CN105963490A - Pharmaceutical composition used for preventing and treating heat stress of aquatic livestock and preparation method thereof - Google Patents
Pharmaceutical composition used for preventing and treating heat stress of aquatic livestock and preparation method thereof Download PDFInfo
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- CN105963490A CN105963490A CN201510686319.9A CN201510686319A CN105963490A CN 105963490 A CN105963490 A CN 105963490A CN 201510686319 A CN201510686319 A CN 201510686319A CN 105963490 A CN105963490 A CN 105963490A
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Abstract
The invention discloses a pharmaceutical composition used for preventing and treating heat stress of aquatic livestock and a preparation method thereof. The pharmaceutical composition comprises the following raw materials in parts by weight: 10-20 parts of dandelion, 5-15 parts of root of kudzu vine, 5-15 parts of raw rehmannia, 1-5 parts of radix astragali, 5-15 parts of capillary Artemisia, 1-5 parts of mile swertia herb, 5-15 parts of fructus teminaliae billaricae, 5-15 parts of euphorbiae humifusae herb, 10-20 parts of herba andrographitis, 1-5 parts of anemarrhena, 1-5 parts of hawthorn, 5-15 parts of rabdosia lophanthide, 1-5 parts of mile swertia herb, 1-5 parts of rheum officinale, and 5-15 parts of phellodendron; and then 1.5 parts of Vc is added in the extract product through extraction, concentration and drying to prepare the pharmaceutical composition. The pharmaceutical composition has the functions of clearing heat and detoxicating, protecting liver and benefiting gallbladder, appetizing and invigorating spleen, and increasing immunity, and can effectively prevent and treat heat stress of aquatic livestock.
Description
Technical field
The present invention relates to a kind of prevent and treat aquatic animal stress pharmaceutical composition and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Stress be the general nonspecific reaction that occurred when various internal and external environment factors stimulate of body, be also called stress.Raising now with intensive culture degree, the deterioration of breeding environment, aquatic animal is being faced with more and more stress, principal element is that dead sample density is excessive, water pollution, abrupt change of climate, medicine irritation, transport for long-distance, draw in the net stress, feed nutrition improper etc., light then affect the growth promoter of Fish, heavy then cause the death of Fish.
Summary of the invention
It is an object of the invention to, it is provided that a kind of prevent and treat aquatic animal stress pharmaceutical composition and preparation method thereof, it is possible to significantly improve the anti-stress ability of aquatic animal.
The present invention is achieved by the following technical solutions:
A kind of prevent and treat aquatic animal stress pharmaceutical composition and preparation method thereof be prepared from by the raw material of following parts by weight: Herba Taraxaci 10-20 part, Radix Puerariae 5-15 part, Radix Rehmanniae 5-15 part, Radix Astragali 1-5 part, Herba Artemisiae Scopariae 5-15 part, Herba Swertiae Mileensis 1-5 part, Fructus Terminaliae Billericae 5-15 part, Herba Euphorbiae Humifusae 5-15 part, Herba Andrographis 10-20 part, Rhizoma Anemarrhenae 1-5 part, Fructus Crataegi 1-5 part, Herba Rabdosiae Lophanthoidis 5-15 part, Herba Swertiae Mileensis 1-5 part, Radix Et Rhizoma Rhei 1-5 part, Cortex Phellodendri 5-15 part, Vc1-5 part.
Preferably, a kind of pharmaceutical composition preventing and treating aquatic animal heat stress, it is made up of the raw material of following parts by weight:
Herba Taraxaci 15 parts, Radix Puerariae 10 parts, Radix Rehmanniae 10 parts, the Radix Astragali 3 parts, Herba Artemisiae Scopariae 10 parts, Herba Swertiae Mileensis 3 parts, Fructus Terminaliae Billericae 10 parts, Herba Euphorbiae Humifusae 10 parts, Herba Andrographis 15 parts, the Rhizoma Anemarrhenae 3 parts, Fructus Crataegi 3 parts, Herba Rabdosiae Lophanthoidis 10 parts, Herba Swertiae Mileensis 3 parts, Radix Et Rhizoma Rhei 3 parts, Cortex Phellodendri 10 parts, Vc3 part.
Preventing and treating aquatic animal stress the preparation method of pharmaceutical composition as follows:
(1) choose above-mentioned Chinese crude drug, at 50-60 DEG C, dry 2-3h, be respectively crushed into coarse powder, weigh.
(2) above-mentioned coarse powder is added water extraction 1-4 time of 4-12 times amount, each 1-5h, heat filtering after extraction, concentrates, dry to obtain extract.
(3) one or more adjuvants that said extracted thing adds in Vc and powdered rice hulls, silicon dioxide, sucrose, dextrin are made product.
Beneficial effects of the present invention:
1, the present invention has heat-clearing and toxic substances removing, hepatic cholagogic, blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis, effect of appetite promoting and the spleen strengthening, thus have alleviation aquatic animal stress, improve the resistance against diseases of aquatic animal.
2, the present invention has natural, and no drug residue has no side effect, it is possible to meet people's requirement for food safety.
Detailed description of the invention
Preventing and treating aquatic animal stress pharmaceutical composition, the raw material of following parts by weight be prepared from: Herba Taraxaci 15 parts, Radix Puerariae 10 parts, Radix Rehmanniae 10 parts, the Radix Astragali 3 parts, Herba Artemisiae Scopariae 10 parts, Herba Swertiae Mileensis 3 parts, Fructus Terminaliae Billericae 10 parts, Herba Euphorbiae Humifusae 10 parts, Herba Andrographis 15 parts, the Rhizoma Anemarrhenae 3 parts, Fructus Crataegi 3 parts, Herba Rabdosiae Lophanthoidis 10 parts, Herba Swertiae Mileensis 3 parts, Radix Et Rhizoma Rhei 3 parts, Cortex Phellodendri 10 parts, Vc3 part.
Preventing and treating aquatic animal stress pharmaceutical composition, preparation method is as follows:
(1) choose above-mentioned Chinese crude drug, at 60 DEG C, dry 3h, be respectively crushed into coarse powder, weigh.
(2) above-mentioned coarse powder is added the water extraction 3 times of 8 times amount, each 4h, heat filtering after extraction, concentrates, be dried and to obtain extract.
(3) said extracted thing is added Vc and product made by powdered rice hulls, silicon dioxide adjuvant.
Test example
The present invention impact on rolling into a ball head fish growth performance in the case of heat stress
1.1 material
1.1.1 experimental animal: Megalobrama amblycephala, original body mass is at 120.56 ± 1.21g
1.1.2 test material: the embodiment of the present invention, Vc
1.2 test method
1.2.1 packet is tested
Choosing Megalobrama amblycephala 900 tail physically fit, the Megalobrama amblycephala kind that specification is consistent, original body mass, at 120.56 ± 1.21g, is randomly divided into 3 groups, and often group 300, is set to blank group, Vc group, embodiment of the present invention group.
1.2.2 feeding and management
Choosing the pond that specification is the same, 300 tail fishes are put in every pond in a suitable place to breed.Megalobrama amblycephala basal diet is thrown something and fed after feeding 15 days test daily ration.Throwing something and feeding every day twice, water source is subsoil water, and cultivation pool inner water is changed weekly once, changes water 1/3 every time, absorbs sewage once, day and night continuous charge oxygen supplement every time.During raising, water temperature controls at 24 DEG C-28 DEG C, and pH value is 6.8-7.6, and dissolved oxygen is more than 5mg/L, and ammonia nitrogen is less than 0.05mg/L, and breeding cycle is 75 days, and containing domestication 15 days, the formal test time was 60 days.Cultivation carries out statistical analysis to test data after terminating.
1.2.3 growth and body testing index
It is calculated as follows rate of body weight gain (weight gain rate respectively, WGR), feed coefficient (feed coefficient, FC), mortality rate (mortality, M), liver body ratio (hepatosomatic index, HSI), internal organs ratio (viscerosomatic index, VSI), coefficient of condition (condition factory, CF):
Rate of body weight gain (WGR, %)=100* (Wt-W0)/W0
Feed coefficient (FC)=FI (Wt-W0)
Mortality rate (M, %)=100 (NO-Nt)/N0
Liver body ratio (HIS, %)=100*Wh/Wb
Internal organs ratio (VSI, %)=100*Wv/Wb
Coefficient of condition (CF, %)=100*Wb/L3
In formula, W0 (g) is fish just body weight counterpoise；Wt (g) is fish opisthosoma counterpoise；T (d) is for feeding natural law；The every tail fish of FI (g) averagely ingests feedstuff total amount (air-drying sample weight)；N0 is first fish tail number；Nt end fish tail number；Wh (g) is every tail fish end liver weight；Wv (g) is every tail fish end internal organs weight；Wb (g) is every tail fish opisthosoma weight；L (cm) is that every tail fish opisthosoma is the longest.
1.3 result of the test
Table 1 present invention impact on Megalobrama amblycephala growth performance
| Project | Matched group | Vc group | Of the present invention group |
| Just body weight (g) | 121.32±1.11 | 119.89±1.24 | 120.47±0.99 |
| Opisthosoma weight (g) | 213.21±2.32 | 226.25±2.21 | 231.34±1.68 |
| Rate of body weight gain (%) | 75.74±1.03 | 88.71±1.32 | 92.03±2.01 |
| Feed coefficient | 2.32±0.03 | 2.10±0.06 | 1.88±0.02 |
| Mortality rate | 4.21±0.63 | 1.86±0.21 | 0.81±0.13 |
As known from Table 1, compared with blank group, rate of body weight gain and the specific growth rate of of the present invention group and Vc group Megalobrama amblycephala are all significantly increased, wherein rate of body weight gain has been respectively increased 13.04%, 18.13%, feed coefficient has all declined than matched group, mortality rate reduces substantially, and of the present invention group of each index is superior to Vc group.
Claims (4)
- null1. pharmaceutical composition preventing and treating aquatic animal heat stress and preparation method thereof，It is characterized in that，By Herba Taraxaci (Taraxacum mongolicum Hand.-Mazz.、Taraxacum borealisinense Kitam.)、Radix Puerariae (Pueraria lobata (Willd.) Ohwi)、Radix Rehmanniae (Rehmannia glutinosa Libosch.)、The Radix Astragali (Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao、Astragalus membranaceus(Fisch.)Bge.)、Herba Artemisiae Scopariae (Artemisia scoparia Waldst.et Kit.、Artemisia capillaris Thunb.)、Herba Swertiae Mileensis (Swertia mileensis T.N.Ho et W.L.Shih)、Fructus Terminaliae Billericae (Terminalia bellirica (Gaertn.) Roxb.)、Herba Euphorbiae Humifusae (Euphorbia humifusa willd.、Euphorbia maculata L.)、Herba Andrographis (Andrographis paniculata (Burm.f.) Nees)、Fructus Crataegi (Crataegus pinnatifida Bge.var.major N.E.Br.)、Herba Rabdosiae Lophanthoidis (Rabdosia serra (Maxim.) Hara)、Herba Swertiae Mileensis (Swertia mileensis T.N.Ho et W.L.Shih)、Radix Et Rhizoma Rhei (Rheum palmatum L.、Rheum tanguticum Maxim.ex B、Rheum offcihale Baill.)、Cortex Phellodendri (Phellodendron chinense Schneid.)、Vc raw material is prepared from.
- The most according to claim 1 a kind of prevent and treat aquatic animal stress pharmaceutical composition, it is characterized in that, the raw material of following parts by weight be prepared from: Herba Taraxaci 12-18 part, Radix Puerariae 8-12 part, Radix Rehmanniae 8-12 part, Radix Astragali 2-4 part, Herba Artemisiae Scopariae 8-12 part, Herba Swertiae Mileensis 2-4 part, Fructus Terminaliae Billericae 8-12 part, Herba Euphorbiae Humifusae 8-12 part, Herba Andrographis 12-18 part, Rhizoma Anemarrhenae 2-4 part, Fructus Crataegi 2-4 part, Herba Rabdosiae Lophanthoidis 8-12 part, Herba Swertiae Mileensis 2-4 part, Radix Et Rhizoma Rhei 2-4 part, Cortex Phellodendri 8-12 part, Vc 1-5 part.
- 3. according to a kind of described in claim 1-2 prevent and treat aquatic animal stress pharmaceutical composition, it is characterized in that, the raw material of following parts by weight be prepared from: Herba Taraxaci 15 parts, Radix Puerariae 10 parts, Radix Rehmanniae 10 parts, the Radix Astragali 3 parts, Herba Artemisiae Scopariae 10 parts, Herba Swertiae Mileensis 3 parts, Fructus Terminaliae Billericae 10 parts, Herba Euphorbiae Humifusae 10 parts, Herba Andrographis 15 parts, the Rhizoma Anemarrhenae 3 parts, Fructus Crataegi 3 parts, Herba Rabdosiae Lophanthoidis 10 parts, Herba Swertiae Mileensis 3 parts, Radix Et Rhizoma Rhei 3 parts, Cortex Phellodendri 10 parts, Vc 3 parts.
- 4. pharmaceutical composition preventing and treating aquatic animal heat stress and preparation method thereof is as follows:(1) choose above-mentioned Chinese crude drug, at 50-60 DEG C, dry 2-3h, be respectively crushed into coarse powder, weigh.(2) above-mentioned coarse powder is added water extraction 1-4 time of 4-12 times amount, each 1-5h, heat filtering after extraction, concentrates, dry to obtain extract.One or more adjuvants that said extracted thing adds in Vc and powdered rice hulls, silicon dioxide, sucrose, dextrin are made product.
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| CN201510686319.9A CN105963490B (en) | 2015-10-21 | 2015-10-21 | A kind of pharmaceutical composition and preparation method thereof preventing and treating aquatic livestock heat stress |
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| CN201510686319.9A CN105963490B (en) | 2015-10-21 | 2015-10-21 | A kind of pharmaceutical composition and preparation method thereof preventing and treating aquatic livestock heat stress |
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| CN105963490A true CN105963490A (en) | 2016-09-28 |
| CN105963490B CN105963490B (en) | 2019-10-29 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524117A (en) * | 2009-04-21 | 2009-09-09 | 陆晓巍 | Plant medicine granule serving as feed additive for preventing and treating poultry and livestock diseases and preparation thereof |
| CN101961462A (en) * | 2010-10-20 | 2011-02-02 | 江苏经贸职业技术学院 | Chinese medicinal composition for resisting heat stress of pigeons and application thereof |
| CN102552411A (en) * | 2012-03-15 | 2012-07-11 | 中国水产科学研究院黑龙江水产研究所 | Chinese herbal medicine immunopotentiator for sturgeon fingerling |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524117A (en) * | 2009-04-21 | 2009-09-09 | 陆晓巍 | Plant medicine granule serving as feed additive for preventing and treating poultry and livestock diseases and preparation thereof |
| CN101961462A (en) * | 2010-10-20 | 2011-02-02 | 江苏经贸职业技术学院 | Chinese medicinal composition for resisting heat stress of pigeons and application thereof |
| CN102552411A (en) * | 2012-03-15 | 2012-07-11 | 中国水产科学研究院黑龙江水产研究所 | Chinese herbal medicine immunopotentiator for sturgeon fingerling |
Non-Patent Citations (2)
| Title |
|---|
| 李松龄等: "《兽牡兽医实用新技术》", 31 March 2009, 中原出版传媒集团等 * |
| 陆文永等: "中草药在水产养殖中的实际应用", 《北京水产》 * |
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