CN105902444A - Whitening traditional Chinese medicine composition containing terminalia bellerica fruit and used for cosmetics - Google Patents
Whitening traditional Chinese medicine composition containing terminalia bellerica fruit and used for cosmetics Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a whitening traditional Chinese medicine composition containing terminalia bellerica fruit and used for cosmetics. The composition is prepared from, by weight, 10-18 parts of morus australis, 20-30 parts of terminalia bellerica fruit, 10-15 parts of red-knees herb, 6-10 parts of semen raphani, 0.2-0.5 part of alpinia coriandriodora and 6-9 parts of gingkoes. By optimizing compatibility of the raw materials, raw material medicines of the composition have a synergistic interaction effect, the whitening effect of the composition is improved, the medicine effect is mild, and the composition is formed by combining pure natural plant extracts and is small in side effect, wide in adaptability and low in cost.
Description
Technical field
The present invention relates to cosmetic field, particularly to a kind of containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo.
Background technology
Melanin is present in a kind of protein of everyone skin base layer; ultraviolet irradiation can make melanin produce change; generate a kind of material protecting skin; moving layer by layer via cellular metabolism again; arrive skin epidermal area, thus define the skin problems such as seen mottle, the colour of skin be irregular, dark yellow.Female face pigmentation, tarnish, dark yellow etc. be the most commonly seen skin of face problem of young and middle-aged women especially this age working woman, affect emotion and the life of young and middle-aged women.
The Effect raw material that the skin-lightening cosmetic of commercial type is added at present mainly includes one or more in the raw materials such as arbutin, kojic acid, ascorbic acid, cell growth factor, skin-lightening cosmetic containing above-mentioned raw materials also causes certain injury while having whitening effect to skin, and makes product easily produce the phenomenon of the spoiled instability of variable color.Along with development, growth in the living standard and the raising to skin health consciousness of science and technology, people are more and more higher to the attention rate of cosmetics, and Chinese medicine skin-lightening cosmetic natural, green, safe and effective particularly receives publicity.Chinese medicine skin-lightening cosmetic is little with its toxic and side effects, and the occupancy volume of the market share expands year by year, but is usually present the problems such as curative effect is rapid not, effective ingredient is inconspicuous.
Summary of the invention
It is an object of the invention to overcome that the whitening effect in the presence of existing whitening Chinese medicament compositions technology is poor, whitening takes effect slow deficiency, it is provided that a kind of containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo.The said composition compatibility by optimizing materials, makes to produce between raw medicinal material synergistic function, adds the whitening effect of compositions and the speed that takes effect, and drug effect is gentle；Said composition is combined by pure natural plant extract, and side effect is little, and wide adaptability is with low cost.
In order to realize foregoing invention purpose, the invention provides a kind of containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, said composition is to be prepared from by the raw material of following weight: chicken Mulberry 10-18 part, adjoin Li Le fruit 20-30 part, Herba polygoni hydropiperis 10-15 part, Semen Raphani 6-10 part, Alpinia coriandriodora D. Fang. 0.2-0.5 part, Semen Ginkgo 6-9 part.
Above-mentioned a kind of containing adjoining the whitening Chinese medicament compositions for cosmetics of Li Leguo, wherein said chicken Mulberry, nature and flavor are sweet, pungent, cold；Return liver, spleen channel；There is clearing away heat and expelling pathogen in the exterior, the liver and the kidney tonifying, effect that blood promotes the production of body fluid；It is mainly used in treating anemopyretic cold, headache, conjunctival congestion, cough due to lung-heat.
Wherein said adjoins Li Leguo, and nature and flavor are bitter, pungent, warm；GUIXIN, lung meridian；There is resolving toxin and disinhibiting the throat；Cough-relieving dysentery relieving；Effect of nourishing blood and hemoslasis；It is mainly used in laryngopharynx swelling and pain；Cough；Dysentery；Bleeding hemorrhoids；Metrorrhagia；Body is empty after being ill.
Wherein said Herba polygoni hydropiperis, acrid in the mouth, warm in nature；Return stomach, large intestine channel；There is expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, effect of killing parasites for relieving itching；It is mainly used in treating for dysentery, gastroenteritis, diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage；Outer for venom, skin eczema.
Wherein said Semen Raphani, nature and flavor are pungent, sweet, flat；Return lung, spleen, stomach warp；There is the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm, it is mainly used in Therapeutic diet and stagnates, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Wherein said Alpinia coriandriodora D. Fang., warm in nature, acrid in the mouth；Return spleen, stomach, Liver Channel；There is regulating QI to relieve pain, damp eliminating, detumescence, effect of promoting blood circulation to remove obstruction in the collateral；It is mainly used in treating dyspepsia, suffers from abdominal pain, vomit, eructation, chronic diarrhea.
Wherein said Semen Ginkgo, property is flat, and sweet in the mouth is pained；Return lung, kidney channel；There is strengthening the spleen gas, fall expectorant, effect of detoxicating；Be mainly used in treating skin ulcer scabies cellulitis tumor, acute mastitis fester, tooth worm dental caries, infantile diarrhea, leucorrhea with red and white discharge, chronic stranguria with turbid discharge, the seminal emission enuresis.
Above-mentioned a kind of containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, it is preferred that said composition is to be prepared from by the raw material of following weight: chicken Mulberry 12-15 part, adjoin Li Le fruit 22-25 part, Herba polygoni hydropiperis 12-15 part, Semen Raphani 8-10 part, Alpinia coriandriodora D. Fang. 0.2-0.4 part, Semen Ginkgo 7-9 part；It is further preferred that said composition is to be prepared from by the raw material of following weight: 15 parts of chicken Mulberry, adjoin Li Le fruit 25 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Alpinia coriandriodora D. Fang. 0.3 part, Semen Ginkgo 8 parts.Preferably can make the synergistic function maximum of compositions by above-mentioned, whitening effect reaches optimal, and side effect is minimum.
Above-mentioned a kind of containing adjoining the whitening Chinese medicament compositions for cosmetics of Li Leguo, in addition to above-mentioned necessary raw material, also can add auxiliary material, such as, wetting agent, surfactant, ultraviolet ray-resistant material, alcohols, water etc. according to actual needs.
Above-mentioned a kind of containing adjoining the whitening Chinese medicament compositions for cosmetics of Li Leguo, cosmetics can be made with conventional base material by arbitrary proportion, State of cosmetics can be the one in solution, suspension, emulsion, paste, quintessence oil, spray.
Theory of Chinese medical science thinks liver storing blood, main catharsis, can regulating blood flow amount and adjust smooth whole body mechanism of qi, make QI and blood gentle.If mechanism of qi is uncomfortable, hematogenous blockage, the blood stasis of blood is stagnant in face then greenish complexion, or chloasma occurs.Internal organs disorder of QI and blood, skin of face lacks blood and nourishes, then lusterless complexion is intensely dark.So whitening skin lightening be conditioning viscera, QI and blood regulating at all.
Above-mentioned a kind of containing adjoining the whitening Chinese medicament compositions for cosmetics of Li Leguo, said composition is made up of the natural material of multiple gentleness.In the present invention, in conjunction with the traditional Chinese medical science " conditioning viscera, QI and blood regulating " scheduling theory, to adjoin Li Leguo as monarch drug, take effect of its nourishing blood and hemoslasis, QI and blood regulating, play the basic effect dispelling source of disease.With chicken Mulberry and Herba polygoni hydropiperis as ministerial drug, take chicken Mulberry clearing away heat and expelling pathogen in the exterior, the liver and the kidney tonifying, effect that blood promotes the production of body fluid；Take Herba polygoni hydropiperis expelling wind and removing dampness, effect of eliminating stasis to stop pain, conditioning viscera, strengthen the effectiveness of monarch drug.With Semen Raphani and Semen Ginkgo as adjuvant drug, take effect of Semen Raphani heat clearing away sending down the abnormal ascending QI；Taking Semen Ginkgo strengthening the spleen gas, effect of heat-clearing and toxic substances removing, both play the disease of holding concurrently dispelling source of disease, assist monarch, ministerial drug to play the effect of effect.With Alpinia coriandriodora D. Fang. for making medicine, take Alpinia coriandriodora D. Fang. and regulate the flow of vital energy damp eliminating, effect of promoting blood circulation to remove obstruction in the collateral.The most all medicines share, and play effect of conditioning viscera, QI and blood regulating altogether, reach the effect for the treatment of both the principal and secondary aspects of a disease simultaneously, and this Chinese medicine composition whitening effect is good, and speed is fast, and drug effect is gentle, has no side effect, and are suitable for all kinds of skin quality.
Further, the invention provides a kind of preparation method containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, its concrete preparation process is as follows:
1, by chicken Mulberry, adjoin Li Leguo, Herba polygoni hydropiperis, Semen Raphani, Semen Ginkgo be separately dried after pulverize, extract and concentrate, obtain chicken Mulberry extracting solution, adjoin Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained, really extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract carry out maturation process respectively to adjoin Li Le, carry out after cooling filtering, purifying to obtain each raw material essence, by each raw material essence mix homogeneously, add Alpinia coriandriodora D. Fang., after dissolving, again carry out filtering, purifying, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo.
Above-mentioned a kind of preparation method containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, wherein to chicken Mulberry in step 1, adjoin Li Leguo, Herba polygoni hydropiperis, Semen Raphani, the extraction of Semen Ginkgo, method for concentration are conventional plant extract, method for concentration, can be separated by the effective medical active composition in plant, and increase activity component concentration, improve whitening effect.
Above-mentioned a kind of preparation method containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, wherein in step 2 to chicken Mulberry extracting solution, adjoin Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract carry out maturation process respectively, i.e. carry out plant extraction liquid heating pressurized treatments, destroy the easy allergin in extracting solution, reduce side effect, improve the adaptability to different skin quality, and active ingredient breaks down bigger for molecular weight is become the active component of molecular weight, improve the seepage velocity to skin.
Wherein, in described curing process, the cooking conditions to each raw material is different, can be under the reactive conditions farthest ensureing whitening effect active substance, destroy the easy allergin in extracting solution, reduce side effect, and active ingredient breaks down bigger for molecular weight is become the active component of molecular weight, improve the seepage velocity to skin, its temperature, pressure and time specifically chosen as follows:
Above-mentioned a kind of preparation method containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, by to the ripening at different conditions of different material extracting solution, easy allergin in raw material extracting solution is inactivated or decomposes, and retain effective medicinal active ingredient of energy Synergistic, and active ingredient breaks down bigger for molecular weight is become the active component of molecular weight, thus not only reduce the allergy probability of Chinese medicine composition, improve adaptability, can also improve skin-permeation rate, whitening effect is more preferable, faster.
Compared with prior art, beneficial effects of the present invention:
1, the present composition passes through the rational compatibility of each raw material, makes different effective active compositions produce synergistic function, excites the property of medicine of effective active matter greatly, and whitening effect is good, faster.
2, the present composition selects multiple gentle raw material, and formulated by optimal compatibility, drug effect is gentle, has no side effect.
3, Large molecule active substance decomposition is become small-molecule active substance by curing process by the present composition, more preferable to the permeability of skin, improves whitening speed.
4, the easy allergin in raw material extracting solution is processed by the present composition by curing process, reduces easy anaphylaxis and side reaction, improves the adaptability of compositions.
Accompanying drawing explanation
Fig. 1 is that the Chinese medicine composition of the embodiment of the present invention 1 is to tyrosinase inhibition test result figure.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example, and all technology realized based on present invention belong to the scope of the present invention.
Embodiment 1
1, by 15 parts of chicken Mulberry, adjoining Li Le fruit 25 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Semen Ginkgo 8 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, and obtains chicken Mulberry extracting solution, adjoins Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained at 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying, cool down to obtain chicken Mulberry essence；At 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying by the Li Le really extracting solution that adjoins of step 1 gained, cool down to adjoin Li Le fruit essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 73 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 2h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the ginkgo extract of step 1 gained at 58 DEG C, carry out after carrying out ripening 0.5h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Ginkgo essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence, Semen Ginkgo essence mix homogeneously, add 0.3 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
It is good that this cosmetic emulsion has whitening effect, and speed is fast, has no side effect, the advantage of suitable various skin skin quality.
Embodiment 2
1, by 18 parts of chicken Mulberry, adjoining Li Le fruit 30 parts, Herba polygoni hydropiperis 10 parts, Semen Raphani 6 parts, Semen Ginkgo 9 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, and obtains chicken Mulberry extracting solution, adjoins Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained at 75 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain chicken Mulberry essence；At 70 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying by the Li Le really extracting solution that adjoins of step 1 gained, cool down to adjoin Li Le fruit essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 75 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 65 DEG C, carry out after carrying out ripening 3h under 0.1Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the ginkgo extract of step 1 gained at 60 DEG C, carry out after carrying out ripening 0.5h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Ginkgo essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence, Semen Ginkgo essence mix homogeneously, add 0.5 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
It is good that this cosmetic emulsion has whitening effect, has no side effect, the advantage of suitable various skin skin quality.
Embodiment 3
1, by 10 parts of chicken Mulberry, Li Le fruit 20 parts, Herba polygoni hydropiperis 15 parts are adjoined, Semen Raphani 10 parts, Semen Ginkgo 6 parts is pulverized after being separately dried, and extracts with ethanol solution and concentrates, and obtains chicken Mulberry extracting solution, adjoins Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying, cool down to obtain chicken Mulberry essence；At 75 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying by the Li Le really extracting solution that adjoins of step 1 gained, cool down to adjoin Li Le fruit essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 65 DEG C, carry out after carrying out ripening 2h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the ginkgo extract of step 1 gained at 55 DEG C, carry out after carrying out ripening 1h under 0.1Mpa pressure filtering, purifying, cool down to obtain Semen Ginkgo essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence, Semen Ginkgo essence mix homogeneously, add 0.2 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
It is good that this cosmetic emulsion has whitening effect, has no side effect, the advantage of suitable various skin skin quality.
Comparative example 1
1, by 15 parts of chicken Mulberry, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Semen Ginkgo 8 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, obtaining chicken Mulberry extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained at 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying, cool down to obtain chicken Mulberry essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 73 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 2h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the ginkgo extract of step 1 gained at 58 DEG C, carry out after carrying out ripening 0.5h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Ginkgo essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence, Semen Ginkgo essence mix homogeneously, add 0.3 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, the whitening Chinese medicament compositions for cosmetics obtained；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
Comparative example 2
1, will adjoin Li Le fruit 25 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Semen Ginkgo 8 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, and must adjoin Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, at 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying by the Li Le really extracting solution that adjoins of step 1 gained, cool down to adjoin Li Le fruit essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 73 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 2h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the ginkgo extract of step 1 gained at 58 DEG C, carry out after carrying out ripening 0.5h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Ginkgo essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence, Semen Ginkgo essence mix homogeneously, add 0.3 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
Comparative example 3
1, by 15 parts of chicken Mulberry, adjoining Li Le fruit 25 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, and obtains chicken Mulberry extracting solution, adjoins Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution；
2, by the chicken Mulberry extracting solution of step 1 gained at 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying, cool down to obtain chicken Mulberry essence；At 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying by the Li Le really extracting solution that adjoins of step 1 gained, cool down to adjoin Li Le fruit essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 73 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 2h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence mix homogeneously, add 0.3 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
Comparative example 4
1, by 20 parts of chicken Mulberry, adjoining Li Le fruit 15 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Semen Ginkgo 8 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, and obtains chicken Mulberry extracting solution, adjoins Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained at 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying, cool down to obtain chicken Mulberry essence；At 78 DEG C, carry out after carrying out ripening 1h under 0.2Mpa pressure filtering, purifying by the Li Le really extracting solution that adjoins of step 1 gained, cool down to adjoin Li Le fruit essence；By the Herba polygoni hydropiperis extracting solution of step 1 gained at 73 DEG C, carry out after carrying out ripening 2h under 0.1Mpa pressure filtering, purifying, cool down to obtain Herba polygoni hydropiperis essence；By the Semen Raphani extracting solution of step 1 gained at 70 DEG C, carry out after carrying out ripening 2h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Raphani essence；By the ginkgo extract of step 1 gained at 58 DEG C, carry out after carrying out ripening 0.5h under 0.2Mpa pressure filtering, purifying, cool down to obtain Semen Ginkgo essence；By the chicken Mulberry essence of gained, adjoin Li Le fruit essence, Herba polygoni hydropiperis essence, Semen Raphani essence, Semen Ginkgo essence mix homogeneously, add 0.3 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
Comparative example 5
1, by 15 parts of chicken Mulberry, adjoining Li Le fruit 25 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Semen Ginkgo 8 parts is pulverized after being separately dried, extracts with ethanol solution and concentrate, and obtains chicken Mulberry extracting solution, adjoins Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
2, by the chicken Mulberry extracting solution of step 1 gained, adjoin Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, Alpinia coriandriodora D. Fang. extracting solution, ginkgo extract mix homogeneously, add 0.3 part of Alpinia coriandriodora D. Fang., after dissolving, again purify, obtain mixing essence；
3, mixing essence step 2 obtained carries out homogenizing, obtains containing the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo；
4, take whitening Chinese medicament compositions that percentage by weight is 10% respectively, the glycerol of 15%, the sorbitol olein of 10%, the purified water of 65% make skin-lightening cosmetic emulsion.
Test example 1 suppresses tyrosinase activity to test
(1) material
1. solution preparation
(1) PBS solution (pH=6.8,0.1mol/L): 1. 17.91g disodium hydrogen phosphate is dissolved in deionized water, is settled to 500ml with deionized water.2. 7.8g sodium dihydrogen phosphate dihydrate is dissolved in deionized water, is settled to 500ml with deionized water.Take 92.6ml the most respectively and be 1. 2. configured to the phosphate buffer solution of 200ml pH=6.8 with 107.4ml.
(2) TYR solution: 0.05g is dissolved in the HCl of 35ml0.1mol/L, is settled to 100mL with PBS (0.1mol/L) buffer of pH6.8.
(3) tryrosinase: enzyme is lived as 100U/ml.
2. sample preparation
The traditional Chinese medicine composition extract liquid of embodiment 1 deionized water is diluted, is made into the sample solution that concentration is 0.05%, 0.1%, 0.2%, 0.4%, 0.8%, carry out testing below.
(2) test method
1. it is loaded according to table 1, is not added with tryrosinase.
Table 1 tyrosinase inhibition test preparation table
2. solution is placed in constant temperature 10min in 37 DEG C of water-baths.
3. add tryrosinase, solution is placed in 37 DEG C of water-baths after constant temperature 10min, under 475nm, measures its absorbance, and compare with arbutin.
Inhibitory activity against tyrosinase calculates according to formula (1):
Inhibitory activity against tyrosinase=(Blank absorbance values-sample absorbance value)/Blank absorbance values × 100 (1)
(3) experimental result
Experimental result is shown in accompanying drawing 1.Embodiment 1 Chinese medicine composition extract, just shows tyrosinase inhibitory activity in concentration 0.05%, is 44% to inhibitory activity against tyrosinase；When concentration reaches 0.2%, inhibitory activity against tyrosinase is reached more than 90%.
Test example 2
The skin-lightening cosmetic that above-described embodiment 1-3 and comparative example 1-5 obtain is tried out, randomly choose 50 and have that the colour of skin is uneven, the volunteer of dark yellow phenomenon, it is divided into 10 groups, wherein 1-8 uses the cosmetics that embodiment and comparative example prepare respectively, select the skin-lightening cosmetic that commercial type is best for 9th group, its whitening effect is detected and evaluates, wherein determines using effect by following criterion of therapeutical effect, record as follows:
Recovery from illness: patient skin colour of skin phenomenon irregular, dark yellow is wholly absent.
Effective: the patient skin colour of skin is irregular, dark yellow phenomenon has been alleviated.
Invalid: before and after patient's use, symptom is without improving.
From above proof test data, 1-3 group (embodiment 1-3) have employed the whitening Chinese medicament compositions that present composition raw material composition prepares with formula, has synergistic function, and whitening effect is notable, and speed is fast, and continuous and effective；4th group (comparative example 1) does not adds monarch drug and adjoins Li Leguo, and compositions compatibility changes completely, and drug effect changes, and whitening effect is very poor；5th group (comparative example 2) does not adds ministerial drug chicken Mulberry, and compositions compatibility changes, and loses synergistic function between medical material, and whitening effect is deteriorated；6th group (comparative example 3) does not adds adjuvant drug Semen Ginkgo, and compositions compatibility changes, and loses synergistic function between medical material, and whitening effect is deteriorated；7th group (comparative example 4) does not use the raw material number of the present composition, and compatibility changes, and chicken Mulberry becomes monarch drug, adjoin Li Leguo and become ministerial drug, the overall property of medicine of compositions prepared changes, and also loses synergistic function between medical material, and whitening effect is deteriorated；The method that 8th group (comparative example 5) does not use the present invention to prepare compositions, has preferable whitening effect equally, but the onset of drug effect slows, and the whitening time is elongated；9th group is situation after existing skin-lightening cosmetic uses, and its whitening effect is general, and after speed is general, and time-out uses, the colour of skin occurs dark yellow phenomenon the most again.
Claims (9)
1. one kind contains the whitening Chinese medicament compositions for cosmetics adjoining Li Leguo, it is characterised in that described compositions is by following heavy
The raw material of amount part proportioning is prepared from: chicken Mulberry 10-18 part, adjoins Li Le fruit 20-30 part, Herba polygoni hydropiperis 10-15 part, Semen Raphani 6-10
Part, Alpinia coriandriodora D. Fang. 0.2-0.5 part, Semen Ginkgo 6-9 part.
Chinese medicine composition the most according to claim 1, it is characterised in that described compositions is by the raw material system of following weight
Standby: chicken Mulberry 12-15 part, adjoin Li Le fruit 22-25 part, Herba polygoni hydropiperis 12-15 part, Semen Raphani 8-10 part, Alpinia coriandriodora D. Fang. 0.2-0.4
Part, Semen Ginkgo 7-9 part.
Chinese medicine composition the most according to claim 2, it is characterised in that described compositions is by the raw material system of following weight
Standby: 15 parts of chicken Mulberry, adjoin Li Le fruit 25 parts, Herba polygoni hydropiperis 12 parts, Semen Raphani 9 parts, Alpinia coriandriodora D. Fang. 0.3 part, Semen Ginkgo 8 parts.
4. according to Chinese medicine composition described in any one of claim 1-3, it is characterised in that the preparation method of described Chinese medicine composition, its
Concrete preparation process is as follows:
(1), by chicken Mulberry, adjoin Li Leguo, Herba polygoni hydropiperis, Semen Raphani, Semen Ginkgo be separately dried after pulverize, extract and concentrate,
Chicken Mulberry extracting solution, adjoin Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, ginkgo extract；
(2), by the chicken Mulberry extracting solution of step 1 gained, Li Le fruit extracting solution, Herba polygoni hydropiperis extracting solution, Semen Raphani extracting solution, silver are adjoined
Fructus Pruni extracting solution carries out maturation process respectively, carries out filtering, purifying to obtain each raw material essence after cooling, is mixed by each raw material essence
Uniformly, add Alpinia coriandriodora D. Fang., after dissolving, again carry out filtering, purifying, obtain mixing essence；
(3) the mixing essence, by step 2 obtained carries out homogenizing, obtains containing in the whitening for cosmetics adjoining Li Leguo
Drug composition.
Chinese medicine composition the most according to claim 4, it is characterised in that in the preparation method step 2 of described compositions, Mulberry carries chicken
Take the curing temperature of liquid be 75-80 DEG C, pressure be 0.1-0.2Mpa, the time be 1-2h.
Chinese medicine composition the most according to claim 4, it is characterised in that in the preparation method step 2 of described compositions, adjoin Li Le
Really the curing temperature of extracting solution be 75-80 DEG C, pressure be 0.1-0.2Mpa, the time be 1-2h.
Chinese medicine composition the most according to claim 4, it is characterised in that in the preparation method step 2 of described compositions, Herba polygoni hydropiperis carries
Take the curing temperature of thing be 70-75 DEG C, pressure be 0.1-0.2Mpa, the time be 1-2h.
Chinese medicine composition the most according to claim 4, it is characterised in that in the preparation method step 2 of described compositions, Semen Raphani
The curing temperature of extracting solution is 65-70 DEG C, pressure is 0.1-0.2Mpa, the time is 2-3h.
Chinese medicine composition the most according to claim 4, it is characterised in that in the preparation method step 2 of described compositions, Semen Ginkgo carries
Take the curing temperature of liquid be 55-60 DEG C, pressure be 0.1-0.2Mpa, the time be 0.5-1h.
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