CN101036681A - Analgesic aconitum flavum - Google Patents
Analgesic aconitum flavum Download PDFInfo
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- CN101036681A CN101036681A CN 200710100738 CN200710100738A CN101036681A CN 101036681 A CN101036681 A CN 101036681A CN 200710100738 CN200710100738 CN 200710100738 CN 200710100738 A CN200710100738 A CN 200710100738A CN 101036681 A CN101036681 A CN 101036681A
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- radix aconiti
- alkaloid
- aconiti szechenyiani
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- aconitine
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Abstract
The invention relates to an acesodyne Hui drug of radix aconiti, characterized that the Hui drug as a sustained release tablet, a sustained release capsule, a sustained release gel, a partial injection and an external use ointment is prepared by aconitum szechenyianum gay alkaloids as main materials. The invention developed based on theory of four body fluids of Hui doctor has the following advantages: 1 the main material used in the invention is an active ingredient of total alkaloids after extracted and purified instead of crude extractum, which not only requires less dosage, but is capable of completely giving drug action; 2 according to the sustained release preparation of the invention, toxiciy is reduced, a predetermined blood drug level can be maintained for a long time, and giving the drug once per day can reduce dosage, be greatly convenient for patient, improve compliance of the patient and maintain therapeutic effect.
Description
Technical field
The invention belongs to biological pharmacy technical field, particularly relate to a kind of analgesic aconitum flavum.
Background technology
China Hui ethnic group medicine and pharmacology are summary of experience and wisdom crystallizations that the vast people of the Hui ethnic group struggle with disease for a long time, and abundant medical practice is not only arranged, and have unique theoretical system and diagnosis and treatment characteristic.Medicine has carried out lot of documents research and Ethnobotany investigation back is found by distinguishing the flavor of back to 123: area, Liu Pan Shan, the Ningxia Hui ethnic group is used for the treatment of the Radix aconiti szechenyiani of multiple bone aching for a long time, have another name called Herba Achilleae, careless bud, be the tuber of successive dynasties Ningxia south Hui ethnic group wild plant FUMAO Radix aconiti szechenyiani (Aconitum flavumHand.-Mazz) commonly used among the people.According to incompletely statistics, use in 38 kinds of compound Chinese patent medicines and the national patent medicine or based on this medicine.At present, because the increase of the clinical scope of application and demand, this wild plant medicine from picking up from changing large commodity medical material into, are transferred to ground such as Shanghai and Gansu from the place in a large number, and income " Ningxia Chinese crude drug standard ", the main effect of this medical material of record is an expelling wind and removing dampness in this standard, and promoting blood circulation and stopping pain is mainly used in rheumatic arthralgia, traumatic injury, the carbuncle pyogenic infections from tumour or sore, toothache, treatment of diseases such as stomachache.
Summary of the invention
What the object of the present invention is to provide that a kind of foundation returns medical knowledge opinion development is the analgesic aconitum flavum that principal agent is made with the Radix aconiti szechenyiani.
Technical scheme of the present invention is:
A kind of analgesic aconitum flavum is characterized in that this time medicine is is slow releasing tablet, slow releasing capsule, gel, local injection liquid and external that principal agent the is made cream of filming by the Radix aconiti szechenyiani alkaloid.
The prescription of described slow releasing tablet is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: ethyl cellulose 0.01～0.5g;
Methylcellulose 0.01～0.6g;
Herba Urticae Cannabinae extract 0.02～5.0mg;
Borneolum Syntheticum 0.01～0.5g;
Syrup 0.01～0.5ml.
The prescription of described slow releasing capsule is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: Polyethylene Glycol 0.01～10.0g;
Cellulose acetate 0.01～10.0g;
Phosphatidylcholine 0.01～10.0g;
Gelatin 0.01～10.0g;
Herba Urticae Cannabinae extract 0.01～10.0mg;
Borneolum Syntheticum 0.01～0.8g.
The prescription of described slow releasing tablet is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: calcium alginate gel 0.01～0.5g;
Poly-butterfat 0.01～10.0g;
Starch 0.005～10.0g;
Cellulose acetate 0.01～10.0g;
Inferior cus-cus extract 0.01～58.0mg;
Herba Urticae Cannabinae extract 0.01～10.0mg;
Borneolum Syntheticum 0.01～10.0g;
Arabic gum 0.001～0.5g.
The film prescription of cream of described external is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: Polyethylene Glycol 0.01～2.8g;
Polyvinyl alcohol 0.01～10.0g;
Carbomer 0.01～10.0g;
Borneolum Syntheticum 0.01～10.0g;
Camphora 0.01～10.0g;
Azone 0.001～10.0ml;
Oleum Anisi Stellati 0.01～10.0ml;
Oleum Caryophylli 0.01～10.0ml.
The prescription of described gel is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: calcium alginate gel 0.01～10.0g;
Poly-butterfat 0.01～10.0ml;
Starch 0.005～10.0g;
Agar 0.01～10.0g;
Borneolum Syntheticum 0.01～10.0g;
Camphora 0.01～10.0g;
Azone 0.001～10.0ml;
Herba Urticae Cannabinae extract 0.01～10.0mg;
Oleum Anisi Stellati 0.01～10.0ml;
Oleum Caryophylli 0.01～10.0ml;
Oleum Curcumae 0.01～10.0ml;
Inferior cus-cus extract 0.01～10.0mg.
The developmental research of this product is carried out according to time doctor's limbs liquid theory: it is unusual that time doctor's limbs theory thinks that various pain are the interior black liquor matter of human body, cause the obstructed pain that causes of blood vessels, think that the whole body and arthralgia and nerve (meridians) are unusual so return medical theory, blood vessels are obstructed, closely related, belong to due to the blockage of main and collateral channels, " Radix aconiti szechenyiani " that " Chinese Hui ethnic group medicine " secretary is carried has expelling wind and removing dampness, promoting blood circulation and stopping pain, the effect of dredge the meridian passage, it can eliminate unusual black liquor matter in the human body, reaches the treatment disease, removes the purpose of pain; The clinical experience that the masses of the Hui ethnic group combat the disease has for a long time proved that also " Radix aconiti szechenyiani " can eliminate unusual black liquor matter in the human body, and treatment pain disease effect is obvious; The pain pathogenesis of " Radix aconiti szechenyiani " attending effectiveness and theory of Chinese medical science " cold syndrome, damp syndrome " matches.Therefore, the present invention is that principal agent is used for the treatment of general aching with the Radix aconiti szechenyiani.
The present invention selects solid slow-release, films, the preparation of liquid is as the dosage form of this medicine, mainly reach back the characteristics aspect consideration of medicine Radix aconiti szechenyiani pain relieving slow releasing preparation agent: 1. from secular doctor of the Hui ethnic group and clinical using method among the people from the characteristic of clinical practice, medicine itself, this medicine mainly be take that decocting boils, extracting juice, the method for taking, be used for the pain relieving of various pain diseases, effect is remarkable; 2. bibliographical information returns total alkaloids in the medicine " Radix aconiti szechenyiani " and has stronger antiinflammatory, analgesia drawn game anaesthetic effect, and the novel structure of from total alkali, getting the first diterpene alkaloid falls and the diterpene alkaloid class has significant antiinflammatory and analgesic activities, this Alkaloid has strong toxicity, adopts the form of sustained-release administration more favourable to the safety of guaranteeing its medication; 3. used slow releasing preparation means with the miscible and a kind of slow releasing preparation made of high molecular polymer such as natural product such as sodium alginate, castor wax and Brazil wax and carbopol and medicine is arranged; 4. the used principal agent of the present invention is the total alkaloids effective site through extraction, purification, rather than crude extract, and not only consumption is little for it, and can give full play to drug effect; 5. the patient repeatedly takes every day, will consciously or unconsciously change the scheme of taking medicine.Finding to compete 40%～70% patient according to the investigation of US and European does not follow the doctor's advice and takes medicine, miss every day 1～2 time, this situation will cause blood plasma and organize the Chinese medicine level concentration to descend, take medicine even continue, do not reach treatment concentration in a short time yet, can only could rebuild treatment level by repeated drug taking, promptly waste medicine and incured loss through delay treatment again, and the present invention makes the slow releasing preparation administration, can keep certain blood drug level in a long time, can be once a day, thus reduced administration number of times, made things convenient for patient widely, improved patient's compliance and guaranteed therapeutic effect.
Be clinical trial statistics of the present invention below:
1. criterion:
Recovery from illness: transference cure.Physical recovery is normal, limb activity freely, lower limb is raised and can be reached about 90 ° of degree, the work of can bearing a heavy burden does not all have an influence;
Effectively: cure basically. pain is clearly better, and still leaves over a part of symptom.Generally can not influence limb activity.Sign also has remarkable improvement, and straight lower limb is raised and can be reached about 80 °, participates in heavy burden work and has any problem slightly.
Take a turn for the better: pain relief, straight lower limb is raised below 70 °, and sign takes a turn for the better, and life activity does not have influence or inconvenience is arranged slightly, can not participate in heavier physical work;
Invalid: the sings and symptoms no change.
Treat 30 examples, cure, transfer to effectively, well total effective rate 28 examples (93%), invalid 3 examples (7%); The results are shown in Table 1.
Therapeutic effect statistical table after table 1 medication
| Name | Age | Diagnosis | Cure | Effectively | Take a turn for the better | Invalid | The address |
| Chen Xuexin | 49 | Rheumatism | √ | Inner Mongol You Qi | |||
| Zheng's sustainability | 38 | Rheumatism | √ | Yinchuan five hospitals | |||
| Kang Bide | 47 | Rheumatism | √ | Shi Zui mountain, Ningxia Huinong | |||
| Dong Jinfang | 42 | Rheumatoid | √ | The Ningxia Shizuishan | |||
| Ma Qixue | 47 | Rheumatism | √ | The Guyuan of Ningxia Pengyang County |
| Liao's bavin allows | 66 | Rheumatism | √ | Ningxia Wang Wa | |||
| Xie Baojin | 61 | Rheumatism | √ | The Xiji County, Ningxia | |||
| Ma Jingbo | 48 | Rheumatoid | √ | Snack street, south gate, Yinchuan, Ningxia | |||
| Zhang Lanlan | 58 | Rheumatoid | √ | Yinchuan, Ningxia Administration of State Bureau | |||
| Li Xueliang | 45 | Rheumatism | √ | The Helan County, Ningxia | |||
| Zhao Cunguan | 50 | Rheumatoid | √ | 40 li shops, Helan, Ningxia | |||
| Hu Zhongyue | 47 | Rheumatism | √ | Ningxia Da Wukou | |||
| Wang Xueming | 55 | Rheumatism | √ | Gao Jia village, Pingluo, Ningxia | |||
| Ma Wenxue | 39 | Rheumatism | √ | Qingtongxia, Ningxia Shao Gangzhen | |||
| Ma Xia | 44 | Rheumatoid | √ | Wuzhong, Ningxia Litong District | |||
| Comrade Xie | 56 | Rheumatism | √ | The Ningxia Tongxin County | |||
| Ma Yanfang | 47 | Rheumatism | √ | The Pingliang, Gansu | |||
| Li E | 67 | Rheumatism | √ | Yinchuan, Ningxia is newly by the lane | |||
| Kaohsiung | 51 | Rheumatism | √ | Guyuan of Ningxia Bei Yuan | |||
| Ha Taimu | 49 | Rheumatoid | √ | Yinchuan, Ningxia | |||
| Yang Ge | 56 | Rheumatism | √ | The river rising in Ningxia and flowing into central Shaanxi, Ningxia is former | |||
| Ma Hongxia | 52 | ?√ | Ningxia is concentric | ||||
| Cheng Xuemin | 36 | Rheumatism | √ | Ningxia is washed in a pan happy | |||
| Dong school graduates | 50 | Rheumatism | √ | Inner Mongol Zuo Qi | |||
| Luo Guorui | 60 | Rheumatism | √ | Inner Mongol Zuo Qi | |||
| Sun Wei | 45 | Rheumatism | √ | The Lingwu City, Ningxia | |||
| Jiang Xuguang | 49 | Rheumatism | √ | Guyuan of Ningxia Li Zhai | |||
| Lee's name is recruited | 67 | Rheumatoid | √ | The Xiji County, Ningxia | |||
| Wang Xueqing | 46 | Rheumatoid | √ | The Helan County, Ningxia | |||
| Wang Tingxue | 56 | Rheumatism | √ | The Yongning county, Ningxia | |||
Illustrate: this table is added up for the curative effect after the medication.Patient address is pressed the medical history record statistics.Diagnosis: blood and health check-up are made a definite diagnosis.
The specific embodiment
Embodiment 1
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 8.0mg,
Adjuvant: ethyl cellulose (EC) 0.5mg, methylcellulose (MC) 0.6mg, Herba Urticae Cannabinae extract 6.5mg, Borneolum Syntheticum 0.1mg, syrup 0.01ml.
Method for making: get Radix aconiti szechenyiani alkaloid, EC, MC, starch, Herba Urticae Cannabinae extract, Borneolum Syntheticum, syrup mixing.Granulate: adopt wet granulation, with 18E1 sieve series grain, pressure: pressure is controlled at critical pressure and is advisable during film-making, promptly improves the buoyancy of holding of tablet under the prerequisite of retention tab shape, so that floating tablets has suitable release as far as possible.Cured: the filling spice of gastric floating capsule agent must cured.The fatty adjuvant infiltrates in each component in the solidification process, after the cooling each component is closely linked, and makes preparation possess certain intensity, and is broken and have and hold buoyancy accordingly with opposing gastric peristalsis and unlikely generation.Take the method for 80 ℃ of heating 10min to be cured processing, get final product slow releasing tablet.
Embodiment 2
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 50mg,
Adjuvant: ethyl cellulose (EC) 10.0mg, methylcellulose (MC) 10.0mg, Herba Urticae Cannabinae extract 0.02g, Borneolum Syntheticum 5mg, syrup 0.5ml.
Method for making is with embodiment 1.
Embodiment 3
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 60.0mg,
Adjuvant: ethyl cellulose (EC) 250.0mg, methylcellulose (MC) 30.0mg, Herba Urticae Cannabinae extract 20.0mg, Borneolum Syntheticum 25mg, syrup 0.3ml.
Method for making is with embodiment 1.
Embodiment 4
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 0.10mg,
Adjuvant: Polyethylene Glycol 1.0mg, cellulose acetate 1.0mg, phosphatidylcholine 0.1mg, gelatin 1.0mg, Herba Urticae Cannabinae extract 5.0mg, Borneolum Syntheticum 1.0mg.
Method for making: get Radix aconiti szechenyiani alkaloid, Polyethylene Glycol, cellulose acetate, phosphatidylcholine, gelatin, Herba Urticae Cannabinae extract, Borneolum Syntheticum.Cured: the filling spice cured of gastric floating capsule agent, to reach the purpose of control drug release.The fatty adjuvant infiltrates in each component in the solidification process, after the cooling each component is closely linked.Adopt the method for the common gelatine capsule shell of 37% formaldehyde crosslinking to prepare the gastric retention type controlled release capsule, not only reach and make the buoyant purpose of preparation.And can control the release of medicine effectively, reach the controlled release purpose.Promptly get capsule.
Embodiment 5
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 50.0mg,
Adjuvant: Polyethylene Glycol 0.5mg, cellulose acetate 0.5mg, phosphatidylcholine 0.5mg, gelatin 0.8mg, Herba Urticae Cannabinae extract 7.0mg, Borneolum Syntheticum 0.4mg.
Method for making is with embodiment 4.
Embodiment 6
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 60.0mg,
Adjuvant: Polyethylene Glycol 10.0mg, cellulose acetate 10.0mg, phosphatidylcholine 10.0mg, gelatin 10.0mg, An Zhuci plain 60.0mg, Borneolum Syntheticum 8.0mg.
Method for making is with embodiment 4.
Embodiment 7
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 6.0mg,
Adjuvant: calcium alginate gel 1.0mg. gathers butterfat (PLA) 1.0mg, starch 0.5mg, Herba Urticae Cannabinae extract 5.0mg, Borneolum Syntheticum 1.0mg, arabic gum 1.0mg.
Method for making: with Radix aconiti szechenyiani alkaloid and calcium alginate gel .PLA, starch, arabic gum, Herba Urticae Cannabinae extract, the abundant mixing of Borneolum Syntheticum powder, the system soft material is crossed 20 mesh sieves and is granulated, 50 ℃ of dry 8h, and granulate adds lubricant and mixing, tabletting, promptly.
Embodiment 8
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 50.0mg,
Adjuvant: calcium alginate gel 0.2mg. gathers butterfat (PLA) 0.8mg, starch 0.8mg, Herba Urticae Cannabinae extract 0.05g, Borneolum Syntheticum 0.06g, arabic gum 0.02g.
Method for making is with embodiment 7.
Embodiment 9
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 50.0mg,
Adjuvant: calcium alginate gel 0.5mg. gathers butterfat (PLA) 10.0mg, starch 10.0mg, Herba Urticae Cannabinae extract 10.0mg, Borneolum Syntheticum 10.0mg, arabic gum 0.5mg.
Method for making is with embodiment 7.
Embodiment 10
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 6.0mg,
Adjuvant: Polyethylene Glycol (PEG) 0.01g, polyvinyl alcohol (PVA) 0.01g, carbomer 0.01g, Oleum Anisi Stellati 0.2ml, Oleum Caryophylli 0.2ml.
Method for making: by prescription carbomer dry powder is scattered in the distilled water of 15mL, placement is spent the night, and makes its abundant swelling, avoids caking; Radix aconiti szechenyiani alkaloid, Oleum Anisi Stellati, Oleum Caryophylli are added in the carbomer solution slowly, with adding with stirring, add proper ammonia and transfer to pH, the limit edged stirs and forms ointment.PVA is spent the night with soak with ethanol, and filtration press dry, and soaks 1 time again, press dry again, last dry for standby.PVA is extremely expanded with a small amount of distilled water immersion, and placement is spent the night.The PVA that soaks put be heated to moltenly entirely in the water-bath, use the monolayer filtered through gauze while hot, put and slowly add PEG after cold, stir after the thickening as substrate.Borneolum Syntheticum is dissolved in 5mL ethanol, acetone mixed liquor, standby.The carbomer ointment is added in the PVA substrate, stir; Slowly add Borneolum Syntheticum solution again, add ethanol acetone mixed liquor to full dose, and constantly stir, separate out, stir, promptly to prevent PVA.
Embodiment 11
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 50.0mg,
Adjuvant: Polyethylene Glycol (PEG) 0.5mg, polyvinyl alcohol (PVA) 0.5mg, carbomer 6.0mg, Oleum Anisi Stellati 0.3ml, Oleum Caryophylli 0.3ml.
Method for making is with embodiment 10.
Embodiment 12
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 60.0mg,
Adjuvant: Polyethylene Glycol (PEG) 0.8mg, polyvinyl alcohol (PVA) 10.0mg, carbomer 10.0mg, Oleum Anisi Stellati 10.0ml, Oleum Caryophylli 10.0ml.
Method for making is with embodiment 10.
Embodiment 13
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 10.0mg,
Adjuvant: with calcium alginate gel 0.01mg, poly-newborn ester (PLA) 0.01mg, starch 0.005mg, syrup 0.01mg, aqueous glucose 0.1mg, agar 0.01mg, Borneolum Syntheticum 1.0mg, Camphora 0.1mg, azone 0.01mg, Herba Urticae Cannabinae extract 0.01g, Oleum Anisi Stellati 1.0ml, Oleum Caryophylli 1.0ml, Oleum Curcumae 1.0ml, inferior cus-cus extract 0.01g mix homogeneously, add the Radix aconiti szechenyiani alkaloid, stir, make gel promptly by the high pressure breast is even.
Embodiment 14
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 30.0mg,
Adjuvant: with calcium alginate gel 0.8mg, poly-newborn ester (PLA) 5mg, starch 0.1g, syrup 0.2g, aqueous glucose 0.4g, agar 0.4mg, Borneolum Syntheticum 5.0mg, Camphora 0.6mg, azone 0.1mg, Herba Urticae Cannabinae extract 8.0mg, Oleum Anisi Stellati 0.7ml, Oleum Caryophylli 0.2ml, Oleum Curcumae 0.4ml, inferior cus-cus extract 0.3mg mix homogeneously, add the Radix aconiti szechenyiani alkaloid, stir, make gel promptly by the high pressure breast is even.
Embodiment 15
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 60.0mg,
Adjuvant: with calcium alginate gel 10.0mg, poly-newborn ester (PLA) 10.0mg, starch 10.0mg, syrup 0.8g, aqueous glucose 1.0g, agar 10.0mg, Borneolum Syntheticum 10.0mg, Camphora 10.0mg, azone 10.0mg, Herba Urticae Cannabinae extract 10.0mg, Oleum Anisi Stellati 2.0ml, Oleum Caryophylli 2.0ml, Oleum Curcumae 3.0ml, inferior cus-cus extract 10.0mg mix homogeneously, add the Radix aconiti szechenyiani alkaloid, the high pressure breast is even makes gel promptly.
Embodiment 16
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 6.0mg,
Adjuvant: with Herba Urticae Cannabinae extract 5.0mg, inferior cus-cus extract 6.0mg mix homogeneously, add Radix aconiti szechenyiani alkaloid and water for injection, stir, filter, packing, sterilization, promptly.
Embodiment 17
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 60.0mg,
Adjuvant: with Herba Urticae Cannabinae extract 10.0mg, inferior cus-cus extract 10.0mg mix homogeneously, add Radix aconiti szechenyiani alkaloid and water for injection, stir, filter, packing, sterilization, promptly.
Embodiment 18
Main Ingredients and Appearance: Radix aconiti szechenyiani alkaloid (in aconitine) 50.0mg,
Adjuvant: with Herba Urticae Cannabinae extract 8.0mg, inferior cus-cus extract 5.0mg mix homogeneously, add Radix aconiti szechenyiani alkaloid and water for injection, stir, filter, packing, sterilization, promptly.
Claims (6)
1. analgesic aconitum flavum is characterized in that this time medicine is is slow releasing tablet, slow releasing capsule, gel, local injection liquid and external that principal agent the is made cream of filming by the Radix aconiti szechenyiani alkaloid.
2. according to the described a kind of analgesic aconitum flavum of claim 1, it is characterized in that the prescription of described slow releasing tablet is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: ethyl cellulose 0.01～0.5g;
Methylcellulose 0.01～0.6g;
Herba Urticae Cannabinae extract 0.02～5.0mg;
Borneolum Syntheticum 0.01～0.5g;
Syrup 0.01～0.5ml.
3. according to the described a kind of analgesic aconitum flavum of claim 1, it is characterized in that the prescription of described slow releasing capsule is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: Polyethylene Glycol 0.01～10.0g;
Cellulose acetate 0.01～10.0g;
Phosphatidylcholine 0.01～10.0g;
Gelatin 0.01～10.0g;
Herba Urticae Cannabinae extract 0.01～10.0mg;
Borneolum Syntheticum 0.01～0.8g.
4. according to the described a kind of analgesic aconitum flavum of claim 1, it is characterized in that the prescription of described slow releasing tablet is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: calcium alginate gel 0.01～0.5g;
Poly-butterfat 0.01～10.0g;
Starch 0.005～10.0g;
Cellulose acetate 0.01～10.0g;
Inferior cus-cus extract 0.01～58.0mg;
Herba Urticae Cannabinae extract 0.01～10.0mg;
Borneolum Syntheticum 0.01～10.0g;
Arabic gum 0.001～0.5g.
5. according to the described a kind of analgesic aconitum flavum of claim 1, it is characterized in that the film prescription of cream of described external is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: Polyethylene Glycol 0.01～2.8g;
Polyvinyl alcohol 0.01～10.0g;
Carbomer 0.01～10.0g;
Borneolum Syntheticum 0.01～10.0g;
Camphora 0.01～10.0g;
Azone 0.001～10.0ml;
Oleum Anisi Stellati 0.01～10.0ml;
Oleum Caryophylli 0.01～10.0ml.
6. return medicine according to the described a kind of Radix aconiti szechenyiani pain relieving slow release of claim 1, it is characterized in that the prescription of described gel is:
Principal agent: the Radix aconiti szechenyiani alkaloid, in aconitine 0.10～60.00mg;
Adjuvant: calcium alginate gel 0.01～10.0g;
Poly-butterfat 0.01～10.0ml;
Starch 0.005～10.0g;
Agar 0.01～10.0g;
Borneolum Syntheticum 0.01～10.0g;
Camphora 0.01～10.0g;
Azone 0.001～10.0ml;
Herba Urticae Cannabinae extract 0.01～10.0mg;
Oleum Anisi Stellati 0.01～10.0ml;
Oleum Caryophylli 0.01～10.0ml;
Oleum Curcumae 0.01～10.0ml;
Inferior cus-cus extract 0.01～10.0mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710100738 CN101036681A (en) | 2007-04-11 | 2007-04-11 | Analgesic aconitum flavum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710100738 CN101036681A (en) | 2007-04-11 | 2007-04-11 | Analgesic aconitum flavum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101036681A true CN101036681A (en) | 2007-09-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200710100738 Pending CN101036681A (en) | 2007-04-11 | 2007-04-11 | Analgesic aconitum flavum |
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| CN (1) | CN101036681A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390961B (en) * | 2008-10-31 | 2010-12-15 | 宁夏医科大学 | Medicine composition of aconitum pendulum non-alkaloids active site and preparation method thereof |
| CN110079405A (en) * | 2019-05-10 | 2019-08-02 | 陈硕 | It is a kind of to have effects that alleviate rheumatic arthritis and soap of Chinese medicine promoting blood circulation and removing obstruction in channels and preparation method thereof |
-
2007
- 2007-04-11 CN CN 200710100738 patent/CN101036681A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390961B (en) * | 2008-10-31 | 2010-12-15 | 宁夏医科大学 | Medicine composition of aconitum pendulum non-alkaloids active site and preparation method thereof |
| CN110079405A (en) * | 2019-05-10 | 2019-08-02 | 陈硕 | It is a kind of to have effects that alleviate rheumatic arthritis and soap of Chinese medicine promoting blood circulation and removing obstruction in channels and preparation method thereof |
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Application publication date: 20070919 |