CN105878531A - Matching agent for treating paronychia - Google Patents
Matching agent for treating paronychia Download PDFInfo
- Publication number
- CN105878531A CN105878531A CN201610368355.5A CN201610368355A CN105878531A CN 105878531 A CN105878531 A CN 105878531A CN 201610368355 A CN201610368355 A CN 201610368355A CN 105878531 A CN105878531 A CN 105878531A
- Authority
- CN
- China
- Prior art keywords
- parts
- fermentation
- matching
- medicament
- paronychial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010034016 Paronychia Diseases 0.000 title abstract description 9
- 241000029132 Paronychia Species 0.000 title abstract description 8
- 238000000855 fermentation Methods 0.000 claims abstract description 84
- 230000004151 fermentation Effects 0.000 claims abstract description 72
- 230000001954 sterilising effect Effects 0.000 claims abstract description 39
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 38
- 239000006071 cream Substances 0.000 claims abstract description 32
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 58
- 239000007788 liquid Substances 0.000 claims description 56
- 238000002360 preparation method Methods 0.000 claims description 42
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 35
- 239000000661 sodium alginate Substances 0.000 claims description 35
- 235000010413 sodium alginate Nutrition 0.000 claims description 35
- 229940005550 sodium alginate Drugs 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000284 extract Substances 0.000 claims description 32
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- 238000010992 reflux Methods 0.000 claims description 20
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 19
- 238000000605 extraction Methods 0.000 claims description 18
- 241001489978 Eupolyphaga Species 0.000 claims description 14
- 239000000469 ethanolic extract Substances 0.000 claims description 14
- 239000011593 sulfur Substances 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 244000020191 Salix babylonica Species 0.000 claims description 12
- 235000002493 Salix babylonica Nutrition 0.000 claims description 12
- 235000013312 flour Nutrition 0.000 claims description 12
- 239000002054 inoculum Substances 0.000 claims description 12
- 239000010985 leather Substances 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims description 11
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 claims description 11
- 235000010081 allicin Nutrition 0.000 claims description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 6
- 235000007164 Oryza sativa Nutrition 0.000 claims description 6
- 235000013527 bean curd Nutrition 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 6
- 235000013360 fish flour Nutrition 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 6
- 235000009566 rice Nutrition 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- 241000186000 Bifidobacterium Species 0.000 claims description 2
- 206010048245 Yellow skin Diseases 0.000 claims description 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000271039 Agkistrodon Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 241000195474 Sargassum Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000020995 raw meat Nutrition 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 240000007906 Aidia cochinchinensis Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 241000208367 Euonymus Species 0.000 abstract 1
- 241000123866 Homalomena occulta Species 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 235000013719 Houttuynia cordata Nutrition 0.000 abstract 1
- 240000001659 Oldenlandia diffusa Species 0.000 abstract 1
- 240000000103 Potentilla erecta Species 0.000 abstract 1
- 235000016551 Potentilla erecta Nutrition 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 208000006568 Urinary Bladder Calculi Diseases 0.000 abstract 1
- 229940116257 pepper extract Drugs 0.000 abstract 1
- 229940084038 salix alba bark extract Drugs 0.000 abstract 1
- 210000004905 finger nail Anatomy 0.000 description 8
- 210000000282 nail Anatomy 0.000 description 8
- 241000209094 Oryza Species 0.000 description 5
- 241000220433 Albizia Species 0.000 description 4
- 235000011438 Albizia odoratissima Nutrition 0.000 description 4
- 241000186016 Bifidobacterium bifidum Species 0.000 description 4
- 206010000269 abscess Diseases 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000025962 Crush injury Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 241000725145 Homalomena Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022013 Ingrowing nail Diseases 0.000 description 1
- 208000010195 Onychomycosis Diseases 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 235000017663 capsaicin Nutrition 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000005882 tinea unguium Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/105—Persulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a matching agent for treating paronychia. The matching agent is prepared from a fermentation and sterilization aqueous solution and concentrated cream. The fermentation and sterilization aqueous solution is prepared from, by weight, 10-13 parts of euonymus fortune, 10-13 parts of houttuynia cordata, 8-10 parts of sulphur, 20-25 parts of herba leonuri, 5-7 parts of ground beetles, 3-7 parts of cortex albiziae, 9-12 parts of pepper extract, 3-7 parts of hedyotis diffusa and 3-7 parts of herb of shiny cinquefoil. The concentrated cream is prepared from, by weight, 1-2 parts of dog cystolith, 3-5 parts of white willow bark extract, 3-5 parts of randia cochinchinensis, 3-5 parts of ox horns, 8-10 parts of spina date seeds, 1-2 parts of homalomena occulta, 3-5 parts of lnula cappa DC., 3-5 parts of radix angelicae pubescentis and 3-5 parts of Michdia yunnanensis Franch. The matching agent has the advantages of being low in cost, rapid in effect taking and high in cure rate.
Description
Technical field
The present invention relates to the field of Chinese medicines.It is more particularly related to one treats paronychial medicament for matching.
Background technology
Paronychia many because of nail groove and tissue around thereof stab, abrade, ingrowing nail or cause subungual abscess, often after pulling out " prickle "
Being spread by paronychia to stab under generation or first causes infection or finger tip crush injury to cause hematoma under nail secondary infection, and pathogenic bacterium are main
It it is staphylococcus aureus.Paronychia from the beginning of time side nail groove generation congestion and swelling pain, in the short time can suppurative infection, diffusible
To fingernail root and offside nail groove, form perionychia, it is possible to diffusing to be formed under first subungual abscess, now the pain increased,
Swelling is obvious, and below fingernail, visible yellow-white pus is by fingernail levitating, can develop into felon as disposed not in time
Even cause digital osteomyelitis, it is possible to become chronic paronychia, prolonged paronychia or the subungual abscess of not healing, shallow compared with table because infecting,
Therefore General Symptoms is the most inconspicuous.
Summary of the invention
It is an object of the invention to solve at least the above, and the advantage that at least will be described later is provided.
It is a still further object of the present invention to provide a kind of low cost, instant effect, the paronychial medicament for matching for the treatment of that cure rate is high.
In order to realize according to object of the present invention and further advantage, it is provided that one treats paronychial medicament for matching, institute
State medicament for matching by ferment sterilization water preparation and condensed cream form；
Wherein, described fermentation sterilization water preparation includes the raw material of following weight portion meter: 10-13 part Caulis Seu Folium Euonymi Fortunei, 10-13 part Herba Houttuyniae,
8-10 part sulfur, 20-25 part Herba Leonuri, 5-7 part Eupolyphaga Seu Steleophaga, 3-7 part Cortex Albiziae, 9-12 part Fructus Zanthoxyli extract, 3-7 part
Hedyotidis Diffusae and 3-7 part Herba potentillae fulgentis；
Described condensed cream includes the raw material of following weight portion meter: 1-2 part Calculus Canitis, 3-5 part Salix Babylonica L.P.E, 3-5 part mountain are yellow
Skin, 3-5 part Cornu Bovis seu Bubali, 8-10 part Semen Ziziphi Spinosae, 1-2 part Rhizoma Homalomenae, 3-5 part flour wind, 3-5 part Radix Angelicae Pubescentis and 3-5 part sack made by leather
Fragrant.
Preferably, described Caulis Seu Folium Euonymi Fortunei, described Herba Houttuyniae, described sulfur, described Herba Leonuri, described Eupolyphaga Seu Steleophaga, described conjunction
Joyous skin, described Fructus Zanthoxyli extract, described Hedyotidis Diffusae and described Herba potentillae fulgentis pulverized 150 mesh sieves respectively.
Preferably, the preparation method of described fermentation sterilization water preparation comprises the following steps:
A1: by the Herba Houttuyniae of above-mentioned parts by weight, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis mix homogeneously, through alcohol reflux,
Obtain ethanol extract, described ethanol extract adds the water of 30 weight portions, and adjusts pH value to 4.5, add 20-30 weight portion
Glucose and the fish flour of 10-15 weight portion, and be that 5%-7% accesses bifidobacteria infantis by inoculum concentration, it is 45 DEG C in temperature
Lower anaerobic fermentation 12-14 days, filters, obtains the first fermentation liquid；
A2: the mixing of the Caulis Seu Folium Euonymi Fortunei of above-mentioned weight portion, sulfur, Eupolyphaga Seu Steleophaga, Cortex Albiziae and Fructus Zanthoxyli extract is added 60 weight
The washing water of rice of part stirs, and after using ultraviolet sterilization, is 2% access Lactobacillus fermenti by inoculum concentration, is 42 DEG C in temperature
Lower anaerobic fermentation 12-14 days, filters, obtains the second fermentation liquid；
A3: described first fermentation liquid and described second fermentation liquid are mixed to obtain mixed fermentation liquid, by described mixed fermentation liquid slow fire
Decoct, be concentrated into the 1/2 of original volume, obtain described fermentation sterilization water preparation.
Preferably, in described A3, in described mixed fermentation liquid decoction process, it is also added into allicin, described Bulbus Allii
The addition of Capsaicin is the 1/20-1/30 of described mixed fermentation liquid quality.
Preferably, in described A1 alcohol reflux particularly as follows: by Herba Houttuyniae, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis altogether
With being the ethanol of 75% by volume fraction, reflux, extract, 4 times, united extraction liquid, reduce pressure Distillation recovery ethanol, obtains described
Ethanol extract.
Preferably, the preparation method of described condensed cream comprises the following steps:
B1: by the Calculus Canitis of above-mentioned weight portion, Salix Babylonica L.P.E, Cortex Clausenae Excavatae, Cornu Bovis seu Bubali, Semen Ziziphi Spinosae, Rhizoma Homalomenae, flour wind,
Radix Angelicae Pubescentis and sack made by leather smoked bean curd dry be less than 10% to water content, pulverized 80 mesh sieves, obtained xeraphium；
B2: by the acetone soln reflux, extract, that described xeraphium volume fraction is 60%, Extracting temperature is set to 65 DEG C
-75 DEG C, extraction time is 3 hours, extracts 2-3 time, and united extraction liquid obtains xeraphium extracting solution；
B3: by described xeraphium extracting solution concentrating under reduced pressure, and reclaim acetone solvent, obtain thick extractum, in described thick extractum
Add with the sodium alginate after water-dispersible, stir, obtain described condensed cream；Wherein, the consumption of described sodium alginate is
The 0.8% of described thick extractum quality.
Preferably, in described B3 concentrating under reduced pressure pressure be-0.09MPa, temperature is 60 DEG C.
Preferably, described sodium alginate is dissolved as matter particularly as follows: add water by the method adding sodium alginate in described B3
Amount mark is the sodium alginate soln of 1%-3%, adds described sodium alginate soln while stirring, and stirring continues to making
State thick extractum surface and form layer of gel.
Preferably, described condensed cream and fermentation sterilization water preparation 2:5 in mass ratio coordinate.
The present invention at least includes following beneficial effect: the paronychial medicament for matching for the treatment of of the present invention is Chinese medicine formula, to human body
Toxic and side effects is minimum, and curative effect is high, short treating period, is dissolved in water by fermentation antibacterial, soaks site of disease, and sterilizing ability is strong,
Can accelerate to soften fingernail, the most certain lenitive effect；With condensed cream and fermentation sterilized water after mollities unguium
Agent is pressed 2:5 and is coordinated, and is coated on affected part, can kill obstinate pathogenic bacteria, have significant antiinflammation simultaneously, and condensed cream is gel
It is comfortable free of a burden that shape is coated on affected part, can effectively prevent paronychial recurrence, reach radical cure curative effect, thoroughly kill fungus,
Staphylococcus aureus and mycete etc. cause paronychial pathogenic bacteria.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will be by the present invention
Research and practice and be understood by the person skilled in the art.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, to make those skilled in the art with reference to description word
Can implement according to this.
Embodiment 1
One treats paronychial medicament for matching, described medicament for matching by ferment sterilization water preparation and condensed cream form；
Wherein, described fermentation sterilization water preparation includes the raw material of following weight portion meter: 10 portions of Caulis Seu Folium Euonymi Fortuneis, 10 parts of Herba Houttuyniae, 8
Part sulfur, 20 parts of Herba Leonuris, 5 parts of Eupolyphaga Seu Steleophagas, 3 portions of Cortex Albiziaes, 9 parts of Fructus Zanthoxyli extracts, 3 parts of Hedyotidis Diffusaes and 3 parts
Herba potentillae fulgentis.Said medicine pulverized 150 mesh sieves respectively.
The preparation method of described fermentation sterilization water preparation comprises the following steps:
A1: by the Herba Houttuyniae of above-mentioned parts by weight, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis mix homogeneously, through alcohol reflux,
Particularly as follows: be the ethanol of 75% by volume fraction jointly by Herba Houttuyniae, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis, reflux, extract, 4
Secondary, united extraction liquid, reduce pressure Distillation recovery ethanol, obtains ethanol extract.The water of 30 weight portions is added in described ethanol extract,
And adjust pH value to 4.5, add glucose and the fish flour of 10 weight portions of 20 weight portions, and be 5% access baby by inoculum concentration
Youngster's bacillus bifidus, anaerobic fermentation 12 days at temperature is 45 DEG C, filter, obtain the first fermentation liquid；
A2: the mixing of the Caulis Seu Folium Euonymi Fortunei of above-mentioned weight portion, sulfur, Eupolyphaga Seu Steleophaga, Cortex Albiziae and Fructus Zanthoxyli extract is added 60 weight
The washing water of rice of part stirs, and after using ultraviolet sterilization, is 2% access Lactobacillus fermenti by inoculum concentration, is 42 DEG C in temperature
Lower anaerobic fermentation 12 days, filters, obtains the second fermentation liquid；
A3: described first fermentation liquid and described second fermentation liquid are mixed to obtain mixed fermentation liquid, by described mixed fermentation liquid slow fire
Decocting, add allicin in decoction process, the addition of described allicin is described mixed fermentation liquid quality
1/20, the 1/2 of decocting and concentrating to original volume, obtain described fermentation sterilization water preparation.
Described condensed cream includes the raw material of following weight portion meter: 1 part of Calculus Canitis, 3 parts of Salix Babylonica L.P.Es, 3 parts of Cortex Clausenae Excavataes, 3
Part Cornu Bovis seu Bubali, 8 parts of Semen Ziziphi Spinosaes, 1 part of Rhizoma Homalomenae, 3 parts of flour wind, 3 parts of Radix Angelicae Pubescentiss and 3 parts of sack made by leather perfume (or spice).
The preparation method of described condensed cream comprises the following steps:
B1: by the Calculus Canitis of above-mentioned weight portion, Salix Babylonica L.P.E, Cortex Clausenae Excavatae, Cornu Bovis seu Bubali, Semen Ziziphi Spinosae, Rhizoma Homalomenae, flour wind,
Radix Angelicae Pubescentis and sack made by leather smoked bean curd dry be less than 10% to water content, pulverized 80 mesh sieves, obtained xeraphium；
B2: by the acetone soln reflux, extract, that described xeraphium volume fraction is 60%, Extracting temperature is set to 65 DEG C,
Extraction time is 3 hours, extracts 2 times, united extraction liquid, obtains xeraphium extracting solution；
B3: by described xeraphium extracting solution concentrating under reduced pressure, concentrating under reduced pressure pressure be-0.09MPa, temperature is 60 DEG C,
And reclaim acetone solvent, obtain thick extractum.Described thick extractum adds with the sodium alginate after water-dispersible, stirs,
Obtain described condensed cream；Wherein, the consumption of described sodium alginate is the 0.8% of described thick extractum quality.Described B3 adds
The method of sodium alginate is particularly as follows: add water and described sodium alginate is dissolved as the sodium alginate soln that mass fraction is 1%, limit
Stirring limit adds described sodium alginate soln, and stirring continues to making described thick extractum surface form layer of gel.
Embodiment 2
One treats paronychial medicament for matching, described medicament for matching by ferment sterilization water preparation and condensed cream form；
Wherein, described fermentation sterilization water preparation includes the raw material of following weight portion meter: 13 portions of Caulis Seu Folium Euonymi Fortuneis, 13 parts of Herba Houttuyniae, 10
Part sulfur, 25 parts of Herba Leonuris, 7 parts of Eupolyphaga Seu Steleophagas, 7 portions of Cortex Albiziaes, 12 parts of Fructus Zanthoxyli extracts, 7 parts of Hedyotidis Diffusaes and 7 parts
Herba potentillae fulgentis.Said medicine pulverized 150 mesh sieves respectively.
The preparation method of described fermentation sterilization water preparation comprises the following steps:
A1: by the Herba Houttuyniae of above-mentioned parts by weight, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis mix homogeneously, through alcohol reflux,
Particularly as follows: be the ethanol of 75% by volume fraction jointly by Herba Houttuyniae, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis, reflux, extract, 4
Secondary, united extraction liquid, reduce pressure Distillation recovery ethanol, obtains ethanol extract.The water of 30 weight portions is added in described ethanol extract,
And adjust pH value to 4.5, add glucose and the fish flour of 15 weight portions of 30 weight portions, and be 7% access baby by inoculum concentration
Youngster's bacillus bifidus, anaerobic fermentation 14 days at temperature is 45 DEG C, filter, obtain the first fermentation liquid；
A2: the mixing of the Caulis Seu Folium Euonymi Fortunei of above-mentioned weight portion, sulfur, Eupolyphaga Seu Steleophaga, Cortex Albiziae and Fructus Zanthoxyli extract is added 60 weight
The washing water of rice of part stirs, and after using ultraviolet sterilization, is 2% access Lactobacillus fermenti by inoculum concentration, is 42 DEG C in temperature
Lower anaerobic fermentation 14 days, filters, obtains the second fermentation liquid；
A3: described first fermentation liquid and described second fermentation liquid are mixed to obtain mixed fermentation liquid, by described mixed fermentation liquid slow fire
Decocting, add allicin in decoction process, the addition of described allicin is described mixed fermentation liquid quality
1/30, the 1/2 of decocting and concentrating to original volume, obtain described fermentation sterilization water preparation.
Described condensed cream includes the raw material of following weight portion meter: 2 parts of Calculus Canitis, 5 parts of Salix Babylonica L.P.Es, 5 parts of Cortex Clausenae Excavataes, 5
Part Cornu Bovis seu Bubali, 10 parts of Semen Ziziphi Spinosaes, 2 parts of Rhizoma Homalomenaes, 5 parts of flour wind, 5 parts of Radix Angelicae Pubescentiss and 5 parts of sack made by leather perfume (or spice).
The preparation method of described condensed cream comprises the following steps:
B1: by the Calculus Canitis of above-mentioned weight portion, Salix Babylonica L.P.E, Cortex Clausenae Excavatae, Cornu Bovis seu Bubali, Semen Ziziphi Spinosae, Rhizoma Homalomenae, flour wind,
Radix Angelicae Pubescentis and sack made by leather smoked bean curd dry be less than 10% to water content, pulverized 80 mesh sieves, obtained xeraphium；
B2: by the acetone soln reflux, extract, that described xeraphium volume fraction is 60%, Extracting temperature is set to 75 DEG C,
Extraction time is 3 hours, extracts 3 times, united extraction liquid, obtains xeraphium extracting solution；
B3: by described xeraphium extracting solution concentrating under reduced pressure, concentrating under reduced pressure pressure be-0.09MPa, temperature is 60 DEG C,
And reclaim acetone solvent, obtain thick extractum.Described thick extractum adds with the sodium alginate after water-dispersible, stirs,
Obtain described condensed cream；Wherein, the consumption of described sodium alginate is the 0.8% of described thick extractum quality.Described B3 adds
The method of sodium alginate is particularly as follows: add water and described sodium alginate is dissolved as the sodium alginate soln that mass fraction is 3%, limit
Stirring limit adds described sodium alginate soln, and stirring continues to making described thick extractum surface form layer of gel.
Embodiment 3
One treats paronychial medicament for matching, described medicament for matching by ferment sterilization water preparation and condensed cream form；
Wherein, described fermentation sterilization water preparation includes the raw material of following weight portion meter: 11 parts of Caulis Seu Folium Euonymi Fortuneis, 11 parts of Herba Houttuyniae, 8-10
Part sulfur, 22 parts of Herba Leonuris, 6 parts of Eupolyphaga Seu Steleophagas, 5 portions of Cortex Albiziaes, 11 parts of Fructus Zanthoxyli extracts, 5 parts of Hedyotidis Diffusaes and 5 parts
Herba potentillae fulgentis.Said medicine pulverized 150 mesh sieves respectively.
The preparation method of described fermentation sterilization water preparation comprises the following steps:
A1: by the Herba Houttuyniae of above-mentioned parts by weight, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis mix homogeneously, through alcohol reflux,
Particularly as follows: be the ethanol of 75% by volume fraction jointly by Herba Houttuyniae, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis, reflux, extract, 4
Secondary, united extraction liquid, reduce pressure Distillation recovery ethanol, obtains ethanol extract.The water of 30 weight portions is added in described ethanol extract,
And adjust pH value to 4.5, add glucose and the fish flour of 12 weight portions of 25 weight portions, and be 6% access baby by inoculum concentration
Youngster's bacillus bifidus, anaerobic fermentation 13 days at temperature is 45 DEG C, filter, obtain the first fermentation liquid；
A2: the mixing of the Caulis Seu Folium Euonymi Fortunei of above-mentioned weight portion, sulfur, Eupolyphaga Seu Steleophaga, Cortex Albiziae and Fructus Zanthoxyli extract is added 60 weight
The washing water of rice of part stirs, and after using ultraviolet sterilization, is 2% access Lactobacillus fermenti by inoculum concentration, is 42 DEG C in temperature
Lower anaerobic fermentation 13 days, filters, obtains the second fermentation liquid；
A3: described first fermentation liquid and described second fermentation liquid are mixed to obtain mixed fermentation liquid, by described mixed fermentation liquid slow fire
Decoct, decoction process adds allicin, as natural preservative, can improve the holding time of medicament, simultaneously
Also having bactericidal action, the addition of described allicin is the 1/23 of described mixed fermentation liquid quality, and decocting and concentrating is to substance
Long-pending 1/2, obtains described fermentation sterilization water preparation.
Described condensed cream includes the raw material of following weight portion meter: 1 part of Calculus Canitis, 4 parts of Salix Babylonica L.P.Es, 4 parts of Cortex Clausenae Excavataes, 4
Part Cornu Bovis seu Bubali, 9 parts of Semen Ziziphi Spinosaes, 1 part of Rhizoma Homalomenae, 4 parts of flour wind, 4 parts of Radix Angelicae Pubescentiss and 4 parts of sack made by leather perfume (or spice).
The preparation method of described condensed cream comprises the following steps:
B1: by the Calculus Canitis of above-mentioned weight portion, Salix Babylonica L.P.E, Cortex Clausenae Excavatae, Cornu Bovis seu Bubali, Semen Ziziphi Spinosae, Rhizoma Homalomenae, flour wind,
Radix Angelicae Pubescentis and sack made by leather smoked bean curd dry be less than 10% to water content, pulverized 80 mesh sieves, obtained xeraphium；
B2: by the acetone soln reflux, extract, that described xeraphium volume fraction is 60%, Extracting temperature is set to 68 DEG C,
Extraction time is 3 hours, extracts 3 times, united extraction liquid, obtains xeraphium extracting solution；
B3: by described xeraphium extracting solution concentrating under reduced pressure, concentrating under reduced pressure pressure be-0.09MPa, temperature is 60 DEG C,
And reclaim acetone solvent, obtain thick extractum.Described thick extractum adds with the sodium alginate after water-dispersible, stirs,
Obtain described condensed cream；Wherein, the consumption of described sodium alginate is the 0.8% of described thick extractum quality.Described B3 adds
The method of sodium alginate is particularly as follows: add water and described sodium alginate is dissolved as the sodium alginate soln that mass fraction is 2%, limit
Stirring limit adds described sodium alginate soln, and stirring continues to making described thick extractum surface form layer of gel.Use alginic acid
Sodium forms gel and extends the shelf-life of thick paste on thick extractum surface.
Matched group 1
One treats paronychial medicament for matching, and described medicament for matching is made up of the sterilization water preparation that ferments.
Wherein, described fermentation sterilization water preparation includes the raw material of following weight portion meter: 11 parts of Caulis Seu Folium Euonymi Fortuneis, 11 parts of Herba Houttuyniae, 8-10
Part sulfur, 22 parts of Herba Leonuris, 6 parts of Eupolyphaga Seu Steleophagas, 5 portions of Cortex Albiziaes, 11 parts of Fructus Zanthoxyli extracts, 5 parts of Hedyotidis Diffusaes and 5 parts
Herba potentillae fulgentis.Said medicine pulverized 150 mesh sieves respectively.
The preparation method of described fermentation sterilization water preparation comprises the following steps:
A1: by the Herba Houttuyniae of above-mentioned parts by weight, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis mix homogeneously, through alcohol reflux,
Particularly as follows: be the ethanol of 75% by volume fraction jointly by Herba Houttuyniae, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis, reflux, extract, 4
Secondary, united extraction liquid, reduce pressure Distillation recovery ethanol, obtains ethanol extract.The water of 30 weight portions is added in described ethanol extract,
And adjust pH value to 4.5, add glucose and the fish flour of 12 weight portions of 25 weight portions, and be 6% access baby by inoculum concentration
Youngster's bacillus bifidus, anaerobic fermentation 13 days at temperature is 45 DEG C, filter, obtain the first fermentation liquid；
A2: the mixing of the Caulis Seu Folium Euonymi Fortunei of above-mentioned weight portion, sulfur, Eupolyphaga Seu Steleophaga, Cortex Albiziae and Fructus Zanthoxyli extract is added 60 weight
The washing water of rice of part stirs, and after using ultraviolet sterilization, is 2% access Lactobacillus fermenti by inoculum concentration, is 42 DEG C in temperature
Lower anaerobic fermentation 13 days, filters, obtains the second fermentation liquid；
A3: described first fermentation liquid and described second fermentation liquid are mixed to obtain mixed fermentation liquid, by described mixed fermentation liquid slow fire
Decocting, add allicin in decoction process, the addition of described allicin is described mixed fermentation liquid quality
1/23, the 1/2 of decocting and concentrating to original volume, obtain described fermentation sterilization water preparation.
Matched group 2
One treats paronychial medicament for matching, and described medicament for matching is made up of condensed cream.
Described condensed cream includes the raw material of following weight portion meter: 1 part of Calculus Canitis, 4 parts of Salix Babylonica L.P.Es, 4 parts of Cortex Clausenae Excavataes, 4
Part Cornu Bovis seu Bubali, 9 parts of Semen Ziziphi Spinosaes, 1 part of Rhizoma Homalomenae, 4 parts of flour wind, 4 parts of Radix Angelicae Pubescentiss and 4 parts of sack made by leather perfume (or spice).
The preparation method of described condensed cream comprises the following steps:
B1: by the Calculus Canitis of above-mentioned weight portion, Salix Babylonica L.P.E, Cortex Clausenae Excavatae, Cornu Bovis seu Bubali, Semen Ziziphi Spinosae, Rhizoma Homalomenae, flour wind,
Radix Angelicae Pubescentis and sack made by leather smoked bean curd dry be less than 10% to water content, pulverized 80 mesh sieves, obtained xeraphium；
B2: by the acetone soln reflux, extract, that described xeraphium volume fraction is 60%, Extracting temperature is set to 68 DEG C,
Extraction time is 3 hours, extracts 3 times, united extraction liquid, obtains xeraphium extracting solution；
B3: by described xeraphium extracting solution concentrating under reduced pressure, concentrating under reduced pressure pressure be-0.09MPa, temperature is 60 DEG C,
And reclaim acetone solvent, obtain thick extractum.Described thick extractum adds with the sodium alginate after water-dispersible, stirs,
Obtain described condensed cream；Wherein, the consumption of described sodium alginate is the 0.8% of described thick extractum quality.Described B3 adds
The method of sodium alginate is particularly as follows: add water and described sodium alginate is dissolved as the sodium alginate soln that mass fraction is 2%, limit
Stirring limit adds described sodium alginate soln, and stirring continues to making described thick extractum surface form layer of gel.
Clinical trial:
300 example paronychia patients local to Nanning carry out clinical observation treatment, and wherein male's case is 145 examples, women case
Being 155 examples, the mean age is 18-65 year, 45 years old mean age.It is randomly divided into 3 groups, often organizes 100 people, treatment group 1
Using embodiment 3 to treat, treatment group 2 uses matched group 1 to treat, and treatment group 3 uses matched group 2 to treat.
Clinical symptoms: affected part local pain, fingernail grows in nail groove, touching i.e. pain；When having inflammation, subungual abscess,
Have and newly granulate outwardly.
Therapeutic Method:
External, wherein:
After the fermentation treated in the paronychial medicament for matching sterilization water preparation that embodiment 3 prepares is mixed by 1:100 with water, soak
Affected part 20-40min, dries fingernail, then by 2:5 cooperation, condensed cream and fermentation sterilization water preparation is coated on diseased nails surface
And around skin, wrap gauze, once a day, within continuous 7 days, it is a course for the treatment of.
In the paronychial medicament for matching for the treatment of that matched group 1 prepares, after fermentation sterilization water preparation is mixed by 1:100 with water, soak
Tinea unguium 20-40min, dries fingernail, is then coated on around diseased nails surface and skin thereof by fermentation sterilization water preparation, bag
Good gauze, once a day, continuous 7 days is a course for the treatment of.
In the paronychial medicament for matching for the treatment of that matched group 2 prepares, after cleaning clean fingernail, dry, condensed cream is coated on
Around diseased nails surface and skin thereof, wrap gauze, once a day, within continuous 7 days, be a course for the treatment of.
Outcome measure:
Curing, clinical symptoms all disappears, and within more than 1 year, has no recurrence；
Effectively, clinical symptom relief or improvement；
Invalid, clinical symptoms is without taking a turn for the better or improving.
Therapeutic outcome:
| Group | Healing/example | Effectively/example | Do not heal/example |
| Treatment group 1 | 99 | 1 | 0 |
| Treatment group 2 | 74 | 22 | 4 |
| Treatment group 3 | 80 | 18 | 2 |
Although embodiment of the present invention are disclosed as above, but it is not restricted in description and embodiment listed fortune
With, it can be applied to various applicable the field of the invention completely, for those skilled in the art, and can be easily
Realizing other amendment, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention does not limit
In specific details with shown here as the embodiment with description.
Claims (9)
1. treat paronychial medicament for matching for one kind, it is characterised in that described medicament for matching is by sterilization water preparation and the concentration of fermenting
Cream forms；
Wherein, described fermentation sterilization water preparation includes the raw material of following weight portion meter: 10-13 part Caulis Seu Folium Euonymi Fortunei, 10-13 part Herba Houttuyniae,
8-10 part sulfur, 20-25 part Herba Leonuri, 5-7 part Eupolyphaga Seu Steleophaga, 3-7 part Cortex Albiziae, 9-12 part Fructus Zanthoxyli extract, 3-7 part
Hedyotidis Diffusae and 3-7 part Herba potentillae fulgentis；
Described condensed cream includes the raw material of following weight portion meter: 1-2 part Calculus Canitis, 3-5 part Salix Babylonica L.P.E, 3-5 part mountain are yellow
Skin, 3-5 part Cornu Bovis seu Bubali, 8-10 part Semen Ziziphi Spinosae, 1-2 part Rhizoma Homalomenae, 3-5 part flour wind, 3-5 part Radix Angelicae Pubescentis and 3-5 part sack made by leather
Fragrant.
2. the paronychial medicament for matching for the treatment of as claimed in claim 1, it is characterised in that described Caulis Seu Folium Euonymi Fortunei, described fish
Raw meat sulfur careless, described, described Herba Leonuri, described Eupolyphaga Seu Steleophaga, described Cortex Albiziae, described Fructus Zanthoxyli extract, described Agkistrodon
Careless and described Herba potentillae fulgentis pulverized 150 mesh sieves respectively.
3. the paronychial medicament for matching for the treatment of as claimed in claim 2, it is characterised in that described fermentation sterilization water preparation
Preparation method comprises the following steps:
A1: by the Herba Houttuyniae of above-mentioned parts by weight, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis mix homogeneously, through alcohol reflux,
Obtain ethanol extract, described ethanol extract adds the water of 30 weight portions, and adjusts pH value to 4.5, add 20-30 weight portion
Glucose and the fish flour of 10-15 weight portion, and be that 5%-7% accesses bifidobacteria infantis by inoculum concentration, it is 45 DEG C in temperature
Lower anaerobic fermentation 12-14 days, filters, obtains the first fermentation liquid；
A2: the mixing of the Caulis Seu Folium Euonymi Fortunei of above-mentioned weight portion, sulfur, Eupolyphaga Seu Steleophaga, Cortex Albiziae and Fructus Zanthoxyli extract is added 60 weight
The washing water of rice of part stirs, and after using ultraviolet sterilization, is 2% access Lactobacillus fermenti by inoculum concentration, is 42 DEG C in temperature
Lower anaerobic fermentation 12-14 days, filters, obtains the second fermentation liquid；
A3: described first fermentation liquid and described second fermentation liquid are mixed to obtain mixed fermentation liquid, by described mixed fermentation liquid slow fire
Decoct, be concentrated into the 1/2 of original volume, obtain described fermentation sterilization water preparation.
4. the paronychial medicament for matching for the treatment of as claimed in claim 3, it is characterised in that in described A3, described mixed
Closing in fermentation liquid decoction process and be also added into allicin, the addition of described allicin is described mixed fermentation liquid quality
1/20-1/30。
5. the paronychial medicament for matching for the treatment of as claimed in claim 3, it is characterised in that in described A1, alcohol reflux carries
Take particularly as follows: be the ethanol of 75% by volume fraction jointly by Herba Houttuyniae, Herba Leonuri, Hedyotidis Diffusae and Herba potentillae fulgentis, reflux, extract,
4 times, united extraction liquid, reduce pressure Distillation recovery ethanol, obtains described ethanol extract.
6. the paronychial medicament for matching for the treatment of as claimed in claim 2, it is characterised in that the preparation side of described condensed cream
Method comprises the following steps:
B1: by the Calculus Canitis of above-mentioned weight portion, Salix Babylonica L.P.E, Cortex Clausenae Excavatae, Cornu Bovis seu Bubali, Semen Ziziphi Spinosae, Rhizoma Homalomenae, flour wind,
Radix Angelicae Pubescentis and sack made by leather smoked bean curd dry be less than 10% to water content, pulverized 80 mesh sieves, obtained xeraphium；
B2: by the acetone soln reflux, extract, that described xeraphium volume fraction is 60%, Extracting temperature is set to 65 DEG C
-75 DEG C, extraction time is 3 hours, extracts 2-3 time, and united extraction liquid obtains xeraphium extracting solution；
B3: by described xeraphium extracting solution concentrating under reduced pressure, and reclaim acetone solvent, obtain thick extractum, in described thick extractum
Add with the sodium alginate after water-dispersible, stir, obtain described condensed cream；Wherein, the consumption of described sodium alginate is
The 0.8% of described thick extractum quality.
7. the paronychial medicament for matching for the treatment of as claimed in claim 6, it is characterised in that concentrating under reduced pressure in described B3
Pressure be-0.09MPa, temperature is 60 DEG C.
8. the paronychial medicament for matching for the treatment of as claimed in claim 6, it is characterised in that add Sargassum in described B3
Acid sodium method particularly as follows: add water and described sodium alginate be dissolved as the sodium alginate soln that mass fraction is 1%-3%,
Adding described sodium alginate soln while stirring, stirring continues to making described thick extractum surface form layer of gel.
9. the paronychial medicament for matching for the treatment of as claimed in claim 1, it is characterised in that described condensed cream and fermentation
Sterilization water preparation 2:5 in mass ratio coordinates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610368355.5A CN105878531A (en) | 2016-05-27 | 2016-05-27 | Matching agent for treating paronychia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610368355.5A CN105878531A (en) | 2016-05-27 | 2016-05-27 | Matching agent for treating paronychia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105878531A true CN105878531A (en) | 2016-08-24 |
Family
ID=56710744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610368355.5A Pending CN105878531A (en) | 2016-05-27 | 2016-05-27 | Matching agent for treating paronychia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105878531A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101693040A (en) * | 2009-10-14 | 2010-04-14 | 许保通 | Medicament for treating onychomycosis and preparation method thereof |
| CN102526246A (en) * | 2012-01-22 | 2012-07-04 | 李志勇 | Externally-used ointment for relieving paronychia pain |
| CN104800344A (en) * | 2015-04-22 | 2015-07-29 | 喻朝阳 | Traditional Chinese medicine preparation for treating onychomycosis and preparation method thereof |
| CN105497531A (en) * | 2014-11-28 | 2016-04-20 | 唐训芝 | Traditional Chinese medicine for treating paronychia |
-
2016
- 2016-05-27 CN CN201610368355.5A patent/CN105878531A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101693040A (en) * | 2009-10-14 | 2010-04-14 | 许保通 | Medicament for treating onychomycosis and preparation method thereof |
| CN102526246A (en) * | 2012-01-22 | 2012-07-04 | 李志勇 | Externally-used ointment for relieving paronychia pain |
| CN105497531A (en) * | 2014-11-28 | 2016-04-20 | 唐训芝 | Traditional Chinese medicine for treating paronychia |
| CN104800344A (en) * | 2015-04-22 | 2015-07-29 | 喻朝阳 | Traditional Chinese medicine preparation for treating onychomycosis and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN103751310B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating fascitis | |
| CN108853278A (en) | Dredging collateral and promoting blood circulation qi-regulating is dried easypro bone compositions and preparation method thereof | |
| CN106421392A (en) | Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel | |
| CN108355042A (en) | A kind of anti-inflammatory analgetic ointment and preparation method thereof | |
| CN106727967A (en) | Chinese yew lavipeditum powder and preparation method | |
| CN102961633B (en) | A kind of preparation for being used to treat postpartum rheumatism | |
| CN105878531A (en) | Matching agent for treating paronychia | |
| CN101559108B (en) | Chinese medicinal preparation for treating beriberi, tinea corporis, tinea cruris and method for preparing same | |
| CN105380964A (en) | Medicated bath product and preparation method thereof | |
| CN1994380B (en) | Externally applied medicine for treating arthritis, hot pack and preparation method thereof | |
| CN104352737A (en) | Traditional Chinese medicinal preparation for treating rheumatic low back and leg pain | |
| CN103656438B (en) | Nursing medicine for spine postoperative cuts | |
| CN111700989B (en) | Traditional Chinese medicine composition for dispelling wind, eliminating dampness and treating tinea pedis and preparation method thereof | |
| CN103735874B (en) | A kind of nursing powder for wound after wound healing and preparation method thereof | |
| CN107998204B (en) | Traditional Chinese medicine pedicure medicine prescription for treating tinea pedis, beriberi, foot odor and pruritus and preparation method thereof | |
| CN104971209A (en) | Externally used agent for treating tinea pedis and preparation method thereof | |
| CN103690865B (en) | A kind of spinal surgery postoperative wound nursing powder and preparation method thereof | |
| CN103285109A (en) | Chinese herbal medicine for treating bone fracture and preparation method thereof | |
| CN103100023B (en) | External medicinal liquor for treating skin diseases and preparation method thereof | |
| CN103893648A (en) | Traditional Chinese medicine for treating fatty liver | |
| CN109419996A (en) | A kind of Chinese medicine that treating bacterial vaginitis and preparation method | |
| CN105878515A (en) | Matching agent for treating onychomycosis | |
| CN108403880A (en) | A kind of seedling medicine and preparation method thereof for treating burn | |
| CN107050196A (en) | External medicine composition, preparation method and application and herbal medicine immersion agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160824 |