CN105380964A - Medicated bath product and preparation method thereof - Google Patents

Abstract

The invention relates to a medicated bath product and a preparation method thereof and belongs to the field of health-care life-nourishing products. The medicated bath product is formed by fermenting a mixture containing, by weight, 10-30% of pine tips and 70-90% of pine wood powder. The mixture further comprises, by weight, 60-65% of water. According to fermentation, the mixture is smashed and subjected to normal-temperature ultra-high-pressure sterilization and cooling, water is added for building a pile and fermentation, and then the pile is turned again for refermentation. The invention further provides a preparation method of the medicated bath product on the basis of the preceding fermentation steps. The invention further provides medicated bath pulp based on the medicated bath product, and the medicated bath product is protected to have application to preparing medicated bath articles with the effect of promoting the blood circulation to stop pain and/or preparing external medicine with the effect of promoting the blood circulation to stop pain. According to the medicated bath product, raw material sources are sufficient, composition matching is easy, the materials are environmentally friendly, cost is low, and the product has good effects of circulating the blood circulation, stopping pain, repelling wind, killing insects, adjusting the blood pressure and softening blood vessels. The preparation method is simple in process and easy to operate, and the obtained product has more remarkable effects.

Description

A kind of dipping goods and preparation method thereof

Technical field

The invention belongs to Chinese medicine health-care external product technology, being specifically related to a kind of is dipping goods of main component and preparation method thereof with loose point/Masson Pine end.

Background technology

Dipping, in the traditional Chinese medical science, is one of external treatment, and namely by medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, its form is varied: have full bath and claim " liquid medicine bath "; The title having again " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most conventional.Dipping medication is the same with oral medicine, also needs to follow prescription principle, and differential diagnosis of diseases is dialectical, carefully selects medicine, and according to factors such as respective body constitution, time, place, the state of an illness, selects different square medicines, recognizing what every symptom or sign is attributed to.

The dipping side controlling baby's epilepsy is just had in hospital the earliest of China " 52 Bingfang ".Say in " Book of Rites " " head has skin ulcer then to wash one's hair, and body has infections then to bathe ", have in Huangdi's Internal Classics " it is by exopathogen person; bathing the body with hot decoction to induce diaphoresis " record---can say, the history of dipping is of long standing and well established, is laid a foundation in the Qin Dynasty, develop in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.Shanxi, north and south, Sui-Tang bines, development of clinical medicine is rapid, and dipping is widely used clinical departments.Song, gold, unit, bright period, the square medicine of dipping is on the increase, and range of application expands gradually, and dipping becomes a kind of conventional Therapeutic Method.Yuan Dynasty Zhou Daguan note in " true wax natural conditions and social customs of a place note " has, and " compatriots are ordinary ill, are mostly to enter water dipping bath and hair washing just can from fullying recover from an illness again and again." visible dipping at that time become a kind for the treatment of method that doctor and the common people at that time commonly use.Arrived the Qing Dynasty, dipping has developed into the prosperous stage, and Qing Dynasty well-known doctor comes forth in large number, and masterpiece is publication in succession.Along with the appearance of the Chinese medicine external treatment monograph such as " first aid is raw collection extensively ", " Li Yue Pianwen, Rhymed Discourse for Topical Remedies ", Traditional Chinese medicine medicated bath therapy has entered comparative maturity and perfect stage.The dipping mechanism of action in general, be drug effect in whole body flesh table, locally, affected part, and through absorb, follow network blood vessels of passing through, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordination internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body and parasite killing.Modern pharmacology also confirms, can improve the content of some immunoglobulin in blood after dipping, strengthens elasticity and the vigor of skin.

Conventional dipping medical material has Herba Cymbopogonis Citrari, Radix Zanthoxyli, Radix Zanthoxyli, the white Folium Artemisiae Argyi in sea, the white Folium Artemisiae Argyi in mountain, little Folium Artemisiae Argyi, mountain is praised, one red, Common Rue Herb, mosquito incense grass, eight blow grass, Limnophila aromatica, Caulis Perillae, perfume (or spice) adds leaf, Folium Cajani, bamboo is parasitic, to pass by one's way perfume (or spice), phoenix Rhizoma Zingiberis Recens, great Lan Rhizoma Zingiberis Recens, Alpinia japonica (Thunb.) Miq., Rhizoma alpiniae chinensis, hook Rhizoma Zingiberis Recens, Flos Caryophylli, ground pickled cucumbers leaf, little pickled cucumbers leaf, flower pears Semen Erythrophlei fourdii powder, Lignum Aquilariae Resinatum, bird is not enough, enter fragrant Laurus nobilis, Herba Pogostemonis, south Herba Pelargonii Graveolentis, Folium Eucalypti Robustae, Fructus Liquidambaris, mountain melon leaf, water Cordyceps, danshuitong, a mountain fire rattan, atalantia buxjfolia, XIEXIANG, cross mountain breeze leaf, five fat wind, three fat wind, duck foot leaf, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Leonuri, mountain house steward, Folium Eriobotryae, hand hay cutter Folium Bambusae, Bai Linye, XIUGUCAO, Flos Plumeriae Acutifoliae, le Herba Pelargonii Graveolentis, night fragrant flower etc.To boil medicine and the concrete grammar of dipping is also worthy of careful study: bind up with gauze after medicine is pulverized (or directly medicine be placed in pot add water take also can).During making, add clear water appropriate, soak 20 minutes, and then boil 30 minutes, medicinal liquid is poured in bathtub, when temperature appropriateness, get final product bathing.In bathing, its method has the fumigation and wash method method of first smoking and bathing afterwards, also has limit to be close to the rubbing bath method of bath.In order to blood circulation promoting, promote the absorption to Chinese medicine, in medicinal liquid, also add the Rhizoma Zingiberis Recens mother patted, and rice wine.

So far, the report playing promoting blood circulation and stopping pain drug effect with pine point and the last form with dipping of Masson Pine is not seen.

Summary of the invention

The present invention is directed to the blank in above-mentioned field, provide a kind of dipping goods being main component with pine point and Masson Pine end, empirical tests, these dipping goods have significant promoting blood circulation and stopping pain, regulate blood pressure, vessel softening, effect of dispeiling pathogenic wind and removing dampness.

Technical scheme of the present invention is as follows:

A kind of dipping goods, is characterized in that, its active ingredient is for pine point with Masson Pine is last obtains through fermentation for crude drug.

In described crude drug, the weight ratio at pine point and Masson Pine end is: 10-30:90-70.

The water content of described dipping goods is 60%-65%.

Described fermentation refers to, after crude drug pulverizing, the sterilizing of room temperature superpressure, add water mixing, and build heap fermentation, then turning is fermented again, and institute's amount of water makes the described dipping goods of fermentation gained reach described water content 40%-60%.

Described pulverizing refers to, described crude drug is ground into the granule being less than or equal to 3 millimeters;

Described sterilizing is: room temperature, deactivation 20 minutes under 1500 MPa supertension, rear cooling,

Described heap of building ferments for after fermentation 48-112 hour, is warming up to 75-78 DEG C;

Described turning is fermented and is referred to that turning after fermentation is after 48-96 hour, until be warming up to 55-60 DEG C.

The described water used that adds water refers to the drinking water being cooled to 60 DEG C after boiling.

A preparation method for dipping goods, comprises the steps:

(1) crude drug is prepared: the weight ratio at pine point and Masson Pine end is: 10-30:90-70;

(2) pulverize;

(3) autoclaving, cooling;

(4) add water mixing, and build heap fermentation, turning is fermented again.

Described pulverizing refers to, under diameter 5 millimeters of eye equipment, described mixture is ground into the granule being less than or equal to 3 millimeters;

Described sterilizing is deactivation 20 minutes under 1500 MPa supertension;

Described heap of building ferments for fermentation is warming up to 75-78 DEG C for 48-112 hour;

Described turning is fermented for after fermentation 48-96 hour again, is warming up to 55-60 DEG C;

Described water refers to the drinking water being cooled to 60 DEG C after boiling.

The purposes of described dipping goods in preparation promoting blood circulation and stopping pain medicine for external use.

A kind of promoting blood circulation and stopping pain medicine for external use, its active ingredient comprises described goods.

The present invention with pine point and Masson Pine last for raw material, by the fermentation technology of rationally scientifically proportioning and improvement, they self therapeutic efficiency is farthest brought into play, make a kind of dipping goods, for the leisure way that user/consumer/patient is loosened by dipping, reach the object of promoting blood circulation and stopping pain.

Raw material described in two kinds is described below:

Song Jian: for the sprout of Pinaceae (Pinaceae) p.massoniana lamb or its congener is most advanced and sophisticated.Warm in nature, bitter and puckery flavor.Being described below it on medical book/ancient books: " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " network of passing through, only pains in the penis, only turbid urine.Control stranguria marked by chyluria and ache unbearably painful person, mill watery wine takes it.Five types of stranguria all can take." " Zhejiang conventional medical herbs among the people ": " invigorating blood circulation analgesia, arresting seminal emission.", [usage and consumption] takes orally: decoct soup, 1 ~ 2 liang; Or mill juice.External: smash deposited.Do not see the report using it as dipping active ingredient.

Masson Pine end is the sawdust of the trees of Pinaceae (Pinaceae) or Pinus (Pinus) plant, owing to being rich in Colophonium in Masson Pine, have another name called Colophonium, the Colophonium of Pinus tabuliformis and Pinus massoniana Lamb is containing abietic anhydride and rosin acid about 80%, resen about 5 ~ 6%, volatile oil about 0.5% and micro-bitter substance; Nature and flavor: bitter; Sweet; Warm in nature.Enter liver, spleen channel.Dispeiling pathogenic wind and removing dampness; Evacuation of pus is drawn out pus by applying a plaster to the affected part; Granulation promoting pain relieving.Main carbuncle malignant boil; Scrofula; Fistula disease; Scabies; Bald in vain; Leprosy; Arthromyodynia; Incised wound; Sprain; Women leucorrhea; Thromboangiitis obliterans.Be applicable to carbuncle furuncle infections, eczema, traumatic hemorrhage, burn and scald.Do not see the report using it as dipping active ingredient.

The invention provides a kind of dipping goods, it comprises containing weight part ratio is product after the pine point of 10-30:90-70 and the last mixed culture fermentation of Masson Pine.As dipping effective ingredient, in dipping environment, active ingredient enters collaterals of human with the Oleum Pini volatile oil component in Masson Pine end via skin, after mixed culture fermentation, two kinds of raw-material effective ingredient can be made fully to discharge, its effective ingredient is more easily absorbed by the body, thus farthest plays its therapeutic efficiency.Further, described mixture can also comprise the water that percentage by weight is 40%-60%.

Particularly, described fermentation refers to, after mixture pulverizing, sterilizing, adds the water that percentage by weight is 40%-60%, stirs, and build heap fermentation, then turning is fermented again.More specifically, described pulverizing refers to, under diameter 5 millimeters of eye equipment, described mixture is ground into the granule being less than or equal to 3 millimeters; The benefit done like this is: allow the active ingredient in crude drug fully ferment.

Described sterilizing is deactivation 20 minutes under 1500 MPa supertension; The object of sterilizing allows all raw materials entering fermenting procedure keep aseptic, thus make the product, bath slurry and/or the dipping goods that prepare be sterile product, allows user/consumer/patient be among clean aseptic environment when use or dipping.

Described heap of building ferments for fermentation is warming up to 75-78 DEG C for 48-112 hour; The object of softening sawdust can be reached.

Described turning is fermented for after fermentation 48-96 hour again, is warming up to 55-60 DEG C; The benefit done like this is, cooling makes fermented product balanced.

The present invention also asks the preparation method protecting described dipping goods, its step and corresponding good effect described above.

The present invention also asks protection package to contain the dipping bath slurry of described dipping goods.Making the dipping bath slurry that finished product packing is good, is the portable degree in order to improve product of the present invention.The bath slurry of finished product packing can allow user/consumer/patient buy voluntarily as required and use.

The present invention also asks to protect described dipping goods preparing the purposes in the dipping articles for use and/or preparation promoting blood circulation and stopping pain medicine for external use with promoting blood circulation and stopping pain effect.Adopt dipping goods of the present invention, can the appropriate application in the place of smouldering pain; Or the technique adopting unguentum, applicator field to commonly use is made containing dipping goods of the present invention at interior unguentum, applicator, for affected part to reach the object of promoting blood circulation and stopping pain.

Dipping goods provided by the present invention and based on the dipping bath slurry of these dipping goods, dipping articles for use and/or promoting blood circulation and stopping pain medicine for external use, its sufficient raw, group and proportioning are simple, material environment friendly, with low cost, and empirical tests, there is the effect of good promoting blood circulation and stopping pain.The preparation method of described dipping goods provided by the invention, step is simple, easy to operate, without the need to special equipment and machine, the effective ingredient of two kinds of key raw material can farthest be discharged by the dipping goods prepared by the method, and the goods of acquisition can reach more significant therapeutic effect.

Detailed description of the invention

Further describe goods of the present invention below in conjunction with specific embodiment, but do not limit the scope of the invention with this.If no special instructions, all commercially available acquisition of following adopted reagent and material, the method adopted is routine operation.

The goods that the embodiment of the present invention provides refer to that loose point gets arbitrary numerical value between 10%-30% part, arbitrary numerical value gained between 90%-70% is got at Masson Pine end mixture is added the water that percentage by weight is 60%-65% institute and fermented and the goods that obtain, and the goods of following examples 1-9 are that the raw mixture of wherein 9 typical proportions ferments and forms.

The preparation of embodiment 1-9,1-9 dipping goods of the present invention

the bath of pine point and bath slurry thereof

Table 1.1-9 goods crude drug formula

Raw material: Song Jian, Masson Pine end

Ratio: the ratio at 1-9 goods pine point and Masson Pine end as shown in Table 1.

Manufacture method: after drying, under diameter 5 millimeters of eye equipment, be ground into the granule being less than or equal to 3 millimeters, be placed in less than 30 DEG C, deactivation 20 minutes under 1500 MPa supertension, add and be cooled to the drinking water of 60 DEG C after boiling, above-mentioned hot water accounts for the percentage by weight of 1-9 dipping goods respectively as shown in Table 1, then stirs 5 minutes in blender, builds heap fermentation, 75-78 DEG C is warming up to through 48-112 hour, turning is fermented again, after 48-96 hour, is warming up to 55-60 DEG C.Products therefrom and dipping goods of the present invention.

By described dipping goods packaging, often bag 15 kilograms is for subsequent use.By above-mentioned dipping stacks in the tub of 2 × 1.5 × 0.7 (m), the heap of the goods of dipping described in tub is high-volume 10 bags, amounts to 150 kilograms, the bath of obtained pine point.

The using method of pine point bath: people is embedded in wherein, stands up after 10 minutes, shower; At normal temperatures, perspire 5 minutes, can promoting blood circulation and stopping pain.

unguentum

Raw material: Song Jian, Masson Pine end

Ratio: the ratio at 1-9 goods pine point and Masson Pine end as shown in Table 1.

Manufacture method: after drying, under diameter 5 millimeters of eye equipment, be ground into the granule being less than or equal to 3 millimeters, be placed in less than 30 DEG C, deactivation 20 minutes under 1500 MPa supertension, add and be cooled to the drinking water of 60 DEG C after boiling, above-mentioned hot water accounts for the percentage by weight of 1-9 dipping goods respectively as shown in Table 1, then stirs 5 minutes in blender, builds heap fermentation, 75-78 DEG C is warming up to through 48-112 hour, turning is fermented again, after 48-96 hour, is warming up to 55-60 DEG C.Products therefrom is prepared into the unguentum with promoting blood circulation and stopping pain effect through the unguentum preparation technology of this area routine again.The unguentum preparation technology of described this area routine can refer to the concrete steps recorded in " preparation technology of pain relieving plaster unguentum and quality standard research " literary composition.

The using method of the unguentum described in the present embodiment: get and be applied in affected part in right amount, with promoting blood circulation and stopping pain.

patch

Raw material: Song Jian, Masson Pine end

Ratio: the ratio at 1-9 goods pine point and Masson Pine end as shown in Table 1.

Manufacture method: after drying, under diameter 5 millimeters of eye equipment, be ground into the granule being less than or equal to 3 millimeters, be placed in less than 30 DEG C, deactivation 20 minutes under 1500 MPa supertension, add and be cooled to the drinking water of 60 DEG C after boiling, above-mentioned hot water accounts for the percentage by weight of 1-9 dipping goods respectively as shown in Table 1, then stirs 5 minutes in blender, builds heap fermentation, 75-78 DEG C is warming up to through 48-112 hour, turning is fermented again, after 48-96 hour, is warming up to 55-60 DEG C.Products therefrom is prepared into the patch with promoting blood circulation and stopping pain effect through the patch preparation technology of this area routine again.The patch preparation technology of described this area routine can refer to the concrete steps recorded in " preparation and the transdermal administration of enoxolone ethosome hydrogel patch are studied " literary composition.

The using method of the patch described in the present embodiment: get one or number is puted up agent and is applied to affected part, with promoting blood circulation and stopping pain.

Experimental example, goods of the present invention clinical verification statistics in promoting blood circulation and stopping pain

Clinical observation case 100 example, be divided into 10 groups, 9 groups of 90 patients use the goods of embodiment 1-9 respectively.

Chief complaint: traumatic injury, swelling and pain due to blood stasis; Bones and muscles pain, muscular paralysis, subcutaneous nodule, joint aches; The unknown pain that the cervical spondylosiss such as hyperosteogeny of cervical vertebra, cervical vertebra disfiguration, tetanic, cervical intervertebral disk prominent (taking off) goes out cause; The pain that arthritis, hyperosteogeny, scapulohumeral periarthritis, vasculitis, gout etc. cause; Lumbar spondylosis, the old waist lower limbs such as lumbar intervertebral disc prominent (taking off) goes out, lumbar muscle strain, hyperosteogeny.

According to the using method of the pine point bath goods in above-described embodiment, every day uses 1-2 time, 7 days courses for the treatment of.

Statistical result: after 100 routine clinical patients use goods of the present invention, most of patient obtains obvious therapeutic effect, and main manifestations is: pain reduces, outbreak reduces, or pain disappears completely, and muscle is not ached stiff, effective percentage 98%, cure rate 67%.

Model case is sketched:

Model case one: king XX, man, 46 years old, suffers from gout for a long time, and after using 3 courses for the treatment of of No. 6 goods of the present invention, gout symptom is obviously alleviated even to disappear.

Model case two: Lee XX, female, 52 years old, suffers from scapulohumeral periarthritis, and main manifestations is, produces pain gradually with shoulder, and night is very, increases the weight of gradually, shoulder mobility function limitation and day by day increasing the weight of; After using 4 courses for the treatment of of the present invention's No. 1 goods, above-mentioned symptom is obviously eased, and shoulder pain disappears, and shoulder activity recovers normal.

Model case three: Yan XX, man, 58 years old, flank pain is shown because suffering from prolapse of lumbar intervertebral disc, a series of clinical symptoms such as side lower limb or two numbness of lower limbs, pain, after using 3 courses for the treatment of of No. 2 goods, above-mentioned symptom is obviously eased, until disappear, up to the present continue 7 moonsets and occurred above-mentioned symptom.

Model case four: Zhao XX, female, 21 years old, ankle from sprains, caused pain; Be embedded in by ankle in the present invention's No. 4 goods and carry out dipping, after 1 course for the treatment of, ankle pain disappears completely.

Model case five a: XX, female, 51 years old, suffers from rheumatic arthritis, and main manifestations is, knee joint local presents red, swollen, scorching hot, severe pain; After using 2 courses for the treatment of of No. 5 goods, above-mentioned symptom is obviously eased, and the gonalgia alleviates.

Model case six: Lee XX, man, 62 years old, old lumbago and skelalgia, daily routines are limited; After using 4 courses for the treatment of of the present invention's No. 9 goods, pain disappears, daily routines recover normal.

Model case seven: grandson XX, man, 45 years old, lumbar muscle strain, main manifestations is, waist or lumbosacral region distending pain, aches, recurrent exerbation; After using 5 courses for the treatment of of the present invention's No. 7 goods, above-mentioned symptom is obviously alleviated, and has up to the present continued repeatedly not occur above-mentioned symptom again in 12 months.

Model case eight: old XX, female, 60 years old, perplexs by hyperosteogeny all the year round, main manifestations is, the gonalgia is violent, ankylosis sense, limitation of movement, can only dependance on wheel chair, after using 3 courses for the treatment of of the present invention's No. 8 goods, above-mentioned pain symptom obviously alleviates, and can normally walk.

Model case nine: Xu XX, female, 48 years old, suffers from cervical spondylosis, and main manifestations is, cervical vertebra is normally bending to disappear, and feels local and aches, there will be dizziness, the symptoms such as numbness of hand time serious; After using 1 course for the treatment of of No. 3 goods, cervical vertebra can normally bend, sense of aching obviously alleviates; After continuing to use 2 courses for the treatment of of these goods, above-mentioned symptom disappears completely.

Model case ten: Liu XX, man, 32 years old, prolapse of cervical intervertebral disc, main manifestations is, chronic low back pain also radiates to lower limb, sometimes occurs that vertebra takes up the even amyotrophy of lower limb muscles spasm, limitation of activity; After using 2 courses for the treatment of of No. 1 goods, above-mentioned symptom is obviously eased, until disappear, only occurs a malaise symptoms in up to the present 5 months.

Claims (10)

1. dipping goods, is characterized in that, its active ingredient is for pine point with Masson Pine is last obtains through fermentation for crude drug.

2. dipping goods according to claim 1, is characterized in that, in described crude drug, the weight ratio at pine point and Masson Pine end is: 10-30:90-70.

3. dipping goods according to claim 1 and 2, is characterized in that, water content is 60%-65%.

4. dipping goods according to claim 3, is characterized in that, described fermentation refers to, after crude drug pulverizing, the sterilizing of room temperature superpressure, add water mixing, builds heap fermentation, then turning is fermented again, and institute's amount of water makes the described dipping goods of fermentation gained reach described water content 40%-60%.

5. dipping goods according to claim 4, is characterized in that, described pulverizing refers to, described crude drug are ground into the granule being less than or equal to 3 millimeters;

Described sterilizing is: room temperature, deactivation 20 minutes under 1500 MPa supertension, rear cooling,

Described heap of building ferments for after fermentation 48-112 hour, is warming up to 75-78 DEG C;

Described turning is fermented and is referred to that turning after fermentation is after 48-96 hour, until be warming up to 55-60 DEG C.

6. the dipping goods according to claim 4 or 5, is characterized in that, the described water used that adds water refers to the drinking water being cooled to 60 DEG C after boiling.

7. a preparation method for dipping goods, comprises the steps:

(1) crude drug is prepared: the weight ratio at pine point and Masson Pine end is: 10-30:90-70;

(2) pulverize;

(3) autoclaving, cooling;

(4) add water mixing, and build heap fermentation, turning is fermented again.

8. preparation method according to claim 7, is characterized in that, described pulverizing refers to, under diameter 5 millimeters of eye equipment, described mixture is ground into the granule being less than or equal to 3 millimeters;

Described sterilizing is deactivation 20 minutes under 1500 MPa supertension;

Described heap of building ferments for fermentation is warming up to 75-78 DEG C for 48-112 hour;

Described turning is fermented for after fermentation 48-96 hour again, is warming up to 55-60 DEG C;

Described water refers to the drinking water being cooled to 60 DEG C after boiling.

9. the purposes of the arbitrary described dipping goods of claim 1-6 in preparation promoting blood circulation and stopping pain medicine for external use.

10. a promoting blood circulation and stopping pain medicine for external use, is characterized in that, active ingredient comprises the arbitrary described goods of claim 1-6.