CN105997538A - Lycopene moistening and protecting chest film and preparation method thereof - Google Patents

Abstract

The invention discloses a lycopene moistening and protecting chest film and a preparation method thereof. The lycopene moistening and protecting chest film is mainly prepared from the following raw materials: 0.8 to 1.2 percent of lycopene, 9 to 13 percent of a humectant, 1.3 to 1.5 percent of an emulsifier, 0.08 to 0.15 percent of a thickener, 0.3 to 0.4 percent of a preservative, 0.02 to 0.07 percent of disodium EDTA and 0.1 to 0.3 percent of gellan gum, wherein the humectant is a mixture of sodium hyaluronate, betaine, butanediol and glycerin; the emulsifier is a mixture of glyceryl stearate/PEG-30 stearate, and steareth-10; the thickener is a mixture of xanthan gum, and acrylates/C10-30 alkanol acrylate cross-linked polymer; the preservative is a mixture of phenoxyethanol and methyl hydroxybenzoate. The lycopene moistening and protecting chest film adopts lycopene as a main effective component, has a good skin feeling, is capable of moisturizing and resisting senility, and has a certain prevention and treatment function on breast cancer.

Description

A kind of lycopene profit supports protection pleura and preparation method thereof

Technical field

The present invention relates to cosmetic field, particularly relate to a kind of lycopene profit support protection pleura and Its preparation method.

Background technology

Lycopene is a kind of natural pigment contained in plant.It is primarily present in plant of Solanaceae west In the mature fruit of red Fructus Kaki.It is the strong anti-oxidation being found in the plant of nature at present One of agent.Science proves, singlet oxygen and oxygen-derived free radicals in human body are that infringement human body self is exempted from The arch-criminal of epidemic disease system.Lycopene is removed effect of free radical and is outclassed other carotenoids Element and vitamin E, its singlet-oxygen quenching speed constant is 100 times of vitamin E.Freely Base and active oxygen are the by-products during body metabolism, and they can be anti-with intracellular macromolecules Should, destroy cell and the integrity of tissue.It can be with effectively preventing because of aging, immunity Power declines the various diseases caused.

The researcher of the Rutgers university (Rutgers University) being positioned at New Jersey is carried out One test, arranges 70 breast carcinoma high-risk women of more than 55 years old (obesity or straight It is relatives to have people suffer from breast carcinoma) improve 10 week of Fructus Lycopersici esculenti amount, survey respectively before and after experiment Measure its internal hormone quantity.It was found that the lycopene that one glass of Fructus Lycopersici esculenti juice brings, can To make the adiponectin secretion raising 9% in women body.Adiponectin is that one contributes to health regulation The hormone of fat level, this hormone-content in lean person's body is the highest, and obesity is then The risk that breast carcinoma is ill can be improved.

" a kind of chest protector quintessence oil stock solution and the biological magnetic chest protector film of sensing and their preparation method " (application publication number: CN104840383A), discloses a kind of biological magnetic chest protector spraying quintessence oil Film, it is possible to desalinate mammary areola, compact skin, but need to be sprayed on pleura by quintessence oil just when using Can use, process is relatively complicated.

To this end, the invention discloses a kind of lycopene profit to support protection pleura, easy to use, Breast carcinoma can also there be is preventive effect while there is whitening and softening skin function.

Summary of the invention

In order to overcome the defect of prior art, the invention discloses a kind of lycopene profit and support protection Pleura, easy to use, while there is whitening and softening skin function, breast carcinoma can also there be is prevention Effect.

The present invention is achieved through the following technical solutions:

A kind of lycopene profit supports protection pleura, and described pleura includes the former of following percentage by weight Material: lycopene 0.8～1.2%, wetting agent 9～13%, emulsifying agent 1.3～1.5%, thickening agent 0.08～0.15%, preservative 0.3～0.4%, EDETATE SODIUM 0.02～0.07%, gellan gum 0.1～0.3%.

Further, described pleura also include biological carbohydrate gum-12.1～2.8%, glycyrrhizic acid dipotassium 0.12～0.18%, 2-Methylpentadecane 1.5～2.5%, triethanolamine 0.02～0.06%, calcium chloride 0.03～0.07%.

Further, wetting agent described in pleura of the present invention is hyaluronate sodium, glycine betaine, fourth Glycol, the mixture of glycerol；Described emulsifying agent be glyceryl stearate/PEG-30 stearate, The mixture of stereth-10；Described thickening agent is xanthan gum, acrylic acid (ester) class The mixture of/C10-30 alkylol acrylamide acid esters cross linked polymer；Described preservative be phenoxyethanol, The mixture of methyl hydroxybenzoate.

The preparation method of above-mentioned pleura mainly comprises the steps that

1) by butanediol, glycerol, glycine betaine, EDETATE SODIUM, xanthan gum, gellan gum, Methyl hydroxybenzoate, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, go from Sub-water as A be added in aqueous phase pot stirring be warming up to 80-85 DEG C standby；

2) using glyceryl stearate/PEG-30 stearate, stereth-10 as B phase Add stirring in oil phase pot be warming up to 80-85 DEG C standby；

3) by B phase suction A phase, homogenizing 10 minutes, it is incubated 80 DEG C and stirs 30 minutes；

4) adding in 2-Methylpentadecane by lycopene, stirring is warming up to 50-55 DEG C.Treat tomato red Element is completely dissolved, standby；

5) after temperature is down to 55 DEG C, the lycopene dissolved is added in aqueous phase pot, stirs Mix uniformly；

6) triethanolamine regulation PH is added；

7), after temperature is down to 40 DEG C, biological carbohydrate gum-1, glycyrrhizic acid dipotassium, calcium chloride are added, Stir；

8) adding phenoxyethanol, stir discharging.

Lycopene, is a kind of natural pigment contained in plant.It is primarily present in plant of Solanaceae In the mature fruit of Fructus Lycopersici esculenti.It is the strongest antioxygen being found in the plant of nature at present One of agent.Science proves, singlet oxygen and oxygen-derived free radicals in human body are infringement human bodies self Immune arch-criminal.Lycopene is removed effect of free radical and is outclassed other classes trailing plants recklessly Bu Su and Herba Centellae, its singlet-oxygen quenching speed constant is 100 times of Herba Centellae.It is permissible Effectively preventing because of aging, the various diseases that immunity degradation causes, ultra-violet radiation resisting function: Lycopene can be to ultraviolet injury resistant.Research worker gives each supplementary 28 milligrams of 10 Healthy Peoples Beta-carotene and 2 milligrams of lycopene 1-2 month, result takes lycopene crowd's ultraviolet Line causes the area of erythema to reduce, and degree alleviates, slow down aging, enhancing immunity: tomato red Element can remove the free radical in human body most effectively, keeps cell homergy, pre-anti-aging. Lycopene is absorbed into blood and lymph by gastrointestinal mucosal in vivo, be distributed to testis, Adrenal gland, prostate, pancreas, breast, ovary, liver, lung, colon, skin and various Mucosal tissue, promotes glandular secretion hormone, so that human body keeps vigorous energy；Remove this Free radical in a little organs and tissue, protects them from injury, enhancing human body immunity power.Print Degree scholar points out, lycopene can make Infertil man sperm quantity increase, vigor strengthens, thus Cure sterile problem.Lycopene can be substantially improved skin allergy, eliminates because of skin allergy The xerosis cutis caused and convulsion gargalesthesia, make us feeling relaxed happy.

Described lycopene is with black tomato lyophilized powder for extracting raw material, using 2-Methylpentadecane as extraction Solvent, uses low-temperature ultrasonic extracting method to carry out, then can obtain Fructus Lycopersici esculenti by simple filtration Red pigment, is directly appended to pleura product, simple.

Described black tomato lyophilized powder with black tomato as raw material, vacuum under the cryogenic conditions of-50 DEG C Pulverize, obtain black tomato lyophilized powder.Content of lycopene in black tomato is 74.8mg/kg, Being more than 3 times of Lycopersicon esculentum, the content of lycopene in the black tomato lyophilized powder made then reaches Arrive the height of 818mg/kg.The present invention uses black tomato lyophilized powder to be to extract raw material, can be The increase extraction ratio of degree, and the protection to lycopene greatly has reached optimum.

Described 2-Methylpentadecane is non-polar solven, good with the lycopene compatibility, intermolecular interaction Power is big, and extraction efficiency is high, is particularly suitable for as the solvent extracting lycopene；Further, different ten Six alkane skinfeels are salubrious, graceful, and spreadability is good, it is possible to form one layer of barrier on skin, stop Scattering and disappearing of moisture, moisture retention is good.

Film patch series products is usually water preparation formula, but in view of lycopene to be added is oil-soluble Composition, i.e. formula must have the addition of oil, it is considered to the most low viscous emulsion is as pleura product Type.First, select to be suitable for making low viscosity emulsion or the emulsifying agent of sprayable emulsion.Glycerol Stearate, PEG-30 stearate and stereth-10 are highly suitable for making low gluing Emulsion.Secondly, low viscosity emulsion intercalation method is again a major challenge.For the water that viscosity is relatively low Bag fat liquor, in the case of long-time placement, oils and fats easily floats, and causes emulsion unstable, Here consider that adding a kind of suspension stabilizer stablizes emulsion.Gellan gum, possesses preferably oils and fats Suspending stabilized effect, under the conditions of centrifugal 3000r/min, 30min, low slimy milk liquid is not sent out The wild effects such as layer floating estranged, therefore, use gellan gum to strengthen the stability of product.

Add moisturizing ingredient hyaluronate sodium, glycine betaine, butanediol, glycerol etc., skin care, anti- Declining ingredients Biogenic carbohydrate gum-1, antiallergic composition glycyrrhizic acid dipotassium, to the good skinfeel body of skin one Test.

Having the beneficial effects that of pleura of the present invention:

1) present invention extraction raw material with black tomato lyophilized powder as lycopene, with other raw materials Compare, extract process simple and effective, can farthest increase extraction ratio, and to tomato red The protection of element has reached optimum, it is possible to farthest maintain the functional characteristic of lycopene；

2) lycopene is added in pleura, utilizes the characteristic of its antioxidation, defying age, Play the preventive and therapeutic effect to breast carcinoma；

3) with the addition of the biological functional component such as carbohydrate gum-1, glycyrrhizic acid dipotassium, skin care antiallergic.

Detailed description of the invention:

Preparation method:

1) by butanediol, glycerol, glycine betaine, EDETATE SODIUM, xanthan gum, gellan gum, Methyl hydroxybenzoate, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, go from Sub-water as A be added in aqueous phase pot stirring be warming up to 80-85 DEG C standby；

2) using glyceryl stearate/PEG-30 stearate, stereth-10 as B phase Add stirring in oil phase pot be warming up to 80-85 DEG C standby；

3) by B phase suction A phase, homogenizing 10 minutes, it is incubated 80 DEG C and stirs 30 minutes；

4) adding in 2-Methylpentadecane by lycopene, stirring is warming up to 50-55 DEG C.Treat tomato red Element is completely dissolved, standby；

5) after temperature is down to 55 DEG C, the lycopene dissolved is added in aqueous phase pot, stirs Mix uniformly；

6) appropriate triethanolamine regulation PH is added；

7), after temperature is down to 40 DEG C, biological carbohydrate gum-1, glycyrrhizic acid dipotassium, calcium chloride are added, Stir；

8) add phenoxyethanol, stir discharging in 30 minutes.

Embodiment 1

Butanediol: 2%

Glycerol: 2%

Glycine betaine: 1.8%

Biological carbohydrate gum-1:1.9%

2-Methylpentadecane: 1%

Hyaluronate sodium: 0.04%

Lycopene: 0.8%

Glyceryl stearate/PEG-30 stearate: 0.5%

Stereth-10:0.4%

EDETATE SODIUM: 0.02%

Xanthan gum: 0.06%

Gellan gum: 0.1%

Methyl hydroxybenzoate: 0.08%

Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer: 0.02%

Triethanolamine: 0.02%

Glycyrrhizic acid dipotassium: 0.11%

Calcium chloride: 0.02%

Phenoxyethanol: 0.15%

Deionized water: surplus

Embodiment 2

Butanediol: 7%

Glycerol: 5%

Glycine betaine: 3.2%

Biological carbohydrate gum-1:3.1%

2-Methylpentadecane: 4%

Hyaluronate sodium: 0.1%

Lycopene: 1.2%

Glyceryl stearate；PEG-30 stearate: 1.0%

Stereth-10:1.1%

EDETATE SODIUM: 0.08%

Xanthan gum: 0.12%

Gellan gum: 0.4%

Methyl hydroxybenzoate: 0.2%

Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer: 0.08%

Triethanolamine: 0.08%

Glycyrrhizic acid dipotassium: 0.19%

Calcium chloride: 0.08%

Phenoxyethanol: 0.32%

Deionized water: surplus

Embodiment 3

Butanediol: 5%

Glycerol: 3%

Glycine betaine: 2.5%

Biological carbohydrate gum-1:2.5%

2-Methylpentadecane: 2%

Hyaluronate sodium: 0.07%

Lycopene: 1%

Glyceryl stearate；PEG-30 stearate: 0.7%

Stereth-10:0.6%

EDETATE SODIUM: 0.05%

Xanthan gum: 0.08%

Gellan gum: 0.2%

Methyl hydroxybenzoate: 0.1%

Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer: 0.04%

Triethanolamine: 0.04%

Glycyrrhizic acid dipotassium: 0.15%

Calcium chloride: 0.05%

Phenoxyethanol: 0.25%

Deionized water: surplus

Experimentation

Randomly select 25 female volunteers, the pleura of the application present invention after taking a shower every night 15-20 minute, use 3 months continuously, observe using effect.

Using effect data see table:

Chest substantially moistens	23
		Chest skin compacts, flexible	23
Without significant change	0

After Shi Yong, all do not find zest and allergic phenomena.

As seen from the table, after being suitable for the product of the present invention, trier's chest skin has obtained well Improvement.

Embodiment described above only have expressed the several embodiments of the present invention, and its description more has Body is with detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.Should refer to Go out, for the person of ordinary skill of the art, before without departing from present inventive concept Putting, it is also possible to make some deformation and improvement, these broadly fall into protection scope of the present invention.

Claims (5)

1. a lycopene profit supports protection pleura, it is characterised in that described pleura mainly includes The component of following percent by weight: lycopene 0.8～1.2%, wetting agent 9～13%, emulsifying Agent 1.3～1.5%, thickening agent 0.08～0.15%, preservative 0.2～0.4%, EDETATE SODIUM 0.02～0.07%, gellan gum 0.1～0.3%.

A kind of lycopene profit the most according to claim 1 supports protection pleura, and its feature exists In, also include biological carbohydrate gum-12.1～2.8%, glycyrrhizic acid dipotassium 0.12～0.18%, 2-Methylpentadecane 1.5～2.5%, triethanolamine 0.02～0.06%, calcium chloride 0.03～0.07%.

A kind of lycopene profit the most according to claim 1 and 2 supports protection pleura, and it is special Levying and be, described wetting agent is the mixture of hyaluronate sodium, glycine betaine, butanediol, glycerol； Described emulsifying agent be glyceryl stearate/PEG-30 stearate, stereth-10 mixed Compound；Described thickening agent is xanthan gum, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters The mixture of cross linked polymer；Described preservative is the mixture of phenoxyethanol, methyl hydroxybenzoate.

A kind of lycopene profit the most according to claim 1 and 2 supports protection pleura, and it is special Levying and be, described lycopene is made up of the extraction of black tomato lyophilized powder cryogenic vacuum.

5. a kind of lycopene profit as described in any one of claim 1-4 supports the system of protection pleura Preparation Method, it is characterised in that comprise the following steps:

1) by butanediol, glycerol, glycine betaine, EDETATE SODIUM, xanthan gum, gellan gum, Methyl hydroxybenzoate, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, go from Sub-water as A be added in aqueous phase pot stirring be warming up to 80-85 DEG C standby；

2) using glyceryl stearate/PEG-30 stearate, stereth-10 as B phase Add stirring in oil phase pot be warming up to 80-85 DEG C standby；

3) by B phase suction A phase, homogenizing 10 minutes, it is incubated 80 DEG C and stirs 30 minutes；

4) adding in 2-Methylpentadecane by lycopene, stirring is warming up to 50-55 DEG C, treats tomato red Element is completely dissolved, standby；

5) after temperature is down to 55 DEG C, the lycopene dissolved is added in aqueous phase pot, stirs Mix uniformly；

6) triethanolamine regulation PH is added；

7), after temperature is down to 40 DEG C, biological carbohydrate gum-1, glycyrrhizic acid dipotassium, calcium chloride are added, Stir；

8) adding phenoxyethanol, stir discharging.