CN105878574A - 一种治疗肾虚的中药组合物及其制备方法 - Google Patents
一种治疗肾虚的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN105878574A CN105878574A CN201610461255.7A CN201610461255A CN105878574A CN 105878574 A CN105878574 A CN 105878574A CN 201610461255 A CN201610461255 A CN 201610461255A CN 105878574 A CN105878574 A CN 105878574A
- Authority
- CN
- China
- Prior art keywords
- fructus
- chinese medicine
- semen
- medicine composition
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 210000003734 kidney Anatomy 0.000 title claims abstract description 53
- 230000007812 deficiency Effects 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 210000000582 semen Anatomy 0.000 claims abstract description 64
- 241000208340 Araliaceae Species 0.000 claims abstract description 20
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 19
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 19
- 235000008434 ginseng Nutrition 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000002775 capsule Substances 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- -1 be dried Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 150000001875 compounds Chemical class 0.000 abstract description 9
- 238000010792 warming Methods 0.000 abstract description 4
- 235000000661 Rosa laevigata Nutrition 0.000 abstract description 2
- 241001278833 Rosa laevigata Species 0.000 abstract description 2
- 241000270708 Testudinidae Species 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 230000027939 micturition Effects 0.000 description 17
- 208000024891 symptom Diseases 0.000 description 17
- 239000008280 blood Substances 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 7
- 208000009205 Tinnitus Diseases 0.000 description 7
- 208000002173 dizziness Diseases 0.000 description 7
- 206010022437 insomnia Diseases 0.000 description 7
- 210000003127 knee Anatomy 0.000 description 7
- 201000001881 impotence Diseases 0.000 description 6
- 231100000886 tinnitus Toxicity 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000021267 infertility disease Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 208000008967 Enuresis Diseases 0.000 description 4
- 206010059013 Nocturnal emission Diseases 0.000 description 4
- 206010041497 Spermatorrhoea Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 208000000509 infertility Diseases 0.000 description 4
- 230000036512 infertility Effects 0.000 description 4
- 206010036596 premature ejaculation Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 206010021118 Hypotonia Diseases 0.000 description 3
- 208000007466 Male Infertility Diseases 0.000 description 3
- 206010054949 Metaplasia Diseases 0.000 description 3
- 206010047513 Vision blurred Diseases 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 230000035558 fertility Effects 0.000 description 3
- 208000017561 flaccidity Diseases 0.000 description 3
- 230000015689 metaplastic ossification Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 241000283026 Cervus elaphus Species 0.000 description 2
- 206010011878 Deafness Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 235000002710 Ilex cornuta Nutrition 0.000 description 2
- 241001310146 Ilex cornuta Species 0.000 description 2
- 206010021929 Infertility male Diseases 0.000 description 2
- 206010024419 Libido decreased Diseases 0.000 description 2
- 208000019914 Mental Fatigue Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 240000006079 Schisandra chinensis Species 0.000 description 2
- 206010046788 Uterine haemorrhage Diseases 0.000 description 2
- 206010063146 Uterine hypoplasia Diseases 0.000 description 2
- 208000031975 Yang Deficiency Diseases 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 231100000535 infertility Toxicity 0.000 description 2
- 210000004914 menses Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000036299 sexual function Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000004304 visual acuity Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241000282985 Cervus Species 0.000 description 1
- 241000283007 Cervus nippon Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000207901 Cuscuta Species 0.000 description 1
- 244000013539 Cuscuta australis Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 241000961970 Plantago depressa Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 241001092459 Rubus Species 0.000 description 1
- 235000008422 Schisandra chinensis Nutrition 0.000 description 1
- 241000736078 Schisandra sphenanthera Species 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000037114 Symptom Flare Up Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 206010003883 azoospermia Diseases 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 208000008634 oligospermia Diseases 0.000 description 1
- 230000036616 oligospermia Effects 0.000 description 1
- 231100000528 oligospermia Toxicity 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 206010036601 premature menopause Diseases 0.000 description 1
- 208000017942 premature ovarian failure 1 Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供了一种治疗肾虚的中药组合物及其制备方法。该中药组合物是以鹿茸、龟甲、枸杞子、菟丝子、人参、金樱子、沙苑子、覆盆子、车前子和五味子为中药原料进行提取,然后添加适量的辅料制成的合适中药复方制剂。该中药组合物专于温补肾阳,组方科学、合理,属于治疗肾虚的特效方,疗效显著。
Description
技术领域
本发明涉及中药技术领域,具体的说,涉及一种以天然中药鹿茸、龟甲、菟丝子、枸杞子等为主药原料制成的治疗肾虚的纯中药组合物及其制备方法。
背景技术
肾虚是指肾脏精气阴阳不足,分肾阴虚和肾阳虚。肾虚的症状在性功能方面表现为性功能降低:男子性兴趣降低,性欲降低,阳萎或阳物举而不坚,遗精、滑精、早泄,显微镜检查可见精子减少或精子活动力减低,不育;女子子宫发育不良,如幼稚子宫、卵巢早衰闭经、月经不调,性欲减退,不孕等。
随着社会的发展,不孕不育的发生率越来越高,据统计目前全球不孕不育发生率为15%左右。由于男性因素引起的不育称为男性不育症。研究证实男性不育主要与精子运动能力有关。精子功能异常时出现的“精子活力低下症”所引起的男性不育大致相当于中医的“精弱”、“精冷”、“精寒”等证。《金匮要略》云:“男子脉浮弱而涩为无子精气冷”,《诸病源后论》云“丈夫无子者,其精清如水,冷如冰铁,皆为无子之候”,《石室秘录》云:“男子不生子,有六因,一精寒也,一气衰也……”,朱丹溪《丹溪心法》有谓“有精虚精弱不能成胎者”。精寒、精冷则精失温煦,无阳则不动,致精子无活力,或者活动度减低,从而导致受孕困难。
气血化生于脾胃,精血化生于肝肾,人体只有气血不亏,精血无损,精神才能充沛。肾为先天之本,水火之脏,元气所聚。肾阳不足,命门火衰,不能温煦,甚则火不生土,影响脾胃的受纳与运化,故气衰神疲、腰膝酸软,或饮食减少;肾藏精,阳虚火衰,封藏失职,精关不固,或肾虚不能固摄,故阳痿遗精、久不孕育。《景岳全书·新方八阵》说“善补阳者,必于阴中求阳,则阳得阴助,而生化无穷。”肾主骨生髓,髓生血,肾气盛则髓充骨健,血得生源。故治宜温肾助阳,固肾益精,益气养血,阴阳并补。
根据我国传统中医理论,针对肾虚的发病机理,通过将补肾固精、养肝健脾的中药进行合理的配伍,以达到改善和治疗肾虚症状的目的。
发明内容
为了克服现有技术中的技术问题,本发明提供了一种以鹿茸、龟甲、菟丝子、枸杞子等为主药的治疗肾虚的中药组合物。本发明的中药组合物具有温肾助阳、填精止遗的功效,用于治疗肾虚精亏所致的阳痿不育、遗精早泄、腰膝酸软、神疲乏力、怯寒畏冷、须发早白,尿频而清等症。
为达到上述技术效果,本发明是通过以下的技术方案来实施的。
在本发明的第一方面,提供了一种治疗肾虚的中药组合物,是由如下中药制备而成:鹿茸、龟甲、枸杞子、菟丝子、人参、金樱子、沙苑子、覆盆子、车前子和五味子。
本发明中药组合物中的各味中药均为天然药材。方中的鹿茸为鹿科动物梅花鹿(Cervus nip port Temminck)或马鹿(Cervus elaphus Linnaeus)的雄鹿未骨化密生鸾毛的幼角。鹿茸性甘、咸,温。归肾、肝经。具有壮肾阳,益精血,强筋骨,调冲任,托疮毒。用于肾阳不足,精血亏虚,阳痿滑精,宫冷不孕,羸瘦,神疲,畏寒,眩晕,耳鸣,耳聋,腰脊冷痛,筋骨痿软,崩漏带下,阴疽不敛。龟甲为龟科动物乌龟的腹甲,具有滋阴潜阳,补肾填精的功效,主治肾阴亏损,骨蒸潮热,盗汗;热病伤阴,阴虚风动;腰腿酸软,筋骨痿弱;小儿卤门不和;以及崩漏等痛症。枸杞子为茄科植物枸杞的成熟果实,具有补肾益精,养肝明目,补血安神,生津止渴,润肺止咳的功效,主治肝肾阴亏,腰膝酸软,头晕,目眩,目昏多泪,虚劳咳嗽,消渴,遗精。菟丝子为旋花科植物南方菟丝子Cuscuta australis R.Br.或菟丝子Cuscutachinensis Lam.的干燥成熟种子。具有补益肝肾,固精缩尿,安胎,明目,止泻之功效,常用于治疗肝肾不足,腰膝酸软,阳痿遗精,遗尿尿频,肾虚胎漏,胎动不安,目昏耳鸣,脾肾虚泻。人参为五加科植物人参的根,具有大补元气,固脱生津,安神的功效,主治劳伤虚损,食少,倦怠,反胃吐食,大便滑-泄,虚咳喘促,自汗暴脱,惊悸,健忘,眩晕头痛,阳-痿,尿频,消渴,妇女崩漏,小儿慢惊,及久虚不复,一切气血津液不足之证。金樱子为蔷薇科植物金樱子Rosa laevigata Michx.的干燥成熟果实。具有固精缩尿,固崩止带,涩肠止泻之功效。常用于治疗遗精滑精,遗尿尿频,崩漏带下,久泻久痢。沙苑子为豆科植物扁茎黄芪Astragaluscomplanatus R.Brown.的干燥成熟种子。具有温补肝肾,固精,缩尿,明目的功效,主治肾虚腰痛,遗精早泄,白浊带下,小便余沥,眩晕目昏。覆盆子为蔷薇科植物华东覆盆子Rubuschingii Hu的干燥果实。具有益肾固精缩尿,养肝明目之功效。常用于治疗遗精滑精,遗尿尿频,阳痿早泄,目暗昏花。车前子为车前科植物车前或平车前的干燥成熟种子。具有利水通淋、渗湿止泻、清肝明目、清热化痰的功效,主治小便不利;淋浊带下;水肿胀满;暑湿泻痢;目赤障翳;痰热咳喘。五味子为木兰科植物五味子Schisandra chinensis (Turcz.)Baill.或华中五味子Schisandra sphenanthera Rehd. et Wils.的干燥成熟果实。具有收敛固涩,益气生津,补肾宁心的功效。用于治疗久嗽虚喘,梦遗滑精,遗尿尿频,久泻不止,自汗,盗汗,津伤口渴,短气脉虚,内热消渴,心悸失眠。
对于本发明的中药组合物,鹿茸、龟甲、枸杞子、菟丝子、人参、金樱子、沙苑子、覆盆子、车前子和五味子的重量比为1-9∶4-15∶6-20∶6-20∶1-8∶5-18∶4-18∶3-10∶3-9∶2-7;更优选为2-8∶3-12∶8-12∶8-12∶1-5∶8-12∶6-10∶4-6∶4-6∶2-5,最优选为2∶9∶10∶10∶3∶10∶8∶5∶5∶3。
本申请人发现,分别将鹿茸、龟甲、人参干燥粉碎成细粉,并将菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子用水煎煮提取,能获得最优化的治疗效果。因此,在本发明的中药组合物中,包含菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子的水提取物。优选地,水提取物是用水煎煮提取得到,优选用水煎煮提取2次。更优选的,菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4-8 倍量水煎煮两次,第一次 2-3 小时,第二次 1-2 小时。
另一方面,本发明的中药组合物可采用任选的药学上可接受的辅料和常规方法制备得到药学上常见的剂型,例如胶囊剂、颗粒剂、口服液、片剂、丸剂、微丸、汤剂、散剂等口服固体制剂。但是,优选的中药制剂及其制备方法如下。
在一种实施方式中,本发明中药制剂的制备方法包括如下步骤:
⑴将鹿茸、龟甲、人参干燥粉碎成细粉;
⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4-8 倍量水煎煮两次,第一次 2-3 小时,第二次 1-2 小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.20-1.30;浓缩液离心、除杂,滤液浓缩后干燥,粉碎成细粉;
⑶将步骤⑵制得的细粉加入到步骤⑴制得的细粉中,并添加适量的淀粉、微晶纤维素,混合均匀,分装入胶囊中,即得胶囊剂。
在另一种实施方式中,本发明中药制剂的制备方法包括如下步骤:
⑴将鹿茸、龟甲、人参干燥粉碎成细粉;
⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4-8 倍量水煎煮两次,第一次 2-3 小时,第二次 1-2 小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.20-1.30;
⑶将浓缩液喷雾在步骤⑴所制得的细粉上,加入适量蔗糖,干燥,制软材,制粒,干燥,整粒,分装,即得颗粒剂。
申请人发现,用上述方法制备得到的中药制剂不仅起效快,并且便于携带、质量稳定、疗效显著。
另一方面,本发明提供了所述中药组合物或中药制剂在制备治疗肾虚的药品中的应用。
本发明在传统补肾阳处方的研究基础上,用鹿茸增强补阳作用;龟甲滋阴潜阳,取“阴中求阳”,与枸杞子、菟丝子共为君药,加强填精止遗之功。此外,增加人参益气生津,以加强化生气血之源;金樱子固精缩尿,沙苑子补肾固精,与覆盆子共为臣药,助君药补阳之功,使全方药效更能专于温补肾阳。
本发明组合物中所采用的中药均为已知的天然中药原料,其组方科学、合理,属于治疗肾虚的特效方,疗效显著,总有效率达到96%,且在治疗过程中未发现任何毒副作用。另外,本发明的组合物配制方法简单、成本低、来源丰富,适应工业化生产的需求。
具体实施方式
以下通过实施例的形式来进一步说明本发明的一种治疗肾虚的中药组合物及制备方法,但不应将此理解为本发明的限制。凡属本发明上述内容所实现的技术均属于本发明的范畴。
实施例1:
中药配方:鹿茸2g、龟甲9g、枸杞子10g、 菟丝子10g、人参3g、金樱子10g、沙苑子8g、覆盆子5g、车前子5g、五味子3g。
制备方法:将鹿茸、龟甲、人参干燥粉碎成细粉;⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 6倍量水煎煮两次,第一次 2 小时,第二次 2 小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.25;浓缩液离心、除杂,滤液浓缩后干燥,粉碎成细粉;⑶将步骤⑵制得的细粉加入到步骤⑴制得的细粉中,并添加适量的淀粉、微晶纤维素,混合均匀,分装入胶囊中,即得胶囊剂。
实施例2:
中药配方:鹿茸8g、龟甲10g、枸杞子8g、 菟丝子8g、人参2g、金樱子12g、沙苑子8g、覆盆子4g、车前子4g、五味子5g。
制备方法:将鹿茸、龟甲、人参干燥粉碎成细粉;⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加5倍量水煎煮两次,第一次 3小时,第二次1小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.26;浓缩液离心、除杂,滤液浓缩后干燥,粉碎成细粉;⑶将步骤⑵制得的细粉加入到步骤⑴制得的细粉中,并添加适量的淀粉、微晶纤维素,混合均匀,分装入胶囊中,即得胶囊剂。
实施例3:
中药配方:鹿茸5g、龟甲12g、枸杞子10g、 菟丝子10g、人参2g、金樱子8g、沙苑子8g、覆盆子5g、车前子5g、五味子2g。
制备方法:⑴将鹿茸、龟甲、人参干燥粉碎成细粉;⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4 倍量水煎煮两次,第一次 3 小时,第二次 2 小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.28;⑶将浓缩液喷雾在步骤⑴所制得的细粉上,加入适量蔗糖,干燥,制软材,制粒,干燥,整粒,分装,即得颗粒剂。
实施例4:临床试验数据
一、患者基本情况:
从医院就诊病人中挑选了共186例进行临床观察,其中年龄范围是28~63岁,平均年龄39.4岁,男性105例,女性81例,病程为3个月~16年。
二、诊断依据
通过以下指标来作为肾虚的诊断依据:-腰膝酸软或足跟痛;-脱发或牙齿松动;-耳鸣或耳聋;-尿不尽或尿失禁;-性功能减退、不孕或不育。186例患者的诊断分布情况见表1,其中部分患者同时表现出多种肾虚症状。
表1、186例患者的诊断分布情况
三、治疗方法
将186例患者随机分成三组,每组62人,第一组服用本申请实施例1制备的胶囊剂,第二组服用本申请实施例2制备的胶囊剂,第三组服用本申请实施例3制备的颗粒剂。一天三次,4周为一个疗程,共治疗两个疗程。治疗期间忌生冷辛辣刺激性食物。
四、疗效标准
-痊愈:症状完全消失,停药3个月后无反复;
-显效:症状明显得到缓解;
-有效:症状有所减轻,但偶尔会加重;
-无效:症状无缓解或有加重趋势。
五、治疗结果
三组患者经两个疗程治疗后的结果见表2。
表2、三组患者的治疗结果
组别 | 治愈 | 显效 | 有效 | 无效 | 治愈率 | 总有效率 |
第1组 | 39 | 13 | 8 | 2 | 62.9% | 96.8% |
第2组 | 36 | 12 | 10 | 4 | 58.1% | 93.5% |
第3组 | 37 | 15 | 7 | 3 | 59.7% | 95.2% |
由上表可以看出,用本申请实施例1-3制备得到的中药复方制剂对肾虚患者进行两个疗程的治疗后,总有效率达到了93%以上,最高为96.8%,并且治愈率也达到了58%以上,表明本申请的中药复方制剂能有效治疗肾虚引起的各种症状。
实施例5:典型病例
病例1:王某,女,42岁。患者主诉近三个月内头昏脑胀、腰膝酸软、手脚无力,伴有经常性失眠。经诊断为肾虚。服用本发明实施例1的中药复方制剂一个疗程后,症状明显得到改善;继续服用两个疗程后,所有症状均消失。两个月后随访,未出现症状反复现象。
病例2:田某,男,38岁。患者主诉一年内经常性耳鸣、尿频、尿急、性欲减退。经诊断为肾虚。服用本发明实施例1的中药复方制剂一个疗程后,耳鸣和尿急症状明显得到改善;继续服用两个疗程后,排尿次数基本上正常,夫妻生活次数增加。
病例3:周某,男,51岁。患者主诉半年内经常失眠、腰酸背痛、头晕无力、尿频、失眠多梦。经诊断为肾虚。服用本发明实施例3的中药复方制剂一个疗程后,症状明显减轻;继续服用两个疗程后,所有症状均消失。两个月后随访,未出现症状反复现象。
病例4:杜某,女,32岁。患者主诉经常失眠、小便无力、四肢发胀、结婚5年未怀孕。经诊断为肾虚。服用本发明实施例1的中药复方制剂一个疗程后,失眠症状明显减轻;继续服用两个疗程后,其余症状基本消失,精神状态明显好转。
病例5:桑某,男,58岁。患者主诉多年有耳鸣、腰膝酸软、尿频、小便无力、失眠多梦等症状。经诊断为肾虚。服用本发明实施例1的中药复方制剂一个疗程后,耳鸣和失眠症状有所缓解;继续服用两个疗程后,所有症状均有明显改善。
Claims (10)
1.一种治疗肾虚的中药组合物,其特征在于由如下中药制备而成:鹿茸、龟甲、枸杞子、菟丝子、人参、金樱子、沙苑子、覆盆子、车前子和五味子。
2.如权利要求1所述的中药组合物,其特征在于鹿茸、龟甲、枸杞子、菟丝子、人参、金樱子、沙苑子、覆盆子、车前子和五味子的重量比为1-9∶4-15∶6-20∶6-20∶1-8∶5-18∶4-18∶3-10∶3-9∶2-7;更优选为2-8∶3-12∶8-12∶8-12∶1-5∶8-12∶6-10∶4-6∶4-6∶2-5,最优选为2∶9∶10∶10∶3∶10∶8∶5∶5∶3。
3.如权利要求1或2所述的中药组合物,其特征在于包含菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子的水提取物。
4.如权利要求3所述的中药组合物,其特征在于所述的水提取物是用水煎煮提取得到,优选用水煎煮提取2次。
5.如权利要求4所述的中药组合物,其特征在于菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4-8 倍量水煎煮两次,第一次 2-3 小时,第二次 1-2 小时。
6.一种用于治疗肾虚的中药制剂,其特征在于包括权利要求1-5任一所述的中药组合物和任选的药学上可接受的辅料。
7.如权利要求6所述的中药制剂,其特征在于是胶囊剂、颗粒剂、口服液、片剂、丸剂、微丸、汤剂、散剂等口服固体制剂。
8.一种如权利要求6或7所述的中药制剂的制备方法,其特征在于包括如下步骤:
⑴将鹿茸、龟甲、人参干燥粉碎成细粉;
⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4-8 倍量水煎煮两次,第一次 2-3 小时,第二次 1-2 小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.20-1.30;浓缩液离心、除杂,滤液浓缩后干燥,粉碎成细粉;
⑶将步骤⑵制得的细粉加入到步骤⑴制得的细粉中,并添加适量的淀粉、微晶纤维素,混合均匀,分装入胶囊中,即得胶囊剂。
9.一种如权利要求6或7所述的中药制剂的制备方法,其特征在于包括如下步骤:
⑴将鹿茸、龟甲、人参干燥粉碎成细粉;
⑵菟丝子、枸杞子、金樱子、沙苑子、覆盆子、车前子、五味子加 4-8 倍量水煎煮两次,第一次 2-3 小时,第二次 1-2 小时;将两次提取液过滤,合并滤液,并浓缩相对密度至1.20-1.30;
⑶将浓缩液喷雾在步骤⑴所制得的细粉上,加入适量蔗糖,干燥,制软材,制粒,干燥,整粒,分装,即得颗粒剂。
10.如权利要求1-5任一所述的中药组合物或权利要求6或7所述的中药制剂在制备治疗肾虚的药品中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610461255.7A CN105878574B (zh) | 2016-06-23 | 2016-06-23 | 一种治疗肾虚的中药组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610461255.7A CN105878574B (zh) | 2016-06-23 | 2016-06-23 | 一种治疗肾虚的中药组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105878574A true CN105878574A (zh) | 2016-08-24 |
CN105878574B CN105878574B (zh) | 2017-06-16 |
Family
ID=56718789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610461255.7A Active CN105878574B (zh) | 2016-06-23 | 2016-06-23 | 一种治疗肾虚的中药组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105878574B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106309727A (zh) * | 2016-09-19 | 2017-01-11 | 北京大学第医院 | 一种防治肾虚血瘀型2型糖尿病认知功能障碍的中药组合物 |
CN106377622A (zh) * | 2016-11-30 | 2017-02-08 | 南京市中医院 | 一种治疗早期糖尿病肾病的中药及其制备方法 |
CN116870102A (zh) * | 2023-07-27 | 2023-10-13 | 北京力晟鸿吉信息科技发展有限公司 | 一种降血糖中药组合物及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1236043A (zh) * | 1998-05-14 | 1999-11-24 | 范应华 | 点连接式玻璃幕墙中的调整系统 |
CN100421699C (zh) * | 2005-03-03 | 2008-10-01 | 遵义廖元和堂药业有限公司 | 一种治疗男性不育生精复方中药制剂 |
-
2016
- 2016-06-23 CN CN201610461255.7A patent/CN105878574B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1236043A (zh) * | 1998-05-14 | 1999-11-24 | 范应华 | 点连接式玻璃幕墙中的调整系统 |
CN100421699C (zh) * | 2005-03-03 | 2008-10-01 | 遵义廖元和堂药业有限公司 | 一种治疗男性不育生精复方中药制剂 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106309727A (zh) * | 2016-09-19 | 2017-01-11 | 北京大学第医院 | 一种防治肾虚血瘀型2型糖尿病认知功能障碍的中药组合物 |
CN106309727B (zh) * | 2016-09-19 | 2019-07-19 | 北京大学第一医院 | 一种防治肾虚血瘀型2型糖尿病认知功能障碍的中药组合物 |
CN106377622A (zh) * | 2016-11-30 | 2017-02-08 | 南京市中医院 | 一种治疗早期糖尿病肾病的中药及其制备方法 |
CN116870102A (zh) * | 2023-07-27 | 2023-10-13 | 北京力晟鸿吉信息科技发展有限公司 | 一种降血糖中药组合物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
CN105878574B (zh) | 2017-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102342992B (zh) | 一种用于治疗失眠的中药组合物及其制剂的制备方法 | |
CN103977358A (zh) | 一种降脂护肝的口服中药 | |
CN104983818A (zh) | 一种治疗妇科疾病的中药及其制备方法 | |
CN103550695A (zh) | 一种治疗乳腺癌的药物 | |
CN102579708B (zh) | 一种壮阳补肾健肝肺的中药 | |
CN101810763B (zh) | 治疗男性不育和性功能障碍的中药制剂及其制备方法 | |
CN105878574B (zh) | 一种治疗肾虚的中药组合物及其制备方法 | |
CN104069474A (zh) | 一种治疗脂溢性脱发的中药组合物及其制备方法 | |
CN104673597A (zh) | 一种多功能养生酒及其制作方法 | |
CN102266532A (zh) | 一种治疗脂肪肝的药物及其制备方法 | |
CN103977306A (zh) | 一种治疗乙型肝炎的药物及其制备方法 | |
CN105031588A (zh) | 一种治疗鼻炎的中药及其制备方法 | |
CN104147156B (zh) | 一种含有补肾中药组合物的饮料及其制备方法 | |
CN102058723A (zh) | 治疗阳痿、早泄和性功能障碍的中药及其制备方法 | |
CN102293941B (zh) | 一种治疗糖尿病的中药组合物 | |
CN104225569A (zh) | 一种治疗慢性肠炎的中药组合物 | |
CN103961658A (zh) | 一种降脂护肝的胶囊制剂 | |
CN103251821A (zh) | 一种治疗风热头痛和偏头痛的药物及其制备方法 | |
CN104257813B (zh) | 一种调理气血的中药组合物及其制备方法 | |
CN102988883B (zh) | 一种治疗肝炎的药物及其制备方法 | |
CN103656451B (zh) | 一种治疗湿热的药物及其制备方法 | |
CN108042744A (zh) | 一种用于治疗前列腺疾病的中药组合物及制备方法 | |
CN102218107A (zh) | 一种治疗失眠症的中药组合物 | |
CN104784587A (zh) | 一种治疗内分泌失调型不孕的中药组合物及其制备方法 | |
CN105412706A (zh) | 一种治疗女性内分泌失调的中药组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant |