CN1927290A - Ointment for treating naevus and preparing method thereof - Google Patents
Ointment for treating naevus and preparing method thereof Download PDFInfo
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Abstract
The present invention involves hemorrhoid removal ointment and its preparation methods; the hemorrhoid removal ointment is manufactured by the following raw materials by weight portion: bear gall powder 5-50 portions; garden burnet root 100-500 portions, borneol 5-50 portions. Its preparation methods steps are as follows: 1) recipe bear gall powder, borneol and crush them separately, get the powder mixture standby; 2) recipe garden burnet root and add water fro decoction, the obtained extraction is filtered and condensed into thick paste which is dried and crushed into powder and mixed with powder got from Step 1) and blended, adding ointment frequently used excipients, mixing, heating, stirring and the hemorrhoid removal ointment is obtained.
Description
(1) technical field:
The present invention relates to treat the ointment of hemorrhoid, particularly ointment for treating naevus; The present invention also will disclose the preparation method of this ointment for treating naevus.
(2) background technology:
Anal and bowel pile is commonly called as hemorrhoid, is the vascular venous varicose that occurs in the anus position, is modern's commonly encountered diseases, frequently-occurring disease.Show that according to interrelated data the sickness rate of anorectal disease is 59.1%, hemorrhoid account for 87.25% in all anal and intestinal diseases, and wherein common with internal hemorrhoid, account for 52.19% of all anal and intestinal diseases.Any age all may fall ill, and wherein the people in 20-40 year comparatively more sees, and can increase the weight of gradually along with the increase at age, so saying of " ten people, nine hemorrhoid " arranged.The medicament categories that is used for the treatment of hemorrhoid of Xiao Shouing is various in the market, oral medicine is arranged, suppository, unguentum etc., for example application number is: 01108561.4, name is called the Chinese invention patent of " ointment for curing hemorrhoids ", it discloses a kind of externally applied ointment for the treatment of hemorrhoid, this plaster adds the vaseline mixed preparing by following component and forms after Chinese medicine technology is fried in shallow oil stir-fry process of preparing Chinese medicine pulverizing: Rhizoma Picrorhizae 5～50g, Fel Ursi 5～20g, catechu 5～50g, Borneolum Syntheticum 5～20g, Sanguis Draxonis 5～50g, Squama Manis 5～30g, Olibanum 5～50g, Myrrha 5～50g, Radix Notoginseng 5～50g, Venenum Bufonis 1～10g, Radix Et Rhizoma Rhei 0～50g, Hydrargyrum chloratum Compositum 0.1～2g, Rhizoma Zingiberis Recens 5～50g, vaseline 100～200g, Aloe, Radix Rhapontici, a kind of in the Radix Sanguisorbae or two kinds or three kinds, addition is Aloe 5～50g, Radix Rhapontici 5～50g, Radix Sanguisorbae 5～50g, this product plays certain therapeutical effect to hemorrhoid.But the raw material type of this plaster is more, the compatibility complexity, and the interaction between each raw material influences the volatilization of drug effect easily; Selected for use the bigger raw materials of toxicity such as Venenum Bufonis, Radix Et Rhizoma Rhei to be prepared in addition, this plaster of life-time service may cause adverse effect to human body.
(3) summary of the invention:
The present invention will disclose a kind of fill a prescription simple, therapeutic effect is good, the ointment for treating naevus of efficacy stability; The present invention also will disclose the preparation method of this ointment for treating naevus.
Ointment for treating naevus of the present invention is to be made by following crude drug in weight portion:
Fel Ursi powder 5-50 part; Radix Sanguisorbae 100-500 part; Borneolum Syntheticum 5-50 part.
The consumption of each raw material all has better curative effect in above-mentioned weight portion scope, but can be according to the different concrete more suitably prescription of selecting of patient's symptom.For example following several assembly can be brought into play better detumescence, hemostasis, analgesic effect:
The proportioning of crude drug of the present invention also can be as follows in weight portion:
Fel Ursi powder 5-35 part; Radix Sanguisorbae 100-300 part; Borneolum Syntheticum 5-35 part.
The preferred proportioning of above-mentioned each crude drug is as follows in weight portion:
Fel Ursi powder 10-35 part; Radix Sanguisorbae 150-300 part; Borneolum Syntheticum 10-35 part.
Another preferred proportioning of above-mentioned each crude drug is as follows in weight portion:
Fel Ursi powder 10-30 part; Radix Sanguisorbae 150-250 part; Borneolum Syntheticum 10-30 part.
Following several prescription then has better hemostasis, protection mucosa and promotes the effect of tissue repair:
The proportioning of each crude drug of the present invention also can be as following in weight portion:
Fel Ursi powder 20-50 part; Radix Sanguisorbae 300-500 part; Borneolum Syntheticum 20-50 part.
The preferred proportioning of above-mentioned each crude drug is as follows in weight portion:
Fel Ursi powder 20-45 part; Radix Sanguisorbae 300-450 part; Borneolum Syntheticum 20-45 part.
Another preferred proportioning of above-mentioned each crude drug is as follows in weight portion:
Fel Ursi powder 20-40 part; Radix Sanguisorbae 300-400 part; Borneolum Syntheticum 20-40 part.
The another preferred proportioning of above-mentioned each crude drug is as follows in weight portion:
Fel Ursi powder 20-35 part; Radix Sanguisorbae 300-350 part; Borneolum Syntheticum 20-35 part.
Ointment for treating naevus of the present invention can be prepared according to traditional Chinese herb medicine tradition or conventional preparation method, and for example with three kinds of raw material pulverizing, mix homogeneously, refabrication becomes ointment, or earlier three kinds of raw waters is carried, and filtrate is condensed into cream, is prepared into ointment with conventional method again; For making each raw material bring into play drug effect better, preferably adopt following method preparation, this method step is as follows:
1) get Fel Ursi powder, Borneolum Syntheticum pulverize separately, it is standby to obtain mixed powder;
2) get Radix Sanguisorbae and decoct with water, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add ointment adjuvant commonly used, as white vaseline, lanoline, paraffin, Cera Flava etc., mixing, heated and stirred obtains ointment for treating naevus; Time, number of times and temperature that wherein said raw material water decocts can be determined according to actual needs, water is carried the time and was generally can be controlled in 0.5～20 hour, certainly also can prolong accordingly as required, above 20 hours, extraction time generally can be 1～5 time, and each extraction time is to be advisable in 0.5～4 hour; The weight ratio of mixed powder and water is preferably 1: 1～and 8, also can determine according to actual needs certainly; Decoct temperature and generally can be controlled in 50～100 ℃, certainly lower the or height of temperature a bit also can, low as decocting temperature, decocting time is a little with regard to corresponding prolongation.
Certainly the method for Chinese medicinal of raw material of the present invention with routine can also be prepared into other dosage form, as each raw material being ground into powder and mix homogeneously is made powder; Or each raw material is carried out water carry, then concentrated filtrate is become cream, obtain unguentum; During use, be applied directly to patient part and get final product.
Ointment for treating naevus of the present invention is only formulated by Radix Sanguisorbae, Borneolum Syntheticum, Fel Ursi powder three flavor Chinese medicines; its prescription is simple, scientific and reasonable; have heat-clearing and toxic substances removing, pain relieving, dampness removing, detumescence, removing heat from blood, hemostatic effect; and its drug release absorbent properties are good; onset time is fast; the drug effect performance rapidly; effect with pain relieving, antiinflammatory, protection mucosa and promotion tissue repair; be applicable to the treatment of inflammatory due to stagnancy of wind and heat or the stagnancy of damp-heat, thrombosed external hemorrhoid, internal hemorrhoid; be the treatment inflammatory external hemorrhoid, thrombosed external hemorrhoid and I, the comparatively ideal medicine for external use of II phase internal hemorrhoid.Before the medication, clean the part with warm water earlier, treatment internal hemorrhoid: injection head is inserted in the anus gently, plaster is pushed in the anus; The treatment external hemorrhoid: plaster is evenly applied the affected part, and external cleaning gauze covers.A drug amount 2-3g, 2 times on the one.Ointment for treating naevus preparation technology of the present invention is simple, quality controllability is strong, be beneficial to suitability for industrialized production, reduces cost and the medicine valency, reduces the patient burden and it is esy to use, safe and reliable, have no side effect.
(4) specific embodiment:
Embodiment 1:
1) get Fel Ursi powder 5 grams, Borneolum Syntheticum 5 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 100 gram Radix Sanguisorbaes puts into 2 times of decoctings to its weight and boils 3 times, the each decoction 0.5 hour decocts temperature and is controlled at 80 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 750 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 2:
1) get Fel Ursi powder 50 grams, Borneolum Syntheticum 50 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 100 gram Radix Sanguisorbaes puts into 4 times of decoctings to its weight and boils 2 times, the each decoction 4 hours decocts temperature and is controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 600 gram white vaseline, 250 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 3:
1) get Fel Ursi powder 5 grams, Borneolum Syntheticum 50 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 500 gram Radix Sanguisorbaes puts into 6 times of decoctings to its weight and boils 3 times, the each decoction 3 hours decocts temperature and is controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 650 gram white vaseline, 250 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 4:
1) get Fel Ursi powder 35 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) get 300 gram Radix Sanguisorbaes and put into 3 times of decoctings to its weight and boil 4 times, first and second time is each to decoct 2 hours, and third and fourth time is each to decoct 1 hour, decoct temperature and be controlled at 95 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 650 gram paraffin, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 5:
1) get Fel Ursi powder 10 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 150 gram Radix Sanguisorbaes puts into the decocting identical with its weight and boils, decocted 5 hours, and decocted temperature and be controlled at 100 ℃, the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 680 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 6:
1) get Fel Ursi powder 30 grams, Borneolum Syntheticum 10 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 250 gram Radix Sanguisorbaes puts into 5 times of decoctings to its weight and boils 3 times, each time that decocts was respectively 2,1.5,1 hours, decocted temperature and was controlled at 70 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 300 gram white vaseline, 650 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 7:
1) get Fel Ursi powder 45 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 450 gram Radix Sanguisorbaes puts into 6 times of decoctings to its weight and boils 5 times, the each decoction 2 hours decocts temperature and is controlled at 85 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 200 gram white vaseline, 100 gram paraffin, 550 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 8:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 40 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 300 gram Radix Sanguisorbaes puts into 4 times of decoctings to its weight and boils 2 times, the each decoction 5 hours decocts temperature and is controlled at 95 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 300 gram white vaseline, 550 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 9:
1) get Fel Ursi powder 40 grams, Borneolum Syntheticum 50 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 400 gram Radix Sanguisorbaes puts into 6 times of decoctings to its weight and boiled 20 hours, decoct temperature and be controlled at 100 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 700 gram white vaseline, 100 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 10:
1) get Fel Ursi powder 35 grams, Borneolum Syntheticum 45 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 500 gram Radix Sanguisorbaes puts into 6 times of decoctings to its weight and boils 4 times, the each decoction was respectively 2,1.5,1,0.5 hours, decocted temperature and was controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 100 gram white vaseline, 700 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 11:
1) get Fel Ursi powder 15 grams, Borneolum Syntheticum 15 gram pulverize separately, it is standby to obtain mixed powder;
2) get 150 gram Radix Sanguisorbaes and put into 2 times of decoctings to its weight and boil 3 times, first and second time is each to decoct 2 hours, decocted for the third time 1 hour, decoct temperature and be controlled at 95 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 750 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 12:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 20 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 100 gram Radix Sanguisorbaes puts into 4 times of decoctings to its weight and boils 2 times, the each decoction 4 hours decocts temperature and is controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 710 gram white vaseline, 250 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 13:
1) get Fel Ursi powder 15 grams, Borneolum Syntheticum 45 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 300 gram Radix Sanguisorbaes puts into 3 times of decoctings to its weight and boils 3 times, the each decoction 3 hours decocts temperature and is controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 650 gram white vaseline, 250 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 14:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) get 400 gram Radix Sanguisorbaes and put into 3 times of decoctings to its weight and boil 4 times, first and second time is each to decoct 2 hours, and third and fourth time is each to decoct 1 hour, decoct temperature and be controlled at 95 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 650 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 15:
1) get Fel Ursi powder 10 grams, Borneolum Syntheticum 25 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 350 gram Radix Sanguisorbaes puts into the decocting identical with its weight and boils 3 times, the each decoction was respectively 2,1.5,1 hours, decocted temperature and was controlled at 100 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 680 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 16:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 25 gram pulverize separately, it is standby to obtain mixed powder;
2) get 250 gram Radix Sanguisorbaes and put into 2 times of decoctings and boil 3 times, be followed successively by 2,1.5,1 hours, decocted for the third time 1 hour to its weight, decoct temperature and be controlled at 100 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 700 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 17:
1) get Fel Ursi powder 25 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 450 gram Radix Sanguisorbaes puts into 6 times of decoctings to its weight and boils 5 times, the each decoction 2 hours decocts temperature and is controlled at 85 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 250 gram white vaseline, 650 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 18:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 300 gram Radix Sanguisorbaes puts into 4 times of decoctings to its weight and boils 2 times, be followed successively by 2,1.5 hours, and decocted temperature and be controlled at 95 ℃, the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 350 gram white vaseline, 550 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 19:
1) get Fel Ursi powder 45 grams, Borneolum Syntheticum 45 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 100 gram Radix Sanguisorbaes puts into 5 times of decoctings to its weight and boiled 20 hours, decoct temperature and be controlled at 100 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 720 gram white vaseline, 130 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 20:
1) get Fel Ursi powder 30 grams, Borneolum Syntheticum 45 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 150 gram Radix Sanguisorbaes puts into 3 times of decoctings to its weight and boils 4 times, the each decoction was respectively 2,1.5,1,0.5 hours, decocted temperature and was controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 150 gram white vaseline, 700 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 21:
1) get Fel Ursi powder 5 grams, Borneolum Syntheticum 45 gram pulverize separately, it is standby to obtain mixed powder;
2) get 150 gram Radix Sanguisorbaes and put into 2 times of decoctings to its weight and boil 3 times, first and second time is each to decoct 2 hours, decocted for the third time 1 hour, decoct temperature and be controlled at 95 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 700 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 22:
1) get Fel Ursi powder 10 grams, Borneolum Syntheticum 10 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 120 gram Radix Sanguisorbaes puts into 4 times of decoctings to its weight and boils 2 times, the each decoction 4 hours decocts temperature and is controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 710 gram Cera Flavas, 260 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 23:
1) get Fel Ursi powder 15 grams, Borneolum Syntheticum 35 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 260 gram Radix Sanguisorbaes puts into 3 times of decoctings to its weight and boils 3 times, the each decoction 3 hours decocts temperature and is controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 750 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 24:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 30 gram pulverize separately, it is standby to obtain mixed powder;
2) get 380 gram Radix Sanguisorbaes and put into 3 times of decoctings to its weight and boil 4 times, first and second time is each to decoct 2 hours, and third and fourth time is each to decoct 1 hour, decoct temperature and be controlled at 95 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 680 gram white vaseline, 230 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 25:
1) get Fel Ursi powder 15 grams, Borneolum Syntheticum 25 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 250 gram Radix Sanguisorbaes puts into 2 times of decoctings to its weight and boils 3 times, the each decoction was respectively 2,1.5,1 hours, decocted temperature and was controlled at 100 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 730 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 26:
1) get Fel Ursi powder 25 grams, Borneolum Syntheticum 25 gram pulverize separately, it is standby to obtain mixed powder;
2) get 180 gram Radix Sanguisorbaes and put into 4 times of decoctings and boil 3 times, be followed successively by 1.5,1,0.5 hours, decocted for the third time 1 hour to its weight, decoct temperature and be controlled at 90 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 550 gram white vaseline, 350 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 27:
1) get Fel Ursi powder 25 grams, Borneolum Syntheticum 15 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 280 gram Radix Sanguisorbaes puts into 6 times of decoctings to its weight and boils 5 times, the each decoction 2 hours decocts temperature and is controlled at 85 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 470 gram white vaseline, 450 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 28:
1) get Fel Ursi powder 20 grams, Borneolum Syntheticum 10 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 300 gram Radix Sanguisorbaes puts into 4 times of decoctings to its weight and boils 2 times, be followed successively by 2,1.5,1 hours, and decocted temperature and be controlled at 95 ℃, the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 250 gram white vaseline, 660 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 29:
1) get Fel Ursi powder 45 grams, Borneolum Syntheticum 50 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 100 gram Radix Sanguisorbaes puts into 2 times of decoctings to its weight and boiled 20 hours, decoct temperature and be controlled at 100 ℃, the gained water extraction filters, and is condensed into thick paste, drying, be ground into powder, and with the mixed powder mixing of step 1) gained, add 650 gram white vaseline, 200 gram lanolines, mixing, heated and stirred obtains ointment for treating naevus.
Embodiment 30:
1) get Fel Ursi powder 30 grams, Borneolum Syntheticum 30 gram pulverize separately, it is standby to obtain mixed powder;
2) getting 150 gram Radix Sanguisorbaes puts into 3 times of decoctings to its weight and boils 4 times, the each decoction was respectively 2,1.5,1,0.5 hours, decocted temperature and was controlled at 90 ℃, and the gained water extraction filters, be condensed into thick paste, drying is ground into powder, and with the mixed powder mixing of step 1) gained, add 120 gram paraffin, 100 gram silicone oil, 650 gram Cera Flavas, mixing, heated and stirred obtains ointment for treating naevus.
Experimental example 1:
420 examples (wherein use embodiment 24 described ointment for treating naevus 300 examples, matched group is for using the most influential domestic a kind of ointment " MAYINGLONG MUSK HEMORRHOID UNGUENTUM " 120 examples for the treatment of hemorrhoid at present) clinical and experimental study is carried out in the clinical pharmacology base.
Usage: clean the part with warm water before the medication, treatment internal hemorrhoid: injection head is inserted in the anus gently, plaster is pushed in the anus; The treatment external hemorrhoid: plaster is evenly applied the affected part, and external cleaning gauze covers.Once use 2-3g ointment, 2 times on the one.
Clinical Comparison Study result is as follows:
| Title | Case | Total effective rate | Total obvious effective rate |
| Ointment for treating naevus | 300 | 97.0％ | 78.0％ |
| Matched group | 120 | 87.5％ | 40.8％ |
Embodiment 24 described ointment for treating naevus are 78.0% to total obvious effective rate of hemorrhoid treating, and total effective rate is 97.0%, and the two is apparently higher than matched group.And this ointment for treating naevus is not seen toxic and side effects and untoward reaction after 300 routine treatment group medications, 100 examples are carried out safety inspection, and the contrast no abnormality seen changes before and after the medication, and is safe and reliable.
In addition, this product acute toxicity and long term toxicity test have been carried out.Inject the rat rectum to be equivalent to clinical 420 times dosage, animal is observed a week, and visual examination is normal, does not find that anus and rectum have pathological change; Give rat anus medication two months with the dosage that is equivalent to clinical 210 times and 105 times, visual examination is normal, does not find that obvious histopathology changes.
Claims (9)
1, ointment for treating naevus is characterized in that it is to be made by following crude drug in weight portion:
Fel Ursi powder 5-50 part; Radix Sanguisorbae 100-500 part; Borneolum Syntheticum 5-50 part.
2, ointment for treating naevus according to claim 1 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 5-35 part; Radix Sanguisorbae 100-300 part; Borneolum Syntheticum 5-35 part.
3, ointment for treating naevus according to claim 2 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 10-35 part; Radix Sanguisorbae 150-300 part; Borneolum Syntheticum 10-35 part.
4, ointment for treating naevus according to claim 3 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 10-30 part; Radix Sanguisorbae 150-250 part; Borneolum Syntheticum 10-30 part.
5, ointment for treating naevus according to claim 1 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 20-50 part; Radix Sanguisorbae 300-500 part; Borneolum Syntheticum 20-50 part.
6, ointment for treating naevus according to claim 5 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 20-45 part; Radix Sanguisorbae 300-450 part; Borneolum Syntheticum 20-45 part.
7, ointment for treating naevus according to claim 6 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 20-40 part; Radix Sanguisorbae 300-400 part; Borneolum Syntheticum 20-40 part.
8, ointment for treating naevus according to claim 7 is characterized in that the proportioning of each crude drug is as follows in weight portion:
Fel Ursi powder 20-35 part; Radix Sanguisorbae 300-350 part; Borneolum Syntheticum 20-35 part.
9, the preparation method of ointment for treating naevus, its step is as follows:
1) get Fel Ursi powder, Borneolum Syntheticum pulverize separately, it is standby to obtain mixed powder;
2) get Radix Sanguisorbae and decoct with water, the gained water extraction filters, and is condensed into thick paste, and drying is ground into powder, and with the mixed powder mixing of step 1) gained, add ointment adjuvant commonly used, mixing, heated and stirred obtains ointment for treating naevus.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494937A (en) * | 2013-09-10 | 2014-01-08 | 姚自功 | Medicament for treating hemorrhoid |
| CN105125782A (en) * | 2015-10-26 | 2015-12-09 | 李景春 | Drug for treating hemorrhoids |
| CN111195293A (en) * | 2020-02-12 | 2020-05-26 | 常德集智生物科技有限公司 | Green hemorrhoid powder |
-
2006
- 2006-09-09 CN CNB2006100218308A patent/CN100518771C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494937A (en) * | 2013-09-10 | 2014-01-08 | 姚自功 | Medicament for treating hemorrhoid |
| CN105125782A (en) * | 2015-10-26 | 2015-12-09 | 李景春 | Drug for treating hemorrhoids |
| CN111195293A (en) * | 2020-02-12 | 2020-05-26 | 常德集智生物科技有限公司 | Green hemorrhoid powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100518771C (en) | 2009-07-29 |
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