CN1059338A - The preparation of cantharidia liposoluble pharmaceutics - Google Patents
The preparation of cantharidia liposoluble pharmaceutics Download PDFInfo
- Publication number
- CN1059338A CN1059338A CN90106365A CN90106365A CN1059338A CN 1059338 A CN1059338 A CN 1059338A CN 90106365 A CN90106365 A CN 90106365A CN 90106365 A CN90106365 A CN 90106365A CN 1059338 A CN1059338 A CN 1059338A
- Authority
- CN
- China
- Prior art keywords
- cantharidin
- preparation
- fat
- soluble
- mylabris
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of fat-soluble Cantharidin intermediate preparation, and utilize the preparation method of prepared intermediate preparation for the serial antiviral antibiotic new preparation of effective ingredient, its fat-soluble Cantharidin intermediate preparation to adopt suitable solvent temperature and utilize Oleum Mylabris to increase the solubleness of Cantharidin and the special process method of steady dissolution.The clinical treatment of prepared new drug shows that medicament that this class contains fat-soluble Cantharidin is the specifics of virus infectiones such as treatment viral hepatitis.This fat-soluble Cantharidin intermediate preparation of this external application also can be prepared the cantharidia liposoluble pharmaceutics of local external use's drug effect of a series of treatment virus infectiones.
Description
The invention belongs to the preparation method of medicine, specifically, Cantharidin and Oleum Mylabris are made fat-soluble intermediate preparation, again intermediate preparation is prepared into various fat-soluble Cantharidin anti-virus formulations by extracting Cantharidin and Oleum Mylabris in the insect Chinese blister beetle body.
Cantharidin is by what extract in the insect Chinese blister beetle body the hypertoxicity material to be arranged.Cantharis medically has the record of antitumor action very early as medicine in China.External classic Chinese blister beetle plaster is to be aided with beeswax, rosin, tallow, the made vesicatory of turpentine wet goods by powder of cantharide, powder of cantharide accounts for 25% in this cream, do not have through Calculation of Solubility and experimental observation Cantharidin major part in system cream process dissolved, so this classic dermerethistica finished product that are powder of cantharide.In recent years, found particularly that Cantharidin can be used as after the anticarcinogen, the pharmacology of Cantharidin and the research of using on clinical medicine had been developed by leaps and bounds.The method that at present prepares Cantharidin and adopted is to utilize organic solvent, for example extracting from powder of cantharide such as acetone, chloroform.Increase yield for impelling MAGNESIUM CANTHARIDATE to change into Cantharidin, so usually before, all will handle powder of cantharide with concentrated hydrochloric acid with organic solvent extracting Cantharidin.And contain the preparation of Cantharidin, also be non-liposoluble preparation, for example, Cantharidin sheet (Shanghai Q/WS-1-566-80) and Cantharidin injection liquid (Shanghai Q/WS-1-567-80).
In recent years find again medically that Cantharidin is a kind of antiviral antibiotic, but Cantharidin is also not obvious in the common non-fat-soluble Cantharidin preparation reaction of the intravital this antibiosis drug effect of humans and animals, and fat-soluble Cantharidin demonstrates good effect (Nature Journal was rolled up 458 pages of 6 phases in 1980 3).Particularly, utilize fat-soluble Cantharidin prepared preparation can play the specific effect to the treatment of virus infectiones such as viral hepatitis.But as the serial antiviral that preparation and this class of modern Western medicine cantharidia liposoluble pharmaceutics contains cantharidia liposoluble pharmaceutics still find no report.
The purpose of this invention is to provide the method for preparing the fat-soluble intermediate preparation of Cantharidin and utilize the basic raw material of prepared this intermediate preparation as effective ingredient, the variant auxiliary material of compatibility is prepared into a series of antiviral antibiotic preparation.This class medicine, to virus infectiones such as viral hepatitis, specific therapeutic action.
The fat-soluble Cantharidin intermediate preparation of the present invention reaches the method that is prepared agent by this intermediate preparation, shown in Production Flow Chart Fig. 1.Among Fig. 1: 1, pulverizer; 2, lixiviate jar I; 3, lixiviate jar II; 4, separator I; 5, separator II; 6, separator III; 7, treatment tank I; 8, treatment tank II; 9, preparation still; 10, pharmacy still.
Wherein, pulverizer 1 is made up of pulverizer and two ones in moisture eliminator, the dry and pulverizing with the raw material cantharis in pulverizer 1; Lixiviate jar I 2, II 3 are made by stainless steel, pottery or glass material, utilize organic solvent or acid to add organic solvent in this jar Chinese blister beetle is flooded; The material that separator I 4, II 5, III 6 are made is identical with the lixiviate jar, solution two-phase or solid-liquid two can be separated by separator; 7 pairs of products of treatment tank I are made with extra care; In the treatment tank II 8 raw oil material is made with extra care; In the preparation still 9, Cantharidin is made fat-soluble Cantharidin intermediate preparation, and be processed into the various preparations that contain fat-soluble Cantharidin in pharmacy still 10, preparation still 9 and pharmacy still 10 are to control its temperature, the pharmaceutical equipment of stainless steel, pottery or glass.
The following step is mainly adopted in the preparation of fat-soluble Cantharidin preparation:
1, at first use organic solvent, for example dipping powders of cantharide such as acetone, chloroform, methylene dichloride, trichloromethane arrive organic phase with the composition extracting of Oleum Mylabris in the Chinese blister beetle and Cantharidin;
2, after the powder of cantharide drying through the organic solvent extracting, flood with concentrated hydrochloric acid and acetone soln, concentrated hydrochloric acid can change into Cantharidin with cantharidate again, and acetone can dissolve Cantharidin into organic phase;
3, Cantharidin and Oleum Mylabris in above-mentioned 1 the organic phase are isolated from this organic phase after, add sherwood oil, the Oleum Mylabris extracting is gone out, and Cantharidin is separated with Oleum Mylabris, Cantharidin that obtains and above-mentioned 2 isolating Cantharidins merging;
4, add a certain amount of Oleum Mylabris and by being metered into Cantharidin in refining grease, under 80～210 ℃ of temperature, normal pressure stirs heating down, makes fat-soluble Cantharidin intermediate preparation.
Specifically, fat-soluble Cantharidin intermediate preparation is pressed the step preparation:
(1) in pulverizer 1, Chinese blister beetle is being lower than and pulverizing under 55 ℃ of conditions and dry, obtaining the exsiccant powder of cantharide;
(2) powder of cantharide enters lixiviate jar (I) 2 and uses organic solvent, and for example acetone floods, soaks more than 24 hours and the repeated multiple times diafiltration, isolates organic phase and enters separator (I) 4, and solid phase enters lixiviate jar (II) 3;
(3) solid phase Chinese blister beetle granulated slag enters lixiviate jar (II) 3, and with concentrated hydrochloric acid and acetone soln dipping Chinese blister beetle granulated slag, dipping time should be more than 24 hours, and with the diafiltration of acetone repeated multiple times, isolate organic phase and enter separator (II) 5, the residue discharge;
(4) in the separator (I) 4, Cantharidin and Oleum Mylabris in the organic phase of above-mentioned (2) are separated from organic solvent-acetone, acetone reclaims, and Cantharidin and Oleum Mylabris enter separator (III) 6;
(5) in the separator (III) 6, add sherwood oil, Oleum Mylabris can be dissolved, in the separator (III) 6, Cantharidin is separated with Oleum Mylabris, Oleum Mylabris is discharged, Oleum Mylabris dissolves refining repeatedly with sherwood oil, make refining Oleum Mylabris, and Cantharidin enters in the treatment tank (I) 7;
(6) in the separator (II) 5 organic phase (there is not the concentrated hydrochloric acid of reaction and the salt that the reaction back generates) mutually and separates with inorganic, after the inorganic discharge mutually, organic solvent-acetone is separated with Cantharidin again, Cantharidin enters in the treatment tank (I) 7;
(7) in treatment tank (I) 7, Cantharidin is cleaned with sherwood oil repeatedly, use acetone, ethanol equal solvent heating for dissolving repeatedly then, crystallisation by cooling can obtain the Cantharidin crystallization.At last again to xln with the proper amount of acetone dissolving of heating repeatedly, more than the crystallisation by cooling secondary, can obtain pure crystal (containing Cantharidin more than 99%).This crystal enters preparation still 9;
(8) in treatment tank (II) 8, with grease, for example soya-bean oil, Semen Maydis oil, rapeseed oil, sunflower seed oil, sesame oil, theobroma oil, lanolin, Isopropyl myristate, Vaseline white oil etc. are made with extra care and are sterilized, and the grease after refining enters preparation still 9;
(9) in preparation still 9, with Cantharidin, after grease adds by a certain percentage, the Oleum Mylabris and the oxidation inhibitor that add metering again, (for example: Yelkin TTS, gallate ester, HBT, HBA, VE etc.), adding a small amount of Oleum Mylabris can increase and consolidate the solubleness of Cantharidin in grease.In preparation still 9, under 80～210 ℃ of temperature, heating then can make Cantharidin be dissolved in the grease under normal pressure stirred, when temperature reaches 105 ℃ of left and right sides, Cantharidin can be dissolved rapidly in grease, improves its dissolution rate of temperature again, can not significantly accelerate with the increase of temperature.In process of production, best heating for dissolving temperature is 102～110 ℃, can finish dissolution process in 30 minutes.
The preparation process of process above-mentioned (1)～(9) can make and contain Cantharidin 0.04～0.12%, Oleum Mylabris 0.1～4%, the fat-soluble Cantharidin intermediate preparation of oxidation inhibitor 0.02～2%.
The intermediate preparation of said process preparation adds other auxiliary material by a certain percentage and can prepare the various preparations that contain fat-soluble Cantharidin.Preparation process is carried out in pharmacy still 10, and preparation condition and process are described further by embodiment.
The preparation of embodiment 1 Cantharidin external application emulsifiable paste
Fat-soluble Cantharidin external application emulsifiable paste is pressed following composition:
Cantharidin: 0.12～0.3g
Grease: 250～300g
Oleum Mylabris: 1～12g
Oxidation inhibitor: 0.06～6g
Other ointment base (stearic acid, hard ester alcohol, hexadecanol, beeswax, hydrogenated vegetable oil glyceryl monostearate etc.): 80～180g
Emulsifying agent (tween, sapn, newborn lark, peregal 0 or fabaceous lecithin): 30～100g
Fungistat: an amount of
All the other distilled water total amount 1000g.
In pharmacy still 10, with emulsifying agent, distilled water is made the emulsifying agent dispersion liquid, and other ointment base is fused in the Cantharidin intermediate preparation of above-mentioned preparation, fully stirs merit down at 60～80 ℃ and grinds milk, is chilled to room temperature and gets the external application emulsifiable paste.
The preparation of embodiment 2 Cantharidin oral latex emulsions
The Cantharidin oral latex emulsion is pressed following composition:
Cantharidin: 0.04～0.10g
Oleum Mylabris: 0.1～4g
Oxidation inhibitor: 0.1～2g
Grease: 80～100g
Emulsifying agent: 5～25g
Sanitas: an amount of
Seasonings: an amount of
All the other distilled water: total amount 1000ml
In pharmacy still 10 with emulsifying agent, seasonings and a certain amount of distilled water stir or grind, become the emulsifying agent dispersion liquid, drop into the above-mentioned fat-soluble Cantharidin intermediate preparation of making, under 60～80 ℃, continue to stir or grind to form colostrum, add sanitas then and make even emulsion liquid three times in the homogenize of dispersing emulsification machine mesohigh.
The preparation of embodiment 3 fat-soluble Cantharidin sheets
Fat-soluble Cantharidin sheet is pressed following composition:
Cantharidin: 0.04～0.1g
Grease 80～100g
Oleum Mylabris 0.1～4g
Oxidation inhibitor 0.2～2g
Other is a right amount of auxiliary materials
Total amount: 2000
In pharmacy still 10, add a certain amount of auxiliary material and stir and make the auxiliary material tablet earlier, then with fat-soluble Cantharidin intermediate preparation under 40～60 ℃ of temperature, evenly infiltrate in the tablet, dressing, promptly.
Embodiment 4 Cantharidin injectable emulsion (vein)
The Cantharidin injectable emulsion is pressed following composition:
Cantharidin: 0.03～0.05g
Oleum Mylabris: 0.1～2g
Vegetables oil (Semen Maydis oil, sesame oil or soya-bean oil): 100-150g
Emulsifying agent (lecithin, general good Buddhist nun's gram or fabaceous lecithin): 7～15g
Glycerine: 0～20g
All the other are water for injection total amount 1000ml
In pharmacy still 10 with a certain amount of water for injection, emulsifying agent, glycerine are made the fabaceous lecithin dispersion liquid under nitrogen gas stream, the fat-soluble Cantharidin intermediate preparation input of above-mentioned preparation is made highly evenly emulsion, get injectable emulsion through sterilising treatment again, the injectable emulsion preparation process is operated in nitrogen atmosphere.
Except that embodiment 1～4, also can be made into fat-soluble Cantharidin capsule, soft capsule, the cantharidia liposoluble pharmaceutics of general drug effects such as capsule and pill or fat-soluble Cantharidin electuary Cantharidin coating agent.
In addition, have the fat-soluble Cantharidin of antiviral antibiosis, also can make the medicine of local drug effect, people's external virus infection wound, burn and other inflammation all had outstanding anti-inflammatory analgetic drug effect.For example can be made into:
1, Cantharidin medicine oil
It consists of:
Cantharidin: 0.0005～0.03g
Oleum Mylabris: 1～20g
Grease: 900～990g
Oxidation inhibitor: 1～20g total amount 1000g
Sterilized vegetables oil and above-mentioned fat-soluble Cantharidin intermediate preparation are reached evenly in 102～110 ℃ of stirrings in the pharmacy still, promptly get medicine oil.
2, fat-soluble Cantharidin aerosol
It consists of:
Cantharidin: 0.0005～0.02g
Grease: 800～1000g
Oleum Mylabris: 1～20g
Oxidation inhibitor: 1～20g
Propellent is an amount of
Make 3000ml
Be about to sterilize the fat-soluble Cantharidin intermediate preparation of grease and above-mentioned preparation in the pharmacy still at 102～110 ℃ of abundant stirring and evenly mixings, add an amount of propellent and make aerosol.
3, fat-soluble Cantharidin vaginal suppository
It consists of:
Cantharidin 0.0005～0.03g
Oxidation inhibitor 0.5～2g
Grease 700～900g
Other matrix (lanolin, beeswax etc.) is an amount of
Make 1000g
Be about to a certain amount of sterilization grease, lanolin anhydrous bp93, beeswax etc., the fat-soluble Cantharidin intermediate preparation of auxiliary material and above-mentioned preparation after 102～110 ℃ of stirrings are full and uniform, are cooled to 40～50 ℃ of moulding and get suppository in pharmacy still 10.
4, Cantharidin eye ointment
It consists of:
Cantharidin: 0.0005～0.03g
Grease: 700～900g
Oleum Mylabris: 1～20g
Oxidation inhibitor: 0.2～20g
Other matrix (for example beeswax, Liquid Paraffin, lanolin anhydrous bp93 etc.): an amount of
Make 1000g
The fat-soluble Cantharidin intermediate preparation of above-mentioned preparation is added sterilization grease and other matrix constantly stir down at 102～110 ℃ and make full and uniformly, cooling promptly.
5 Cantharidin ointment
Cantharidin ointment is pressed following composition:
Cantharidin: 0.0005～0.05g
Oxidation inhibitor: 0.2～20g
Grease: 700～900g
Oleum Mylabris: 1～20g
Other ointment base (stearic acid, beeswax, stearyl alcohol etc.) is an amount of
Make 1000g
Add sterilization grease, other ointment base in pharmacy still 10, in the fat-soluble Cantharidin intermediate preparation input pharmacy still 10 with above-mentioned preparation, maintain the temperature at 102～110 ℃, stir, make fully evenly, the elimination residue obtains ointment.
6, fat-soluble Cantharidin rubber plaster
It consists of:
Cantharidin: 0.005～0.1g
Grease: 80～100g
Oleum Mylabris: 0.1～4g
Oxidation inhibitor: 0.04～4g
Other matrix (as lanolin anhydrous bp93, Liquid Paraffin) 120～180g
Untreated rubber: 350～460g
Collophony: 400～500g
Zinc oxide fine powder: 500～570g
Other auxiliary material: an amount of
Gasoline: an amount of
Make: 1500g
Cream thickness is: 1.2～1.5g/100cm
2
At first rubber is dissolved in the gasoline, makes rubber cement, add fat-soluble Cantharidin intermediate preparation and other raw material of above-mentioned preparation then, mixing is applied on the calico with the coating machine, makes the rubber plaster behind the gasoline volatilization.
Utilization also can be made into fat-soluble Cantharidin supp anal similar in appearance to above-mentioned method, Cantharidin eye oil, the cantharidia liposoluble pharmaceutics of local drug effects such as fat-soluble Cantharidin liniment.
The curative effect of embodiment 5 fat-soluble Cantharidin treatment viral hepatitis
Utilize the fat-soluble Cantharidin preparation of the embodiment of the invention 1～4 preparation that Patients with Viral Hepatitis is treated, contrast Radix Isatidis injection intramuscular injection.Treatment case 50 examples, contrast case 25 examples, medication is as follows:
Treatment group (the fat-soluble Cantharidin preparation of embodiment 1～4 preparation, oral or external application)
Dosage: Cantharidin 0.01～0.025mg/kg/ day.
Control group (Radix Isatidis injection intramuscular injection)
Dosage: a twice-daily, one time 1～2
The statistics of its treatment such as table 1, table 2, table 3, term is as giving a definition in the table:
1, symptom significantly takes a turn for the better: refer to apocleisis, weak, detest in three kinds of symptoms of oil two or more remarkable improvement;
2, transference cure: appetite reaches normally, does not mind oil, and antisecosis is normal;
3, acute hepatitis is failed to respond to any medical treatment: medication loseed subjective symptoms in 5 days and is clearly better to invalid.
4, chronic hepatitis treatment is invalid: medication loseed subjective symptoms in 10 days and is clearly better to invalid.
Cantharidin is mainly chemically examined the diagnostic data table before treating acute and chronic medicine for curing hepatitis
Table 1
By the morning of table as a result of above embodiment, the preparation that utilizes the present invention to prepare is a kind of effective medicine of treatment viral hepatitis.
Cantharidin is treated the efficient cartogram of acute and chronic hepatitis
Table 2
Cantharidin is treated the effective patient's curative effect of acute and chronic hepatitis progress cartogram
Table 3
Claims (9)
1, a kind of preparation method of fat-soluble Cantharidin intermediate preparation comprises that characteristics of the present invention are that preparation process is as follows with acid treatment insect powder of cantharide and utilize organic solvent to extract Cantharidin from powder of cantharide:
(1) use organic solvent, for example acetone, sherwood oil, chloroform cold soaking powder of cantharide reclaim organic solvent, must contain the mixed extract of Oleum Mylabris, Cantharidin etc.;
(2) will flood with concentrated hydrochloric acid and acetone soln again after doing through above-mentioned 1 powder of cantharide of handling, separate organic phase and can obtain Cantharidin;
(3) Cantharidin and Oleum Mylabris in above-mentioned 1 the organic phase are isolated from this organic phase after, add sherwood oil, the Oleum Mylabris extracting is gone out and Cantharidin is separated with Oleum Mylabris, gained Cantharidin and above-mentioned (2) obtain Cantharidin and merge, repeatedly with after the petroleum ether, use acetone, ethanol equal solvent heating for dissolving repeatedly again, crystallisation by cooling makes Cantharidin;
(4) add a certain amount of Oleum Mylabris oxidation inhibitor and according to dosage drop into Cantharidin in refining grease, under 80～210 ℃ of temperature, normal pressure stirs heating down, makes fat-soluble Chinese blister beetle disposition intermediate preparation.
2, according to the Heating temperature in the described method of claim 1, its best Heating temperature is 102～110 ℃.
3, a kind of outer preparation method who is coated with anti-virus formulation Cantharidin external application emulsifiable paste who contains according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1 is characterized in that this emulsifiable paste contains following composition:
Cantharidin: 0.12～0.3g
Grease: 250～300g
Oleum Mylabris: 0.3～12g
Oxidation inhibitor: 0.06～6g
Other ointment base: 80～180g
Emulsifying agent: 30～100g
Fungistat: an amount of
All the other distilled water total amount 1000g.
Its emulsifiable paste adopts following method preparation:
In the pharmacy still emulsifying agent and a certain amount of distilled water are made the emulsifying agent dispersion liquid, fat-soluble Cantharidin intermediate preparation and other ointment base of adding according to the described method preparation of claim 1 fully stir or grind evenly down in 60～80 ℃, make emulsifiable paste.
4, a kind of antiviral anti-inflammatory preparation of local external use's drug effect of the fat-soluble Cantharidin intermediate preparation for preparing according to the described method of claim 1, preparation method of Cantharidin ointment of containing is characterized in that this ointment contains following composition:
Cantharidin: 0.0005～0.05g
Oleum Mylabris: 1～20g
Oxidation inhibitor: 0.2～20g
Grease: 700～900g
Other ointment base: an amount of
Make: 1000g
Its ointment adopts following method preparation:
Grease, other ointment base of adding sterilization in the pharmacy still add the fat-soluble Cantharidin intermediate preparation according to the described method preparation of claim 1 again, maintain the temperature at 102～110 ℃, stir, and make ointment.
5, a kind of anti-virus formulation for oral use that contains according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1, the preparation method of the oral breast of Cantharidin is characterized in that this oral breast contains following composition:
Cantharidin: 0.04～0.10g
Oleum Mylabris: 0.1～4g
Oxidation inhibitor: 0.1～2g
Grease: 80～100g
Emulsifying agent: 5～25g
Sanitas: an amount of
Seasonings: an amount of
All the other distilled water: total amount 1000ml
Its emulsion adopts following method preparation:
In the pharmacy still, add emulsifying agent, seasonings and a certain amount of distilled water stir or grind, become the emulsifying agent dispersion liquid, input is according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1,60～80 ℃ of temperature, stir or grind evenly one-tenth colostrum, dispersing emulsification machine mesohigh homogenize three times, make emulsion then.
6, a kind of anti-virus formulation for oral use that contains according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1, the preparation method of fat-soluble Cantharidin sheet is characterized in that said preparation contains following composition:
Cantharidin: 0.04～0.1g
Grease: 80～100g
Oleum Mylabris: 0.1～4g
Oxidation inhibitor: 0.2～2g
Other is a right amount of auxiliary materials
Make 2000
Its tablet adopts following method preparation:
In the pharmacy still, add a certain amount of auxiliary material and stir and make the auxiliary material tablet earlier, will according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1 under 40～60 ℃ of temperature, evenly infiltrate in the tablet then, dressing, promptly.
7, a kind of injection anti-virus formulation that contains according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1, the preparation method of Cantharidin injectable emulsion is characterized in that this medicine contains following composition:
Cantharidin: 0.03～0.05g
Vegetables oil: 100～150g
Oleum Mylabris: 0.1～2g
Emulsifying agent: 7～15g
Glycerine: 0～20g
All the other are water for injection total amount 1000ml
Its injectable emulsion adopts following method preparation:
In the pharmacy still, a certain amount of water for injection and emulsifying agent are made the emulsifying agent dispersion liquid, add fat-soluble Cantharidin intermediate preparation, in nitrogen gas stream, make injectable emulsion highly uniformly according to the described method preparation of claim 1.
8, a kind of antiviral and anti-inflammatory that contains the local drug effect of the fat-soluble Cantharidin intermediate preparation for preparing according to the described method of claim 1, the preparation method of fat-soluble Cantharidin vaginal suppository is characterized in that this medicine contains following composition:
Cantharidin: 0.0005～0.03g
Oxidation inhibitor: 0.5～2g
Grease: 700～900g
Cantharidin: 1～20g
Other matrix (lanolin, beeswax etc.): an amount of
Making total amount is 1000g
Its suppository adopts following method preparation:
In the pharmacy still, add a certain amount of sterilization grease, anhydrous wool tire, beeswax etc., the fat-soluble Cantharidin intermediate preparation that reaches according to the described method preparation of claim 1 stirs under 102～110 ℃, is cooled to 40～50 ℃ of moulding and gets suppository.
9, a kind of antiviral anti-inflammatory preparation of local external use's drug effect that contains according to the fat-soluble Cantharidin intermediate preparation of the described method preparation of claim 1, the preparation method of Cantharidin eye ointment is characterized in that this eye ointment contains following composition:
Cantharidin: 0.0005～0.03g
Grease: 700～900g
Oleum Mylabris: 1～20g
Oxidation inhibitor: 0.2～20g
Other matrix (as Liquid Paraffin beeswax, anhydrous wool tire etc.) is an amount of
Making total amount is 1000g
Its eye ointment adopts following method preparation:
In the pharmacy still, add sterilization grease, other matrix (as Liquid Paraffin, beeswax, lanolin anhydrous bp93), add fat-soluble Cantharidin intermediate preparation then, under 102～110 ℃, stir, make eye ointment according to the described method preparation of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN90106365A CN1029771C (en) | 1990-08-29 | 1990-08-29 | Cantharidin fat-soluble medicament preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN90106365A CN1029771C (en) | 1990-08-29 | 1990-08-29 | Cantharidin fat-soluble medicament preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1059338A true CN1059338A (en) | 1992-03-11 |
| CN1029771C CN1029771C (en) | 1995-09-20 |
Family
ID=4880006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN90106365A Expired - Fee Related CN1029771C (en) | 1990-08-29 | 1990-08-29 | Cantharidin fat-soluble medicament preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1029771C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1454624A1 (en) * | 2001-11-23 | 2004-09-08 | Wei Wang | Antiviral, antibacterial pharmaceutical composition of cantharidic anhydride and method of preparation thereof |
| WO2004103362A1 (en) * | 2003-05-09 | 2004-12-02 | Wei Wang | Formulation of the total anhydrides of cantharidin for the treatment and prevention of severe acute respiratory syndrome infections and the preparation thereof |
| CN102796794A (en) * | 2012-08-31 | 2012-11-28 | 哈尔滨工业大学 | Preparation method of cantharis toxin |
-
1990
- 1990-08-29 CN CN90106365A patent/CN1029771C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1454624A1 (en) * | 2001-11-23 | 2004-09-08 | Wei Wang | Antiviral, antibacterial pharmaceutical composition of cantharidic anhydride and method of preparation thereof |
| EP1454624A4 (en) * | 2001-11-23 | 2006-05-31 | Wei Wang | Antiviral, antibacterial pharmaceutical composition of cantharidic anhydride and method of preparation thereof |
| WO2004103362A1 (en) * | 2003-05-09 | 2004-12-02 | Wei Wang | Formulation of the total anhydrides of cantharidin for the treatment and prevention of severe acute respiratory syndrome infections and the preparation thereof |
| CN102796794A (en) * | 2012-08-31 | 2012-11-28 | 哈尔滨工业大学 | Preparation method of cantharis toxin |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1029771C (en) | 1995-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101066340A (en) | Compound externally applied tetrodotoxin ointment and its prepn | |
| CN1895663A (en) | Repairing paste of emu oil and its proudction | |
| CN1036046C (en) | Preparation for cantharidia liposoluble pharmaceutics | |
| CN1281230C (en) | Medicine composition for curing burn, scald and mucocutaneous ulcer | |
| CN1059338A (en) | The preparation of cantharidia liposoluble pharmaceutics | |
| CN1034574C (en) | Process for preparing (RS)-2-(2,3-dihydro-5-hydroxy--4,6,7-trimethylbenzofuranyl) acetic acids and 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofuranyl) acetic acids and esters thereof, and their..... | |
| CN1253159C (en) | Health product of compound propolis and preparing method | |
| CN1823910A (en) | Joint pain preparation and its new preparation method | |
| CN1803185A (en) | Compound zedoary turmeric oil gelata and its preparing method | |
| CN1748757A (en) | Dragon's blood external use preparation and its preparing method | |
| CN1544032A (en) | Anticancer Chinese traditional extracts and preparation process and application thereof | |
| CN1748758A (en) | Dragon's blood gel preparation and its preparing method | |
| CN1660140A (en) | Activity combination of marine life and application | |
| CN1887906A (en) | Hypoglycemic polypeptide from silkworm and its prepn and use | |
| CN1927290A (en) | Ointment for treating naevus and preparing method thereof | |
| CN1301100C (en) | Nauclea officinalis drip pill and its preparation method | |
| CN1686488A (en) | Medicine for treating malignant tumour and its production method | |
| CN1720946A (en) | Bone strengthening dripping pills with Premena fulva craib as raw material and method for preparing the same | |
| CN101036681A (en) | Analgesic aconitum flavum | |
| CN1189200C (en) | Ointment for treating burn and scald | |
| CN1583043A (en) | Duyiwei extract and its preparation and use | |
| CN1686432A (en) | Earthworm drip pill and its preparation method | |
| CN1634481A (en) | Honeysuckle flower soft capsule and preparation method thereof | |
| CN1301107C (en) | Xiyanping drop pills of possessing function of clearing away heat and toxic materia and preparation method | |
| CN1092661A (en) | A kind of medicine for the treatment of acquired immune deficiency syndrome (AIDS) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 19950920 Termination date: 20090929 |