CN105998386B - Liver-protecting millettia speciosa champ composition, preparation method and application thereof - Google Patents
Liver-protecting millettia speciosa champ composition, preparation method and application thereof Download PDFInfo
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- CN105998386B CN105998386B CN201610309823.1A CN201610309823A CN105998386B CN 105998386 B CN105998386 B CN 105998386B CN 201610309823 A CN201610309823 A CN 201610309823A CN 105998386 B CN105998386 B CN 105998386B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention relates to the field of health care products, in particular to a beautiful millettia root composition for protecting liver, a preparation method and application thereof. The bovine powerful composition for protecting the liver comprises the following components in parts by weight: 10-50 parts of beautiful millettia root, 5-20 parts of aquilaria sinensis, 5-15 parts of desmodium triquetrum, 5-30 parts of ligusticum wallichii, 10-30 parts of felon paniculata, 10-30 parts of paederia scandens, 5-15 parts of hypericum japonicum and 5-15 parts of immature bitter orange. The invention also provides a preparation method of the millettia speciosa champ composition for protecting the liver. The composition can be used for preparing a preparation with the effect of protecting the liver, and has obvious curative effect.
Description
Technical Field
The invention relates to the field of health care products, in particular to a beautiful millettia root composition for protecting liver, a preparation method and application thereof.
Background
The liver is an organ essential for life maintenance, and is an organ mainly responsible for metabolic functions in the body, and plays a role in detoxifying, storing hepatic glycogen, synthesizing secretory proteins, and the like in the body. The liver is not only the largest digestive organ of the human body, but also an important detoxifying organ in the human body. In traditional Chinese medicine, the liver belongs to wood, prefers dryness, mainly relieves diarrhea and excessive symptoms, so that purging is mostly adopted for treating and nourishing the liver. Emotion, sleep, diet, drugs, etc. all can affect the function of the liver to smooth flow of qi. The incidence of hepatitis, fatty liver, alcoholic liver, liver cirrhosis, hepatic cyst, liver cancer and other diseases has increased in successive years, with liver cancer being the most serious. Liver cancer is difficult to cure once it is ill, and the onset and death of the disease are fast.
Most liver diseases do not have particularly significant symptoms at the initial stage, and it is difficult to judge whether a liver disease is obtained from superficial diagnosis or conjecture. Therefore, the liver protection in daily life is very important.
Disclosure of Invention
The millettia speciosa champ composition for protecting the liver, the preparation method and the application thereof provided by the invention can comprehensively regulate the liver function and have a remarkable liver protecting effect.
The technical scheme of the invention is realized as follows:
the bovine powerful composition for protecting the liver comprises the following components in parts by weight: 10-50 parts of beautiful millettia root, 5-20 parts of aquilaria sinensis, 5-15 parts of desmodium triquetrum, 5-30 parts of ligusticum wallichii, 10-30 parts of orthosiphon aristatus, 10-30 parts of paederia scandens, 5-15 parts of hypericum japonicum and 5-15 parts of immature bitter orange.
Further, the millettia speciosa champ composition for protecting the liver comprises the following components in parts by weight: 20-30 parts of beautiful millettia root, 10-15 parts of aquilaria sinensis, 8-10 parts of desmodium triquetrum, 10-20 parts of ligusticum wallichii, 15-20 parts of orthosiphon aristatus, 15-20 parts of paederia scandens, 8-10 parts of hypericum japonicum and 8-10 parts of immature bitter orange.
A medicine for protecting liver is the water extraction and alcohol precipitation of the beautiful millettia root composition.
The preparation method of the liver-protecting medicine comprises the following steps:
(1) decocting the beautiful millettia root composition in water, and filtering to remove dregs to obtain filtrate;
(2) concentrating the filtrate under reduced pressure, adding ethanol, adjusting the volume concentration of the ethanol to be 80-95%, standing, removing supernatant, and drying to obtain the beautiful millettia root composition.
Further, in the step (1), the millettia speciosa champ is crushed before being decocted, the water adding amount is 5-8 times of the total weight of the medicinal materials, and the decoction is carried out for 3 times.
Further, in the filtrate reduced pressure concentration process in the step (2), controlling the temperature to be 50-70 ℃, and concentrating to the volume of 30-50% of the original volume of the filtrate; standing for 12-20 h; the drying method is spray drying or freeze drying.
The millettia speciosa champ composition for protecting the liver, or the medicament for protecting the liver prepared by the preparation method is applied to the preparation of the preparation with the effect of protecting the liver.
A preparation for protecting liver comprises the composition for moistening lung to arrest cough, the medicine for protecting liver, or the medicine for protecting liver prepared by any one of the preparation methods.
Further, the preparation is capsules, pills, tablets or granules.
The invention has the beneficial effects that:
beautiful millettia root, radix Millettiae Speciosae, tonifying deficiency and moistening lung, strengthening tendons and activating collaterals. Can be used for treating lumbar muscle strain, rheumatic arthritis, lung heat, cough due to lung deficiency, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, spermatorrhea, and leucorrhea.
Radix Aristolochiae, radix aucklandiae, promotes the circulation of qi to relieve pain; lowering the adverse flow of qi in the middle-warmer; receive qi and relieve dyspnea.
The calabash tea has the effects of clearing heat and removing toxicity, promoting diuresis and removing jaundice, and removing food retention and killing parasites, and is mainly used for treating heatstroke and polydipsia, cold and fever, sore throat, lung disease and hemoptysis, nephritis, infantile malnutrition, jaundice, diarrhea, dysentery, rheumatic arthralgia, ancylostomiasis and scabies.
Orthosiphon aristatus has effects of clearing heat and removing dampness, and removing urinary calculus and promoting diuresis. It can be used for treating acute nephritis, cystitis, lithangiuria, and rheumatic arthritis.
The Chinese fevervine herb has the functions of dispelling wind, promoting blood circulation, relieving pain, detoxifying, promoting digestion, removing stagnation, removing dampness and reducing swelling. Can be used for treating rheumatalgia, diarrhea, dysentery, abdominal pain, qi deficiency, edema, dizziness, anorexia, hepatosplenomegaly, lymphoid tuberculosis, acute appendicitis, undefined lump, and traumatic injury.
Herba Hyperici Japonici for clearing heat and promoting diuresis; detoxification; dispel stasis and relieve swelling. Jaundice due to damp-heat pathogen; diarrhea; dysentery; intestinal abscess; carbuncle and furuncle; a latex moth; aphtha; conjunctival congestion with swelling and pain; bite by poisonous snake; traumatic injury
Immature bitter orange, accumulation and stagnation; fullness and distending pain; constipation; severe diarrhea and dysentery; forming a breast; gastroptosis; uterine prolapse; rectocele.
The ligusticum wallichii is used for activating blood and promoting qi circulation, dispelling wind and relieving pain, and the qi in blood is pungent, warm, fragrant and dry, and can disperse and ascend to the vertex; it enters the blood system and goes down to reach the blood sea.
According to the liver protecting composition, due to the compatibility of the components, the desmodium triquetrum and hypericum japonicum have good functions of clearing heat, promoting diuresis and removing toxicity, and the Chinese fevervine has the functions of promoting blood circulation, removing toxicity, removing dampness and reducing swelling, so that the functions of clearing heat, removing toxicity, promoting diuresis and reducing swelling are greatly improved, liver fire can be effectively cleared, toxicity can be removed, dampness and heat can be removed, and the burden of the liver can be relieved. The beautiful millettia root has the effects of tonifying deficiency and strengthening bones and muscles, and can effectively strengthen the kidney and tonify deficiency, enhance the body constitution, excite the functions of viscera and enhance the immunity of the organism by being assisted with the effects of eliminating dampness and inducing diuresis of the Orthosiphon aristatus. The aquilaria sinensis can promote qi circulation, and the immature bitter orange can remove food retention, so that the functions of regulating qi movement in vivo, promoting qi circulation and removing food retention and enhancing the catharsis function of the liver can be effectively achieved. The rhizoma ligustici wallichii is capable of enriching and activating blood, increasing blood supply of the liver and facilitating adjustment and recovery of various functions of the liver. The medicinal materials are compatible for use, have mutual harmonization and mutual promotion of the effects of clearing heat, detoxifying, activating blood, promoting qi circulation and replenishing blood, can relieve the liver burden, can regulate the qi activity in a body, maintain the catharsis function of the liver, increase the liver nutrition, improve the blood supply of the liver and comprehensively regulate the liver function. Meanwhile, the medicine has the effects of reinforcing the kidney, tonifying deficiency, consolidating body constitution and cultivating primordial qi, is beneficial to exerting the medicine effect, restoring the balance of yin and yang in a body, improving the immunity of the body, reducing the damage of various factors to the liver, fundamentally solving the damage of various adverse factors to the liver, consolidating the medicine effect and achieving the purpose of protecting the liver. Can be used for preparing various preparations, and has obvious liver protecting effect.
Detailed Description
The technical solutions in the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The millettia speciosa champ composition for protecting the liver comprises the following components: 10g of beautiful millettia root, 5g of aquilaria sinensis, 5g of desmodium triquetrum, 5g of ligusticum wallichii, 10g of orthosiphon aristatus, 10g of paederia scandens, 5g of hypericum japonicum and 5g of immature bitter orange.
The preparation method of the millettia speciosa champ composition for protecting the liver comprises the following steps:
(1) taking beautiful millettia root, costus root, desmodium triquetrum, szechuan lovage rhizome, Chinese alpine rush, Chinese fevervine herb, hypericum japonicum thunb and immature bitter orange according to the formula amount, crushing, adding water accounting for 5 times of the total weight of medicinal materials for decocting, and filtering to remove medicinal residues to obtain filtrate; decocting for 3 times, and mixing filtrates;
(2) concentrating the filtrate under reduced pressure to 30% of the total volume of the filtrate, controlling the temperature at 50 deg.C during the concentration process, adjusting ethanol concentration to 80%, standing for 12h, removing supernatant, and spray drying or freeze drying to obtain the radix Millettiae Speciosae composition.
The millettia speciosa champ composition for protecting the liver can be used for preparing a preparation with the effect of protecting the liver.
Example 2
The bovine powerful composition for protecting the liver comprises the following components in parts by weight: 50g of beautiful millettia root, 20g of aquilaria sinensis, 15g of desmodium triquetrum, 30g of ligusticum wallichii, 30g of orthosiphon aristatus, 30g of paederia scandens, 15g of hypericum japonicum and 15g of immature bitter orange.
The preparation method of the millettia speciosa champ composition for protecting the liver comprises the following steps:
(1) taking beautiful millettia root, costus root, desmodium triquetrum, szechuan lovage rhizome, Chinese alpine rush, Chinese fevervine herb, hypericum japonicum thunb and immature bitter orange according to the formula amount, crushing, adding water accounting for 8 times of the total weight of medicinal materials for decocting, and filtering to remove medicinal residues to obtain filtrate; decocting for 3 times, and mixing filtrates;
(2) and concentrating the filtrate under reduced pressure until the volume of the filtrate is 50% of the total volume of the filtrate, controlling the temperature at 70 ℃ in the filtrate reduced pressure concentration process, adjusting the ethanol concentration to 95% by volume, standing for 20h, removing supernatant, and performing spray drying or freeze drying to obtain the beautiful millettia root composition.
The millettia speciosa champ composition for protecting the liver can be used for preparing a preparation with the effect of protecting the liver.
Example 3
The bovine powerful composition for protecting the liver comprises the following components in parts by weight: 20g of beautiful millettia root, 10g of aquilaria sinensis, 8g of desmodium triquetrum, 10g of ligusticum wallichii, 15g of orthosiphon aristatus, 15g of paederia scandens, 8g of hypericum japonicum and 8g of immature bitter orange.
The preparation method of the millettia speciosa champ composition for protecting the liver comprises the following steps:
(1) taking beautiful millettia root, costus root, desmodium triquetrum, szechuan lovage rhizome, Chinese alpine rush, Chinese fevervine herb, hypericum japonicum thunb and immature bitter orange according to the formula amount, crushing, adding water accounting for 6 times of the total weight of medicinal materials, decocting, filtering and removing dregs to obtain filtrate; decocting for 3 times, and mixing filtrates;
(2) and concentrating the filtrate under reduced pressure to 40% of the total volume of the filtrate, controlling the temperature at 60 ℃ in the filtrate reduced pressure concentration process, adjusting the ethanol concentration to 90% of the volume concentration, standing for 15h, removing supernatant, and performing spray drying or freeze drying to obtain the beautiful millettia root composition.
The millettia speciosa champ composition for protecting the liver can be used for preparing a preparation with the effect of protecting the liver.
Example 4
The bovine powerful composition for protecting the liver comprises the following components in parts by weight: 30g of beautiful millettia root, 15g of aquilaria sinensis, 10g of desmodium triquetrum, 20g of ligusticum wallichii, 20g of orthosiphon aristatus, 20g of paederia scandens, 10g of hypericum japonicum and 10g of immature bitter orange.
The preparation method of the millettia speciosa champ composition for protecting the liver comprises the following steps:
(1) taking beautiful millettia root, costus root, desmodium triquetrum, szechuan lovage rhizome, Chinese alpine rush, Chinese fevervine herb, hypericum japonicum thunb and immature bitter orange according to the formula amount, crushing, adding water with the weight 7 times of the total weight of medicinal materials for decocting, and filtering to remove medicinal residues to obtain filtrate; decocting for 3 times, and mixing filtrates;
(2) and concentrating the filtrate under reduced pressure to 45% of the total volume of the filtrate, controlling the temperature to be 55 ℃ in the filtrate reduced pressure concentration process, adjusting the ethanol concentration to 85% of the volume concentration, standing for 18h, removing supernatant, and performing spray drying or freeze drying to obtain the beautiful millettia root composition.
The millettia speciosa champ composition for protecting the liver can be used for preparing a preparation with the effect of protecting the liver.
Example 5
The bovine powerful composition for protecting the liver comprises the following components in parts by weight: 25g of beautiful millettia root, 12g of aquilaria sinensis, 9g of desmodium triquetrum, 15g of ligusticum wallichii, 18g of orthosiphon aristatus, 18g of paederia scandens, 9g of hypericum japonicum and 9g of immature bitter orange.
The preparation method of the millettia speciosa champ composition for protecting the liver comprises the following steps:
(1) taking beautiful millettia root, costus root, desmodium triquetrum, szechuan lovage rhizome, Chinese alpine rush, Chinese fevervine herb, hypericum japonicum thunb and immature bitter orange according to the formula amount, crushing, adding water with the weight 7 times of the total weight of medicinal materials for decocting, and filtering to remove medicinal residues to obtain filtrate; decocting for 3 times, and mixing filtrates;
(2) and concentrating the filtrate under reduced pressure to 35% of the total volume of the filtrate, controlling the temperature at 65 ℃ in the filtrate reduced pressure concentration process, adjusting the ethanol concentration to 95% of the volume concentration, standing for 14h, removing supernatant, and performing spray drying or freeze drying to obtain the beautiful millettia root composition.
The millettia speciosa champ composition for protecting the liver can be used for preparing a preparation with the effect of protecting the liver.
Example 6
A capsule for protecting liver is prepared by the following steps: taking the millettia speciosa champ composition for protecting the liver prepared in the embodiment, crushing the millettia speciosa champ composition, sieving the crushed millettia speciosa champ composition with a 70-mesh sieve, and adding 10 parts of cornstarch and 30 parts of cornstarch in parts by weight; mixing, and packaging to obtain the capsule.
Example 7
A liver protecting tablet is prepared by the following steps: taking the millettia speciosa champ composition for protecting the liver prepared in any embodiment, crushing, sieving with a 100-mesh sieve, adding 10 parts of the millettia speciosa champ composition, 20 parts of the powdered sugar and 1 part of the flavoring agent by weight, uniformly mixing, and tabletting to obtain the obtained tablets. Example 8
A granule for protecting liver is prepared by the following steps: taking the millettia speciosa champ composition for protecting the liver prepared in any one of the embodiments, crushing the millettia speciosa champ composition, sieving the millettia speciosa champ composition with a 100-mesh sieve, adding 10 parts of powdered sugar, 10 parts of maltodextrin and 0.1 part of flavoring agent in parts by weight; adding water, mixing to obtain soft material, and spray drying to obtain the granule.
The liver protecting composition has the effect of protecting the liver from carbon tetrachloride-induced liver injury
120 Kunming mice with the weight of 18-22g in each half of the male and female parts are divided into 10 groups, and the blank control group and the model group are respectively administered with 0.2mL/10g of physiological saline by intragastric administration and the positive control group is administered with 400mg/kg of bifendate according to the weight calculation of the mice. The administration group prepared the extract according to the following protocol and administered by gavage at a dose of 400 mg/kg. For 5 consecutive days. After 1h of the last administration, the other groups except the blank control group were injected with 0.1% vegetable oil solution of carbon tetrachloride in the abdominal cavity. The test method comprises the steps of fasting without water prohibition, removing eyeballs after 24 hours, taking blood, and measuring ALT (alanine aminotransferase) activity and AST (aspartate aminotransferase) activity by using a kit respectively. The results are shown in Table 1.
Experimental group 1: the beautiful millettia root composition for protecting liver prepared in example 1;
experimental group 2: the beautiful millettia root composition for protecting liver prepared in example 2;
experimental group 3: the beautiful millettia root composition for protecting liver prepared in example 3;
experimental group 4: the beautiful millettia root composition for protecting liver prepared in example 4;
experimental group 5: the beautiful millettia root composition for protecting liver prepared in example 5;
experimental group 6: the beautiful millettia root and the Chinese alpine rush are removed from the formula, and the rest operation is the same as the example 5;
experimental group 7: the components are removed of calabash tea, Chinese fevervine herb and hypericum japonicum, and the rest of the operation is the same as that in the embodiment 5;
experimental group 8: the formula is the same as the example 5 except that the bottle gourd white costustoot and the immature bitter orange are removed;
experimental group 9: the formula is the same as that in example 5 except that the rhizome of chuanxiong is removed.
TABLE 1 Effect of different treatments on carbon tetrachloride induced liver injury serum AST and ALT in mice
As can be seen from Table 1, the AST and ALT activities in the serum of the model group mice are obviously increased, which indicates that the modeling is successful. The activity of AST and ALT in the serum of the mice in the experimental group is reduced to different degrees, and the activity of AST and ALT in the experimental groups 1-5 is obviously lower than that in the experimental groups 6-9. The results show that the composition in 9 experimental groups can effectively inhibit the increase of AST and ALT activity in mice caused by carbon tetrachloride, and has different degrees of protective effects on acute liver injury of the mice. Meanwhile, the inhibition effect of the beautiful millettia root composition prepared by the 5 embodiments of the invention on the activity increase of AST and ALT is obviously higher than that of other experimental groups, which shows that the beautiful millettia root composition greatly enhances the liver protection effect by the combination and proportioning, and the effect is difficult to achieve by removing one or more components.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. The preparation method of the liver-protecting medicine is characterized in that the medicine is a water extraction and alcohol precipitation of the beautiful millettia root composition, and the beautiful millettia root composition comprises the following components in parts by weight: 10-50 parts of beautiful millettia root, 5-20 parts of aquilaria sinensis, 5-15 parts of desmodium triquetrum, 5-30 parts of ligusticum wallichii, 10-30 parts of felon paniculata, 10-30 parts of paederia scandens, 5-15 parts of hypericum japonicum and 5-15 parts of immature bitter orange; the preparation method comprises the following steps:
(1) decocting the beautiful millettia root composition with water, and filtering to remove dregs to obtain filtrate;
(2) concentrating the filtrate under reduced pressure, adding ethanol, adjusting the volume concentration of the ethanol to be 80-95%, standing, removing supernatant, and drying to obtain the beautiful millettia root composition.
2. The preparation method of the liver-protecting medicine according to claim 1, which comprises the following components in parts by weight: 20-30 parts of beautiful millettia root, 10-15 parts of aquilaria sinensis, 8-10 parts of desmodium triquetrum, 10-20 parts of ligusticum wallichii, 15-20 parts of orthosiphon aristatus, 15-20 parts of paederia scandens, 8-10 parts of hypericum japonicum and 8-10 parts of immature bitter orange.
3. The method for preparing the beautiful millettia root composition for protecting liver according to claim 1, which is characterized by comprising the following steps: in the step (1), the millettia speciosa champ is crushed before being decocted, the water adding amount is 5-8 times of the total weight of the medicinal materials, and the decoction is carried out for 3 times.
4. The method for preparing the beautiful millettia root composition for protecting liver according to claim 3, which is characterized by comprising the following steps: in the filtrate reduced pressure concentration process of the step (2), controlling the temperature to be 50-70 ℃, and concentrating to the volume of 30-50% of the original volume of the filtrate; standing for 12-20 h; the drying method is spray drying or freeze drying.
5. Use of the liver-protecting medicament prepared by the preparation method according to any one of claims 1-4 in the preparation of a preparation with liver-protecting effect.
6. A preparation for protecting liver is characterized in that: a liver-protecting medicine comprising the preparation method of any one of claims 1 to 4.
7. The liver-protecting formulation according to claim 6, wherein: the preparation is capsule, pill, tablet or granule.
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| CN105998386B true CN105998386B (en) | 2020-06-16 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103263604A (en) * | 2013-06-13 | 2013-08-28 | 刘庆 | Hundred-herb liver-nourishing tea and preparation method thereof |
| CN104435239A (en) * | 2014-12-15 | 2015-03-25 | 桂林医学院 | Traditional Chinese medicinal composition for preventing and treating hepatitis and preparation method of traditional Chinese medicinal composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263604A (en) * | 2013-06-13 | 2013-08-28 | 刘庆 | Hundred-herb liver-nourishing tea and preparation method thereof |
| CN104435239A (en) * | 2014-12-15 | 2015-03-25 | 桂林医学院 | Traditional Chinese medicinal composition for preventing and treating hepatitis and preparation method of traditional Chinese medicinal composition |
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