CN105899519B - 金属络合物及治疗方法 - Google Patents
金属络合物及治疗方法 Download PDFInfo
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- CN105899519B CN105899519B CN201480072886.9A CN201480072886A CN105899519B CN 105899519 B CN105899519 B CN 105899519B CN 201480072886 A CN201480072886 A CN 201480072886A CN 105899519 B CN105899519 B CN 105899519B
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- A61K33/34—Copper; Compounds thereof
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- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902682P | 2013-11-11 | 2013-11-11 | |
| US61/902682 | 2013-11-11 | ||
| US201461932348P | 2014-01-28 | 2014-01-28 | |
| US61/932348 | 2014-01-28 | ||
| PCT/US2014/064879 WO2015070177A2 (en) | 2013-11-11 | 2014-11-10 | Metal complexes and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105899519A CN105899519A (zh) | 2016-08-24 |
| CN105899519B true CN105899519B (zh) | 2021-11-09 |
Family
ID=51982795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480072886.9A Expired - Fee Related CN105899519B (zh) | 2013-11-11 | 2014-11-10 | 金属络合物及治疗方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11266686B2 (enExample) |
| EP (1) | EP3068762B1 (enExample) |
| JP (1) | JP6619348B2 (enExample) |
| CN (1) | CN105899519B (enExample) |
| AU (1) | AU2014346476B2 (enExample) |
| CA (1) | CA2930290C (enExample) |
| ES (1) | ES2778038T3 (enExample) |
| IL (1) | IL245593B (enExample) |
| WO (1) | WO2015070177A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2813223B8 (en) | 2006-11-20 | 2018-03-07 | The University of Melbourne | Metal delivery agents and therapeutic uses of the same |
| US10413554B2 (en) | 2006-11-20 | 2019-09-17 | The University Of Melbourne | Metal delivery agents and therapeutic uses of the same |
| US11142835B2 (en) | 2016-06-10 | 2021-10-12 | University Of Louisville Research Foundation, Inc. | Compounds, their preparation, related compositions, catalysts, electrochemical cells, fuel cells, and uses thereof |
| US11208379B2 (en) | 2017-05-04 | 2021-12-28 | University Of Louisville Research Foundation, Inc. | Compounds, compositions, methods for treating diseases, and methods for preparing compounds |
| EP3676271A1 (en) | 2017-09-01 | 2020-07-08 | Oregon State University | Therapeutic metal complexes and ligands and methods of making and using same |
| CN108129522A (zh) * | 2018-01-05 | 2018-06-08 | 广西师范学院 | 酞菁连芳基钌化合物及其用途和制备方法 |
| WO2020147029A1 (en) * | 2019-01-16 | 2020-07-23 | Shenzhen Vast Conduct Science Research Co., Ltd. | Copper nanoclusters, thymine-modified hyaluronic acid and poly (copper nanoclusters), method for preparing the same, and application thereof |
| CA3152807A1 (en) * | 2019-07-25 | 2021-01-28 | Als Therapy Development Institute | Cuptsm for the treatment of neurodegenerative disorders |
| WO2021042048A1 (en) * | 2019-08-30 | 2021-03-04 | Research Institute At Nationwide Children's Hospital | Copper-atsm for treating neurodegenerative disorders associated with mitochondrial dysfunction |
| US20220289587A1 (en) * | 2019-09-03 | 2022-09-15 | Procypra Therapeutics, Llc | A novel polymorph and uses thereof |
| CN111747845B (zh) * | 2020-06-24 | 2022-11-01 | 中南民族大学 | 一种可见光催化选择性氧化葡萄糖的方法 |
| BR112023003512A2 (pt) * | 2020-08-26 | 2023-05-09 | Als Therapy Development Inst | Complexos de cobre para tratamento de distúrbios neurodegenerativos |
| CN112999243B (zh) * | 2021-03-05 | 2022-07-29 | 北京工业大学 | 金络合物在制备预防和/或治疗多发性硬化症的药物中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078163A2 (en) * | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2008061306A1 (en) * | 2006-11-20 | 2008-05-29 | The University Of Melbourne | Metal delivery agents and therapeutic uses of the same |
| CN102317257A (zh) * | 2008-12-12 | 2012-01-11 | 墨尔本大学 | 制备不对称双(缩氨基硫脲)的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5716895A (en) * | 1980-07-05 | 1982-01-28 | Otsuka Chem Co Ltd | Platinum 2 complex and antitumor agent containing the same as active principle |
| US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
| JPH10101566A (ja) * | 1996-09-27 | 1998-04-21 | Kagaku Gijutsu Shinko Jigyodan | 網膜保護剤 |
| WO2001055698A1 (en) | 2000-01-28 | 2001-08-02 | Pion, Inc. | MEASUREMENT OF SOLUBILITY-pH PROFILES |
| AU2013249307B2 (en) | 2012-04-17 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for non-invasive imaging |
-
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- 2014-11-10 ES ES14803023T patent/ES2778038T3/es active Active
- 2014-11-10 CN CN201480072886.9A patent/CN105899519B/zh not_active Expired - Fee Related
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078163A2 (en) * | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| WO2008061306A1 (en) * | 2006-11-20 | 2008-05-29 | The University Of Melbourne | Metal delivery agents and therapeutic uses of the same |
| CN102317257A (zh) * | 2008-12-12 | 2012-01-11 | 墨尔本大学 | 制备不对称双(缩氨基硫脲)的方法 |
Non-Patent Citations (5)
| Title |
|---|
| "Functionalized Bis(thiosemicarbazonato) Complexes of Zinc and Copper: Synthetic Platforms Toward Site-Specific Radiopharmaceuticals";Jason P. Holland et al.;《Inorg. Chem.》;20061222;第46卷(第2期);第465-485页 * |
| "Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents";Paul McQuade et al.;《Nuclear Medicine and Biology》;20051231;第32卷;第147-156页 * |
| "Structural trends in copper(II) bis(thiosemicarbazone) radiopharmaceuticals";Philip J. Blower et al.;《Dalton Trans.》;20030930(第23期);第4416-4425页 * |
| Jason P. Holland et al.."Functionalized Bis(thiosemicarbazonato) Complexes of Zinc and Copper: Synthetic Platforms Toward Site-Specific Radiopharmaceuticals".《Inorg. Chem.》.2006,第46卷(第2期),第465-485页. * |
| Philip J. Blower et al.."Structural trends in copper(II) bis(thiosemicarbazone) radiopharmaceuticals".《Dalton Trans.》.2003,(第23期),第4416-4425页. * |
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| IL245593B (en) | 2020-01-30 |
| AU2014346476B2 (en) | 2019-01-24 |
| CN105899519A (zh) | 2016-08-24 |
| US20160271175A1 (en) | 2016-09-22 |
| CA2930290C (en) | 2023-02-28 |
| CA2930290A1 (en) | 2015-05-14 |
| JP2016540828A (ja) | 2016-12-28 |
| AU2014346476A1 (en) | 2016-06-23 |
| WO2015070177A3 (en) | 2015-10-08 |
| EP3068762A2 (en) | 2016-09-21 |
| ES2778038T3 (es) | 2020-08-07 |
| WO2015070177A2 (en) | 2015-05-14 |
| IL245593A0 (en) | 2016-06-30 |
| US11266686B2 (en) | 2022-03-08 |
| JP6619348B2 (ja) | 2019-12-11 |
| EP3068762B1 (en) | 2019-12-25 |
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