CN205786549U - A kind of vertical animal gastrointestinal tract Bionic digestion device - Google Patents
A kind of vertical animal gastrointestinal tract Bionic digestion device Download PDFInfo
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- CN205786549U CN205786549U CN201620581819.6U CN201620581819U CN205786549U CN 205786549 U CN205786549 U CN 205786549U CN 201620581819 U CN201620581819 U CN 201620581819U CN 205786549 U CN205786549 U CN 205786549U
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Abstract
A kind of vertical animal gastrointestinal tract Bionic digestion device, including simulation digestive tube, stirring rod, motor and magnetic drive device；Described simulation digestive tube includes vertical glass tubing and Dialysis tubing, and Dialysis tubing is placed in this vertical glass tubing；Described stirring rod is arranged in Dialysis tubing, and its top removably connects with magnetic drive device；Described magnetic drive device is arranged on above the silica gel plug on simulation digestive tube top, electrically connects with motor；Described motor is arranged on above magnetic drive device by motor fixing seat.This utility model vertical animal gastrointestinal tract Bionic digestion device, simple in construction, easy to use, Bionic digestion reactant liquor can be avoided to reveal, the accuracy and reproducible of simulation digestion, error is little.
Description
Technical field
This utility model relates to a kind of Bionic digestion experiment equipment, especially relates to a kind of vertical animal gastrointestinal tract bionical
Slaking apparatus.
Background technology
In modern farming, the objective nutrient biological value accurately evaluating feedstuff determines that Animal nutrition needs
Measure and optimize the primary decision-making basis of feed formula.From the sixties in 20th century, people are attempting passing through conditions in vitro always
The digestion in animal gastrointestinal tract of the Imitating feedstuff realizes the rapid evaluation to feed nutrient biological value.
Prior art generally use triangular flask or test tube as gastrointestinal tract Bionic digestion device.It is simulated digestion experiment
Time, first the feedstuff of constant weight is loaded in triangular flask or test tube, in triangular flask or test tube, then add simulated gastric fluid or intestinal
Liquid, then after, triangular flask or test tube are placed on water bath with thermostatic control shaking table vibration digestion a period of time, this process is simulation animal
Stomach or the digestion process of intestinal, after digestion terminates, centrifuged or filtered again goes out oneself digestion material and undigested material, when not disappearing
When the weight of compound matter is higher relative to the weight of Feed Sample, represent that digestibility is low.Use triangular flask or test tube as gastrointestinal
During road Bionic digestion device, owing to the digestion product in triangular pipe or test tube has inhibitory action to digestion reaction, cause this kind of mould
The digestive efficiency intending digestion experiment is generally low than the measured value in animal body, affects the accurate survey to feed nutrient biological value
Comment.
Compared with triangular flask or test tube as Simulative digestive device for gastrointestinal tract of animals, the eighties in 20th century Canada scholar
Gauther etc., Savoie etc. establish with Dialysis tubing (aperture 1000Da ~ 14000Da is optional), flowing dialysis solution system, stirring
Device, water bath with thermostatic control system are the pig small intestine simulation digestive appartus of ingredient.
Additionally, CN 201344874Y discloses a kind of Simulative digestive device for gastrointestinal tract of animals, it includes glass tubing and dialysis
Pipe, this glass tubing is a hollow tube, this body be respectively arranged at the two ends with a ground, the side of this body is provided with input pipe and output
Pipe, this Dialysis tubing is placed in this glass tubing, and the two ends of this Dialysis tubing are stretched out and outer respectively at the two of this glass tubing grounds
Turning over, the Dialysis tubing end being exposed to outside ground of turning up is tied up by rubber bar and is fixed on ground, ties up two behind Dialysis tubing end
Individual ground is plugged with a rubber stopper and respectively with the rubber stopper of tube for transfusion.
CN 104020264 A discloses a kind of gastrointestinal tract Bionic digestion device, including a support, multiple simulation digestion
Device, a Multi-hole-site test tube clamp, the plurality of simulation digestive appartus is clamped in described Multi-hole-site test tube clamp, described multi-hole position test tube
Folder is fixedly mounted on described support；Each described simulation digestive appartus is provided with buffer input port, buffer delivery outlet and disappears
Change liquid input port；In adjacent two simulation digestive appartus, the buffer input port of a forward simulation digestive appartus and another
The buffer delivery outlet of simulation digestive appartus is connected by infusion tube, and all of simulation digestive appartus is gone here and there successively by described infusion tube
Connection.
The most several employing Dialysis tubings are as the device of animal gastrointestinal tract Bionic digestion, but this Dialysis tubing is horizontal being placed in
Simulate digestion process in air bath shaking table or in shaking bath, easily because of in Dialysis tubing feedstuff in digestion process aerogenesis and
The problems such as the rubber stopper causing Bionic digestion tube end outwards comes off, reactant liquor leakage, secondly, during Bionic digestion, treat
Sample digestion easily sticks and causes bag filter blocked on bag filter, and then affects the digestion effect of Feed Sample.
Utility model content
The technical problems to be solved in the utility model is: overcome the deficiencies in the prior art, it is provided that a kind of simple in construction, uses
Convenient, the vertical animal gastrointestinal tract Bionic digestion device that Bionic digestion reactant liquor is revealed can be avoided.
This utility model solves its technical problem and be the technical scheme is that a kind of vertical animal gastrointestinal tract Bionic digestion
Device, including simulation digestive tube, stirring rod, motor and magnetic drive device；Described simulation digestive tube include vertical glass tubing and
Dialysis tubing, Dialysis tubing is placed in this vertical glass tubing；Described stirring rod is arranged in Dialysis tubing, and its top fills with magnetic drives
Put and removably connect；Described magnetic drive device is arranged on above simulation digestive tube, electrically connects with motor；Described motor is by electricity
Machine is fixed seat and is arranged on above magnetic drive device.
Further, described vertical glass tubing is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground, its side
Bottom face and upper end is respectively equipped with input pipe and outlet tube；The two ends of Dialysis tubing are respectively at two grounds of this vertical glass tubing
Stretching out and turn up, the Dialysis tubing end being exposed to outside ground of turning up is tied up by rubber bar and is fixed on ground, and hollow tube is upper and lower
Ground after end ties up Dialysis tubing end is plugged with respectively with at least tube for transfusion (preferably, the quantity of tube for transfusion is 2 ~ 6)
Silica gel plug and solid silicon plug, offer placement magnetic drive device in the middle part of the described silica gel plug with at least tube for transfusion
Groove.
Further, described magnetic drive device includes that seat fixed by magnetic core, magnetic core；Described magnetic core is fixed and is provided with magnet ring outside seat
Cover；Described magnetic core is fixed seat by bearing with magnetic core and is connected；The bottom of described magnetic core is connected with groove matched in clearance.
Further, described vertical animal gastrointestinal tract Bionic digestion device also include being fixed on magnetic drive device with defeated
First sealing ring of the junction of the silica gel plug of liquid pipe.
Further, described stirring rod is connected with magnetic drive device by connecting shaft, and the upper end of described connecting shaft is set in
Outside magnetic core, its bottom and the hollow top clamping of stirring rod.Preferably, described connecting shaft is silica gel tube.
Further, described magnetic drive device includes that outer magnetic ring set, outer magnetic ring, isolation cover, internal magnetic ring and internal magnetic ring connect
Rod；Described outer magnetic ring set is fixed with motor output shaft, upper seal bootr and is connected；Described outer magnetic ring is nested and is located in outer magnetic ring；Described
Isolation cover it is provided with between internal magnetic ring and outer magnetic ring；Described internal magnetic ring is arranged in isolation cover；One end of described internal magnetic ring pitman
Snapping in internal magnetic ring, its other end is inserted through lower seal bootr and silica gel plug, is connected with the top of stirring rod.
Further, described motor being arranged with motor cover, the bottom of described motor cover is connected with motor fixing seat, described electricity
Machine is fixed seat and is made up of upper seal bootr and lower seal bootr, is provided with the second sealing ring, passes through spiral shell between upper seal bootr and lower seal bootr
Bolt is fixing to be connected.
Further, described vertical animal gastrointestinal tract Bionic digestion device also include the pumping peristaltic pump that is connected with input pipe and
The pumping peristaltic pump being connected with outlet tube.
Operation principle and the using method of a kind of vertical animal gastrointestinal tract Bionic digestion device of this utility model be: by feedstuff
Sample loads Dialysis tubing, and stomach simulated digestive juice is injected in Dialysis tubing by tube for transfusion.Then, there is the stomach buffering of a design temperature
Liquid, under the effect pumping peristaltic pump and pumping peristaltic pump being connected with the simulation input pipe of digestive tube, outlet tube, via input
Pipe injects in vertical glass tubing, then flows out vertical glass tubing via outlet tube, and the power of pumping peristaltic pump is compacted less than pumping
The power of dynamic pump, make to be formed between vertical glass tubing and the Dialysis tubing of simulation digestive tube relatively low negative pressure (as-0.01MPa ~-
0.04MPa), and in bag filter, the liquid level of reactant liquor does not produce fluctuation, makes that the sample to be digested in bag filter is non-sticky to be adhered to
On analysis tube wall, reduce the error of simulation digestion process.Like this, the stomach buffer of certain volume is such within the setting time
The vertical glass tubing of inflow and outflow circularly, meanwhile, the magnetic core of driven by motor magnetic drive device is fixed relative to magnetic core
Seat does cutting magnetic line movement, and then magnetic core rotates, and drives stirring rod to rotate by connecting shaft, or, the outer magnetic of driven by motor
Ring set and outer magnetic ring rotate, and make outer magnetic ring produce rotating excitation field in isolation cover, drive internal magnetic ring to rotate, snap in internal magnetic ring
Internal magnetic ring pitman drives stirring rod to rotate, and then realizes mixing the stirring of the Feed Sample in bag filter with stomach simulated digestive juice
Close, the rotating speed >=100r/min of stirring rod, it is ensured that realize between stomach simulated digestive juice and Feed Sample sealing in vertical glass pipe
Stirring, is sufficiently mixed, and completes the simulation digestion process that stomach stage chyme is wriggled.In this setting time, it is under stirring
Stomach simulated digestive juice and Feed Sample in Dialysis tubing, there is digestion reaction, the digestion product of the generation molecule by Dialysis tubing
Sieve flows out and carries out mass exchange with the stomach buffer in vertical glass tubing, and digestion product dissolves in and can not return in stomach buffer
In Dialysis tubing, (digestion product i.e. produced is taken away by stomach buffer, so that the digestion product produced does not interferes with in Dialysis tubing
Other reactions carried out subsequently), Dialysis tubing left behind indigested product, then, by vertical glass tubing dissolved with disappearing
The stomach buffer changing product is all discharged, and deionized water is injected in vertical glass tubing via input pipe by pumping peristaltic pump, and
Being flowed out vertical glass tubing by pumping peristaltic pump by outlet tube, like this, the deionized water of certain volume flows into circularly
Flow out vertical glass tubing for several times, clear with the digestion product of residual in the stomach buffer that will remain in vertical glass tubing and Dialysis tubing
Wash clean, thus complete the simulation digestion process of stomach.
When needing the simulation digestion carrying out small intestine site, above-mentioned stomach simulated digestive juice is replaced by small intestinal simulation digestion
Liquid, stomach buffer exchange is small intestinal buffer, and situation about wriggling according to digesta into duodenum, sets stirring of small intestinal simulation digestion phase
Mixing the rotating speed of rod, other operations simulate digestion process with stomach, and then complete the simulation digestion of small intestine site.
When needing the simulation digestion being carried out continuously harmonization of the stomach small intestinal, after the operation completing stomach simulation digestion process, the most right
Simulation digestive tube is carried out, then it is consistent with the ion concentration in Dialysis tubing to regulate vertical glass tubing with small intestinal buffer, builds
The external environment of small intestinal simulation digestion, is then injected small intestinal simulated digestive juice in Dialysis tubing by tube for transfusion, and eats according to small intestinal
Rotten situation about wriggling, sets the rotating speed of the stirring rod of small intestinal simulation digestion phase, proceeds small intestinal simulation digestion process operation.
The beneficial effect of a kind of vertical animal gastrointestinal tract Bionic digestion device of this utility model:
1) compared with existing gastrointestinal tract Bionic digestion device, the vertical glass tubing simulation animal of sheathed Dialysis tubing in using
Pipe intestinal digesting environment, due to vertical display when vertical glass tubing uses, its upper end does not exist in liquid, only simulation digestive tube
The gas that residual and digestion reaction produce, in vertical glass tubing, gas is more weak to the active force of silica gel plug, and silica gel plug exists
The gravity of effect downwards, therefore during using, the gas that simulation digestion produces is difficult to silica gel plug from vertical glass tubing end
Come off in ground, the glass tubing of traverse in prior art can be prevented effectively from and lead because of digestion reaction aerogenesis in simulation digestion process
Cause the phenomenon that rubber stopper comes off, reactant liquor is revealed at glass tubing two ends, improve the Stability and veracity of Bionic digestion；
2) this gastrointestinal tract Bionic digestion device is combined by magnetic drive device and stirring rod, it is achieved Feed Sample and mould
Intend the stirring mixing between Digestive system, reach the simulation that in digestion process, chyme is wriggled, by regulating the mixing speed of stirring rod,
Complete the simulation digestion process of different parts different phase；
3) pumping-extraction mode that the pumping peristaltic pump connected with input pipe, outlet tube and pumping peristaltic pump are combined is used,
And the power of pumping peristaltic pump is less than the power of pumping peristaltic pump, control the simulation digestion buffer stream by vertical glass tubing
Speed, and make to be formed between vertical glass tubing and Dialysis tubing relatively low negative pressure, make Dialysis tubing in parting open state a little, disappearing in Dialysis tubing
The liquid level changing reactant liquor does not fluctuates；Dialysis tubing will not lean on to stirring rod because of the rotating the liquid stream active force produced of stirring rod
Closely, and then, it is to avoid the stirring rod breakage to Dialysis tubing, extend the service life of Dialysis tubing；Simultaneously, it is to avoid treat that sample digestion is stained with
It is bonded at Dialysis tubing tube wall and causes Dialysis tubing to block, reduce the error of simulation digestion process；
4) first sealing ring or second of magnetic drive device and the junction of the silica gel plug with tube for transfusion it is fixed on
Sealing ring, improves the sealing property of simulation digestive tube, it is ensured that the simulated environment temperature in simulation digestive tube is consistent, can avoid
The phenomenon that digestion reaction liquid occurs evaporation in simulation digestion process and causes digestion reaction liquid to reduce, and then raising simulation disappears
The accuracy changed and repeatability；Also allow for maintaining vertical negative pressure between glass tubing and Dialysis tubing in simulation digestion process；
5) simple in construction, easy to use.
Accompanying drawing explanation
Fig. 1 is the perspective view of a kind of vertical animal gastrointestinal tract Bionic digestion device of this utility model；
Fig. 2 is the front view of a kind of vertical animal gastrointestinal tract Bionic digestion device of this utility model；
Fig. 3 is the sectional view of Section A-A in Fig. 2 (vertical animal gastrointestinal tract Bionic digestion device in embodiment 1)；
Fig. 4 is the enlarged diagram in Fig. 3 at C；
Fig. 5 is the sectional view of section B-B in Fig. 2；
Fig. 6 is the front view of a kind of vertical animal gastrointestinal tract Bionic digestion device in embodiment 2；
Fig. 7 is the sectional view in D-D cross section in Fig. 6；
Fig. 8 is the enlarged diagram in Fig. 7 at E.
Detailed description of the invention
Below in conjunction with drawings and Examples, the utility model is described in further detail.
Embodiment 1
With reference to Fig. 1 ~ 5, the one vertical animal gastrointestinal tract Bionic digestion device of the present embodiment, including simulation digestive tube, stir
Mix rod 9, motor 8 and magnetic drive device 7；Described simulation digestive tube includes vertical glass tubing 3 and Dialysis tubing 10, and Dialysis tubing 10 is put
Put in this vertical glass tubing 3；Described stirring rod 9 is arranged in Dialysis tubing 10, and its top detachably connects with magnetic drive device 7
Connect；Described magnetic drive device 7 is arranged on above simulation digestive tube, electrically connects with motor 8；Described motor 8 is fixed by motor
Seat 13 is arranged on above magnetic drive device 7.
Described vertical glass tubing 3 is a hollow tube, and described hollow tube upper and lower side is respectively provided with a ground 14, at the bottom of its side
Portion and upper end are respectively equipped with input pipe 2 and outlet tube 4；The two ends of Dialysis tubing 10 are respectively from two grounds of this vertical glass tubing 3
Stretching out at 14 and turn up, Dialysis tubing 10 end being exposed to outside ground 14 of turning up is tied up by rubber bar and is fixed on ground 14, in
Ground 14 after blank pipe body upper and lower side ties up Dialysis tubing 10 end is plugged with the silica gel plug 6 with 3 tube for transfusions 5 and solid silicon respectively
Plug 1, offers the groove placing magnetic drive device 7 in the middle part of the described silica gel plug 6 with 3 tube for transfusions 5.
Described input pipe 2 and described outlet tube 4 are centrosymmetric setting relative to the center of described hollow tube.Actual make
Used time, described input pipe 2, described outlet tube 4 lay respectively at lower right, upper left side.
The aperture of described Dialysis tubing 10 is between 700 to 20000 dalton, and described Dialysis tubing 10 is used for containing Feed Sample
And simulated digestive juice；The outer tube diameter of described vertical glass tubing 3 is 40 ~ 100mm, and the tube length of described vertical glass tubing 3 is
180 ~ 300mm, described vertical glass tubing 3 for being passed through buffer or the deionized water cleaned, just via described input pipe 2
Being simulated digestion process in heavy dose of feedstuff, such as, existing gastrointestinal tract Bionic digestion single treatment amount is generally 2 ~ 3g,
And the single treatment amount of the vertical gastrointestinal tract Bionic digestion device after improving is up to more than 20g.
Turn up and be exposed to described Dialysis tubing 10 tip lengths outside described ground 14 between 10 to 25mm.
Described vertical animal gastrointestinal tract Bionic digestion device also includes being fixed on magnetic drive device 7 and with tube for transfusion 5
First sealing ring (sign) of junction of silica gel plug 6.
Described magnetic drive device 7 includes that seat 7-2 fixed by magnetic core 7-4, magnetic core；Described magnetic core is fixed and is provided with outside seat 7-2
Magnetic loop cover 7-1；Described magnetic core 7-4 fixes seat 7-2 by bearing 7-3 with magnetic core and is connected；Between the bottom of described magnetic core 7-4 and groove
Gap is connected.
Seeing Fig. 4, described stirring rod 9 is connected with magnetic drive device 7 by connecting shaft 11, the upper end of described connecting shaft 11
It is set in outside magnetic core 7-4, its bottom and the hollow top clamping of stirring rod 9.Described connecting shaft 11 is silica gel tube.
Being arranged with motor cover 12 on described motor 8, the bottom of described motor cover 12 is connected with motor fixing seat 13, and motor is solid
Reservation 13 is made up of upper seal bootr 13-1 and lower seal bootr 13-2, and upper seal bootr 13-1 and lower seal bootr 13-2 is bolted
Connect.
Embodiment 2
With reference to Fig. 1 ~ 3, Fig. 6 and Fig. 7, the one vertical animal gastrointestinal tract Bionic digestion device of the present embodiment, with embodiment 1
Described vertical animal gastrointestinal tract Bionic digestion device is compared, and there is following difference:
The quantity of described tube for transfusion 5 is 4.
It is provided with the second sealing ring 21 between described upper seal bootr 13-1 and lower seal bootr 13-2, is bolted to connection.
Seeing Fig. 5, described magnetic drive device 7 includes outer magnetic ring set 17, outer magnetic ring 18, isolation cover 19, internal magnetic ring 20 and
Internal magnetic ring pitman 22；Described outer magnetic ring set 17 is fixed with motor output shaft, upper seal bootr and is connected；Described outer magnetic ring set 17 is embedded
In outer magnetic ring 18；It is provided with isolation cover 19 between described internal magnetic ring 20 and outer magnetic ring 18；Described internal magnetic ring 20 is arranged on isolation cover
In 19；One end of described internal magnetic ring pitman 22 snaps in internal magnetic ring 20, and its other end is inserted through lower seal bootr 13-2 and silicon
Plug 6, is connected with the top of stirring rod 9.
Described vertical animal gastrointestinal tract Bionic digestion device also includes the pumping peristaltic pump 15 being connected with input pipe 2 and with defeated
Go out the pumping peristaltic pump 16 that pipe 4 connects.
Below as a example by the digestion of the harmonization of the stomach small intestinal of simulation animal, further illustrate a kind of vertical animal stomach of this utility model
The operation principle of intestinal Bionic digestion device and using method.
When using the peptic digestion of this utility model simulation animal, Feed Sample is loaded Dialysis tubing 10, stomach simulation digestion
Liquid is injected in Dialysis tubing 10 by tube for transfusion 5.Then, there is the stomach buffer of a design temperature, with simulation digestive tube defeated
Enter under the effect of pipe 2, the pumping peristaltic pump 15 of outlet tube 4 connection and pumping peristaltic pump 16, inject vertical glass via input pipe 2
In pipe 3, then flow out vertical glass tubing 3 via outlet tube 4, and the power of pumping peristaltic pump 15 is less than the merit of pumping peristaltic pump 16
Rate, makes to form relatively low negative pressure (such as-0.01MPa) between the vertical glass tubing 3 of simulation digestive tube and Dialysis tubing 10, and bag filter
The liquid level of interior reactant liquor does not produce fluctuation, makes that the sample to be digested in bag filter is non-sticky to be adhered on Dialysis tubing 10 tube wall, reduces
The error of simulation digestion process.Like this, the stomach buffer of certain volume so flows within the setting time circularly
Flowing out vertical glass tubing 3, meanwhile, motor 8 drives the magnetic core 7-4 of magnetic drive device 7 to fix seat 7-2 relative to magnetic core and cuts
Cut magnetic line of force motion, and then magnetic core 7-4 rotates, and drive stirring rod 9 to rotate by connecting shaft 11, or, motor 8 drives outer magnetic
Ring set 17 and outer magnetic ring 18 rotate, and make outer magnetic ring 18 produce rotating excitation field in isolation cover 19, drive internal magnetic ring 20 to rotate, snap in
Internal magnetic ring pitman 22 in internal magnetic ring 20 drives stirring rod 9 to rotate, and then realizes the Feed Sample in bag filter and stomach mould
Intend the stirring mixing of Digestive system, the rotating speed >=100r/min of stirring rod 9, it is ensured that the most mixed between stomach simulated digestive juice and Feed Sample
Close, complete the simulation digestion process that stomach stage chyme is wriggled.In this setting time, the stomach simulation digestion being under stirring
There is digestion reaction in liquid and Feed Sample in Dialysis tubing 10, the digestion product of generation is flowed out also by the molecular sieve of Dialysis tubing 10
Carrying out mass exchange with the stomach buffer in vertical glass tubing 3, digestion product dissolves in and can not return to Dialysis tubing in stomach buffer
In 10 (digestion product i.e. produced is taken away by stomach buffer so that the digestion product produced do not interfere with in Dialysis tubing 10 with
After other reactions of carrying out), Dialysis tubing 10 left behind indigested product, then, by vertical glass tubing 3 dissolved with disappearing
The stomach buffer changing product is all discharged, and deionized water injects vertical glass tubing 3 by pumping peristaltic pump 15 via input pipe 2
In, and after flowed out vertical glass tubing 3 through pumping peristaltic pump 16 by outlet tube 4, like this, the circulation of the deionized water of certain volume is past
The vertical glass tubing of inflow and outflow 3 is for several times again, with residual in the stomach buffer that will remain in vertical glass tubing 3 and Dialysis tubing 10
Digestion product clean up, thus complete the simulation digestion process of stomach.
When using the little intestinal digestion of this utility model simulation animal, Feed Sample loading Dialysis tubing 10, small intestinal is simulated
Digestive system is injected in Dialysis tubing 10 by tube for transfusion 5.Then, there is the small intestinal buffer of a design temperature, digesting with simulation
Under the effect pumping peristaltic pump 15 and pumping peristaltic pump 16 that the input pipe 2 of pipe, outlet tube 4 connect, inject perpendicular via input pipe 2
In straight glass tube 3, then flow out vertical glass tubing 3 via outlet tube 4, and the power of pumping peristaltic pump 15 is less than pumping peristaltic pump
The power of 16, makes to form relatively low negative pressure (such as-0.01MPa) between the vertical glass tubing 3 of simulation digestive tube and Dialysis tubing 10, and
In bag filter, the liquid level of reactant liquor does not produce fluctuation, makes that the sample to be digested in bag filter is non-sticky adheres to Dialysis tubing 10 tube wall
On, reduce the error of simulation digestion process.Like this, the so circulation within the setting time of the small intestinal buffer of certain volume is past
The vertical glass tubing of inflow and outflow 3 again；Meanwhile, motor 8 drives the magnetic core 7-4 of magnetic drive device 7 to fix relative to magnetic core
Seat 7-2 does cutting magnetic line movement, and then magnetic core 7-4 rotates, and drives stirring rod 9 to rotate by connecting shaft 11, or, or
Person, motor 8 drives outer magnetic ring set 17 and outer magnetic ring 18 to rotate, makes outer magnetic ring 18 produce rotating excitation field in isolation cover 19, drive
Internal magnetic ring 20 rotates, and snaps in the internal magnetic ring pitman 22 in internal magnetic ring 20 and drives stirring rod 9 to rotate, and then realizes in bag filter
Feed Sample mix with the stirring of small intestinal simulated digestive juice, according to digesta into duodenum wriggle situation, set stirring rod 9 rotating speed
>=100r/min, it is ensured that be sufficiently mixed between small intestinal simulated digestive juice and Feed Sample, completes the simulation that small intestinal stage chyme is wriggled
Digestion process.In this setting time, the small intestinal simulated digestive juice being under stirring and Feed Sample are in Dialysis tubing 10
Digestion reaction occurs, and the digestion product of generation is flowed out by the molecular sieve of Dialysis tubing 10 and delays with the small intestinal in vertical glass tubing 3
Rushing liquid and carry out mass exchange, digestion product dissolves in and can not return to (the digestion product i.e. produced in Dialysis tubing 10 in small intestinal buffer
Thing is taken away by small intestinal buffer so that produce digestion product do not interfere with Dialysis tubing 10 in carry out subsequently other reaction),
Dialysis tubing 10 leaves behind indigested product, then, by the small intestinal buffer dissolved with digestion product in vertical glass tubing 3
All discharging, deionized water is injected in vertical glass tubing 3 via input pipe 2 by pumping peristaltic pump 15, and after wriggle through pumping
Pump 16 is flowed out vertical glass tubing 3 by outlet tube 4, and like this, the inflow and outflow circularly of the deionized water of certain volume is vertical
Glass tubing 3 for several times, with will in vertical glass tubing 3 residual small intestinal buffer and in Dialysis tubing 10 digestion product of residual clean
Totally, thus complete the simulation digestion process of small intestine site.
When using the little intestinal digestion of harmonization of the stomach of this utility model simulation animal, the operation of peptic digestion dummy run phase is with above-mentioned mould
Intend the peptic digestion process of animal, therefore repeat no more；After stomach simulation digestion process terminates, then, by vertical glass tubing 3
Stomach buffer dissolved with digestion product is all discharged, and deionized water injects vertical glass by pumping peristaltic pump 15 via input pipe 2
In glass pipe 3, then under the effect of pumping peristaltic pump 16, flow out glass tubing via outlet tube 4, like this, certain volume go from
The vertical glass tubing of sub-water inflow and outflow circularly 3 for several times, with will in vertical glass tubing 3 residual stomach buffer and dialysis
In pipe 10, the digestion product of residual cleans up.Then, within the second setting time, will have the small intestinal buffer of uniform temperature
Inject by pumping peristaltic pump 15 input pipe 2 from vertical glass tubing 3 that moves in circles, flow from the outlet tube 4 of vertical glass tubing 3
Go out, so that vertically glass tubing 3 is equal with the ion concentration in Dialysis tubing 10, build small intestinal digestive environments.Then, small intestinal is simulated
Digestive system injects in Dialysis tubing 10 by tube for transfusion 5, and subsequent operation is with the simulated operation of above-mentioned small intestine site digestion process.
Claims (9)
1. a vertical animal gastrointestinal tract Bionic digestion device, it is characterised in that include simulate digestive tube, stirring rod, motor and
Magnetic drive device；Described simulation digestive tube includes vertical glass tubing and Dialysis tubing, and Dialysis tubing is placed in this vertical glass tubing；
Described stirring rod is arranged in Dialysis tubing, and its top removably connects with magnetic drive device；Described magnetic drive device is installed
Above the silica gel plug on simulation digestive tube top, electrically connect with motor；Described motor is arranged on magnetic force by motor fixing seat and passes
Above dynamic device.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 1, it is characterised in that described vertical glass tubing is one
Hollow tube, described hollow tube upper and lower side is respectively provided with a ground, and its side bottom and upper end are respectively equipped with input pipe and output
Pipe；The two ends of Dialysis tubing are stretched out at the two of this vertical glass tubing grounds respectively and are turned up, turn up be exposed to outside ground saturating
Analysis tube end is tied up by rubber bar and is fixed on ground, and the ground after hollow tube upper and lower side ties up Dialysis tubing end is plugged with respectively
With silica gel plug and the solid silicon plug of at least tube for transfusion, offer in the middle part of the described silica gel plug with at least tube for transfusion
There is the groove placing magnetic drive device.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 2, it is characterised in that described magnetic drive device bag
Include magnetic core, seat fixed by magnetic core；Described magnetic core is fixed and is provided with magnetic loop cover outside seat；Described magnetic core fixes seat even by bearing and magnetic core
Connect；The bottom of described magnetic core is connected with groove matched in clearance.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 3, it is characterised in that described vertical animal gastrointestinal tract
Bionic digestion device also includes the first sealing ring being fixed on magnetic drive device with the junction of the silica gel plug with tube for transfusion.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 3, it is characterised in that described stirring rod is by connecting
Axle is connected with magnetic drive device, and the upper end of described connecting shaft is set in outside magnetic core, its bottom and the hollow top of stirring rod
Clamping.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 5, it is characterised in that described connecting shaft is silica gel
Pipe.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 1 or 2, it is characterised in that described magnetic drives fills
Put and include outer magnetic ring set, outer magnetic ring, isolation cover, internal magnetic ring and internal magnetic ring pitman；Described outer magnetic ring set with motor output shaft, on
Seal bootr is fixing to be connected；Described outer magnetic ring is nested and is located in outer magnetic ring；It is provided with isolation cover between described internal magnetic ring and outer magnetic ring；Institute
State internal magnetic ring to be arranged in isolation cover；One end of described internal magnetic ring pitman snaps in internal magnetic ring, and its other end is inserted through down
Seal bootr and silica gel plug, be connected with the top of stirring rod.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 1 or 2, it is characterised in that sheathed on described motor
Having motor cover, the bottom of described motor cover to be connected with motor fixing seat, described motor fixing seat is by upper seal bootr and lower seal bootr
Composition.
Vertical animal gastrointestinal tract Bionic digestion device the most as claimed in claim 1 or 2, it is characterised in that described vertical animal stomach
Intestinal Bionic digestion device also includes the pumping peristaltic pump being connected with input pipe and the pumping peristaltic pump being connected with outlet tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201620581819.6U CN205786549U (en) | 2016-06-16 | 2016-06-16 | A kind of vertical animal gastrointestinal tract Bionic digestion device |
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| CN201620581819.6U CN205786549U (en) | 2016-06-16 | 2016-06-16 | A kind of vertical animal gastrointestinal tract Bionic digestion device |
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| CN205786549U true CN205786549U (en) | 2016-12-07 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105974066A (en) * | 2016-06-16 | 2016-09-28 | 湖南中本智能科技发展有限公司 | Vertical type animal gastrointestinal tract bionic digestion device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105974066A (en) * | 2016-06-16 | 2016-09-28 | 湖南中本智能科技发展有限公司 | Vertical type animal gastrointestinal tract bionic digestion device |
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