CN105878977A - Ginger and periostracum cicada composition and applications thereof - Google Patents

Ginger and periostracum cicada composition and applications thereof Download PDF

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Publication number
CN105878977A
CN105878977A CN201610161764.8A CN201610161764A CN105878977A CN 105878977 A CN105878977 A CN 105878977A CN 201610161764 A CN201610161764 A CN 201610161764A CN 105878977 A CN105878977 A CN 105878977A
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zingiberis recens
rhizoma zingiberis
cicadae
radix
compositions
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林新栋
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/904Stemonaceae (Stemona family), e.g. croomia
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
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Abstract

The invention relates to a ginger and periostracum cicada composition. The ginger and periostracum cicada composition is prepared from the following medicinal materials: fresh ginger, periostracum cicada, radix sophorae flavescentis, safflower carthamus, herba artemisia argyi, radix stemonae, radix arnebiae seu lithospermi, tubearculate speranskia herb, lucid ganoderma, the fruits of Chinese wolfberry, rhizoma ligustici wallichii, cortex phellodendri, herba artemisiae scopariae, fructus forsythiae, fructus cnidii and fructus arctii.

Description

A kind of Rhizoma Zingiberis Recens Cicadae compositions and application thereof
Technical field
The invention provides a kind of Rhizoma Zingiberis Recens Cicadae compositions and application thereof, belong to field of medicaments.
Background technology
Rhizoma Zingiberis Recens treatment is a kind of common external application physical therapy mode of present medical treatment, health preserving industry, is usually and Rhizoma Zingiberis Recens is polished into paste Shape or be fabricated to the products such as quintessence oil, directly Rhizoma Zingiberis Recens mud dressing on body skin, wraps with plastic fresh-keeping membrane, or Rhizoma Zingiberis Recens Quintessence oil processed drops in and spreads out massage on health, by the component content of Jiang Benshen: gingerol, zingiberol, oil of ginger terpene etc., accelerates health blood Liquid circulates, and dispels body and trembles with fear.Common Rhizoma Zingiberis Recens treats the character utilizing Rhizoma Zingiberis Recens relieving exterior syndrome and dispelling cold, can dispel " ailment said due to cold or exposure " and " damp ", nurses one's health human body Inner loop, treatment or relief of symptoms.
Common Rhizoma Zingiberis Recens is treated has simplicity, cheap, rapid-action, the feature of few side effects, but shortcoming is also apparent from: 1, can only dispel The raw symptom of the shallow table of human body, it is impossible to go deep into disease source;2, composition uniformity, the composition only with Jiang Benshen plays a role, reason Treatment scope is little, and the cold effect on moisture extraction of row is the most notable;3, quantity of perspiration is few, it is impossible to thoroughly get rid of cold-damp and heavy metal element;4, reality should Not there is in antiinflammation;5, effect unicity, can only get rid of cold-damp etc., it is impossible to supplement human body so nutrient;6、 Do not carry out the sterilization treatment that sterilizes, use safety without ensureing.
Summary of the invention
Rhizoma Zingiberis Recens known in the art treats effect can only dispel the raw of health shallow-layer, induces sweat and cannot go deep into internal disease source, And Rhizoma Zingiberis Recens Cicadae compositions of the present invention, repeatedly further investigate experiment by Lin Shi Rhizoma Zingiberis Recens Cicadae is steamed bone therapy, (preferably plateau is yellow to utilize Rhizoma Zingiberis Recens Rhizoma Zingiberis Recens), Cicadae with ten number taste specially good effect rare Chinese medicines combine, be possible not only to dispel health shallow-layer cold-damp heresy disease, it is often more important that Formula, through through nanotechnology treatments, utilizes the pungent element of plateau Dioscorea zingiberensis that pore is backed down, and medicine gas penetrates corium along pore Layer straight arrival sutura, the dampness in sutura, cold is steamed out formation perspiration and excretes, thus reaches dredge the meridian passage, lives Blood blood stasis dispelling, the effect of bactericidal antiphlogistic, thoroughly solve disease source.
It is that a people sleeps on the Rhizoma Zingiberis Recens of eight jin that Rhizoma Zingiberis Recens Cicadae steams the characteristic of bone therapy, and this formula make use of nanotechnology, passes through Rhizoma Zingiberis Recens Effect and the effect of Periostracum Cicadae are got through whole body meridian and epidermis, corium, capillary blood pore are opened medicine gas to penetrate skin corium along pore straight Arrive sutura, thoroughly internal wind, cold-damp, malicious and carcinogenic heavy metal, pull out from bone seam by the way of perspiring.
Relative to known Rhizoma Zingiberis Recens treatment technology, Rhizoma Zingiberis Recens Cicadae compositions of the present invention and corresponding Rhizoma Zingiberis Recens Cicadae steaming bone therapy feature:
1, by nanotechnology, the cold-damp of internal deep layer is thoroughly dispelled, through sutura and disease source;
2, diversity, utilizing the characteristic of Jiang Benshen to be combined with ten number taste rare Chinese medicines can full relief physical symptom;
What 3, Rhizoma Zingiberis Recens Cicadae steamed bone therapy row is the sweat that temperature is the lowest, it was demonstrated that row's is cold-damp, and whole during amount of sweat big, Effectively eliminate heavy metal of body material;
4, Rhizoma Zingiberis Recens Cicadae steam bone therapy can effectively antiinflammatory, antibacterial, removing toxic substances, reducing swelling and alleviating pain: as Flos Carthami in formula, Radix Sophorae Flavescentis antiinflammatory stop Blood, can effectively alleviate gynecological inflammation,
5, Rhizoma Zingiberis Recens Cicadae steams bone therapy scalable body immunity, warming the kidney to invigorate YANG, beauty and bright skin.
6, product is 300,000 grades through the clean cleanliness factor of sterilization process for producing environment, meets GB15979-- 2002 requirements.
Detailed Description Of The Invention
Present inventor is according to secret prescription handed down in the family from generation to generation, by validation trial, has summed up a secondary Rhizoma Zingiberis Recens Cicadae composite formula, It is external preparation, can by human body coated medicament or make human body lie on the bed of the medicine that tiled use, for fat Liver, hyperosteogeny, hyperlipidemia, hyperglycemia, all kinds of inflammation all have significant therapeutic effect.
One aspect of the application, it is provided that a kind of Rhizoma Zingiberis Recens Cicadae compositions, including Rhizoma Zingiberis Recens and Periostracum Cicadae.
Further aspect of the application, it is provided that a kind of Rhizoma Zingiberis Recens Cicadae compositions, including Rhizoma Zingiberis Recens, Periostracum Cicadae, Radix Sophorae Flavescentis, Flos Carthami, Folium Artemisiae Argyi, the Radix Stemonae, Radix Arnebiae (Radix Lithospermi), Herba speranskiae tuberculatae, Ganoderma, Fructus Lycii, Rhizoma Chuanxiong, Cortex Phellodendri, Herba Artemisiae Scopariae, Fructus Forsythiae, Fructus Cnidii, ZHONGBANGZI.
Further aspect of the application, it is provided that a kind of Rhizoma Zingiberis Recens Cicadae compositions, including Rhizoma Zingiberis Recens 3800g, Periostracum Cicadae 10g, hardship Ginseng 10g, Flos Carthami 10g, Folium Artemisiae Argyi 10g, Radix Stemonae 15g, Radix Arnebiae (Radix Lithospermi) 18g, Herba speranskiae tuberculatae 15g, Ganoderma 20g, Fructus Lycii 20g, Rhizoma Chuanxiong 20g, Cortex Phellodendri 20g, Herba Artemisiae Scopariae 30g, Fructus Forsythiae 15g, Fructus Cnidii 15g, ZHONGBANGZI 10g.
Further aspect of the application, it is provided that a kind of Rhizoma Zingiberis Recens Cicadae compositions, including Rhizoma Zingiberis Recens 3800g, Periostracum Cicadae 20g, hardship Ginseng 20g, Flos Carthami 20g, Folium Artemisiae Argyi 20g, Radix Stemonae 5g, Radix Arnebiae (Radix Lithospermi) 10g, Herba speranskiae tuberculatae 5g, Ganoderma 15g, Fructus Lycii 10g, Rhizoma Chuanxiong 10g, Cortex Phellodendri 10g, Herba Artemisiae Scopariae 5g, Fructus Forsythiae 20g, Fructus Cnidii 25g, ZHONGBANGZI 10g.
Further aspect of the application, it is provided that the preparation method of Rhizoma Zingiberis Recens Cicadae compositions, including: 1, Rhizoma Zingiberis Recens is weighed, pulverize To 1.8 ten thousand mesh (1000nm), standby;2, remaining medical material is weighed, be crushed to 1.8 ten thousand mesh (1000nm), place standby respectively;3、 1, the 2 standby materials of step are sufficiently mixed and stir, to obtain final product.
Further aspect of the application, can add or be added without proper amount of acetic acid hibitane in above-mentioned Rhizoma Zingiberis Recens Cicadae compositions And/or sodium benzoate.
In preparation method of the present invention, various medical materials produce if any juice in crushing process, then collect this juice and powder Medical material mixing for standby use after broken.
Further aspect of the application, it is provided that Rhizoma Zingiberis Recens Cicadae compositions preparation treatment fatty liver, hyperosteogeny, hyperlipidemia, Hyperglycemia, inflammation medicine in purposes.
In use, a kind of method is that human body lies flat on the bed or lies prone in bed to Rhizoma Zingiberis Recens Cicadae compositions of the present invention, Rhizoma Zingiberis Recens Cicadae compositions is spread upon human body surface equably, preferably spreads upon disease sites or surface, acupuncture point.Preferably, above-mentioned Rhizoma Zingiberis Recens Cicadae compositions is powder, pureed or pasty state.
In use, a kind of method is that Rhizoma Zingiberis Recens Cicadae compositions is placed on the plastics of sealing to Rhizoma Zingiberis Recens Cicadae compositions of the present invention In bag or in paper bag, the plastic bag or the paper bag that will be equipped with Rhizoma Zingiberis Recens Cicadae compositions tile in bed, then make patient lie low and are moulding On pocket or paper bag.See accompanying drawing 1.
Rhizoma Zingiberis Recens Cicadae compositions of the present invention can heat or do not heat before use.Preferably, Rhizoma Zingiberis Recens Cicadae compositions of the present invention exists Use front heating;It is highly preferred that Rhizoma Zingiberis Recens Cicadae compositions of the present invention is heated to 30-80 DEG C before use;It is highly preferred that Rhizoma Zingiberis Recens Cicadae of the present invention Compositions is heated to 40-70 DEG C before use;It is highly preferred that Rhizoma Zingiberis Recens Cicadae compositions of the present invention is heated to 45-60 DEG C before use.
Not fettered by content of the present invention, those skilled in the art can also be in herein described Rhizoma Zingiberis Recens Cicadae compositions On the basis of take the circumstances into consideration to add other Chinese crude drugs or compound, all in scope.
Accompanying drawing explanation
Fig. 1 is that Rhizoma Zingiberis Recens Cicadae steams bone therapy principle schematic.
Detailed description of the invention
Embodiment 1
Rhizoma Zingiberis Recens Cicadae composite formula: Rhizoma Zingiberis Recens 3800g, Periostracum Cicadae 10g, Radix Sophorae Flavescentis 10g, Flos Carthami 10g, Folium Artemisiae Argyi 10g, Radix Stemonae 15g, Radix Arnebiae (Radix Lithospermi) 18g, Herba speranskiae tuberculatae 15g, Ganoderma 20g, Fructus Lycii 20g, Rhizoma Chuanxiong 20g, Cortex Phellodendri 20g, Herba Artemisiae Scopariae 30g, Fructus Forsythiae 15g, Fructus Cnidii 15g, middle burdock Sub-10g.
Preparation method:
1, Rhizoma Zingiberis Recens is weighed, be crushed to 1.8 ten thousand mesh (1000nm), standby;
2, remaining medical material is weighed, be crushed to 1.8 ten thousand mesh (1000nm), place standby respectively;
3,1, the 2 standby materials of step are sufficiently mixed stir, to obtain final product.
Embodiment 2
Rhizoma Zingiberis Recens Cicadae composite formula: Rhizoma Zingiberis Recens 3800g, Periostracum Cicadae 20g, Radix Sophorae Flavescentis 20g, Flos Carthami 20g, Folium Artemisiae Argyi 20g, Radix Stemonae 5g, Radix Arnebiae (Radix Lithospermi) 10g, Herba speranskiae tuberculatae 5g, Ganoderma 15g, Fructus Lycii 10g, Rhizoma Chuanxiong 10g, Cortex Phellodendri 10g, Herba Artemisiae Scopariae 5g, Fructus Forsythiae 20g, Fructus Cnidii 25g, ZHONGBANGZI 10g。
Preparation method is with embodiment 1.
Pharmacodynamic experiment
Test example 1: hypoglycemic active testing
1. test material:
Animal: male Wistar rat, Nanjing animal center provides.
Reagent: embodiment 1, embodiment 2, comparative example 1-3.
Instrument: DV650 full automatic biochemical apparatus, SHIMAZU 1601 ultraviolet-uisible spectrophotometer, micropipettor, electronics Analytical balance, swirl mixing device.
Table 1. reagent contrasts
2. test method:
(1) prepared by diabetes animal model: 180-220g male Wistar rat 80, adaptability nursing three days, at random Select 10 rats as Normal group.Yu 70 rat limosis 12h rear left lumbar injection streptozotocin (STZ) 60mg/kg, All giving normal diet after injection, survey rat limosis tail vein sugar after 12h, blood glucose > 16.7mmol/L is that Glycemia Decline becomes Merit.Taking modeling winner 50 and only include test in, depilation processes, more than discard.
(2) animal packet and nursing: diabetes rat is randomly divided into 5 groups, blank group, embodiment 1 group, embodiment 2 groups, comparative example's 1-2 group, often group 10.Blank group refuses any process, embodiment 1,2 groups and comparative example 1, 2 groups carry out epidermis coating, ad lib and drinking-water with the medicine of 300g/ (kg d) respectively, do not use insulin.
(3) specimen sampling: after feeding 12 weeks, rat limosis 6h, weigh, 2% pentobarbital sodium intraperitoneal anesthesia, exoculation ball Take blood 5ml standby.Take above-mentioned rat from blood coagulation 2ml, utilize full automatic biochemical apparatus to measure blood glucose.
3. result of the test:
Serum blood glucose:
Table 2 is respectively organized the blood sugar detection result result of rat and is shown:
Visible, embodiment 1, embodiment 2 medicine have obvious effect of lowering blood sugar.And change the right of consumption or composition Than embodiment 1-2 group, not there is hypoglycemic activity or hypoglycemic activity is very poor.
Test example 2
Choose 15 patients between 30 to 70 years old and carry out quantum detection instrument inspection before and after the Rhizoma Zingiberis Recens Cicadae doing embodiment 1 steams bone therapy Surveying, Testing index is as follows:
Table 3
Table 4
Table 5
From the data of table 3-table 5, Rhizoma Zingiberis Recens Cicadae compositions of the present invention all has for fatty liver, hyperglycemia, hyperlipidemia, inflammation Have significant therapeutic effect.

Claims (7)

1. a Rhizoma Zingiberis Recens Cicadae compositions, including Rhizoma Zingiberis Recens and Periostracum Cicadae.
2. a Rhizoma Zingiberis Recens Cicadae compositions, including Rhizoma Zingiberis Recens, Periostracum Cicadae, Radix Sophorae Flavescentis, Flos Carthami, Folium Artemisiae Argyi, the Radix Stemonae, Radix Arnebiae (Radix Lithospermi), Herba speranskiae tuberculatae, Ganoderma, Fructus Lycii, Rhizoma Chuanxiong, Cortex Phellodendri, Herba Artemisiae Scopariae, Fructus Forsythiae, Fructus Cnidii, ZHONGBANGZI.
3. a kind of Rhizoma Zingiberis Recens Cicadae compositions as claimed in claim 2, including Rhizoma Zingiberis Recens 3800g, Periostracum Cicadae 10g, Radix Sophorae Flavescentis 10g, Flos Carthami 10g, Folium Artemisiae Argyi 10g, Radix Stemonae 15g, Radix Arnebiae (Radix Lithospermi) 18g, Herba speranskiae tuberculatae 15g, Ganoderma 20g, Fructus Lycii 20g, Rhizoma Chuanxiong 20g, Cortex Phellodendri 20g, Herba Artemisiae Scopariae 30g, Fructus Forsythiae 15g, Fructus Cnidii 15g, ZHONGBANGZI 10g.
4. a kind of Rhizoma Zingiberis Recens Cicadae compositions as claimed in claim 2, including Rhizoma Zingiberis Recens 3800g, Periostracum Cicadae 20g, Radix Sophorae Flavescentis 20g, Flos Carthami 20g, Folium Artemisiae Argyi 20g, Radix Stemonae 5g, Radix Arnebiae (Radix Lithospermi) 10g, Herba speranskiae tuberculatae 5g, Ganoderma 15g, Fructus Lycii 10g, Rhizoma Chuanxiong 10g, Cortex Phellodendri 10g, Herba Artemisiae Scopariae 5g, company Stick up 20g, Fructus Cnidii 25g, ZHONGBANGZI 10g.
5. the Rhizoma Zingiberis Recens Cicadae compositions as described in any one of claim 1-4, wherein can add or be added without proper amount of acetic acid chlorine Determine and/or sodium benzoate.
6. the preparation method of Rhizoma Zingiberis Recens Cicadae compositions described in any one of claim 1-5, including: Rhizoma Zingiberis Recens is weighed, is crushed to 1.8 ten thousand mesh (1000nm), standby;Remaining medical material is weighed, is crushed to 1.8 ten thousand mesh (1000nm), places standby respectively;Above-mentioned steps is standby It is sufficiently mixed with material and stirs, to obtain final product.
7. as described in any one of claim 1-5, Rhizoma Zingiberis Recens Cicadae compositions treats fatty liver, hyperosteogeny, hyperlipidemia, high blood in preparation Sugar, inflammation medicine in purposes.
CN201610161764.8A 2016-03-21 2016-03-21 Ginger and periostracum cicada composition and applications thereof Pending CN105878977A (en)

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Application publication date: 20160824