CN105963292B - 一种用于心肌梗死治疗的药物组合物及其应用 - Google Patents
一种用于心肌梗死治疗的药物组合物及其应用 Download PDFInfo
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- CN105963292B CN105963292B CN201610401454.9A CN201610401454A CN105963292B CN 105963292 B CN105963292 B CN 105963292B CN 201610401454 A CN201610401454 A CN 201610401454A CN 105963292 B CN105963292 B CN 105963292B
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- sotalol
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- 229960002370 sotalol Drugs 0.000 claims abstract description 36
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 claims abstract description 26
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
黄芩苷元 | 1g |
索他洛尔 | 10g |
微晶纤维素 | 45g |
淀粉 | 30g |
15%淀粉浆 | 适量 |
硬脂酸镁 | 2.0g |
黄芩苷元 | 10g |
索他洛尔 | 1g |
可压性淀粉 | 90g |
乳糖 | 50g |
15%淀粉浆 | 适量 |
微粉硅胶 | 1.5g |
黄芩苷元 | 10g |
索他洛尔 | 2g |
交联羧甲基纤维素钠 | 12g |
微晶纤维素 | 160g |
聚乙烯吡咯烷酮 | 6g |
5%PVP 60%乙醇溶液 | 适量 |
微粉硅胶 | 5g |
黄芩苷元 | 50g |
索他洛尔 | 5g |
可压性淀粉 | 90g |
乳糖 | 50g |
15%淀粉浆 | 适量 |
微粉硅胶 | 1.5g |
黄芩苷元 | 40g |
索他洛尔 | 8g |
淀粉 | 180g |
糊精 | 50g |
蔗糖粉 | 60g |
80%乙醇 | 适量 |
黄芩苷元 | 50g |
索他洛尔 | 50g |
淀粉 | 180g |
糊精 | 50g |
蔗糖粉 | 60g |
80%乙醇 | 适量 |
组别 | n | CK(U/L) | AST(U/L) | LDH(U/L) |
对照组 | 12 | 365±38 | 54±11 | 324±35 |
模型组 | 12 | 1348±262 | 231±44 | 1454±331 |
索他洛尔低组 | 12 | 953±58* | 168±13* | 1018±121* |
索他洛尔高组 | 12 | 873±64* | 158±16* | 914±142* |
黄芩苷元低组 | 12 | 1025±95 | 202±12 | 1207±112 |
黄芩苷元高组 | 12 | 986±63* | 195±11* | 1106±95* |
复方1组 | 12 | 658±84**#▼ | 124±29**#▼ | 859±117**#▼ |
复方2组 | 12 | 549±67**#▼▼ | 86±18**##▼▼ | 734±115**##▼▼ |
复方3组 | 12 | 437±57**##▼▼ | 68±14**##▼▼ | 610±98**##▼▼ |
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610401454.9A CN105963292B (zh) | 2016-06-10 | 2016-06-10 | 一种用于心肌梗死治疗的药物组合物及其应用 |
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Application Number | Priority Date | Filing Date | Title |
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CN201610401454.9A CN105963292B (zh) | 2016-06-10 | 2016-06-10 | 一种用于心肌梗死治疗的药物组合物及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN105963292A CN105963292A (zh) | 2016-09-28 |
CN105963292B true CN105963292B (zh) | 2018-11-09 |
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CN201610401454.9A Active CN105963292B (zh) | 2016-06-10 | 2016-06-10 | 一种用于心肌梗死治疗的药物组合物及其应用 |
Country Status (1)
Country | Link |
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CN (1) | CN105963292B (zh) |
Citations (1)
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