a decoction are put into edible alcohol carries out alcohol extracting, obtain the saline cistanche extract of the present invention；Wherein, make with recovery saline cistanche filtrate
The present invention unlike the traditional handicraft of extract the Aqueous extracts of saline cistanche is given up need not, and directly utilize the dregs of a decoction after water carries
Carry out alcohol extracting again, use above-mentioned technique, by saline cistanche immersion and water are carried, can be by large number of biological alkali and inorganic salts in saline cistanche
Carry in composition water and isolate, greatly reduce the alkaloid in the saline cistanche dregs of a decoction and inorganic salt content, also reduce alkaloid and
Inorganic salts ingredients is to the intense stimulus of heart and remains the organic compound ingredient in saline cistanche simultaneously；Therefore, the meat of the present invention
Desert cistanche extract is less to cardiac stimulation, is applicable to cardiovascular and cerebrovascular crowd, and can increase saline cistanche interpolation in its goods
Ratio；Such as, owing to fearing the saline cistanche intense stimulus to heart, generally, in 5000mL71 degree medicinal liquor, saline cistanche is former
Material safety using amount is 30g-50g, and can be containing the saline cistanche raw material of 180-220g in the edible alcohol of 5000mL of the present invention, phase
Under Bi, by the process modification of the present invention, in the edible alcohol of same volume, its safe handling amount is greatly improved；Due to meat desert
The raising of Rong's safe handling amount, making to be suitable for crowd's scope increases, and has also given full play to its bigger medical value, has better met
The demand of people, especially meets the demand of Patients with Cardiovascular/Cerebrovascular Diseases, helps treatment cardiovascular and cerebrovascular disease for which increasing one
Approach, the most preferably promote the development of saline cistanche industry.
The preparation method of a kind of saline cistanche extract that the embodiment of the present invention provides, wherein puts into distillation by saline cistanche fleshy stem dry product
Water carries out soak at room temperature, in order to biltong desert cistanche is bubbled open, and remove be mixed in various surface impurity therein, its water consumption without
Particular requirement, as long as fully bubbling open saline cistanche fleshy stem dry product.
The product that pre-processed by saline cistanche in embodiment of the present invention method are put into normal-temperature distilled water and are heated to the mistake being incubated again of seething with excitement together
Journey, can be carried out once；Such as, the product that pre-processed by saline cistanche are put into after normal-temperature distilled water is heated to boiling together, and constantly boiling
4-6 hour, obtain saline cistanche water and carry slag；This technique can meet the alkaloid in saline cistanche and inorganic salts material water are carried and divided
The requirement separated out.
The product that pre-processed by saline cistanche in embodiment of the present invention method are put into normal-temperature distilled water and are heated to the mistake being incubated again of seething with excitement together
Journey, can be carried out twice；Such as, the product that pre-processed by saline cistanche are put into after normal-temperature distilled water is heated to boiling together, and carry out first
Secondary insulation, temperature retention time is 1.5h-2.5h hour, obtains the first saline cistanche water and carries slag, the first saline cistanche water is carried slag and puts into often
After temperature distilled water is heated to boiling together, then it is cooled to 55 DEG C-65 DEG C, carries out second time at such a temperature and be incubated, during insulation
Between be 2.5h-3.5h hour, obtain the second saline cistanche water and carry slag；Wherein, temperature retention time preferably 2 hours for the first time, for the second time
Temperature retention time preferably 3 hours；Use above-mentioned twice extraction process by water, can be fully by the alkaloid in saline cistanche and inorganic salts material
Water carries and isolates；Wherein, the purpose of second time cooling is major part alkaloid and inorganic after boiled water puies forward process through first time
Salts substances is proposed by water, then carries out second time water and carry, if also using boiled water to carry, and may also can be by a small amount of organic substance
Water proposes, and in order to retain the organic substance in saline cistanche as far as possible, in second time water carries, water temperature is down to 55 DEG C-65 DEG C,
At a temperature of Gai, i.e. can reach abundant water and carry alkaloid remaining in saline cistanche and inorganic salts material, it is possible to retain saline cistanche as possible
In organic substance.
The product that pre-processed by saline cistanche in embodiment of the present invention method are put into normal-temperature distilled water and are heated to the mistake being incubated again of seething with excitement together
Journey, also can be carried out three times；After the insulation of above-mentioned second time terminates, the second saline cistanche water is carried slag and puts in distilled water and heat together
To seething with excitement and being cooled to 50 DEG C-60 DEG C, be incubated at such a temperature, separated after obtain the 3rd saline cistanche water and carry slag；Pass through
Three water carries and overwhelming majority alkaloids and inorganic salts material water can be proposed and filter out by the technique progressively lowered the temperature, greatly reduces
Water carries alkaloid and the content of inorganic salts material in slag, also remains the organic substance in saline cistanche, in order to saline cistanche is filled
Its medical value is waved in distribution.
Above-mentioned twice water puies forward process and three water put forward process, and the water of even more than three times puies forward process all can meet technology requirement, but examines
Consider to Cost Problems, it is preferred to use twice and the water lowered the temperature step by step put forward process and can preferably meet the requirement of the present invention.
Being soaked 48 hours through normal-temperature water by 180g-220g saline cistanche fleshy stem dry product in embodiment of the present invention method, places into
The distilled water of 3000mL-5000mL is heated to boiling and carries out being incubated for the first time, in said process, and saline cistanche fleshy stem dry product weight
Amount and the distilled water soaked have certain proportionate relationship, it is desirable to alkaloid and inorganic salts material in dry product can not be at distilled water
In reach saturated, this saturation degree can by specialty detection analytical equipment obtain, if distilled water is very few, the most saturated, in saline cistanche
Alkaloid and inorganic salts material fully can not be carried by water and filter out, and affect the medicinal effects of later stage extract, to cardiac stimulation
Degree may also can exist, and therefore, the present inventor obtains using above-mentioned adding proportion by great many of experiments and data analysis, not only
Saving the water yield can avoid again the alkaloid in distilled water and inorganic salts material to reach saturated, dry product and steaming in insulating process for the second time
The ratio of distilled water is identical with first time.
In the method for the embodiment of the present invention, saline cistanche water is carried slag and puts into soak at room temperature 25-35 days in edible alcohol, wherein, food
Being 65%-75% with the volumn concentration of ethanol in alcohol, the present inventor selects the alcohol concentration of above-mentioned 65%-75%, is because
The organic principle in saline cistanche dissolution rate in the ethanol solution that concentration is 65%-75% is maximum, in above-mentioned concentration range, and meat
The main component the working health i.e. organic compound that desert cistanche contains can be proposed by alcohol fully in a large number from saline cistanche,
To saline cistanche alcohol extract in organic principle i.e. medicinal ingredient more, medical value is maximum；The present inventor is divided by great many of experiments
Analysis, saline cistanche water preferably carrying slag and is soaked in the volumn concentration of ethanol is the saline cistanche obtained time in the edible alcohol of 71%
Organic matter content in alcohol extract is maximum, and this content can be obtained by specialty detection analytical equipment.
The method of the embodiment of the present invention is applicable to polytype saline cistanche, due to the local Cistanche tubulosa yield of the present inventor relatively
The most more typically, the present inventor only carries out the extraction process of the present invention with Cistanche tubulosa for representing raw material.
Cistanche tubulosa in the embodiment of the present invention can be the most freezing, or dry, or fresh, it is contemplated that fresh
Saline cistanche be difficult to preserve and cost is relatively big, present invention preferably employs the Cistanche tubulosa dried and carry out technique extraction.
The saline cistanche extract prepared by the method for the present invention is the most non-stimulated to human heart, and the safety that improve saline cistanche makes
Consumption, has given full play to the medical value of saline cistanche, extends the application crowd of saline cistanche goods, promotes the industry of saline cistanche
Development, has driven the economic development in the saline cistanche place of production.
The detailed description of the invention being only the present invention disclosed above, but protection scope of the present invention is not limited thereto, any familiar
Those skilled in the art, in the technical scope that the invention discloses, can readily occur in change or replace, should contain at this
Within the protection domain of invention.Therefore, protection scope of the present invention should be as the criterion with above-mentioned scope of the claims.
Claims (10)
1. the preparation method of a saline cistanche extract, it is characterised in that comprise the following steps:
Saline cistanche fleshy stem is put in distilled water and carry out soak at room temperature, soak and obtain pretreatment fluid and meat through separation of solid and liquid after terminating
Desert cistanche pretreatment product；
Putting into be heated in distilled water seething with excitement by described saline cistanche pretreatment product and be incubated, insulation obtains through separation of solid and liquid after terminating
Carrying slag to saline cistanche Aqueous extracts and saline cistanche water, give up described saline cistanche Aqueous extracts, described saline cistanche water of selecting and remain carries slag；
Described saline cistanche water carries slag put into edible alcohol carries out soak at room temperature, soak and obtain saline cistanche through separation of solid and liquid after terminating
Alcohol extract and saline cistanche alcohol extracting slag, described saline cistanche alcohol extract is saline cistanche extract.
The preparation method of a kind of saline cistanche extract the most according to claim 1, it is characterised in that described saline cistanche is pre-
Item for disposal is put into the process carrying out again being incubated that is heated in distilled water seething with excitement and is specifically included:
First being put into by described saline cistanche pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out separation of solid and liquid, obtain the first saline cistanche Aqueous extracts and the first saline cistanche water carry slag；
Again described first saline cistanche water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out separation of solid and liquid after terminating, obtains the second saline cistanche Aqueous extracts and the second saline cistanche water carries slag；
Giving up described first saline cistanche Aqueous extracts and described second saline cistanche Aqueous extracts, described second saline cistanche water of selecting and remain carries slag；
Described second saline cistanche water is carried slag and puts into soak at room temperature in edible alcohol.
The preparation method of a kind of saline cistanche extract the most according to claim 2, it is characterised in that described saline cistanche is
Cistanche tubulosa dry product；The weight of Cistanche tubulosa fleshy stem dry product is 180g-220g, the body of the distilled water used of insulation for the first time
Amassing as 3000mL-5000mL, temperature retention time is 1.5h-2.5h for the first time, and the volume of second time insulation distilled water used is
3000mL-5000mL, temperature retention time is 2.5h-3.5h for the second time.
The preparation method of a kind of saline cistanche extract the most according to claim 1, it is characterised in that described saline cistanche is pre-
Item for disposal is put into the process being heated to seething with excitement and be incubated in distilled water and is specifically included:
First being put into by described saline cistanche pretreatment product and be heated to boiling in distilled water and carry out being incubated for the first time, insulation for the first time terminates
After carry out separation of solid and liquid, obtain the first saline cistanche Aqueous extracts and the first saline cistanche water carry slag；
Again described first saline cistanche water is carried slag put into distilled water is heated to boiling, be first cooled to 55 DEG C-65 DEG C and carry out second again
Secondary insulation, second time insulation carries out separation of solid and liquid after terminating, obtains the second saline cistanche Aqueous extracts and the second saline cistanche water carries slag；
Described second saline cistanche water finally carries slag put into distilled water is heated to boiling, be first cooled to 50 DEG C-60 DEG C and carry out the again
Three insulations, third time insulation carries out separation of solid and liquid after terminating, obtains the 3rd saline cistanche Aqueous extracts and the 3rd saline cistanche water carries slag；
Give up described first saline cistanche Aqueous extracts, described second saline cistanche Aqueous extracts and described 3rd saline cistanche Aqueous extracts, institute of selecting and remain
State the 3rd saline cistanche water and carry slag；
Described 3rd saline cistanche water is carried slag and puts into soak at room temperature in edible alcohol.
The preparation method of a kind of saline cistanche extract the most according to claim 1, it is characterised in that described saline cistanche is
Cistanche tubulosa dry product；Cistanche tubulosa fleshy stem dry product time of soak at room temperature in distilled water is 46h-50h.
The preparation method of a kind of saline cistanche extract the most according to claim 1, it is characterised in that described saline cistanche is
Cistanche tubulosa dry product；Described saline cistanche pretreatment product are first processed to the sheet saline cistanche pretreatment that thickness is 0.5cm-2.5cm
Place into after product in distilled water and be heated to boiling and be incubated.
The preparation method of a kind of saline cistanche extract the most according to claim 1, it is characterised in that described saline cistanche is
Cistanche tubulosa dry product；The Cistanche tubulosa fleshy stem dry product of every 180g-220g places into after normal temperature distilled water immersion
Being heated to boiling in the distilled water of 3000mL-5000mL and be incubated, temperature retention time is 4h-6h.
The preparation method of a kind of saline cistanche extract the most according to claim 1, it is characterised in that described saline cistanche is
Cistanche tubulosa dry product；The quality of Cistanche tubulosa fleshy stem dry product is 180g-220g, and the volume of described edible alcohol is
4500mL-5500mL, in described edible alcohol, the volumn concentration of ethanol is 65%-75%, and described saline cistanche water carries slag edible
In alcohol, the time of soak at room temperature is 25 days-35 days.
9. a saline cistanche extract, it is characterised in that described saline cistanche extract is by described in any one of claim 1-8
Method prepares.
A kind of saline cistanche extract the most according to claim 9, it is characterised in that described saline cistanche extract is transparent
Brown liquid.
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Cited By (1)
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| CN108834713A (en) * | 2018-06-28 | 2018-11-20 | 普定县真源农业开发有限公司 | A method of mitigating apple high temperature injury |
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