CN105891428A - Full-automatic monogastric animal bionic digestive system - Google Patents
Full-automatic monogastric animal bionic digestive system Download PDFInfo
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- CN105891428A CN105891428A CN201610426936.XA CN201610426936A CN105891428A CN 105891428 A CN105891428 A CN 105891428A CN 201610426936 A CN201610426936 A CN 201610426936A CN 105891428 A CN105891428 A CN 105891428A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
The invention provides a full-automatic monogastric animal bionic digestive system. According to a full-automatic monogastric animal bionic digestive instrument, a digestive reaction chamber is arranged on the upper left portion of a case, and a constant-temperature air bath shaker device is arranged in the digestive reaction chamber; an automatic enzyme adding device is fixedly installed in the case, and the automatic enzyme adding device is connected with a bionic digestive device through an infusion tube; a buffer solution circulating device and a washing device are arranged on the lower portion of the case and connected with the bionic digestive device through infusion tubes; a control circuit is arranged in the case and connected with the constant-temperature air bath shake device, the automatic enzyme adding device, the buffer solution circulating device and the washing device through wires; the control circuit is connected with an industrial personal computer installed in the case, and the industrial personal computer is connected with a displayer installed on the upper right portion of the case; the bionic digestive device is vertically installed above the constant-temperature air bath shaker. The full-automatic monogastric animal bionic digestive instrument is simple in structure and convenient to use, leakage of bionic digestive reaction liquid can be avoided, the accuracy and repeatability of simulative digestion are good, and errors are small.
Description
Technical field
The present invention relates to a kind of animal Bionic digestion device, especially relate to a kind of digestive appartus of simulating and vertically lay the full-automatic Bionic digestive system for monogastric animals that Bionic digestion is indoor.
Background technology
In modern farming, the objective nutrient biological value accurately evaluating feedstuff determines that Animal nutrition requirement and optimizes the primary decision-making basis of feed formula.In China, feedstuff is of a great variety, renewal speed faster in the case of, if at least needing many decades with the biological value of the whole general survey of animal experiment method, prediction feed nutrient, and result is only capable of obtaining the most limited static parameter.Therefore, in order to break through the technical bottleneck that restriction China feed nutrient biological value parameter updates, designing a kind of science, accurately and rapidly feed nutrient biological value testing tool is to be badly in need of, and it can be that modern farming provides technical support.
CN104034912A
Disclosing a kind of full-automatic monogastric animal bionic digestion instrument, including casing, constant temperature air bath shaking table device, Bionic digestion device, automatic enzyme-added device, buffer circulating device, clean device, control circuit, the upper left side of described casing is provided with digestion reaction room；It is indoor that described constant temperature air bath shaking table device and Bionic digestion device are located at described digestion reaction；Described automatic enzyme-added device fixedly mounts on the housing, and automatic enzyme-added device is connected by tube for transfusion with described Bionic digestion device；Described buffer circulating device and cleaning device are located at the lower section of described casing, and buffer circulating device, cleaning device are connected with described Bionic digestion device by tube for transfusion respectively；Described control circuit is located at below casing, and is connected with described constant temperature air bath shaking table device, automatic enzyme-added device, buffer circulating device, cleaning device with crossing wire.The simulation digestive appartus of this full-automatic monogastric animal bionic digestion instrument is that horizontal (the most laterally disposed) is in constant temperature air bath shaking table device, simulation digestion process, easily because of in Dialysis tubing feedstuff in digestion process aerogenesis and cause the rubber stopper of Bionic digestion tube end outwards to come off, the problem such as reactant liquor leakage, secondly, during Bionic digestion, treating that sample digestion easily sticks causes bag filter blocked on bag filter, and then affects the digestion effect of Feed Sample.
Summary of the invention
The technical problem to be solved in the present invention is: overcome the deficiencies in the prior art, a kind of simple in construction is provided, easy to operate, Bionic digestion reactant liquor can be avoided to reveal, and the bag filter in simulation digestive appartus is by the full-automatic Bionic digestive system for monogastric animals of the phenomenons such as cellulose degraded；Under in vitro conditions, this system can realistic simulation feedstuff digested in animal gastrointestinal tract, absorb process.
The technical solution adopted for the present invention to solve the technical problems is: a kind of full-automatic monogastric animal bionic digestion instrument, including casing, constant temperature air bath shaking table, Bionic digestion device, automatic enzyme-added device, buffer circulating device, clean device, control circuit, the upper left side of described casing is provided with digestion reaction room, and it is indoor that described constant temperature air bath shaking table device is located at digestion reaction；Described automatic enzyme-added device is fixedly mounted in casing, and automatic enzyme-added device is connected by tube for transfusion with Bionic digestion device；Described buffer circulating device and cleaning device are located at the lower section of casing, and buffer circulating device, cleaning device are connected with Bionic digestion device by tube for transfusion respectively；Described control circuit is located in casing, and be connected with constant temperature air bath shaking table device, automatic enzyme-added device, buffer circulating device, cleaning device by wire, described control circuit is connected with the industrial computer being arranged in casing, and described industrial computer is connected with being arranged on the top-right display of casing；Described Bionic digestion device is vertically installed at above constant temperature air bath shaking table, i.e. the central axis of Bionic digestion device is vertical with constant temperature air bath shaking table.
Further, described Bionic digestion device includes fixed support, vertical simulation digestive appartus, glass tubing fixation clamp, stirring rod, motor and actuating device；Described vertical simulation digestive appartus is simulated digestive tube by the dialysis of several series connection and/or double glazing simulation digestive tube forms；Described vertical simulation digestive appartus vertically clamps and is arranged in described glass tubing fixation clamp, and described stirring rod is arranged in vertical simulation digestive tube, and its top removably connects with actuating device；Described actuating device electrically connects with the motor being arranged on fixed support top；Described glass tubing fixation clamp is fixedly mounted in the middle part of fixed support.
Further, glass inner tube and enzyme-added pipe that described double glazing simulation digestive tube by vertical glass tubing, is set in hollow tube form, and described vertical glass tubing is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground, is plugged with sealing-plug in ground；Hollow tube side wall lower ends and upper end are respectively equipped with the second input pipe and the second outlet tube；Described enzyme-added pipe is through hollow tube sidewall and extends in glass inner tube, and hollow tube inner space is separated into outer cavity volume and content cavity by glass inner tube.The second input pipe on double glazing simulation digestive tube is insulation thermostatted water input port, second outlet tube is insulation thermostatted water delivery outlet, in two adjacent double glazing simulation digestive tubes, the thermostatted water input port of a forward double glazing simulation digestive tube is connected by delivery hose with the thermostatted water delivery outlet of another double glazing simulation digestive tube, and all of double glazing simulation digestive tube is sequentially connected in series by described delivery hose；The thermostatted water delivery outlet of the most forward double glazing simulation digestive tube, the thermostatted water input port of double glazing simulation digestive tube the most rearward are connected with described circulating water device by water-supply-pipe respectively.The enzyme-added pipe in described vertical glass tubing upper end is Digestive system input port or buffer input port；The Digestive system input port of each described double glazing simulation digestive tube is connected by flexible pipe with described automatic enzyme-added device, and buffer input port is connected with buffer circulating device.
Further, described actuating device includes connecting bushing and heightens drive link, and described connecting bushing is set on motor output shaft, synchronously rotates with motor；The described bottom heightening drive link is connected with stirring rod, and its top is fixed in the chute below connecting bushing by screw rod socket, and making to heighten drive link can move up and down in connecting bushing；Described drive link of heightening is provided with locking nut, for heightening the locking degree between drive link and stirring rod.
Further, described drive link of heightening includes the body of rod and jaw, one end of the described body of rod is fixing with jaw to be connected, body of rod outer wall near jaw is provided with external screw thread, external screw thread matches with the female thread of the locking nut for regulating jaw locking degree, and the one end away from jaw at least offers 2 for the fixing hole installing screw rod；It is additionally provided with groove in the middle part of the described body of rod.
Further, described fixed support is made up of base plate, lower frame plate, backboard, side plate and gripper shoe, and described base plate is fixing with lower frame plate to be connected；Described lower frame plate is by one piece of metallic plate bending and molding, and including a horizontal fixed plate and two pieces of risers erect, two risers are positioned at below horizontal fixed plate, and is connected with two ends, the left and right one of horizontal fixed plate；The lower end of riser is all bent up being converted into fixed block, and fixing hole is provided with hole, location；The first through hole for fixing vertical glass tubing fixation clamp is offered on horizontal fixed plate, described backboard, side plate are fixed on the back upper place of lower frame plate, the top of described backboard and side plate is fixing with gripper shoe to be connected, and described gripper shoe is additionally provided with motor fixing threaded hole and motor shaft perforation.
Further, described backboard, side plate and gripper shoe are provided with passage, and described backboard and/or gripper shoe are additionally provided with pipeline perforation.
Further, described base plate offers U-shaped draw-in groove and installing hole.
Further, described glass tubing fixation clamp is made up of the first clamping plate, the second clamping plate and snap close, the end face that described first clamping plate and the second clamping plate contact with each other is provided with several clamp groove for placing vertical glass tubing, is additionally provided with the cushion course that shape adapts with clamp groove in described clamp groove.Described first clamping plate are provided with the second through hole, the middle part of described first clamping plate and the second clamping plate side is provided with connection fixing hole, described snap close, by being fixed on the first clamping plate and the side of the second clamping plate through the screw connecting fixing hole, fixes the first clamping plate and the second clamping plate for buckle.
Further, described dialysis simulation digestive tube includes vertical glass tubing and Dialysis tubing, and Dialysis tubing is placed in this vertical glass tubing；Described vertical glass tubing is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground, and its side bottom and upper end are respectively equipped with the first input pipe and the first outlet tube；The two ends of Dialysis tubing are stretched out at the two of this vertical glass tubing grounds respectively and are turned up, the Dialysis tubing end being exposed to outside ground of turning up is tied up by rubber bar and is fixed on ground, ground after hollow tube upper and lower side ties up Dialysis tubing end is plugged with the silica gel plug with at least tube for transfusion and solid silicon plug respectively, offers the groove placing actuating device in the middle part of the described silica gel plug with at least tube for transfusion.The first input pipe on dialysis simulation digestive tube is buffer input port, first outlet tube is buffer delivery outlet, in two adjacent dialysis simulation digestive tubes, the buffer input port of a forward dialysis simulation digestive tube is connected by infusion tube with the buffer delivery outlet of another dialysis simulation digestive tube, and all of dialysis simulation digestive tube is sequentially connected in series by described infusion tube；The buffer delivery outlet of the most forward dialysis simulation digestive tube, the buffer input port of dialysis simulation digestive tube the most rearward are connected with described buffer circulating device by tube for transfusion respectively.The middle part of described tube for transfusion is provided with check valve, and the end of tube for transfusion is provided with snap joint, and described snap joint is described Digestive system input port；The Digestive system input port of each described dialysis simulation digestive tube is connected by flexible pipe with described automatic enzyme-added device.
Further, described actuating device includes that magnetic core, magnetic core fix seat and connecting shaft；Described magnetic core is fixed and is provided with magnetic loop cover outside seat；Described magnetic core is fixed seat by bearing with magnetic core and is connected；The bottom of described magnetic core is connected with groove matched in clearance；The upper end of described connecting shaft is set in outside magnetic core, its bottom and the hollow top clamping of stirring rod.
Further, described actuating device includes outer magnetic ring set, outer magnetic ring, isolation cover, internal magnetic ring and internal magnetic ring pitman；Described outer magnetic ring set is fixed with the output shaft of motor, upper seal bootr and is connected；Described outer magnetic ring is nested and is located in outer magnetic ring；It is provided with isolation cover between described internal magnetic ring and outer magnetic ring；Described internal magnetic ring is arranged in isolation cover；One end of described internal magnetic ring pitman snaps in internal magnetic ring, and its other end is inserted through lower seal bootr and silica gel plug, is connected with the top of stirring rod.
Further, the middle part of described digestion reaction room is provided with one piece of dividing plate, is provided with wind-tunnel in the middle of dividing plate；Described digestion reaction room is divided into first half and latter half by described dividing plate, and described first half is connected by described wind-tunnel with latter half；The left and right sides of described first half further respectively has baffle plate, and baffle plate is provided with multiple air holes；The baffle plate in the left side being positioned at first half is connected with described latter half with casing outer wall enclosed space, and the baffle plate on right side being positioned at first half is connected with described latter half with the intermediate plate enclosed space of casing；Described constant temperature air bath shaking table includes that shaking table, electric fan, electric heater, described shaking table are arranged in described first half, and described electric fan is arranged at described wind-tunnel, and described electric heater is arranged in described latter half；Described Bionic digestion device is fixedly mounted on the top of described shaking table.
Further, described shaking table includes that shaking table drives motor, major axis, short axle, fixed plate, pallet fixed plate, and shaking table drives motor, major axis and short axle to be arranged on the diverse location of fixed plate；Major axis and short axle both pass through fixed plate, and one end of major axis is provided with the first belt pulley, and the other end is connected with pallet fixed plate, and one end of short axle is connected with pallet fixed plate；Shaking table drives the fixing end of motor to be arranged in fixed plate, and round end connects the second belt pulley；Described first belt pulley and the second belt pulley are linked together by belt.
Further, described major axis and short axle are eccentric shaft；The quantity of described major axis is one, and the quantity of short axle is two；Major axis and two short axles are that the shaped formation of equilateral triangle is arranged in fixed plate, and the triangle that i.e. major axis axle center and 3, two short axle axle center line are formed is equilateral triangle；Described fixed plate is arranged in fixed plate through the first installing hole by screw being equipped with the first installing hole for installing major axis and short axle, major axis and short axle with major axis, short axle corresponding section；It is mounted on bearing on described major axis, short axle；Described fixed plate is provided with the second installing hole driving motor for installing shaking table.
Further, described automatic enzyme-added device includes cold closet, peristaltic pump, refrigeration mechanism, is provided with a heat exchanger, a test tube rack and multiple Sheng enzyme pipe in described cold closet, and described heat exchanger and test tube rack are fixedly mounted in described cold closet；Described Sheng enzyme pipe is placed on described test tube rack；Described heat exchanger is connected by refrigerant pipe with described refrigeration mechanism；The upper end of described Sheng enzyme pipe is open end, and each lower end containing enzyme pipe is connected with a defeated enzyme flexible pipe；Described defeated enzyme flexible pipe is connected through the tank wall of described cold closet by the Digestive system input port of described peristaltic pump with described simulation digestive appartus.
Further, described peristaltic pump is provided with motor, pump seat, drive end bearing bracket, rear end cap, connecting rod, roller bundle, fastener；Described motor is fixedly mounted on described pump seat, and the front end of described pump seat is fixing with the rear end of described rear end cap to be connected, and the front end of described rear end cap is connected by described connecting rod is fixing with the rear end of described drive end bearing bracket；Described roller bundle is provided with many rollers, and roller bundle is arranged between described drive end bearing bracket and rear end cap, the rear end of roller bundle and described motors, and is driven roller bundle around the central axis of roller bundle by motor；Described fastener is across above described roller bundle, and the lower end of fastener is fixing with described connecting rod to be connected, and is provided with through hole in fastener, and described defeated enzyme flexible pipe is connected through described through hole with the Digestive system input port of described simulation digestive appartus.
The beneficial effect of a kind of full-automatic Bionic digestive system for monogastric animals of the present invention:
1) Bionic digestive system for monogastric animals of the present invention and method based on the digestion of this system simulation nonruminant achieve under in vitro conditions the process that simulation feedstuff is digested in animal gastrointestinal tract, absorb, whole simulation process has been automatically controlled by computer, can unmanned, eliminate interference from human factor, reliability is high, simulation verisimilitude is high, and simulation repeatability is good.Present system simple in construction, the inventive method is easy to operate, is particularly well-suited to the quick mensuration of the monogastric animal feed nutrient biological values such as pig, chicken, duck.
2) by injecting such as stomach in Dialysis tubing, duodenum, jejunum, ileum, large intestine, Digestive system and corresponding change of the different digestive tract section such as small intestinal are passed through the buffer in vertical glass tubing, or, by injecting such as stomach to glass inner tube, duodenum, jejunum, ileum, large intestine, the Digestive system of the different digestive tract section such as small intestinal and buffer, and in vertical glass tubing, it is passed through the water of constant temperature, rotated by constant temperature air bath shaking table and under the common effect of driven by motor stirring rod stirring mixing, present invention can be implemented in conditions in vitro Imitating feedstuff digested and situation of absorption in each section of animal intestines and stomach digestive tract, such as realize nonruminant stomach, small intestinal and big intestinal digestion, the simulation of absorption process.
3) present system and method are possible not only to the digestion of the stomach to nonruminant, small intestinal and large intestine, absorption process is the most individually simulated, the digestion of the stomach of nonruminant, small intestinal and large intestine, absorption process can also be carried out continuous analog, this continuous continual analog form can be avoided residue problem occur in chyme transfer.
4) being sequentially connected in series between the input pipe of each vertical simulation digestive appartus in present system, outlet tube, this series system ensure that the electrochemical conditions in all simulation digestive appartus is consistent, thus reduces simulation error, improves simulation precision.
5) it is vertically installed at above constant temperature air bath shaking table due to the Bionic digestion device in present system, there is not liquid in the upper end of vertical simulation digestive appartus, only vertically remain and the gas of digestion reaction generation in glass tubing or glass inner tube, owing to gas is more weak to the active force of silica gel plug, and there is the gravity of effect downwards in silica gel plug/sealing-plug, therefore during using, the gas that simulation digestion produces is difficult to come off silica gel plug/sealing-plug in the ground of vertical glass tubing end, can be prevented effectively from the glass tubing of traverse in prior art causes the rubber stopper at glass tubing two ends to come off because of digestion reaction aerogenesis in simulation digestion process, the phenomenon that reactant liquor is revealed, improve the Stability and veracity of Bionic digestion；
6) tie up due to the Dialysis tubing in present system with the position rubber bar that contacts of vertical glass tubing and stopper with turned welt rubber stopper, therefore, the container containing liquid that Dialysis tubing and glass tubing respectively constitute is the most independent, separate, buffer is respectively at glass tubing with the digestion product of generation, in the container that Dialysis tubing the two is different, mass exchange between them must be carried out by the molecular sieve on Dialysis tubing, so, present system can avoid occurring directly to carry out between buffer and digestion product the phenomenon of mass exchange because Dialysis tubing is poorly sealed, ensure that accuracy and the verisimilitude of simulation animal gastrointestinal tract.And, Dialysis tubing cannot be returned after flowing into glass tubing due to digestion product via the molecular sieve on Dialysis tubing, Dialysis tubing can proceed with other digestion reactions, therefore, this independent design of Dialysis tubing and two containers of glass tubing can effectively reduce the suppression of digestion product reaction digested to Dialysis tubing, accurately distinguish out digestion material and undigested material, be conducive to the digestion process making simulation animal gastrointestinal tract more to approach virtual condition.
7) when using present system, each simulation input pipe of digestive appartus, outlet tube lay respectively at lower section, top, and such placement design not only improves the circulation of buffer, and the buffer being conducive to again digestion to remain in glass tubing after terminating can be by thorough emptying.
8) in the present invention, by controlling temperature and the flow velocity of buffer, can the most accurately control the temperature simulating in the Dialysis tubing of digestive appartus, so that the temperature variations amplitude of Bionic digestion process is maintained in 0.4 DEG C, closer to the range of variation of animal heat, simulate effective.
Accompanying drawing explanation
Fig. 1 is the stereochemical structure signal of a kind of full-automatic Bionic digestive system for monogastric animals in embodiment 1；
Fig. 2 is the rearview of a kind of full-automatic Bionic digestive system for monogastric animals in embodiment 1；
Fig. 3 is the enlarged diagram in Fig. 1 at A；
Fig. 4 is the sectional view in C-C cross section in Fig. 3；
Fig. 5 is the sectional view of double glazing simulation Dialysis tubing in Fig. 3；
Fig. 6 is the perspective view heightening drive link in Fig. 3；
Fig. 7 is support bracket fastened perspective view in Fig. 3；
Fig. 8 is the perspective view of glass tubing test tube clamp in Fig. 3；
Fig. 9 is the enlarged diagram of constant temperature air bath shaking table at B in Fig. 2；
Figure 10 is the front view of Bionic digestion device in embodiment 2；
Figure 11 is the sectional view in D-D cross section in Figure 10；
Figure 12 is the enlarged diagram in Figure 11 at E；
Figure 13 is the front view of Bionic digestion device in embodiment 3；
Figure 14 is the sectional view in F-F cross section in Figure 13；
Figure 15 is the enlarged diagram in Figure 14 at G.
Detailed description of the invention
Below in conjunction with drawings and Examples, the invention will be further described.
Embodiment
1
With reference to Fig. 1 ~ 5, a kind of full-automatic monogastric animal bionic digestion instrument of the present embodiment, including casing 2, constant temperature air bath shaking table 6, Bionic digestion device 4, automatic enzyme-added device, buffer circulating device, clean device, control circuit 5, the upper left side of described casing 2 is provided with digestion reaction room 3, and described constant temperature air bath shaking table 6 device is located in digestion reaction room 3；Described automatic enzyme-added device is fixedly mounted in casing 2, and automatic enzyme-added device is connected by tube for transfusion 58 with Bionic digestion device 4；Described buffer circulating device and cleaning device are located at the lower section of casing 2, and buffer circulating device, cleaning device are connected with Bionic digestion device 4 by tube for transfusion 58 respectively；Described control circuit 5 is located in casing 2, and be connected with constant temperature air bath shaking table 6 device, automatic enzyme-added device, buffer circulating device, cleaning device by wire, described control circuit 5 is connected with the industrial computer being arranged in casing, and described industrial computer is connected with being arranged on the top-right display of casing 21；Described Bionic digestion device 4 is vertically installed at above constant temperature air bath shaking table 6, i.e. the central axis of Bionic digestion device 4 is vertical with constant temperature air bath shaking table 6.
With reference to Fig. 3, described Bionic digestion device 4 includes fixed support, vertical simulation digestive appartus, glass tubing fixation clamp 7, stirring rod 11, motor 15 and actuating device；Described vertical simulation digestive appartus is made up of the double glazing simulation digestive tube of 2 groups, often group 5 series connection；Described vertical simulation digestive appartus vertically clamps and is arranged in described glass tubing fixation clamp 7, and described stirring rod 11 is arranged in vertical simulation digestive tube, and its top removably connects with actuating device；Described actuating device electrically connects with the motor 15 being arranged on fixed support top；Described glass tubing fixation clamp 7 is fixedly mounted in the middle part of fixed support.
With reference to Fig. 5, glass inner tube 26 and enzyme-added pipe 9 that described double glazing simulation digestive tube by vertical glass tubing 8, is set in hollow tube form, described vertical glass tubing 8 is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground, is plugged with sealing-plug 21 in ground；Hollow tube side wall lower ends and upper end are respectively equipped with the second input pipe 27 and the second outlet tube 10；Described enzyme-added pipe 9 through hollow tube sidewall and extends in glass inner tube 26, and hollow tube inner space is separated into outer cavity volume and content cavity by glass inner tube 26.
With reference to Fig. 6, described actuating device includes connecting bushing 14 and heightens drive link 13, and described connecting bushing 14 is set on motor 15 output shaft, synchronously rotates with motor 15；The described bottom heightening drive link 13 is connected with stirring rod 11, and its top is fixed by socket in the chute 23 below connecting bushing 14 by screw rod 22, and making to heighten drive link 13 can move up and down in connecting bushing 14；Described drive link 13 of heightening is provided with locking nut 12, for heightening the locking degree between drive link 13 and stirring rod 11.
Described drive link 13 of heightening includes the body of rod and jaw 25, one end of the described body of rod is fixing with jaw 25 to be connected, body of rod outer wall near jaw 25 is provided with external screw thread 28, external screw thread 28 and the female thread being used for regulating the locking nut 12 that jaw 25 locks degree match, and the one end away from jaw 25 at least offers 2 for the fixing hole 30 installing screw rod 22；Groove 29 it is additionally provided with in the middle part of the described body of rod.
With reference to Fig. 7, described fixed support is made up of base plate 20, lower frame plate 19, backboard 18, side plate 17 and gripper shoe 16, and described base plate 20 is fixing with lower frame plate 19 to be connected；Described lower frame plate 19 is by one piece of metallic plate bending and molding, and including a horizontal fixed plate and two pieces of risers erect, two risers are positioned at below horizontal fixed plate, and is connected with two ends, the left and right one of horizontal fixed plate；The lower end of riser is all bent up being converted into fixed block, and fixing hole 30 is provided with hole 37, location；The first through hole 34 for fixing vertical glass tubing 8 fixation clamp 7 is offered on horizontal fixed plate, described backboard 18, side plate 17 are fixed on the back upper place of lower frame plate 19, the top of described backboard 18 and side plate 17 is fixing with gripper shoe 16 to be connected, and described gripper shoe 16 is additionally provided with motor fixing threaded hole 32 and motor shaft perforation 31.
Described backboard 18, side plate 17 and gripper shoe 16 are provided with passage 24, and described backboard 18 and/or gripper shoe 16 are additionally provided with pipeline perforation 33.
U-shaped draw-in groove 36 and installing hole 35 is offered on described base plate 20.
With reference to Fig. 8, described glass tubing fixation clamp 7 is made up of first clamping plate the 38, second clamping plate 41 and snap close 42, the end face that described first clamping plate 38 and the second clamping plate 41 contact with each other is provided with several clamp groove 40 for placing vertical glass tubing 8, is additionally provided with, in described clamp groove 40, the cushion course that shape adapts with clamp groove 40.Described first clamping plate 38 are provided with the second through hole, the middle part of described first clamping plate 38 and the second clamping plate 41 side is provided with connection fixing hole 43, described snap close 42, by being fixed on the first clamping plate 38 and side of the second clamping plate 41 through the screw connecting fixing hole 43, fixes the first clamping plate 38 and the second clamping plate 41 for buckle.
The middle part of described digestion reaction room 3 is provided with one piece of dividing plate, is provided with wind-tunnel in the middle of dividing plate；Described digestion reaction room 3 is divided into first half and latter half by described dividing plate, and described first half is connected by described wind-tunnel with latter half；The left and right sides of described first half further respectively has baffle plate, and baffle plate is provided with multiple air holes；The baffle plate in the left side being positioned at first half is connected with described latter half with casing 2 outer wall enclosed space, and the baffle plate on right side being positioned at first half is connected with described latter half with the intermediate plate enclosed space of casing 2；Described constant temperature air bath shaking table 6 includes that shaking table, electric fan, electric heater, described shaking table are arranged in described first half, and described electric fan is arranged at described wind-tunnel, and described electric heater is arranged in described latter half；Described Bionic digestion device 4 is fixedly mounted on the top of described shaking table.
With reference to Fig. 9, described shaking table includes that shaking table drives motor 51, major axis 48, short axle 46, fixed plate 49, pallet fixed plate 44, and shaking table drives motor 51, major axis 48 and short axle 46 to be arranged on the diverse location of fixed plate 49；Major axis 48 and short axle 46 both pass through fixed plate 49, and one end of major axis 48 is provided with the first belt pulley (sign), and the other end is connected with pallet fixed plate 44, and one end of short axle 46 is connected with pallet fixed plate 44；Shaking table drives the fixing end of motor 51 to be arranged in fixed plate 49, and round end connects the second belt pulley 53；Described first belt pulley (sign) is linked together by belt 52 with the second belt pulley 53.
Described major axis 48 and short axle 46 are eccentric shaft；The quantity of described major axis 48 is one, and the quantity of short axle 46 is two；Major axis 48 and two short axles 46 shaped formation in equilateral triangle is arranged in fixed plate 49, and the triangle that i.e. major axis 48 axle center and 3, two short axle 46 axle center line are formed is equilateral triangle；Described fixed plate 49 is being equipped with the first installing hole 45 for installing major axis 48 and short axle 46 with major axis 48, short axle 46 corresponding section, and major axis 48 and short axle 46 are arranged in fixed plate 49 through the first installing hole 45 by screw 47；It is mounted on bearing 54 on described major axis 48, short axle 46；Fixed plate 49 is provided with the second installing hole 50 driving motor 51 for installing shaking table.
Described automatic enzyme-added device includes cold closet, peristaltic pump, refrigeration mechanism, is provided with a heat exchanger, a test tube rack and multiple Sheng enzyme pipe in described cold closet, and described heat exchanger and test tube rack are fixedly mounted in described cold closet；Described Sheng enzyme pipe is placed on described test tube rack；Described heat exchanger is connected by refrigerant pipe with described refrigeration mechanism；The upper end of described Sheng enzyme pipe is open end, and each lower end containing enzyme pipe is connected with a defeated enzyme flexible pipe；Described defeated enzyme flexible pipe is connected through the tank wall of described cold closet by the Digestive system input port of described peristaltic pump with described simulation digestive appartus.
Described peristaltic pump is provided with motor, pump seat, drive end bearing bracket, rear end cap, connecting rod, roller bundle, fastener；Described motor is fixedly mounted on described pump seat, and the front end of described pump seat is fixing with the rear end of described rear end cap to be connected, and the front end of described rear end cap is connected by described connecting rod is fixing with the rear end of described drive end bearing bracket；Described roller bundle is provided with many rollers, and roller bundle is arranged between described drive end bearing bracket and rear end cap, the rear end of roller bundle and described motors, and is driven roller bundle around the central axis of roller bundle by motor；Described fastener is across above described roller bundle, and the lower end of fastener is fixing with described connecting rod to be connected, and is provided with through hole in fastener, and described defeated enzyme flexible pipe is connected through described through hole with the Digestive system input port of described simulation digestive appartus.
Embodiment
2
See figures.1.and.2 and Figure 10 ~ 12, a kind of full-automatic nonruminant gastrointestinal tract Bionic digestion system of the present embodiment, compared with the full-automatic nonruminant gastrointestinal tract Bionic digestion system described in embodiment 1, there is following difference:
Described vertical simulation digestive appartus is made up of the dialysis simulation digestive tube of 2 groups, often group 5 series connection.
With reference to Figure 11, described dialysis simulation digestive tube includes vertical glass tubing 8 and Dialysis tubing 60, and Dialysis tubing 60 is placed in this vertical glass tubing 8；Described vertical glass tubing 8 is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground, and its side bottom and upper end are respectively equipped with the first input pipe 56 and the first outlet tube 57；The two ends of Dialysis tubing 60 are stretched out at two grounds of this vertical glass tubing 8 respectively and are turned up, Dialysis tubing 60 end being exposed to outside ground of turning up is tied up by rubber bar and is fixed on ground, ground after hollow tube upper and lower side ties up Dialysis tubing 60 end is plugged with the silica gel plug 59 with at least tube for transfusion 58 and solid silicon plug 55 respectively, offers the groove 29 placing actuating device in the middle part of the described silica gel plug with at least tube for transfusion 58.The first input pipe 56 on dialysis simulation digestive tube is buffer input port, first outlet tube 57 is buffer delivery outlet, in two adjacent dialysis simulation digestive tubes, the buffer input port of a forward dialysis simulation digestive tube is connected by infusion tube with the buffer delivery outlet of another dialysis simulation digestive tube, and all of dialysis simulation digestive tube is sequentially connected in series by described infusion tube；The buffer delivery outlet of the most forward dialysis simulation digestive tube, the buffer input port of dialysis simulation digestive tube the most rearward are connected with described buffer circulating device by tube for transfusion 58 respectively.The middle part of described tube for transfusion 58 is provided with check valve, and the end of tube for transfusion 58 is provided with snap joint, and described snap joint is described Digestive system input port.The Digestive system input port of each described dialysis simulation digestive tube is connected by flexible pipe with described automatic enzyme-added device.
With reference to Figure 12, described actuating device includes that magnetic core 68, magnetic core 68 fix seat 65 and connecting shaft 61；Described magnetic core 68 is fixed and is provided with magnetic loop cover 66 outside seat 65；Described magnetic core 68 is fixed seat 65 by bearing 67 with magnetic core 68 and is connected；The bottom of described magnetic core 68 is connected with groove 29 matched in clearance；The upper end of described connecting shaft 61 is set in outside magnetic core 68, its bottom and the hollow top clamping of stirring rod 11.
Described actuating device is provided with the first sealing ring 62 with the junction of the silica gel plug 59 with tube for transfusion.
Being arranged with motor cover 64 on described motor, the bottom of described motor cover 64 is connected with motor fixing seat 64, and described motor fixing seat 64 is made up of upper seal bootr 64-1 and lower seal bootr 64-2.
Embodiment
3
With reference to Fig. 1, Fig. 2, Figure 13 ~ 15, a kind of full-automatic nonruminant gastrointestinal tract Bionic digestion system of the present embodiment, compared with the full-automatic nonruminant gastrointestinal tract Bionic digestion system described in embodiment 2, there is following difference:
With reference to Figure 13 ~ 15, described actuating device includes outer magnetic ring set 71, outer magnetic ring 72, isolation cover 73, internal magnetic ring 74 and internal magnetic ring pitman 76；Described outer magnetic ring set 71 is fixed with the output shaft of motor 15, upper seal bootr 64-1 and is connected；Described outer magnetic ring set 71 is embedded in outer magnetic ring 72；It is provided with isolation cover 73 between described internal magnetic ring 74 and outer magnetic ring 72；Described internal magnetic ring 74 is arranged in isolation cover 73；One end of described internal magnetic ring pitman 76 snaps in internal magnetic ring 74, and its other end is inserted through lower seal bootr 64-2 and silica gel plug, is connected with the top of stirring rod 11.
Described Bionic digestion device also includes the pumping peristaltic pump 69 being connected with the first input pipe 56 and the pumping peristaltic pump 70 being connected with the first outlet tube 57.
It is provided with the second sealing ring 75 between described upper seal bootr 64-1 and lower seal bootr 64-2, is bolted to connection.
Embodiment
4
, compared with the full-automatic nonruminant gastrointestinal tract Bionic digestion system described in embodiment 1, there is following difference in a kind of full-automatic nonruminant gastrointestinal tract Bionic digestion system of the present embodiment:
Described vertical simulation digestive appartus is made up of the dialysis simulation digestive tube of 5 series connection and the double glazing simulation digestive tube of 5 series connection.
Dialysis simulation digestive tube is with described in embodiment 2.
A kind of full-automatic nonruminant gastrointestinal tract Bionic digestion system described in embodiment 2 and 3, its operation principle: by the stirring action of stirring rod 11 in the concussion of constant temperature air bath shaking table 6 and dialysis simulation digestive tube, simulate nonruminant stomach, small intestinal, the large intestine digestion process to Feed Sample.
Its using method:
Compared with the method that the Bionic digestive system for monogastric animals described in CN 101482460 A simulates nonruminant digestion, there is following difference:
The concrete operations of the 1-3 in preparation process are: open constant temperature air bath shaking table 6, dialysis simulation digestive tube on first fixed support starts concussion, simultaneously, start the motor 15 on dialysis simulation digestive tube, stirring rod 11 in dialysis simulation digestive tube stirs the Feed Sample in Dialysis tubing 60, strengthens the mixing between Feed Sample and Digestive system and the adequacy of digestion reaction in follow-up Bionic digestion step.
During Bionic digestion: Feed Sample loads Dialysis tubing, stomach simulated digestive juice is injected in Dialysis tubing by tube for transfusion.Then, there is the stomach buffer of a design temperature, at the input pipe with simulation digestive tube, under the effect pumping peristaltic pump and pumping peristaltic pump that outlet tube connects, inject in vertical glass tubing via input pipe, then flow out vertical glass tubing via outlet tube, and the power of pumping peristaltic pump is less than the power of pumping peristaltic pump, make between vertical glass tubing and the Dialysis tubing of simulation digestive tube, to form relatively low negative pressure (such as-0.01MPa ~-0.04MPa), and the liquid level of reactant liquor does not produce fluctuation in bag filter, make that the sample to be digested in bag filter is non-sticky to be adhered on Dialysis tubing tube wall, reduce the error of simulation digestion process.Like this, the stomach buffer of certain volume is such vertical glass tubing of inflow and outflow circularly within the setting time, meanwhile, the magnetic core of driven by motor magnetic drive device is fixed seat relative to magnetic core and is done cutting magnetic line movement, and then magnetic core rotates, and drive stirring rod to rotate by connecting shaft, or, driven by motor outer magnetic ring set and outer magnetic ring rotate, outer magnetic ring is made to produce rotating excitation field in isolation cover, drive internal magnetic ring rotates, snapping in the internal magnetic ring pitman in internal magnetic ring drives stirring rod to rotate, and then realize the stirring of the Feed Sample in bag filter with stomach simulated digestive juice is mixed, rotating speed >=the 100r/min of stirring rod, guarantee to realize between stomach simulated digestive juice and Feed Sample sealing stirring in vertical glass pipe, it is sufficiently mixed, complete the simulation digestion process that stomach stage chyme is wriggled.nullIn this setting time，Digestion reaction is there is in the stomach simulated digestive juice being under stirring and Feed Sample in Dialysis tubing，The digestion product produced is flowed out by the molecular sieve of Dialysis tubing and carries out mass exchange with the stomach buffer in vertical glass tubing，Digestion product dissolves in and can not return in stomach buffer in Dialysis tubing that (digestion product i.e. produced is taken away by stomach buffer，So that produce digestion product do not interfere with Dialysis tubing in carry out subsequently other reaction)，Dialysis tubing has left behind indigested product，Then，The stomach buffer dissolved with digestion product in vertical glass tubing is all discharged，Deionized water is injected in vertical glass tubing via input pipe by pumping peristaltic pump，Vertical glass tubing is flowed out through pumping peristaltic pump by outlet tube after and，Like this，The vertical glass tubing of the deionized water of certain volume inflow and outflow circularly is for several times，So that the digestion product of residual in the stomach buffer remained in vertical glass tubing and Dialysis tubing is cleaned up，Thus complete the simulation digestion process of stomach.
A kind of full-automatic nonruminant gastrointestinal tract Bionic digestion system described in embodiment 1, its operation principle: by the stirring action of stirring rod 11 in the concussion of constant temperature air bath shaking table 6 and double glazing simulation digestive tube, simulate nonruminant stomach, small intestinal, the large intestine digestion process to Feed Sample.Digestive system reconvert after having digested is to dialysis in dialysis simulation digestive tube, the absorption process of simulation nutrient.
Its using method: with the Bionic digestive system for monogastric animals described in example 2 and 3 compared with simulate the method for nonruminant digestion, there is following difference:
The concrete operations of the 1-3 in preparation process are: open constant temperature air bath shaking table 6, double glazing simulation digestive tube on first fixed support starts concussion, simultaneously, start the motor 15 on double glazing simulation digestive tube, the Feed Sample in stirring rod 11 stirred glass inner tube 26 in double glazing simulation digestive tube, strengthens the mixing between Feed Sample and Digestive system and the adequacy of digestion reaction in follow-up Bionic digestion step.
nullAfter question response terminates，Digestive system under the effect of pumping peristaltic pump 70 through lower end enzyme-added pipe 9 or manually transfer to dialysis simulation digestive tube inner filtration，Stomach/small intestinal buffer outside making the digestion product in Dialysis tubing 60 with Dialysis tubing 60 carries out mass exchange，Digestion product dissolves in and can not return in stomach/small intestinal buffer in Dialysis tubing 60 that (digestion product i.e. produced is taken away by stomach buffer，So that produce digestion product do not interfere with Dialysis tubing 60 in carry out subsequently other reaction)，Bag filter has left behind indigested product，Then，The stomach dissolved with digestion product/small intestinal buffer in dialysis simulation digestive tube is all discharged，Deionized water is injected in vertical glass tubing 8 via input pipe by pumping peristaltic pump 69，Vertical glass tubing 8 is flowed out through pumping peristaltic pump 70 by outlet tube after and，Like this，The vertical glass tubing of the deionized water of certain volume inflow and outflow circularly 8 is for several times，So that the stomach buffer of residual in vertical glass tubing 8 and the digestion product of the interior residual of Dialysis tubing 60 are cleaned up，Thus complete the simulation digestion process of stomach/small intestinal.
Claims (10)
1. a full-automatic Bionic digestive system for monogastric animals, it is characterized in that, including casing, constant temperature air bath shaking table, Bionic digestion device, automatic enzyme-added device, buffer circulating device, clean device, control circuit, the upper left side of described casing is provided with digestion reaction room, and it is indoor that described constant temperature air bath shaking table device is located at digestion reaction；Described automatic enzyme-added device is fixedly mounted in casing, and automatic enzyme-added device is connected by tube for transfusion with Bionic digestion device；Described buffer circulating device and cleaning device are located at the lower section of casing, and buffer circulating device, cleaning device are connected with Bionic digestion device by tube for transfusion respectively；Described control circuit is located in casing, and be connected with constant temperature air bath shaking table device, automatic enzyme-added device, buffer circulating device, cleaning device by wire, described control circuit is connected with the industrial computer being arranged in casing, and described industrial computer is connected with being arranged on the top-right display of casing；Described Bionic digestion device is vertically installed at above constant temperature air bath shaking table.
2. the most full-automatic Bionic digestive system for monogastric animals, it is characterised in that described Bionic digestion device includes fixed support, vertical simulation digestive appartus, glass tubing fixation clamp, stirring rod, motor and actuating device；Described vertical simulation digestive appartus is simulated digestive tube by the dialysis of several series connection and/or double glazing simulation digestive tube forms；Described vertical simulation digestive appartus vertically clamps and is arranged in described glass tubing fixation clamp, and described stirring rod is arranged in vertical simulation digestive tube, and its top removably connects with actuating device；Described actuating device electrically connects with the motor being arranged on fixed support top；Described glass tubing fixation clamp is fixedly mounted in the middle part of fixed support.
3. the most full-automatic Bionic digestive system for monogastric animals, it is characterized in that, glass inner tube and enzyme-added pipe that described double glazing simulation digestive tube by vertical glass tubing, is set in hollow tube form, described vertical glass tubing is a hollow tube, described hollow tube upper and lower side is respectively provided with a ground, is plugged with sealing-plug in ground；Hollow tube side wall lower ends and upper end are respectively equipped with the second input pipe and the second outlet tube；Described enzyme-added pipe is through hollow tube sidewall and extends in glass inner tube, and hollow tube inner space is separated into outer cavity volume and content cavity by glass inner tube.
4. the most full-automatic Bionic digestive system for monogastric animals, it is characterised in that described actuating device includes connecting bushing and heightens drive link, and described connecting bushing is set on motor output shaft, synchronously rotates with motor；The described bottom heightening drive link is connected with stirring rod, and its top is fixed in the chute below connecting bushing by screw rod socket, and making to heighten drive link can move up and down in connecting bushing；Described drive link of heightening is provided with locking nut, for heightening the locking degree between drive link and stirring rod.
5. the most full-automatic Bionic digestive system for monogastric animals, it is characterized in that, described drive link of heightening includes the body of rod and jaw, one end of the described body of rod is fixing with jaw to be connected, body of rod outer wall near jaw is provided with external screw thread, external screw thread matches with the female thread of the locking nut for regulating jaw locking degree, and the one end away from jaw at least offers 2 for the fixing hole installing screw rod；It is additionally provided with groove in the middle part of the described body of rod.
6. full-automatic Bionic digestive system for monogastric animals as described in Claims 2 or 3, it is characterised in that described fixed support is made up of base plate, lower frame plate, backboard, side plate and gripper shoe, described base plate is fixing with lower frame plate to be connected；Described lower frame plate is by one piece of metallic plate bending and molding, and including a horizontal fixed plate and two pieces of risers erect, two risers are positioned at below horizontal fixed plate, and is connected with two ends, the left and right one of horizontal fixed plate；The lower end of riser is all bent up being converted into fixed block, and fixing hole is provided with hole, location；The first through hole for fixing vertical glass tubing fixation clamp is offered on horizontal fixed plate, described backboard, side plate are fixed on the back upper place of lower frame plate, the top of described backboard and side plate is fixing with gripper shoe to be connected, and described gripper shoe is additionally provided with motor fixing threaded hole and motor shaft perforation；Described backboard, side plate and gripper shoe are provided with passage, and described backboard and/or gripper shoe are additionally provided with pipeline perforation；U-shaped draw-in groove and installing hole is offered on described base plate.
7. full-automatic Bionic digestive system for monogastric animals as described in Claims 2 or 3, it is characterized in that, described glass tubing fixation clamp is made up of the first clamping plate, the second clamping plate and snap close, the end face that described first clamping plate and the second clamping plate contact with each other is provided with several clamp groove for placing vertical glass tubing, is additionally provided with the cushion course that shape adapts with clamp groove in described clamp groove；
Described first clamping plate are provided with the second through hole, the middle part of described first clamping plate and the second clamping plate side is provided with connection fixing hole, described snap close, by being fixed on the first clamping plate and the side of the second clamping plate through the screw connecting fixing hole, fixes the first clamping plate and the second clamping plate for buckle.
8. the most full-automatic Bionic digestive system for monogastric animals, it is characterised in that described dialysis simulation digestive tube includes vertical glass tubing and Dialysis tubing, and Dialysis tubing is placed in this vertical glass tubing；Described vertical glass tubing is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground, and its side bottom and upper end are respectively equipped with the first input pipe and the first outlet tube；The two ends of Dialysis tubing are stretched out at the two of this vertical glass tubing grounds respectively and are turned up, the Dialysis tubing end being exposed to outside ground of turning up is tied up by rubber bar and is fixed on ground, ground after hollow tube upper and lower side ties up Dialysis tubing end is plugged with the silica gel plug with at least tube for transfusion and solid silicon plug respectively, offers the groove placing actuating device in the middle part of the described silica gel plug with at least tube for transfusion.
9. the most full-automatic Bionic digestive system for monogastric animals, it is characterised in that described actuating device includes that magnetic core, magnetic core fix seat and connecting shaft；Described magnetic core is fixed and is provided with magnetic loop cover outside seat；Described magnetic core is fixed seat by bearing with magnetic core and is connected；The bottom of described magnetic core is connected with groove matched in clearance；The upper end of described connecting shaft is set in outside magnetic core, its bottom and the hollow top clamping of stirring rod.
10. the most full-automatic Bionic digestive system for monogastric animals, it is characterised in that described actuating device includes outer magnetic ring set, outer magnetic ring, isolation cover, internal magnetic ring and internal magnetic ring pitman；Described outer magnetic ring set is fixed with the output shaft of motor, upper seal bootr and is connected；Described outer magnetic ring is nested and is located in outer magnetic ring；It is provided with isolation cover between described internal magnetic ring and outer magnetic ring；Described internal magnetic ring is arranged in isolation cover；One end of described internal magnetic ring pitman snaps in internal magnetic ring, and its other end is inserted through lower seal bootr and silica gel plug, is connected with the top of stirring rod.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610426936.XA CN105891428B (en) | 2016-06-16 | 2016-06-16 | A kind of full-automatic Bionic digestive system for monogastric animals |
| PCT/CN2017/087400 WO2017215498A1 (en) | 2016-06-16 | 2017-06-07 | Fully-automatic bionic digestive system for monogastric animals |
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| CN201610426936.XA CN105891428B (en) | 2016-06-16 | 2016-06-16 | A kind of full-automatic Bionic digestive system for monogastric animals |
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| CN105891428B CN105891428B (en) | 2018-05-25 |
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| WO2017215498A1 (en) | 2017-12-21 |
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