CN105879114A - 用于整合入医疗装置的疏水性改善的药物 - Google Patents

用于整合入医疗装置的疏水性改善的药物 Download PDF

Info

Publication number
CN105879114A
CN105879114A CN201610206128.2A CN201610206128A CN105879114A CN 105879114 A CN105879114 A CN 105879114A CN 201610206128 A CN201610206128 A CN 201610206128A CN 105879114 A CN105879114 A CN 105879114A
Authority
CN
China
Prior art keywords
coating
polymer
drug
compound
stent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610206128.2A
Other languages
English (en)
Chinese (zh)
Inventor
N·P·德赛
陶春林
于成志
王庆伟
P·苏恩-施昂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abraxis Bioscience LLC
Original Assignee
American Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Bioscience Inc filed Critical American Bioscience Inc
Publication of CN105879114A publication Critical patent/CN105879114A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00Materials or methods for coatings medical devices
    • A61L2420/06Coatings containing a mixture of two or more compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201610206128.2A 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物 Pending CN105879114A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65417505P 2005-02-18 2005-02-18
US60/654,175 2005-02-18
CN2006800090730A CN101146514B (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2006800090730A Division CN101146514B (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物

Publications (1)

Publication Number Publication Date
CN105879114A true CN105879114A (zh) 2016-08-24

Family

ID=36917120

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201610206128.2A Pending CN105879114A (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN201310051405.3A Expired - Fee Related CN103143069B (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN2006800090730A Expired - Fee Related CN101146514B (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN201610206288.7A Pending CN105688289A (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN201410551109.4A Pending CN104667355A (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201310051405.3A Expired - Fee Related CN103143069B (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN2006800090730A Expired - Fee Related CN101146514B (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN201610206288.7A Pending CN105688289A (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物
CN201410551109.4A Pending CN104667355A (zh) 2005-02-18 2006-02-21 用于整合入医疗装置的疏水性改善的药物

Country Status (8)

Country Link
US (4) US20090130163A1 (https=)
EP (4) EP2896412A1 (https=)
JP (2) JP5139814B2 (https=)
CN (5) CN105879114A (https=)
AU (1) AU2006214100B2 (https=)
CA (1) CA2598213C (https=)
ES (1) ES2663495T3 (https=)
WO (1) WO2006089207A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0611954A2 (pt) 2005-06-10 2009-04-28 Univ Florida State Res Found processos para a produÇço de compostos de anel fundido policÍclico
CA2610898C (en) 2005-06-10 2013-01-22 Florida State University Research Foundation, Inc. Processes for the preparation of docetaxel
WO2007059118A1 (en) * 2005-11-14 2007-05-24 Abraxis Bioscience, Inc. Combretastatin derivatives and related therapeutic methods
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
WO2008109163A1 (en) * 2007-03-07 2008-09-12 Abraxis Bioscience, Llc. Nanoparticle comprising rapamycin and albumin as anticancer agent
US20100166869A1 (en) 2007-05-03 2010-07-01 Desai Neil P Methods and compositions for treating pulmonary hypertension
JP5579057B2 (ja) 2007-06-01 2014-08-27 アブラクシス バイオサイエンス, エルエルシー 再発性癌の処置のための方法および組成物
MX2010011165A (es) * 2008-04-10 2011-02-22 Abraxis Bioscience Llc Composiciones de derivados de taxano hidrofobos y sus usos.
JP2011517683A (ja) * 2008-04-10 2011-06-16 アブラクシス バイオサイエンス, エルエルシー 疎水性タキサン誘導体の組成物およびその使用
EP2416650B1 (en) * 2009-04-10 2020-02-26 Abraxis BioScience, LLC Nanoparticle formulations and uses therof
EP2447268A1 (en) 2010-10-29 2012-05-02 INDENA S.p.A. Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III
CN102649795B (zh) * 2011-06-23 2014-08-06 东北林业大学 10-甲氧基喜树碱衍生物、制备方法和用途
US9610385B2 (en) * 2013-03-07 2017-04-04 Abbott Cardiovascular Systems Inc. Method of fabricating an implantable medical device comprising a rapamycin derivative
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative
US10527604B1 (en) * 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
CN106242972B (zh) * 2016-07-29 2019-02-26 浙江大学 康普瑞汀药物前体、药物制剂和制备方法
CN106236752A (zh) * 2016-07-29 2016-12-21 浙江大学 联合用药抗肿瘤药物、制备方法及应用
IL277402B1 (en) 2018-03-20 2026-04-01 Abraxis Bioscience Llc Methods for treating central nervous system disorders using administration of MTOR inhibitor nanoparticles and albumin
CN112423737A (zh) 2018-05-22 2021-02-26 阿布拉科斯生物科学有限公司 用于治疗肺高压的方法和组合物
JP7832108B2 (ja) 2019-10-28 2026-03-17 アブラクシス バイオサイエンス, エルエルシー アルブミンおよびラパマイシンの医薬組成物
WO2022023414A2 (en) * 2020-07-29 2022-02-03 Biotronik Ag Pharmaceutical microsphere compositions and methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1418190A (zh) * 2000-03-17 2003-05-14 因德纳有限公司 N-脱乙酰基硫代秋水仙素衍生物及包含其的药物组合物
CN1543362A (zh) * 2002-05-09 2004-11-03 ����Ī�����ɷ����޹�˾ 用于预防再狭窄的血液相容性涂层的制剂、方法和应用
CN1568166A (zh) * 2001-10-15 2005-01-19 荷姆泰克股份有限公司 预防再狭窄的涂层支架

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141087A (en) * 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4208511A (en) 1977-01-19 1980-06-17 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4105034A (en) * 1977-06-10 1978-08-08 Ethicon, Inc. Poly(alkylene oxalate) absorbable coating for sutures
US4140678A (en) 1977-06-13 1979-02-20 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4205399A (en) 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4130639A (en) * 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
US4316885A (en) * 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5262423A (en) * 1992-10-29 1993-11-16 American Home Products Corporation Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
MX9307777A (es) * 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
US5468253A (en) 1993-01-21 1995-11-21 Ethicon, Inc. Elastomeric medical device
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5464929A (en) * 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5618552A (en) 1995-03-06 1997-04-08 Ethicon, Inc. Absorbable polyoxaesters
US5597579A (en) 1995-03-06 1997-01-28 Ethicon, Inc. Blends of absorbable polyoxaamides
US5607687A (en) 1995-03-06 1997-03-04 Ethicon, Inc. Polymer blends containing absorbable polyoxaesters
US5595751A (en) * 1995-03-06 1997-01-21 Ethicon, Inc. Absorbable polyoxaesters containing amines and/or amido groups
US5648088A (en) 1995-03-06 1997-07-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amide groups
US5700583A (en) 1995-03-06 1997-12-23 Ethicon, Inc. Hydrogels of absorbable polyoxaesters containing amines or amido groups
TW354293B (en) * 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
CZ288562B6 (cs) * 1995-09-12 2001-07-11 The Liposome Company, Inc. Taxanové deriváty, farmaceutický prostředek je obsahující a jejich použití
US6107332A (en) * 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US7445792B2 (en) * 2003-03-10 2008-11-04 Abbott Laboratories Medical device having a hydration inhibitor
US20030040790A1 (en) * 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US7455853B2 (en) * 1998-09-24 2008-11-25 Abbott Cardiovascular Systems Inc. Medical devices containing rapamycin analogs
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
DE60138683D1 (de) * 2000-01-25 2009-06-25 Edwards Lifesciences Corp Bioaktive beschichtungen zur vermeidung von gewebewachstum auf künstlichen herzklappen
JP2003525243A (ja) * 2000-02-28 2003-08-26 ザ ユニバーシティ オブ ブリティッシュ コロンビア 炎症性疾患の治療のための組成物及び方法
US6723373B1 (en) * 2000-06-16 2004-04-20 Cordis Corporation Device and process for coating stents
EP1647289A1 (en) * 2001-02-27 2006-04-19 Medtronic Vascular, Inc. Peroxisome proliferator-activated receptor gamma ligand eluting medical device
US20020127263A1 (en) * 2001-02-27 2002-09-12 Wenda Carlyle Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
GB0122393D0 (en) * 2001-09-17 2001-11-07 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility
EP1435939B1 (en) * 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
US20030065382A1 (en) * 2001-10-02 2003-04-03 Fischell Robert E. Means and method for the treatment of coronary artery obstructions
CA2470826A1 (en) * 2001-12-20 2003-07-03 Bristol-Myers Squibb Company Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability
JP2006507021A (ja) * 2002-03-18 2006-03-02 メドトロニック・エイヴイイー・インコーポレーテッド 再狭窄の危険のある解剖学的部位へ抗増殖性組成物を送付するための医療用具
AU2003234689A1 (en) * 2002-04-05 2003-10-27 Natural Pharmaceuticals, Inc. Selective acylation of secondary hydroxyl groups
AU2003241515A1 (en) * 2002-05-20 2003-12-12 Orbus Medical Technologies Inc. Drug eluting implantable medical device
EP2075014B9 (en) * 2002-05-24 2012-02-01 Angiotech International Ag Compositions and methods for coating medical implants
CN100363366C (zh) * 2002-06-27 2008-01-23 中国科学院上海药物研究所 一类喜树碱衍生物及制备方法
EP1516597A4 (en) * 2002-06-27 2010-11-10 Microport Medical Shanghai Co MEDICINES ELUTIONSSTENT
EP1523345A1 (en) * 2002-07-18 2005-04-20 Medtronic AVE Inc. Medical devices comprising a protein-tyrosine kinase inhibitor to inhibit restonosis
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
DE10244847A1 (de) * 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
EP1572242B1 (en) * 2002-12-13 2014-04-16 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040236415A1 (en) * 2003-01-02 2004-11-25 Richard Thomas Medical devices having drug releasing polymer reservoirs
US20040167572A1 (en) * 2003-02-20 2004-08-26 Roth Noah M. Coated medical devices
US20040236290A1 (en) * 2003-04-23 2004-11-25 Zimmermann Stephan A. Minimally invasive vascular apparatus modified to minimize scarring at introduction site
US20050033417A1 (en) * 2003-07-31 2005-02-10 John Borges Coating for controlled release of a therapeutic agent
CA2536192A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Soft tissue implants and anti-scarring agents
US7700612B2 (en) * 2003-12-23 2010-04-20 Abraxis Bioscience, Llc Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
ITMI20040164A1 (it) * 2004-02-03 2004-05-03 Indena Spa Derivati di n.deacetiltiocolchicina loro uso e formulazioni farmaceutiche che li contengono
EP1765426A4 (en) * 2004-05-12 2011-07-27 Medivas Llc WOUND HEALING POLYMER COMPOSITIONS AND METHOD FOR THEIR USE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1418190A (zh) * 2000-03-17 2003-05-14 因德纳有限公司 N-脱乙酰基硫代秋水仙素衍生物及包含其的药物组合物
CN1568166A (zh) * 2001-10-15 2005-01-19 荷姆泰克股份有限公司 预防再狭窄的涂层支架
CN1543362A (zh) * 2002-05-09 2004-11-03 ����Ī�����ɷ����޹�˾ 用于预防再狭窄的血液相容性涂层的制剂、方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GIUSEPPINA RASPAGLIO ET AL.: "Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors", 《BIOCHEMICAL PHARMACOLOGY》 *

Also Published As

Publication number Publication date
EP1861070B1 (en) 2018-01-17
CN101146514B (zh) 2013-03-27
CA2598213C (en) 2011-04-19
AU2006214100A2 (en) 2006-08-24
EP1861070A2 (en) 2007-12-05
JP5139814B2 (ja) 2013-02-06
CA2598213A1 (en) 2006-08-24
CN103143069A (zh) 2013-06-12
JP5566431B2 (ja) 2014-08-06
CN105688289A (zh) 2016-06-22
JP2008529745A (ja) 2008-08-07
CN104667355A (zh) 2015-06-03
CN101146514A (zh) 2008-03-19
US20090130163A1 (en) 2009-05-21
EP3345631A1 (en) 2018-07-11
JP2013034872A (ja) 2013-02-21
AU2006214100A1 (en) 2006-08-24
US20170203012A1 (en) 2017-07-20
US20150190556A1 (en) 2015-07-09
AU2006214100B2 (en) 2012-05-31
EP2896412A1 (en) 2015-07-22
ES2663495T3 (es) 2018-04-13
US20180318473A1 (en) 2018-11-08
CN103143069B (zh) 2016-05-04
EP3345632A1 (en) 2018-07-11
WO2006089207A3 (en) 2007-05-18
WO2006089207A2 (en) 2006-08-24

Similar Documents

Publication Publication Date Title
JP5566431B2 (ja) 医療装置に結合した改善された疎水性を有した薬剤
JP5271892B2 (ja) 医療デバイスを介した高親油性薬剤の送達
CN1589166B (zh) 包被有持续释放药物递送系统的支架及其使用方法
JP5271697B2 (ja) 医療装置を介する高親油性薬剤の送達
JP4796506B2 (ja) 医薬組成物
JP5385785B2 (ja) メラトニンとパクリタキセルとの組合せを備えた医療用ステント
JP2009530031A (ja) 医療デバイスを介した高親油性薬剤の送達
JP2006520217A (ja) 生物活性ステントおよびその使用方法
JP2008538302A (ja) Ii型糖尿病患者のための生理活性ステントおよびその使用方法
EP1933845A2 (en) Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore
JP2007532185A (ja) Ii型糖尿病のための生理活性ステントおよびその使用方法
JP2009505726A (ja) 生分解性ポリマーを含むことにより向上した官能性を有する医療機器及びコーティング
AU2012202903B2 (en) Drugs with improved hydrophobicity for incorporation in medical devices
AU2015201194B2 (en) Drugs with improved hydrophobicity for incorporation in medical devices
JP5297632B2 (ja) 血液凝固抑制材料並びにそれを用いたコーティング材料及び生体留置部材
JP2009077963A (ja) 生体内留置物
JP2008237677A (ja) 生体内留置物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160824

WD01 Invention patent application deemed withdrawn after publication