CN105920294A - Traditional Chinese medicine composition for treating diabetes and its preparation method and use - Google Patents

Traditional Chinese medicine composition for treating diabetes and its preparation method and use Download PDF

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CN105920294A
CN105920294A CN201610275051.4A CN201610275051A CN105920294A CN 105920294 A CN105920294 A CN 105920294A CN 201610275051 A CN201610275051 A CN 201610275051A CN 105920294 A CN105920294 A CN 105920294A
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parts
radix
ethanol
chinese medicine
medicine composition
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姜华
胡君茹
詹文强
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Gansu Academy Of Traditional Chinese Medicine Sciences And Technology
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Gansu Academy Of Traditional Chinese Medicine Sciences And Technology
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Abstract

The invention provides a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition is prepared from 20-40 parts by mass of radix astragali, 15-30 parts by mass of ginseng, 20-40 parts by mass of root of kudzu vine, 40-50 parts by mass of radix asparagi, 10-25 parts by mass of red sage root, 20-30 parts by mass of anemarrhena, 15-30 parts by mass of fruits of Chinese magnoliavine, 10-20 parts by mass of rhizoma atractylodis, 15-30 parts by mass of semen astragali complanati and 15-30 parts by mass of trichosanthes root. The invention provides a preparation method and a use of the traditional Chinese medicine composition. The solid particles effectively prevent mildew, guarantee finished product quality and prolong a storage life. At the normal temperature, in three years, bacterium growth, hardening and deterioration are avoided. The traditional Chinese medicine composition has economic and environmental protection values. The traditional Chinese medicine composition realizes discarding of the dross and selection of the essential and improves active ingredient content of unit weight of the drug. The traditional Chinese medicine composition has good treating effects on diabetes, has small side effect and has high safety.

Description

A kind of Chinese medicine composition treating diabetes and its preparation method and application
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine composition treating diabetes and preparation side thereof Method and application.
Background technology
Diabetes are a kind of common, multiple endocrine metabolism diseases, a height of with sickness rate, disability rate and complication Its distinguishing feature, has become as the disease of the third-largest serious threat human health after cardiovascular, tumor.Western medicine blood sugar lowering is made With prominent, but there are certain limitation and untoward reaction, serious untoward reaction even occur, as caused in hypoglycemia, lactic acid Poison etc..Chinese medicine has the advantage of oneself uniqueness in terms for the treatment of diabetes, and it is not only to reduce blood glucose, it is often more important that logical Cross the groups such as the method comprehensive function of integrally-regulated human body of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the overall blood vessel elasticity that recovers, the increase heart, liver, kidney, retina Knit nutrient flow amount, to release patient clinical symptom, prevent and treat multiple chronic complicating diseases, extend the life-span of diabetics.This Outward, Diabetes Mellitus Treated With Traditional Chinese Medicine toxic and side effects is little, and safety is high, has the irreplaceable advantage of chemical synthetic drug.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of Chinese medicine composition treating diabetes, Side effect is little, and safety is high；To this end, the present invention also provides for the preparation method and application of this Chinese medicine composition.
First purpose of the present invention is to provide a kind of Chinese medicine composition treating diabetes, described Chinese medicine composition by with The crude drug of lower mass fraction is prepared from: the Radix Astragali 20～40 parts, Radix Ginseng 15～30 parts, Radix Puerariae 20～40 parts, Radix Asparagi 40～ 50 parts, Radix Salviae Miltiorrhizae 10～25 parts, the Rhizoma Anemarrhenae 20～30 parts, Fructus Schisandrae Chinensis 15～30 parts, Rhizoma Atractylodis 10～20 parts, Semen Astragali Complanati 15～30 parts, Radix Trichosanthis 15～30 parts.
Second object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition, and step is as follows:
(1) according to following weight parts, crude drug is weighed: the Radix Astragali 20～40 parts, Radix Ginseng 15～30 parts, Radix Puerariae 20～40 Part, Radix Asparagi 40～50 parts, Radix Salviae Miltiorrhizae 10～25 parts, the Rhizoma Anemarrhenae 20～30 parts, Fructus Schisandrae Chinensis 15～30 parts, Rhizoma Atractylodis 10～20 parts, husky Garden 15～30 parts, Radix Trichosanthis 15～30 parts；
(2) Radix Ginseng powder is broken into fine powder；As preferably, cross 80～120 mesh sieves afterwards；
(3) Rhizoma Atractylodis are used extraction by steam distillation volatile oil, obtain A；By precipitate with ethanol after the mother liquor concentrations of extraction volatile oil, take supernatant Liquid B；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil A in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges Mixture, carries out precipitate with ethanol, obtains alcohol extract C；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, then precipitate with ethanol after first water concentration contracting, obtain extracting solution D；
(6) described extracting solution B, C, D being merged, concentration and recovery ethanol, concentration process adding Radix Ginseng powder, until obtaining extractum E；
(7) by volatile oil A beta-cyclodextrin inclusion compound, Benexate Hydrochloride F is obtained；
(8) extractum E, adjuvant are added Benexate Hydrochloride F, pelletize after mixing, be drying to obtain.
As preferably, in step (3), the preparation method of volatile oil A is that Rhizoma Atractylodis add its weight 8～10 times of water, steams by water Steam distillation method extracts volatile oil 4～6 hours；
As preferably, described in step (3), the preparation method of supernatant B is: will extract the mother liquor concentrations of volatile oil to medical material: medicine Liquid=1:1, and carrying out precipitate with ethanol with the ethanol of 2 times amount 75%～95%, precipitate with ethanol temperature is 40 DEG C～60 DEG C, stands 16～24 hours.
As preferably, precipitate with ethanol described in step (4) is that the ethanol adding weight 10～15 times in the mixture carries out alcohol extraction, Alcohol extraction process: 55～the ethanol extraction 2 of 75%～3 times, each 1.0～1.5 hours.
As preferably, water described in step (5) carries the water being to add 10～15 times of weight in the mixture, is 95 in temperature ～decoction 2～4 times at 100 DEG C, each 1.0～1.5 hours；
As preferably, precipitate with ethanol described in step (5) is 2 times 75%～the ethanol of 95% of addition, precipitate with ethanol temperature in water extracting liquid It is 40～50 DEG C, stands 16～24 hours, take supernatant.
As preferably, described in step (7) by volatile oil A beta-cyclodextrin inclusion compound be by volatile oil A, beta-schardinger dextrin-and Water mixes, and stirs 2 hours, inclusion temperature 50 C, obtains clathrate；Described beta-schardinger dextrin-: water=1: 2～5(W/W), volatile oil A : beta-schardinger dextrin-=1: 2～8(W/W).
As preferably, described in step (8), the ratio of extractum E and adjuvant is 1:1～2.5(W/W).
Third object of the present invention is to provide the application in the medicine of preparation treatment diabetes of the above-mentioned Chinese medicine composition.
Fourth object of the present invention is to provide a kind of medicine, and the effective ingredient of described medicine is described in claim 1 Chinese medicine composition.
As preferably, the dosage form of described medicine is granule；
As preferably, described medicine also includes medically acceptable adjuvant.
The prescription of the Chinese medicine composition of the present invention is according to being:
The name " quenched one's thirst ", head sees " The Yellow Emperor's Canon of Internal Medicine ": " the soft weak person of the five internal organs, kind sick diseases due to endogenous heat of ZANG FU organs "." ... over-eating the food with sweet flavor bringing about abdominal distension, therefore its Gas overflow, transfers to and quenching one's thirst "." Standards of Diagnosis and Treatment diseases due to endogenous heat of ZANG FU organs ": " thirsty and polydipsia disappears on being, rapid digestion of food and polyorexia disappears in being, number has cream yearningly and just Disappear under for ".In treatment, " Medicine Comprehended. three disappear ": " control the suitable lung moistening of the person of disappearing, its stomach clear of holding concurrently；In controlling, the person's of disappearing its stomach preferably clear, holds concurrently Grow its kidney；Control the inferior the person of disappearing and preferably grow its kidney, hold concurrently and mend its lung." the preparation prescription medicine accordingly of the present invention.Prescription herbal function is analyzed:
The Radix Astragali: benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting.There is enhancing and regulation body's immunity, have dual modulation blood Sugar, and blood circulation promoting, improve microcirculatory effect.
Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind.Saponin and polysaccharide in Radix Ginseng can improve islets of langerhans Element opposing, assistant hypoglycemic and tune fat, have clearly bi-directional regulation effect to the blood glucose regulation of people.
Radix Puerariae: yang invigorating is brought down a fever, promoting the production of body fluid to quench thirst.Radix Puerariae active component puerarin is while the secretion of glucagon suppression Promote the secretion of insulin, it is possible to the blood vessel of activation diabetes patient, vessel softening wall, increase the elasticity of smooth muscle, reduce blood vessel Resistance, strengthens blood flow rate, reduces intravascular mass deposition, improves blood circulation.
Radix Asparagi: nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.There is stabilizing blood pressure, reduce cholesterol, blood glucose and the effect such as antibacterial；And have stronger The effect removing superoxide radical, thus reduce the generation of atherosclerosis, tumor.
Radix Salviae Miltiorrhizae: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.Myocardial ischemia can be improved, regulate the rhythm of the heart；Expansion peripheral blood vessel, Improve microcirculation；Improve body's hypoxia tolerance；Anticoagulation, promotes fibrinolytic, suppresses platelet aggregation, inhibition thrombosis；Fall Hypolipemia, suppression coronary atherosclerosis is formed.
The Rhizoma Anemarrhenae: clearing away heat-fire, Yin-nourishing and body fluid promoting, moisturize and quench one's thirst.Its water extract and polysaccharide have hypoglycemic activity, phonetic to four oxygen Pyridine causes diabetic rabbit, mice and insulin antiserum cause diabetic mice more obvious hypoglycemic activity.
Fructus Schisandrae Chinensis: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.There is protection and strengthen heart body, strengthen human immunity Power and build up one's resistance to disease, free radical resisting, delaying aging, nourish and strengthen the effect such as kidney function.
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.The Radix Astragali, Radix Ginseng, Fructus Schisandrae Chinensis etc. grow lung kidney tonifying, and big QI invigorating is cloudy, hence it is evident that Improve hypoglycemic synergism.
Semen Astragali Complanati: tonifying liver, kidney tonifying, improving eyesight, controlling nocturnal emission with astringent drugs.Liver glycogen can be protected to accumulate, blood fat reducing, fall enzyme；Energy decreased heart rate, fall Hypotension, increases cerebral blood flow；Hemorheology index can be improved, suppress platelet aggregation；Energy enhancing human body immunity power, improves Body specificity and non-specific immunity.
Radix Trichosanthis: clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus is subsided a swelling.Treatment calentura is thirsty, polydipsia of quenching one's thirst, lung-heat type cough, skin infection Toxic swelling.
All medicines close 5, have nourishing kidney-YIN, promoting the production of body fluid to quench thirst, dispel diarrhea of heat type fire, effect of kidney tonifying reducing urination.For treat polydipsia, Polyuria, polyphagia, become thin, fatigue and lack of strength, dormancy difference lumbago, glucose in urine and blood glucose raise.
The advantage of the Chinese medicine composition of the present invention is as follows:
(1) in the prior art, preparation is to be applied to clinic with capsule, and technique is: prescription drugs is ground into fine powder, sieves, Mixing, loads capsule, to obtain final product.Owing to Chinese prescription is entirely crude drug powder, when condition is suitable, the microorganism in medicine will be grown Length and breeding, cause moldy metamorphism.The solid particle agent that the present invention develops, extracts Chinese crude drug, efficiently avoid mould The phenomenons such as change, thus there is the characteristic of " safety, health ", it is ensured that end product quality extends the pot-life simultaneously.Room temperature is nothing in lower 3 years Long bacterium, harden and the phenomenon such as go bad, there is value economical and environmentally friendly.
(2) prior art is to use crude drug directly to apply, and active constituent content is low, affects drug effect.The present invention is directed to existing Processing method improve, medical material is used water extraction, alcohol extraction, ethanol precipitation, both with water extraction go out alkaloid salt, The effective ingredient such as glycoside, organic acid, aminoacid, again with ethanol by change dissolubility and by tannin, resin, fat-soluble pigment Remove with the impurity such as protein, accomplished to discard the dross and select the essential so that effective ingredient contained by the medicine of Unit Weight is improved, this Medicine prepared by bright technique, its medicine effective content daily is the 8～12 of the medicine effective content of prior art processing Times, the curative effect of clinical medicine application increases substantially.
(3) due in prescription of the present invention Rhizoma Atractylodis contain volatile oil, volatile oil temperature higher than 60 DEG C time readily volatilized, decocting Boiling temperature and reach 100 DEG C, volatile ingredient scatters and disappears the most in a large number, makes prescription lose original effect, and due to this kind of material Being soluble in low polar organic solvent, and dissolubility is less in water, therefore, extraction process first uses steam distillation to be waved The property sent out constituents extraction, afterwards, retains its mother solution, has both made volatile oil effectively obtain, extract the most completely time again by extraction Water-soluble substances retained.
(4) present invention uses beta-cyclodextrin inclusion compound technology that volatile oil is carried out inclusion, medicine by inclusion in molecular capsule In, release can be controlled, reduce zest and side effect, reduce volatilization, make liquid drug powdered, and beta-schardinger dextrin-is carbon Hydrate can be absorbed by the body utilization without cumulative action.
(5) Chinese medicine composition of the present invention is good to the therapeutic effect of diabetes, and side effect is little, and safety is high.
Detailed description of the invention
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiment Method, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is city Sell.
The Traditional Chinese medicine composition formula of the treatment diabetes of the present invention is as follows:
The Radix Astragali 20～40g, Radix Ginseng 15～30g, Radix Puerariae 20～40g, Radix Asparagi 40～50g, Radix Salviae Miltiorrhizae 10～25g, the Rhizoma Anemarrhenae 20～ 30g, Fructus Schisandrae Chinensis 15～30g, Rhizoma Atractylodis 10～20g, Semen Astragali Complanati 15～30g, Radix Trichosanthis 15～30g.
The preparation method of the Chinese medicine composition of the treatment diabetes of the present invention is:
(1) weigh by the former medicine of following weight parts: the Radix Astragali 20～40g, Radix Ginseng 15～30g, Radix Puerariae 20～40g, Radix Asparagi 40 ～50g, Radix Salviae Miltiorrhizae 10～25g, the Rhizoma Anemarrhenae 20～30g, Fructus Schisandrae Chinensis 15～30g, Rhizoma Atractylodis 10～20g, Semen Astragali Complanati 15～30g, variola Powder 15～30g；
(2) Radix Ginseng powder is broken into fine powder, crosses 80～120 mesh sieves, standby；
(3) Rhizoma Atractylodis are added its weight 8～10 times of water, by extraction by steam distillation volatile oil 4～6 hours, the volatilization of collection Oil is A, airtight preservation, collects medicinal residues.The mother liquor concentrations of volatile oil will be extracted to medical material: medicinal liquid=1:1(W/W), (concentrate with 2 times Liquid v/v) to measure the ethanol of 75%～95% and carry out precipitate with ethanol, precipitate with ethanol temperature is 40 DEG C～60 DEG C, stands 16～24 hours, and taking supernatant is B, standby；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges, adds The ethanol entering its weight 10～15 times carries out alcohol extraction (alcohol extraction process: 55～the ethanol extraction 2 of 75%～3 times, each 1.0～1.5 Hour) merging alcohol extract is C, standby；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, add water by the 10～15 of its mixture weight times, Decoct at temperature is 95～100 DEG C 2～4 times, each 1.0～1.5 hours, merge Aqueous extracts, be concentrated into medicinal liquid: medical material=1:1 (W/W) time, carrying out precipitate with ethanol, precipitate with ethanol condition is the ethanol of 2 times of (concentrated solution v/v) 75%～95%, and precipitate with ethanol temperature is 40～50 DEG C, Stand 16～24 hours, take supernatant, obtain extracting solution D, standby；
(6) described extracting solution B, C, D are merged, concentration and recovery ethanol at a temperature of 80～90 DEG C, concentration process adds Radix Ginseng Powder, until obtaining the extractum E that proportion is 1.25～1.30；
(7) volatile oil A is used beta-cyclodextrin inclusion compound: beta-schardinger dextrin-: water=1: 2～5(W/W), volatile oil A: beta-schardinger dextrin-= 1: 2～8(W/W), stirring 2 hours, inclusion temperature 50 C, leach inclusion complex, 40 DEG C～60 DEG C are dried to obtain Benexate Hydrochloride F；
(8) by extractum E, adjuvant (lactose: dextrin: aspartame: magnesium stearate=1: 2～3: 0.5%～2%: 0.1%～0.3%)= 1:1～2.5(W/W), add Benexate Hydrochloride F, mixing, dry-pressing or wet granulation, be dried to perseverance through 50～70 DEG C After Chong, granulate and get final product.
The usage and dosage of the Chinese medicine composition of the treatment diabetes of the present invention: oral, a 20g, 2 times on the one.
Embodiment 1
The Traditional Chinese medicine composition formula of the treatment diabetes of the present invention is as follows:
Radix Astragali 30g, Radix Ginseng 20g, Radix Puerariae 30g, Radix Asparagi 45g, Radix Salviae Miltiorrhizae 15g, Rhizoma Anemarrhenae 25g, Fructus Schisandrae Chinensis 20g, Rhizoma Atractylodis 15g, Semen Astragali Complanati 20g, Radix Trichosanthis 20g.
The preparation method of the Chinese medicine composition of the treatment diabetes of the present invention is:
(1) weigh by the former medicine of following weight parts: Radix Astragali 30g, Radix Ginseng 20g, Radix Puerariae 30g, Radix Asparagi 45g, Radix Salviae Miltiorrhizae 15g, Rhizoma Anemarrhenae 25g, Fructus Schisandrae Chinensis 20g, Rhizoma Atractylodis 15g, Semen Astragali Complanati 20g, Radix Trichosanthis 20g；
(2) Radix Ginseng powder is broken into fine powder, crosses 100 mesh sieves, standby；
(3) Rhizoma Atractylodis add 9 times of water of its weight, and by extraction by steam distillation volatile oil 5 hours, the volatile oil of collection was A, close Close preservation, collect medicinal residues.The mother liquor concentrations of volatile oil will be extracted to medical material: medicinal liquid=1:1(W/W), measure with 2 times (concentrated solution v/v) The ethanol of 85% carries out precipitate with ethanol, and precipitate with ethanol temperature is 50 DEG C, stands 20 hours, and taking supernatant is B, standby；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges, adds Enter the ethanol of its weight 12 times and carry out alcohol extraction (alcohol extraction process: the ethanol extraction of 65% 2 times, each 1.2 hours) and merge alcohol extract and be C, standby；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, add water by the 12 of its mixture weight times, in temperature Degree is to decoct at 98 DEG C 3 times, each 1.2 hours, merges Aqueous extracts, is concentrated into medicinal liquid: medical material=1:1(W/W) time, carry out precipitate with ethanol, Precipitate with ethanol condition is the ethanol of 2 times of (concentrated solution v/v) 85%, and precipitate with ethanol temperature is 45 DEG C, stands 20 hours, takes supernatant, carried Take liquid D, standby；
(6) described extracting solution B, C, D are merged, concentration and recovery ethanol at a temperature of 85 DEG C, concentration process adds Radix Ginseng powder, directly To obtaining the extractum E that proportion is 1.28；
(7) volatile oil A is used beta-cyclodextrin inclusion compound: beta-schardinger dextrin-: water=1: 4(W/W), volatile oil A: beta-schardinger dextrin-=1: 4 (W/W), stirring 2 hours, inclusion temperature 50 C, leach inclusion complex, 50 DEG C are dried to obtain Benexate Hydrochloride F；
(8) by extractum E, adjuvant (lactose: dextrin: aspartame: magnesium stearate=1: 2.5: 1%: 0.2%)=1:1.5(W/W), add Enter Benexate Hydrochloride F, mixing, dry-pressing or wet granulation, it is dried to constant weight through 60 DEG C, granulate and get final product.
The usage and dosage of the Chinese medicine composition of the treatment diabetes of the present invention: oral, a 20g, 2 times on the one.
Embodiment 2
The Traditional Chinese medicine composition formula of the treatment diabetes of the present invention is as follows:
Radix Astragali 40g, Radix Ginseng 30g, Radix Puerariae 40g, Radix Asparagi 40g, Radix Salviae Miltiorrhizae 10g, Rhizoma Anemarrhenae 20g, Fructus Schisandrae Chinensis 30g, Rhizoma Atractylodis 20g, husky The sub-30g in garden, Radix Trichosanthis 15g.
The preparation method of the Chinese medicine composition of the treatment diabetes of the present invention is:
(1) weigh by the former medicine of following weight parts: Radix Astragali 40g, Radix Ginseng 30g, Radix Puerariae 40g, Radix Asparagi 40g, Radix Salviae Miltiorrhizae 10g, know Female 20g, Fructus Schisandrae Chinensis 30g, Rhizoma Atractylodis 20g, Semen Astragali Complanati 30g, Radix Trichosanthis 15g；
(2) Radix Ginseng powder is broken into fine powder, crosses 120 mesh sieves, standby；
(3) Rhizoma Atractylodis add 8 times of water of its weight, and by extraction by steam distillation volatile oil 4 hours, the volatile oil of collection was A, close Close preservation, collect medicinal residues.The mother liquor concentrations of volatile oil will be extracted to medical material: medicinal liquid=1:1(W/W), measure with 2 times (concentrated solution v/v) The ethanol of 95% carries out precipitate with ethanol, and precipitate with ethanol temperature is 40 DEG C, stands 24 hours, and taking supernatant is B, standby；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges, adds Enter the ethanol of its weight 10 times and carry out alcohol extraction (alcohol extraction process: the ethanol extraction of 55% 3 times, each 1.0 hours) and merge alcohol extract and be C, standby；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, add water by the 10 of its mixture weight times, in temperature Degree is to decoct at 95 DEG C 2 times, each 1.0 hours, merges Aqueous extracts, is concentrated into medicinal liquid: medical material=1:1(W/W) time, carry out precipitate with ethanol, Precipitate with ethanol condition is the ethanol of 2 times of (concentrated solution v/v) 75%, and precipitate with ethanol temperature is 40 DEG C, stands 24 hours, takes supernatant, carried Take liquid D, standby；
(6) described extracting solution B, C, D are merged, concentration and recovery ethanol at a temperature of 80 DEG C, concentration process adds Radix Ginseng powder, directly To obtaining the extractum E that proportion is 1.30；
(7) volatile oil A is used beta-cyclodextrin inclusion compound: beta-schardinger dextrin-: water=1: 2(W/W), volatile oil A: beta-schardinger dextrin-=1: 8 (W/W), stirring 2 hours, inclusion temperature 50 C, leach inclusion complex, 40 DEG C are dried to obtain Benexate Hydrochloride F；
(8) by extractum E, adjuvant (lactose: dextrin: aspartame: magnesium stearate=1: 2: 0.5%: 0.3%)=1:2.5(W/W), add Enter Benexate Hydrochloride F, mixing, dry-pressing or wet granulation, it is dried to constant weight through 70 DEG C, granulate and get final product.
The usage and dosage of the Chinese medicine composition of the treatment diabetes of the present invention: oral, a 20g, 2 times on the one.
Embodiment 3
The Traditional Chinese medicine composition formula of the treatment diabetes of the present invention is as follows:
Radix Astragali 20g, Radix Ginseng 15g, Radix Puerariae 20g, Radix Asparagi 50g, Radix Salviae Miltiorrhizae 25g, Rhizoma Anemarrhenae 30g, Fructus Schisandrae Chinensis 15g, Rhizoma Atractylodis 10g, Semen Astragali Complanati 15g, Radix Trichosanthis 30g.
The preparation method of the Chinese medicine composition of the treatment diabetes of the present invention is:
(1) weigh by the former medicine of following weight parts: Radix Astragali 20g, Radix Ginseng 15g, Radix Puerariae 20g, Radix Asparagi 50g, Radix Salviae Miltiorrhizae 25g, the Rhizoma Anemarrhenae 30g, Fructus Schisandrae Chinensis 15g, Rhizoma Atractylodis 10g, Semen Astragali Complanati 15g, Radix Trichosanthis 30g；
(2) Radix Ginseng powder is broken into fine powder, crosses 80 mesh sieves, standby；
(3) Rhizoma Atractylodis add 10 times of water of its weight, and by extraction by steam distillation volatile oil 6 hours, the volatile oil of collection was A, Airtight preservation, collects medicinal residues.The mother liquor concentrations of volatile oil will be extracted to medical material: medicinal liquid=1:1(W/W), with 2 times (concentrated solution v/v) The ethanol of amount 75% carries out precipitate with ethanol, and precipitate with ethanol temperature is 60 DEG C, stands 16 hours, and taking supernatant is B, standby；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges, adds Enter the ethanol of its weight 15 times and carry out alcohol extraction (alcohol extraction process: the ethanol extraction of 75% 2 times, each 1.5 hours) and merge alcohol extract and be C, standby；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, add water by the 15 of its mixture weight times, in temperature Degree is to decoct at 100 DEG C 4 times, each 1.5 hours, merges Aqueous extracts, is concentrated into medicinal liquid: medical material=1:1(W/W) time, carry out alcohol Heavy, precipitate with ethanol condition is the ethanol of 2 times of (concentrated solution v/v) 95%, and precipitate with ethanol temperature is 50 DEG C, stands 16 hours, takes supernatant, obtain Extracting solution D, standby；
(6) described extracting solution B, C, D are merged, concentration and recovery ethanol at a temperature of 90 DEG C, concentration process adds Radix Ginseng powder, directly To obtaining the extractum E that proportion is 1.25；
(7) volatile oil A is used beta-cyclodextrin inclusion compound: beta-schardinger dextrin-: water=1: 5(W/W), volatile oil A: beta-schardinger dextrin-=1: 2 (W/W), stirring 2 hours, inclusion temperature 50 C, leach inclusion complex, 60 DEG C are dried to obtain Benexate Hydrochloride F；
(8) by extractum E, adjuvant (lactose: dextrin: aspartame: magnesium stearate=1: 3: 2%: 0.1%)=1:1(W/W), addition β- Cyclodextrin clathrate F, mixing, dry-pressing or wet granulation, it is dried to constant weight through 50 DEG C, granulate and get final product.
The usage and dosage of the Chinese medicine composition of the treatment diabetes of the present invention: oral, a 20g, 2 times on the one.
Embodiment 4
The Traditional Chinese medicine composition formula of the treatment diabetes of the present invention is as follows:
Radix Astragali 25g, Radix Ginseng 25g, Radix Puerariae 25g, Radix Asparagi 45g, Radix Salviae Miltiorrhizae 18g, Rhizoma Anemarrhenae 26g, Fructus Schisandrae Chinensis 25g, Rhizoma Atractylodis 18g, Semen Astragali Complanati 25g, Radix Trichosanthis 18g.
The preparation method of the Chinese medicine composition of the treatment diabetes of the present invention is:
(1) weigh by the former medicine of following weight parts: Radix Astragali 25g, Radix Ginseng 25g, Radix Puerariae 25g, Radix Asparagi 45g, Radix Salviae Miltiorrhizae 18g, the Rhizoma Anemarrhenae 26g, Fructus Schisandrae Chinensis 25g, Rhizoma Atractylodis 18g, Semen Astragali Complanati 25g, Radix Trichosanthis 18g；
(2) Radix Ginseng powder is broken into fine powder, crosses 90 mesh sieves, standby；
(3) Rhizoma Atractylodis add 10 times of water of its weight, and by extraction by steam distillation volatile oil 5 hours, the volatile oil of collection was A, Airtight preservation, collects medicinal residues.The mother liquor concentrations of volatile oil will be extracted to medical material: medicinal liquid=1:1(W/W), with 2 times (concentrated solution v/v) The ethanol of amount 80% carries out precipitate with ethanol, and precipitate with ethanol temperature is 45 DEG C, stands 18 hours, and taking supernatant is B, standby；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges, adds Enter the ethanol of its weight 14 times and carry out alcohol extraction (alcohol extraction process: the ethanol extraction of 75% 2 times, each 1.5 hours) and merge alcohol extract and be C, standby；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, add water by the 13 of its mixture weight times, in temperature Degree is to decoct at 99 DEG C 4 times, each 1.0 hours, merges Aqueous extracts, is concentrated into medicinal liquid: medical material=1:1(W/W) time, carry out precipitate with ethanol, Precipitate with ethanol condition is the ethanol of 2 times of (concentrated solution v/v) 90%, and precipitate with ethanol temperature is 48 DEG C, stands 18 hours, takes supernatant, carried Take liquid D, standby；
(6) described extracting solution B, C, D are merged, concentration and recovery ethanol at a temperature of 88 DEG C, concentration process adds Radix Ginseng powder, directly To obtaining the extractum E that proportion is 1.26；
(7) volatile oil A is used beta-cyclodextrin inclusion compound: beta-schardinger dextrin-: water=1: 4(W/W), volatile oil A: beta-schardinger dextrin-=1: 7 (W/W), stirring 2 hours, inclusion temperature 50 C, leach inclusion complex, 55 DEG C are dried to obtain Benexate Hydrochloride F；
(8) by extractum E, adjuvant (lactose: dextrin: aspartame: magnesium stearate=1: 2.3: 1.2%: 0.1%)=1:1.8(W/W), Add Benexate Hydrochloride F, mixing, dry-pressing or wet granulation, be dried to constant weight through 50 DEG C, granulate and get final product.
The usage and dosage of the Chinese medicine composition of the treatment diabetes of the present invention: oral, a 20g, 2 times on the one.
Embodiment 5
The Traditional Chinese medicine composition formula of the treatment diabetes of the present invention is as follows:
Radix Astragali 35g, Radix Ginseng 23g, Radix Puerariae 35g, Radix Asparagi 43g, Radix Salviae Miltiorrhizae 13g, Rhizoma Anemarrhenae 23g, Fructus Schisandrae Chinensis 18g, Rhizoma Atractylodis 18g, Semen Astragali Complanati 21g, Radix Trichosanthis 21g.
The preparation method of the Chinese medicine composition of the treatment diabetes of the present invention is:
(1) weigh by the former medicine of following weight parts: Radix Astragali 35g, Radix Ginseng 23g, Radix Puerariae 35g, Radix Asparagi 43g, Radix Salviae Miltiorrhizae 13g, the Rhizoma Anemarrhenae 23g, Fructus Schisandrae Chinensis 18g, Rhizoma Atractylodis 18g, Semen Astragali Complanati 21g, Radix Trichosanthis 21g；
(2) Radix Ginseng powder is broken into fine powder, crosses 110 mesh sieves, standby；
(3) Rhizoma Atractylodis add 10 times of water of its weight, and by extraction by steam distillation volatile oil 4 hours, the volatile oil of collection was A, Airtight preservation, collects medicinal residues.The mother liquor concentrations of volatile oil will be extracted to medical material: medicinal liquid=1:1(W/W), with 2 times (concentrated solution v/v) The ethanol of amount 85% carries out precipitate with ethanol, and precipitate with ethanol temperature is 55 DEG C, stands 22 hours, and taking supernatant is B, standby；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges, adds Enter the ethanol of its weight 11 times and carry out alcohol extraction (alcohol extraction process: the ethanol extraction of 65% 2 times, each 1.5 hours) and merge alcohol extract and be C, standby；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, add water by the 14 of its mixture weight times, in temperature Degree is to decoct at 97 DEG C 4 times, each 1.5 hours, merges Aqueous extracts, is concentrated into medicinal liquid: medical material=1:1(W/W) time, carry out precipitate with ethanol, Precipitate with ethanol condition is the ethanol of 2 times of (concentrated solution v/v) 90%, and precipitate with ethanol temperature is 40 DEG C, stands 20 hours, takes supernatant, carried Take liquid D, standby；
(6) described extracting solution B, C, D are merged, concentration and recovery ethanol at a temperature of 82 DEG C, concentration process adds Radix Ginseng powder, directly To obtaining the extractum E that proportion is 1.28；
(7) volatile oil A is used beta-cyclodextrin inclusion compound: beta-schardinger dextrin-: water=1: 3(W/W), volatile oil A: beta-schardinger dextrin-=1: 4 (W/W), stirring 2 hours, inclusion temperature 50 C, leach inclusion complex, 45 DEG C are dried to obtain Benexate Hydrochloride F；
(8) by extractum E, adjuvant (lactose: dextrin: aspartame: magnesium stearate=1: 2.6: 1.5%: 0.2%)=1:1.6(W/W), Add Benexate Hydrochloride F, mixing, dry-pressing or wet granulation, be dried to constant weight through 55 DEG C, granulate and get final product.
The usage and dosage of the Chinese medicine composition of the treatment diabetes of the present invention: oral, a 20g, 2 times on the one.
The treatment embodiment of the Chinese medicine composition of embodiment 6 present invention
(1) case selection: select 60 Diabetic Patients, male 27 example, women 33 example, age 22～62 years old, the course of disease 1～6 years.
(2) inclusive criteria: Western medicine diagnose standard is diagnosed as II type glycosuria according to the World Health Organization (WHO) in 1999 Sick；Syndrome Differentiation of Traditional Chinese Medicine standard is former with reference to the guidance of diabetes in Ministry of Public Health 2002 " new Chinese medicine guideline of clinical investigations " Then, dialectical for type of deficiency of both QI and YIN.Primary symptom is dry mouth and throat, fatigue and weakness；Secondary disease is polyorexia, thirst and liking drink, lazyness of breathing hard Speech, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, red constipation of urinating, red tongue with a little fluid thin fur or flower stripping, thready and rapid pulse without strength or carefully string.All cases All get rid of hepatic and kidney function obstacle, type Ⅰ diabetes mellitus, tumor, disease of hematopoietic system and psychosis, severe arrhythmia, acute mental and physical efforts Exhaustion or chronic cardiac insufficiency more than 3 grades.
(3) Therapeutic Method: oral, a 20g, 2 times on the one, rule of life during treatment, keep in high spirits, diet Pungent, sweet taste and greasy food, give up habits of smoking and alcohol drinking.It within one month, it is a course for the treatment of.
(4) therapeutic outcome
4.1 criterions of therapeutical effect: with reference to " new Chinese medicine guideline of clinical investigations ", effective: after treatment, symptom disappears substantially, FBG < 7.12mmol/L, or PBG < 8.13mmol/L；Effective: after treatment, symptom is obviously improved, FBG < 8.13mmol/L, PBG < 10.10mmol/L, blood glucose declines more than 10% before relatively treating；Invalid: after treatment, symptom is not improved, blood glucose does not drops or does not reaches Above-mentioned standard.
4.2 therapeutic outcomes: obvious effective rate 21 example, 35.00%；Effective percentage 34 example, 56.67%；Inefficiency 5 example, 8.33%；Always have Efficiency 55 example, 91.67%.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention, although Being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still can be right Technical scheme described in foregoing embodiments is modified, or wherein portion of techniques feature is carried out equivalent.All Within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the protection of the present invention Within the scope of.

Claims (10)

1. the Chinese medicine composition treating diabetes, it is characterised in that: described Chinese medicine composition is former by following mass fraction Material medicine be prepared from: the Radix Astragali 20～40 parts, Radix Ginseng 15～30 parts, Radix Puerariae 20～40 parts, Radix Asparagi 40～50 parts, Radix Salviae Miltiorrhizae 10～ 25 parts, the Rhizoma Anemarrhenae 20～30 parts, Fructus Schisandrae Chinensis 15～30 parts, Rhizoma Atractylodis 10～20 parts, Semen Astragali Complanati 15～30 parts, Radix Trichosanthis 15～30 Part.
2. the preparation method of the Chinese medicine composition described in claim 1, it is characterised in that: step is as follows:
(1) according to following weight parts, crude drug is weighed: the Radix Astragali 20～40 parts, Radix Ginseng 15～30 parts, Radix Puerariae 20～40 Part, Radix Asparagi 40～50 parts, Radix Salviae Miltiorrhizae 10～25 parts, the Rhizoma Anemarrhenae 20～30 parts, Fructus Schisandrae Chinensis 15～30 parts, Rhizoma Atractylodis 10～20 parts, husky Garden 15～30 parts, Radix Trichosanthis 15～30 parts；
(2) Radix Ginseng powder is broken into fine powder；As preferably, cross 80～120 mesh sieves afterwards；
(3) Rhizoma Atractylodis are used extraction by steam distillation volatile oil, obtain A；By precipitate with ethanol after the mother liquor concentrations of extraction volatile oil, take supernatant Liquid B；
(4) by the Radix Salviae Miltiorrhizae of the medicinal residues after extraction volatile oil A in step (3) with formula ratio, the Rhizoma Anemarrhenae, Fructus Schisandrae Chinensis, Semen Astragali Complanati merges Mixture, carries out precipitate with ethanol, obtains alcohol extract C；
(5) by the Radix Astragali of formula ratio, Radix Puerariae, Radix Asparagi, after Radix Trichosanthis mixing, then precipitate with ethanol after first water concentration contracting, obtain extracting solution D；
(6) described extracting solution B, C, D being merged, concentration and recovery ethanol, concentration process adding Radix Ginseng powder, until obtaining extractum E；
(7) by volatile oil A beta-cyclodextrin inclusion compound, Benexate Hydrochloride F is obtained；
(8) extractum E, adjuvant are added Benexate Hydrochloride F, pelletize after mixing, be drying to obtain.
Method the most according to claim 1, it is characterised in that: in step (3), the preparation method of volatile oil A is to be added by Rhizoma Atractylodis Enter its weight 8～10 times of water, by extraction by steam distillation volatile oil 4～6 hours；
As preferably, described in step (3), the preparation method of supernatant B is: will extract the mother liquor concentrations of volatile oil to medical material: medicine Liquid=1:1, and carrying out precipitate with ethanol with the ethanol of 2 times amount 75%～95%, precipitate with ethanol temperature is 40 DEG C～60 DEG C, stands 16～24 hours.
Method the most according to claim 1, it is characterised in that: precipitate with ethanol described in step (4) is to add weight in the mixture The ethanol measuring 10～15 times carries out alcohol extraction, alcohol extraction process: 55～the ethanol extraction 2 of 75%～3 times, each 1.0～1.5 hours.
Method the most according to claim 1, it is characterised in that: it is to add 10 in the mixture that water described in step (5) carries ～the water of 15 times of weight, decoction 2～4 times at temperature is 95～100 DEG C, each 1.0～1.5 hours；
As preferably, precipitate with ethanol described in step (5) is 2 times 75%～the ethanol of 95% of addition, precipitate with ethanol temperature in water extracting liquid It is 40～50 DEG C, stands 16～24 hours, take supernatant.
Method the most according to claim 1, it is characterised in that: by volatile oil A beta-schardinger dextrin-bag described in step (7) Conjunction is volatile oil A, beta-schardinger dextrin-and water to be mixed, and stirs 2 hours, inclusion temperature 50 C, obtains clathrate；Described β-ring is stuck with paste Essence: water=1: 2～5(W/W), volatile oil A: beta-schardinger dextrin-=1: 2～8(W/W).
Method the most according to claim 1, it is characterised in that: described in step (8), the ratio of extractum E and adjuvant is 1:1 ～2.5(W/W).
8. the application in the medicine of preparation treatment diabetes of the Chinese medicine composition described in claim 1.
9. a medicine, it is characterised in that: the effective ingredient of described medicine is the Chinese medicine composition described in claim 1.
Medicine the most according to claim 9, it is characterised in that: the dosage form of described medicine is granule；As preferably, go back Including medically acceptable adjuvant.
CN201610275051.4A 2016-04-28 2016-04-28 Traditional Chinese medicine composition for treating diabetes and its preparation method and use Pending CN105920294A (en)

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Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1184640A (en) * 1996-12-12 1998-06-17 孙黛娟 Drug for curing diabetes
CN101108225A (en) * 2006-07-17 2008-01-23 吉林益民堂制药有限公司 Diabetes treating capsule dose and technique of preparing the same
CN101590101A (en) * 2008-05-27 2009-12-02 孙民富 A kind of prescription and preparation technology who treats type and complication thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1184640A (en) * 1996-12-12 1998-06-17 孙黛娟 Drug for curing diabetes
CN101108225A (en) * 2006-07-17 2008-01-23 吉林益民堂制药有限公司 Diabetes treating capsule dose and technique of preparing the same
CN101590101A (en) * 2008-05-27 2009-12-02 孙民富 A kind of prescription and preparation technology who treats type and complication thereof

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Application publication date: 20160907