CN105998643A - Compound traditional Chinese medicinal spray for preventing and treating mink scab and preparation method of compound traditional Chinese medicinal spray - Google Patents

Abstract

The invention discloses a compound traditional Chinese medicinal spray for treating mink scab and a preparation method of the compound traditional Chinese medicinal spray. The compound traditional Chinese medicinal spray is prepared from the following various components in parts by weight: 10-20 parts of bark of Chinese catalpa, 4-8 parts of tea oil cakes, 5-10 parts of lard, 50-80 parts of root of spinach beet, 10-18 parts of longleaf bastardtoadflax herb, 20-40 parts of fruits of balsamper, 10-20 parts of patience dock root, 5-11 parts of radix ampelopsis, 10-30 parts of oriental stephania root, 10-20 parts of lignum santali albi, 10-30 parts of radix chloranthi serrati, 10-20 parts of semen phaseoli, 8-18 parts of leaves of sessileflower acanthopanax, 6-12 parts of tengyuch euonymus bark, 20-40 parts of Japanese thistle herb, 5-9 parts of pangolin scales, 3-5 parts of elephant hide, 6-12 parts of liquorice root, 6-10 parts of jojoba seed oil and 6-12 parts of propolis. The compound traditional Chinese medicinal spray disclosed by the invention, which is prepared from pure traditional Chinese medicines, is safe and free from toxic sides; and the compound traditional Chinese medicinal spray can replace dipterex like drugs to effectively treat the skin scab; therefore, the compound traditional Chinese medicinal spray is conducive to the improvement of farmers' economic benefits.

Description

The Chinese medicine of preventing and treating mink mange and scab is combined spray and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preventing and treating mink mange and scab and be combined spray, The invention still further relates to this Chinese medicine and be combined the preparation method of spray.

Background technology

Standard mink skin is the fur coat of a kind of preciousness, and kind color is varied, expensive, has " king of fur coat " Laudatory title.In terms of the quality and value of standard mink skin, its utilization rate is also above the big capillary skin such as Vulpes, raccoon fur, especially It is that domestic market potentiality are the biggest.Standard mink skin is the shortest with its lint, bright luxurious and famous, be make clothes, The primary raw material skin of collar, medicated cap, cuff and decorations mouth, utilizes face relatively wide, and demand is the biggest.And Vulpes, Nyctereutes procyonoides The big capillary skin such as skin, owing to lint relatively standard mink skin is the longest, magnificent not as good as standard mink skin, domestic market is not suitable for system Overcoat, and it is only suitable for making the ornaments such as collar, cuff, tippet, therefore utilization rate is low compared with standard mink skin.Thus may be used Seeing, the development prospect of the little capillary skin animal based on mink is better than the big capillary skin animal such as Vulpes, Nyctereutes procyonoides.Send out The economic worth that exhibition mink produces, outside defeathering skin, other by-product values are the most considerable.Mink meat flavour is beautiful Good to eat, nutritious, high containing protein, heat is big.According to surveying and determination, containing dry 38.4% in mink meat, its Middle protein 18%, fat 12%.Every 100g meat heat content is 3320J, and current mink meat becomes a kind of tool There is the game delicacies of flavour.

Mink mange and scab is a kind of epizoa property skin caused by the itch mite or acaricide parasitizing mink body surface Disease, is commonly called as leprosy, is a kind of parasitic dermatosis of mink, Vulpes, Nyctereutes procyonoides, and contagious infection, winter-spring season is easy Multiple.This disease infectiousness is very strong, and to be infected by contact with, the lighter makes animal become thin, and severe one causes death. Acaricide and the whole growth course of itch mite all complete on animal body.Acaricide digs chisel tunnel at host's epidermis, with skin Skin tissue, cell and lymph fluid are food, and grow and breeding at Intradermal.Itch mite then parasitizes skin surface, To suck skin transudate for food.

Clinical symptoms: itch mite takes place mostly in external auditory meatus, can cause otitis externa, and exudate is dried formation Yellow crust, fills up auditory meatus such as paper roll sample.Sick beast ear is sagging, constantly shakes the head and uses foot ear scratch piece, it is also possible to It is extended down to sieve skeleton and brain, sick beast performance torticollis, finally twitch and dead.

Acaricide is typically fallen ill by around mouth nose and claw portion, very itches, and sick beast constantly bites foot or use foot with mouth Scratch mouth, nose etc., when seriously itching before and after foot grab ground, pathological changes portion occurs that canescence sticks with paste block.Eyelet, nose Occurring scurf and blood crusts, lip swelling bottom beam, front foot plate surface and the rear foot, impact is searched for food, and sick beast disappears rapidly Thin, until dead.

At present, the method for the treatment of mink mange and scab mainly by affected part and being cut off by hair at 3-4cm about, Thoroughly scrub with temperature suds, remove hard crust and dirt, scrub with 20% lysol, dry rear coating, Such as dichlorvos, metrifonate, the spirit of leprosy demodicid mite etc., forming residual hazard in may penetrate into skin and flesh, therapeutic effect is the most undesirable, Cure rate is low.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine preventing and treating mink mange and scab and be combined spray and preparation method thereof, The Chinese medicine of the present invention is combined spray and uses pure Chinese medicine to make, and safety has no side effect, and can replace metrifonate class medicine, Effectively treatment mink mange and scab, can go out with metabolism after penetrating in skin and flesh, is conducive to improving the warp of raiser Ji benefit.

To achieve these goals, present invention provide the technical scheme that

A kind of Chinese medicine treating mink mange and scab is combined spray, is made up of each component of following parts by weight: Chinese catalpa Rhizoma Euonymus 10-20 part, Oleum Camelliae cake 4-8 part, Adeps sus domestica 5-10 part, dish 50-80 part, Herba Thesii Longifolii 10-18 Part, Fructus Momordicae charantiae 20-40 part, Radix Rumicis Patientiae 10-20 part, Radix Ampelopsis 5-11 part, Rhizoma Polygonati Cirrhifolii 10-30 part, Symplocoris Paniculatae 10-20 Part, Radix Chloranthi Serrati 10-30 part, Semen Phaseoli 10-20 part, Folium Acanthopanacis Radicis 8-18 part, Rhizoma Euonymus 6-12 part, Radix Cirsii Japonici 20-40 Part, Squama Manis 5-9 part, Corium elephatis 3-5 part, Radix Glycyrrhizae 6-12 part, Jojoba oil 6-10 part, propolis 6-12 part.

Further, a kind of Chinese medicine treating mink mange and scab is combined spray, by each group of following parts by weight Point make: Cortex catalpae ovatae radicis 10 parts, Oleum Camelliae cake 4 parts, Adeps sus domestica 5 parts, dish 50 parts, Herba Thesii Longifolii 10 parts, 20 parts of Fructus Momordicae charantiae, Radix Rumicis Patientiae 10 parts, Radix Ampelopsis 5 parts, Rhizoma Polygonati Cirrhifolii 10 parts, Symplocoris Paniculatae 10 parts, Radix Chloranthi Serrati 10 parts, Semen Phaseoli 10 parts, Folium Acanthopanacis Radicis 8 parts, Rhizoma Euonymus 6 parts, Radix Cirsii Japonici 20 parts, Squama Manis 5 parts, Corium elephatis 3 parts, 6 parts of Radix Glycyrrhizae, Jojoba oil 6 parts, propolis 6 parts.

Further, a kind of Chinese medicine treating mink mange and scab is combined spray, by each group of following parts by weight Divide and make: Cortex catalpae ovatae radicis 20 parts, Oleum Camelliae cake 8 parts, Adeps sus domestica 10 parts, dish 80 parts, Herba Thesii Longifolii 18 Part, 40 parts of Fructus Momordicae charantiae, Radix Rumicis Patientiae 20 parts, Radix Ampelopsis 11 parts, Rhizoma Polygonati Cirrhifolii 30 parts, Symplocoris Paniculatae 20 parts, Radix Chloranthi Serrati 30 Part, Semen Phaseoli 20 parts, Folium Acanthopanacis Radicis 18 parts, Rhizoma Euonymus 12 parts, Radix Cirsii Japonici 40 parts, Squama Manis 9 parts, Corium elephatis 5 Part, 12 parts of Radix Glycyrrhizae, Jojoba oil 10 parts, propolis 12 parts.

Further, a kind of Chinese medicine treating mink mange and scab is combined spray, by each group of following parts by weight Point make: Cortex catalpae ovatae radicis 15 parts, Oleum Camelliae cake 6 parts, Adeps sus domestica 8 parts, dish 65 parts, Herba Thesii Longifolii 14 parts, 30 parts of Fructus Momordicae charantiae, Radix Rumicis Patientiae 15 parts, Radix Ampelopsis 8 parts, Rhizoma Polygonati Cirrhifolii 20 parts, Symplocoris Paniculatae 15 parts, Radix Chloranthi Serrati 20 parts, Semen Phaseoli 15 parts, Folium Acanthopanacis Radicis 13 parts, Rhizoma Euonymus 9 parts, Radix Cirsii Japonici 30 parts, Squama Manis 7 parts, Corium elephatis 4 parts, 9 parts of Radix Glycyrrhizae, Jojoba oil 8 parts, propolis 9 parts.

In inventive formulation, the performance of each raw material is as follows:

Cortex catalpae ovatae radicis: for root bark or the phloem of bark of Bignoniaceae plant Chinese catalpa.Hardship, cold." Changsha medicine solution ": " enter foot-shaoyang gallbladder, the stomach channel of foot-Yang-ming." heat clearing away, removing toxic substances, parasite killing.Control seasonal disease to generate heat, jaundice, regurgitation, Skin pruritus, skin ulcer scabies；Oleum Camelliae cake: medical material Ji Yuan is the slag that plant of theaceae Seed of Camellia oleifera squeezes after removing fatty oil Dregs.Pungent, bitter, puckery, flat, slightly poisonous.Return spleen, stomach, large intestine channel.Dampness is detoxified, and parasite killing goes to amass, disappears Swollen pain relieving.Main eczema sufferings, abdominal pain due to worm stagnation, traumatic injury wound is swollen；Adeps sus domestica: for the fatty oil of porcine animals pig. Sweet, cool.Taste liquid is moisturized, heat-clearing and toxic substances removing.For asthenia weakness and emaciation, cough, jaundice, constipation, chapped skin, Skin infection, burn and scald；Dish: medicinal part is that multitude plants the stem of plant dish, leaf.Sweet, cool." Yunnan South book on Chinese herbal medicine ": " enter Yangming Channel." heat-clearing and toxic substances removing, clots absorbing stops blooding.Control measles and thoroughly send out unhappy, pyretic toxicity dysentery, Amenorrhea stranguria with turbid discharge, carbuncle is traumaticd fracture；Herba Thesii Longifolii: medicinal part is that Santalaceae plant comes into leaves Herba Thesii or the Western Regions hundred stamen The herb of grass.Pungent, micro-hardship, cool in nature.Return lung, liver, spleen channel.Expelling wind and clearing away heat, spasmolytic.Cure cold, in Summer-heat, infantile pneumonia, cough, infantile convulsion.Herba Thesii Longifolii element II in Herba Thesii Longifolii is to staphylococcus aureus, mucositis Coccus, Bacillus typhi, Bacillus proteus, dysentery bacterium all have inhibitory action；Succinic acid to Candida albicans without Inhibitory action.Herba Thesii Longifolii element I has inhibitory action to staphylococcus aureus, micrococcus catarrhalis, dysentery bacterium； Fructus Momordicae charantiae: Cucurbitaceae Momordica plant Fructus Momordicae charantiae, is used as medicine with melon, root, rattan and leaf.Hardship, cool.Heat-clearing and toxic substances removing. Generate heat for heatstroke, toothache, enteritis, dysentery, have blood in stool；Miliaria, furuncle furuncle and phyma are controlled in external；Radix Rumicis Patientiae: General designation for Polygonaceae Rumex various plants.In addition to curled dock, Radix Rumicis Japonici and rumex dentatus, still there is BATIAN acid Mould, Rumex chalepensis and narrow leaf Radix rumicis acetosae, be all used as medicine with root.Bitter, sour, cold.Cooling blood for hemostasis, heat-clearing and toxic substances removing, Parasite killing.For dysfunctional uterine hemorrhage, spitting blood, spitting of blood, epistaxis, gingival hemorrhage, tail, duodenum go out Blood, has blood in stool, purpura, constipation, edema；Scabies, furuncle, seborrheic dermatitis are controlled in external；Radix Ampelopsis: this product Dried root for vitaceae Radix Ampelopsis.Hardship, is slightly cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation. For carbuncle carbuncle on the back, furuncle, scrofula, burn due to hot liquid or fire；Rhizoma Polygonati Cirrhifolii: medicinal part is liliaceous plant leaf roll The rhizome of Rhizoma Polygonati.Gan Xin is flat.Nourishing lung-YIN, invigorating the spleen and benefiting QI, hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease Cough, dizzy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, and spitted blood, and epistaxis, wound goes out Blood, laryngopharynx swelling and pain, skin ulcer swells, scrofula；Symplocoris Paniculatae: for Symplocaceae Symplocoris Paniculatae, be used as medicine with Herb.Acrid in the mouth, warm in nature, Nontoxic.Heat-clearing and toxic substances removing, regulating QI eliminating stagnation, dispelling wind for relieving itching.Main mastitis, lymphadenitis, acute appendicitis, furuncle, Hernia, urticaria, skin pruritus；Radix Chloranthi Serrati: for gold Li Lanke gold chestnut epidendrum Radix Chloranthi Serrati, with root or herb It is used as medicine.Pungent, warm.Poisonous.Relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping, subduing swelling and detoxicating.For traumatic injury, rheumatism Lumbago and skelalgia, furuncle swelling toxin, venom；Semen Phaseoli: this product is being dried of leguminous plant Semen Phaseoli or Semen Phaseoli Mature seed.Sweet, sour, flat.GUIXIN, small intestine meridian.Inducing diuresis to remove edema, removing toxic substances and promoting pus discharge.For edema distension, Tinea pedis limb swells, jaundice dark coloured urine, beriberoid pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess；Folium Acanthopanacis Radicis: plant for Araliaceae The leaf of thing slender acanthopanax, Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem. or Radix Et Caulis Acanthopanacis Senticosi etc..Acrid in the mouth, property is put down.Dissipate wind dehumidifying, promoting blood circulation and stopping pain, heat clearing away Removing toxic substances.Main skin rheumatism, treating swelling and pain by traumatic injury, colic, erysipelas；Rhizoma Euonymus: medicinal part is the tree of Tengchong winged euonymus Skin.Gui Jing, property is put down, lightly seasoned.Enter Liver Channel.Curing mainly hemostasis, granulation promoting, control knife injury, water mill extract is put on the skin, or Grind to the powder and spread affected part；Radix Cirsii Japonici: medicinal part is the dry aerial parts of feverfew Ji.Sweet, cool.GUIXIN, Liver Channel.Cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, have blood in stool, metrorrhagia, traumatic hemorrhage, Carbuncle sore tumefacting virus；Squama Manis: this product is the scute of Manidae animal Squama Manis.Salty in the mouth；Cold nature.Enter liver, Stomach warp.Blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard, detumescence and apocenosis.Main blood stasis amenorrhea, lump in the abdomen, rheumatism Arthralgia pain, agalactia, carbuncle, scrofula.For amenorrhea abdominal mass, galactostasis, carbuncle sore tumefacting virus, joint numbness Bitterly, numbness contracture；Corium elephatis: for the skin of Elephantidae animal elephant, be used as medicine with plucked dry skin.It is sweet, salty, Temperature.GUIXIN, spleen channel.Granulation promoting, sore.Do not close up for skin infection；Radix Glycyrrhizae: medicinal part is that pulse family is planted The dry root of thing Radix Glycyrrhizae, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. and rhizome.Sweet in the mouth, property is put down.GUIXIN, lung, spleen, Stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, Fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion Toxicity, strong；Jojoba oil: containing the important natural complex of skin and the collagenic protein containing high nourishing degree, Mineral, can massage and protect skin, it is to avoid water loss, nourishes deep layer care skin, makes skin gloss There is elasticity, and relax the injury to skin of exposing to the weather.Again the base oil that permeability is the strongest, easily by Skin absorption, salubrious moist, non-greasy, can recover skin pH balance, remove wrinkle, be effectively improved oiliness skin Skin, nurses one's health smegma function, pore refining, is also optimal skin moisture-keeping oil simultaneously.It is formed Oil film different from mineral oil, can pass through evaporation moisture, also can control the loss of moisture.Its skin-friendly is very Good, it is the excellent medium that quintessence oil is brought into skin, the best to hair and beautifying skin.It has natural Moisten and Moisture factor, it is provided that skin-nourishing, make skin glossy, elastic, beautiful.It is suitable for any one Plant skin quality, give skin-nourishing, make the skin of fatigue reply original vigor, scalable oiliness or Combination The fat secretion of skin, and improve the skin of inflammation, eczema, chronic eczema, pimples etc. it can also be used to comedo, Eczema.It can highly desirable be dredged hair follicle and prevent sebum from accumulating in hair follicle, prevents from thus causing Alopecia；Propolis: propolis is the resin that Apis gathers from plant spore or trunk, is mixed into its palate A kind of colloidal solid thing with aromatic odor that gland, the secretions of wax gland process.It it is Apidae animal Apis ceranas etc. repair the yellowish-brown secreted by Nidus Vespae or the stickum of pitchy, can be used as medicine, include 20 big Class more than totally 300 plants nutritional labeling.Its property is put down, bitter in the mouth, pungent, micro-sweet, has skin moistening granulation promoting, anti-inflammatory analgetic Effect, also has antibacterial, antiviral, antiinflammatory, antipruritic, antioxidation, enhancing immunity, promotes cell regeneration Effect, gastric ulcer, oral ulcer, burn and scald, skin splitting pain can be treated, the disease such as radioprotective.

Mink mange and scab is a kind of epizoa property skin caused by the itch mite or acaricide parasitizing mink body surface Disease, is commonly called as leprosy, is a kind of parasitic dermatosis of mink, Vulpes, Nyctereutes procyonoides, and contagious infection, winter-spring season is easy Multiple.This disease infectiousness is very strong, and to be infected by contact with, the lighter makes animal become thin, and severe one causes death. Acaricide and the whole growth course of itch mite all complete on animal body.Acaricide digs chisel tunnel at host's epidermis, with skin Skin tissue, cell and lymph fluid are food, and grow and breeding at Intradermal.Itch mite then parasitizes skin surface, To suck skin transudate for food.

Clinical symptoms: itch mite takes place mostly in external auditory meatus, can cause otitis externa, and exudate is dried formation Yellow crust, fills up auditory meatus such as paper roll sample.Sick beast ear is sagging, constantly shakes the head and uses foot ear scratch piece, it is also possible to It is extended down to sieve skeleton and brain, sick beast performance torticollis, finally twitch and dead.

Acaricide is typically fallen ill by around mouth nose and claw portion, very itches, and sick beast constantly bites foot or use foot with mouth Scratch mouth, nose etc., when seriously itching before and after foot grab ground, pathological changes portion occurs that canescence sticks with paste block.Eyelet, nose Occurring scurf and blood crusts, lip swelling bottom beam, front foot plate surface and the rear foot, impact is searched for food, and sick beast disappears rapidly Thin, until dead.

So, the present invention, according to Chinese veterinarian's pharmacy, only have studied a kind of parasite killing removing toxic substances, bactericidal antiphlogistic, detumescence Itch, the Chinese medicine of expelling pus and promoting granulation is combined spray treatment mink mange and scab.

In formula, Cortex catalpae ovatae radicis compatibility Oleum Camelliae cake, Adeps sus domestica, dish, there is heat-clearing and toxic substances removing, parasite killing hemostasis Effect, first drive away or kill mink epiderm skin and the itch mite on surface, acaricide lamp parasite, remove because of The pyretic toxicity that parasite is caused, solves the cause of disease of mange and scab from root, is for monarch drug；Herba Thesii Longifolii expelling wind and clearing away heat, Inhibited to various bacteria, compatibility Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, on the basis of heat-clearing and toxic substances removing, Bactericidal antiphlogistic, prevents mink affected part wound infection antibacterial, is ministerial drug altogether；Rhizoma Polygonati Cirrhifolii, Symplocoris Paniculatae, Radix Chloranthi Serrati, red Semen Phaseoli, Folium Acanthopanacis Radicis have subduing swelling and detoxicating, effect of eliminating carbuncle pain relieving, eliminate carbuncle and the pain in affected part, make water Ermine does not stings affected part grabbing, and is adjuvant drug altogether；Rhizoma Euonymus, Radix Cirsii Japonici, Squama Manis, Corium elephatis, Radix Glycyrrhizae share there is heat clearing away Removing toxic substances, cooling blood for hemostasis, detumescence and apocenosis, the effect of expelling pus and promoting granulation, make illing skin cell regeneration, promotes wound Mouth healing, repairs epidermis, altogether for making medicine.Inventive formulation also added Jojoba oil, propolis as this Invention Chinese medicine is combined the basic medicine oil of spray so that spray of the present invention is easy to be attached on illing skin be difficult to Coming off, the other drug effective ingredient in formula is easily absorbed by the skin, and plays drug effect, Jojoba oil, honeybee Glue can also anti-inflammation, promote cell metabolism, accelerate the healing of histiocytic regeneration and wound, promote Water inlet ermine mange and scab quickly-healing.

The present invention also provides for a kind of Chinese medicine treating mink mange and scab and is combined the preparation method of spray, including following Step:

(1) taking Oleum Camelliae cake, be fired to outside withered black, the inside is sallow dries in the air cool for spending, standby；

(2) taking clean Squama Manis, according to boiling hot method stir-baking in sand to heaving, vinegar is quenched, and takes out, and is dried, standby, every 100kg Squama Manis, uses vinegar 30kg；

(3) first Pulvis Talci is poured in pot and heats, pour Corium elephatis into, scald to heaving and during in coke yellow, take out, Sieve removes Pulvis Talci, cools, standby；

(4) after little for Semen Phaseoli fire being fried, Oleum Camelliae cake after processing respectively with step (1)-(3), Squama Manis, Corium elephatis mixes, and then carries out micronizing, crosses 325 mesh mesh screens, obtains mixing superfine powder；

(5) by grounds travel after Cortex catalpae ovatae radicis, Herba Thesii Longifolii, Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, Symplocoris Paniculatae, Radix Glycyrrhizae mixing Being broken to 80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h at 50 ± 5 DEG C, Then said medicine and liquid being collectively disposed in microwave extracting tank and extract, controlling microwave frequency is 1000MHz, microwave power is 120W/L, carries out microwave radiation, then the operating pressure in extractor is existed Stepping up in 5-10min to 0.2MPa, microwave irradiation time amounts to 30min, obtains microwave extracting liquid；

(6) choose fresh dish, Rhizoma Polygonati Cirrhifolii, Radix Chloranthi Serrati, Folium Acanthopanacis Radicis, Rhizoma Euonymus, Radix Cirsii Japonici, clean up After, add step (5) gained extract and be ground squeezing the juice, filter to get filtrate after standing 30min；

(7) by Adeps sus domestica, Jojoba oil, propolis mixing, heat while stirring, to the most melted, then Be sequentially added under agitation step (6) prepare filtrate, step (4) prepare mixing superfine powder, Mix homogeneously, total amount is designated as 1, is subsequently adding 4 parts of sterilized water, carries out homogenizing, sterilizing, fill, obtain institute The Chinese medicine stating treatment mink mange and scab is combined spray.

Using method: by affected part and being cut off by hair at 3-4cm about, thoroughly scrub with temperature suds, Remove hard crust and dirt, then the Chinese medicine of the present invention is combined spray and is sprayed into affected part and 3-4cm about Place, sprays twice every day.

In preparation method of the present invention, by Cortex catalpae ovatae radicis, Herba Thesii Longifolii, Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, Symplocoris Paniculatae, sweet At 50 ± 5 DEG C, soak 1h with the mixed liquor without sterilized water and ethanol after grass meal is broken, sterilized water and second can be made The cell interior that alcohol molecule crushes well into cell wall, fully infiltrates medical material so that medical material is at microwave extracting Time, microwave heating makes solvent sterilized water, toluene and ethanol absorb microwave energy and produces substantial amounts of thermal energy, makes born of the same parents Interior temperature rises rapidly, and cell membrane and cell wall are broken through by the pressure of generation further, is formed some small Hole, until crackle occurs in cell surface, makes solvent enter cell interior more fully, and microwave can also promote Molecule in solvent quickly rotates and moves, and especially water, these polar molecules of ethanol can be made at microwave Intensify with lower generation moment, produce the vibration of key, tear and interparticle friction and collision, and be quickly generated A large amount of heat energy, strong in cell interior penetration power, promote cell to continue to rupture, make having in Cell sap and medicine Effect composition quickly overflows and diffuses in solvent, substantially reduces the extraction time of effective ingredient, greatly Improve extraction efficiency, and microwave heating is uniform, belongs to intraor extracellular and heats simultaneously, it is to avoid traditional extraction Taking thermograde during heating, medical material heated time is short, the beneficially extraction of effective ingredient in medical material.Additionally Microwave extracting can extract the effective ingredient in medical material in high volume, and solvent load is less than traditional handicraft, side simultaneously Extract concentrated by subsequent step purify, time-consuming；Extract is spray-dried and after micronizing Again dissolve, the impurity in Chinese medicine extract after fine straining, can be eliminated to greatest extent.

In the preparation method of the present invention, by fresh dish, Rhizoma Polygonati Cirrhifolii, Radix Chloranthi Serrati, Folium Acanthopanacis Radicis, Rhizoma Euonymus, Radix Cirsii Japonici, after cleaning up, is ground squeezing the juice with step (5) gained extract, is not required to still further add water Or other materials are ground so that extract and squeeze the juice filtrate can be time-consuming with disposable filtering.

Beneficial effects of the present invention:

(1) present invention is according to Chinese veterinarian's pharmacy, have studied a kind of parasite killing removing toxic substances, bactericidal antiphlogistic, repellent antipruritic, The Chinese medicine of expelling pus and promoting granulation is combined spray treatment mink mange and scab.In formula, Cortex catalpae ovatae radicis compatibility Oleum Camelliae cake, leaf fat Cream, dish, have heat-clearing and toxic substances removing, the effect of parasite killing hemostasis, first drive away or kill mink epiderm skin And the itch mite on surface, acaricide lamp parasite, remove the pyretic toxicity caused because of parasite, from root, solve scabies The sick cause of disease；Herba Thesii Longifolii expelling wind and clearing away heat, inhibited to various bacteria, compatibility Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, on the basis of heat-clearing and toxic substances removing, bactericidal antiphlogistic, prevent mink affected part wound infection antibacterial；Rhizoma Polygonati Cirrhifolii, Symplocoris Paniculatae, Radix Chloranthi Serrati, Semen Phaseoli, Folium Acanthopanacis Radicis have subduing swelling and detoxicating, effect of eliminating carbuncle pain relieving, eliminate the carbuncle in affected part Swollen and pain, makes mink not sting affected part grabbing；Rhizoma Euonymus, Radix Cirsii Japonici, Squama Manis, Corium elephatis, Radix Glycyrrhizae share have Heat-clearing and toxic substances removing, cooling blood for hemostasis, detumescence and apocenosis, the effect of expelling pus and promoting granulation, make illing skin cell regeneration, promotees Enter wound healing, repair epidermis.Inventive formulation also added Jojoba oil, propolis as in the present invention Recurrence due to taking drug closes the basic medicine oil of spray so that spray of the present invention is easy to be attached to difficult drop-off on illing skin, Other drug effective ingredient in formula is easily absorbed by the skin, and plays drug effect, and Jojoba oil, propolis can also Anti-inflammation, promotes cell metabolism, accelerates the healing of histiocytic regeneration and wound, promotes mink Mange and scab quickly-healing.

(2) in preparation method of the present invention, by Cortex catalpae ovatae radicis, Herba Thesii Longifolii, Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, Symplocoris Paniculatae, Radix Glycyrrhizae soaks 1h with without the mixed liquor of sterilized water and ethanol after pulverizing at 50 ± 5 DEG C, can make sterilized water with The cell interior that ethanol molecule crushes well into cell wall, fully infiltrates medical material so that medical material extracts at microwave When taking, microwave heating makes solvent sterilized water, toluene and ethanol absorb microwave energy and produces substantial amounts of thermal energy, makes Intracellular temperature rises rapidly, and cell membrane and cell wall are broken through by the pressure of generation further, is formed some micro- Small holes, until crackle occurs in cell surface, makes solvent enter cell interior more fully, and microwave can also promote Enter the molecule in solvent quickly rotate and move, especially water, these polar molecules of ethanol can be at microwave Effect lower generation moment intensifies, and produces the vibration of key, tear and interparticle friction and collision, and gives birth to rapidly Become a large amount of heat energy, strong in cell interior penetration power, promote cell to continue to rupture, make in Cell sap and medicine Effective ingredient quickly overflows and diffuses in solvent, substantially reduces the extraction time of effective ingredient, pole The earth improves extraction efficiency, and microwave heating is uniform, belongs to intraor extracellular and heats simultaneously, it is to avoid tradition Thermograde during extraction heating, medical material heated time is short, the beneficially extraction of effective ingredient in medical material.Separately Outer microwave extracting can extract the effective ingredient in medical material in high volume, and solvent load is less than traditional handicraft simultaneously, Facilitate extract is concentrated by subsequent step and purify, time-consuming；Extract is spray-dried and micronizing After again dissolve, the impurity in Chinese medicine extract can be eliminated after fine straining to greatest extent.

(3) in the preparation method of the present invention, by fresh dish, Rhizoma Polygonati Cirrhifolii, Radix Chloranthi Serrati, Folium Acanthopanacis Radicis, white Skin, Radix Cirsii Japonici, after cleaning up, be ground squeezing the juice with step (5) gained extract, be not required to still further add Enter water or other materials be ground so that extract and squeeze the juice filtrate can be time-consuming with disposable filtering.

(4) Chinese medicine of the present invention is combined spray using natural Chinese medicinal herb as raw material, can play and effectively prevent and treat mink The effect of mange and scab, safe and convenient to use, effective, adult ermine and young ermine are all had no side effect, it oozes The easy metabolism of residual components entering skin is got rid of, and is conducive to improving the economic benefit of raiser.

Detailed description of the invention

Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described.

Embodiment 1

A kind of Chinese medicine treating mink mange and scab is combined spray, is made up of each component of following parts by weight: Chinese catalpa Rhizoma Euonymus 10 parts, Oleum Camelliae cake 4 parts, Adeps sus domestica 5 parts, dish 50 parts, Herba Thesii Longifolii 10 parts, Fructus Momordicae charantiae 20 Part, Radix Rumicis Patientiae 10 parts, Radix Ampelopsis 5 parts, Rhizoma Polygonati Cirrhifolii 10 parts, Symplocoris Paniculatae 10 parts, Radix Chloranthi Serrati 10 parts, Semen Phaseoli 10 parts, Folium Acanthopanacis Radicis 8 parts, Rhizoma Euonymus 6 parts, Radix Cirsii Japonici 20 parts, Squama Manis 5 parts, Corium elephatis 3 parts, 6 parts of Radix Glycyrrhizae, Jojoba oil 6 parts, propolis 6 parts.

The Chinese medicine of described treatment mink mange and scab is combined the preparation method of spray, comprises the following steps:

(1) taking Oleum Camelliae cake, be fired to outside withered black, the inside is sallow dries in the air cool for spending, standby；

(2) taking clean Squama Manis, according to boiling hot method stir-baking in sand to heaving, vinegar is quenched, and takes out, and is dried, standby, every 100kg Squama Manis, uses vinegar 30kg；

(3) first Pulvis Talci is poured in pot and heats, pour Corium elephatis into, scald to heaving and during in coke yellow, take out, Sieve removes Pulvis Talci, cools, standby；

(4) after little for Semen Phaseoli fire being fried, Oleum Camelliae cake after processing respectively with step (1)-(3), Squama Manis, Corium elephatis mixes, and then carries out micronizing, crosses 325 mesh mesh screens, obtains mixing superfine powder；

(5) by grounds travel after Cortex catalpae ovatae radicis, Herba Thesii Longifolii, Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, Symplocoris Paniculatae, Radix Glycyrrhizae mixing Being broken to 80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h at 50 ± 5 DEG C, Then said medicine and liquid being collectively disposed in microwave extracting tank and extract, controlling microwave frequency is 1000MHz, microwave power is 120W/L, carries out microwave radiation, then the operating pressure in extractor is existed Stepping up in 5-10min to 0.2MPa, microwave irradiation time amounts to 30min, obtains microwave extracting liquid；

(6) choose fresh dish, Rhizoma Polygonati Cirrhifolii, Radix Chloranthi Serrati, Folium Acanthopanacis Radicis, Rhizoma Euonymus, Radix Cirsii Japonici, clean up After, add step (5) gained extract and be ground squeezing the juice, filter to get filtrate after standing 30min；

(7) by Adeps sus domestica, Jojoba oil, propolis mixing, heat while stirring, to the most melted, then Be sequentially added under agitation step (6) prepare filtrate, step (4) prepare mixing superfine powder, Mix homogeneously, total amount is designated as 1, is subsequently adding 4 parts of sterilized water, carries out homogenizing, sterilizing, fill, obtain institute The Chinese medicine stating treatment mink mange and scab is combined spray.

Embodiment 2

A kind of Chinese medicine treating mink mange and scab is combined spray, is made up of each component of following parts by weight: Chinese catalpa Rhizoma Euonymus 20 parts, Oleum Camelliae cake 8 parts, Adeps sus domestica 10 parts, dish 80 parts, Herba Thesii Longifolii 18 parts, Fructus Momordicae charantiae 40 Part, Radix Rumicis Patientiae 20 parts, Radix Ampelopsis 11 parts, Rhizoma Polygonati Cirrhifolii 30 parts, Symplocoris Paniculatae 20 parts, Radix Chloranthi Serrati 30 parts, Semen Phaseoli 20 parts, Folium Acanthopanacis Radicis 18 parts, Rhizoma Euonymus 12 parts, Radix Cirsii Japonici 40 parts, Squama Manis 9 parts, Corium elephatis 5 parts, Radix Glycyrrhizae 12 parts, Jojoba oil 10 parts, propolis 12 parts.

The preparation method of the present embodiment is identical with the preparation method of embodiment 1.

Embodiment 3

A kind of Chinese medicine treating mink mange and scab is combined spray, is made up of each component of following parts by weight: Chinese catalpa Rhizoma Euonymus 15 parts, Oleum Camelliae cake 6 parts, Adeps sus domestica 8 parts, dish 65 parts, Herba Thesii Longifolii 14 parts, Fructus Momordicae charantiae 30 Part, Radix Rumicis Patientiae 15 parts, Radix Ampelopsis 8 parts, Rhizoma Polygonati Cirrhifolii 20 parts, Symplocoris Paniculatae 15 parts, Radix Chloranthi Serrati 20 parts, Semen Phaseoli 15 parts, Folium Acanthopanacis Radicis 13 parts, Rhizoma Euonymus 9 parts, Radix Cirsii Japonici 30 parts, Squama Manis 7 parts, Corium elephatis 4 parts, Radix Glycyrrhizae 9 Part, Jojoba oil 8 parts, propolis 9 parts.

The preparation method of the present embodiment is identical with the preparation method of embodiment 1.

Chinese medicine of the present invention is combined spray effect test

Embodiment 4 animal toxicity is tested

Acute dermal toxicity is tested

Long-term percutaneous toxicity test:

Selecting healthy adult rat 30, male and female half and half, body weight is suitable, all between 180-220Kg, greatly Mus skin health is without breakage.It is classified as 3 groups, often organizes the spraying embodiment of the present invention 1,2,3 preparation respectively Chinese medicine compound spray, test before rat in experimental animal room environment, adapt to the 4d time.Before on-test 24h, shave except rat trunk back intend contamination region by hair, answer extreme care, not injured skin during unhairing In order to avoid cutaneous permeability.It is coated with the long-pending about 160cm of surface².In prepared by embodiment of the present invention 1-3 Recurrence due to taking drug side's spray even application, in rat dorsum skin chemical contaminated zone, then covers, with stingless with one layer of thin film Swash immobilization with adhesive tape, prevent animal from licking.Continuous spray 30 days, experimental rat overall health of patients, diet, drinking-water, Body weight increases all normal, obvious intoxicating phenomenon and the phenomena of mortality does not occurs, locates post mortem Non Apparent Abnormality, Judge that the true border of this Chinese medicine compound spray percutaneous toxicity long-term to adult rat is nontoxic.

Embodiment 5 therapeutic test

EXPERIMENTAL DESIGN and packet:

Choose 50 minks suffering from mange and scab, be randomly divided into five groups, often group 10.Cardinal symptom is head There is tuberosity in portion, eye limit, skin of neck, flow out transudate, dried crust or be full of cracks, external ear at tuberosity Having exudate in road, ear is sagging, constantly shake the head and use foot ear scratch piece, mouth nose, claw position occur scurf or Blood crusts, very itches, lip swelling, and impact is searched for food, lean body mass.

Often group carries out following operation:

First group: do not do any operation.

Second group: by affected part and being cut off by hair at 3-4cm about, thoroughly scrub with temperature suds, remove Falling hard crust and dirt, coating quality concentration is the metrifonate solution of 5%, sprays twice every day.

3rd group: by affected part and being cut off by hair at 3-4cm about, thoroughly scrub with temperature suds, remove Fall hard crust and dirt, then the Chinese medicine of embodiment 1 is combined spray and is sprayed into affected part and 3-4cm about Place, sprays twice every day.

4th group: by affected part and being cut off by hair at 3-4cm about, thoroughly scrub with temperature suds, remove Fall hard crust and dirt, then the Chinese medicine of embodiment 2 is combined spray and is sprayed into affected part and 3-4cm about Place, sprays twice every day.

5th group: by affected part and being cut off by hair at 3-4cm about, thoroughly scrub with temperature suds, remove Fall hard crust and dirt, then the Chinese medicine of embodiment 3 is combined spray and is sprayed into affected part and 3-4cm about Place, sprays twice every day.

Test index:

When clinical health and analyse observation: the physical condition of observational record experiment every day mink, recover. If any mink death, record death time and symptom in test.

Statistical test mink morbidity death and cure rate situation after 30 days, concrete data are shown in Table 1.

The death of table 1 mink and cure rate situation

Group	Test number/only	Death toll/only	Mortality rate	Recovery from illness number/only	Cure rate	Cure natural law used
							First group	10	7	70%	0	0	——
Second group	10	1	10%	1	10%	24
							3rd group	10	0	0	8	80%	7
4th group	10	0	0	9	90%	8
							5th group	10	0	0	10	100%	7

From the data of table 1 it can be seen that the Chinese medicine of the present invention is combined spray has mink and well treat effect Really, cure rate is high, and healing time is short.

The above is the preferred embodiment of the present invention, its object is to allow person skilled in the art understand Present invention is also carried out, it is noted that for those skilled in the art, Without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications are also It is considered as protection scope of the present invention.

Claims (5)

1. the Chinese medicine treating mink mange and scab is combined spray, it is characterised in that by following parts by weight Each component is made: Cortex catalpae ovatae radicis 10-20 part, Oleum Camelliae cake 4-8 part, Adeps sus domestica 5-10 part, dish 50-80 Part, Herba Thesii Longifolii 10-18 part, Fructus Momordicae charantiae 20-40 part, Radix Rumicis Patientiae 10-20 part, Radix Ampelopsis 5-11 part, Rhizoma Polygonati Cirrhifolii 10-30 part, Symplocoris Paniculatae 10-20 part, Radix Chloranthi Serrati 10-30 part, Semen Phaseoli 10-20 part, Folium Acanthopanacis Radicis 8-18 part, white Skin 6-12 part, Radix Cirsii Japonici 20-40 part, Squama Manis 5-9 part, Corium elephatis 3-5 part, Radix Glycyrrhizae 6-12 part, jojoba Oil 6-10 part, propolis 6-12 part.

A kind of Chinese medicine treating mink mange and scab is combined spray, it is characterised in that Be made up of each component of following parts by weight: Cortex catalpae ovatae radicis 10 parts, Oleum Camelliae cake 4 parts, Adeps sus domestica 5 parts, Dish 50 parts, Herba Thesii Longifolii 10 parts, 20 parts of Fructus Momordicae charantiae, Radix Rumicis Patientiae 10 parts, Radix Ampelopsis 5 parts, Rhizoma Polygonati Cirrhifolii 10 parts, Symplocoris Paniculatae 10 parts, Radix Chloranthi Serrati 10 parts, Semen Phaseoli 10 parts, Folium Acanthopanacis Radicis 8 parts, Rhizoma Euonymus 6 parts, Radix Cirsii Japonici 20 parts, Squama Manis 5 parts, Corium elephatis 3 parts, 6 parts of Radix Glycyrrhizae, Jojoba oil 6 parts, propolis 6 parts.

A kind of Chinese medicine treating mink mange and scab is combined spray, it is characterised in that Be made up of each component of following parts by weight: Cortex catalpae ovatae radicis 20 parts, Oleum Camelliae cake 8 parts, Adeps sus domestica 10 parts, Dish 80 parts, Herba Thesii Longifolii 18 parts, 40 parts of Fructus Momordicae charantiae, Radix Rumicis Patientiae 20 parts, Radix Ampelopsis 11 parts, Rhizoma Polygonati Cirrhifolii 30 Part, Symplocoris Paniculatae 20 parts, Radix Chloranthi Serrati 30 parts, Semen Phaseoli 20 parts, Folium Acanthopanacis Radicis 18 parts, Rhizoma Euonymus 12 parts, Radix Cirsii Japonici 40 Part, Squama Manis 9 parts, Corium elephatis 5 parts, 12 parts of Radix Glycyrrhizae, Jojoba oil 10 parts, propolis 12 parts.

A kind of Chinese medicine treating mink mange and scab is combined spray, it is characterised in that Be made up of each component of following parts by weight: Cortex catalpae ovatae radicis 15 parts, Oleum Camelliae cake 6 parts, Adeps sus domestica 8 parts, Dish 65 parts, Herba Thesii Longifolii 14 parts, 30 parts of Fructus Momordicae charantiae, Radix Rumicis Patientiae 15 parts, Radix Ampelopsis 8 parts, Rhizoma Polygonati Cirrhifolii 20 parts, Symplocoris Paniculatae 15 parts, Radix Chloranthi Serrati 20 parts, Semen Phaseoli 15 parts, Folium Acanthopanacis Radicis 13 parts, Rhizoma Euonymus 9 parts, Radix Cirsii Japonici 30 parts, Squama Manis 7 parts, Corium elephatis 4 parts, 9 parts of Radix Glycyrrhizae, Jojoba oil 8 parts, propolis 9 parts.

5. the Chinese medicine of the treatment mink mange and scab described in any one of claim 1-4 is combined the preparation method of spray, It is characterized in that, comprise the following steps:

(1) taking Oleum Camelliae cake, be fired to outside withered black, the inside is sallow dries in the air cool for spending, standby；

(2) taking clean Squama Manis, according to boiling hot method stir-baking in sand to heaving, vinegar is quenched, and takes out, and is dried, standby, every 100kg Squama Manis, uses vinegar 30kg；

(3) first Pulvis Talci is poured in pot and heat, pour Corium elephatis into, scald to heaving and during in coke yellow, take Going out, sieve removes Pulvis Talci, cools, standby；

(4) after little for Semen Phaseoli fire being fried, Oleum Camelliae cake after processing respectively with step (1)-(3), Squama Manis, Corium elephatis mixes, and then carries out micronizing, crosses 325 mesh mesh screens, obtains mixing superfine powder；

(5) by grounds travel after Cortex catalpae ovatae radicis, Herba Thesii Longifolii, Fructus Momordicae charantiae, Radix Rumicis Patientiae, Radix Ampelopsis, Symplocoris Paniculatae, Radix Glycyrrhizae mixing Being broken to 80 mesh, gross weight is designated as 1 part, adds 3 parts of sterilized water, 1 part of ethanol, soaks 1h at 50 ± 5 DEG C, Then said medicine and liquid being collectively disposed in microwave extracting tank and extract, controlling microwave frequency is 1000MHz, microwave power is 120W/L, carries out microwave radiation, then the operating pressure in extractor is existed Stepping up in 5-10min to 0.2MPa, microwave irradiation time amounts to 30min, obtains microwave extracting liquid；

(6) choose fresh dish, Rhizoma Polygonati Cirrhifolii, Radix Chloranthi Serrati, Folium Acanthopanacis Radicis, Rhizoma Euonymus, Radix Cirsii Japonici, clean up After, add step (5) gained extract and be ground squeezing the juice, filter to get filtrate after standing 30min；

(7) by Adeps sus domestica, Jojoba oil, propolis mixing, heat while stirring, to the most melted, then Be sequentially added under agitation step (6) prepare filtrate, step (4) prepare mixing superfine powder, Mix homogeneously, total amount is designated as 1, is subsequently adding 4 parts of sterilized water, carries out homogenizing, sterilizing, fill, obtain institute The Chinese medicine stating treatment mink mange and scab is combined spray.