CN105916504B - 用于治疗癌症的组合制剂 - Google Patents

用于治疗癌症的组合制剂 Download PDF

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Publication number
CN105916504B
CN105916504B CN201480073584.3A CN201480073584A CN105916504B CN 105916504 B CN105916504 B CN 105916504B CN 201480073584 A CN201480073584 A CN 201480073584A CN 105916504 B CN105916504 B CN 105916504B
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cancer
lag
imp321
agent
antineoplastic agent
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CN105916504A (zh
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弗雷德里克·特里贝尔
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Immutep SAS
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Immutep SAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201480073584.3A 2013-12-19 2014-12-19 用于治疗癌症的组合制剂 Active CN105916504B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110293412.9A CN112957452A (zh) 2013-12-19 2014-12-19 用于治疗癌症的组合制剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1322626.1 2013-12-19
GBGB1322626.1A GB201322626D0 (en) 2013-12-19 2013-12-19 Combined preparations for the treatment of cancer
PCT/EP2014/078779 WO2015091970A1 (en) 2013-12-19 2014-12-19 Combined preparations for the treatment of cancer

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CN202110293412.9A Division CN112957452A (zh) 2013-12-19 2014-12-19 用于治疗癌症的组合制剂

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CN105916504A CN105916504A (zh) 2016-08-31
CN105916504B true CN105916504B (zh) 2021-03-23

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CN202110293412.9A Pending CN112957452A (zh) 2013-12-19 2014-12-19 用于治疗癌症的组合制剂

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US (3) US10736940B2 (https=)
EP (3) EP4414035A3 (https=)
JP (2) JP6691054B2 (https=)
KR (3) KR102593917B1 (https=)
CN (2) CN105916504B (https=)
AU (1) AU2014368420B2 (https=)
DK (2) DK3089749T3 (https=)
ES (2) ES2730976T3 (https=)
FI (1) FI3511004T3 (https=)
GB (1) GB201322626D0 (https=)
PL (2) PL3089749T3 (https=)
PT (2) PT3511004T (https=)
TR (1) TR201910866T4 (https=)
WO (1) WO2015091970A1 (https=)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
US10265379B2 (en) * 2015-09-16 2019-04-23 Annabelle Rodriguez Oquendo Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for cardiovascular disease and other chronic inflammatory diseases
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
US11045547B2 (en) 2015-12-16 2021-06-29 Merck Sharp & Dohme Corp. Anti-LAG3 antibodies and antigen-binding fragments
CN108204958A (zh) * 2016-12-19 2018-06-26 伊缪泰普有限公司 结合测定
EA201991673A1 (ru) 2017-02-10 2020-01-17 Регенерон Фармасьютикалз, Инк. Меченные радиоактивным изотопом антитела к lag3 для иммуно-пэт-визуализации
US11667711B2 (en) 2020-05-27 2023-06-06 Agilent Technologies, Inc. Anti-human LAG-3 antibodies and their use in immunohistochemistry (IHC)
IL298507A (en) * 2020-05-28 2023-01-01 Immutep Sas Treatment of cancer

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JP2017503014A (ja) 2017-01-26
KR20220054915A (ko) 2022-05-03
AU2014368420A1 (en) 2016-07-07
JP6691054B2 (ja) 2020-05-20
WO2015091970A1 (en) 2015-06-25
KR102441425B1 (ko) 2022-09-08
ES2986949T3 (es) 2024-11-13
PL3089749T3 (pl) 2019-11-29
US10736940B2 (en) 2020-08-11
EP3511004A1 (en) 2019-07-17
CN105916504A (zh) 2016-08-31
KR102593917B1 (ko) 2023-10-26
DK3089749T3 (da) 2019-08-26
JP7160345B2 (ja) 2022-10-25
US20250127856A1 (en) 2025-04-24
US20160310570A1 (en) 2016-10-27
KR20220108215A (ko) 2022-08-02
DK3511004T3 (da) 2024-09-23
EP3089749B1 (en) 2019-05-22
CN112957452A (zh) 2021-06-15
KR20160093076A (ko) 2016-08-05
US20200323957A1 (en) 2020-10-15
TR201910866T4 (tr) 2019-08-21
AU2014368420B2 (en) 2019-03-07
EP4414035A2 (en) 2024-08-14
GB201322626D0 (en) 2014-02-05
US12214012B2 (en) 2025-02-04
PT3089749T (pt) 2019-09-06
ES2730976T3 (es) 2019-11-13
JP2019203035A (ja) 2019-11-28
EP4414035A3 (en) 2024-08-21
PT3511004T (pt) 2024-09-03
PL3511004T3 (pl) 2024-11-12
FI3511004T3 (fi) 2024-09-25
EP3511004B1 (en) 2024-07-03
EP3089749A1 (en) 2016-11-09

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